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Kelvin J. A. Davies, PhD, DSc

Title(s)Distinguished Professor, Executive Vice Dean, Dean of Faculty and Research, and Director of the Andrus Gerontology Center for the USC Leonard Davis School of Gerontology
Address3715 McClintock Avenue, GER 112A
University Park Campus
Los Angeles CA 90089-0191
Phone+1 213 740 8959
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    Collapse Biography 
    Collapse Awards and Honors
    University of Gdansk 199550th Anniversary Medal
    Society for Free Radical Biology & Medicine2006Lifetime Scientific Achievement Award
    Society for Free Radical Biology & Medicine2006Lifetime Scientific Achievement Award
    American College of Sports Medicine2007Presidential Award

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    Kelvin J. A. Davies, Ph.D., D.Sc. is the James E. Birren Chair of Gerontology. Professor Davies was born and raised in London, England and is a dual citizen of Great Britain and the U.S.A. Educated at London University, Liverpool & Lancaster Universities, the University of Wisconsin, the University of California at Berkeley, and Harvard, he was previously a faculty member at Harvard University and Harvard Medical School. Before moving to USC’s Andrus Gerontology Center in 1996, Professor Davies was Chairman of the Department of Biochemistry & Molecular Biology at the Albany Medical College in New York, where he was also John A. Muntz University Professor and Distinguished Professor of Molecular Medicine.

    Deeply involved in research into oxidative stress and free radicals, Professor Davies is the (founding) Editor-in-Chief of the premier scientific journal in the field, Free Radical Biology & Medicine. Professor Davies is a Fellow of the Oxygen Society; a Fellow of the Society for Free Radical Biology & Medicine; a Fellow of the Gerontological Society of America; a Fellow of the American Association for the Advancement of Science; a Fellow of the Royal Institution (London); winner of the Harwood S. Belding award of the American Physiological Society; and holder of various medals, honorary degrees, and fellowships from several universities and scientific societies. Professor Davies is past President of the Society for Free Radical Biology & Medicine and the International Society for Free Radical Research. In 1996, he was named the National Parkinson Foundation Scholar. Recently he was awarded the Gold Medal of the European Society for Free Radical Research, and in 2012 Professor Davies was knighted as a Chevalier de l’Ordre National du Mérite de France (Knight, National Order of Merit of France) by the President of France.

    During aging, and in several age-related disease processes, vital cellular proteins, lipids, and DNA and RNA are damaged by free radicals produced by metabolism, chronic inflammation, radiation, smoke, pollution, and by many foods and drugs. These oxidized, non-functional, or dysfunctional cellular constituents must be removed or repaired before they cause further cell damage.

    Professor Davies’ research centers on the role of free radicals and oxidative stress in biology. In particular he is interested in genes that repair oxidatively damaged proteins, lipids, RNA, and DNA, and his laboratory has made major contributions to our understanding of this subject over the past twenty years. At the Andrus Gerontology Center, Professor Davies is focusing his research on the regulation of oxidative stress repair genes during aging. His laboratory is involved in biochemical, molecular biology, and genetic studies of both normal aging processes, and aging pathologies such as Alzheimer and Huntington diseases.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Sex differences in the response to oxidative and proteolytic stress. Redox Biol. 2020 Apr; 31:101488. Tower J, Pomatto LCD, Davies KJA. PMID: 32201219.
      View in: PubMed   Mentions: 1     Fields:    
    2. Silencing Bach1 alters aging-related changes in the expression of Nrf2-regulated genes in primary human bronchial epithelial cells. Arch Biochem Biophys. 2019 09 15; 672:108074. Zhang H, Zhou L, Davies KJA, Forman HJ. PMID: 31422075.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Measuring redox effects on the activities of intracellular proteases such as the 20S Proteasome and the Immuno-Proteasome with fluorogenic peptides. Free Radic Biol Med. 2019 11 01; 143:16-24. Bonet-Costa V, Sun PY, Davies KJA. PMID: 31351175.
