Kelvin J. A. Davies, PhD, DSc

Title(s)Distinguished Professor, Executive Vice Dean, Dean of Faculty and Research, and Director of the Andrus Gerontology Center for the USC Leonard Davis School of Gerontology
Address3715 McClintock Avenue, GER 112A
University Park Campus
Los Angeles CA 90089-0191
Phone+1 213 740 8959
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    Collapse Biography 
    Collapse Awards and Honors
    University of Gdansk 199550th Anniversary Medal
    Society for Free Radical Biology & Medicine2006Lifetime Scientific Achievement Award
    Society for Free Radical Biology & Medicine2006Lifetime Scientific Achievement Award
    American College of Sports Medicine2007Presidential Award

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    Collapse Overview
    Kelvin J. A. Davies, Ph.D., D.Sc. is the James E. Birren Chair of Gerontology. Professor Davies was born and raised in London, England and is a dual citizen of Great Britain and the U.S.A. Educated at London University, Liverpool & Lancaster Universities, the University of Wisconsin, the University of California at Berkeley, and Harvard, he was previously a faculty member at Harvard University and Harvard Medical School. Before moving to USC’s Andrus Gerontology Center in 1996, Professor Davies was Chairman of the Department of Biochemistry & Molecular Biology at the Albany Medical College in New York, where he was also John A. Muntz University Professor and Distinguished Professor of Molecular Medicine.

    Deeply involved in research into oxidative stress and free radicals, Professor Davies is the (founding) Editor-in-Chief of the premier scientific journal in the field, Free Radical Biology & Medicine. Professor Davies is a Fellow of the Oxygen Society; a Fellow of the Society for Free Radical Biology & Medicine; a Fellow of the Gerontological Society of America; a Fellow of the American Association for the Advancement of Science; a Fellow of the Royal Institution (London); winner of the Harwood S. Belding award of the American Physiological Society; and holder of various medals, honorary degrees, and fellowships from several universities and scientific societies. Professor Davies is past President of the Society for Free Radical Biology & Medicine and the International Society for Free Radical Research. In 1996, he was named the National Parkinson Foundation Scholar. Recently he was awarded the Gold Medal of the European Society for Free Radical Research, and in 2012 Professor Davies was knighted as a Chevalier de l’Ordre National du Mérite de France (Knight, National Order of Merit of France) by the President of France.

    During aging, and in several age-related disease processes, vital cellular proteins, lipids, and DNA and RNA are damaged by free radicals produced by metabolism, chronic inflammation, radiation, smoke, pollution, and by many foods and drugs. These oxidized, non-functional, or dysfunctional cellular constituents must be removed or repaired before they cause further cell damage.

    Professor Davies’ research centers on the role of free radicals and oxidative stress in biology. In particular he is interested in genes that repair oxidatively damaged proteins, lipids, RNA, and DNA, and his laboratory has made major contributions to our understanding of this subject over the past twenty years. At the Andrus Gerontology Center, Professor Davies is focusing his research on the regulation of oxidative stress repair genes during aging. His laboratory is involved in biochemical, molecular biology, and genetic studies of both normal aging processes, and aging pathologies such as Alzheimer and Huntington diseases.
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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Sarcopenia - Molecular mechanisms and open questions. Ageing Res Rev. 2021 01; 65:101200. Wiedmer P, Jung T, Castro JP, Pomatto LCD, Sun PY, Davies KJA, Grune T. PMID: 33130247.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    2. The proteasome beta 5 subunit is essential for sexually divergent adaptive homeostatic responses to oxidative stress in D. melanogaster. Free Radic Biol Med. 2020 11 20; 160:67-77. Pomatto LCD, Sisliyan C, Wong S, Cline M, Tower J, Davies KJA. PMID: 32758664.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    3. Down regulation of glutathione and glutamate cysteine ligase in the inflammatory response of macrophages. Free Radic Biol Med. 2020 10; 158:53-59. Zhang H, Zhang SJ, Lyn N, Florentino A, Li A, Davies KJA, Forman HJ. PMID: 32682927.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Sex differences in the response to oxidative and proteolytic stress. Redox Biol. 2020 04; 31:101488. Tower J, Pomatto LCD, Davies KJA. PMID: 32201219.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    5. Silencing Bach1 alters aging-related changes in the expression of Nrf2-regulated genes in primary human bronchial epithelial cells. Arch Biochem Biophys. 2019 09 15; 672:108074. Zhang H, Zhou L, Davies KJA, Forman HJ. PMID: 31422075.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    6. Measuring redox effects on the activities of intracellular proteases such as the 20S Proteasome and the Immuno-Proteasome with fluorogenic peptides. Free Radic Biol Med. 2019 11 01; 143:16-24. Bonet-Costa V, Sun PY, Davies KJA. PMID: 31351175.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    7. Limitations to adaptive homeostasis in an hyperoxia-induced model of accelerated ageing. Redox Biol. 2019 06; 24:101194. Pomatto LCD, Sun PY, Yu K, Gullapalli S, Bwiza CP, Sisliyan C, Wong S, Zhang H, Forman HJ, Oliver PL, Davies KE, Davies KJA. PMID: 31022673.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    8. Sex-specific stress tolerance, proteolysis, and lifespan in the invertebrate Tigriopus californicus. Exp Gerontol. 2019 05; 119:146-156. Foley HB, Sun PY, Ramirez R, So BK, Venkataraman YR, Nixon EN, Davies KJA, Edmands S. PMID: 30738921.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    9. Free radicals and redox regulation in ageing. Free Radic Biol Med. 2019 04; 134:688-689. Davies KJA. PMID: 30710634.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    10. Does Bach1 & c-Myc dependent redox dysregulation of Nrf2 & adaptive homeostasis decrease cancer risk in ageing? Free Radic Biol Med. 2019 04; 134:708-714. Davies KJA, Forman HJ. PMID: 30695691.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    11. Adaptive homeostasis and the free radical theory of ageing. Free Radic Biol Med. 2018 08 20; 124:420-430. Pomatto LCD, Davies KJA. PMID: 29960100.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    12. Rust never sleeps: The continuing story of the Iron Bolt. Free Radic Biol Med. 2018 08 20; 124:353-357. van der Vliet A, Dick TP, Aust SD, Koppenol WH, Ursini F, Kettle AJ, Beckman JS, O'Donnell V, Darley-Usmar V, Lancaster J, Hogg N, Davies KJA, Forman HJ, Janssen-Heininger YMW. PMID: 29913216.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. The role of oxidative stress in anxiety disorder: cause or consequence? Free Radic Res. 2018 Jul; 52(7):737-750. Fedoce ADG, Ferreira F, Bota RG, Bonet-Costa V, Sun PY, Davies KJA. PMID: 29742940.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    14. To adapt or not to adapt: Consequences of declining Adaptive Homeostasis and Proteostasis with age. Mech Ageing Dev. 2019 01; 177:80-87. Pomatto LCD, Sun PY, Davies KJA. PMID: 29778759.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    15. Cardiovascular Adaptive Homeostasis in Exercise. Front Physiol. 2018; 9:369. Davies KJA. PMID: 29765327.
