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    John Traian Nicoloff, MD

    TitleProfessor of Medicine
    SchoolKeck School of Medicine of USC
    DepartmentMedicine
    AddressIRD 620
    Off Campus
    Los Angeles California 90089-9520
    Phone+1 626 993 2810
    vCardDownload vCard
      Other Positions
      TitleBernard J. Hanley Chair in Medicine


      Collapse Overview 
      Collapse Overview
      Dr. Nicoloff's current research includes hormonal factors regulating human pituitary TSH release, mechanism of nonsuppressible thyroxine secretion, alternate routes of T4 and T3 metabolism, and significance of circulating serum thyroglobulin in the management of neoplastic and other thyroid disease states.

      Dr. Nicoloff earned his medical degree from University of California, Los Angeles. Following his residency, he went on to complete a Metabolism Fellowship at University of Washington- Kings County Hospital.


      Collapse Biography 
      Collapse Awards and Honors
      Harper Foundation1955  - 1957Scholarship
      Lederle Laboratories1956Graduate Scholar
      Nathan and Zora Zolen1958Medical Scholarship
      American Thyroid Association1984Paul Starr Award
      American Thyroid Association2004Distinguished Service Award
      American Thyroid Association2006Thyroid Pathophysiology Medal

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Angell TE, Lechner MG, Nguyen CT, Salvato VL, Nicoloff J, LoPresti JS. Clinical features and hospital outcomes in thyroid storm: a retrospective cohort study. J Clin Endocrinol Metab. 2015 Feb; 100(2):451-9. PMID: 25343237.
        View in: PubMed
      2. Angell TE, Spencer CA, Rubino BD, Nicoloff J, LoPresti JS. In search of an unstimulated thyroglobulin baseline value in low-risk papillary thyroid carcinoma patients not receiving radioactive iodine ablation. Thyroid. 2014 Jul; 24(7):1127-33. PMID: 24697314.
        View in: PubMed
      3. Spencer C, Fatemi S, Singer P, Nicoloff J, Lopresti J. Serum Basal thyroglobulin measured by a second-generation assay correlates with the recombinant human thyrotropin-stimulated thyroglobulin response in patients treated for differentiated thyroid cancer. Thyroid. 2010 Jun; 20(6):587-95. PMID: 20470203.
        View in: PubMed
      4. Fatemi S, Bedri J, Nicoloff J. Encephalopathy associated with Hashimoto's thyroiditis: use of serum immunoglobulin G as a marker of disease activity. Thyroid. 2003 Feb; 13(2):227-8. PMID: 12699601.
        View in: PubMed
      5. Ringold DA, Nicoloff J, Kesler M, Davis H, Hamilton A, Mack T. Further evidence for a strong genetic influence on the development of autoimmune thyroid disease: the California twin study. Thyroid. 2002 Aug; 12(8):647-53. PMID: 12225632.
        View in: PubMed
      6. Spencer CA, LoPresti JS, Fatemi S, Nicoloff J. Detection of residual and recurrent differentiated thyroid carcinoma by serum thyroglobulin measurement. Thyroid. 1999 May; 9(5):435-41. PMID: 10365673.
        View in: PubMed
      7. Spencer CA, Takeuchi M, Kazarosyan M, Wang CC, Guttler RB, Singer PA, Fatemi S, LoPresti JS, Nicoloff J. Serum thyroglobulin autoantibodies: prevalence, influence on serum thyroglobulin measurement, and prognostic significance in patients with differentiated thyroid carcinoma. J Clin Endocrinol Metab. 1998 Apr; 83(4):1121-7. PMID: 9543128.
        View in: PubMed
      8. Ortega AE, Peters JH, Incarbone R, Estrada L, Ehsan A, Kwan Y, Spencer CJ, Moore-Jeffries E, Kuchta K, Nicoloff J. A prospective randomized comparison of the metabolic and stress hormonal responses of laparoscopic and open cholecystectomy. J Am Coll Surg. 1996 Sep; 183(3):249-56. PMID: 8784319.
