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Kelvin J. A. Davies, PhD, DSc

TitleJames E. Birren Chair in Gerontology, Vice Dean of The USC Davis School (Dean of Faculty & Dean of Research), Director of The Ethel Percy andrus Gerontology Center, Director of USC Free Radi...
InstitutionUniversity of Southern California
DepartmentGerontology
Address3715 McClintock Avenue, GER 112A
University Park Campus
Los Angeles CA 90089-0191
Phone+1 213 740 8959
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    Collapse Biography 
    Collapse Awards and Honors
    University of Gdansk 199550th Anniversary Medal
    Society for Free Radical Biology & Medicine2006Lifetime Scientific Achievement Award
    Society for Free Radical Biology & Medicine2006Lifetime Scientific Achievement Award
    American College of Sports Medicine2007Presidential Award

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    Collapse Overview
    Kelvin J. A. Davies, Ph.D., D.Sc. is the James E. Birren Chair of Gerontology. Professor Davies was born and raised in London, England and is a dual citizen of Great Britain and the U.S.A. Educated at London University, Liverpool & Lancaster Universities, the University of Wisconsin, the University of California at Berkeley, and Harvard, he was previously a faculty member at Harvard University and Harvard Medical School. Before moving to USC’s Andrus Gerontology Center in 1996, Professor Davies was Chairman of the Department of Biochemistry & Molecular Biology at the Albany Medical College in New York, where he was also John A. Muntz University Professor and Distinguished Professor of Molecular Medicine.

    Deeply involved in research into oxidative stress and free radicals, Professor Davies is the (founding) Editor-in-Chief of the premier scientific journal in the field, Free Radical Biology & Medicine. Professor Davies is a Fellow of the Oxygen Society; a Fellow of the Society for Free Radical Biology & Medicine; a Fellow of the Gerontological Society of America; a Fellow of the American Association for the Advancement of Science; a Fellow of the Royal Institution (London); winner of the Harwood S. Belding award of the American Physiological Society; and holder of various medals, honorary degrees, and fellowships from several universities and scientific societies. Professor Davies is past President of the Society for Free Radical Biology & Medicine and the International Society for Free Radical Research. In 1996, he was named the National Parkinson Foundation Scholar. Recently he was awarded the Gold Medal of the European Society for Free Radical Research, and in 2012 Professor Davies was knighted as a Chevalier de l’Ordre National du Mérite de France (Knight, National Order of Merit of France) by the President of France.

    During aging, and in several age-related disease processes, vital cellular proteins, lipids, and DNA and RNA are damaged by free radicals produced by metabolism, chronic inflammation, radiation, smoke, pollution, and by many foods and drugs. These oxidized, non-functional, or dysfunctional cellular constituents must be removed or repaired before they cause further cell damage.

    Professor Davies’ research centers on the role of free radicals and oxidative stress in biology. In particular he is interested in genes that repair oxidatively damaged proteins, lipids, RNA, and DNA, and his laboratory has made major contributions to our understanding of this subject over the past twenty years. At the Andrus Gerontology Center, Professor Davies is focusing his research on the regulation of oxidative stress repair genes during aging. His laboratory is involved in biochemical, molecular biology, and genetic studies of both normal aging processes, and aging pathologies such as Alzheimer and Huntington diseases.


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Pomatto LCD, Davies KJA. ADAPTIVE HOMEOSTASIS AND THE FREE RADICAL THEORY OF AGEING. Free Radic Biol Med. 2018 Jun 27. PMID: 29960100.
      View in: PubMed
    2. Vliet AV, Dick TP, Aust SD, Koppenol WH, Ursini F, Kettle AJ, Beckman JS, O'Donnell V, Darley-Usmar V, Lancaster J, Hogg N, Davies KJA, Forman HJ, Janssen-Heininger YMW. Rust never sleeps: The continuing story of the Iron Bolt. Free Radic Biol Med. 2018 Jun 15. PMID: 29913216.
      View in: PubMed
    3. Pomatto LCD, Sun PY, Davies KJA. To Adapt or not to Adapt: Consequences of Declining Adaptive Homeostasis and Proteostasis with Age. Mech Ageing Dev. 2018 May 17. PMID: 29778759.
      View in: PubMed
    4. das Graças Fedoce A, Ferreira F, Bota RG, Bonet-Costa V, Sun PY, Davies KJA. The role of oxidative stress in anxiety disorder: cause or consequence? Free Radic Res. 2018 May 09; 1-11. PMID: 29742940.
