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Julie E. Lang, MD

TitleAssociate Professor of Clinical Surgery
InstitutionUniversity of Southern California
DepartmentSurgery
Address1450 Biggy St.
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 6229
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    Other Positions
    TitleDirector, Breast Cancer Program, Department of Surgery


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    Julie Lang, MD, FACS is an Associate Professor at the Keck School of Medicine of USC. She earned her medical degree from the University of North Carolina, Chapel Hill. She then went on to complete a Surgery residency and a postdoctoral research fellowship in breast cancer research at the University of California, San Francisco. She completed her breast surgical oncology fellowship at the UT-MD Anderson Cancer Center in 2007. She served as the Director of Breast Surgical Oncology at the Arizona Cancer Center for 5 years, then joined the faculty of USC in 2012. Dr. Lang is an expert in the field of breast surgical oncology, with strong expertise in both clinical care and research in the field of breast cancer. She is experienced with advanced breast surgical techniques, such as skin sparing, nipple sparing mastectomies, and coordinating reconstructive surgery with colleagues in Plastic Surgery. Her research focuses on circulating tumor cells, clinical trials, locally advanced/inflammatory breast cancer and radiation-induced sarcoma. Dr. Lang is an avid breast cancer researcher and leads the Breast Surgical Oncology Translational Research Laboratory at the Norris Comprehensive Cancer Center. Dr. Lang is very patient centered and strives to utilize technology and evidenced based medicine to the benefit of her patients. She has published numerous peer reviewed articles and book chapters on the topic of breast cancer.


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lang J, Ring A, Porras T, Kaur P, Forte VA, Mineyev N, Tripathy D, Press MF, Campo D. RNA-Seq of Circulating Tumor Cells in Stage II-III Breast Cancer. Ann Surg Oncol. 2018 Jun 04. PMID: 29868978.
      View in: PubMed
    2. Iriondo O, Liu Y, Lee G, Elhodaky M, Jimenez C, Li L, Lang J, Wang P, Yu M. TAK1 mediates microenvironment-triggered autocrine signals and promotes triple-negative breast cancer lung metastasis. Nat Commun. 2018 May 18; 9(1):1994. PMID: 29777109.
      View in: PubMed
    3. Porras TB, Kaur P, Ring A, Schechter N, Lang J. Challenges in using liquid biopsies for gene expression profiling. Oncotarget. 2018 Jan 23; 9(6):7036-7053. PMID: 29467948.
      View in: PubMed
    4. Lang J, Tereffe W, Babiera G. Primary Locoregional Treatment in Metastatic Breast Cancer: A Reply. Ann Surg Oncol. 2017 Dec; 24(Suppl 3):579-580. PMID: 29147929.
      View in: PubMed
    5. Pan E, Tung L, Ragab O, Morocco E, Wecsler J, Sposto R, Raghavendra A, Chung E, Lang J. Inflammatory Breast Cancer Outcomes in a Contemporary Series. Anticancer Res. 2017 09; 37(9):5057-5063. PMID: 28870934.
      View in: PubMed
    6. Zoratti GL, Tanabe LM, Hyland TE, Duhaime MJ, Colombo É, Leduc R, Marsault E, Johnson MD, Lin CY, Boerner J, Lang J, List K. Matriptase regulates c-Met mediated proliferation and invasion in inflammatory breast cancer. Oncotarget. 2016 Sep 06; 7(36):58162-58173. PMID: 27528224.
      View in: PubMed
    7. Park JW, Liu MC, Yee D, Yau C, van 't Veer LJ, Symmans WF, Paoloni M, Perlmutter J, Hylton NM, Hogarth M, DeMichele A, Buxton MB, Chien AJ, Wallace AM, Boughey JC, Haddad TC, Chui SY, Kemmer KA, Kaplan HG, Isaacs C, Nanda R, Tripathy D, Albain KS, Edmiston KK, Elias AD, Northfelt DW, Pusztai L, Moulder SL, Lang J, Viscusi RK, Euhus DM, Haley BB, Khan QJ, Wood WC, Melisko M, Schwab R, Helsten T, Lyandres J, Davis SE, Hirst GL, Sanil A, Esserman LJ, Berry DA. Adaptive Randomization of Neratinib in Early Breast Cancer. N Engl J Med. 2016 Jul 07; 375(1):11-22. PMID: 27406346.
