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Michael Melnick, BA, DDS, PhD

Title(s)Professor
Phone+1 213 740 1417
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    Collapse Research 
    Collapse Research Activities and Funding
    CMV-Induced Embryonic Cochlear Pathogenesis
    NIH/NIDCD R21DC010424Dec 4, 2009 - Nov 30, 2013
    Role: Co-Principal Investigator
    IGF-IIR, IMPRINTING, AND PALATE DEVELOPMENT
    NIH/NIDCR R03DE012111Jun 1, 1997 - May 31, 2000
    Role: Principal Investigator
    SYMPOSIUM--CLINICAL EMBRYOLOGY OF CNS ANOMALIES
    NIH/NINDS R13NS026981Apr 1, 1989 - Mar 31, 1990
    Role: Principal Investigator
    ORAL-FACIAL CLEFTS IN CHINA
    NIH/NIDCR R01DE007360May 1, 1986 - Apr 30, 1993
    Role: Principal Investigator
    TRAINING PROGRAM IN CRANIOFACIAL BIOLOGY (CBY)
    NIH/NIDCR T32DE007006Jul 1, 1975 - Jun 30, 1997
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Melnick M, Jaskoll T. CMV-induced embryonic mouse organ of corti dysplasia: Network architecture of dysfunctional lateral inhibition. Birth Defects Res A Clin Mol Teratol. 2015 Jul; 103(7):573-82. PMID: 26178632.
      View in: PubMed
    2. Melnick M, Deluca KA, Jaskoll T. CMV-induced pathology: pathway and gene-gene interaction analysis. Exp Mol Pathol. 2014 Aug; 97(1):154-65. PMID: 24984270.
      View in: PubMed
    3. Melnick M, Deluca KA, Sedghizadeh PP, Jaskoll T. Cytomegalovirus-induced salivary gland pathology: AREG, FGF8, TNF-a, and IL-6 signal dysregulation and neoplasia. Exp Mol Pathol. 2013 Apr; 94(2):386-97. PMID: 23399805.
      View in: PubMed
    4. Melnick M, Sedghizadeh PP, Deluca KA, Jaskoll T. Cytomegalovirus-induced salivary gland pathology: resistance to kinase inhibitors of the upregulated host cell EGFR/ERK pathway is associated with CMV-dependent stromal overexpression of IL-6 and fibronectin. Herpesviridae. 2013 Jan 23; 4(1):1. PMID: 23342981.
      View in: PubMed
    5. Melnick M, Jaskoll T. An in vitro mouse model of congenital cytomegalovirus-induced pathogenesis of the inner ear cochlea. Birth Defects Res A Clin Mol Teratol. 2013 Feb; 97(2):69-78. PMID: 23281115.
      View in: PubMed
    6. Melnick M, Sedghizadeh PP, Allen CM, Jaskoll T. Human cytomegalovirus and mucoepidermoid carcinoma of salivary glands: cell-specific localization of active viral and oncogenic signaling proteins is confirmatory of a causal relationship. Exp Mol Pathol. 2012 Feb; 92(1):118-25. PMID: 22101257.
      View in: PubMed
    7. Melnick M, Abichaker G, Htet K, Sedghizadeh P, Jaskoll T. Small molecule inhibitors of the host cell COX/AREG/EGFR/ERK pathway attenuate cytomegalovirus-induced pathogenesis. Exp Mol Pathol. 2011 Aug; 91(1):400-10. PMID: 21565184.
      View in: PubMed
    8. Jaskoll T, Htet K, Abichaker G, Kaye FJ, Melnick M. CRTC1 expression during normal and abnormal salivary gland development supports a precursor cell origin for mucoepidermoid cancer. Gene Expr Patterns. 2011 Jan-Feb; 11(1-2):57-63. PMID: 20837164.
      View in: PubMed
    9. Jaskoll T, Abichaker G, Htet K, Bringas P, Morita S, Sedghizadeh PP, Melnick M. Cytomegalovirus induces stage-dependent enamel defects and misexpression of amelogenin, enamelin and dentin sialophosphoprotein in developing mouse molars. Cells Tissues Organs. 2010; 192(4):221-39. PMID: 20484882.