        View in: PubMed
      9. Spencer CA, LoPresti JS, Nicoloff J, Dlott R, Schwarzbein D. Multiphasic thyrotropin responses to thyroid hormone administration in man. J Clin Endocrinol Metab. 1995 Mar; 80(3):854-9. PMID: 7883842.
        View in: PubMed
      10. LoPresti JS, Nicoloff J. 3,5,3'-Triiodothyronine (T3) sulfate: a major metabolite in T3 metabolism in man. J Clin Endocrinol Metab. 1994 Mar; 78(3):688-92. PMID: 8126143.
        View in: PubMed
      11. Nicoloff J, LoPresti JS. Myxedema coma. A form of decompensated hypothyroidism. Endocrinol Metab Clin North Am. 1993 Jun; 22(2):279-90. PMID: 8325287.
        View in: PubMed
      12. Spencer CA, Schwarzbein D, Guttler RB, LoPresti JS, Nicoloff J. Thyrotropin (TSH)-releasing hormone stimulation test responses employing third and fourth generation TSH assays. J Clin Endocrinol Metab. 1993 Feb; 76(2):494-8. PMID: 8432796.
        View in: PubMed
      13. Nicoloff J, Spencer CA. Non-thyrotropin-dependent thyroid secretion. J Clin Endocrinol Metab. 1992 Aug; 75(2):343. PMID: 1639932.
        View in: PubMed
      14. Nicoloff J, Spencer CA. Integration of thyroid hormones with hypothalamic factors on pituitary TSH secretion. Acta Med Austriaca. 1992; 19 Suppl 1:68-71. PMID: 1519458.
        View in: PubMed
      15. LoPresti JS, Mizuno L, Nimalysuria A, Anderson KP, Spencer CA, Nicoloff J. Characteristics of 3,5,3'-triiodothyronine sulfate metabolism in euthyroid man. J Clin Endocrinol Metab. 1991 Oct; 73(4):703-9. PMID: 1890147.
        View in: PubMed
      16. LoPresti JS, Gray D, Nicoloff J. Influence of fasting and refeeding on 3,3',5'-triiodothyronine metabolism in man. J Clin Endocrinol Metab. 1991 Jan; 72(1):130-6. PMID: 1986011.
        View in: PubMed
      17. Nicoloff J, Spencer CA. Clinical review 12: The use and misuse of the sensitive thyrotropin assays. J Clin Endocrinol Metab. 1990 Sep; 71(3):553-8. PMID: 2203796.
        View in: PubMed
      18. LoPresti JS, Anderson KP, Nicoloff J. Does a hidden pool of reverse triiodothyronine (rT3) production contribute to total thyroxine (T4) disposal in high T4 states in man. J Clin Endocrinol Metab. 1990 May; 70(5):1479-84. PMID: 2335581.
        View in: PubMed
      19. Spencer CA, LoPresti JS, Patel A, Guttler RB, Eigen A, Shen D, Gray D, Nicoloff J. Applications of a new chemiluminometric thyrotropin assay to subnormal measurement. J Clin Endocrinol Metab. 1990 Feb; 70(2):453-60. PMID: 2105333.
        View in: PubMed
      20. Fried JC, LoPresti JS, Micon M, Bauer M, Tuchschmidt JA, Nicoloff J. Serum triiodothyronine values. Prognostic indicators of acute mortality due to Pneumocystis carinii pneumonia associated with the acquired immunodeficiency syndrome. Arch Intern Med. 1990 Feb; 150(2):406-9. PMID: 2302016.
        View in: PubMed
      21. LoPresti JS, Eigen A, Kaptein E, Anderson KP, Spencer CA, Nicoloff J. Alterations in 3,3'5'-triiodothyronine metabolism in response to propylthiouracil, dexamethasone, and thyroxine administration in man. J Clin Invest. 1989 Nov; 84(5):1650-6. PMID: 2808705.
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      22. LoPresti JS, Fried JC, Spencer CA, Nicoloff J. Unique alterations of thyroid hormone indices in the acquired immunodeficiency syndrome (AIDS) Ann Intern Med. 1989 Jun 15; 110(12):970-5. PMID: 2567143.
