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Leo Mascarenhas, MD

Title(s)Associate Professor of Clinical Pediatrics
SchoolKeck School of Medicine of USC
Phone+1 323 361 2529
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    Other Positions
    Title(s)Section Head, Oncology

    Title(s)Director Solid Tumor Program

    Title(s)Director of Clinical Trials office


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    Leo Mascarenhas, MD is director of the Clinical Trials Office in the Children’s Center for Cancer and Blood Diseases and Principal Investigator for the National Cancer Institute funded Children’s Oncology Group grant at Children’s Hospital Los Angeles. He is an associate professor of Clinical Pediatrics at the Keck School of Medicine of the University of Southern California.

    Childhood cancer is the leading cause of disease-related death in pediatrics in the United States. Dr. Mascarenhas and his team's research focuses on developmental therapeutics for patients with bone and soft tissue sarcomas. Despite the remarkable progress made in the treatment of childhood cancer in the last four decades, improved therapies are still needed for our patients with a poor prognosis and less toxic therapies for those destined to survive. This can be accomplished only through basic, translational and clinical research.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Smeland S, Bielack SS, Whelan J, Bernstein M, Hogendoorn P, Krailo MD, Gorlick R, Janeway KA, Ingleby FC, Anninga J, Antal I, Arndt C, Brown KLB, Butterfass-Bahloul T, Calaminus G, Capra M, Dhooge C, Eriksson M, Flanagan AM, Friedel G, Gebhardt MC, Gelderblom H, Goldsby R, Grier HE, Grimer R, Hawkins DS, Hecker-Nolting S, Sundby Hall K, Isakoff MS, Jovic G, Kühne T, Kager L, von Kalle T, Kabickova E, Lang S, Lau CC, Leavey PJ, Lessnick SL, Mascarenhas L, Mayer-Steinacker R, Meyers PA, Nagarajan R, Randall RL, Reichardt P, Renard M, Rechnitzer C, Schwartz CL, Strauss S, Teot L, Timmermann B, Sydes MR, Marina N. Survival and prognosis with osteosarcoma: outcomes in more than 2000 patients in the EURAMOS-1 (European and American Osteosarcoma Study) cohort. Eur J Cancer. 2019 Jan 24; 109:36-50. PMID: 30685685.
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    2. DuBois SG, Laetsch TW, Federman N, Turpin BK, Albert CM, Nagasubramanian R, Anderson ME, Davis JL, Qamoos HE, Reynolds ME, Cruickshank S, Cox MC, Hawkins DS, Mascarenhas L, Pappo AS. The use of neoadjuvant larotrectinib in the management of children with locally advanced TRK fusion sarcomas. Cancer. 2018 Nov 01; 124(21):4241-4247. PMID: 30204247.
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    3. Shulman DS, Klega K, Imamovic-Tuco A, Clapp A, Nag A, Thorner AR, Van Allen E, Ha G, Lessnick SL, Gorlick R, Janeway KA, Leavey PJ, Mascarenhas L, London WB, Vo KT, Stegmaier K, Hall D, Krailo MD, Barkauskas DA, DuBois SG, Crompton BD. Detection of circulating tumour DNA is associated with inferior outcomes in Ewing sarcoma and osteosarcoma: a report from the Children's Oncology Group. Br J Cancer. 2018 Aug; 119(5):615-621. PMID: 30131550.
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    4. Hawkins DS, Chi YY, Anderson JR, Tian J, Arndt CAS, Bomgaars L, Donaldson SS, Hayes-Jordan A, Mascarenhas L, McCarville MB, McCune JS, McCowage G, Million L, Morris CD, Parham DM, Rodeberg DA, Rudzinski ER, Shnorhavorian M, Spunt SL, Skapek SX, Teot LA, Wolden S, Yock TI, Meyer WH. Addition of Vincristine and Irinotecan to Vincristine, Dactinomycin, and Cyclophosphamide Does Not Improve Outcome for Intermediate-Risk Rhabdomyosarcoma: A Report From the Children's Oncology Group. J Clin Oncol. 2018 Sep 20; 36(27):2770-2777. PMID: 30091945.