      View in: PubMed
    10. Melnick M, Phair RD, Lapidot SA, Jaskoll T. Salivary gland branching morphogenesis: a quantitative systems analysis of the Eda/Edar/NFkappaB paradigm. BMC Dev Biol. 2009 Jun 06; 9:32. PMID: 19500387.
      View in: PubMed
    11. Jaskoll T, Abichaker G, Sedghizadeh PP, Bringas P, Melnick M. Cytomegalovirus induces abnormal chondrogenesis and osteogenesis during embryonic mandibular development. BMC Dev Biol. 2008 Mar 27; 8:33. PMID: 18371224.
      View in: PubMed
    12. Jaskoll T, Abichaker G, Jangaard N, Bringas P, Melnick M. Cytomegalovirus inhibition of embryonic mouse tooth development: a model of the human amelogenesis imperfecta phenocopy. Arch Oral Biol. 2008 May; 53(5):405-15. PMID: 18201685.
      View in: PubMed
    13. Melnick M, Mocarski ES, Abichaker G, Huang J, Jaskoll T. Cytomegalovirus-induced embryopathology: mouse submandibular salivary gland epithelial-mesenchymal ontogeny as a model. BMC Dev Biol. 2006 Sep 07; 6:42. PMID: 16959038.
      View in: PubMed
    14. Melnick M, Petryk A, Abichaker G, Witcher D, Person AD, Jaskoll T. Embryonic salivary gland dysmorphogenesis in Twisted gastrulation deficient mice. Arch Oral Biol. 2006 May; 51(5):433-8. PMID: 16289463; PMCID: PMC1440928.
    15. Jaskoll T, Abichaker G, Witcher D, Sala FG, Bellusci S, Hajihosseini MK, Melnick M. FGF10/FGFR2b signaling plays essential roles during in vivo embryonic submandibular salivary gland morphogenesis. BMC Dev Biol. 2005 Jun 22; 5:11. PMID: 15972105; PMCID: PMC1184065.
    16. Cho J, Melnick M, Solidakis GP, Tsichlis PN. Tpl2 (tumor progression locus 2) phosphorylation at Thr290 is induced by lipopolysaccharide via an Ikappa-B Kinase-beta-dependent pathway and is required for Tpl2 activation by external signals. J Biol Chem. 2005 May 27; 280(21):20442-8. PMID: 15778223.
      View in: PubMed
    17. Neiswanger K, Cooper ME, Liu YE, Hu DN, Melnick M, Weinberg SM, Marazita ML. Bilateral asymmetry in Chinese families with cleft lip with or without cleft palate. Cleft Palate Craniofac J. 2005 Mar; 42(2):192-6. PMID: 15748111.
      View in: PubMed
    18. Melnick M, Witcher D, Bringas P, Carlsson P, Jaskoll T. Meckel's cartilage differentiation is dependent on hedgehog signaling. Cells Tissues Organs. 2005; 179(4):146-57. PMID: 16046861.
      View in: PubMed
    19. Jaskoll T, Witcher D, Toreno L, Bringas P, Moon AM, Melnick M. FGF8 dose-dependent regulation of embryonic submandibular salivary gland morphogenesis. Dev Biol. 2004 Apr 15; 268(2):457-69. PMID: 15063181.
      View in: PubMed
    20. Jaskoll T, Leo T, Witcher D, Ormestad M, Astorga J, Bringas P, Carlsson P, Melnick M. Sonic hedgehog signaling plays an essential role during embryonic salivary gland epithelial branching morphogenesis. Dev Dyn. 2004 Apr; 229(4):722-32. PMID: 15042696.
      View in: PubMed
    21. Jaskoll T, Zhou YM, Trump G, Melnick M. Ectodysplasin receptor-mediated signaling is essential for embryonic submandibular salivary gland development. Anat Rec A Discov Mol Cell Evol Biol. 2003 Apr; 271(2):322-31. PMID: 12629675.
