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Kinji Asahina, PhD

Title(s)Associate Professor of Research Pathology
SchoolKeck School of Medicine of USC
Phone+1 323 442 2213
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    Collapse Research 
    Collapse Research Activities and Funding
    Roles of lysophosphatidic acid in alcoholic liver disease
    NIH/NIAAA R21AA027222Jan 10, 2019 - Dec 31, 2020
    Role: Principal Investigator
    Dissection of Glisson's capsule in alcohol induced liver injury
    NIH/NIAAA R21AA024840Aug 20, 2016 - Jul 31, 2018
    Role: Principal Investigator
    Contribution of the mesothelium to alcohol-induced liver fibrosis
    NIH/NIAAA R01AA020753Sep 1, 2011 - Jul 31, 2016
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Ogawa T, Li Y, Lua I, Hartner A, Asahina K. Isolation of a unique hepatic stellate cell population expressing integrin a8 from embryonic mouse livers. Dev Dyn. 2018 Jun; 247(6):867-881. PMID: 29665133.
      View in: PubMed
    2. Nguyen MV, Zagory JA, Dietz WH, Park A, Fenlon M, Zhao M, Xu J, Lua I, Mavila N, Asahina K, Wang KS. Hepatic Prominin-1 expression is associated with biliary fibrosis. Surgery. 2017 05; 161(5):1266-1272. PMID: 28104292.
      View in: PubMed
    3. He L, Gubbins J, Peng Z, Medina V, Fei F, Asahina K, Wang J, Kahn M, Rountree CB, Stiles BL. Activation of hepatic stellate cell in Pten null liver injury model. Fibrogenesis Tissue Repair. 2016; 9:8. PMID: 27307790; PMCID: PMC4908727.
    4. Lua I, Asahina K. The Role of Mesothelial Cells in Liver Development, Injury, and Regeneration. Gut Liver. 2016 Mar; 10(2):166-76. PMID: 26934883; PMCID: PMC4780447.
    5. Lua I, Li Y, Zagory JA, Wang KS, French SW, Sévigny J, Asahina K. Characterization of hepatic stellate cells, portal fibroblasts, and mesothelial cells in normal and fibrotic livers. J Hepatol. 2016 May; 64(5):1137-1146. PMID: 26806818; PMCID: PMC4834254 [Available on 05/01/17].
    6. Li Y, Lua I, French SW, Asahina K. Role of TGF-ß signaling in differentiation of mesothelial cells to vitamin A-poor hepatic stellate cells in liver fibrosis. Am J Physiol Gastrointest Liver Physiol. 2016 Feb 15; 310(4):G262-72. PMID: 26702136; PMCID: PMC4754741 [Available on 02/15/17].
    7. Lua I, Li Y, Pappoe LS, Asahina K. Myofibroblastic Conversion and Regeneration of Mesothelial Cells in Peritoneal and Liver Fibrosis. Am J Pathol. 2015 Dec; 185(12):3258-73. PMID: 26598235; PMCID: PMC4729239 [Available on 12/01/16].
    8. Li Y, Lua I, Asahina K. MACS Isolation and Culture of Mouse Liver Mesothelial Cells. Bio Protoc. 2015 Jul 05; 3(13). PMID: 27430003.
      View in: PubMed
    9. Mavila N, James D, Shivakumar P, Nguyen MV, Utley S, Mak K, Wu A, Zhou S, Wang L, Vendyres C, Groff M, Asahina K, Wang KS. Expansion of prominin-1-expressing cells in association with fibrosis of biliary atresia. Hepatology. 2014 Sep; 60(3):941-53. PMID: 24798639; PMCID: PMC4146699.
    10. Inokuchi-Shimizu S, Park EJ, Roh YS, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W, Mackey MR, Akira S, Ellisman MH, Sears DD, Olefsky JM, Karin M, Brenner DA, Seki E. TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. J Clin Invest. 2014 Aug; 124(8):3566-78. PMID: 24983318; PMCID: PMC4109552.
    11. Lua I, James D, Wang J, Wang KS, Asahina K. Mesodermal mesenchymal cells give rise to myofibroblasts, but not epithelial cells, in mouse liver injury. Hepatology. 2014 Jul; 60(1):311-22. PMID: 24488807; PMCID: PMC4077971.
    12. Yin C, Evason KJ, Asahina K, Stainier DY. Hepatic stellate cells in liver development, regeneration, and cancer. J Clin Invest. 2013 May; 123(5):1902-10. PMID: 23635788.
      View in: PubMed
    13. Li Y, Wang J, Asahina K. Mesothelial cells give rise to hepatic stellate cells and myofibroblasts via mesothelial-mesenchymal transition in liver injury. Proc Natl Acad Sci U S A. 2013 Feb 05; 110(6):2324-9. PMID: 23345421; PMCID: PMC3568296.
