Joseph T. Rodgers, PhD

TitleAssistant Professor of Stem Cell & Regenerative Medicine
InstitutionUniversity of Southern California
DepartmentStem Cell Biology & Regenerative Medicine
AddressBCC 301 1425 San Pablo St
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 865 1549
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    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Effects of aging on stem cell function through systemic signals and mTOR
    NIH/NIA R00AG041764Apr 1, 2016 - Mar 30, 2019
    Role: Principal Investigator
    Effects of aging on stem cell function through systemic signals and mTOR
    NIH/NIA K99AG041764Sep 30, 2012 - Aug 31, 2014
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Haller S, Kapuria S, Riley RR, O'Leary MN, Schreiber KH, Andersen JK, Melov S, Que J, Rando TA, Rock J, Kennedy BK, Rodgers J, Jasper H. mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance. Cell Stem Cell. 2017 Dec 07; 21(6):806-818.e5. PMID: 29220665.
      View in: PubMed
    2. Rodgers J, Schroeder MD, Ma C, Rando TA. HGFA Is an Injury-Regulated Systemic Factor that Induces the Transition of Stem Cells into GAlert. Cell Rep. 2017 04 18; 19(3):479-486. PMID: 28423312.
      View in: PubMed
    3. Rodgers J. Deteriorating Infrastructure in the Aged Muscle Stem Cell Niche. Cell Stem Cell. 2016 08 04; 19(2):150-151. PMID: 27494671.
      View in: PubMed
    4. Rodgers J, King KY, Brett JO, Cromie MJ, Charville GW, Maguire KK, Brunson C, Mastey N, Liu L, Tsai CR, Goodell MA, Rando TA. mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert). Nature. 2014 Jun 19; 510(7505):393-6. PMID: 24870234; PMCID: PMC4065227.
    5. Kraus D, Yang Q, Kong D, Banks AS, Zhang L, Rodgers J, Pirinen E, Pulinilkunnil TC, Gong F, Wang YC, Cen Y, Sauve AA, Asara JM, Peroni OD, Monia BP, Bhanot S, Alhonen L, Puigserver P, Kahn BB. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature. 2014 Apr 10; 508(7495):258-62. PMID: 24717514.
      View in: PubMed
    6. Hall JA, Tabata M, Rodgers J, Puigserver P. USP7 attenuates hepatic gluconeogenesis through modulation of FoxO1 gene promoter occupancy. Mol Endocrinol. 2014 Jun; 28(6):912-24. PMID: 24694308; PMCID: PMC4042075.
    7. Tabata M, Rodgers J, Hall JA, Lee Y, Jedrychowski MP, Gygi SP, Puigserver P. Cdc2-like kinase 2 suppresses hepatic fatty acid oxidation and ketogenesis through disruption of the PGC-1a and MED1 complex. Diabetes. 2014 May; 63(5):1519-32. PMID: 24458359; PMCID: PMC3994960.
    8. Rodgers J, Rando TA. Sprouting a new take on stem cell aging. EMBO J. 2012 Nov 05; 31(21):4103-5. PMID: 23042560; PMCID: PMC3492738.
    9. Rodgers J, Vogel RO, Puigserver P. Clk2 and B56ß mediate insulin-regulated assembly of the PP2A phosphatase holoenzyme complex on Akt. Mol Cell. 2011 Feb 18; 41(4):471-9. PMID: 21329884; PMCID: PMC3060660.
    10. Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Israelian K, Westphal CH, Rodgers J, Shioda T, Elson SL, Mulligan P, Najafi-Shoushtari H, Black JC, Thakur JK, Kadyk LC, Whetstine JR, Mostoslavsky R, Puigserver P, Li X, Dyson NJ, Hart AC, Näär AM. Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes Dev. 2010 Jul 01; 24(13):1403-17. PMID: 20595232; PMCID: PMC2895199.
    11. Rodgers J, Haas W, Gygi SP, Puigserver P. Cdc2-like kinase 2 is an insulin-regulated suppressor of hepatic gluconeogenesis. Cell Metab. 2010 Jan; 11(1):23-34. PMID: 20074525; PMCID: PMC2807620.
    12. Cheng Z, Guo S, Copps K, Dong X, Kollipara R, Rodgers J, Depinho RA, Puigserver P, White MF. Foxo1 integrates insulin signaling with mitochondrial function in the liver. Nat Med. 2009 Nov; 15(11):1307-11. PMID: 19838201; PMCID: PMC3994712.