      View in: PubMed
    5. Davies KJA. Cardiovascular Adaptive Homeostasis in Exercise. Front Physiol. 2018; 9:369. PMID: 29765327.
      View in: PubMed
    6. Pomatto LCD, Cline M, Woodward N, Pakbin P, Sioutas C, Morgan TE, Finch CE, Forman HJ, Davies KJA. Aging attenuates redox adaptive homeostasis and proteostasis in female mice exposed to traffic-derived nanoparticles ('vehicular smog'). Free Radic Biol Med. 2018 Apr 27; 121:86-97. PMID: 29709705.
      View in: PubMed
    7. Pomatto LCD, Wong S, Tower J, Davies KJA. Sex-specific adaptive homeostasis in D. melanogaster depends on increased proteolysis by the 20S Proteasome: Data-in-Brief. Data Brief. 2018 Apr; 17:653-661. PMID: 29552615.
      View in: PubMed
    8. Pomatto LCD, Tower J, Davies KJA. Sexual Dimorphism and Aging Differentially Regulate Adaptive Homeostasis. J Gerontol A Biol Sci Med Sci. 2018 Jan 16; 73(2):141-149. PMID: 28525535.
      View in: PubMed
    9. Walker CL, Pomatto LCD, Tripathi DN, Davies KJA. Redox Regulation of Homeostasis and Proteostasis in Peroxisomes. Physiol Rev. 2018 Jan 01; 98(1):89-115. PMID: 29167332.
      View in: PubMed
    10. Davies JMS, Cillard J, Friguet B, Cadenas E, Cadet J, Cayce R, Fishmann A, Liao D, Bulteau AL, Derbré F, Rébillard A, Burstein S, Hirsch E, Kloner RA, Jakowec M, Petzinger G, Sauce D, Sennlaub F, Limon I, Ursini F, Maiorino M, Economides C, Pike CJ, Cohen P, Salvayre AN, Halliday MR, Lundquist AJ, Jakowec NA, Mechta-Grigoriou F, Mericskay M, Mariani J, Li Z, Huang D, Grant E, Forman HJ, Finch CE, Sun PY, Pomatto LCD, Agbulut O, Warburton D, Neri C, Rouis M, Cillard P, Capeau J, Rosenbaum J, Davies KJA. The Oxygen Paradox, the French Paradox, and age-related diseases. Geroscience. 2017 12; 39(5-6):499-550. PMID: 29270905.
      View in: PubMed
    11. Pomatto LCD, Davies KJA. The role of declining adaptive homeostasis in ageing. J Physiol. 2017 Dec 15; 595(24):7275-7309. PMID: 29028112.
      View in: PubMed
    12. Pomatto LCD, Wong S, Tower J, Davies KJA. Sexual dimorphism in oxidant-induced adaptive homeostasis in multiple wild-type D. melanogaster strains. Arch Biochem Biophys. 2017 12 15; 636:57-70. PMID: 29100984.
      View in: PubMed
    13. Lomeli N, Bota DA, Davies KJA. Diminished stress resistance and defective adaptive homeostasis in age-related diseases. Clin Sci (Lond). 2017 Nov 01; 131(21):2573-2599. PMID: 29070521.
      View in: PubMed
    14. Zhou L, Zhang H, Davies KJA, Forman HJ. Aging-related decline in the induction of Nrf2-regulated antioxidant genes in human bronchial epithelial cells. Redox Biol. 2018 Apr; 14:35-40. PMID: 28863281.
      View in: PubMed
    15. Koltai E, Bori Z, Chabert C, Dubouchaud H, Naito H, Machida S, Davies KJ, Murlasits Z, Fry AC, Boldogh I, Radak Z. SIRT1 may play a crucial role in overload-induced hypertrophy of skeletal muscle. J Physiol. 2017 Jun 01; 595(11):3361-3376. PMID: 28251652.
      View in: PubMed
    16. Pomatto LCD, Wong S, Carney C, Shen B, Tower J, Davies KJA. The age- and sex-specific decline of the 20s proteasome and the Nrf2/CncC signal transduction pathway in adaption and resistance to oxidative stress in Drosophila melanogaster. Aging (Albany NY). 2017 Apr; 9(4):1153-1185. PMID: 28373600.
      View in: PubMed
    17. Cadet J, Davies KJA. Oxidative DNA damage & repair: An introduction. Free Radic Biol Med. 2017 06; 107:2-12. PMID: 28363603.