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      23. Gray DS, Takahashi M, Fisler JS, LoPresti J, Nicoloff J, Bray GA. Effect of carbohydrate refeeding on free fatty acids after a fast in obese diabetic and obese non-diabetic females. Metabolism. 1989 Mar; 38(3):208-14. PMID: 2645502.
        View in: PubMed
      24. Silberman H, Eisenberg D, Ryan J, Shofler R, Niland J, Kaptein E, Nicoloff J, Spencer C. The relation of thyroid indices in the critically ill patient to prognosis and nutritional factors. Surg Gynecol Obstet. 1988 Mar; 166(3):223-8. PMID: 3344451.
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      25. Kaptein EM, Kaptein JS, Chang EI, Egodage PM, Nicoloff J, Massry SG. Thyroxine transfer and distribution in critical nonthyroidal illnesses, chronic renal failure, and chronic ethanol abuse. J Clin Endocrinol Metab. 1987 Oct; 65(4):606-16. PMID: 3116027.
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      26. Cashin-Hemphill L, Spencer CA, Nicoloff J, Blankenhorn DH, Nessim SA, Chin HP, Lee NA. Alterations in serum thyroid hormonal indices with colestipol-niacin therapy. Ann Intern Med. 1987 Sep; 107(3):324-9. PMID: 3113309.
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      27. Spencer C, Eigen A, Shen D, Duda M, Qualls S, Weiss S, Nicoloff J. Specificity of sensitive assays of thyrotropin (TSH) used to screen for thyroid disease in hospitalized patients. Clin Chem. 1987 Aug; 33(8):1391-6. PMID: 3301067.
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      28. Spencer CA, Lai-Rosenfeld AO, Guttler RB, LoPresti J, Marcus AO, Nimalasuriya A, Eigen A, Doss RC, Green BJ, Nicoloff J. Thyrotropin secretion in thyrotoxic and thyroxine-treated patients: assessment by a sensitive immunoenzymometric assay. J Clin Endocrinol Metab. 1986 Aug; 63(2):349-55. PMID: 3088021.
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      29. Penny R, Sims ME, Campbell WG, Spencer CA, Nicoloff J. Thyroid indices in arterial and venous cord blood: significantly greater levels of reverse triidothyronine in venous blood than in arterial blood. Metabolism. 1986 Jul; 35(7):645-8. PMID: 3724456.
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      30. Nimalasuriya A, Spencer CA, Lin SC, Tse JK, Nicoloff J. Studies on the diurnal pattern of serum 3,5,3'-triiodothyronine. J Clin Endocrinol Metab. 1986 Jan; 62(1):153-8. PMID: 3940263.
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      31. Spencer CA, Platler BW, Nicoloff J. The effect of [125I]thyroglobulin tracer heterogeneity on serum Tg RIA measurement. Clin Chim Acta. 1985 Dec 13; 153(2):105-15. PMID: 4064340.
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      32. Spencer CA, Platler BW, Guttler RB, Nicoloff J. Heterogeneity of 125I-labeled human thyroglobulin preparations. Clin Chim Acta. 1985 Sep 30; 151(2):121-32. PMID: 4042376.
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      33. Penny R, Spencer CA, Frasier SD, Nicoloff J. Cord serum thyroid-stimulating hormone and thyroglobulin levels decline with increasing birth weight in newborns. J Clin Endocrinol Metab. 1984 Nov; 59(5):979-85. PMID: 6480816.
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      34. Lum SM, Nicoloff J, Spencer CA, Kaptein EM. Peripheral tissue mechanism for maintenance of serum triiodothyronine values in a thyroxine-deficient state in man. J Clin Invest. 1984 Feb; 73(2):570-5. PMID: 6699177.
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      35. Nicoloff J, Lum SM, Spencer CA, Morris R. Peripheral autoregulation of thyroxine to triiodothyronine conversion in man. Horm Metab Res Suppl. 1984; 14:74-9. PMID: 6595193.
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      36. Spencer CA, Lum SM, Wilber JF, Kaptein EM, Nicoloff J. Dynamics of serum thyrotropin and thyroid hormone changes in fasting. J Clin Endocrinol Metab. 1983 May; 56(5):883-8. PMID: 6403568.
