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Michael Melnick, BA, DDS, PhD

Title(s)Professor
AddressDEN 4266
University Park Campus
Los Angeles CA 90089-0641
Phone+1 213 740 1417
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    Collapse Research 
    Collapse Research Activities and Funding
    CMV-Induced Embryonic Cochlear Pathogenesis
    NIH/NIDCD R21DC010424Dec 4, 2009 - Nov 30, 2013
    Role: Co-Principal Investigator
    IGF-IIR, IMPRINTING, AND PALATE DEVELOPMENT
    NIH/NIDCR R03DE012111Jun 1, 1997 - May 31, 2000
    Role: Principal Investigator
    SYMPOSIUM--CLINICAL EMBRYOLOGY OF CNS ANOMALIES
    NIH/NINDS R13NS026981Apr 1, 1989 - Mar 31, 1990
    Role: Principal Investigator
    ORAL-FACIAL CLEFTS IN CHINA
    NIH/NIDCR R01DE007360May 1, 1986 - Apr 30, 1993
    Role: Principal Investigator
    TRAINING PROGRAM IN CRANIOFACIAL BIOLOGY (CBY)
    NIH/NIDCR T32DE007006Jul 1, 1975 - Jun 30, 1997
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. CMV-induced embryonic mouse organ of corti dysplasia: Network architecture of dysfunctional lateral inhibition. Birth Defects Res A Clin Mol Teratol. 2015 Jul; 103(7):573-82. Melnick M, Jaskoll T. PMID: 26178632.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. CMV-induced pathology: pathway and gene-gene interaction analysis. Exp Mol Pathol. 2014 Aug; 97(1):154-65. Melnick M, Deluca KA, Jaskoll T. PMID: 24984270.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    3. Cytomegalovirus-induced salivary gland pathology: AREG, FGF8, TNF-a, and IL-6 signal dysregulation and neoplasia. Exp Mol Pathol. 2013 Apr; 94(2):386-97. Melnick M, Deluca KA, Sedghizadeh PP, Jaskoll T. PMID: 23399805.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    4. Cytomegalovirus-induced salivary gland pathology: resistance to kinase inhibitors of the upregulated host cell EGFR/ERK pathway is associated with CMV-dependent stromal overexpression of IL-6 and fibronectin. Herpesviridae. 2013 Jan 23; 4(1):1. Melnick M, Sedghizadeh PP, Deluca KA, Jaskoll T. PMID: 23342981.
      View in: PubMed   Mentions:
    5. An in vitro mouse model of congenital cytomegalovirus-induced pathogenesis of the inner ear cochlea. Birth Defects Res A Clin Mol Teratol. 2013 Feb; 97(2):69-78. Melnick M, Jaskoll T. PMID: 23281115.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    6. Human cytomegalovirus and mucoepidermoid carcinoma of salivary glands: cell-specific localization of active viral and oncogenic signaling proteins is confirmatory of a causal relationship. Exp Mol Pathol. 2012 Feb; 92(1):118-25. Melnick M, Sedghizadeh PP, Allen CM, Jaskoll T. PMID: 22101257.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    7. Small molecule inhibitors of the host cell COX/AREG/EGFR/ERK pathway attenuate cytomegalovirus-induced pathogenesis. Exp Mol Pathol. 2011 Aug; 91(1):400-10. Melnick M, Abichaker G, Htet K, Sedghizadeh P, Jaskoll T. PMID: 21565184.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    8. CRTC1 expression during normal and abnormal salivary gland development supports a precursor cell origin for mucoepidermoid cancer. Gene Expr Patterns. 2011 Jan-Feb; 11(1-2):57-63. Jaskoll T, Htet K, Abichaker G, Kaye FJ, Melnick M. PMID: 20837164.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    9. Cytomegalovirus induces stage-dependent enamel defects and misexpression of amelogenin, enamelin and dentin sialophosphoprotein in developing mouse molars. Cells Tissues Organs. 2010; 192(4):221-39. Jaskoll T, Abichaker G, Htet K, Bringas P, Morita S, Sedghizadeh PP, Melnick M. PMID: 20484882.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    10. Salivary gland branching morphogenesis: a quantitative systems analysis of the Eda/Edar/NFkappaB paradigm. BMC Dev Biol. 2009 Jun 06; 9:32. Melnick M, Phair RD, Lapidot SA, Jaskoll T. PMID: 19500387.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    11. Cytomegalovirus induces abnormal chondrogenesis and osteogenesis during embryonic mandibular development. BMC Dev Biol. 2008 Mar 27; 8:33. Jaskoll T, Abichaker G, Sedghizadeh PP, Bringas P, Melnick M. PMID: 18371224.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    12. Cytomegalovirus inhibition of embryonic mouse tooth development: a model of the human amelogenesis imperfecta phenocopy. Arch Oral Biol. 2008 May; 53(5):405-15. Jaskoll T, Abichaker G, Jangaard N, Bringas P, Melnick M. PMID: 18201685.