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    5. Drilon A, Laetsch TW, Kummar S, DuBois SG, Lassen UN, Demetri GD, Nathenson M, Doebele RC, Farago AF, Pappo AS, Turpin B, Dowlati A, Brose MS, Mascarenhas L, Federman N, Berlin J, El-Deiry WS, Baik C, Deeken J, Boni V, Nagasubramanian R, Taylor M, Rudzinski ER, Meric-Bernstam F, Sohal DPS, Ma PC, Raez LE, Hechtman JF, Benayed R, Ladanyi M, Tuch BB, Ebata K, Cruickshank S, Ku NC, Cox MC, Hawkins DS, Hong DS, Hyman DM. Efficacy of Larotrectinib in TRK Fusion-Positive Cancers in Adults and Children. N Engl J Med. 2018 02 22; 378(8):731-739. PMID: 29466156.
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    6. Moke DJ, Thomas SM, Hiemenz MC, Nael A, Wang K, Shillingford N, Biegel JA, Mascarenhas L. Three synchronous malignancies in a patient with DICER1 syndrome. Eur J Cancer. 2018 04; 93:140-143. PMID: 29395683.
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    7. Wang X, Sun CL, Hageman L, Smith K, Singh P, Desai S, Hawkins DS, Hudson MM, Mascarenhas L, Neglia JP, Oeffinger KC, Ritchey AK, Robison LL, Villaluna D, Landier W, Bhatia S. Clinical and Genetic Risk Prediction of Subsequent CNS Tumors in Survivors of Childhood Cancer: A Report From the COG ALTE03N1 Study. J Clin Oncol. 2017 Nov 10; 35(32):3688-3696. PMID: 28976792.
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    8. Zhou S, Venkatramani R, Gupta S, Wang K, Stein JE, Wang L, Mascarenhas L. Hepatocellular malignant neoplasm, NOS: a clinicopathological study of 11 cases from a single institution. Histopathology. 2017 Nov; 71(5):813-822. PMID: 28660626.
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    9. Setty BA, Stanek JR, Mascarenhas L, Miller A, Bagatell R, Okcu F, Nicholls L, Lysecki D, Gupta AA. VIncristine, irinotecan, and temozolomide in children and adolescents with relapsed rhabdomyosarcoma. Pediatr Blood Cancer. 2018 Jan; 65(1). PMID: 28748602.
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    10. Szymanski LJ, Molas-Torreblanca K, Bawab R, Kim E, Don D, Mascarenhas L, Stanley P, Zhou S, Shillingford N. Bronchial Mucoepidermoid Carcinoma With the Classic MAML2 Gene Rearrangement in a 2-year-old Boy. Pediatr Dev Pathol. 2018 Sep-Oct; 21(5):480-485. PMID: 28492094.
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    11. Ji J, Quindipan C, Parham D, Shen L, Ruble D, Bootwalla M, Maglinte DT, Gai X, Saitta SC, Biegel JA, Mascarenhas L. Inherited germline ATRX mutation in two brothers with ATR-X syndrome and osteosarcoma. Am J Med Genet A. 2017 May; 173(5):1390-1395. PMID: 28371217.
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    12. Landier W, Hageman L, Chen Y, Kornegay N, Evans WE, Bostrom BC, Casillas J, Dickens DS, Angiolillo AL, Lew G, Maloney KW, Mascarenhas L, Ritchey AK, Termuhlen AM, Carroll WL, Relling MV, Wong FL, Bhatia S. Mercaptopurine Ingestion Habits, Red Cell Thioguanine Nucleotide Levels, and Relapse Risk in Children With Acute Lymphoblastic Leukemia: A Report From the Children's Oncology Group Study AALL03N1. J Clin Oncol. 2017 May 20; 35(15):1730-1736. PMID: 28339328.
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    13. Landier W, Chen Y, Hageman L, Kim H, Bostrom BC, Casillas JN, Dickens DS, Evans WE, Maloney KW, Mascarenhas L, Ritchey AK, Termuhlen AM, Carroll WL, Relling MV, Wong FL, Bhatia S. Comparison of self-report and electronic monitoring of 6MP intake in childhood ALL: a Children's Oncology Group study. Blood. 2017 04 06; 129(14):1919-1926. PMID: 28153823.
