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Michael Melnick, BA, DDS, PhD

TitleProfessor
InstitutionUniversity of Southern California
DepartmentBiomedical Engineering
AddressDEN 4266
University Park Campus
Los Angeles CA 90089-0641
Phone+1 213 740 1417
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    Collapse Research 
    Collapse Research Activities and Funding
    CMV-Induced Embryonic Cochlear Pathogenesis
    NIH/NIDCD R21DC010424Dec 4, 2009 - Nov 30, 2013
    Role: Co-Principal Investigator
    IGF-IIR, IMPRINTING, AND PALATE DEVELOPMENT
    NIH/NIDCR R03DE012111Jun 1, 1997 - May 31, 2000
    Role: Principal Investigator
    SYMPOSIUM--CLINICAL EMBRYOLOGY OF CNS ANOMALIES
    NIH/NINDS R13NS026981Apr 1, 1989 - Mar 31, 1990
    Role: Principal Investigator
    ORAL-FACIAL CLEFTS IN CHINA
    NIH/NIDCR R01DE007360May 1, 1986 - Apr 30, 1993
    Role: Principal Investigator
    TRAINING PROGRAM IN CRANIOFACIAL BIOLOGY (CBY)
    NIH/NIDCR T32DE007006Jul 1, 1975 - Jun 30, 1997
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Melnick M, Jaskoll T. CMV-induced embryonic mouse organ of corti dysplasia: Network architecture of dysfunctional lateral inhibition. Birth Defects Res A Clin Mol Teratol. 2015 Jul; 103(7):573-82. PMID: 26178632; PMCID: PMC4509978.
    2. Melnick M, Deluca KA, Jaskoll T. CMV-induced pathology: pathway and gene-gene interaction analysis. Exp Mol Pathol. 2014 Aug; 97(1):154-65. PMID: 24984270.
      View in: PubMed
    3. Melnick M, Deluca KA, Sedghizadeh PP, Jaskoll T. Cytomegalovirus-induced salivary gland pathology: AREG, FGF8, TNF-a, and IL-6 signal dysregulation and neoplasia. Exp Mol Pathol. 2013 Apr; 94(2):386-97. PMID: 23399805.
      View in: PubMed
    4. Melnick M, Sedghizadeh PP, Deluca KA, Jaskoll T. Cytomegalovirus-induced salivary gland pathology: resistance to kinase inhibitors of the upregulated host cell EGFR/ERK pathway is associated with CMV-dependent stromal overexpression of IL-6 and fibronectin. Herpesviridae. 2013 Jan 23; 4(1):1. PMID: 23342981; PMCID: PMC3602079.
    5. Melnick M, Jaskoll T. An in vitro mouse model of congenital cytomegalovirus-induced pathogenesis of the inner ear cochlea. Birth Defects Res A Clin Mol Teratol. 2013 Feb; 97(2):69-78. PMID: 23281115; PMCID: PMC4476032.
    6. Melnick M, Sedghizadeh PP, Allen CM, Jaskoll T. Human cytomegalovirus and mucoepidermoid carcinoma of salivary glands: cell-specific localization of active viral and oncogenic signaling proteins is confirmatory of a causal relationship. Exp Mol Pathol. 2012 Feb; 92(1):118-25. PMID: 22101257.
      View in: PubMed
    7. Melnick M, Abichaker G, Htet K, Sedghizadeh P, Jaskoll T. Small molecule inhibitors of the host cell COX/AREG/EGFR/ERK pathway attenuate cytomegalovirus-induced pathogenesis. Exp Mol Pathol. 2011 Aug; 91(1):400-10. PMID: 21565184; PMCID: PMC3139723.
    8. Jaskoll T, Htet K, Abichaker G, Kaye FJ, Melnick M. CRTC1 expression during normal and abnormal salivary gland development supports a precursor cell origin for mucoepidermoid cancer. Gene Expr Patterns. 2011 Jan-Feb; 11(1-2):57-63. PMID: 20837164; PMCID: PMC3033996.