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    13. Cytomegalovirus-induced embryopathology: mouse submandibular salivary gland epithelial-mesenchymal ontogeny as a model. BMC Dev Biol. 2006 Sep 07; 6:42. Melnick M, Mocarski ES, Abichaker G, Huang J, Jaskoll T. PMID: 16959038.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    14. Embryonic salivary gland dysmorphogenesis in Twisted gastrulation deficient mice. Arch Oral Biol. 2006 May; 51(5):433-8. Melnick M, Petryk A, Abichaker G, Witcher D, Person AD, Jaskoll T. PMID: 16289463.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    15. FGF10/FGFR2b signaling plays essential roles during in vivo embryonic submandibular salivary gland morphogenesis. BMC Dev Biol. 2005 Jun 22; 5:11. Jaskoll T, Abichaker G, Witcher D, Sala FG, Bellusci S, Hajihosseini MK, Melnick M. PMID: 15972105.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    16. Tpl2 (tumor progression locus 2) phosphorylation at Thr290 is induced by lipopolysaccharide via an Ikappa-B Kinase-beta-dependent pathway and is required for Tpl2 activation by external signals. J Biol Chem. 2005 May 27; 280(21):20442-8. Cho J, Melnick M, Solidakis GP, Tsichlis PN. PMID: 15778223.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    17. Bilateral asymmetry in Chinese families with cleft lip with or without cleft palate. Cleft Palate Craniofac J. 2005 Mar; 42(2):192-6. Neiswanger K, Cooper ME, Liu YE, Hu DN, Melnick M, Weinberg SM, Marazita ML. PMID: 15748111.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    18. Meckel's cartilage differentiation is dependent on hedgehog signaling. Cells Tissues Organs. 2005; 179(4):146-57. Melnick M, Witcher D, Bringas P, Carlsson P, Jaskoll T. PMID: 16046861.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    19. FGF8 dose-dependent regulation of embryonic submandibular salivary gland morphogenesis. Dev Biol. 2004 Apr 15; 268(2):457-69. Jaskoll T, Witcher D, Toreno L, Bringas P, Moon AM, Melnick M. PMID: 15063181.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    20. Sonic hedgehog signaling plays an essential role during embryonic salivary gland epithelial branching morphogenesis. Dev Dyn. 2004 Apr; 229(4):722-32. Jaskoll T, Leo T, Witcher D, Ormestad M, Astorga J, Bringas P, Carlsson P, Melnick M. PMID: 15042696.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    21. Ectodysplasin receptor-mediated signaling is essential for embryonic submandibular salivary gland development. Anat Rec A Discov Mol Cell Evol Biol. 2003 Apr; 271(2):322-31. Jaskoll T, Zhou YM, Trump G, Melnick M. PMID: 12629675.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    22. CKA, a novel multidomain protein, regulates the JUN N-terminal kinase signal transduction pathway in Drosophila. Mol Cell Biol. 2002 Mar; 22(6):1792-803. Chen HW, Marinissen MJ, Oh SW, Chen X, Melnick M, Perrimon N, Gutkind JS, Hou SX. PMID: 11865058.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    23. Embryonic submandibular gland morphogenesis: stage-specific protein localization of FGFs, BMPs, Pax6 and Pax9 in normal mice and abnormal SMG phenotypes in FgfR2-IIIc(+/Delta), BMP7(-/-) and Pax6(-/-) mice. Cells Tissues Organs. 2002; 170(2-3):83-98. Jaskoll T, Zhou YM, Chai Y, Makarenkova HP, Collinson JM, West JD, Hajihosseini MK, Lee J, Melnick M. PMID: 11731698.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
    24. The functional genomic response of developing embryonic submandibular glands to NF-kappa B inhibition. BMC Dev Biol. 2001; 1:15. Melnick M, Chen H, Min Zhou Y, Jaskoll T. PMID: 11716784.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    25. An alternatively spliced Muc10 glycoprotein ligand for putative L-selectin binding during mouse embryonic submandibular gland morphogenesis. Arch Oral Biol. 2001 Aug; 46(8):745-57. Melnick M, Chen H, Zhou Y, Jaskoll T. PMID: 11389866.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    26. Developmental expression of survivin during embryonic submandibular salivary gland development. BMC Dev Biol. 2001; 1:5. Jaskoll T, Chen H, Min Zhou Y, Wu D, Melnick M. PMID: 11305929.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    27. Embryonic mouse submandibular salivary gland morphogenesis and the TNF/TNF-R1 signal transduction pathway. Anat Rec. 2001 03 01; 262(3):318-30. Melnick M, Chen H, Zhou Y, Jaskoll T. PMID: 11241200.