      View in: PubMed
    18. Cadet J, Davies KJA, Medeiros MH, Di Mascio P, Wagner JR. Formation and repair of oxidatively generated damage in cellular DNA. Free Radic Biol Med. 2017 06; 107:13-34. PMID: 28057600.
      View in: PubMed
    19. Pomatto LCD, Carney C, Shen B, Wong S, Halaszynski K, Salomon MP, Davies KJA, Tower J. The Mitochondrial Lon Protease Is Required for Age-Specific and Sex-Specific Adaptation to Oxidative Stress. Curr Biol. 2017 Jan 09; 27(1):1-15. PMID: 27916526.
      View in: PubMed
    20. Bonet-Costa V, Pomatto LC, Davies KJ. The Proteasome and Oxidative Stress in Alzheimer's Disease. Antioxid Redox Signal. 2016 12 01; 25(16):886-901. PMID: 27392670.
      View in: PubMed
    21. Forman HJ, Bernardo A, Davies KJ. Corrigendum to "What is the concentration of hydrogen peroxide in blood and plasma?" [Arch. Biochem. Biophys. 603 (2016) 48-53]. Arch Biochem Biophys. 2016 Oct 01; 607:7. PMID: 27552737.
      View in: PubMed
    22. Reeg S, Jung T, Castro JP, Davies KJA, Henze A, Grune T. The molecular chaperone Hsp70 promotes the proteolytic removal of oxidatively damaged proteins by the proteasome. Free Radic Biol Med. 2016 10; 99:153-166. PMID: 27498116.
      View in: PubMed
    23. Bota DA, Davies KJ. Mitochondrial Lon protease in human disease and aging: Including an etiologic classification of Lon-related diseases and disorders. Free Radic Biol Med. 2016 11; 100:188-198. PMID: 27387767.
      View in: PubMed
    24. Raynes R, Juarez C, Pomatto LC, Sieburth D, Davies KJ. Aging and SKN-1-dependent Loss of 20S Proteasome Adaptation to Oxidative Stress in C. elegans. J Gerontol A Biol Sci Med Sci. 2017 Feb; 72(2):143-151. PMID: 27341854.
      View in: PubMed
    25. Forman HJ, Bernardo A, Davies KJ. What is the concentration of hydrogen peroxide in blood and plasma? Arch Biochem Biophys. 2016 08 01; 603:48-53. PMID: 27173735.
      View in: PubMed
    26. Raynes R, Pomatto LC, Davies KJ. Degradation of oxidized proteins by the proteasome: Distinguishing between the 20S, 26S, and immunoproteasome proteolytic pathways. Mol Aspects Med. 2016 08; 50:41-55. PMID: 27155164; PMCID: PMC4967006 [Available on 08/01/17].
    27. Davies KJ. Adaptive homeostasis. Mol Aspects Med. 2016 06; 49:1-7. PMID: 27112802; PMCID: PMC4868097 [Available on 06/01/17].
    28. Johnston-Carey HK, Pomatto LC, Davies KJ. The Immunoproteasome in oxidative stress, aging, and disease. Crit Rev Biochem Mol Biol. 2015 Jul-Aug; 51(4):268-81. PMID: 27098648; PMCID: PMC4968084 [Available on 04/20/17].
    29. Davies KJ. The Oxygen Paradox, oxidative stress, and ageing. Arch Biochem Biophys. 2016 Apr 01; 595:28-32. PMID: 27095211; PMCID: PMC4838776 [Available on 04/01/17].
    30. Appenzeller-Herzog C, Bánhegyi G, Bogeski I, Davies KJ, Delaunay-Moisan A, Forman HJ, Görlach A, Kietzmann T, Laurindo F, Margittai E, Meyer AJ, Riemer J, Rützler M, Simmen T, Sitia R, Toledano MB, Touw IP. Transit of H2O2 across the endoplasmic reticulum membrane is not sluggish. Free Radic Biol Med. 2016 05; 94:157-60. PMID: 26928585.
      View in: PubMed
    31. Pomatto LC, Raynes R, Davies KJ. The peroxisomal Lon protease LonP2 in aging and disease: functions and comparisons with mitochondrial Lon protease LonP1. Biol Rev Camb Philos Soc. 2017 May; 92(2):739-753. PMID: 26852705.
      View in: PubMed
    32. Forman HJ, Davies KJA. Commentary on "Bach1 differentially regulates distinct Nrf2-dependent genes in human venous and coronary artery endothelial cells adapted to physiological oxygen levels" by Chapple et al. Free Radic Biol Med. 2016 Mar; 92:163-164. PMID: 26802904.
