Ling Shao, MD, PhD

Title(s)Assistant Professor of Medicine
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    Collapse Biography 
    Collapse Education and Training
    University of California, Berkeley, BerkeleyB.A.1998Neuroscience
    The Mount Sinai School of Medicine, New YorkM.D, Ph.D.2007Immunology
    Collapse Awards and Honors
    The Mount Sinai School of Medicine2003The Mount Sinai Graduate School Service Award
    The Jeffrey Modell Foundation2005The Jeffrey Modell Foundation Award
    The Arnold P. Gold Foundation2006The Arnold P. Gold Humanism Honor Society
    The Mount Sinai School of Medicine2006The Mount Sinai Student Council Teamwork Award
    Inflammatory Bowel Disease Working Group2012The Inflammatory Bowel Disease Working Group Fellowship Award
    Division of Gastroenterology and Liver Diseases, USC2015GI Fellows Teaching Award

    Collapse Overview 
    Collapse Overview
    Dr. Shao's major areas of research interest are inflammatory bowel disease, intestinal epithelial cells, inflammation and immunology. His major area of research interest is the role that intestinal epithelial cells play in the pathogenesis of inflammatory bowel disease. Specifically, he studies how genetics, the immune system, and the microbiome may influence epithelial wound healing, but also predisposes patients to developing colon cancer. He also studies the underlying immune mechanisms of why patients develop resistance to certain medications used to treat inflammatory bowel disease.

    Dr. Shao earned his medical degree from The Mount Sinai School of Medicine. He then performed his residency at University of California, San Francisco, and then stayed on to complete a Gastroenterology Fellowship.

