Lindsay A. Renfro, PhD
Biography Texas Woman's University | B.S. | 05/2005 | Mathematics | Rice University | Ph.D. Student | 05/2006 | Statistics | Baylor University | M.S. | 12/2007 | Statistics | Baylor University | Ph.D. | 03/2011 | Statistics |
Texas Woman's University | 2018 | | Hallmark Alumni Award | Mayo Clinic | 2015
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| 2018 | KL2 Mentored Career Development Award | ENAR / International Biometric Society | 2011 | | Distinguished Student Paper Award | Baylor University | 2006
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| 2011 | Dean's Stipend Enhancement Award | National Science Foundation, National Center for Education Statistics | 2010 | | Fellow, National Summer Data Policy Institute | Association for Institutional Research, National Center for Education Statistics | 2008
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| 2010 | AIR/NCES Graduate Fellowship | Association for Institutional Research | 2007 | | Best Paper Award | Kappa Mu Epsilon National Mathematics Honor Society | 2005 | | Best Paper Award | Texas Woman's University | 2005 | | Chancellor's Research Scholar | Texas Woman's University | 2004
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| 2005 | Harlan Miller Award and Memorial Scholarship | Texas Instruments | 2003
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| 2005 | Women in Engineering Award and Scholarship |
Overview Dr. Lindsay Renfro is an Associate Professor of Research at the University of Southern California and the Associate Group Statistician for Children's Oncology Group (COG). COG is the pediatric cooperative group member of the NIH/NCI's National Clinical Trials Network and the world's largest organization dedicated exclusively to pediatric cancer research. Within COG, Dr. Renfro is also a faculty statistician for the Renal Tumors Committee, where she leads the design and analysis of therapeutic and biology-driven clinical trials for Wilms Tumor and related projects in pediatric renal cancer. Her expertise and methodological interests also include novel trial designs (e.g., adaptive, Bayesian, biomarker-driven, and master protocols), evaluation and validation of surrogate endpoints in clinical trials, and construction, validation, and implementation of disease-specific prognostic calculators for clinical use and decision-making. Dr. Renfro also enjoys teaching statistics to non-statisticians, mentoring students, traveling, and enjoying the mountains and beaches of Southern California with her son, Will.
clinical trials, adaptive design, Bayesian adaptive design, biomarker-driven trials, basket trials, umbrella trials, cancer clinical trials, pediatric cancer trials, Wilms tumor, colorectal cancer, colon cancer, surrogate endpoints, surrogate endpoint evaluation, clinical prediction modeling, clinical calculators, patient calculators, calculator construction and validation
Research ORNG Applications Bibliographic
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Point and interval estimation in two-stage adaptive designs with time to event data and biomarker-driven subpopulation selection. Stat Med. 2020 Aug 30; 39(19):2568-2586.
Kimani PK, Todd S, Renfro LA, Glimm E, Khan JN, Kairalla JA, Stallard N. PMID: 32363603.
View in: PubMed Mentions: Fields:
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Reply to D.M. Green. J Clin Oncol. 2020 03 01; 38(7):773-774.
Dix DB, Fernandez CV, Chi YY, Renfro LA, Md JSD. PMID: 31951494.
View in: PubMed Mentions: Fields: Translation: Humans
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Trial Design Challenges and Approaches for Precision Oncology in Rare Tumors: Experiences of the Children's Oncology Group. JCO Precis Oncol. 2019; 3.
Renfro LA, Ji L, Piao J, Onar-Thomas A, Kairalla JA, Alonzo TA. PMID: 32923863.
View in: PubMed Mentions:
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Influence of genetic variation in the vitamin D pathway on plasma 25-hydroxyvitamin D3 levels and survival among patients with metastatic colorectal cancer. Cancer Causes Control. 2019 Jul; 30(7):757-765.
Yuan C, Renfro L, Ambadwar PB, Ou FS, McLeod HL, Innocenti F, Meyerhardt JA, Wolpin BM, Goldberg RM, Grothey A, Fuchs CS, Ng K. PMID: 31104167.
View in: PubMed Mentions: Fields: Translation: HumansCTClinical Trials
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On the need to adjust for multiplicity in confirmatory clinical trials with master protocols. Ann Oncol. 2019 04 01; 30(4):506-509.
Stallard N, Todd S, Parashar D, Kimani PK, Renfro LA. PMID: 30715156.
View in: PubMed Mentions: 1 Fields: Translation: Humans
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Clinicopathological differences and survival outcomes with first-line therapy in patients with left-sided colon cancer and rectal cancer: Pooled analysis of 2879 patients from AGITG (MAX), COIN, FOCUS2, OPUS, CRYSTAL and COIN-B trials in the ARCAD database. Eur J Cancer. 2018 11; 103:205-213.