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    33. Emrani R, Rébillard A, Lefeuvre L, Gratas-Delamarche A, Davies KJ, Cillard J. The calcineurin antagonist RCAN1-4 is induced by exhaustive exercise in rat skeletal muscle. Free Radic Biol Med. 2015 Oct; 87:290-9. PMID: 26122706.
      View in: PubMed
    34. Zhang H, Davies KJA, Forman HJ. Oxidative stress response and Nrf2 signaling in aging. Free Radic Biol Med. 2015 Nov; 88(Pt B):314-336. PMID: 26066302; PMCID: PMC4628850 [Available on 11/01/16].
    35. Zhang H, Davies KJ, Forman HJ. TGFß1 rapidly activates Src through a non-canonical redox signaling mechanism. Arch Biochem Biophys. 2015 Feb 15; 568:1-7. PMID: 25585026; PMCID: PMC4339486.
    36. Emrani Bidi R, Rebillard A, Saligaut D, Delamarche A, Davies KJ, Cillard J. Acute Electrical Pulse Stimulation and Hyperglycemia Regulates RCAN1-4 in C2C12 myotubes through Oxidative Stress. Free Radic Biol Med. 2014 Oct; 75 Suppl 1:S29. PMID: 26461328.
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    37. Davies KJ. What Goes Wrong with Lon in Ageing? Free Radic Biol Med. 2014 Oct; 75 Suppl 1:S6. PMID: 26461412.
      View in: PubMed
    38. Forman HJ, Augusto O, Brigelius-Flohe R, Dennery PA, Kalyanaraman B, Ischiropoulos H, Mann GE, Radi R, Roberts LJ, Vina J, Davies KJ. Even free radicals should follow some rules: a guide to free radical research terminology and methodology. Free Radic Biol Med. 2015 Jan; 78:233-5. PMID: 25462642.
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    39. Marton O, Koltai E, Takeda M, Koch LG, Britton SL, Davies KJ, Boldogh I, Radak Z. Mitochondrial biogenesis-associated factors underlie the magnitude of response to aerobic endurance training in rats. Pflugers Arch. 2015 Apr; 467(4):779-88. PMID: 24943897; PMCID: PMC4272336.
    40. Andersen JK, Davies KJ, Forman HJ. Reactive oxygen and nitrogen species in neurodegeneration. Free Radic Biol Med. 2013 Sep; 62:1-3. PMID: 23876468.
      View in: PubMed
    41. Forman HJ, Davies KJ, Ursini F. How do nutritional antioxidants really work: nucleophilic tone and para-hormesis versus free radical scavenging in vivo. Free Radic Biol Med. 2014 Jan; 66:24-35. PMID: 23747930; PMCID: PMC3852196.
    42. Hart N, Sarga L, Csende Z, Koch LG, Britton SL, Davies KJ, Radak Z. Resveratrol attenuates exercise-induced adaptive responses in rats selectively bred for low running performance. Dose Response. 2014 Jan; 12(1):57-71. PMID: 24659933; PMCID: PMC3960954.
    43. Hart N, Sarga L, Csende Z, Koltai E, Koch LG, Britton SL, Davies KJ, Kouretas D, Wessner B, Radak Z. Resveratrol enhances exercise training responses in rats selectively bred for high running performance. Food Chem Toxicol. 2013 Nov; 61:53-9. PMID: 23422033; PMCID: PMC3703486.
    44. Ngo JK, Pomatto LC, Davies KJ. Upregulation of the mitochondrial Lon Protease allows adaptation to acute oxidative stress but dysregulation is associated with chronic stress, disease, and aging. Redox Biol. 2013 Feb 09; 1:258-64. PMID: 24024159; PMCID: PMC3757690.
    45. Ermak G, Davies KJ. Chronic high levels of the RCAN1-1 protein may promote neurodegeneration and Alzheimer disease. Free Radic Biol Med. 2013 Sep; 62:47-51. PMID: 23369757; PMCID: PMC4720382.
    46. Chepelev NL, Zhang H, Liu H, McBride S, Seal AJ, Morgan TE, Finch CE, Willmore WG, Davies KJ, Forman HJ. Competition of nuclear factor-erythroid 2 factors related transcription factor isoforms, Nrf1 and Nrf2, in antioxidant enzyme induction. Redox Biol. 2013; 1:183-9. PMID: 24024152; PMCID: PMC3757680.