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    14. Marina NM, Smeland S, Bielack SS, Bernstein M, Jovic G, Krailo MD, Hook JM, Arndt C, van den Berg H, Brennan B, Brichard B, Brown KLB, Butterfass-Bahloul T, Calaminus G, Daldrup-Link HE, Eriksson M, Gebhardt MC, Gelderblom H, Gerss J, Goldsby R, Goorin A, Gorlick R, Grier HE, Hale JP, Hall KS, Hardes J, Hawkins DS, Helmke K, Hogendoorn PCW, Isakoff MS, Janeway KA, Jürgens H, Kager L, Kühne T, Lau CC, Leavey PJ, Lessnick SL, Mascarenhas L, Meyers PA, Mottl H, Nathrath M, Papai Z, Randall RL, Reichardt P, Renard M, Safwat AA, Schwartz CL, Stevens MCG, Strauss SJ, Teot L, Werner M, Sydes MR, Whelan JS. Comparison of MAPIE versus MAP in patients with a poor response to preoperative chemotherapy for newly diagnosed high-grade osteosarcoma (EURAMOS-1): an open-label, international, randomised controlled trial. Lancet Oncol. 2016 Oct; 17(10):1396-1408. PMID: 27569442.
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    15. Reed DR, Mascarenhas L, Manning K, Hale GA, Goldberg J, Gill J, Sandler E, Isakoff MS, Smith T, Caracciolo J, Lush RM, Juan TH, Lee JK, Neuger AM, Sullivan DM. Pediatric phase I trial of oral sorafenib and topotecan in refractory or recurrent pediatric solid malignancies. Cancer Med. 2016 Feb; 5(2):294-303. PMID: 26714427.
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    16. Mascarenhas L, Felgenhauer JL, Bond MC, Villaluna D, Femino JD, Laack NN, Ranganathan S, Meyer J, Womer RB, Gorlick R, Krailo MD, Marina N. Pilot Study of Adding Vincristine, Topotecan, and Cyclophosphamide to Interval-Compressed Chemotherapy in Newly Diagnosed Patients With Localized Ewing Sarcoma: A Report From the Children's Oncology Group. Pediatr Blood Cancer. 2016 Mar; 63(3):493-8. PMID: 26579879; PMCID: PMC4860347 [Available on 03/01/17].
      View in: PubMed, PubMed Central
    17. De A, Mascarenhas L, Kamath S, LaRiviere A, Goodarzian F, Keens TG, Venkatramani R. Pilot Feasibility Study of Comprehensive Pulmonary Evaluation Following Lung Radiation Therapy. J Pediatr Hematol Oncol. 2015 Oct; 37(7):e412-8. PMID: 26241727; PMCID: PMC4573838 [Available on 10/01/16].
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    18. Chien MC, Mascarenhas L, Hammoudeh JA, Venkatramani R. Zoledronic Acid for the Treatment of Children With Refractory Central Giant Cell Granuloma. J Pediatr Hematol Oncol. 2015 Aug; 37(6):e399-401. PMID: 26056788.
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    19. Venkatramani R, Triche TJ, Wang L, Shimada H, Mascarenhas L. Insulin-like Growth Factor 2 Gene Expression Molecularly Differentiates Pleuropulmonary Blastoma and Embryonal Rhabdomyosarcoma. J Pediatr Hematol Oncol. 2015 Aug; 37(6):e356-60. PMID: 26056800; PMCID: PMC4506202.
      View in: PubMed, PubMed Central
    20. Bhatia S, Landier W, Hageman L, Chen Y, Kim H, Sun CL, Kornegay N, Evans WE, Angiolillo AL, Bostrom B, Casillas J, Lew G, Maloney KW, Mascarenhas L, Ritchey AK, Termuhlen AM, Carroll WL, Wong FL, Relling MV. Systemic Exposure to Thiopurines and Risk of Relapse in Children With Acute Lymphoblastic Leukemia: A Children's Oncology Group Study. JAMA Oncol. 2015 Jun; 1(3):287-95. PMID: 26181173; PMCID: PMC4561178.
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    21. Chan R, Mascarenhas L, Boles RG, Kerkar N, Genyk Y, Venkatramani R. Hepatoblastoma in a patient with methylmalonic aciduria. Am J Med Genet A. 2015 Mar; 167A(3):635-8. PMID: 25691417.