    13. Rodgers J, Puigserver P. Insulin resistance: beta-arrestin development. Cell Res. 2009 Mar; 19(3):275-6. PMID: 19252509.
      View in: PubMed
    14. Housley MP, Udeshi ND, Rodgers J, Shabanowitz J, Puigserver P, Hunt DF, Hart GW. A PGC-1alpha-O-GlcNAc transferase complex regulates FoxO transcription factor activity in response to glucose. J Biol Chem. 2009 Feb 20; 284(8):5148-57. PMID: 19103600; PMCID: PMC2643526.
    15. Housley MP, Rodgers J, Udeshi ND, Kelly TJ, Shabanowitz J, Hunt DF, Puigserver P, Hart GW. O-GlcNAc regulates FoxO activation in response to glucose. J Biol Chem. 2008 Jun 13; 283(24):16283-92. PMID: 18420577; PMCID: PMC2423255.
    16. Cunningham JT, Rodgers J, Arlow DH, Vazquez F, Mootha VK, Puigserver P. mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Nature. 2007 Nov 29; 450(7170):736-40. PMID: 18046414.
      View in: PubMed
    17. Rodgers J, Lerin C, Gerhart-Hines Z, Puigserver P. Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways. FEBS Lett. 2008 Jan 09; 582(1):46-53. PMID: 18036349; PMCID: PMC2275806.
    18. Rodgers J, Puigserver P. Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1. Proc Natl Acad Sci U S A. 2007 Jul 31; 104(31):12861-6. PMID: 17646659; PMCID: PMC1937557.
    19. Kim D, Nguyen MD, Dobbin MM, Fischer A, Sananbenesi F, Rodgers J, Delalle I, Baur JA, Sui G, Armour SM, Puigserver P, Sinclair DA, Tsai LH. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. EMBO J. 2007 Jul 11; 26(13):3169-79. PMID: 17581637; PMCID: PMC1914106.
    20. Gerhart-Hines Z, Rodgers J, Bare O, Lerin C, Kim SH, Mostoslavsky R, Alt FW, Wu Z, Puigserver P. Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J. 2007 Apr 04; 26(7):1913-23. PMID: 17347648; PMCID: PMC1847661.
    21. Rodgers J, Puigserver P. Receptor feasts on sugar and cholesterol. Nat Med. 2007 Feb; 13(2):128-9. PMID: 17290267.
      View in: PubMed
    22. Cha SH, Rodgers J, Puigserver P, Chohnan S, Lane MD. Hypothalamic malonyl-CoA triggers mitochondrial biogenesis and oxidative gene expression in skeletal muscle: Role of PGC-1alpha. Proc Natl Acad Sci U S A. 2006 Oct 17; 103(42):15410-5. PMID: 17030788; PMCID: PMC1622837.
    23. Qin W, Yang T, Ho L, Zhao Z, Wang J, Chen L, Zhao W, Thiyagarajan M, MacGrogan D, Rodgers J, Puigserver P, Sadoshima J, Deng H, Pedrini S, Gandy S, Sauve AA, Pasinetti GM. Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction. J Biol Chem. 2006 Aug 04; 281(31):21745-54. PMID: 16751189.
      View in: PubMed
    24. Lerin C, Rodgers J, Kalume DE, Kim SH, Pandey A, Puigserver P. GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha. Cell Metab. 2006 Jun; 3(6):429-38. PMID: 16753578.
      View in: PubMed
    25. Rodgers J, Puigserver P. Certainly can't live without this: SIRT6. Cell Metab. 2006 Feb; 3(2):77-8. PMID: 16459306.
      View in: PubMed
    26. Puigserver P, Rodgers J. Foxa2, a novel transcriptional regulator of insulin sensitivity. Nat Med. 2006 Jan; 12(1):38-9. PMID: 16397559.
      View in: PubMed
    27. Rodgers J, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature. 2005 Mar 03; 434(7029):113-8. PMID: 15744310.
      View in: PubMed
    28. Vercoutere WA, Winters-Hilt S, DeGuzman VS, Deamer D, Ridino SE, Rodgers J, Olsen HE, Marziali A, Akeson M. Discrimination among individual Watson-Crick base pairs at the termini of single DNA hairpin molecules. Nucleic Acids Res. 2003 Feb 15; 31(4):1311-8. PMID: 12582251; PMCID: PMC150236.
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