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James David Adams, PhD

TitleAssociate Professor
InstitutionUniversity of Southern California
DepartmentPharmacology and Pharmaceutical Sciences
AddressPSC 716
Health Sciences Campus
Los Angeles CA 90089-9121
Phone+1 323 442 1362
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    Collapse Overview
    I am interested in California medicinal plants and learned for 14 years from a Chumash Healer how to use these plants. Having recently discovered new pharmacologically interesting compounds in three different California plants, I am now in the process of further characterizing these compounds. Future work will involve testing these compounds and plant medicines in animal models and clinical trials to find out if they have important medicinal properties. I am interested in pain control, stroke therapy and eczema therapy with California medicinal plants.

    Biography
    Dr. Adams received his PhD from UC San Francisco in 1981 in Pharmacology and Toxicology. His postdoctoral experience was at Baylor College of Medicine in Houston, Texas and the National Institutes of Health in Bethesda, Maryland. He served as a research assistant professor at Washington State University before coming to USC School of Pharmacy in 1987.

    Dr. Adams has worked on cytochrome P450 metabolism of ketamine, phencyclidine and polycyclic aromatic hydrocarbons in the laboratories of Neal Castagnoli, Anthony Trevor and Don Jerina. Under the direction of Jerry Mitchell, Dr. Adams developed a widely used assay for GSH and GSSG and showed how GSH and GSSG levels change during oxidative stress in many organs.

    In collaboration with Enrique Cadenas, Dr. Adams discovered the mechanism of redox cycling of MPTP, the toxic agent that can produce Parkinson's disease in humans and animals. In collaboration with Jean Shih, Dr. Adams showed that MAO knockout mice are resistant to MPTP toxicity.

    Lori Klaidman and Dr. Adams developed a widely used assay for NADPH, NADP, NADH and NAD. In collaboration with Pak Chan at Stanford, Dr. Adams' lab demonstrated that DNA is a primary and early target of oxygen radicals during stroke and Parkinson's disease. DNA damage leads to apoptosis and necrosis. His lab demonstrated that DNA damage can be mitigated by treatment with nicotinamide, a precursor for NAD.

    Dr. Adams's lab holds the patent for use of nicotinamide (vitamin B3) to treat stroke and other forms of neurodegeneration. He has written over 160 publications, six books and 60 abstracts.

    Dr. Adams is currently working on California medicinal plants. He was trained for many years by Chumash people and is a Traditional Healer. He has written many books and articles on Traditional Healing.