      View in: PubMed   Mentions:
    16. Aging attenuates redox adaptive homeostasis and proteostasis in female mice exposed to traffic-derived nanoparticles ('vehicular smog'). Free Radic Biol Med. 2018 06; 121:86-97. Pomatto LCD, Cline M, Woodward N, Pakbin P, Sioutas C, Morgan TE, Finch CE, Forman HJ, Davies KJA. PMID: 29709705.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    17. Sex-specific adaptive homeostasis in D. melanogaster depends on increased proteolysis by the 20S Proteasome: Data-in-Brief. Data Brief. 2018 Apr; 17:653-661. Pomatto LCD, Wong S, Tower J, Davies KJA. PMID: 29552615.
      View in: PubMed   Mentions:
    18. Sexual Dimorphism and Aging Differentially Regulate Adaptive Homeostasis. J Gerontol A Biol Sci Med Sci. 2018 01 16; 73(2):141-149. Pomatto LCD, Tower J, Davies KJA. PMID: 28525535.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    19. Redox Regulation of Homeostasis and Proteostasis in Peroxisomes. Physiol Rev. 2018 01 01; 98(1):89-115. Walker CL, Pomatto LCD, Tripathi DN, Davies KJA. PMID: 29167332.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    20. The Oxygen Paradox, the French Paradox, and age-related diseases. Geroscience. 2017 12; 39(5-6):499-550. Davies JMS, Cillard J, Friguet B, Cadenas E, Cadet J, Cayce R, Fishmann A, Liao D, Bulteau AL, Derbré F, Rébillard A, Burstein S, Hirsch E, Kloner RA, Jakowec M, Petzinger G, Sauce D, Sennlaub F, Limon I, Ursini F, Maiorino M, Economides C, Pike CJ, Cohen P, Salvayre AN, Halliday MR, Lundquist AJ, Jakowec NA, Mechta-Grigoriou F, Mericskay M, Mariani J, Li Z, Huang D, Grant E, Forman HJ, Finch CE, Sun PY, Pomatto LCD, Agbulut O, Warburton D, Neri C, Rouis M, Cillard P, Capeau J, Rosenbaum J, Davies KJA. PMID: 29270905.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    21. The role of declining adaptive homeostasis in ageing. J Physiol. 2017 12 15; 595(24):7275-7309. Pomatto LCD, Davies KJA. PMID: 29028112.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    22. Sexual dimorphism in oxidant-induced adaptive homeostasis in multiple wild-type D. melanogaster strains. Arch Biochem Biophys. 2017 12 15; 636:57-70. Pomatto LCD, Wong S, Tower J, Davies KJA. PMID: 29100984.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    23. Diminished stress resistance and defective adaptive homeostasis in age-related diseases. Clin Sci (Lond). 2017 Nov 01; 131(21):2573-2599. Lomeli N, Bota DA, Davies KJA. PMID: 29070521.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    24. Aging-related decline in the induction of Nrf2-regulated antioxidant genes in human bronchial epithelial cells. Redox Biol. 2018 04; 14:35-40. Zhou L, Zhang H, Davies KJA, Forman HJ. PMID: 28863281.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    25. SIRT1 may play a crucial role in overload-induced hypertrophy of skeletal muscle. J Physiol. 2017 06 01; 595(11):3361-3376. Koltai E, Bori Z, Chabert C, Dubouchaud H, Naito H, Machida S, Davies KJ, Murlasits Z, Fry AC, Boldogh I, Radak Z. PMID: 28251652.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    26. The age- and sex-specific decline of the 20s proteasome and the Nrf2/CncC signal transduction pathway in adaption and resistance to oxidative stress in Drosophila melanogaster. Aging (Albany NY). 2017 04; 9(4):1153-1185. Pomatto LCD, Wong S, Carney C, Shen B, Tower J, Davies KJA. PMID: 28373600.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    27. Oxidative DNA damage & repair: An introduction. Free Radic Biol Med. 2017 06; 107:2-12. Cadet J, Davies KJA. PMID: 28363603.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    28. Formation and repair of oxidatively generated damage in cellular DNA. Free Radic Biol Med. 2017 06; 107:13-34. Cadet J, Davies KJA, Medeiros MH, Di Mascio P, Wagner JR. PMID: 28057600.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    29. The Mitochondrial Lon Protease Is Required for Age-Specific and Sex-Specific Adaptation to Oxidative Stress. Curr Biol. 2017 Jan 09; 27(1):1-15. Pomatto LCD, Carney C, Shen B, Wong S, Halaszynski K, Salomon MP, Davies KJA, Tower J. PMID: 27916526.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    30. The Proteasome and Oxidative Stress in Alzheimer's Disease. Antioxid Redox Signal. 2016 12 01; 25(16):886-901. Bonet-Costa V, Pomatto LC, Davies KJ. PMID: 27392670.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    31. Corrigendum to "What is the concentration of hydrogen peroxide in blood and plasma?" [Arch. Biochem. Biophys. 603 (2016) 48-53]. Arch Biochem Biophys. 2016 Oct 01; 607:7. Forman HJ, Bernardo A, Davies KJ. PMID: 27552737.
      View in: PubMed   Mentions: 3     Fields:    
    32. The molecular chaperone Hsp70 promotes the proteolytic removal of oxidatively damaged proteins by the proteasome. Free Radic Biol Med. 2016 10; 99:153-166. Reeg S, Jung T, Castro JP, Davies KJA, Henze A, Grune T. PMID: 27498116.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    33. Mitochondrial Lon protease in human disease and aging: Including an etiologic classification of Lon-related diseases and disorders. Free Radic Biol Med. 2016 11; 100:188-198. Bota DA, Davies KJ. PMID: 27387767.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    34. Aging and SKN-1-dependent Loss of 20S Proteasome Adaptation to Oxidative Stress in C. elegans. J Gerontol A Biol Sci Med Sci. 2017 02; 72(2):143-151. Raynes R, Juarez C, Pomatto LC, Sieburth D, Davies KJ. PMID: 27341854.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    35. What is the concentration of hydrogen peroxide in blood and plasma? Arch Biochem Biophys. 2016 08 01; 603:48-53. Forman HJ, Bernardo A, Davies KJ. PMID: 27173735.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    36. Degradation of oxidized proteins by the proteasome: Distinguishing between the 20S, 26S, and immunoproteasome proteolytic pathways. Mol Aspects Med. 2016 08; 50:41-55. Raynes R, Pomatto LC, Davies KJ. PMID: 27155164.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    37. Adaptive homeostasis. Mol Aspects Med. 2016 06; 49:1-7. Davies KJ. PMID: 27112802.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimals
    38. The Immunoproteasome in oxidative stress, aging, and disease. Crit Rev Biochem Mol Biol. 2015 Jul-Aug; 51(4):268-81. Johnston-Carey HK, Pomatto LC, Davies KJ. PMID: 27098648.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    39. The Oxygen Paradox, oxidative stress, and ageing. Arch Biochem Biophys. 2016 Apr 01; 595:28-32. Davies KJ. PMID: 27095211.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    40. Transit of H2O2 across the endoplasmic reticulum membrane is not sluggish. Free Radic Biol Med. 2016 05; 94:157-60. Appenzeller-Herzog C, Bánhegyi G, Bogeski I, Davies KJ, Delaunay-Moisan A, Forman HJ, Görlach A, Kietzmann T, Laurindo F, Margittai E, Meyer AJ, Riemer J, Rützler M, Simmen T, Sitia R, Toledano MB, Touw IP. PMID: 26928585.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    41. The peroxisomal Lon protease LonP2 in aging and disease: functions and comparisons with mitochondrial Lon protease LonP1. Biol Rev Camb Philos Soc. 2017 May; 92(2):739-753. Pomatto LC, Raynes R, Davies KJ. PMID: 26852705.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    42. Commentary on "Bach1 differentially regulates distinct Nrf2-dependent genes in human venous and coronary artery endothelial cells adapted to physiological oxygen levels" by Chapple et al. Free Radic Biol Med. 2016 Mar; 92:163-164. Forman HJ, Davies KJA. PMID: 26802904.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    43. The calcineurin antagonist RCAN1-4 is induced by exhaustive exercise in rat skeletal muscle. Free Radic Biol Med. 2015 Oct; 87:290-9. Emrani R, Rébillard A, Lefeuvre L, Gratas-Delamarche A, Davies KJ, Cillard J. PMID: 26122706.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    44. Oxidative stress response and Nrf2 signaling in aging. Free Radic Biol Med. 2015 Nov; 88(Pt B):314-336. Zhang H, Davies KJA, Forman HJ. PMID: 26066302.