    14. Ozeki R, Kakinuma S, Asahina K, Shimizu-Saito K, Arii S, Tanaka Y, Teraoka H. Hepatic stellate cells mediate differentiation of dendritic cells from monocytes. J Med Dent Sci. 2012 Mar 13; 59(1):43-52. PMID: 23896963.
      View in: PubMed
    15. Asahina K. Hepatic stellate cell progenitor cells. J Gastroenterol Hepatol. 2012 Mar; 27 Suppl 2:80-4. PMID: 22320922; PMCID: PMC3281558.
    16. Tsukamoto H, Zhu NL, Wang J, Asahina K, Machida K. Morphogens and hepatic stellate cell fate regulation in chronic liver disease. J Gastroenterol Hepatol. 2012 Mar; 27 Suppl 2:94-8. PMID: 22320925; PMCID: PMC3337168.
    17. Yang MD, Chiang YM, Higashiyama R, Asahina K, Mann DA, Mann J, Wang CC, Tsukamoto H. Rosmarinic acid and baicalin epigenetically derepress peroxisomal proliferator-activated receptor ? in hepatic stellate cells for their antifibrotic effect. Hepatology. 2012 Apr; 55(4):1271-81. PMID: 22095555; PMCID: PMC3302956.
    18. Zhu NL, Asahina K, Wang J, Ueno A, Lazaro R, Miyaoka Y, Miyajima A, Tsukamoto H. Hepatic stellate cell-derived delta-like homolog 1 (DLK1) protein in liver regeneration. J Biol Chem. 2012 Mar 23; 287(13):10355-67. PMID: 22298767; PMCID: PMC3322997.
    19. DeLeve LD, Jaeschke H, Kalra VK, Asahina K, Brenner DA, Tsukamoto H. 15th International Symposium on Cells of the Hepatic Sinusoid, 2010. Liver Int. 2011 Jul; 31(6):762-72. PMID: 21645207; PMCID: PMC4388239.
    20. Tsukamoto H, Zhu NL, Asahina K, Mann DA, Mann J. Epigenetic cell fate regulation of hepatic stellate cells. Hepatol Res. 2011 Jul; 41(7):675-82. PMID: 21504520; PMCID: PMC4321904.
    21. Asahina K, Zhou B, Pu WT, Tsukamoto H. Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver. Hepatology. 2011 Mar; 53(3):983-95. PMID: 21294146; PMCID: PMC3078645.
    22. Asahina K, Tsai SY, Li P, Ishii M, Maxson RE, Sucov HM, Tsukamoto H. Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development. Hepatology. 2009 Mar; 49(3):998-1011. PMID: 19085956; PMCID: PMC2673117.
    23. Shikanai M, Asahina K, Iseki S, Teramoto K, Nishida T, Shimizu-Saito K, Ota M, Eto K, Teraoka H. A novel method of mouse ex utero transplantation of hepatic progenitor cells into the fetal liver. Biochem Biophys Res Commun. 2009 Apr 03; 381(2):276-82. PMID: 19217885.
      View in: PubMed
    24. Gaucher G, Asahina K, Wang J, Leroux JC. Effect of poly(N-vinyl-pyrrolidone)-block-poly(D,L-lactide) as coating agent on the opsonization, phagocytosis, and pharmacokinetics of biodegradable nanoparticles. Biomacromolecules. 2009 Feb 09; 10(2):408-16. PMID: 19133718.
      View in: PubMed
    25. Machida K, Tsukamoto H, Mkrtchyan H, Duan L, Dynnyk A, Liu HM, Asahina K, Govindarajan S, Ray R, Ou JH, Seki E, Deshaies R, Miyake K, Lai MM. Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog. Proc Natl Acad Sci U S A. 2009 Feb 03; 106(5):1548-53. PMID: 19171902; PMCID: PMC2635765.
    26. Fujimori H, Asahina K, Shimizu-Saito K, Ikeda R, Tanaka Y, Teramoto K, Morita I, Teraoka H. Vascular endothelial growth factor promotes proliferation and function of hepatocyte-like cells in embryoid bodies formed from mouse embryonic stem cells. J Hepatol. 2008 Jun; 48(6):962-73. PMID: 18384904.
      View in: PubMed
    27. Ikeda R, Nishida T, Watanabe F, Shimizu-Saito K, Asahina K, Horikawa S, Teraoka H. Involvement of CCAAT/enhancer binding protein-beta (C/EBPbeta) in epigenetic regulation of mouse methionine adenosyltransferase 1A gene expression. Int J Biochem Cell Biol. 2008; 40(9):1956-69. PMID: 18346930.