      View in: PubMed   Mentions:    Fields:    
    4. Limitations to adaptive homeostasis in an hyperoxia-induced model of accelerated ageing. Redox Biol. 2019 06; 24:101194. Pomatto LCD, Sun PY, Yu K, Gullapalli S, Bwiza CP, Sisliyan C, Wong S, Zhang H, Forman HJ, Oliver PL, Davies KE, Davies KJA. PMID: 31022673.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    5. Sex-specific stress tolerance, proteolysis, and lifespan in the invertebrate Tigriopus californicus. Exp Gerontol. 2019 05; 119:146-156. Foley HB, Sun PY, Ramirez R, So BK, Venkataraman YR, Nixon EN, Davies KJA, Edmands S. PMID: 30738921.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    6. Free radicals and redox regulation in ageing. Free Radic Biol Med. 2019 04; 134:688-689. Davies KJA. PMID: 30710634.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    7. Does Bach1 & c-Myc dependent redox dysregulation of Nrf2 & adaptive homeostasis decrease cancer risk in ageing? Free Radic Biol Med. 2019 04; 134:708-714. Davies KJA, Forman HJ. PMID: 30695691.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    8. Adaptive homeostasis and the free radical theory of ageing. Free Radic Biol Med. 2018 08 20; 124:420-430. Pomatto LCD, Davies KJA. PMID: 29960100.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    9. Rust never sleeps: The continuing story of the Iron Bolt. Free Radic Biol Med. 2018 08 20; 124:353-357. van der Vliet A, Dick TP, Aust SD, Koppenol WH, Ursini F, Kettle AJ, Beckman JS, O'Donnell V, Darley-Usmar V, Lancaster J, Hogg N, Davies KJA, Forman HJ, Janssen-Heininger YMW. PMID: 29913216.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. The role of oxidative stress in anxiety disorder: cause or consequence? Free Radic Res. 2018 Jul; 52(7):737-750. Fedoce ADG, Ferreira F, Bota RG, Bonet-Costa V, Sun PY, Davies KJA. PMID: 29742940.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    11. To adapt or not to adapt: Consequences of declining Adaptive Homeostasis and Proteostasis with age. Mech Ageing Dev. 2019 01; 177:80-87. Pomatto LCD, Sun PY, Davies KJA. PMID: 29778759.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    12. Cardiovascular Adaptive Homeostasis in Exercise. Front Physiol. 2018; 9:369. Davies KJA. PMID: 29765327.
      View in: PubMed   Mentions:
    13. Aging attenuates redox adaptive homeostasis and proteostasis in female mice exposed to traffic-derived nanoparticles ('vehicular smog'). Free Radic Biol Med. 2018 06; 121:86-97. Pomatto LCD, Cline M, Woodward N, Pakbin P, Sioutas C, Morgan TE, Finch CE, Forman HJ, Davies KJA. PMID: 29709705.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    14. Sex-specific adaptive homeostasis in D. melanogaster depends on increased proteolysis by the 20S Proteasome: Data-in-Brief. Data Brief. 2018 Apr; 17:653-661. Pomatto LCD, Wong S, Tower J, Davies KJA. PMID: 29552615.
      View in: PubMed   Mentions:
    15. Sexual Dimorphism and Aging Differentially Regulate Adaptive Homeostasis. J Gerontol A Biol Sci Med Sci. 2018 01 16; 73(2):141-149. Pomatto LCD, Tower J, Davies KJA. PMID: 28525535.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    16. Redox Regulation of Homeostasis and Proteostasis in Peroxisomes. Physiol Rev. 2018 01 01; 98(1):89-115. Walker CL, Pomatto LCD, Tripathi DN, Davies KJA. PMID: 29167332.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    17. The Oxygen Paradox, the French Paradox, and age-related diseases. Geroscience. 2017 12; 39(5-6):499-550. Davies JMS, Cillard J, Friguet B, Cadenas E, Cadet J, Cayce R, Fishmann A, Liao D, Bulteau AL, Derbré F, Rébillard A, Burstein S, Hirsch E, Kloner RA, Jakowec M, Petzinger G, Sauce D, Sennlaub F, Limon I, Ursini F, Maiorino M, Economides C, Pike CJ, Cohen P, Salvayre AN, Halliday MR, Lundquist AJ, Jakowec NA, Mechta-Grigoriou F, Mericskay M, Mariani J, Li Z, Huang D, Grant E, Forman HJ, Finch CE, Sun PY, Pomatto LCD, Agbulut O, Warburton D, Neri C, Rouis M, Cillard P, Capeau J, Rosenbaum J, Davies KJA. PMID: 29270905.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    18. The role of declining adaptive homeostasis in ageing. J Physiol. 2017 12 15; 595(24):7275-7309. Pomatto LCD, Davies KJA. PMID: 29028112.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    19. Sexual dimorphism in oxidant-induced adaptive homeostasis in multiple wild-type D. melanogaster strains. Arch Biochem Biophys. 2017 12 15; 636:57-70. Pomatto LCD, Wong S, Tower J, Davies KJA. PMID: 29100984.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    20. Diminished stress resistance and defective adaptive homeostasis in age-related diseases. Clin Sci (Lond). 