      View in: PubMed   Mentions: 178     Fields:    Translation:HumansAnimalsCells
    45. TGFβ1 rapidly activates Src through a non-canonical redox signaling mechanism. Arch Biochem Biophys. 2015 Feb 15; 568:1-7. Zhang H, Davies KJ, Forman HJ. PMID: 25585026.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    46. Acute Electrical Pulse Stimulation and Hyperglycemia Regulates RCAN1-4 in C2C12 myotubes through Oxidative Stress. Free Radic Biol Med. 2014 Oct; 75 Suppl 1:S29. Emrani Bidi R, Rebillard A, Saligaut D, Delamarche A, Davies KJ, Cillard J. PMID: 26461328.
      View in: PubMed   Mentions:    Fields:    
    47. What Goes Wrong with Lon in Ageing? Free Radic Biol Med. 2014 Oct; 75 Suppl 1:S6. Davies KJ. PMID: 26461412.
      View in: PubMed   Mentions: 1     Fields:    
    48. Even free radicals should follow some rules: a guide to free radical research terminology and methodology. Free Radic Biol Med. 2015 Jan; 78:233-5. Forman HJ, Augusto O, Brigelius-Flohe R, Dennery PA, Kalyanaraman B, Ischiropoulos H, Mann GE, Radi R, Roberts LJ, Vina J, Davies KJ. PMID: 25462642.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    49. Mitochondrial biogenesis-associated factors underlie the magnitude of response to aerobic endurance training in rats. Pflugers Arch. 2015 Apr; 467(4):779-88. Marton O, Koltai E, Takeda M, Koch LG, Britton SL, Davies KJ, Boldogh I, Radak Z. PMID: 24943897.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    50. Reactive oxygen and nitrogen species in neurodegeneration. Free Radic Biol Med. 2013 Sep; 62:1-3. Andersen JK, Davies KJA, Forman HJ. PMID: 23876468.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    51. How do nutritional antioxidants really work: nucleophilic tone and para-hormesis versus free radical scavenging in vivo. Free Radic Biol Med. 2014 Jan; 66:24-35. Forman HJ, Davies KJ, Ursini F. PMID: 23747930.
      View in: PubMed   Mentions: 146     Fields:    Translation:HumansAnimalsCells
    52. Resveratrol attenuates exercise-induced adaptive responses in rats selectively bred for low running performance. Dose Response. 2014 Jan; 12(1):57-71. Hart N, Sarga L, Csende Z, Koch LG, Britton SL, Davies KJ, Radak Z. PMID: 24659933.
      View in: PubMed   Mentions:
    53. Resveratrol enhances exercise training responses in rats selectively bred for high running performance. Food Chem Toxicol. 2013 Nov; 61:53-9. Hart N, Sarga L, Csende Z, Koltai E, Koch LG, Britton SL, Davies KJ, Kouretas D, Wessner B, Radak Z. PMID: 23422033.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    54. Upregulation of the mitochondrial Lon Protease allows adaptation to acute oxidative stress but dysregulation is associated with chronic stress, disease, and aging. Redox Biol. 2013 Feb 09; 1:258-64. Ngo JK, Pomatto LC, Davies KJ. PMID: 24024159.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    55. Chronic high levels of the RCAN1-1 protein may promote neurodegeneration and Alzheimer disease. Free Radic Biol Med. 2013 Sep; 62:47-51. Ermak G, Davies KJA. PMID: 23369757.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    56. Competition of nuclear factor-erythroid 2 factors related transcription factor isoforms, Nrf1 and Nrf2, in antioxidant enzyme induction. Redox Biol. 2013; 1:183-9. Chepelev NL, Zhang H, Liu H, McBride S, Seal AJ, Morgan TE, Finch CE, Willmore WG, Davies KJ, Forman HJ. PMID: 24024152.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    57. A conserved role for the 20S proteasome and Nrf2 transcription factor in oxidative stress adaptation in mammals, Caenorhabditis elegans and Drosophila melanogaster. J Exp Biol. 2013 Feb 15; 216(Pt 4):543-53. Pickering AM, Staab TA, Tower J, Sieburth D, Davies KJ. PMID: 23038734.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    58. Age-associated declines in mitochondrial biogenesis and protein quality control factors are minimized by exercise training. Am J Physiol Regul Integr Comp Physiol. 2012 Jul 15; 303(2):R127-34. Koltai E, Hart N, Taylor AW, Goto S, Ngo JK, Davies KJ, Radak Z. PMID: 22573103.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    59. Differential roles of proteasome and immunoproteasome regulators Pa28αβ, Pa28γ and Pa200 in the degradation of oxidized proteins. Arch Biochem Biophys. 2012 Jul 15; 523(2):181-90. Pickering AM, Davies KJ. PMID: 22564544.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    60. Nrf2-regulated phase II enzymes are induced by chronic ambient nanoparticle exposure in young mice with age-related impairments. Free Radic Biol Med. 2012 May 01; 52(9):2038-46. Zhang H, Liu H, Davies KJ, Sioutas C, Finch CE, Morgan TE, Forman HJ. PMID: 22401859.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    61. Chronic expression of RCAN1-1L protein induces mitochondrial autophagy and metabolic shift from oxidative phosphorylation to glycolysis in neuronal cells. J Biol Chem. 2012 Apr 20; 287(17):14088-98. Ermak G, Sojitra S, Yin F, Cadenas E, Cuervo AM, Davies KJ. PMID: 22389495.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    62. Cigarette smoke extract stimulates epithelial-mesenchymal transition through Src activation. Free Radic Biol Med. 2012 Apr 15; 52(8):1437-42. Zhang H, Liu H, Borok Z, Davies KJ, Ursini F, Forman HJ. PMID: 22342303.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    63. Nrf2-dependent induction of proteasome and Pa28αβ regulator are required for adaptation to oxidative stress. J Biol Chem. 2012 Mar 23; 287(13):10021-10031. Pickering AM, Linder RA, Zhang H, Forman HJ, Davies KJA. PMID: 22308036.
      View in: PubMed   Mentions: 100     Fields:    Translation:AnimalsCells
    64. Degradation of damaged proteins: the main function of the 20S proteasome. Prog Mol Biol Transl Sci. 2012; 109:227-48. Pickering AM, Davies KJ. PMID: 22727423.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    65. Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations. Free Radic Biol Med. 2012 Jan 01; 52(1):1-6. Kalyanaraman B, Darley-Usmar V, Davies KJ, Dennery PA, Forman HJ, Grisham MB, Mann GE, Moore K, Roberts LJ, Ischiropoulos H. PMID: 22027063.