      View in: PubMed
    28. Irie T, Asahina K, Shimizu-Saito K, Teramoto K, Arii S, Teraoka H. Hepatic progenitor cells in the mouse extrahepatic bile duct after a bile duct ligation. Stem Cells Dev. 2007 Dec; 16(6):979-87. PMID: 18004941.
      View in: PubMed
    29. Cheng JH, She H, Han YP, Wang J, Xiong S, Asahina K, Tsukamoto H. Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis. Am J Physiol Gastrointest Liver Physiol. 2008 Jan; 294(1):G39-49. PMID: 18006602.
      View in: PubMed
    30. Masaki H, Nishida T, Kitajima S, Asahina K, Teraoka H. Developmental pluripotency-associated 4 (DPPA4) localized in active chromatin inhibits mouse embryonic stem cell differentiation into a primitive ectoderm lineage. J Biol Chem. 2007 Nov 09; 282(45):33034-42. PMID: 17855347.
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    31. Kida Y, Asahina K, Inoue K, Kawada N, Yoshizato K, Wake K, Sato T. Characterization of vitamin A-storing cells in mouse fibrous kidneys using Cygb/STAP as a marker of activated stellate cells. Arch Histol Cytol. 2007 Jul; 70(2):95-106. PMID: 17827667.
      View in: PubMed
    32. Kida Y, Asahina K, Teraoka H, Gitelman I, Sato T. Twist relates to tubular epithelial-mesenchymal transition and interstitial fibrogenesis in the obstructed kidney. J Histochem Cytochem. 2007 Jul; 55(7):661-73. PMID: 17341474.
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    33. Kakinuma S, Asahina K, Okamura K, Teramoto K, Tateno C, Yoshizato K, Tanaka Y, Yasumizu T, Sakamoto N, Watanabe M, Teraoka H. Human cord blood cells transplanted into chronically damaged liver exhibit similar characteristics to functional hepatocytes. Transplant Proc. 2007 Jan-Feb; 39(1):240-3. PMID: 17275513.
      View in: PubMed
    34. Ogawa T, Tateno C, Asahina K, Fujii H, Kawada N, Obara M, Yoshizato K. Identification of vitamin A-free cells in a stellate cell-enriched fraction of normal rat liver as myofibroblasts. Histochem Cell Biol. 2007 Feb; 127(2):161-74. PMID: 17024455.
      View in: PubMed
    35. Asahina K, Teramoto K, Teraoka H. Embryonic stem cells: hepatic differentiation and regenerative medicine for the treatment of liver disease. Curr Stem Cell Res Ther. 2006 May; 1(2):139-56. PMID: 18220863.
      View in: PubMed
    36. Sakasai R, Shinohe K, Ichijima Y, Okita N, Shibata A, Asahina K, Teraoka H. Differential involvement of phosphatidylinositol 3-kinase-related protein kinases in hyperphosphorylation of replication protein A2 in response to replication-mediated DNA double-strand breaks. Genes Cells. 2006 Mar; 11(3):237-46. PMID: 16483312.
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    37. Asahina K, Shiokawa M, Ueki T, Yamasaki C, Aratani A, Tateno C, Yoshizato K. Multiplicative mononuclear small hepatocytes in adult rat liver: their isolation as a homogeneous population and localization to periportal zone. Biochem Biophys Res Commun. 2006 Apr 21; 342(4):1160-7. PMID: 16516159.
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    38. Ichijima Y, Sakasai R, Okita N, Asahina K, Mizutani S, Teraoka H. Phosphorylation of histone H2AX at M phase in human cells without DNA damage response. Biochem Biophys Res Commun. 2005 Oct 28; 336(3):807-12. PMID: 16153602.
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    39. Emoto K, Tateno C, Hino H, Amano H, Imaoka Y, Asahina K, Asahara T, Yoshizato K. Efficient in vivo xenogeneic retroviral vector-mediated gene transduction into human hepatocytes. Hum Gene Ther. 2005 Oct; 16(10):1168-74. PMID: 16218778.
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    40. Okamura K, Asahina K, Fujimori H, Ozeki R, Shimizu-Saito K, Tanaka Y, Teramoto K, Arii S, Takase K, Kataoka M, Soeno Y, Tateno C, Yoshizato K, Teraoka H. Generation of hybrid hepatocytes by cell fusion from monkey embryoid body cells in the injured mouse liver. Histochem Cell Biol. 2006 Mar; 125(3):247-57. PMID: 16195892.