2017 Nov 01; 131(21):2573-2599. Lomeli N, Bota DA, Davies KJA. PMID: 29070521.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    21. Aging-related decline in the induction of Nrf2-regulated antioxidant genes in human bronchial epithelial cells. Redox Biol. 2018 04; 14:35-40. Zhou L, Zhang H, Davies KJA, Forman HJ. PMID: 28863281.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    22. SIRT1 may play a crucial role in overload-induced hypertrophy of skeletal muscle. J Physiol. 2017 06 01; 595(11):3361-3376. Koltai E, Bori Z, Chabert C, Dubouchaud H, Naito H, Machida S, Davies KJ, Murlasits Z, Fry AC, Boldogh I, Radak Z. PMID: 28251652.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    23. The age- and sex-specific decline of the 20s proteasome and the Nrf2/CncC signal transduction pathway in adaption and resistance to oxidative stress in Drosophila melanogaster. Aging (Albany NY). 2017 04; 9(4):1153-1185. Pomatto LCD, Wong S, Carney C, Shen B, Tower J, Davies KJA. PMID: 28373600.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    24. Oxidative DNA damage & repair: An introduction. Free Radic Biol Med. 2017 06; 107:2-12. Cadet J, Davies KJA. PMID: 28363603.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    25. Formation and repair of oxidatively generated damage in cellular DNA. Free Radic Biol Med. 2017 06; 107:13-34. Cadet J, Davies KJA, Medeiros MH, Di Mascio P, Wagner JR. PMID: 28057600.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    26. The Mitochondrial Lon Protease Is Required for Age-Specific and Sex-Specific Adaptation to Oxidative Stress. Curr Biol. 2017 Jan 09; 27(1):1-15. Pomatto LCD, Carney C, Shen B, Wong S, Halaszynski K, Salomon MP, Davies KJA, Tower J. PMID: 27916526.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    27. The Proteasome and Oxidative Stress in Alzheimer's Disease. Antioxid Redox Signal. 2016 12 01; 25(16):886-901. Bonet-Costa V, Pomatto LC, Davies KJ. PMID: 27392670.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    28. Corrigendum to "What is the concentration of hydrogen peroxide in blood and plasma?" [Arch. Biochem. Biophys. 603 (2016) 48-53]. Arch Biochem Biophys. 2016 Oct 01; 607:7. Forman HJ, Bernardo A, Davies KJ. PMID: 27552737.
      View in: PubMed   Mentions: 1     Fields:    
    29. The molecular chaperone Hsp70 promotes the proteolytic removal of oxidatively damaged proteins by the proteasome. Free Radic Biol Med. 2016 10; 99:153-166. Reeg S, Jung T, Castro JP, Davies KJA, Henze A, Grune T. PMID: 27498116.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    30. Mitochondrial Lon protease in human disease and aging: Including an etiologic classification of Lon-related diseases and disorders. Free Radic Biol Med. 2016 11; 100:188-198. Bota DA, Davies KJ. PMID: 27387767.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    31. Aging and SKN-1-dependent Loss of 20S Proteasome Adaptation to Oxidative Stress in C. elegans. J Gerontol A Biol Sci Med Sci. 2017 02; 72(2):143-151. Raynes R, Juarez C, Pomatto LC, Sieburth D, Davies KJ. PMID: 27341854.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    32. What is the concentration of hydrogen peroxide in blood and plasma? Arch Biochem Biophys. 2016 08 01; 603:48-53. Forman HJ, Bernardo A, Davies KJ. PMID: 27173735.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    33. Degradation of oxidized proteins by the proteasome: Distinguishing between the 20S, 26S, and immunoproteasome proteolytic pathways. Mol Aspects Med. 2016 08; 50:41-55. Raynes R, Pomatto LC, Davies KJ. PMID: 27155164.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    34. Adaptive homeostasis. Mol Aspects Med. 2016 06; 49:1-7. Davies KJ. PMID: 27112802.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    35. The Immunoproteasome in oxidative stress, aging, and disease. Crit Rev Biochem Mol Biol. 2015 Jul-Aug; 51(4):268-81. Johnston-Carey HK, Pomatto LC, Davies KJ. PMID: 27098648.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    36. The Oxygen Paradox, oxidative stress, and ageing. Arch Biochem Biophys. 2016 Apr 01; 595:28-32. Davies KJ. PMID: 27095211.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    37. Transit of H2O2 across the endoplasmic reticulum membrane is not sluggish. Free Radic Biol Med. 2016 05; 94:157-60. Appenzeller-Herzog C, Bánhegyi G, Bogeski I, Davies KJ, Delaunay-Moisan A, Forman HJ, Görlach A, Kietzmann T, Laurindo F, Margittai E, Meyer AJ, Riemer J, Rützler M, Simmen T, Sitia R, Toledano MB, Touw IP. PMID: 26928585.