Michael Melnick, BA, DDS, PhD

Title(s)Professor
AddressDEN 4266
University Park Campus
Los Angeles CA 90089-0641
Phone+1 213 740 1417
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    Collapse Research 
    Collapse Research Activities and Funding
    CMV-Induced Embryonic Cochlear Pathogenesis
    NIH R21DC010424Dec 4, 2009 - Nov 30, 2013
    Role: Co-Principal Investigator
    IGF-IIR, IMPRINTING, AND PALATE DEVELOPMENT
    NIH R03DE012111Jun 1, 1997 - May 31, 2000
    Role: Principal Investigator
    SYMPOSIUM--CLINICAL EMBRYOLOGY OF CNS ANOMALIES
    NIH R13NS026981Apr 1, 1989 - Mar 31, 1990
    Role: Principal Investigator
    ORAL-FACIAL CLEFTS IN CHINA
    NIH R01DE007360May 1, 1986 - Apr 30, 1993
    Role: Principal Investigator
    TRAINING PROGRAM IN CRANIOFACIAL BIOLOGY (CBY)
    NIH T32DE007006Jul 1, 1975 - Jun 30, 1997
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. CMV-induced embryonic mouse organ of corti dysplasia: Network architecture of dysfunctional lateral inhibition. Birth Defects Res A Clin Mol Teratol. 2015 Jul; 103(7):573-82. Melnick M, Jaskoll T. PMID: 26178632.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. CMV-induced pathology: pathway and gene-gene interaction analysis. Exp Mol Pathol. 2014 Aug; 97(1):154-65. Melnick M, Deluca KA, Jaskoll T. PMID: 24984270.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    3. Cytomegalovirus-induced salivary gland pathology: AREG, FGF8, TNF-a, and IL-6 signal dysregulation and neoplasia. Exp Mol Pathol. 2013 Apr; 94(2):386-97. Melnick M, Deluca KA, Sedghizadeh PP, Jaskoll T. PMID: 23399805.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    4. Cytomegalovirus-induced salivary gland pathology: resistance to kinase inhibitors of the upregulated host cell EGFR/ERK pathway is associated with CMV-dependent stromal overexpression of IL-6 and fibronectin. Herpesviridae. 2013 Jan 23; 4(1):1. Melnick M, Sedghizadeh PP, Deluca KA, Jaskoll T. PMID: 23342981.
      View in: PubMed   Mentions:
    5. An in vitro mouse model of congenital cytomegalovirus-induced pathogenesis of the inner ear cochlea. Birth Defects Res A Clin Mol Teratol. 2013 Feb; 97(2):69-78. Melnick M, Jaskoll T. PMID: 23281115.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    6. Human cytomegalovirus and mucoepidermoid carcinoma of salivary glands: cell-specific localization of active viral and oncogenic signaling proteins is confirmatory of a causal relationship. Exp Mol Pathol. 2012 Feb; 92(1):118-25. Melnick M, Sedghizadeh PP, Allen CM, Jaskoll T. PMID: 22101257.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    7. Small molecule inhibitors of the host cell COX/AREG/EGFR/ERK pathway attenuate cytomegalovirus-induced pathogenesis. Exp Mol Pathol. 2011 Aug; 91(1):400-10. Melnick M, Abichaker G, Htet K, Sedghizadeh P, Jaskoll T. PMID: 21565184.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    8. CRTC1 expression during normal and abnormal salivary gland development supports a precursor cell origin for mucoepidermoid cancer. Gene Expr Patterns. 2011 Jan-Feb; 11(1-2):57-63. Jaskoll T, Htet K, Abichaker G, Kaye FJ, Melnick M. PMID: 20837164.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    9. Dynamic switch of negative feedback regulation in Drosophila Akt-TOR signaling. PLoS Genet. 2010 Jun 17; 6(6):e1000990. Kockel L, Kerr KS, Melnick M, Brückner K, Hebrok M, Perrimon N. PMID: 20585550.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    10. Cytomegalovirus induces stage-dependent enamel defects and misexpression of amelogenin, enamelin and dentin sialophosphoprotein in developing mouse molars. Cells Tissues Organs. 2010; 192(4):221-39. Jaskoll T, Abichaker G, Htet K, Bringas P, Morita S, Sedghizadeh PP, Melnick M. PMID: 20484882.