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    41. Kumashiro Y, Asahina K, Ozeki R, Shimizu-Saito K, Tanaka Y, Kida Y, Inoue K, Kaneko M, Sato T, Teramoto K, Arii S, Teraoka H. Enrichment of hepatocytes differentiated from mouse embryonic stem cells as a transplantable source. Transplantation. 2005 Mar 15; 79(5):550-7. PMID: 15753844.
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    42. Teramoto K, Hara Y, Kumashiro Y, Chinzei R, Tanaka Y, Shimizu-Saito K, Asahina K, Teraoka H, Arii S. Teratoma formation and hepatocyte differentiation in mouse liver transplanted with mouse embryonic stem cell-derived embryoid bodies. Transplant Proc. 2005 Jan-Feb; 37(1):285-6. PMID: 15808620.
      View in: PubMed
    43. Teramoto K, Asahina K, Kumashiro Y, Kakinuma S, Chinzei R, Shimizu-Saito K, Tanaka Y, Teraoka H, Arii S. Hepatocyte differentiation from embryonic stem cells and umbilical cord blood cells. J Hepatobiliary Pancreat Surg. 2005; 12(3):196-202. PMID: 15995807.
      View in: PubMed
    44. Kumashiro Y, Teramoto K, Shimizu-Saito K, Asahina K, Teraoka H, Arii S. Isolation of hepatocyte-like cells from mouse embryoid body cells. Transplant Proc. 2005 Jan-Feb; 37(1):299-300. PMID: 15808625.
      View in: PubMed
    45. Asahina K, Fujimori H, Shimizu-Saito K, Kumashiro Y, Okamura K, Tanaka Y, Teramoto K, Arii S, Teraoka H. Expression of the liver-specific gene Cyp7a1 reveals hepatic differentiation in embryoid bodies derived from mouse embryonic stem cells. Genes Cells. 2004 Dec; 9(12):1297-308. PMID: 15569160.
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    46. Tateno C, Yoshizane Y, Saito N, Kataoka M, Utoh R, Yamasaki C, Tachibana A, Soeno Y, Asahina K, Hino H, Asahara T, Yokoi T, Furukawa T, Yoshizato K. Near completely humanized liver in mice shows human-type metabolic responses to drugs. Am J Pathol. 2004 Sep; 165(3):901-12. PMID: 15331414; PMCID: PMC1618591.
    47. Asahina K, Kawada N, Kristensen DB, Nakatani K, Seki S, Shiokawa M, Tateno C, Obara M, Yoshizato K. Characterization of human stellate cell activation-associated protein and its expression in human liver. Biochim Biophys Acta. 2002 Sep 27; 1577(3):471-5. PMID: 12359339.
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    48. Asahina K, Sato H, Yamasaki C, Kataoka M, Shiokawa M, Katayama S, Tateno C, Yoshizato K. Pleiotrophin/heparin-binding growth-associated molecule as a mitogen of rat hepatocytes and its role in regeneration and development of liver. Am J Pathol. 2002 Jun; 160(6):2191-205. PMID: 12057922; PMCID: PMC1850835.
    49. Kawada N, Kristensen DB, Asahina K, Nakatani K, Minamiyama Y, Seki S, Yoshizato K. Characterization of a stellate cell activation-associated protein (STAP) with peroxidase activity found in rat hepatic stellate cells. J Biol Chem. 2001 Jul 06; 276(27):25318-23. PMID: 11320098.
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    50. Utoh R, Asahina K, Suzuki K, Kotani K, Obara M, Yoshizato K. Developmentally and regionally regulated participation of epidermal cells in the formation of collagen lamella of anuran tadpole skin. Dev Growth Differ. 2000 Dec; 42(6):571-80. PMID: 11142679.
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    51. Oomizu S, Sahuc F, Asahina K, Inamatsu M, Matsuzaki T, Sasaki M, Obara M, Yoshizato K. Kdap, a novel gene associated with the stratification of the epithelium. Gene. 2000 Oct 03; 256(1-2):19-27. PMID: 11054531.
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    52. Asahina K, Obara M, Yoshizato K. Expression of genes of type I and type II collagen in the formation and development of the blastema of regenerating newt limb. Dev Dyn. 1999 Sep; 216(1):59-71. PMID: 10474166.
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    53. Asahina K, Utoh R, Obara M, Yoshizato K. Cell-type specific and thyroid hormone-dependent expression of genes of alpha1(I) and alpha2(I) collagen in intestine during amphibian metamorphosis. Matrix Biol. 1999 Feb; 18(1):89-103. PMID: 10367734.
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    54. Asahina K, Oofusa K, Obara M, Yoshizato K. Cloning and characterization of the full length cDNA encoding alpha2 type I collagen of bullfrog Rana catesbeiana. Gene. 1997 Jul 31; 194(2):283-9. PMID: 9272872.
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