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    38. The peroxisomal Lon protease LonP2 in aging and disease: functions and comparisons with mitochondrial Lon protease LonP1. Biol Rev Camb Philos Soc. 2017 May; 92(2):739-753. Pomatto LC, Raynes R, Davies KJ. PMID: 26852705.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    39. Commentary on "Bach1 differentially regulates distinct Nrf2-dependent genes in human venous and coronary artery endothelial cells adapted to physiological oxygen levels" by Chapple et al. Free Radic Biol Med. 2016 Mar; 92:163-164. Forman HJ, Davies KJA. PMID: 26802904.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    40. The calcineurin antagonist RCAN1-4 is induced by exhaustive exercise in rat skeletal muscle. Free Radic Biol Med. 2015 Oct; 87:290-9. Emrani R, Rébillard A, Lefeuvre L, Gratas-Delamarche A, Davies KJ, Cillard J. PMID: 26122706.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    41. Oxidative stress response and Nrf2 signaling in aging. Free Radic Biol Med. 2015 Nov; 88(Pt B):314-336. Zhang H, Davies KJA, Forman HJ. PMID: 26066302.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    42. TGFß1 rapidly activates Src through a non-canonical redox signaling mechanism. Arch Biochem Biophys. 2015 Feb 15; 568:1-7. Zhang H, Davies KJ, Forman HJ. PMID: 25585026.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    43. Acute Electrical Pulse Stimulation and Hyperglycemia Regulates RCAN1-4 in C2C12 myotubes through Oxidative Stress. Free Radic Biol Med. 2014 Oct; 75 Suppl 1:S29. Emrani Bidi R, Rebillard A, Saligaut D, Delamarche A, Davies KJ, Cillard J. PMID: 26461328.
      View in: PubMed   Mentions:    Fields:    
    44. What Goes Wrong with Lon in Ageing? Free Radic Biol Med. 2014 Oct; 75 Suppl 1:S6. Davies KJ. PMID: 26461412.
      View in: PubMed   Mentions: 1     Fields:    
    45. Even free radicals should follow some rules: a guide to free radical research terminology and methodology. Free Radic Biol Med. 2015 Jan; 78:233-5. Forman HJ, Augusto O, Brigelius-Flohe R, Dennery PA, Kalyanaraman B, Ischiropoulos H, Mann GE, Radi R, Roberts LJ, Vina J, Davies KJ. PMID: 25462642.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    46. Mitochondrial biogenesis-associated factors underlie the magnitude of response to aerobic endurance training in rats. Pflugers Arch. 2015 Apr; 467(4):779-88. Marton O, Koltai E, Takeda M, Koch LG, Britton SL, Davies KJ, Boldogh I, Radak Z. PMID: 24943897.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    47. Reactive oxygen and nitrogen species in neurodegeneration. Free Radic Biol Med. 2013 Sep; 62:1-3. Andersen JK, Davies KJA, Forman HJ. PMID: 23876468.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    48. How do nutritional antioxidants really work: nucleophilic tone and para-hormesis versus free radical scavenging in vivo. Free Radic Biol Med. 2014 Jan; 66:24-35. Forman HJ, Davies KJ, Ursini F. PMID: 23747930.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    49. Resveratrol attenuates exercise-induced adaptive responses in rats selectively bred for low running performance. Dose Response. 2014 Jan; 12(1):57-71. Hart N, Sarga L, Csende Z, Koch LG, Britton SL, Davies KJ, Radak Z. PMID: 24659933.
      View in: PubMed   Mentions:
    50. Resveratrol enhances exercise training responses in rats selectively bred for high running performance. Food Chem Toxicol. 2013 Nov; 61:53-9. Hart N, Sarga L, Csende Z, Koltai E, Koch LG, Britton SL, Davies KJ, Kouretas D, Wessner B, Radak Z. PMID: 23422033.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    51. Upregulation of the mitochondrial Lon Protease allows adaptation to acute oxidative stress but dysregulation is associated with chronic stress, disease, and aging. Redox Biol. 2013 Feb 09; 1:258-64. Ngo JK, Pomatto LC, Davies KJ. PMID: 24024159.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    52. Chronic high levels of the RCAN1-1 protein may promote neurodegeneration and Alzheimer disease. Free Radic Biol Med. 2013 Sep; 62:47-51. Ermak G, Davies KJA. PMID: 23369757.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    53. Competition of nuclear factor-erythroid 2 factors related transcription factor isoforms, Nrf1 and Nrf2, in antioxidant enzyme induction. Redox Biol. 2013; 1:183-9. Chepelev NL, Zhang H, Liu H, McBride S, Seal AJ, Morgan TE, Finch CE, Willmore WG, Davies KJ, Forman HJ. PMID: 24024152.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    54. A conserved role for the 20S proteasome and Nrf2 transcription factor in oxidative stress adaptation in mammals, Caenorhabditis elegans and Drosophila melanogaster. J Exp Biol. 2013 Feb 15; 216(Pt 4):543-53. Pickering AM, Staab TA, Tower J, Sieburth D, Davies KJ. PMID: 23038734.