Salem ME, Yin J, Weinberg BA, Renfro LA, Pederson LD, Maughan TS, Adams RA, Van Cutsem E, Falcone A, Tebbutt NC, Seymour MT, Díaz-Rubio E, Aranda E, Bokemeyer C, Heinemann V, Wasan H, de Gramont A, Grothey A, Shi Q, Sargent DJ, Marshall JL. PMID: 30268921.
View in: PubMed Mentions: 1 Fields: Translation: Humans
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Personalizing Survival Predictions in Advanced Colorectal Cancer: The ARCAD Nomogram Project. J Natl Cancer Inst. 2018 06 01; 110(6):638-648.
Sjoquist KM, Renfro LA, Simes RJ, Tebbutt NC, Clarke S, Seymour MT, Adams R, Maughan TS, Saltz L, Goldberg RM, Schmoll HJ, Van Cutsem E, Douillard JY, Hoff PM, Hecht JR, Tournigand C, Punt CJA, Koopman M, Hurwitz H, Heinemann V, Falcone A, Porschen R, Fuchs C, Diaz-Rubio E, Aranda E, Bokemeyer C, Souglakos I, Kabbinavar FF, Chibaudel B, Meyers JP, Sargent DJ, de Gramont A, Zalcberg JR. PMID: 29267900.
View in: PubMed Mentions: 23 Fields: Translation: HumansCTClinical Trials
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Point estimation following two-stage adaptive threshold enrichment clinical trials. Stat Med. 2018 09 30; 37(22):3179-3196.
Kimani PK, Todd S, Renfro LA, Stallard N. PMID: 29855066.
View in: PubMed Mentions: Fields: Translation: Humans
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Duration of Adjuvant Chemotherapy for Stage III Colon Cancer. N Engl J Med. 2018 Mar 29; 378(13):1177-1188.
Grothey A, Sobrero AF, Shields AF, Yoshino T, Paul J, Taieb J, Souglakos J, Shi Q, Kerr R, Labianca R, Meyerhardt JA, Vernerey D, Yamanaka T, Boukovinas I, Meyers JP, Renfro LA, Niedzwiecki D, Watanabe T, Torri V, Saunders M, Sargent DJ, Andre T, Iveson T. PMID: 29590544.
View in: PubMed Mentions: 102 Fields: Translation: Humans
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A Randomized, Double-Blind, Placebo-Controlled Phase II Study of the Efficacy and Safety of Monotherapy Ontuxizumab (MORAb-004) Plus Best Supportive Care in Patients with Chemorefractory Metastatic Colorectal Cancer. Clin Cancer Res. 2018 01 15; 24(2):316-325.
Grothey A, Strosberg JR, Renfro LA, Hurwitz HI, Marshall JL, Safran H, Guarino MJ, Kim GP, Hecht JR, Weil SC, Heyburn J, Wang W, Schweizer C, O'Shannessy DJ, Diaz LA. PMID: 29084918.
View in: PubMed Mentions: 4 Fields: Translation: HumansCTClinical Trials
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Definitions and statistical properties of master protocols for personalized medicine in oncology. J Biopharm Stat. 2018; 28(2):217-228.
PMID: 28877008.
View in: PubMed Mentions: 5 Fields: Translation: Humans
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Non-V600 BRAF Mutations Define a Clinically Distinct Molecular Subtype of Metastatic Colorectal Cancer. J Clin Oncol. 2017 Aug 10; 35(23):2624-2630.
PMID: 28486044.
View in: PubMed Mentions: 61 Fields: Translation: Humans
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Anorectal Function and Quality of Life in Patients With Early Stage Rectal Cancer Treated With Chemoradiation and Local Excision. Dis Colon Rectum. 2017 May; 60(5):459-468.
PMID: 28383445.
View in: PubMed Mentions: 3 Fields: Translation: HumansCTClinical Trials
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Clinical Calculator for Early Mortality in Metastatic Colorectal Cancer: An Analysis of Patients From 28 Clinical Trials in the Aide et Recherche en Cancérologie Digestive Database. J Clin Oncol. 2017 Jun 10; 35(17):1929-1937.
Renfro LA, Goldberg RM, Grothey A, Sobrero A, Adams R, Seymour MT, Heinemann V, Schmoll HJ, Douillard JY, Hurwitz H, Fuchs CS, Diaz-Rubio E, Porschen R, Tournigand C, Chibaudel B, Hoff PM, Kabbinavar FF, Falcone A, Tebbutt NC, Punt CJA, Hecht JR, Souglakos J, Bokemeyer C, Van Cutsem E, Saltz L, de Gramont A, Sargent DJ. PMID: 28414610.