    Collapse Research 
    Collapse Research Activities and Funding
    NEW MODEL FOR BRAIN OXIDATIVE STRESS
    NIH/NINDS R01NS029442Mar 1, 1992 - Feb 28, 1996
    Role: Principal Investigator
    MECHANISM OF INDUCTION OF PARKINSONIAN SYNDROME BY MPTP
    NIH/NINDS R01NS023515Jul 1, 1987 - Jun 30, 1991
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Coricello A, Adams J, Lien E, Nguyen C, Perri F, Williams TJ, Aiello F. A Walk in Nature. Sesquiterpene Lactones as Multi-Target Agents Involved in Inflammatory Pathways. Curr Med Chem. 2018 Jul 18. PMID: 30027844.
      View in: PubMed
    2. Adams J. Does the World Need Plant Medicines? Medicines (Basel). 2018 Apr 23; 5(2). PMID: 29690579.
      View in: PubMed
    3. Adams J. The Effects of Yin, Yang and Qi in the Skin on Pain. Medicines (Basel). 2016 Jan 29; 3(1). PMID: 28930115.
      View in: PubMed
    4. Chen CY, Adams J, Hou T, Litscher G. When modern technology meets ancient traditional chinese medicine. Evid Based Complement Alternat Med. 2015; 2015:156581. PMID: 25788960; PMCID: PMC4350617.
    5. Adams J. The Use of California Sagebrush (Artemisia californica) Liniment to Control Pain. Pharmaceuticals (Basel). 2012 Sep 27; 5(10):1045-53. PMID: 24281255; PMCID: PMC3816656.
    6. Adams J. Chemical interactions with pyramidal neurons in layer 5 of the cerebral cortex: control of pain and anxiety. Curr Med Chem. 2009; 16(27):3476-9. PMID: 19799545.
      View in: PubMed
    7. Adams J. Alzheimer's disease, ceramide, visfatin and NAD. CNS Neurol Disord Drug Targets. 2008 Dec; 7(6):492-8. PMID: 19128206.
      View in: PubMed
    8. Adams J, Garcia C, Lien EJ. A comparison of chinese and american Indian (chumash) medicine. Evid Based Complement Alternat Med. 2010 Jun; 7(2):219-25. PMID: 18955312.
      View in: PubMed
    9. Adams J, Wang R, Yang J, Lien EJ. Preclinical and clinical examinations of Salvia miltiorrhiza and its tanshinones in ischemic conditions. Chin Med. 2006 Nov 23; 1:3. PMID: 17302964; PMCID: PMC1761145.
    10. Adams J, Garcia C. Women's health among the Chumash. Evid Based Complement Alternat Med. 2006 Mar; 3(1):125-31. PMID: 16550233; PMCID: PMC1375244.
    11. Adams J, Garcia C. Spirit, mind and body in Chumash healing. Evid Based Complement Alternat Med. 2005 Dec; 2(4):459-63. PMID: 16322802; PMCID: PMC1297503.
    12. Yang J, He L, Wang J, Adams J. Early administration of nicotinamide prevents learning and memory impairment in mice induced by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine. Pharmacol Biochem Behav. 2004 May; 78(1):179-83. PMID: 15159148.
      View in: PubMed
    13. Klaidman LK, Yang J, Chang ML, Adams J. Recent developments on the role of mitochondria in poly(ADP-ribose) polymerase inhibition. Curr Med Chem. 2003 Dec; 10(24):2669-78. PMID: 14529457.
      View in: PubMed
    14. Klaidman L, Morales M, Kem S, Yang J, Chang ML, Adams J. Nicotinamide offers multiple protective mechanisms in stroke as a precursor for NAD+, as a PARP inhibitor and by partial restoration of mitochondrial function. Pharmacology. 2003 Nov; 69(3):150-7. PMID: 14512702.
      View in: PubMed
    15. Klaidman LK, Adams J, Cross R, Pazdernik TL, Samson F. Alterations in brain glutathione homeostasis induced by the nerve gas soman. Neurotox Res. 2003; 5(3):177-82. PMID: 12835122.
      View in: PubMed
    16. Yang J, Klaidman LK, Nalbandian A, Oliver J, Chang ML, Chan PH, Adams J. The effects of nicotinamide on energy metabolism following transient focal cerebral ischemia in Wistar rats. Neurosci Lett. 2002 Nov 22; 333(2):91-4. PMID: 12419488.
      View in: PubMed
    17. Adams J, Yang J, Mishra LC, Singh BB. Effects of ashwagandha in a rat model of stroke. Altern Ther Health Med. 2002 Sep-Oct; 8(5):18-9. PMID: 12233797.
      View in: PubMed
    18. Adams J, Klaidman LK, Mishra L, Singh BB. Effects of guggul in a rat model of stroke. Altern Ther Health Med. 2002 Jul-Aug; 8(4):20-1. PMID: 12126167.
      View in: PubMed
    19. Chang ML, Yang J, Kem S, Klaidman L, Sugawara T, Chan PH, Adams J. Nicotinamide and ketamine reduce infarct volume and DNA fragmentation in rats after brain ischemia and reperfusion. Neurosci Lett. 2002 Apr 12; 322(3):137-40. PMID: 11897157.
      View in: PubMed
    20. Adams J, Klaidman LK, Chang ML, Yang J. Brain oxidative stress--analytical chemistry and thermodynamics of glutathione and NADPH. Curr Top Med Chem. 2001 Dec; 1(6):473-82. PMID: 11895124.
      View in: PubMed
    21. Adams J, Chang ML, Klaidman L. Parkinson's disease--redox mechanisms. Curr Med Chem. 2001 Jun; 8(7):809-14. PMID: 11375751.
      View in: PubMed
    22. Klaidman LK, Mukherjee SK, Adams J. Oxidative changes in brain pyridine nucleotides and neuroprotection using nicotinamide. Biochim Biophys Acta. 2001 Feb 16; 1525(1-2):136-48. PMID: 11342263.