    47. Pickering AM, Staab TA, Tower J, Sieburth D, Davies KJ. A conserved role for the 20S proteasome and Nrf2 transcription factor in oxidative stress adaptation in mammals, Caenorhabditis elegans and Drosophila melanogaster. J Exp Biol. 2013 Feb 15; 216(Pt 4):543-53. PMID: 23038734; PMCID: PMC3561776.
    48. Koltai E, Hart N, Taylor AW, Goto S, Ngo JK, Davies KJ, Radak Z. Age-associated declines in mitochondrial biogenesis and protein quality control factors are minimized by exercise training. Am J Physiol Regul Integr Comp Physiol. 2012 Jul 15; 303(2):R127-34. PMID: 22573103; PMCID: PMC3404634.
    49. Pickering AM, Davies KJ. Differential roles of proteasome and immunoproteasome regulators Pa28aß, Pa28? and Pa200 in the degradation of oxidized proteins. Arch Biochem Biophys. 2012 Jul 15; 523(2):181-90. PMID: 22564544; PMCID: PMC3384713.
    50. Zhang H, Liu H, Davies KJ, Sioutas C, Finch CE, Morgan TE, Forman HJ. Nrf2-regulated phase II enzymes are induced by chronic ambient nanoparticle exposure in young mice with age-related impairments. Free Radic Biol Med. 2012 May 01; 52(9):2038-46. PMID: 22401859; PMCID: PMC3342863.
    51. Ermak G, Sojitra S, Yin F, Cadenas E, Cuervo AM, Davies KJ. Chronic expression of RCAN1-1L protein induces mitochondrial autophagy and metabolic shift from oxidative phosphorylation to glycolysis in neuronal cells. J Biol Chem. 2012 Apr 20; 287(17):14088-98. PMID: 22389495; PMCID: PMC3340208.
    52. Zhang H, Liu H, Borok Z, Davies KJ, Ursini F, Forman HJ. Cigarette smoke extract stimulates epithelial-mesenchymal transition through Src activation. Free Radic Biol Med. 2012 Apr 15; 52(8):1437-42. PMID: 22342303; PMCID: PMC3312989.
    53. Pickering AM, Linder RA, Zhang H, Forman HJ, Davies KJ. Nrf2-dependent induction of proteasome and Pa28aß regulator are required for adaptation to oxidative stress. J Biol Chem. 2012 Mar 23; 287(13):10021-31. PMID: 22308036; PMCID: PMC3323025.
    54. Pickering AM, Davies KJ. Degradation of damaged proteins: the main function of the 20S proteasome. Prog Mol Biol Transl Sci. 2012; 109:227-48. PMID: 22727423; PMCID: PMC3710712.
    55. Kalyanaraman B, Darley-Usmar V, Davies KJ, Dennery PA, Forman HJ, Grisham MB, Mann GE, Moore K, Roberts LJ, Ischiropoulos H. Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations. Free Radic Biol Med. 2012 Jan 01; 52(1):1-6. PMID: 22027063; PMCID: PMC3911769.
    56. Pickering AM, Davies KJ. A simple fluorescence labeling method for studies of protein oxidation, protein modification, and proteolysis. Free Radic Biol Med. 2012 Jan 15; 52(2):239-46. PMID: 21988844; PMCID: PMC4212338.
    57. Ngo JK, Pomatto LC, Bota DA, Koop AL, Davies KJ. Impairment of lon-induced protection against the accumulation of oxidized proteins in senescent wi-38 fibroblasts. J Gerontol A Biol Sci Med Sci. 2011 Nov; 66(11):1178-85. PMID: 21868393; PMCID: PMC3193527.
    58. Grune T, Catalgol B, Licht A, Ermak G, Pickering AM, Ngo JK, Davies KJ. HSP70 mediates dissociation and reassociation of the 26S proteasome during adaptation to oxidative stress. Free Radic Biol Med. 2011 Oct 01; 51(7):1355-64. PMID: 21767633; PMCID: PMC3172204.
    59. Ermak G, Pritchard MA, Dronjak S, Niu B, Davies KJ. Do RCAN1 proteins link chronic stress with neurodegeneration? FASEB J. 2011 Oct; 25(10):3306-11. PMID: 21680892; PMCID: PMC3971512.