      View in: PubMed
    8. Rugo HS, Olopade OI, DeMichele A, Yau C, van 't Veer LJ, Buxton MB, Hogarth M, Hylton NM, Paoloni M, Perlmutter J, Symmans WF, Yee D, Chien AJ, Wallace AM, Kaplan HG, Boughey JC, Haddad TC, Albain KS, Liu MC, Isaacs C, Khan QJ, Lang J, Viscusi RK, Pusztai L, Moulder SL, Chui SY, Kemmer KA, Elias AD, Edmiston KK, Euhus DM, Haley BB, Nanda R, Northfelt DW, Tripathy D, Wood WC, Ewing C, Schwab R, Lyandres J, Davis SE, Hirst GL, Sanil A, Berry DA, Esserman LJ. Adaptive Randomization of Veliparib-Carboplatin Treatment in Breast Cancer. N Engl J Med. 2016 Jul 07; 375(1):23-34. PMID: 27406347.
      View in: PubMed
    9. Forte VA, Barrak DK, Elhodaky M, Tung L, Snow A, Lang J. The potential for liquid biopsies in the precision medical treatment of breast cancer. Cancer Biol Med. 2016 Mar; 13(1):19-40. PMID: 27144060; PMCID: PMC4850125.
    10. Ring A, Mineyev N, Zhu W, Park E, Lomas C, Punj V, Yu M, Barrak D, Forte V, Porras T, Tripathy D, Lang J. EpCAM based capture detects and recovers circulating tumor cells from all subtypes of breast cancer except claudin-low. Oncotarget. 2015 Dec 29; 6(42):44623-34. PMID: 26556851; PMCID: PMC4792580.
    11. López AM, Pruthi S, Boughey JC, Perloff M, Hsu CH, Lang J, Ley M, Frank D, Taverna JA, Chow HH. Double-Blind, Randomized Trial of Alternative Letrozole Dosing Regimens in Postmenopausal Women with Increased Breast Cancer Risk. Cancer Prev Res (Phila). 2016 Feb; 9(2):142-8. PMID: 26667449; PMCID: PMC4740217 [Available on 02/01/17].
    12. Cummins T, Yoon C, Choi H, Eliahoo P, Kim HH, Yamashita MW, Hovanessian-Larsen LJ, Lang J, Sener SF, Vallone J, Martin SE, Kirk Shung K. High-frequency ultrasound imaging for breast cancer biopsy guidance. J Med Imaging (Bellingham). 2015 Oct; 2(4):047001. PMID: 26693167; PMCID: PMC4675170 [Available on 12/10/16].
    13. O'Kelly Priddy CM, Forte VA, Lang J. The importance of surgical margins in breast cancer. J Surg Oncol. 2016 Mar; 113(3):256-63. PMID: 26394558.
      View in: PubMed
    14. Zoratti GL, Tanabe LM, Varela FA, Murray AS, Bergum C, Colombo É, Lang J, Molinolo AA, Leduc R, Marsault E, Boerner J, List K. Targeting matriptase in breast cancer abrogates tumour progression via impairment of stromal-epithelial growth factor signalling. Nat Commun. 2015 Apr 15; 6:6776. PMID: 25873032; PMCID: PMC4749267.
    15. Wecsler JS, Tereffe W, Pedersen RC, Sieffert MR, Mack WJ, Cui H, Russell CA, Woods RR, Viscusi RK, Sener SF, Lang J. Lymph node status in inflammatory breast cancer. Breast Cancer Res Treat. 2015 May; 151(1):113-20. PMID: 25846421.