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    55. Age-associated declines in mitochondrial biogenesis and protein quality control factors are minimized by exercise training. Am J Physiol Regul Integr Comp Physiol. 2012 Jul 15; 303(2):R127-34. Koltai E, Hart N, Taylor AW, Goto S, Ngo JK, Davies KJ, Radak Z. PMID: 22573103.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    56. Differential roles of proteasome and immunoproteasome regulators Pa28aß, Pa28? and Pa200 in the degradation of oxidized proteins. Arch Biochem Biophys. 2012 Jul 15; 523(2):181-90. Pickering AM, Davies KJ. PMID: 22564544.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    57. Nrf2-regulated phase II enzymes are induced by chronic ambient nanoparticle exposure in young mice with age-related impairments. Free Radic Biol Med. 2012 May 01; 52(9):2038-46. Zhang H, Liu H, Davies KJ, Sioutas C, Finch CE, Morgan TE, Forman HJ. PMID: 22401859.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    58. Chronic expression of RCAN1-1L protein induces mitochondrial autophagy and metabolic shift from oxidative phosphorylation to glycolysis in neuronal cells. J Biol Chem. 2012 Apr 20; 287(17):14088-98. Ermak G, Sojitra S, Yin F, Cadenas E, Cuervo AM, Davies KJ. PMID: 22389495.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    59. Cigarette smoke extract stimulates epithelial-mesenchymal transition through Src activation. Free Radic Biol Med. 2012 Apr 15; 52(8):1437-42. Zhang H, Liu H, Borok Z, Davies KJ, Ursini F, Forman HJ. PMID: 22342303.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    60. Nrf2-dependent induction of proteasome and Pa28aß regulator are required for adaptation to oxidative stress. J Biol Chem. 2012 Mar 23; 287(13):10021-31. Pickering AM, Linder RA, Zhang H, Forman HJ, Davies KJ. PMID: 22308036.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
    61. Degradation of damaged proteins: the main function of the 20S proteasome. Prog Mol Biol Transl Sci. 2012; 109:227-48. Pickering AM, Davies KJ. PMID: 22727423.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    62. Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations. Free Radic Biol Med. 2012 Jan 01; 52(1):1-6. Kalyanaraman B, Darley-Usmar V, Davies KJ, Dennery PA, Forman HJ, Grisham MB, Mann GE, Moore K, Roberts LJ, Ischiropoulos H. PMID: 22027063.
      View in: PubMed   Mentions: 331     Fields:    Translation:Cells
    63. A simple fluorescence labeling method for studies of protein oxidation, protein modification, and proteolysis. Free Radic Biol Med. 2012 Jan 15; 52(2):239-46. Pickering AM, Davies KJ. PMID: 21988844.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    64. Impairment of lon-induced protection against the accumulation of oxidized proteins in senescent wi-38 fibroblasts. J Gerontol A Biol Sci Med Sci. 2011 Nov; 66(11):1178-85. Ngo JK, Pomatto LC, Bota DA, Koop AL, Davies KJ. PMID: 21868393.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    65. HSP70 mediates dissociation and reassociation of the 26S proteasome during adaptation to oxidative stress. Free Radic Biol Med. 2011 Oct 01; 51(7):1355-64. Grune T, Catalgol B, Licht A, Ermak G, Pickering AM, Ngo JK, Davies KJ. PMID: 21767633.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansCells
    66. Do RCAN1 proteins link chronic stress with neurodegeneration? FASEB J. 2011 Oct; 25(10):3306-11. Ermak G, Pritchard MA, Dronjak S, Niu B, Davies KJ. PMID: 21680892.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    67. RasGrf1 and aging. Aging (Albany NY). 2011 May; 3(5):455. Davies KJ, Forman HJ. PMID: 21666282.
      View in: PubMed   Mentions: 2     Fields:    
    68. Amyloid-ß toxicity and tau hyperphosphorylation are linked via RCAN1 in Alzheimer's disease. J Alzheimers Dis. 2011; 27(4):701-9. Lloret A, Badia MC, Giraldo E, Ermak G, Alonso MD, Pallardó FV, Davies KJ, Viña J. PMID: 21876249.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    69. The immunoproteasome, the 20S proteasome and the PA28aß proteasome regulator are oxidative-stress-adaptive proteolytic complexes. Biochem J. 2010 Dec 15; 432(3):585-94. Pickering AM, Koop AL, Teoh CY, Ermak G, Grune T, Davies KJ. PMID: 20919990.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansAnimalsCells
    70. The evolution of Free Radical Biology & Medicine: still radical after a quarter of a century! Free Radic Biol Med. 2010 Dec 15; 49(12):1825-33. Davies KJ. PMID: 21146787.