    60. Davies KJ, Forman HJ. RasGrf1 and aging. Aging (Albany NY). 2011 May; 3(5):455. PMID: 21666282; PMCID: PMC3156594.
    61. Lloret A, Badia MC, Giraldo E, Ermak G, Alonso MD, Pallardó FV, Davies KJ, Viña J. Amyloid-ß toxicity and tau hyperphosphorylation are linked via RCAN1 in Alzheimer's disease. J Alzheimers Dis. 2011; 27(4):701-9. PMID: 21876249; PMCID: PMC3690537.
    62. Pickering AM, Koop AL, Teoh CY, Ermak G, Grune T, Davies KJ. The immunoproteasome, the 20S proteasome and the PA28aß proteasome regulator are oxidative-stress-adaptive proteolytic complexes. Biochem J. 2010 Dec 15; 432(3):585-94. PMID: 20919990; PMCID: PMC3133595.
    63. Davies KJ. The evolution of Free Radical Biology & Medicine: still radical after a quarter of a century! Free Radic Biol Med. 2010 Dec 15; 49(12):1825-33. PMID: 21146787.
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    64. Costa V, Giacomello M, Hudec R, Lopreiato R, Ermak G, Lim D, Malorni W, Davies KJ, Carafoli E, Scorrano L. Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli. EMBO Mol Med. 2010 Dec; 2(12):490-503. PMID: 21069748; PMCID: PMC3044888.
    65. Grimm S, Hoehn A, Davies KJ, Grune T. Protein oxidative modifications in the ageing brain: consequence for the onset of neurodegenerative disease. Free Radic Res. 2011 Jan; 45(1):73-88. PMID: 20815785; PMCID: PMC3675897.
    66. Grune T, Botzen D, Engels M, Voss P, Kaiser B, Jung T, Grimm S, Ermak G, Davies KJ. Tau protein degradation is catalyzed by the ATP/ubiquitin-independent 20S proteasome under normal cell conditions. Arch Biochem Biophys. 2010 Aug 15; 500(2):181-8. PMID: 20478262; PMCID: PMC2904402.
    67. Ermak G, Hench KJ, Chang KT, Sachdev S, Davies KJ. Regulator of calcineurin (RCAN1-1L) is deficient in Huntington disease and protective against mutant huntingtin toxicity in vitro. J Biol Chem. 2009 May 01; 284(18):11845-53. PMID: 19270310; PMCID: PMC2673253.
    68. Ngo JK, Davies KJ. Mitochondrial Lon protease is a human stress protein. Free Radic Biol Med. 2009 Apr 15; 46(8):1042-8. PMID: 19439239; PMCID: PMC3093304.
    69. Radak Z, Atalay M, Jakus J, Boldogh I, Davies K, Goto S. Exercise improves import of 8-oxoguanine DNA glycosylase into the mitochondrial matrix of skeletal muscle and enhances the relative activity. Free Radic Biol Med. 2009 Jan 15; 46(2):238-43. PMID: 18992806; PMCID: PMC3032603.
    70. Nogalska A, D'Agostino C, Engel WK, Davies KJ, Askanas V. Decreased SIRT1 deacetylase activity in sporadic inclusion-body myositis muscle fibers. Neurobiol Aging. 2010 Sep; 31(9):1637-48. PMID: 18922603.
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    71. Ngo JK, Davies KJ. Importance of the lon protease in mitochondrial maintenance and the significance of declining lon in aging. Ann N Y Acad Sci. 2007 Nov; 1119:78-87. PMID: 18056957.
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    72. Sachdev S, Davies KJ. Production, detection, and adaptive responses to free radicals in exercise. Free Radic Biol Med. 2008 Jan 15; 44(2):215-23. PMID: 18191757.
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    73. Brigelius-Flohé R, Davies KJ. Is vitamin E an antioxidant, a regulator of signal transduction and gene expression, or a 'junk' food? Comments on the two accompanying papers: "Molecular mechanism of alpha-tocopherol action" by A. Azzi and "Vitamin E, antioxidant and nothing more" by M. Traber and J. Atkinson. Free Radic Biol Med. 2007 Jul 01; 43(1):2-3. PMID: 17561087.
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    74. Davies KJ, Ermak G, Rothermel BA, Pritchard M, Heitman J, Ahnn J, Henrique-Silva F, Crawford D, Canaider S, Strippoli P, Carinci P, Min KT, Fox DS, Cunningham KW, Bassel-Duby R, Olson EN, Zhang Z, Williams RS, Gerber HP, Pérez-Riba M, Seo H, Cao X, Klee CB, Redondo JM, Maltais LJ, Bruford EA, Povey S, Molkentin JD, McKeon FD, Duh EJ, Crabtree GR, Cyert MS, de la Luna S, Estivill X. Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin. FASEB J. 2007 Oct; 21(12):3023-8. PMID: 17595344.