      View in: PubMed   Mentions: 452     Fields:    Translation:Cells
    66. A simple fluorescence labeling method for studies of protein oxidation, protein modification, and proteolysis. Free Radic Biol Med. 2012 Jan 15; 52(2):239-46. Pickering AM, Davies KJ. PMID: 21988844.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    67. Impairment of lon-induced protection against the accumulation of oxidized proteins in senescent wi-38 fibroblasts. J Gerontol A Biol Sci Med Sci. 2011 Nov; 66(11):1178-85. Ngo JK, Pomatto LC, Bota DA, Koop AL, Davies KJ. PMID: 21868393.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    68. HSP70 mediates dissociation and reassociation of the 26S proteasome during adaptation to oxidative stress. Free Radic Biol Med. 2011 Oct 01; 51(7):1355-64. Grune T, Catalgol B, Licht A, Ermak G, Pickering AM, Ngo JK, Davies KJ. PMID: 21767633.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansCells
    69. Do RCAN1 proteins link chronic stress with neurodegeneration? FASEB J. 2011 Oct; 25(10):3306-11. Ermak G, Pritchard MA, Dronjak S, Niu B, Davies KJ. PMID: 21680892.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    70. RasGrf1 and aging. Aging (Albany NY). 2011 May; 3(5):455. Davies KJ, Forman HJ. PMID: 21666282.
      View in: PubMed   Mentions: 2     Fields:    
    71. Amyloid-β toxicity and tau hyperphosphorylation are linked via RCAN1 in Alzheimer's disease. J Alzheimers Dis. 2011; 27(4):701-9. Lloret A, Badia MC, Giraldo E, Ermak G, Alonso MD, Pallardó FV, Davies KJ, Viña J. PMID: 21876249.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    72. The immunoproteasome, the 20S proteasome and the PA28αβ proteasome regulator are oxidative-stress-adaptive proteolytic complexes. Biochem J. 2010 Dec 15; 432(3):585-94. Pickering AM, Koop AL, Teoh CY, Ermak G, Grune T, Davies KJ. PMID: 20919990.
      View in: PubMed   Mentions: 122     Fields:    Translation:HumansAnimalsCells
    73. The evolution of Free Radical Biology & Medicine: still radical after a quarter of a century! Free Radic Biol Med. 2010 Dec 15; 49(12):1825-33. Davies KJ. PMID: 21146787.
      View in: PubMed   Mentions: 1     Fields:    
    74. Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli. EMBO Mol Med. 2010 Dec; 2(12):490-503. Costa V, Giacomello M, Hudec R, Lopreiato R, Ermak G, Lim D, Malorni W, Davies KJ, Carafoli E, Scorrano L. PMID: 21069748.
      View in: PubMed   Mentions: 98     Fields:    Translation:HumansAnimalsCells
    75. Protein oxidative modifications in the ageing brain: consequence for the onset of neurodegenerative disease. Free Radic Res. 2011 Jan; 45(1):73-88. Grimm S, Hoehn A, Davies KJ, Grune T. PMID: 20815785.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    76. Tau protein degradation is catalyzed by the ATP/ubiquitin-independent 20S proteasome under normal cell conditions. Arch Biochem Biophys. 2010 Aug 15; 500(2):181-8. Grune T, Botzen D, Engels M, Voss P, Kaiser B, Jung T, Grimm S, Ermak G, Davies KJ. PMID: 20478262.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    77. Regulator of calcineurin (RCAN1-1L) is deficient in Huntington disease and protective against mutant huntingtin toxicity in vitro. J Biol Chem. 2009 May 01; 284(18):11845-53. Ermak G, Hench KJ, Chang KT, Sachdev S, Davies KJ. PMID: 19270310.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    78. Mitochondrial Lon protease is a human stress protein. Free Radic Biol Med. 2009 Apr 15; 46(8):1042-8. Ngo JK, Davies KJ. PMID: 19439239.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    79. Exercise improves import of 8-oxoguanine DNA glycosylase into the mitochondrial matrix of skeletal muscle and enhances the relative activity. Free Radic Biol Med. 2009 Jan 15; 46(2):238-43. Radak Z, Atalay M, Jakus J, Boldogh I, Davies K, Goto S. PMID: 18992806.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    80. Decreased SIRT1 deacetylase activity in sporadic inclusion-body myositis muscle fibers. Neurobiol Aging. 2010 Sep; 31(9):1637-48. Nogalska A, D'Agostino C, Engel WK, Davies KJ, Askanas V. PMID: 18922603.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    81. Importance of the lon protease in mitochondrial maintenance and the significance of declining lon in aging. Ann N Y Acad Sci. 2007 Nov; 1119:78-87. Ngo JK, Davies KJ. PMID: 18056957.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    82. Production, detection, and adaptive responses to free radicals in exercise. Free Radic Biol Med. 2008 Jan 15; 44(2):215-23. Sachdev S, Davies KJ. PMID: 18191757.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    83. Is vitamin E an antioxidant, a regulator of signal transduction and gene expression, or a 'junk' food? Comments on the two accompanying papers: "Molecular mechanism of alpha-tocopherol action" by A. Azzi and "Vitamin E, antioxidant and nothing more" by M. Traber and J. Atkinson. Free Radic Biol Med. 2007 Jul 01; 43(1):2-3. Brigelius-Flohé R, Davies KJ. PMID: 17561087.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    84. Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin. FASEB J. 2007 Oct; 21(12):3023-8. Davies KJ, Ermak G, Rothermel BA, Pritchard M, Heitman J, Ahnn J, Henrique-Silva F, Crawford D, Canaider S, Strippoli P, Carinci P, Min KT, Fox DS, Cunningham KW, Bassel-Duby R, Olson EN, Zhang Z, Williams RS, Gerber HP, Pérez-Riba M, Seo H, Cao X, Klee CB, Redondo JM, Maltais LJ, Bruford EA, Povey S, Molkentin JD, McKeon FD, Duh EJ, Crabtree GR, Cyert MS, de la Luna S, Estivill X. PMID: 17595344.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimals
    85. Free radicals and exercise: an introduction. Free Radic Biol Med. 2008 Jan 15; 44(2):123-5. Packer L, Cadenas E, Davies KJ. PMID: 18191747.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    86. RCAN1-1L is overexpressed in neurons of Alzheimer's disease patients. FEBS J. 2007 Apr; 274(7):1715-24. Harris CD, Ermak G, Davies KJ. PMID: 17331188.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    87. Phosphorylation inhibits turnover of the tau protein by the proteasome: influence of RCAN1 and oxidative stress. Biochem J. 2006 Dec 15; 400(3):511-20. Poppek D, Keck S, Ermak G, Jung T, Stolzing A, Ullrich O, Davies KJ, Grune T. PMID: 16939415.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    88. Optimal determination of heart tissue 26S-proteasome activity requires maximal stimulating ATP concentrations. J Mol Cell Cardiol. 2007 Jan; 42(1):265-9. Powell SR, Davies KJ, Divald A. PMID: 17140599.
      View in: PubMed   Mentions: 42     Fields:    Translation:Animals
    89. RCAN1 (DSCR1 or Adapt78) stimulates expression of GSK-3beta. FEBS J. 2006 May; 273(10):2100-9. Ermak G, Harris CD, Battocchio D, Davies KJ. PMID: 16649988.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    90. Free radical biology and medicine: it's a gas, man! . 2006 Sep; 291(3):R491-511. Pryor WA, Houk KN, Foote CS, Fukuto JM, Ignarro LJ, Squadrito GL, Davies KJ. PMID: 16627692.