      View in: PubMed   Mentions: 1     Fields:    
    71. Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli. EMBO Mol Med. 2010 Dec; 2(12):490-503. Costa V, Giacomello M, Hudec R, Lopreiato R, Ermak G, Lim D, Malorni W, Davies KJ, Carafoli E, Scorrano L. PMID: 21069748.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    72. Protein oxidative modifications in the ageing brain: consequence for the onset of neurodegenerative disease. Free Radic Res. 2011 Jan; 45(1):73-88. Grimm S, Hoehn A, Davies KJ, Grune T. PMID: 20815785.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    73. Tau protein degradation is catalyzed by the ATP/ubiquitin-independent 20S proteasome under normal cell conditions. Arch Biochem Biophys. 2010 Aug 15; 500(2):181-8. Grune T, Botzen D, Engels M, Voss P, Kaiser B, Jung T, Grimm S, Ermak G, Davies KJ. PMID: 20478262.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
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    80. Is vitamin E an antioxidant, a regulator of signal transduction and gene expression, or a 'junk' food? Comments on the two accompanying papers: "Molecular mechanism of alpha-tocopherol action" by A. Azzi and "Vitamin E, antioxidant and nothing more" by M. Traber and J. Atkinson. Free Radic Biol Med. 2007 Jul 01; 43(1):2-3. Brigelius-Flohé R, Davies KJ. PMID: 17561087.
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    93. Oxidized and ubiquitinated proteins may predict recovery of postischemic cardiac function: essential role of the proteasome. Antioxid Redox Signal. 2005 May-Jun; 7(5-6):538-46. Powell SR, Wang P, Katzeff H, Shringarpure R, Teoh C, Khaliulin I, Das DK, Davies KJ, Schwalb H. PMID: 15889999.
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    97. Potential roles of protein oxidation and the immunoproteasome in MHC class I antigen presentation: the 'PrOxI' hypothesis. Arch Biochem Biophys. 2004 Mar 01; 423(1):88-96. Teoh CY, Davies KJ. PMID: 14871471.
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    100. Genetic aberrations in Chernobyl-related thyroid cancers: implications for possible future nuclear accidents or nuclear attacks. IUBMB Life. 2003 Dec; 55(12):637-41. Ermak G, Figge JJ, Kartel NA, Davies KJ. PMID: 14768999.
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    102. Tyrosine oxidation products: analysis and biological relevance. Amino Acids. 2003 Dec; 25(3-4):227-32. Giulivi C, Traaseth NJ, Davies KJ. PMID: 14661086.
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    103. Cytotoxic effect of doxycycline and its implications for tet-on gene expression systems. Anal Biochem. 2003 Jul 01; 318(1):152-4. Ermak G, Cancasci VJ, Davies KJ. PMID: 12782044.
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    104. Selective degradation of oxidatively modified protein substrates by the proteasome. Biochem Biophys Res Commun. 2003 Jun 06; 305(3):709-18. Grune T, Merker K, Sandig G, Davies KJ. PMID: 12763051.
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    105. Proteasome inhibitors induce intracellular protein aggregation and cell death by an oxygen-dependent mechanism. FEBS Lett. 2003 May 08; 542(1-3):89-94. Demasi M, Davies KJ. PMID: 12729904.
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    107. Characterization of adapt33, a stress-inducible riboregulator. Gene Expr. 2003; 11(2):85-94. Wang Y, Davies KJ, Melendez JA, Crawford DR. PMID: 12837039.
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    109. Ubiquitin conjugation is not required for the degradation of oxidized proteins by proteasome. J Biol Chem. 2003 Jan 03; 278(1):311-8. Shringarpure R, Grune T, Mehlhase J, Davies KJ. PMID: 12401807.
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    112. Atherosclerosis: another protein misfolding disease? Trends Mol Med. 2002 Aug; 8(8):370-4. Ursini F, Davies KJ, Maiorino M, Parasassi T, Sevanian A. PMID: 12127722.
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    118. Differential display: a critical analysis. Gene Expr. 2002; 10(3):101-7. Crawford DR, Kochheiser JC, Schools GP, Salmon SL, Davies KJ. PMID: 12064572.
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    128. 4-Hydroxynonenal-modified amyloid-beta peptide inhibits the proteasome: possible importance in Alzheimer's disease. Cell Mol Life Sci. 2000 Nov; 57(12):1802-9. Shringarpure R, Grune T, Sitte N, Davies KJ. PMID: 11130184.
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    162. Assessing gene expression during oxidative stress. Methods Enzymol. 1994; 234:175-217. Crawford DR, Edbauer-Nechamen CA, Lowry CV, Salmon SL, Kim YK, Davies JM, Davies KJ. PMID: 7528871.