      View in: PubMed
    22. Chen HW, Marinissen MJ, Oh SW, Chen X, Melnick M, Perrimon N, Gutkind JS, Hou SX. CKA, a novel multidomain protein, regulates the JUN N-terminal kinase signal transduction pathway in Drosophila. Mol Cell Biol. 2002 Mar; 22(6):1792-803. PMID: 11865058.
      View in: PubMed
    23. Jaskoll T, Zhou YM, Chai Y, Makarenkova HP, Collinson JM, West JD, Hajihosseini MK, Lee J, Melnick M. Embryonic submandibular gland morphogenesis: stage-specific protein localization of FGFs, BMPs, Pax6 and Pax9 in normal mice and abnormal SMG phenotypes in FgfR2-IIIc(+/Delta), BMP7(-/-) and Pax6(-/-) mice. Cells Tissues Organs. 2002; 170(2-3):83-98. PMID: 11731698.
      View in: PubMed
    24. Melnick M, Chen H, Min Zhou Y, Jaskoll T. The functional genomic response of developing embryonic submandibular glands to NF-kappa B inhibition. BMC Dev Biol. 2001; 1:15. PMID: 11716784.
      View in: PubMed
    25. Melnick M, Chen H, Zhou Y, Jaskoll T. An alternatively spliced Muc10 glycoprotein ligand for putative L-selectin binding during mouse embryonic submandibular gland morphogenesis. Arch Oral Biol. 2001 Aug; 46(8):745-57. PMID: 11389866.
      View in: PubMed
    26. Jaskoll T, Chen H, Min Zhou Y, Wu D, Melnick M. Developmental expression of survivin during embryonic submandibular salivary gland development. BMC Dev Biol. 2001; 1:5. PMID: 11305929.
      View in: PubMed
    27. Melnick M, Chen H, Zhou Y, Jaskoll T. Embryonic mouse submandibular salivary gland morphogenesis and the TNF/TNF-R1 signal transduction pathway. Anat Rec. 2001 03 01; 262(3):318-30. PMID: 11241200.
      View in: PubMed
    28. Melnick M, Chen H, Zhou YM, Jaskoll T. Interleukin-6 signaling and embryonic mouse submandibular salivary gland morphogenesis. Cells Tissues Organs. 2001; 168(4):233-45. PMID: 11275690.
      View in: PubMed
    29. Melnick M, Chen H, Zhou Y, Jaskoll T. Thrombospondin-2 gene expression and protein localization during embryonic mouse palate development. Arch Oral Biol. 2000 Jan; 45(1):19-25. PMID: 10669089.
      View in: PubMed
    30. Melnick M, Jaskoll T. Mouse submandibular gland morphogenesis: a paradigm for embryonic signal processing. Crit Rev Oral Biol Med. 2000; 11(2):199-215. PMID: 12002815.
      View in: PubMed
    31. Jaskoll T, Melnick M. Submandibular gland morphogenesis: stage-specific expression of TGF-alpha/EGF, IGF, TGF-beta, TNF, and IL-6 signal transduction in normal embryonic mice and the phenotypic effects of TGF-beta2, TGF-beta3, and EGF-r null mutations. Anat Rec. 1999 11 01; 256(3):252-68. PMID: 10521784.
      View in: PubMed
    32. Melnick M, Marazita ML. Neural tube defects, methylenetetrahydrofolate reductase mutation, and north/south dietary differences in China. J Craniofac Genet Dev Biol. 1998 Oct-Dec; 18(4):233-5. PMID: 10100053.
      View in: PubMed
    33. Jaskoll T, Chen H, Denny PC, Denny PA, Melnick M. Mouse submandibular gland mucin: embryo-specific mRNA and protein species. Mech Dev. 1998 Jun; 74(1-2):179-83. PMID: 9651522.