    Collapse Research 
    Collapse Research Activities and Funding
    The Role of A20 in Colitis-Associated Cancer
    NIH/NIDDK R03DK118178Apr 1, 2019 - Feb 28, 2021
    Role: Principal Investigator
    The Ubiquitin Editing Enzyme A20 Preserves Intestinal Epithelial Cell Homeostasis
    NIH/NIDDK K08DK100462Sep 3, 2014 - Jul 31, 2019
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Zhang B, Naomi Nakamura B, Perlman A, Alipour O, Abbasi SQ, Sohn P, Gulati A, Moore G, Hwang C, Sheibani S, Zarchy T, Shao L. Identification of functional missense single-nucleotide polymorphisms in TNFAIP3 in a predominantly Hispanic population. J Clin Transl Sci. 2018 12; 2(6):350-355. PMID: 31131138.
      View in: PubMed
    2. Kattah MG, Shao L, Rosli YY, Shimizu H, Whang MI, Advincula R, Achacoso P, Shah S, Duong BH, Onizawa M, Tanbun P, Malynn BA, Ma A. A20 and ABIN-1 synergistically preserve intestinal epithelial cell survival. J Exp Med. 2018 Jul 02; 215(7):1839-1852. PMID: 29930103.
      View in: PubMed
    3. Nakamura BN, Glazier A, Kattah MG, Duong B, Jia Y, Campo D, Shao L. A20 regulates canonical wnt-signaling through an interaction with RIPK4. PLoS One. 2018; 13(5):e0195893. PMID: 29718933.
      View in: PubMed
    4. Zhang B, Martin VK, Motamedi N, Shao L. Isolated Ileocolonic Histoplasmosis in an HIV-Negative Patient. Dig Dis Sci. 2017 Aug; 62(8):2201-2202. PMID: 28547647.
      View in: PubMed
    5. Chirra HD, Shao L, Ciaccio N, Fox CB, Wade JM, Ma A, Desai TA. Planar microdevices for enhanced in vivo retention and oral bioavailability of poorly permeable drugs. Adv Healthc Mater. 2014 Oct; 3(10):1648-54. PMID: 24711341; PMCID: PMC4256094.
    6. Shao L, Oshima S, Duong B, Advincula R, Barrera J, Malynn BA, Ma A. A20 restricts wnt signaling in intestinal epithelial cells and suppresses colon carcinogenesis. PLoS One. 2013; 8(5):e62223. PMID: 23671587; PMCID: PMC3645994.
    7. Perera L, Shao L, Patel A, Evans K, Meresse B, Blumberg R, Geraghty D, Groh V, Spies T, Jabri B, Mayer L. Expression of nonclassical class I molecules by intestinal epithelial cells. Inflamm Bowel Dis. 2007 Mar; 13(3):298-307. PMID: 17238179.
      View in: PubMed
    8. Shao L, Allez M, Park MS, Mayer L. Immunomodulatory roles of the carcinoembryonic antigen family of glycoproteins. Ann N Y Acad Sci. 2006 Aug; 1072:194-209. PMID: 17057200.
      View in: PubMed
    9. Kentsis A, Volpon L, Topisirovic I, Soll CE, Culjkovic B, Shao L, Borden KL. Further evidence that ribavirin interacts with eIF4E. RNA. 2005 Dec; 11(12):1762-6. PMID: 16251386; PMCID: PMC1370864.
    10. Shao L, Kamalu O, Mayer L. Non-classical MHC class I molecules on intestinal epithelial cells: mediators of mucosal crosstalk. Immunol Rev. 2005 Aug; 206:160-76. PMID: 16048548.
      View in: PubMed
    11. Shao L, Jacobs AR, Johnson VV, Mayer L. Activation of CD8+ regulatory T cells by human placental trophoblasts. J Immunol. 2005 Jun 15; 174(12):7539-47. PMID: 15944253.
      View in: PubMed
    12. Brimnes J, Allez M, Dotan I, Shao L, Nakazawa A, Mayer L. Defects in CD8+ regulatory T cells in the lamina propria of patients with inflammatory bowel disease. J Immunol. 2005 May 01; 174(9):5814-22. PMID: 15843585.
      View in: PubMed
    13. Kentsis A, Topisirovic I, Culjkovic B, Shao L, Borden KL. Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap. Proc Natl Acad Sci U S A. 2004 Dec 28; 101(52):18105-10. PMID: 15601771; PMCID: PMC539790.
    14. Allez M, Brimnes J, Shao L, Dotan I, Nakazawa A, Mayer L. Activation of a unique population of CD8(+) T cells by intestinal epithelial cells. Ann N Y Acad Sci. 2004 Dec; 1029:22-35. PMID: 15681740.
      View in: PubMed
    15. Shao L, Mayer L. Treatment of disease through oral tolerance. Discov Med. 2004 Oct; 4(23):338-43. PMID: 20704971.
      View in: PubMed
    16. Mayer L, Shao L. Therapeutic potential of oral tolerance. Nat Rev Immunol. 2004 Jun; 4(6):407-19. PMID: 15173830.
      View in: PubMed
    17. Mayer L, Shao L. The use of oral tolerance in the therapy of chronic inflammatory/autoimmune diseases. J Pediatr Gastroenterol Nutr. 2004 Jun; 39 Suppl 3:S746-7. PMID: 15167372.
      View in: PubMed
    18. Nakazawa A, Dotan I, Brimnes J, Allez M, Shao L, Tsushima F, Azuma M, Mayer L. The expression and function of costimulatory molecules B7H and B7-H1 on colonic epithelial cells. Gastroenterology. 2004 May; 126(5):1347-57. PMID: 15131796.
      View in: PubMed
    19. Sperber K, Shao L. Neurologic consequences of HIV infection in the era of HAART. AIDS Patient Care STDS. 2003 Oct; 17(10):509-18. PMID: 14588091.
      View in: PubMed
    20. Colgan SP, Pitman RS, Nagaishi T, Mizoguchi A, Mizoguchi E, Mayer LF, Shao L, Sartor RB, Subjeck JR, Blumberg RS. Intestinal heat shock protein 110 regulates expression of CD1d on intestinal epithelial cells. J Clin Invest. 2003 Sep; 112(5):745-54. PMID: 12952923; PMCID: PMC182184.
    21. Shao L, Sperber K. Impaired regulation of HLA-DR expression in human immunodeficiency virus-infected monocytes. Clin Diagn Lab Immunol. 2002 Jul; 9(4):739-46. PMID: 12093667; PMCID: PMC120040.
    22. Shao L, Serrano D, Mayer L. The role of epithelial cells in immune regulation in the gut. Semin Immunol. 2001 Jun; 13(3):163-76. PMID: 11394959.
      View in: PubMed