View in: PubMed Mentions: 14 Fields: Translation: Humans
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Statistical controversies in clinical research: basket trials, umbrella trials, and other master protocols: a review and examples. Ann Oncol. 2017 01 01; 28(1):34-43.
PMID: 28177494.
View in: PubMed Mentions: 35 Fields: Translation: Humans
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Findings from the Adjuvant Colon Cancer End Points (ACCENT) Collaborative Group: the power of pooled individual patient data from multiple clinical trials. Chin Clin Oncol. 2016 Dec; 5(6):80.
PMID: 28061544.
View in: PubMed Mentions: 2 Fields: Translation: Humans
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Surrogate End Points in Soft Tissue Sarcoma: Methodologic Challenges. J Clin Oncol. 2016 11 10; 34(32):3949-3950.
PMID: 27551133.
View in: PubMed Mentions: 1 Fields: Translation: Humans
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Prospective Evaluation of a 12-Gene Assay on Patient Treatment Decisions and Physician Confidence in Mismatch Repair Proficient Stage IIA Colon Cancer. Clin Colorectal Cancer. 2017 03; 16(1):23-30.
PMID: 27600983.
View in: PubMed Mentions: 2 Fields: Translation: HumansCells
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Validity of Adjuvant! Online in older patients with stage III colon cancer based on 2967 patients from the ACCENT database. J Geriatr Oncol. 2016 11; 7(6):422-429.
PMID: 27468630.
View in: PubMed Mentions: 3 Fields: Translation: Humans
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Precision oncology: A new era of cancer clinical trials. Cancer Lett. 2017 02 28; 387:121-126.
PMID: 26987624.
View in: PubMed Mentions: 12 Fields: Translation: Humans
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Determinants of Early Mortality Among 37,568 Patients With Colon Cancer Who Participated in 25 Clinical Trials From the Adjuvant Colon Cancer Endpoints Database. J Clin Oncol. 2016 Apr 10; 34(11):1182-9.
PMID: 26858337.
View in: PubMed Mentions: 9 Fields: Translation: Humans
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Impact of Patient Factors on Recurrence Risk and Time Dependency of Oxaliplatin Benefit in Patients With Colon Cancer: Analysis From Modern-Era Adjuvant Studies in the Adjuvant Colon Cancer End Points (ACCENT) Database. J Clin Oncol. 2016 Mar 10; 34(8):843-53.
PMID: 26811529.
View in: PubMed Mentions: 32 Fields: Translation: Humans
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Clinical trial designs incorporating predictive biomarkers. Cancer Treat Rev. 2016 Feb; 43:74-82.
PMID: 26827695.
View in: PubMed Mentions: 16 Fields: Translation: Humans
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Body Mass Index Is Prognostic in Metastatic Colorectal Cancer: Pooled Analysis of Patients From First-Line Clinical Trials in the ARCAD Database. J Clin Oncol. 2016 Jan 10; 34(2):144-50.
PMID: 26503203.
View in: PubMed Mentions: 22 Fields: Translation: HumansCells
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Organ preservation for clinical T2N0 distal rectal cancer using neoadjuvant chemoradiotherapy and local excision (ACOSOG Z6041): results of an open-label, single-arm, multi-institutional, phase 2 trial. Lancet Oncol. 2015 Nov; 16(15):1537-1546.
PMID: 26474521.
View in: PubMed Mentions: 56 Fields: Translation: HumansCTClinical Trials
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Multitrial Evaluation of Progression-Free Survival as a Surrogate End Point for Overall Survival in First-Line Extensive-Stage Small-Cell Lung Cancer. J Thorac Oncol. 2015 Jul; 10(7):1099-106.
PMID: 26134227.
View in: PubMed Mentions: 12 Fields: Translation: HumansCTClinical Trials
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Survival following early-stage colon cancer: an ACCENT-based comparison of patients versus a matched international general population†. Ann Oncol. 2015 May; 26(5):950-958.
PMID: 25697217.
View in: PubMed Mentions: 3 Fields: Translation: Humans
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Impact of Copula Directional Specification on Multi-Trial Evaluation of Surrogate End Points. J Biopharm Stat. 2015; 25(4):857-77.
PMID: 24905465.
View in: PubMed Mentions: 3 Fields: Translation: Humans
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Projecting Event-Based Analysis Dates in Clinical Trials: An Illustration Based on the International Duration Evaluation of Adjuvant Chemotherapy (IDEA) Collaboration. Projecting analysis dates for the IDEA collaboration. Forum Clin Oncol. 2014 Dec; 5(2):1-7.
PMID: 26989447.
View in: PubMed Mentions:
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Comparative economics of a 12-gene assay for predicting risk of recurrence in stage II colon cancer. Pharmacoeconomics. 2014 Dec; 32(12):1231-43.
PMID: 25154747.