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    22. HaDuong JH, Martin AA, Skapek SX, Mascarenhas L. Sarcomas. Pediatr Clin North Am. 2015 Feb; 62(1):179-200. PMID: 25435119.
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    23. Zhou S, Gomulia E, Mascarenhas L, Wang L. Is INI1-retained small cell undifferentiated histology in hepatoblastoma unfavorable? Hum Pathol. 2015 Apr; 46(4):620-4. PMID: 25649007.
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    24. Tran HC, Marachelian A, Venkatramani R, Jubran RF, Mascarenhas L. Oxaliplatin and Doxorubicin for relapsed or refractory high-risk neuroblastoma. Pediatr Hematol Oncol. 2015 Feb; 32(1):26-31. PMID: 25551355.
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    25. Su A, Low L, Li X, Zhou S, Mascarenhas L, Barnhill RL. De novo congenital melanoma: analysis of 2 cases with array comparative genomic hybridization. Am J Dermatopathol. 2014 Nov; 36(11):915-9. PMID: 25051103.
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    26. Venkatramani R, Mascarenhas L. Successful treatment of recurrent metastatic nasopharyngeal carcinoma with oxaliplatin and doxorubicin. J Pediatr Hematol Oncol. 2014 Jul; 36(5):e307-9. PMID: 24276035.
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    27. Armenian SH, Gelehrter SK, Vase T, Venkatramani R, Landier W, Wilson KD, Herrera C, Reichman L, Menteer JD, Mascarenhas L, Freyer DR, Venkataraman K, Bhatia S. Screening for cardiac dysfunction in anthracycline-exposed childhood cancer survivors. Clin Cancer Res. 2014 Dec 15; 20(24):6314-23. PMID: 24947931; PMCID: PMC4268342.
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    28. De A, Guryev I, LaRiviere A, Kato R, Wee CP, Mascarenhas L, Keens TG, Venkatramani R. Pulmonary function abnormalities in childhood cancer survivors treated with bleomycin. Pediatr Blood Cancer. 2014 Sep; 61(9):1679-84. PMID: 24789770.
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    29. Venkatramani R, Shoureshi P, Malvar J, Zhou S, Mascarenhas L. High dose alkylator therapy for extracranial malignant rhabdoid tumors in children. Pediatr Blood Cancer. 2014 Aug; 61(8):1357-61. PMID: 24789740.
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    30. Armenian SH, Gelehrter SK, Vase T, Venkatramani R, Landier W, Wilson KD, Herrera C, Reichman L, Menteer JD, Mascarenhas L, Freyer DR, Venkataraman K, Bhatia S. Carnitine and cardiac dysfunction in childhood cancer survivors treated with anthracyclines. Cancer Epidemiol Biomarkers Prev. 2014 Jun; 23(6):1109-14. PMID: 24718281; PMCID: PMC4053243.
      View in: PubMed, PubMed Central
    31. De A, Kamath S, Wong K, Olch AJ, Malvar J, Sposto R, Mascarenhas L, Keens TG, Venkatramani R. Correlation of pulmonary function abnormalities with dose volume histograms in children treated with lung irradiation. Pediatr Pulmonol. 2015 Jun; 50(6):596-603. PMID: 24644268.
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    32. Venkatramani R, Kamath S, Wong K, Olch AJ, Malvar J, Sposto R, Goodarzian F, Freyer DR, Keens TG, Mascarenhas L. Pulmonary outcomes in patients with Hodgkin lymphoma treated with involved field radiation. Pediatr Blood Cancer. 2014 Jul; 61(7):1277-81. PMID: 24482138.
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    33. Puliyel MM, Mascarenhas L, Zhou S, Sapra A, Dal Cin P, French CA, Venkatramani R. Nuclear protein in testis midline carcinoma misdiagnosed as adamantinoma. J Clin Oncol. 2014 May 20; 32(15):e57-60. PMID: 24470009; PMCID: PMC4876346.
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    34. Chan R, Mascarenhas L, Venkatramani R. Hepatoblastoma and hypoplastic kidneys: a new association. Pediatr Blood Cancer. 2014 Aug; 61(8):1476-8. PMID: 24623570.