      View in: PubMed   Mentions:
    91. Preferential degradation of oxidized proteins by the 20S proteasome may be inhibited in aging and in inflammatory neuromuscular diseases. Neurology. 2006 Jan 24; 66(2 Suppl 1):S93-6. Davies KJ, Shringarpure R. PMID: 16432154.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    92. Protein oxidation and degradation during postmitotic senescence. Free Radic Biol Med. 2005 Nov 01; 39(9):1208-15. Grune T, Merker K, Jung T, Sitte N, Davies KJ. PMID: 16214036.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    93. Multiple roles of the DSCR1 (Adapt78 or RCAN1) gene and its protein product calcipressin 1 (or RCAN1) in disease. Cell Mol Life Sci. 2005 Nov; 62(21):2477-86. Harris CD, Ermak G, Davies KJ. PMID: 16231093.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    94. The evolution of Free Radical Biology & Medicine: a 20-year history. Free Radic Biol Med. 2005 Nov 15; 39(10):1263-4. Davies KJ, Pryor WA. PMID: 16257637.
      View in: PubMed   Mentions: 4     Fields:    
    95. Proteasome inhibition and aggresome formation in sporadic inclusion-body myositis and in amyloid-beta precursor protein-overexpressing cultured human muscle fibers. Am J Pathol. 2005 Aug; 167(2):517-26. Fratta P, Engel WK, McFerrin J, Davies KJ, Lin SW, Askanas V. PMID: 16049336.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    96. Oxidized and ubiquitinated proteins may predict recovery of postischemic cardiac function: essential role of the proteasome. Antioxid Redox Signal. 2005 May-Jun; 7(5-6):538-46. Powell SR, Wang P, Katzeff H, Shringarpure R, Teoh C, Khaliulin I, Das DK, Davies KJ, Schwalb H. PMID: 15889999.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    97. Aggregates of oxidized proteins (lipofuscin) induce apoptosis through proteasome inhibition and dysregulation of proapoptotic proteins. Free Radic Biol Med. 2005 Apr 15; 38(8):1093-101. Powell SR, Wang P, Divald A, Teichberg S, Haridas V, McCloskey TW, Davies KJ, Katzeff H. PMID: 15780767.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    98. Downregulation of the human Lon protease impairs mitochondrial structure and function and causes cell death. Free Radic Biol Med. 2005 Mar 01; 38(5):665-77. Bota DA, Ngo JK, Davies KJ. PMID: 15683722.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCells
    99. Decreased proteolysis caused by protein aggregates, inclusion bodies, plaques, lipofuscin, ceroid, and 'aggresomes' during oxidative stress, aging, and disease. Int J Biochem Cell Biol. 2004 Dec; 36(12):2519-30. Grune T, Jung T, Merker K, Davies KJ. PMID: 15325589.
      View in: PubMed   Mentions: 160     Fields:    Translation:HumansAnimalsCells
    100. Potential roles of protein oxidation and the immunoproteasome in MHC class I antigen presentation: the 'PrOxI' hypothesis. Arch Biochem Biophys. 2004 Mar 01; 423(1):88-96. Teoh CY, Davies KJ. PMID: 14871471.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    101. Free radical biology - terminology and critical thinking. FEBS Lett. 2004 Jan 30; 558(1-3):3-6. Azzi A, Davies KJ, Kelly F. PMID: 14982062.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    102. DSCR1(Adapt78) modulates expression of SOD1. FASEB J. 2004 Jan; 18(1):62-9. Ermak G, Cheadle C, Becker KG, Harris CD, Davies KJ. PMID: 14718387.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    103. Genetic aberrations in Chernobyl-related thyroid cancers: implications for possible future nuclear accidents or nuclear attacks. IUBMB Life. 2003 Dec; 55(12):637-41. Ermak G, Figge JJ, Kartel NA, Davies KJ. PMID: 14768999.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansPHPublic Health
    104. The proteasomal system and HNE-modified proteins. Mol Aspects Med. 2003 Aug-Oct; 24(4-5):195-204. Grune T, Davies KJ. PMID: 12892997.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    105. Tyrosine oxidation products: analysis and biological relevance. Amino Acids. 2003 Dec; 25(3-4):227-32. Giulivi C, Traaseth NJ, Davies KJ. PMID: 14661086.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    106. Cytotoxic effect of doxycycline and its implications for tet-on gene expression systems. Anal Biochem. 2003 Jul 01; 318(1):152-4. Ermak G, Cancasci VJ, Davies KJ. PMID: 12782044.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    107. Selective degradation of oxidatively modified protein substrates by the proteasome. Biochem Biophys Res Commun. 2003 Jun 06; 305(3):709-18. Grune T, Merker K, Sandig G, Davies KJ. PMID: 12763051.
      View in: PubMed   Mentions: 124     Fields:    Translation:AnimalsCells
    108. Proteasome inhibitors induce intracellular protein aggregation and cell death by an oxygen-dependent mechanism. FEBS Lett. 2003 May 08; 542(1-3):89-94. Demasi M, Davies KJ. PMID: 12729904.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    109. DSCR1(Adapt78)--a Janus gene providing stress protection but causing Alzheimer's disease? IUBMB Life. 2003 Jan; 55(1):29-31. Ermak G, Davies KJ. PMID: 12716059.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    110. Characterization of adapt33, a stress-inducible riboregulator. Gene Expr. 2003; 11(2):85-94. Wang Y, Davies KJ, Melendez JA, Crawford DR. PMID: 12837039.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    111. Modulation of Lon protease activity and aconitase turnover during aging and oxidative stress. FEBS Lett. 2002 Dec 04; 532(1-2):103-6. Bota DA, Van Remmen H, Davies KJ. PMID: 12459471.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    112. Ubiquitin conjugation is not required for the degradation of oxidized proteins by proteasome. J Biol Chem. 2003 Jan 03; 278(1):311-8. Shringarpure R, Grune T, Mehlhase J, Davies KJ. PMID: 12401807.
      View in: PubMed   Mentions: 124     Fields:    Translation:AnimalsCells
    113. Ezrin turnover and cell shape changes catalyzed by proteasome in oxidatively stressed cells. FASEB J. 2002 Oct; 16(12):1602-10. Grune T, Reinheckel T, North JA, Li R, Bescos PB, Shringarpure R, Davies KJ. PMID: 12374783.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    114. Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism. Nat Cell Biol. 2002 Sep; 4(9):674-80. Bota DA, Davies KJ. PMID: 12198491.
      View in: PubMed   Mentions: 182     Fields:    Translation:HumansAnimalsCells
    115. Atherosclerosis: another protein misfolding disease? Trends Mol Med. 2002 Aug; 8(8):370-4. Ursini F, Davies KJ, Maiorino M, Parasassi T, Sevanian A. PMID: 12127722.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    116. Gene expression in Alzheimer's disease. Drugs Today (Barc). 2002 Jul; 38(7):509-16. Ermak G, Davies KJ. PMID: 12582468.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    117. The DSCR1 (Adapt78) isoform 1 protein calcipressin 1 inhibits calcineurin and protects against acute calcium-mediated stress damage, including transient oxidative stress. FASEB J. 2002 Jun; 16(8):814-24. Ermak G, Harris CD, Davies KJ. PMID: 12039863.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    118. Protein turnover by the proteasome in aging and disease. Free Radic Biol Med. 2002 Jun 01; 32(11):1084-9. Shringarpure R, Davies KJ. PMID: 12031893.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    119. Calcium and oxidative stress: from cell signaling to cell death. Mol Immunol. 2002 Feb; 38(10):713-21. Ermak G, Davies KJ. PMID: 11841831.