View in: PubMed Mentions: 3 Fields: Translation: Humans
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ACCENT-based web calculators to predict recurrence and overall survival in stage III colon cancer. J Natl Cancer Inst. 2014 Dec; 106(12).
PMID: 25359867.
View in: PubMed Mentions: 17 Fields: Translation: Humans
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MRE11-deficiency associated with improved long-term disease free survival and overall survival in a subset of stage III colon cancer patients in randomized CALGB 89803 trial. PLoS One. 2014; 9(10):e108483.
PMID: 25310185.
View in: PubMed Mentions: 7 Fields: Translation: Humans
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Center-Within-Trial Versus Trial-Level Evaluation of Surrogate Endpoints. Comput Stat Data Anal. 2014 Oct 01; 78:1-20.
PMID: 25061255.
View in: PubMed Mentions:
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Association of age with survival in patients with metastatic colorectal cancer: analysis from the ARCAD Clinical Trials Program. J Clin Oncol. 2014 Sep 20; 32(27):2975-84.
PMID: 25002720.
View in: PubMed Mentions: 25 Fields: Translation: Humans
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CpG island methylator phenotype is associated with response to adjuvant irinotecan-based therapy for stage III colon cancer. Gastroenterology. 2014 Sep; 147(3):637-45.
PMID: 24859205.
View in: PubMed Mentions: 47 Fields: Translation: HumansCellsCTClinical Trials
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Genetic markers of treatment response to tumour necrosis factor-a inhibitors in the treatment of psoriasis. Clin Exp Dermatol. 2014 Jun; 39(4):519-24.
PMID: 24758522.
View in: PubMed Mentions: 4 Fields: Translation: Humans
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Germline variation in colorectal risk Loci does not influence treatment effect or survival in metastatic colorectal cancer. PLoS One. 2014; 9(4):e94727.
PMID: 24727911.
View in: PubMed Mentions: 1 Fields: Translation: Humans
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Prospective multicenter study of the impact of oncotype DX colon cancer assay results on treatment recommendations in stage II colon cancer patients. Oncologist. 2014 May; 19(5):492-7.
PMID: 24710310.
View in: PubMed Mentions: 17 Fields: Translation: Humans
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Adaptive randomized phase II design for biomarker threshold selection and independent evaluation. Chin Clin Oncol. 2014 Mar 01; 3(1).
PMID: 25485277.
View in: PubMed Mentions: 3 Fields:
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Adaptive randomized phase II design for biomarker threshold selection and independent evaluation. Chin Clin Oncol. 2014 Mar; 3(1):3.
PMID: 25842081.
View in: PubMed Mentions: 1 Fields:
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Mining the ACCENT database: a review and update. Chin Clin Oncol. 2013 Jun; 2(2):18.
PMID: 25841498.
View in: PubMed Mentions: 3 Fields:
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Chronic consequences of acute injuries: worse survival after discharge. J Trauma Acute Care Surg. 2012 Sep; 73(3):699-703.
PMID: 22710768.
View in: PubMed Mentions: 5 Fields: Translation: Humans
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Bayesian adjusted R2 for the meta-analytic evaluation of surrogate time-to-event endpoints in clinical trials. Stat Med. 2012 Apr 13; 31(8):743-61.
PMID: 22161275.
View in: PubMed Mentions: 8 Fields: Translation: Humans
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Bayesian adaptive trial design for a newly validated surrogate endpoint. Biometrics. 2012 Mar; 68(1):258-67.
PMID: 21838811.
View in: PubMed Mentions: 3 Fields:
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Clinical and genetic predictors of response to narrowband ultraviolet B for the treatment of chronic plaque psoriasis. Br J Dermatol. 2010 Nov; 163(5):1056-63.
Ryan C, Renfro L, Collins P, Kirby B, Rogers S. PMID: 20716226.
View in: PubMed Mentions: 4 Fields: Translation: Humans
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Anatomical differences of port-wine stains in response to treatment with the pulsed dye laser. Arch Dermatol. 1993 Feb; 129(2):182-8.
Renfro L, Geronemus RG. PMID: 8434975.
View in: PubMed Mentions: 25 Fields: Translation: Humans
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Ulcerative lichen planus-like dermatitis associated with hydroxyurea. J Am Acad Dermatol. 1991 Jan; 24(1):143-5.
Renfro L, Kamino H, Raphael B, Moy J, Sanchez M. PMID: 1825667.
View in: PubMed Mentions: 1 Fields: Translation: Humans
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Year | Publications |
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1991 | 1 | 1993 | 1 | 2010 | 1 | 2011 | 2 | 2012 | 1 | 2013 | 1 | 2014 | 12 | 2015 | 5 | 2016 | 8 | 2017 | 6 | 2018 | 4 | 2019 | 3 | 2020 | 2 |
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