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    35. Shah R, Tran HC, Randolph L, Mascarenhas L, Venkatramani R. Hepatoblastoma in a 15-month-old female with trisomy 13. Am J Med Genet A. 2014 Feb; 164A(2):472-5. PMID: 24311532.
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    36. Venkatramani R, Malogolowkin MH, Mascarenhas L. Treatment of multiply relapsed wilms tumor with vincristine, irinotecan, temozolomide and bevacizumab. Pediatr Blood Cancer. 2014 Apr; 61(4):756-9. PMID: 24115645.
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    37. Mehta B, Mascarenhas L, Zhou S, Wang L, Venkatramani R. Inflammatory myofibroblastic tumors in childhood. Pediatr Hematol Oncol. 2013 Oct; 30(7):640-5. PMID: 23988029.
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    38. Venkatramani R, Malogolowkin M, Davidson TB, May W, Sposto R, Mascarenhas L. A phase I study of vincristine, irinotecan, temozolomide and bevacizumab (vitb) in pediatric patients with relapsed solid tumors. PLoS One. 2013; 8(7):e68416. PMID: 23894304; PMCID: PMC3718768.
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    39. Venkatramani R, Kamath S, Wong K, Olch AJ, Malvar J, Sposto R, Goodarzian F, Freyer DR, Keens TG, Mascarenhas L. Correlation of clinical and dosimetric factors with adverse pulmonary outcomes in children after lung irradiation. Int J Radiat Oncol Biol Phys. 2013 Aug 01; 86(5):942-8. PMID: 23726005.
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    40. Arkader A, Myung KS, Stanley P, Mascarenhas L. Ewing sarcoma of the tibia mimicking fibrous dysplasia. J Pediatr Orthop B. 2013 May; 22(3):222-7. PMID: 22094991.
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    41. Ibrahim DA, Mascarenhas L, Tovar JP, Arkader A. Orthopaedic case of the month: A 14-year-old boy with a medial thigh soft tissue mass. Clin Orthop Relat Res. 2013 May; 471(5):1433-8. PMID: 23129475; PMCID: PMC3613539.
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    42. Mascarenhas L, Malogolowkin M, Armenian SH, Sposto R, Venkatramani R. A phase I study of oxaliplatin and doxorubicin in pediatric patients with relapsed or refractory extracranial non-hematopoietic solid tumors. Pediatr Blood Cancer. 2013 Jul; 60(7):1103-7. PMID: 23335436; PMCID: PMC3815656.
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    43. Venkatramani R, Malogolowkin MH, Wang L, Mascarenhas L. Pleuropulmonary blastoma: a single-institution experience. J Pediatr Hematol Oncol. 2012 Jul; 34(5):e182-5. PMID: 22584785.
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    44. Bhatia S, Landier W, Shangguan M, Hageman L, Schaible AN, Carter AR, Hanby CL, Leisenring W, Yasui Y, Kornegay NM, Mascarenhas L, Ritchey AK, Casillas JN, Dickens DS, Meza J, Carroll WL, Relling MV, Wong FL. Nonadherence to oral mercaptopurine and risk of relapse in Hispanic and non-Hispanic white children with acute lymphoblastic leukemia: a report from the children's oncology group. J Clin Oncol. 2012 Jun 10; 30(17):2094-101. PMID: 22564992; PMCID: PMC3601449.
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    45. Venkatramani R, Wang L, Malvar J, Dias D, Sposto R, Malogolowkin MH, Mascarenhas L. Tumor necrosis predicts survival following neo-adjuvant chemotherapy for hepatoblastoma. Pediatr Blood Cancer. 2012 Sep; 59(3):493-8. PMID: 22190448.
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    46. Venkatramani R, Olch AJ, Mascarenhas L, Yoon S, Suterwala B, Mehta B, Wong K. Correlation of long-term pulmonary injury with radiation dose distribution in childhood cancer survivors. Pract Radiat Oncol. 2012 Jul-Sep; 2(3):237-240. PMID: 24674127.