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    28. Interleukin-6 signaling and embryonic mouse submandibular salivary gland morphogenesis. Cells Tissues Organs. 2001; 168(4):233-45. Melnick M, Chen H, Zhou YM, Jaskoll T. PMID: 11275690.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    29. Mouse submandibular gland morphogenesis: a paradigm for embryonic signal processing. Crit Rev Oral Biol Med. 2000; 11(2):199-215. Melnick M, Jaskoll T. PMID: 12002815.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    30. Thrombospondin-2 gene expression and protein localization during embryonic mouse palate development. Arch Oral Biol. 2000 Jan; 45(1):19-25. Melnick M, Chen H, Zhou Y, Jaskoll T. PMID: 10669089.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    31. Submandibular gland morphogenesis: stage-specific expression of TGF-alpha/EGF, IGF, TGF-beta, TNF, and IL-6 signal transduction in normal embryonic mice and the phenotypic effects of TGF-beta2, TGF-beta3, and EGF-r null mutations. Anat Rec. 1999 11 01; 256(3):252-68. Jaskoll T, Melnick M. PMID: 10521784.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    32. Neural tube defects, methylenetetrahydrofolate reductase mutation, and north/south dietary differences in China. J Craniofac Genet Dev Biol. 1998 Oct-Dec; 18(4):233-5. Melnick M, Marazita ML. PMID: 10100053.
      View in: PubMed   Mentions: 2     Fields:    
    33. Mouse submandibular gland mucin: embryo-specific mRNA and protein species. Mech Dev. 1998 Jun; 74(1-2):179-83. Jaskoll T, Chen H, Denny PC, Denny PA, Melnick M. PMID: 9651522.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    34. Insulin-like growth factor II receptor, transforming growth factor-beta, and Cdk4 expression and the developmental epigenetics of mouse palate morphogenesis and dysmorphogenesis. Dev Dyn. 1998 Jan; 211(1):11-25. Melnick M, Chen H, Buckley S, Warburton D, Jaskoll T. PMID: 9438420.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    35. Cleft lip and palate etiology and its meaning in early 20th century England: Galton/Pearson vs. Bateson; polygenically poor protoplasm vs. Mendelism. J Craniofac Genet Dev Biol. 1997 Apr-Jun; 17(2):65-79. Melnick M. PMID: 9224941.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    36. The nonreceptor protein tyrosine phosphatase corkscrew functions in multiple receptor tyrosine kinase pathways in Drosophila. Dev Biol. 1996 Nov 25; 180(1):63-81. Perkins LA, Johnson MR, Melnick MB, Perrimon N. PMID: 8948575.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    37. Developmental expression and CORT-regulation of TGF-beta and EGF receptor mRNA during mouse palatal morphogenesis: correlation between CORT-induced cleft palate and TGF-beta 2 mRNA expression. Teratology. 1996 Jul; 54(1):34-44. Jaskoll T, Choy HA, Chen H, Melnick M. PMID: 8916368.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    38. Facial growth after primary periosteoplasty versus primary bone grafting in unilateral cleft lip and palate. Cleft Palate Craniofac J. 1996 Jul; 33(4):300-5. Sameshima GT, Banh DS, Smahel Z, Melnick M. PMID: 8827386.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    39. Developmental expression of insulin-like growth factor II receptor (IGF-IIR) in congenic mouse embryonic lungs: correlation between IGF-IIR mRNA and protein levels and heterochronic lung development. Mol Reprod Dev. 1996 Jun; 44(2):159-70. Melnick M, Chen H, Rich KA, Jaskoll T. PMID: 9115713.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    40. The glucocorticoid-glucocorticoid receptor signal transduction pathway, transforming growth factor-beta, and embryonic mouse lung development in vivo. Pediatr Res. 1996 May; 39(5):749-59. Jaskoll T, Choy HA, Melnick M. PMID: 8726224.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    41. Glucocorticoids, tumor necrosis factor-alpha, and epidermal growth factor regulation of pulmonary morphogenesis: a multivariate in vitro analysis of their related actions. Dev Dyn. 1996 Apr; 205(4):365-78. Melnick M, Choy HA, Jaskoll T. PMID: 8901048.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    42. Marelle acts downstream of the Drosophila HOP/JAK kinase and encodes a protein similar to the mammalian STATs. Cell. 1996 Feb 09; 84(3):411-9. Hou XS, Melnick MB, Perrimon N. PMID: 8608595.