      View in: PubMed
    34. Melnick M, Chen H, Buckley S, Warburton D, Jaskoll T. Insulin-like growth factor II receptor, transforming growth factor-beta, and Cdk4 expression and the developmental epigenetics of mouse palate morphogenesis and dysmorphogenesis. Dev Dyn. 1998 Jan; 211(1):11-25. PMID: 9438420.
      View in: PubMed
    35. Melnick M. Cleft lip and palate etiology and its meaning in early 20th century England: Galton/Pearson vs. Bateson; polygenically poor protoplasm vs. Mendelism. J Craniofac Genet Dev Biol. 1997 Apr-Jun; 17(2):65-79. PMID: 9224941.
      View in: PubMed
    36. Perkins LA, Johnson MR, Melnick MB, Perrimon N. The nonreceptor protein tyrosine phosphatase corkscrew functions in multiple receptor tyrosine kinase pathways in Drosophila. Dev Biol. 1996 Nov 25; 180(1):63-81. PMID: 8948575.
      View in: PubMed
    37. Sameshima GT, Banh DS, Smahel Z, Melnick M. Facial growth after primary periosteoplasty versus primary bone grafting in unilateral cleft lip and palate. Cleft Palate Craniofac J. 1996 Jul; 33(4):300-5. PMID: 8827386.
      View in: PubMed
    38. Jaskoll T, Choy HA, Chen H, Melnick M. Developmental expression and CORT-regulation of TGF-beta and EGF receptor mRNA during mouse palatal morphogenesis: correlation between CORT-induced cleft palate and TGF-beta 2 mRNA expression. Teratology. 1996 Jul; 54(1):34-44. PMID: 8916368.
      View in: PubMed
    39. Melnick M, Chen H, Rich KA, Jaskoll T. Developmental expression of insulin-like growth factor II receptor (IGF-IIR) in congenic mouse embryonic lungs: correlation between IGF-IIR mRNA and protein levels and heterochronic lung development. Mol Reprod Dev. 1996 Jun; 44(2):159-70. PMID: 9115713.
      View in: PubMed
    40. Jaskoll T, Choy HA, Melnick M. The glucocorticoid-glucocorticoid receptor signal transduction pathway, transforming growth factor-beta, and embryonic mouse lung development in vivo. Pediatr Res. 1996 May; 39(5):749-59. PMID: 8726224.
      View in: PubMed
    41. Melnick M, Choy HA, Jaskoll T. Glucocorticoids, tumor necrosis factor-alpha, and epidermal growth factor regulation of pulmonary morphogenesis: a multivariate in vitro analysis of their related actions. Dev Dyn. 1996 Apr; 205(4):365-78. PMID: 8901048.
      View in: PubMed
    42. Hou XS, Melnick MB, Perrimon N. Marelle acts downstream of the Drosophila HOP/JAK kinase and encodes a protein similar to the mammalian STATs. Cell. 1996 Feb 09; 84(3):411-9. PMID: 8608595.
      View in: PubMed
    43. Perrimon N, Lu X, Hou XS, Hsu JC, Melnick MB, Chou TB, Perkins LA. Dissection of the Torso signal transduction pathway in Drosophila. Mol Reprod Dev. 1995 Dec; 42(4):515-22. PMID: 8607984.
      View in: PubMed
    44. Jaskoll T, Choy HA, Chen H, Melnick M. The CORT-GR signal transduction pathway and CORT-induced cleft palate in H-2 congenic mice. J Craniofac Genet Dev Biol. 1995 Apr-Jun; 15(2):57-65. PMID: 7635930.
      View in: PubMed
    45. Jaskoll T, Choy HA, Melnick M. Glucocorticoids, TGF-beta, and embryonic mouse salivary gland morphogenesis. J Craniofac Genet Dev Biol. 1994 Oct-Dec; 14(4):217-30. PMID: 7883868.
      View in: PubMed
    46. Jaskoll T, Boyer PD, Melnick M. Tumor necrosis factor-alpha and embryonic mouse lung morphogenesis. Dev Dyn. 1994 Oct; 201(2):137-50. PMID: 7873786.