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    47. Hingorani P, Seidel K, Krailo M, Mascarenhas L, Meyers P, Marina N, Conrad EU, Hawkins DS. Body mass index (BMI) at diagnosis is associated with surgical wound complications in patients with localized osteosarcoma: a report from the Children's Oncology Group. Pediatr Blood Cancer. 2011 Dec 01; 57(6):939-42. PMID: 21480474; PMCID: PMC3135763.
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    48. Mascarenhas L, Bond MC, Seibel NL. Expanded Access Through Cancer Trials Support Unit to Children's Oncology Group Sarcoma Trial AEWS1031 for Adolescents and Young Adults. J Adolesc Young Adult Oncol. 2011 Mar; 1(1):61-3. PMID: 26812570; PMCID: PMC4976716.
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    49. Venkatramani R, Ma NS, Pitukcheewanont P, Malogolowkin MH, Mascarenhas L. Gorham's disease and diffuse lymphangiomatosis in children and adolescents. Pediatr Blood Cancer. 2011 Apr; 56(4):667-70. PMID: 21298758.
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    50. Mascarenhas L, Lyden ER, Breitfeld PP, Walterhouse DO, Donaldson SS, Paidas CN, Parham DM, Anderson JR, Meyer WH, Hawkins DS. Randomized phase II window trial of two schedules of irinotecan with vincristine in patients with first relapse or progression of rhabdomyosarcoma: a report from the Children's Oncology Group. J Clin Oncol. 2010 Oct 20; 28(30):4658-63. PMID: 20837952.
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    51. Rovelo MO, Kim R, Mascarenhas L, Hammoudeh J, Urata MM. Recurrent and refractory giant cell tumor of the jaw. J Craniofac Surg. 2009 Nov; 20(6):2245-8. PMID: 19934683.
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    52. Imran H, Enders F, Krailo M, Sim F, Okuno S, Hawkins D, Neglia J, Randall RL, Womer R, Mascarenhas L, Arndt CA. Effect of time to resumption of chemotherapy after definitive surgery on prognosis for non-metastatic osteosarcoma. J Bone Joint Surg Am. 2009 Mar 01; 91(3):604-12. PMID: 19255220; PMCID: PMC2701597.
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    53. Leavey PJ, Mascarenhas L, Marina N, Chen Z, Krailo M, Miser J, Brown K, Tarbell N, Bernstein ML, Granowetter L, Gebhardt M, Grier HE. Prognostic factors for patients with Ewing sarcoma (EWS) at first recurrence following multi-modality therapy: A report from the Children's Oncology Group. Pediatr Blood Cancer. 2008 Sep; 51(3):334-8. PMID: 18506764; PMCID: PMC2728357.
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    54. Armenian SH, Hoffman JA, Butturini AM, Kapoor N, Mascarenhas L. Invasive diagnostic procedures for pulmonary infiltrates in pediatric hematopoietic stem cell transplant recipients. Pediatr Transplant. 2007 Nov; 11(7):736-42. PMID: 17910650.
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    55. Madigan CE, Armenian SH, Malogolowkin MH, Mascarenhas L. Extracranial malignant rhabdoid tumors in childhood: the Childrens Hospital Los Angeles experience. Cancer. 2007 Nov 01; 110(9):2061-6. PMID: 17828773.
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    56. Yoon JM, Burns RC, Malogolowkin MH, Mascarenhas L. Treatment of infantile choriocarcinoma of the liver. Pediatr Blood Cancer. 2007 Jul; 49(1):99-102. PMID: 16206190.
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    57. Harned TM, Mascarenhas L. Severe methotrexate toxicity precipitated by intravenous radiographic contrast. J Pediatr Hematol Oncol. 2007 Jul; 29(7):496-9. PMID: 17609630.
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    58. Armenian SH, La Via WV, Siegel SE, Mascarenhas L. Evaluation of persistent pulmonary infiltrates in pediatric oncology patients. Pediatr Blood Cancer. 2007 Feb; 48(2):165-72. PMID: 16411212.
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    59. Wu SQ, Loh KT, Chen XR, Joo WJ, Mascarenhas L. Transient myeloproliferative disorder in a phenotypically normal infant with i(21q) mosaicism. Cancer Genet Cytogenet. 2002 Jul 15; 136(2):138-40. PMID: 12237238.
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