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    75. Packer L, Cadenas E, Davies KJ. Free radicals and exercise: an introduction. Free Radic Biol Med. 2008 Jan 15; 44(2):123-5. PMID: 18191747.
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    76. Harris CD, Ermak G, Davies KJ. RCAN1-1L is overexpressed in neurons of Alzheimer's disease patients. FEBS J. 2007 Apr; 274(7):1715-24. PMID: 17331188.
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    77. Poppek D, Keck S, Ermak G, Jung T, Stolzing A, Ullrich O, Davies KJ, Grune T. Phosphorylation inhibits turnover of the tau protein by the proteasome: influence of RCAN1 and oxidative stress. Biochem J. 2006 Dec 15; 400(3):511-20. PMID: 16939415; PMCID: PMC1698600.
    78. Powell SR, Davies KJ, Divald A. Optimal determination of heart tissue 26S-proteasome activity requires maximal stimulating ATP concentrations. J Mol Cell Cardiol. 2007 Jan; 42(1):265-9. PMID: 17140599; PMCID: PMC1820868.
    79. Ermak G, Harris CD, Battocchio D, Davies KJ. RCAN1 (DSCR1 or Adapt78) stimulates expression of GSK-3beta. FEBS J. 2006 May; 273(10):2100-9. PMID: 16649988.
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    80. Pryor WA, Houk KN, Foote CS, Fukuto JM, Ignarro LJ, Squadrito GL, Davies KJ. Free radical biology and medicine: it's a gas, man! Am J Physiol Regul Integr Comp Physiol. 2006 Sep; 291(3):R491-511. PMID: 16627692.
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    81. Davies KJ, Shringarpure R. Preferential degradation of oxidized proteins by the 20S proteasome may be inhibited in aging and in inflammatory neuromuscular diseases. Neurology. 2006 Jan 24; 66(2 Suppl 1):S93-6. PMID: 16432154.
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    82. Grune T, Merker K, Jung T, Sitte N, Davies KJ. Protein oxidation and degradation during postmitotic senescence. Free Radic Biol Med. 2005 Nov 01; 39(9):1208-15. PMID: 16214036.
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    83. Davies KJ, Pryor WA. The evolution of Free Radical Biology & Medicine: a 20-year history. Free Radic Biol Med. 2005 Nov 15; 39(10):1263-4. PMID: 16257637.
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    84. Fratta P, Engel WK, McFerrin J, Davies KJ, Lin SW, Askanas V. Proteasome inhibition and aggresome formation in sporadic inclusion-body myositis and in amyloid-beta precursor protein-overexpressing cultured human muscle fibers. Am J Pathol. 2005 Aug; 167(2):517-26. PMID: 16049336; PMCID: PMC1603556.
    85. Powell SR, Wang P, Katzeff H, Shringarpure R, Teoh C, Khaliulin I, Das DK, Davies KJ, Schwalb H. Oxidized and ubiquitinated proteins may predict recovery of postischemic cardiac function: essential role of the proteasome. Antioxid Redox Signal. 2005 May-Jun; 7(5-6):538-46. PMID: 15889999.
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    86. Powell SR, Wang P, Divald A, Teichberg S, Haridas V, McCloskey TW, Davies KJ, Katzeff H. Aggregates of oxidized proteins (lipofuscin) induce apoptosis through proteasome inhibition and dysregulation of proapoptotic proteins. Free Radic Biol Med. 2005 Apr 15; 38(8):1093-101. PMID: 15780767.
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    87. Bota DA, Ngo JK, Davies KJ. Downregulation of the human Lon protease impairs mitochondrial structure and function and causes cell death. Free Radic Biol Med. 2005 Mar 01; 38(5):665-77. PMID: 15683722.
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    89. Teoh CY, Davies KJ. Potential roles of protein oxidation and the immunoproteasome in MHC class I antigen presentation: the 'PrOxI' hypothesis. Arch Biochem Biophys. 2004 Mar 01; 423(1):88-96. PMID: 14871471.
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    90. Azzi A, Davies KJ, Kelly F. Free radical biology - terminology and critical thinking. FEBS Lett. 2004 Jan 30; 558(1-3):3-6. PMID: 14982062.