      View in: PubMed   Mentions: 177     Fields:    Translation:HumansAnimalsCells
    120. Proteasome-dependent turnover of protein disulfide isomerase in oxidatively stressed cells. Arch Biochem Biophys. 2002 Jan 15; 397(2):407-13. Grune T, Reinheckel T, Li R, North JA, Davies KJ. PMID: 11795901.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    121. Differential display: a critical analysis. Gene Expr. 2002; 10(3):101-7. Crawford DR, Kochheiser JC, Schools GP, Salmon SL, Davies KJ. PMID: 12064572.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    122. Analysis of gene expression following oxidative stress. Methods Mol Biol. 2002; 196:155-62. Crawford DR, Suzuki T, Sesay J, Davies KJ. PMID: 12152194.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    123. Protein oxidation and 20S proteasome-dependent proteolysis in mammalian cells. Cell Mol Life Sci. 2001 Sep; 58(10):1442-50. Shringarpure R, Grune T, Davies KJ. PMID: 11693525.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimals
    124. Chronic overexpression of the calcineurin inhibitory gene DSCR1 (Adapt78) is associated with Alzheimer's disease. J Biol Chem. 2001 Oct 19; 276(42):38787-94. Ermak G, Morgan TE, Davies KJ. PMID: 11483593.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimalsCells
    125. Protein degradation in mitochondria: implications for oxidative stress, aging and disease: a novel etiological classification of mitochondrial proteolytic disorders. Mitochondrion. 2001 Jun; 1(1):33-49. Bota DA, Davies KJ. PMID: 16120267.
      View in: PubMed   Mentions: 27     Fields:    
    126. Glutathiolation of the proteasome is enhanced by proteolytic inhibitors. Arch Biochem Biophys. 2001 May 15; 389(2):254-63. Demasi M, Shringarpure R, Davies KJ. PMID: 11339815.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    127. Degradation of oxidized proteins by the 20S proteasome. Biochimie. 2001 Mar-Apr; 83(3-4):301-10. Davies KJ. PMID: 11295490.
      View in: PubMed   Mentions: 239     Fields:    Translation:HumansAnimalsCells
    128. The essential role of calcium in induction of the DSCR1 (ADAPT78) gene. Biofactors. 2001; 15(2-4):91-3. Davies KJ, Harris CD, Ermak G. PMID: 12016333.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    129. Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part I--effects of proliferative senescence. FASEB J. 2000 Dec; 14(15):2495-502. Sitte N, Merker K, Von Zglinicki T, Grune T, Davies KJ. PMID: 11099467.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    130. Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part II--aging of nondividing cells. FASEB J. 2000 Dec; 14(15):2503-10. Sitte N, Merker K, Von Zglinicki T, Davies KJ, Grune T. PMID: 11099468.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    131. 4-Hydroxynonenal-modified amyloid-beta peptide inhibits the proteasome: possible importance in Alzheimer's disease. Cell Mol Life Sci. 2000 Nov; 57(12):1802-9. Shringarpure R, Grune T, Sitte N, Davies KJ. PMID: 11130184.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    132. Oxidative stress, antioxidant defenses, and damage removal, repair, and replacement systems. IUBMB Life. 2000 Oct-Nov; 50(4-5):279-89. Davies KJ. PMID: 11327322.
      View in: PubMed   Mentions: 148     Fields:    Translation:HumansAnimalsCells
    133. An overview of oxidative stress. IUBMB Life. 2000 Oct-Nov; 50(4-5):241-4. Davies KJ. PMID: 11327316.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    134. Proteasome inhibition by lipofuscin/ceroid during postmitotic aging of fibroblasts. FASEB J. 2000 Aug; 14(11):1490-8. Sitte N, Huber M, Grune T, Ladhoff A, Doecke WD, Von Zglinicki T, Davies KJ. PMID: 10928983.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCells
    135. Mitochondrial free radical generation, oxidative stress, and aging. Free Radic Biol Med. 2000 Aug; 29(3-4):222-30. Cadenas E, Davies KJ. PMID: 11035250.
      View in: PubMed   Mentions: 643     Fields:    Translation:AnimalsCells
    136. Polynucleotide degradation during early stage response to oxidative stress is specific to mitochondria. Free Radic Biol Med. 2000 Jan 15; 28(2):281-8. Abramova NE, Davies KJ, Crawford DR. PMID: 11281296.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    137. The measurement of protein degradation in response to oxidative stress. Methods Mol Biol. 2000; 99:49-60. Reinheckel T, Grune T, Davies KJ. PMID: 10909076.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    138. adapt78, a stress-inducible mRNA, is related to the glucose-regulated protein family of genes. Arch Biochem Biophys. 1999 Aug 01; 368(1):67-74. Leahy KP, Davies KJ, Dull M, Kort JJ, Lawrence KW, Crawford DR. PMID: 10415113.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    139. The broad spectrum of responses to oxidants in proliferating cells: a new paradigm for oxidative stress. IUBMB Life. 1999 Jul; 48(1):41-7. Davies KJ. PMID: 10791914.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimals
    140. Poly-ADP ribose polymerase activates nuclear proteasome to degrade oxidatively damaged histones. Proc Natl Acad Sci U S A. 1999 May 25; 96(11):6223-8. Ullrich O, Reinheckel T, Sitte N, Hass R, Grune T, Davies KJ. PMID: 10339569.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCells
    141. Influence of DNA binding on the degradation of oxidized histones by the 20S proteasome. Arch Biochem Biophys. 1999 Feb 15; 362(2):211-6. Ullrich O, Sitte N, Sommerburg O, Sandig V, Davies KJ, Grune T. PMID: 9989929.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    142. Oxidative stress causes a general, calcium-dependent degradation of mitochondrial polynucleotides. Free Radic Biol Med. 1998 Dec; 25(9):1106-11. Crawford DR, Abramova NE, Davies KJ. PMID: 9870565.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    143. Comparative resistance of the 20S and 26S proteasome to oxidative stress. Biochem J. 1998 Nov 01; 335 ( Pt 3):637-42. Reinheckel T, Sitte N, Ullrich O, Kuckelkorn U, Davies KJ, Grune T. PMID: 9794805.
      View in: PubMed   Mentions: 115     Fields:    Translation:HumansCells
    144. Peroxynitrite increases the degradation of aconitase and other cellular proteins by proteasome. J Biol Chem. 1998 May 01; 273(18):10857-62. Grune T, Blasig IE, Sitte N, Roloff B, Haseloff R, Davies KJ. PMID: 9556559.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    145. Degradation of oxidized proteins in mammalian cells. FASEB J. 1997 Jun; 11(7):526-34. Grune T, Reinheckel T, Davies KJ. PMID: 9212076.