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      37. Penny R, Spencer CA, Frasier SD, Nicoloff J. Thyroid-stimulating hormone and thyroglobulin levels decrease with chronological age in children and adolescents. J Clin Endocrinol Metab. 1983 Jan; 56(1):177-80. PMID: 6847868.
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      38. LoPresti JS, Warren DW, Kaptein EM, Croxson MS, Nicoloff J. Urinary immunoprecipitation method for estimation of thyroxine to triiodothyronine conversion in altered thyroid states. J Clin Endocrinol Metab. 1982 Oct; 55(4):666-70. PMID: 7050140.
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      39. Alexander CM, Kaptein EM, Lum SM, Spencer CA, Kumar D, Nicoloff J. Pattern of recovery of thyroid hormone indices associated with treatment of diabetes mellitus. J Clin Endocrinol Metab. 1982 Feb; 54(2):362-6. PMID: 6798065.
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      40. Warren DW, LoPresti JS, Nicoloff J. A new method for measurement of the conversion ratio of thyroxine to triiodothyronine in euthyroid man. J Clin Endocrinol Metab. 1981 Dec; 53(6):1218-22. PMID: 7298801.
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      41. Kaptein EM, Grieb DA, Spencer CA, Wheeler WS, Nicoloff J. Thyroxine metabolism in the low thyroxine state of critical nonthyroidal illnesses. J Clin Endocrinol Metab. 1981 Oct; 53(4):764-71. PMID: 6793608.
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      42. Kaptein EM, MacIntyre SS, Weiner JM, Spencer CA, Nicoloff J. Free thyroxine estimates in nonthyroidal illness: comparison of eight methods. J Clin Endocrinol Metab. 1981 Jun; 52(6):1073-7. PMID: 6164687.
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      43. Nicoloff J, Warren DW, Mizuno L, Spencer CA, Kaptein EM. Hepatic thyroxine (T4) uptake as a mechanism for regulation of triiodothyronine (T3) generation in rat liver slices. Life Sci. 1981 Apr 13-20; 28(15-16):1713-8. PMID: 7242256.
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      44. Spencer CA, Nicoloff J. Improved radioimmunoassay for human TSH. Clin Chim Acta. 1980 Dec 22; 108(3):415-24. PMID: 7471472.
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      45. Spencer CA, Greenstadt MA, Wheeler WS, Kletzky OA, Nicoloff J. The influence of long-term low dose thyrotropin-releasing hormone infusions on serum thyrotropin and prolactin concentrations in man. J Clin Endocrinol Metab. 1980 Oct; 51(4):771-5. PMID: 6774994.
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      46. Kaptein EM, Kletzky OA, Spencer CA, Nicoloff J. Effects of prolonged dopamine infusion on anterior pituitary function in normal males. J Clin Endocrinol Metab. 1980 Sep; 51(3):488-91. PMID: 6773976.
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      47. Kaptein EM, Spencer CA, Kamiel MB, Nicoloff J. Prolonged dopamine administration and thyroid hormone economy in normal and critically ill subjects. J Clin Endocrinol Metab. 1980 Aug; 51(2):387-93. PMID: 7400302.
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      48. Singer PA, Nicoloff J, Stein RB, Jaramillo J. Transient TRH deficiency after prolonged thyroid hormone therapy. J Clin Endocrinol Metab. 1978 Sep; 47(3):512-8. PMID: 122410.
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      49. Singer PA, Mestman JH, Manning PR, Nicoloff J. Hypothalamic-hypothyroidism secondary to Sheehan's syndrome. West J Med. 1974 May; 120(5):416-8. PMID: 4839489.
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      50. Singer PA, Nicoloff J. Assessment of thyrotropin-releasing hormone and thyrotropin reserve in man. J Clin Invest. 1973 May; 52(5):1099-107. PMID: 4633675.
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      51. Singer PA, Nicoloff J. Estimation of the triodothyronine secretion rate in euthyroid man. J Clin Endocrinol Metab. 1972 Jul; 35(1):82-9. PMID: 5032518.
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      52. Singer PA, Nicoloff J. Metabolic clearance rates of diiodotyrosine in man. J Clin Endocrinol Metab. 1972 Apr; 34(4):666-70. PMID: 4111067.
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