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    163. Potential roles of hypochlorous acid and N-chloroamines in collagen breakdown by phagocytic cells in synovitis. Free Radic Biol Med. 1993 Dec; 15(6):637-43. Davies JM, Horwitz DA, Davies KJ. PMID: 8138190.
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    164. Hydrophobicity as the signal for selective degradation of hydroxyl radical-modified hemoglobin by the multicatalytic proteinase complex, proteasome. J Biol Chem. 1993 Jul 25; 268(21):15405-11. Pacifici RE, Kono Y, Davies KJ. PMID: 8393440.
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    165. Protein modification by oxidants and the role of proteolytic enzymes. Biochem Soc Trans. 1993 May; 21(2):346-53. Davies KJ. PMID: 8359494.
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    166. Dityrosine and tyrosine oxidation products are endogenous markers for the selective proteolysis of oxidatively modified red blood cell hemoglobin by (the 19 S) proteasome. J Biol Chem. 1993 Apr 25; 268(12):8752-9. Giulivi C, Davies KJ. PMID: 8473319.
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    167. Serum urate as an antioxidant for ascorbic acid. Am J Clin Nutr. 1991 12; 54(6 Suppl):1129S-1134S. Sevanian A, Davies KJ, Hochstein P. PMID: 1962559.
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    168. Phospholipid hydroperoxide glutathione peroxidase is the 18-kDa selenoprotein expressed in human tumor cell lines. J Biol Chem. 1991 Apr 25; 266(12):7728-32. Maiorino M, Chu FF, Ursini F, Davies KJ, Doroshow JH, Esworthy RS. PMID: 2019596.
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    169. Protein, lipid and DNA repair systems in oxidative stress: the free-radical theory of aging revisited. Gerontology. 1991; 37(1-3):166-80. Pacifici RE, Davies KJ. PMID: 2055497.
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    170. HSP70 and other possible heat shock or oxidative stress proteins are induced in skeletal muscle, heart, and liver during exercise. Free Radic Biol Med. 1991; 11(3):239-46. Salo DC, Donovan CM, Davies KJ. PMID: 1937141.
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    171. A novel antioxidant role for hemoglobin. The comproportionation of ferrylhemoglobin with oxyhemoglobin. J Biol Chem. 1990 Nov 15; 265(32):19453-60. Giulivi C, Davies KJ. PMID: 2174037.
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    172. The oxidative inactivation of mitochondrial electron transport chain components and ATPase. J Biol Chem. 1990 Sep 25; 265(27):16330-6. Zhang Y, Marcillat O, Giulivi C, Ernster L, Davies KJ. PMID: 2168888.
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    173. Superoxide dismutase undergoes proteolysis and fragmentation following oxidative modification and inactivation. J Biol Chem. 1990 Jul 15; 265(20):11919-27. Salo DC, Pacifici RE, Lin SW, Giulivi C, Davies KJ. PMID: 2195028.
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    174. Protein oxidation and proteolytic degradation. General aspects and relationship to cataract formation. Adv Exp Med Biol. 1990; 264:503-11. Davies KJ. PMID: 2244532.
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    175. Protein degradation as an index of oxidative stress. Methods Enzymol. 1990; 186:485-502. Pacifici RE, Davies KJ. PMID: 2233315.
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    176. Lens proteasome shows enhanced rates of degradation of hydroxyl radical modified alpha-crystallin. Free Radic Biol Med. 1990; 8(3):217-22. Murakami K, Jahngen JH, Lin SW, Davies KJ, Taylor A. PMID: 2341052.
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    177. Oxidative and non-oxidative mechanisms in the inactivation of cardiac mitochondrial electron transport chain components by doxorubicin. Biochem J. 1989 Apr 01; 259(1):181-9. Marcillat O, Zhang Y, Davies KJ. PMID: 2719642.
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    178. Macroxyproteinase (M.O.P.): a 670 kDa proteinase complex that degrades oxidatively denatured proteins in red blood cells. Free Radic Biol Med. 1989; 7(5):521-36. Pacifici RE, Salo DC, Davies KJ. PMID: 2558981.
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    179. The inhibition of bacterial growth by hypochlorous acid. Possible role in the bactericidal activity of phagocytes. Biochem J. 1988 Sep 15; 254(3):685-92. McKenna SM, Davies KJ. PMID: 2848494.
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    180. Mitochondria contain a proteolytic system which can recognize and degrade oxidatively-denatured proteins. Biochem J. 1988 Sep 15; 254(3):677-83. Marcillat O, Zhang Y, Lin SW, Davies KJ. PMID: 3196285.
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    181. The measurement of protein degradation in response to oxidative stress. Basic Life Sci. 1988; 49:531-5. Pacifici RE, Lin SW, Davies KJ. PMID: 3074786.