      View in: PubMed   Mentions: 150     Fields:    Translation:HumansAnimalsCells
    146. Hamster adapt78 mRNA is a Down syndrome critical region homologue that is inducible by oxidative stress. Arch Biochem Biophys. 1997 Jun 01; 342(1):6-12. Crawford DR, Leahy KP, Abramova N, Lan L, Wang Y, Davies KJ. PMID: 9185608.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    147. Modulation of a cardiogenic shock inducible RNA by chemical stress: adapt73/PigHep3. Surgery. 1997 May; 121(5):581-7. Crawford DR, Davies KJ. PMID: 9142159.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    148. Breakdown of oxidized proteins as a part of secondary antioxidant defenses in mammalian cells. Biofactors. 1997; 6(2):165-72. Grune T, Davies KJ. PMID: 9259998.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    149. Down-regulation of mammalian mitochondrial RNAs during oxidative stress. Free Radic Biol Med. 1997; 22(3):551-9. Crawford DR, Wang Y, Schools GP, Kochheiser J, Davies KJ. PMID: 8981048.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    150. 16S mitochondrial ribosomal RNA degradation is associated with apoptosis. Free Radic Biol Med. 1997; 22(7):1295-300. Crawford DR, Lauzon RJ, Wang Y, Mazurkiewicz JE, Schools GP, Davies KJ. PMID: 9098105.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    151. adapt33, a novel oxidant-inducible RNA from hamster HA-1 cells. Arch Biochem Biophys. 1996 Aug 15; 332(2):255-60. Wang Y, Crawford DR, Davies KJ. PMID: 8806733.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    152. Degradation of oxidized proteins in K562 human hematopoietic cells by proteasome. J Biol Chem. 1996 Jun 28; 271(26):15504-9. Grune T, Reinheckel T, Davies KJ. PMID: 8663134.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansCells
    153. Oxidant-inducible adapt 15 RNA is associated with growth arrest- and DNA damage-inducible gadd153 and gadd45. Arch Biochem Biophys. 1996 May 15; 329(2):137-44. Crawford DR, Schools GP, Davies KJ. PMID: 8638945.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    154. Hydrogen peroxide induces the expression of adapt15, a novel RNA associated with polysomes in hamster HA-1 cells. Arch Biochem Biophys. 1996 Jan 15; 325(2):256-64. Crawford DR, Schools GP, Salmon SL, Davies KJ. PMID: 8561505.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    155. Oxidative stress induces the levels of a MafG homolog in hamster HA-1 cells. Free Radic Biol Med. 1996; 21(4):521-5. Crawford DR, Leahy KP, Wang Y, Schools GP, Kochheiser JC, Davies KJ. PMID: 8886803.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    156. Transient adaptation of oxidative stress in mammalian cells. Arch Biochem Biophys. 1995 Apr 01; 318(1):231-40. Wiese AG, Pacifici RE, Davies KJ. PMID: 7726566.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    157. Transient adaptation to oxidative stress in yeast. Arch Biochem Biophys. 1995 Feb 20; 317(1):1-6. Davies JM, Lowry CV, Davies KJ. PMID: 7872770.
      View in: PubMed   Mentions: 38     Fields:    Translation:Animals
    158. Proteolysis in cultured liver epithelial cells during oxidative stress. Role of the multicatalytic proteinase complex, proteasome. J Biol Chem. 1995 Feb 03; 270(5):2344-51. Grune T, Reinheckel T, Joshi M, Davies KJ. PMID: 7836468.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    159. Oxidative stress: the paradox of aerobic life. Biochem Soc Symp. 1995; 61:1-31. Davies KJ. PMID: 8660387.
      View in: PubMed   Mentions: 186     Fields:    Translation:Humans
    160. Adaptive response and oxidative stress. Environ Health Perspect. 1994 Dec; 102 Suppl 10:25-8. Crawford DR, Davies KJ. PMID: 7705299.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    161. Exposure of hydrophobic moieties promotes the selective degradation of hydrogen peroxide-modified hemoglobin by the multicatalytic proteinase complex, proteasome. Arch Biochem Biophys. 1994 Jun; 311(2):329-41. Giulivi C, Pacifici RE, Davies KJ. PMID: 8203895.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    162. Hydrogen peroxide production by red blood cells. Free Radic Biol Med. 1994 Jan; 16(1):123-9. Giulivi C, Hochstein P, Davies KJ. PMID: 8299988.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    163. Hydrogen peroxide-mediated ferrylhemoglobin generation in vitro and in red blood cells. Methods Enzymol. 1994; 231:490-6. Giulivi C, Davies KJ. PMID: 8041270.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    164. Dityrosine: a marker for oxidatively modified proteins and selective proteolysis. Methods Enzymol. 1994; 233:363-71. Giulivi C, Davies KJ. PMID: 8015471.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    165. Assessing gene expression during oxidative stress. Methods Enzymol. 1994; 234:175-217. Crawford DR, Edbauer-Nechamen CA, Lowry CV, Salmon SL, Kim YK, Davies JM, Davies KJ. PMID: 7528871.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    166. Potential roles of hypochlorous acid and N-chloroamines in collagen breakdown by phagocytic cells in synovitis. Free Radic Biol Med. 1993 Dec; 15(6):637-43. Davies JM, Horwitz DA, Davies KJ. PMID: 8138190.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    167. Hydrophobicity as the signal for selective degradation of hydroxyl radical-modified hemoglobin by the multicatalytic proteinase complex, proteasome. J Biol Chem. 1993 Jul 25; 268(21):15405-11. Pacifici RE, Kono Y, Davies KJ. PMID: 8393440.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    168. Protein modification by oxidants and the role of proteolytic enzymes. Biochem Soc Trans. 1993 May; 21(2):346-53. Davies KJ. PMID: 8359494.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    169. Dityrosine and tyrosine oxidation products are endogenous markers for the selective proteolysis of oxidatively modified red blood cell hemoglobin by (the 19 S) proteasome. J Biol Chem. 1993 Apr 25; 268(12):8752-9. Giulivi C, Davies KJ. PMID: 8473319.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    170. Serum urate as an antioxidant for ascorbic acid. Am J Clin Nutr. 1991 12; 54(6 Suppl):1129S-1134S. Sevanian A, Davies KJ, Hochstein P. PMID: 1962559.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    171. Phospholipid hydroperoxide glutathione peroxidase is the 18-kDa selenoprotein expressed in human tumor cell lines. J Biol Chem. 1991 Apr 25; 266(12):7728-32. Maiorino M, Chu FF, Ursini F, Davies KJ, Doroshow JH, Esworthy RS. PMID: 2019596.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    172. Protein, lipid and DNA repair systems in oxidative stress: the free-radical theory of aging revisited. Gerontology. 1991; 37(1-3):166-80. Pacifici RE, Davies KJ. PMID: 2055497.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    173. HSP70 and other possible heat shock or oxidative stress proteins are induced in skeletal muscle, heart, and liver during exercise. Free Radic Biol Med. 1991; 11(3):239-46. Salo DC, Donovan CM, Davies KJ. PMID: 1937141.
      View in: PubMed   Mentions: 66     Fields:    Translation:Animals
    174. A novel antioxidant role for hemoglobin. The comproportionation of ferrylhemoglobin with oxyhemoglobin. J Biol Chem. 1990 Nov 15; 265(32):19453-60. Giulivi C, Davies KJ. PMID: 2174037.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    175. The oxidative inactivation of mitochondrial electron transport chain components and ATPase. J Biol Chem. 1990 Sep 25; 265(27):16330-6. Zhang Y, Marcillat O, Giulivi C, Ernster L, Davies KJ. PMID: 2168888.