      View in: PubMed
    47. Shankar KR, Chuong CM, Jaskoll T, Melnick M. Effect of in ovo retinoic acid exposure on forebrain neural crest: in vitro analysis reveals up-regulation of N-CAM and loss of mesenchymal phenotype. Dev Dyn. 1994 Jun; 200(2):89-102. PMID: 7522652.
      View in: PubMed
    48. Lu X, Melnick MB, Hsu JC, Perrimon N. Genetic and molecular analyses of mutations involved in Drosophila raf signal transduction. EMBO J. 1994 Jun 01; 13(11):2592-9. PMID: 8013459.
      View in: PubMed
    49. Sameshima GT, Melnick M. Finite element-based cephalometric analysis. Angle Orthod. 1994; 64(5):343-50. PMID: 7802328.
      View in: PubMed
    50. Jaskoll T, Luttge WG, Sakai DD, Nichols NR, Melnick M. H-2 gene complex and corticosteroid responsiveness: evidence that the corticosteroid hormone signal transduction pathway in the adult mouse lung is not associated with haplotype-specific responses to corticosteroids. Steroids. 1993 Sep; 58(9):400-6. PMID: 8236324.
      View in: PubMed
    51. Melnick MB, Perkins LA, Lee M, Ambrosio L, Perrimon N. Developmental and molecular characterization of mutations in the Drosophila-raf serine/threonine protein kinase. Development. 1993 May; 118(1):127-38. PMID: 8375330.
      View in: PubMed
    52. Melnick M, Jaskoll T. H-2 haplotype and heterochronic orofacial morphogenesis in congenic mice: consideration as a possible explanation for differential susceptibility to teratogenesis. J Craniofac Genet Dev Biol. 1992 Oct-Dec; 12(4):190-5. PMID: 1494024.
      View in: PubMed
    53. Melnick M. Cleft lip (+/- cleft palate) etiology: a search for solutions. Am J Med Genet. 1992 Jan 01; 42(1):10-4. PMID: 1308346.
      View in: PubMed
    54. Jaskoll T, Greenberg G, Melnick M. Neural tube and neural crest: a new view with time-lapse high-definition photomicroscopy. Am J Med Genet. 1991 Dec 01; 41(3):333-45. PMID: 1789290.
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    55. Jaskoll T, Hu CC, Melnick M. Mouse major histocompatibility complex and lung development: haplotype variation, H-2 immunolocalization, and progressive maturation. Am J Med Genet. 1991 Jun 15; 39(4):422-36. PMID: 1877621.
      View in: PubMed
    56. Silberstein R, Melnick M, Greenberg G, Minkin C. Bone remodeling in W/Wv mast cell deficient mice. Bone. 1991; 12(4):227-36. PMID: 1793671.
      View in: PubMed
    57. Hu CC, Jaskoll TF, Minkin C, Melnick M. Mouse major histocompatibility complex (H-2) and fetal lung development: implications for human pulmonary maturation. Am J Med Genet. 1990 Jan; 35(1):126-31. PMID: 2301462.
      View in: PubMed
    58. Rosenstein R, Greenberg G, Melnick M, Minkin C. Mast cells in bone remodeling: using a genetically defined mouse model as a clue to human disease. Birth Defects Orig Artic Ser. 1989; 25(4):15-25. PMID: 2627573.
      View in: PubMed
    59. Melnick M. In honor of David Bixler. Acknowledgment and comments. Birth Defects Orig Artic Ser. 1989; 25(4):1-5. PMID: 2697380.
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    60. Yorita GJ, Melnick M. Cleft lip and handedness: a study of laterality. Am J Med Genet. 1988 Oct; 31(2):273-80. PMID: 3232695.
      View in: PubMed
    61. Melnick M, Marazita ML, Hu DN. Genetic analysis of cleft lip with or without cleft palate in Chinese kindreds. Am J Med Genet Suppl. 1986; 2:183-90. PMID: 3146289.
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