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    182. A secondary antioxidant defense role for proteolytic systems. Basic Life Sci. 1988; 49:575-85. Davies KJ. PMID: 3074788.
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    183. Oxidatively denatured proteins are degraded by an ATP-independent proteolytic pathway in Escherichia coli. Free Radic Biol Med. 1988; 5(4):225-36. Davies KJ, Lin SW. PMID: 3075950.
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    184. Bacterial killing by phagocytes: potential role(s) of hypochlorous acid and hydrogen peroxide in protein turnover, DNA synthesis, and RNA synthesis. Basic Life Sci. 1988; 49:829-32. McKenna SM, Davies KJ. PMID: 2471506.
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    185. Superoxide dismutase is preferentially degraded by a proteolytic system from red blood cells following oxidative modification by hydrogen peroxide. Free Radic Biol Med. 1988; 5(5-6):335-9. Salo DC, Lin SW, Pacifici RE, Davies KJ. PMID: 2476367.
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    186. Degradation of oxidatively denatured proteins in Escherichia coli. Free Radic Biol Med. 1988; 5(4):215-23. Davies KJ, Lin SW. PMID: 2908182.
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    187. Protein damage and degradation by oxygen radicals. II. Modification of amino acids. J Biol Chem. 1987 Jul 15; 262(20):9902-7. Davies KJ, Delsignore ME, Lin SW. PMID: 3036876.
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    188. Protein damage and degradation by oxygen radicals. IV. Degradation of denatured protein. J Biol Chem. 1987 Jul 15; 262(20):9914-20. Davies KJ, Lin SW, Pacifici RE. PMID: 3036878.
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    189. Protein oxidation and loss of protease activity may lead to cataract formation in the aged lens. Free Radic Biol Med. 1987; 3(6):371-7. Taylor A, Davies KJ. PMID: 3322949.
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    190. Redox cycling of anthracyclines by cardiac mitochondria. I. Anthracycline radical formation by NADH dehydrogenase. J Biol Chem. 1986 Mar 05; 261(7):3060-7. Davies KJ, Doroshow JH. PMID: 3456345.
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    191. Redox cycling of anthracyclines by cardiac mitochondria. II. Formation of superoxide anion, hydrogen peroxide, and hydroxyl radical. J Biol Chem. 1986 Mar 05; 261(7):3068-74. Doroshow JH, Davies KJ. PMID: 3005279.
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    192. Intracellular proteolytic systems may function as secondary antioxidant defenses: an hypothesis. J Free Radic Biol Med. 1986; 2(3):155-73. Davies KJ. PMID: 3553299.
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    193. Distinguishing effects of anemia and muscle iron deficiency on exercise bioenergetics in the rat. Am J Physiol. 1984 Jun; 246(6 Pt 1):E535-43. Davies KJ, Donovan CM, Refino CJ, Brooks GA, Packer L, Dallman PR. PMID: 6742115.
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    194. Mitochondrial NADH dehydrogenase-catalyzed oxygen radical production by adriamycin, and the relative inactivity of 5-iminodaunorubicin. FEBS Lett. 1983 Mar 07; 153(1):227-30. Davies KJ, Doroshow JH, Hochstein P. PMID: 6298008.
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    195. Free radicals and tissue damage produced by exercise. Biochem Biophys Res Commun. 1982 Aug 31; 107(4):1198-205. Davies KJ, Quintanilha AT, Brooks GA, Packer L. PMID: 6291524.
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    196. Muscle mitochondrial bioenergetics, oxygen supply, and work capacity during dietary iron deficiency and repletion. Am J Physiol. 1982 Jun; 242(6):E418-27. Davies KJ, Maguire JJ, Brooks GA, Dallman PR, Packer L. PMID: 7091311.
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    197. Exercise bioenergetics following sprint training. Arch Biochem Biophys. 1982 Apr 15; 215(1):260-5. Davies KJ, Packer L, Brooks GA. PMID: 7092228.
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    198. Effects of dietary iron deficiency of iron-sulfur proteins and bioenergetic functions of skeletal muscle mitochondria. Biochim Biophys Acta. 1982 Feb 17; 679(2):210-20. Maguire JJ, Davies KJ, Dallman PR, Packer L. PMID: 7059584.
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    199. Membrane effects of vitamin E deficiency: bioenergetic and surface charge density studies of skeletal muscle and liver mitochondria. Ann N Y Acad Sci. 1982; 393:32-47. Quintanilha AT, Packer L, Davies JM, Racanelli TL, Davies KJ. PMID: 6959560.
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    200. Biochemical adaptation of mitochondria, muscle, and whole-animal respiration to endurance training. Arch Biochem Biophys. 1981 Jul; 209(2):539-54. Davies KJ, Packer L, Brooks GA. PMID: 7294809.
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