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    91. Ermak G, Cheadle C, Becker KG, Harris CD, Davies KJ. DSCR1(Adapt78) modulates expression of SOD1. FASEB J. 2004 Jan; 18(1):62-9. PMID: 14718387.
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    92. Ermak G, Figge JJ, Kartel NA, Davies KJ. Genetic aberrations in Chernobyl-related thyroid cancers: implications for possible future nuclear accidents or nuclear attacks. IUBMB Life. 2003 Dec; 55(12):637-41. PMID: 14768999.
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    93. Grune T, Davies KJ. The proteasomal system and HNE-modified proteins. Mol Aspects Med. 2003 Aug-Oct; 24(4-5):195-204. PMID: 12892997.
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    94. Ermak G, Cancasci VJ, Davies KJ. Cytotoxic effect of doxycycline and its implications for tet-on gene expression systems. Anal Biochem. 2003 Jul 01; 318(1):152-4. PMID: 12782044.
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    96. Demasi M, Davies KJ. Proteasome inhibitors induce intracellular protein aggregation and cell death by an oxygen-dependent mechanism. FEBS Lett. 2003 May 08; 542(1-3):89-94. PMID: 12729904.
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    97. Ermak G, Davies KJ. DSCR1(Adapt78)--a Janus gene providing stress protection but causing Alzheimer's disease? IUBMB Life. 2003 Jan; 55(1):29-31. PMID: 12716059.
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    98. Wang Y, Davies KJ, Melendez JA, Crawford DR. Characterization of adapt33, a stress-inducible riboregulator. Gene Expr. 2003; 11(2):85-94. PMID: 12837039.
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    99. Bota DA, Van Remmen H, Davies KJ. Modulation of Lon protease activity and aconitase turnover during aging and oxidative stress. FEBS Lett. 2002 Dec 04; 532(1-2):103-6. PMID: 12459471.
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    100. Shringarpure R, Grune T, Mehlhase J, Davies KJ. Ubiquitin conjugation is not required for the degradation of oxidized proteins by proteasome. J Biol Chem. 2003 Jan 03; 278(1):311-8. PMID: 12401807.
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    101. Grune T, Reinheckel T, North JA, Li R, Bescos PB, Shringarpure R, Davies KJ. Ezrin turnover and cell shape changes catalyzed by proteasome in oxidatively stressed cells. FASEB J. 2002 Oct; 16(12):1602-10. PMID: 12374783.
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    102. Bota DA, Davies KJ. Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism. Nat Cell Biol. 2002 Sep; 4(9):674-80. PMID: 12198491.
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    103. Ursini F, Davies KJ, Maiorino M, Parasassi T, Sevanian A. Atherosclerosis: another protein misfolding disease? Trends Mol Med. 2002 Aug; 8(8):370-4. PMID: 12127722.
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    104. Ermak G, Davies KJ. Gene expression in Alzheimer's disease. Drugs Today (Barc). 2002 Jul; 38(7):509-16. PMID: 12582468.
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    105. Ermak G, Harris CD, Davies KJ. The DSCR1 (Adapt78) isoform 1 protein calcipressin 1 inhibits calcineurin and protects against acute calcium-mediated stress damage, including transient oxidative stress. FASEB J. 2002 Jun; 16(8):814-24. PMID: 12039863.
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    106. Shringarpure R, Davies KJ. Protein turnover by the proteasome in aging and disease. Free Radic Biol Med. 2002 Jun 01; 32(11):1084-9. PMID: 12031893.
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    107. Ermak G, Davies KJ. Calcium and oxidative stress: from cell signaling to cell death. Mol Immunol. 2002 Feb; 38(10):713-21. PMID: 11841831.
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    108. Grune T, Reinheckel T, Li R, North JA, Davies KJ. Proteasome-dependent turnover of protein disulfide isomerase in oxidatively stressed cells. Arch Biochem Biophys. 2002 Jan 15; 397(2):407-13. PMID: 11795901.
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    109. Crawford DR, Suzuki T, Sesay J, Davies KJ. Analysis of gene expression following oxidative stress. Methods Mol Biol. 2002; 196:155-62. PMID: 12152194.
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    110. Crawford DR, Kochheiser JC, Schools GP, Salmon SL, Davies KJ. Differential display: a critical analysis. Gene Expr. 2002; 10(3):101-7. PMID: 12064572.
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    111. Davies KJ, Harris CD, Ermak G. The essential role of calcium in induction of the DSCR1 (ADAPT78) gene. Biofactors. 2001; 15(2-4):91-3. PMID: 12016333.
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