      View in: PubMed
    16. Lang J, Zhu W, Nokes B, Sheth G, Novak P, Fuchs L, Watts G, Futscher B, Mineyev N, Ring A, LeBeau L, Nagle R, Cranmer L. Characterization of a novel radiation-induced sarcoma cell line. J Surg Oncol. 2015 May; 111(6):669-82. PMID: 25644184; PMCID: PMC4406876.
    17. Lang J, Scott JH, Wolf DM, Novak P, Punj V, Magbanua MJ, Zhu W, Mineyev N, Haqq CM, Crothers JR, Esserman LJ, Tripathy D, van 't Veer L, Park JW. Expression profiling of circulating tumor cells in metastatic breast cancer. Breast Cancer Res Treat. 2015 Jan; 149(1):121-31. PMID: 25432738; PMCID: PMC4698170.
    18. Poole BB, Wecsler JS, Sheth P, Sener SF, Wang L, Larsen L, Tripathy D, Lang J. Malignancy rates after surgical excision of discordant breast biopsies. J Surg Res. 2015 May 01; 195(1):152-7. PMID: 25519987.
      View in: PubMed
    19. Miller JA, Pappan K, Thompson PA, Want EJ, Siskos AP, Keun HC, Wulff J, Hu C, Lang J, Chow HH. Plasma metabolomic profiles of breast cancer patients after short-term limonene intervention. Cancer Prev Res (Phila). 2015 Jan; 8(1):86-93. PMID: 25388013; PMCID: PMC4289656.
    20. Wu T, Harder BG, Wong PK, Lang J, Zhang DD. Oxidative stress, mammospheres and Nrf2-new implication for breast cancer therapy? Mol Carcinog. 2015 Nov; 54(11):1494-502. PMID: 25154499; PMCID: PMC4697962 [Available on 11/01/16].
    21. Lang J, Wecsler JS, Press MF, Tripathy D. Molecular markers for breast cancer diagnosis, prognosis and targeted therapy. J Surg Oncol. 2015 Jan; 111(1):81-90. PMID: 25091830.
      View in: PubMed
    22. Davis GB, Lang J, Peric M, Yang H, Artenstein D, Chan LS, Schooler WG, Carey JN. Breast reconstruction satisfaction rates at a large county hospital. Ann Plast Surg. 2014 May; 72 Suppl 1:S61-5. PMID: 24691306.
      View in: PubMed
    23. Lang J, Summers DE, Cui H, Carey JN, Viscusi RK, Hurst CA, Waer AL, Ley ML, Sener SF, Vijayasekaran A. Trends in post-mastectomy reconstruction: a SEER database analysis. J Surg Oncol. 2013 Sep; 108(3):163-8. PMID: 23861196; PMCID: PMC4035023.
    24. Miller JA, Lang J, Ley M, Nagle R, Hsu CH, Thompson PA, Cordova C, Waer A, Chow HH. Human breast tissue disposition and bioactivity of limonene in women with early-stage breast cancer. Cancer Prev Res (Phila). 2013 Jun; 6(6):577-84. PMID: 23554130; PMCID: PMC3692564.
    25. Nokes B, Apel M, Jones C, Brown G, Lang J. Aminolevulinic acid (ALA): photodynamic detection and potential therapeutic applications. J Surg Res. 2013 May; 181(2):262-71. PMID: 23510551.
      View in: PubMed
    26. Lang J, Tereffe W, Mitchell MP, Rao R, Feng L, Meric-Bernstam F, Bedrosian I, Kuerer HM, Hunt KK, Hortobagyi GN, Babiera GV. Primary tumor extirpation in breast cancer patients who present with stage IV disease is associated with improved survival. Ann Surg Oncol. 2013 Jun; 20(6):1893-9. PMID: 23306905; PMCID: PMC4353581.