      View in: PubMed   Mentions: 106     Fields:    Translation:AnimalsCells
    43. Dissection of the Torso signal transduction pathway in Drosophila. Mol Reprod Dev. 1995 Dec; 42(4):515-22. Perrimon N, Lu X, Hou XS, Hsu JC, Melnick MB, Chou TB, Perkins LA. PMID: 8607984.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    44. The CORT-GR signal transduction pathway and CORT-induced cleft palate in H-2 congenic mice. J Craniofac Genet Dev Biol. 1995 Apr-Jun; 15(2):57-65. Jaskoll T, Choy HA, Chen H, Melnick M. PMID: 7635930.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    45. Tumor necrosis factor-alpha and embryonic mouse lung morphogenesis. Dev Dyn. 1994 Oct; 201(2):137-50. Jaskoll T, Boyer PD, Melnick M. PMID: 7873786.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    46. Glucocorticoids, TGF-beta, and embryonic mouse salivary gland morphogenesis. J Craniofac Genet Dev Biol. 1994 Oct-Dec; 14(4):217-30. Jaskoll T, Choy HA, Melnick M. PMID: 7883868.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    47. Effect of in ovo retinoic acid exposure on forebrain neural crest: in vitro analysis reveals up-regulation of N-CAM and loss of mesenchymal phenotype. Dev Dyn. 1994 Jun; 200(2):89-102. Shankar KR, Chuong CM, Jaskoll T, Melnick M. PMID: 7522652.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    48. Genetic and molecular analyses of mutations involved in Drosophila raf signal transduction. EMBO J. 1994 Jun 01; 13(11):2592-9. Lu X, Melnick MB, Hsu JC, Perrimon N. PMID: 8013459.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    49. Finite element-based cephalometric analysis. Angle Orthod. 1994; 64(5):343-50. Sameshima GT, Melnick M. PMID: 7802328.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    50. H-2 gene complex and corticosteroid responsiveness: evidence that the corticosteroid hormone signal transduction pathway in the adult mouse lung is not associated with haplotype-specific responses to corticosteroids. Steroids. 1993 Sep; 58(9):400-6. Jaskoll T, Luttge WG, Sakai DD, Nichols NR, Melnick M. PMID: 8236324.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    51. Developmental and molecular characterization of mutations in the Drosophila-raf serine/threonine protein kinase. Development. 1993 May; 118(1):127-38. Melnick MB, Perkins LA, Lee M, Ambrosio L, Perrimon N. PMID: 8375330.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    52. H-2 haplotype and heterochronic orofacial morphogenesis in congenic mice: consideration as a possible explanation for differential susceptibility to teratogenesis. J Craniofac Genet Dev Biol. 1992 Oct-Dec; 12(4):190-5. Melnick M, Jaskoll T. PMID: 1494024.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    53. Cleft lip (+/- cleft palate) etiology: a search for solutions. Am J Med Genet. 1992 Jan 01; 42(1):10-4. Melnick M. PMID: 1308346.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    54. Neural tube and neural crest: a new view with time-lapse high-definition photomicroscopy. Am J Med Genet. 1991 Dec 01; 41(3):333-45. Jaskoll T, Greenberg G, Melnick M. PMID: 1789290.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    55. Mouse major histocompatibility complex and lung development: haplotype variation, H-2 immunolocalization, and progressive maturation. Am J Med Genet. 1991 Jun 15; 39(4):422-36. Jaskoll T, Hu CC, Melnick M. PMID: 1877621.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    56. Bone remodeling in W/Wv mast cell deficient mice. Bone. 1991; 12(4):227-36. Silberstein R, Melnick M, Greenberg G, Minkin C. PMID: 1793671.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    57. Mouse major histocompatibility complex (H-2) and fetal lung development: implications for human pulmonary maturation. Am J Med Genet. 1990 Jan; 35(1):126-31. Hu CC, Jaskoll TF, Minkin C, Melnick M. PMID: 2301462.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    58. In honor of David Bixler. Acknowledgment and comments. Birth Defects Orig Artic Ser. 1989; 25(4):1-5. Melnick M. PMID: 2697380.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    59. Mast cells in bone remodeling: using a genetically defined mouse model as a clue to human disease. Birth Defects Orig Artic Ser. 1989; 25(4):15-25. Rosenstein R, Greenberg G, Melnick M, Minkin C. PMID: 2627573.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    60. Cleft lip and handedness: a study of laterality. Am J Med Genet. 1988 Oct; 31(2):273-80. Yorita GJ, Melnick M. PMID: 3232695.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    61. Genetic analysis of cleft lip with or without cleft palate in Chinese kindreds. Am J Med Genet Suppl. 1986; 2:183-90. Melnick M, Marazita ML, Hu DN. PMID: 3146289.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
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