    9. Jaskoll T, Abichaker G, Htet K, Bringas P, Morita S, Sedghizadeh PP, Melnick M. Cytomegalovirus induces stage-dependent enamel defects and misexpression of amelogenin, enamelin and dentin sialophosphoprotein in developing mouse molars. Cells Tissues Organs. 2010; 192(4):221-39. PMID: 20484882.
      View in: PubMed
    10. Melnick M, Phair RD, Lapidot SA, Jaskoll T. Salivary gland branching morphogenesis: a quantitative systems analysis of the Eda/Edar/NFkappaB paradigm. BMC Dev Biol. 2009 Jun 06; 9:32. PMID: 19500387; PMCID: PMC2700095.
    11. Jaskoll T, Abichaker G, Sedghizadeh PP, Bringas P, Melnick M. Cytomegalovirus induces abnormal chondrogenesis and osteogenesis during embryonic mandibular development. BMC Dev Biol. 2008 Mar 27; 8:33. PMID: 18371224; PMCID: PMC2330031.
    12. Jaskoll T, Abichaker G, Jangaard N, Bringas P, Melnick M. Cytomegalovirus inhibition of embryonic mouse tooth development: a model of the human amelogenesis imperfecta phenocopy. Arch Oral Biol. 2008 May; 53(5):405-15. PMID: 18201685; PMCID: PMC2279100.
    13. Melnick M, Mocarski ES, Abichaker G, Huang J, Jaskoll T. Cytomegalovirus-induced embryopathology: mouse submandibular salivary gland epithelial-mesenchymal ontogeny as a model. BMC Dev Biol. 2006 Sep 07; 6:42. PMID: 16959038; PMCID: PMC1601957.
    14. Melnick M, Petryk A, Abichaker G, Witcher D, Person AD, Jaskoll T. Embryonic salivary gland dysmorphogenesis in Twisted gastrulation deficient mice. Arch Oral Biol. 2006 May; 51(5):433-8. PMID: 16289463; PMCID: PMC1440928.
    15. Jaskoll T, Abichaker G, Witcher D, Sala FG, Bellusci S, Hajihosseini MK, Melnick M. FGF10/FGFR2b signaling plays essential roles during in vivo embryonic submandibular salivary gland morphogenesis. BMC Dev Biol. 2005 Jun 22; 5:11. PMID: 15972105; PMCID: PMC1184065.
    16. Cho J, Melnick M, Solidakis GP, Tsichlis PN. Tpl2 (tumor progression locus 2) phosphorylation at Thr290 is induced by lipopolysaccharide via an Ikappa-B Kinase-beta-dependent pathway and is required for Tpl2 activation by external signals. J Biol Chem. 2005 May 27; 280(21):20442-8. PMID: 15778223.
      View in: PubMed
    17. Melnick M, Witcher D, Bringas P, Carlsson P, Jaskoll T. Meckel's cartilage differentiation is dependent on hedgehog signaling. Cells Tissues Organs. 2005; 179(4):146-57. PMID: 16046861.
      View in: PubMed
    18. Jaskoll T, Witcher D, Toreno L, Bringas P, Moon AM, Melnick M. FGF8 dose-dependent regulation of embryonic submandibular salivary gland morphogenesis. Dev Biol. 2004 Apr 15; 268(2):457-69. PMID: 15063181.
      View in: PubMed
    19. Jaskoll T, Zhou YM, Trump G, Melnick M. Ectodysplasin receptor-mediated signaling is essential for embryonic submandibular salivary gland development. Anat Rec A Discov Mol Cell Evol Biol. 2003 Apr; 271(2):322-31. PMID: 12629675.
      View in: PubMed
    20. Jaskoll T, Zhou YM, Chai Y, Makarenkova HP, Collinson JM, West JD, Hajihosseini MK, Lee J, Melnick M. Embryonic submandibular gland morphogenesis: stage-specific protein localization of FGFs, BMPs, Pax6 and Pax9 in normal mice and abnormal SMG phenotypes in FgfR2-IIIc(+/Delta), BMP7(-/-) and Pax6(-/-) mice. Cells Tissues Organs. 2002; 170(2-3):83-98. PMID: 11731698.
      View in: PubMed
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