    27. Nokes BT, Cunliffe HE, Lafleur B, Mount DW, Livingston RB, Futscher BW, Lang J. In Vitro Assessment of the Inflammatory Breast Cancer Cell Line SUM 149: Discovery of 2 Single Nucleotide Polymorphisms in the RNase L Gene. J Cancer. 2013; 4(2):104-16. PMID: 23386909; PMCID: PMC3563072.
    28. Sheth GR, Cranmer LD, Smith BD, Grasso-Lebeau L, Lang J. Radiation-induced sarcoma of the breast: a systematic review. Oncologist. 2012; 17(3):405-18. PMID: 22334455; PMCID: PMC3316927.
    29. Liu LC, Lang J, Lu Y, Roe D, Hwang SE, Ewing CA, Esserman LJ, Morita E, Treseler P, Leong SP. Intraoperative frozen section analysis of sentinel lymph nodes in breast cancer patients: a meta-analysis and single-institution experience. Cancer. 2011 Jan 15; 117(2):250-8. PMID: 20818649.
      View in: PubMed
    30. Klein RL, Brown AR, Gomez-Castro CM, Chambers SK, Cragun JM, Grasso-Lebeau L, Lang J. Ovarian cancer metastatic to the breast presenting as inflammatory breast cancer: a case report and literature review. J Cancer. 2010 Jun 02; 1:27-31. PMID: 20842221; PMCID: PMC2931350.
    31. Lang J, Magbanua MJ, Scott JH, Makrigiorgos GM, Wang G, Federman S, Esserman LJ, Park JW, Haqq CM. A comparison of RNA amplification techniques at sub-nanogram input concentration. BMC Genomics. 2009 Jul 20; 10:326. PMID: 19619282; PMCID: PMC2724417.
    32. Lang J, Liu LC, Lu Y, Jenkins T, Hwang SE, Esserman LJ, Ewing CA, Alvarado M, Morita E, Treseler P, Leong SP. Prognostic implications of positive nonsentinel lymph nodes removed during selective sentinel lymphadenectomy for breast cancer. Breast J. 2009 May-Jun; 15(3):242-6. PMID: 19645778.
      View in: PubMed
    33. Liu LC, Lang J, Jenkins T, Lu Y, Ewing CA, Hwang SE, Sokol S, Alvarado M, Esserman LJ, Morita E, Treseler P, Leong SP. Is it necessary to harvest additional lymph nodes after resection of the most radioactive sentinel lymph node in breast cancer? J Am Coll Surg. 2008 Dec; 207(6):853-8. PMID: 19183531.
      View in: PubMed
    34. Lang J, Mosalpuria K, Cristofanilli M, Krishnamurthy S, Reuben J, Singh B, Bedrosian I, Meric-Bernstam F, Lucci A. HER2 status predicts the presence of circulating tumor cells in patients with operable breast cancer. Breast Cancer Res Treat. 2009 Feb; 113(3):501-7. PMID: 18327638.
      View in: PubMed
    35. Lang J, Kuerer HM. Breast ductal secretions: clinical features, potential uses, and possible applications. Cancer Control. 2007 Oct; 14(4):350-9. PMID: 17914335.
      View in: PubMed
    36. Lang J, Hall CS, Singh B, Lucci A. Significance of micrometastasis in bone marrow and blood of operable breast cancer patients: research tool or clinical application? Expert Rev Anticancer Ther. 2007 Oct; 7(10):1463-72. PMID: 17944570.
      View in: PubMed
    37. Lang J, Babiera GV. Locoregional Resection in Stage IV breast cancer: tumor biology, molecular and clinical perspectives. Surg Clin North Am. 2007 Apr; 87(2):527-38, xi-xii. PMID: 17498542.
      View in: PubMed
    38. Lang J, Esserman LJ, Ewing CA, Rugo HS, Lane KT, Leong SP, Hwang ES. Accuracy of selective sentinel lymphadenectomy after neoadjuvant chemotherapy: effect of clinical node status at presentation. J Am Coll Surg. 2004 Dec; 199(6):856-62. PMID: 15555967.
      View in: PubMed