      View in: PubMed   Mentions: 146     Fields:    Translation:AnimalsCells
    176. Superoxide dismutase undergoes proteolysis and fragmentation following oxidative modification and inactivation. J Biol Chem. 1990 Jul 15; 265(20):11919-27. Salo DC, Pacifici RE, Lin SW, Giulivi C, Davies KJ. PMID: 2195028.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    177. Protein oxidation and proteolytic degradation. General aspects and relationship to cataract formation. Adv Exp Med Biol. 1990; 264:503-11. Davies KJ. PMID: 2244532.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    178. Protein degradation as an index of oxidative stress. Methods Enzymol. 1990; 186:485-502. Pacifici RE, Davies KJ. PMID: 2233315.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    179. Lens proteasome shows enhanced rates of degradation of hydroxyl radical modified alpha-crystallin. Free Radic Biol Med. 1990; 8(3):217-22. Murakami K, Jahngen JH, Lin SW, Davies KJ, Taylor A. PMID: 2341052.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    180. Oxidative and non-oxidative mechanisms in the inactivation of cardiac mitochondrial electron transport chain components by doxorubicin. Biochem J. 1989 Apr 01; 259(1):181-9. Marcillat O, Zhang Y, Davies KJ. PMID: 2719642.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    181. Macroxyproteinase (M.O.P.): a 670 kDa proteinase complex that degrades oxidatively denatured proteins in red blood cells. Free Radic Biol Med. 1989; 7(5):521-36. Pacifici RE, Salo DC, Davies KJ. PMID: 2558981.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    182. The inhibition of bacterial growth by hypochlorous acid. Possible role in the bactericidal activity of phagocytes. Biochem J. 1988 Sep 15; 254(3):685-92. McKenna SM, Davies KJ. PMID: 2848494.
      View in: PubMed   Mentions: 37     Fields:    Translation:Cells
    183. Mitochondria contain a proteolytic system which can recognize and degrade oxidatively-denatured proteins. Biochem J. 1988 Sep 15; 254(3):677-83. Marcillat O, Zhang Y, Lin SW, Davies KJ. PMID: 3196285.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    184. The measurement of protein degradation in response to oxidative stress. Basic Life Sci. 1988; 49:531-5. Pacifici RE, Lin SW, Davies KJ. PMID: 3074786.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    185. A secondary antioxidant defense role for proteolytic systems. Basic Life Sci. 1988; 49:575-85. Davies KJ. PMID: 3074788.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    186. Oxidatively denatured proteins are degraded by an ATP-independent proteolytic pathway in Escherichia coli. Free Radic Biol Med. 1988; 5(4):225-36. Davies KJ, Lin SW. PMID: 3075950.
      View in: PubMed   Mentions: 14     Fields:    Translation:Cells
    187. Bacterial killing by phagocytes: potential role(s) of hypochlorous acid and hydrogen peroxide in protein turnover, DNA synthesis, and RNA synthesis. Basic Life Sci. 1988; 49:829-32. McKenna SM, Davies KJ. PMID: 2471506.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    188. Superoxide dismutase is preferentially degraded by a proteolytic system from red blood cells following oxidative modification by hydrogen peroxide. Free Radic Biol Med. 1988; 5(5-6):335-9. Salo DC, Lin SW, Pacifici RE, Davies KJ. PMID: 2476367.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    189. Degradation of oxidatively denatured proteins in Escherichia coli. Free Radic Biol Med. 1988; 5(4):215-23. Davies KJ, Lin SW. PMID: 2908182.
      View in: PubMed   Mentions: 24     Fields:    Translation:Cells
    190. Protein damage and degradation by oxygen radicals. II. Modification of amino acids. J Biol Chem. 1987 Jul 15; 262(20):9902-7. Davies KJ, Delsignore ME, Lin SW. PMID: 3036876.
      View in: PubMed   Mentions: 98     Fields:    
    191. Protein damage and degradation by oxygen radicals. IV. Degradation of denatured protein. J Biol Chem. 1987 Jul 15; 262(20):9914-20. Davies KJ, Lin SW, Pacifici RE. PMID: 3036878.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    192. Redox cycling of anthracyclines by cardiac mitochondria. I. Anthracycline radical formation by NADH dehydrogenase. J Biol Chem. 1986 Mar 05; 261(7):3060-7. Davies KJ, Doroshow JH. PMID: 3456345.
      View in: PubMed   Mentions: 118     Fields:    Translation:AnimalsCells
    193. Redox cycling of anthracyclines by cardiac mitochondria. II. Formation of superoxide anion, hydrogen peroxide, and hydroxyl radical. J Biol Chem. 1986 Mar 05; 261(7):3068-74. Doroshow JH, Davies KJ. PMID: 3005279.
      View in: PubMed   Mentions: 90     Fields:    Translation:AnimalsCells
    194. Intracellular proteolytic systems may function as secondary antioxidant defenses: an hypothesis. J Free Radic Biol Med. 1986; 2(3):155-73. Davies KJ. PMID: 3553299.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    195. Distinguishing effects of anemia and muscle iron deficiency on exercise bioenergetics in the rat. Am J Physiol. 1984 Jun; 246(6 Pt 1):E535-43. Davies KJ, Donovan CM, Refino CJ, Brooks GA, Packer L, Dallman PR. PMID: 6742115.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    196. Mitochondrial NADH dehydrogenase-catalyzed oxygen radical production by adriamycin, and the relative inactivity of 5-iminodaunorubicin. FEBS Lett. 1983 Mar 07; 153(1):227-30. Davies KJ, Doroshow JH, Hochstein P. PMID: 6298008.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    197. Free radicals and tissue damage produced by exercise. Biochem Biophys Res Commun. 1982 Aug 31; 107(4):1198-205. Davies KJ, Quintanilha AT, Brooks GA, Packer L. PMID: 6291524.
      View in: PubMed   Mentions: 325     Fields:    Translation:AnimalsCells
    198. Muscle mitochondrial bioenergetics, oxygen supply, and work capacity during dietary iron deficiency and repletion. Am J Physiol. 1982 Jun; 242(6):E418-27. Davies KJ, Maguire JJ, Brooks GA, Dallman PR, Packer L. PMID: 7091311.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    199. Exercise bioenergetics following sprint training. Arch Biochem Biophys. 1982 Apr 15; 215(1):260-5. Davies KJ, Packer L, Brooks GA. PMID: 7092228.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    200. Vitamin E deficiency and photosensitization of electron-transport carriers in microsomes. FEBS Lett. 1982 Mar 22; 139(2):241-4. Quintanilha AT, Davies KJ. PMID: 6804266.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    201. Effects of dietary iron deficiency of iron-sulfur proteins and bioenergetic functions of skeletal muscle mitochondria. Biochim Biophys Acta. 1982 Feb 17; 679(2):210-20. Maguire JJ, Davies KJ, Dallman PR, Packer L. PMID: 7059584.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    202. Membrane effects of vitamin E deficiency: bioenergetic and surface charge density studies of skeletal muscle and liver mitochondria. Ann N Y Acad Sci. 1982; 393:32-47. Quintanilha AT, Packer L, Davies JM, Racanelli TL, Davies KJ. PMID: 6959560.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    203. Biochemical adaptation of mitochondria, muscle, and whole-animal respiration to endurance training. Arch Biochem Biophys. 1981 Jul; 209(2):539-54. Davies KJ, Packer L, Brooks GA. PMID: 7294809.
      View in: PubMed   Mentions: 83     Fields:    Translation:AnimalsCells