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    11. Salivary gland branching morphogenesis: a quantitative systems analysis of the Eda/Edar/NFkappaB paradigm. BMC Dev Biol. 2009 Jun 06; 9:32. Melnick M, Phair RD, Lapidot SA, Jaskoll T. PMID: 19500387.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    12. Cytomegalovirus induces abnormal chondrogenesis and osteogenesis during embryonic mandibular development. BMC Dev Biol. 2008 Mar 27; 8:33. Jaskoll T, Abichaker G, Sedghizadeh PP, Bringas P, Melnick M. PMID: 18371224.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    13. Cytomegalovirus inhibition of embryonic mouse tooth development: a model of the human amelogenesis imperfecta phenocopy. Arch Oral Biol. 2008 May; 53(5):405-15. Jaskoll T, Abichaker G, Jangaard N, Bringas P, Melnick M. PMID: 18201685.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    14. Cytomegalovirus-induced embryopathology: mouse submandibular salivary gland epithelial-mesenchymal ontogeny as a model. BMC Dev Biol. 2006 Sep 07; 6:42. Melnick M, Mocarski ES, Abichaker G, Huang J, Jaskoll T. PMID: 16959038.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    15. Embryonic salivary gland dysmorphogenesis in Twisted gastrulation deficient mice. Arch Oral Biol. 2006 May; 51(5):433-8. Melnick M, Petryk A, Abichaker G, Witcher D, Person AD, Jaskoll T. PMID: 16289463.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    16. FGF10/FGFR2b signaling plays essential roles during in vivo embryonic submandibular salivary gland morphogenesis. BMC Dev Biol. 2005 Jun 22; 5:11. Jaskoll T, Abichaker G, Witcher D, Sala FG, Bellusci S, Hajihosseini MK, Melnick M. PMID: 15972105.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    17. Tpl2 (tumor progression locus 2) phosphorylation at Thr290 is induced by lipopolysaccharide via an Ikappa-B Kinase-beta-dependent pathway and is required for Tpl2 activation by external signals. J Biol Chem. 2005 May 27; 280(21):20442-8. Cho J, Melnick M, Solidakis GP, Tsichlis PN. PMID: 15778223.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    18. Meckel's cartilage differentiation is dependent on hedgehog signaling. Cells Tissues Organs. 2005; 179(4):146-57. Melnick M, Witcher D, Bringas P, Carlsson P, Jaskoll T. PMID: 16046861.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    19. FGF8 dose-dependent regulation of embryonic submandibular salivary gland morphogenesis. Dev Biol. 2004 Apr 15; 268(2):457-69. Jaskoll T, Witcher D, Toreno L, Bringas P, Moon AM, Melnick M. PMID: 15063181.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    20. Ectodysplasin receptor-mediated signaling is essential for embryonic submandibular salivary gland development. Anat Rec A Discov Mol Cell Evol Biol. 2003 Apr; 271(2):322-31. Jaskoll T, Zhou YM, Trump G, Melnick M. PMID: 12629675.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    21. CKA, a novel multidomain protein, regulates the JUN N-terminal kinase signal transduction pathway in Drosophila. Mol Cell Biol. 2002 Mar; 22(6):1792-803. Chen HW, Marinissen MJ, Oh SW, Chen X, Melnick M, Perrimon N, Gutkind JS, Hou SX. PMID: 11865058.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    22. Embryonic submandibular gland morphogenesis: stage-specific protein localization of FGFs, BMPs, Pax6 and Pax9 in normal mice and abnormal SMG phenotypes in FgfR2-IIIc(+/Delta), BMP7(-/-) and Pax6(-/-) mice. Cells Tissues Organs. 2002; 170(2-3):83-98. Jaskoll T, Zhou YM, Chai Y, Makarenkova HP, Collinson JM, West JD, Hajihosseini MK, Lee J, Melnick M. PMID: 11731698.
      View in: PubMed   Mentions: 42     Fields:    Translation:Animals
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    NIH Funding Acknowledgment: Important - All publications resulting from the utilization of SC CTSI resources are required to credit the SC CTSI grant by including the NIH funding acknowledgment and must comply with the NIH Public Access Policy.

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