      View in: PubMed
    23. Adams J, Sayer JM, Chadha A, Shirai N, Lehr RE, Kumar S, Jerina DM. The proximate carcinogen trans-3,4-dihydroxy-3,4-dihydro-dibenz[c,h]acridine is oxidized stereoselectively and regioselectively by cytochrome 1A1, epoxide hydrolase and hepatic microsomes from 3-methylcholanthrene-treated rats. Chem Biol Interact. 1999 Sep 30; 122(2):117-35. PMID: 10528997.
      View in: PubMed
    24. Adams J, Klaidman LK, Ribeiro P. Tyrosine hydroxylase: mechanisms of oxygen radical formation. Redox Rep. 1997 Oct-Dec; 3(5-6):273-9. PMID: 9754325.
      View in: PubMed
    25. Mukherjee SK, Adams J. The effects of aging and neurodegeneration on apoptosis-associated DNA fragmentation and the benefits of nicotinamide. Mol Chem Neuropathol. 1997 Sep-Dec; 32(1-3):59-74. PMID: 9437658.
      View in: PubMed
    26. Mukherjee SK, Klaidman LK, Yasharel R, Adams J. Increased brain NAD prevents neuronal apoptosis in vivo. Eur J Pharmacol. 1997 Jul 02; 330(1):27-34. PMID: 9228411.
      View in: PubMed
    27. Chang ML, Adams J. Pharmacokinetics of intracerebroventricular tBuOOH in young adult and mature mice. Mol Chem Neuropathol. 1997 May; 31(1):73-84. PMID: 9271007.
      View in: PubMed
    28. Chang ML, Klaidman LK, Adams J. The effects of oxidative stress on in vivo brain GSH turnover in young and mature mice. Mol Chem Neuropathol. 1997 Apr; 30(3):187-97. PMID: 9165485.
      View in: PubMed
    29. Martel CL, Mackic JB, Adams J, McComb JG, Weiss MH, Zlokovic BV. Transport of dopamine at the blood-brain barrier of the guinea pig: inhibition by psychotropic drugs and nicotine. Pharm Res. 1996 Feb; 13(2):290-5. PMID: 8932451.
      View in: PubMed
    30. Chang ML, Klaidman L, Adams J. Age-dependent effects of t-BuOOH on glutathione disulfide reductase, glutathione peroxidase, and malondialdehyde in the brain. Mol Chem Neuropathol. 1995 Oct; 26(2):95-106. PMID: 8573245.
      View in: PubMed
    31. Klaidman LK, Leung AC, Adams J. High-performance liquid chromatography analysis of oxidized and reduced pyridine dinucleotides in specific brain regions. Anal Biochem. 1995 Jul 01; 228(2):312-7. PMID: 8572312.
      View in: PubMed
    32. Adams J, Yagi H, Levin W, Jerina DM. Stereo-selectivity and regio-selectivity in the metabolism of 7,8-dihydrobenzo[a]pyrene by cytochrome P450, epoxide hydrolase and hepatic microsomes from 3-methylcholanthrene-treated rats. Chem Biol Interact. 1995 Mar 30; 95(1-2):57-77. PMID: 7697754.
      View in: PubMed
    33. Mukherjee SK, Yasharel R, Klaidman LK, Hutchin TP, Adams J. Apoptosis and DNA fragmentation as induced by tertiary butylhydroperoxide in the brain. Brain Res Bull. 1995; 38(6):595-604. PMID: 8590084.
      View in: PubMed
    34. Adams J, Klaidman LK, Huang YM, Cheng JJ, Wang ZJ, Nguyen M, Kn├╝sel B, Kuda A. The neuropathology of intracerebroventricular t-butylhydroperoxide. Mol Chem Neuropathol. 1994 Jun; 22(2):123-42. PMID: 7916771.
      View in: PubMed
    35. Adams J, Wang B. Vitamin E uptake into the brain and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity. J Cereb Blood Flow Metab. 1994 Mar; 14(2):362-3. PMID: 8113333.
      View in: PubMed
    36. Adams J, Wang B, Klaidman LK, LeBel CP, Odunze IN, Shah D. New aspects of brain oxidative stress induced by tert-butylhydroperoxide. Free Radic Biol Med. 1993 Aug; 15(2):195-202. PMID: 8375692.
      View in: PubMed
    37. Adams J, Klaidman LK, Leung AC. MPP+ and MPDP+ induced oxygen radical formation with mitochondrial enzymes. Free Radic Biol Med. 1993 Aug; 15(2):181-6. PMID: 8397143.
      View in: PubMed
    38. Adams J, Klaidman LK. Acrolein-induced oxygen radical formation. Free Radic Biol Med. 1993 Aug; 15(2):187-93. PMID: 8397144.
      View in: PubMed
    39. Klaidman LK, Adams J, Leung AC, Kim SS, Cadenas E. Redox cycling of MPP+: evidence for a new mechanism involving hydride transfer with xanthine oxidase, aldehyde dehydrogenase, and lipoamide dehydrogenase. Free Radic Biol Med. 1993 Aug; 15(2):169-79. PMID: 8397142.
      View in: PubMed
    40. Mattia CJ, Adams J, Bondy SC. Free radical induction in the brain and liver by products of toluene catabolism. Biochem Pharmacol. 1993 Jul 06; 46(1):103-10. PMID: 8394073.
      View in: PubMed
    41. Klaidman LK, Tombran-Tink J, Adams J, Johnson LV. Effects of medium conditioned by retinal pigmented epithelial cells on neurotransmitter phenotype in retinoblastoma cells. Cancer Lett. 1993 Feb; 68(2-3):207-13. PMID: 8443794.
      View in: PubMed
    42. Adams J, Klaidman LK, Odunze IN, Shen HC, Miller CA. Alzheimer's and Parkinson's disease. Brain levels of glutathione, glutathione disulfide, and vitamin E. Mol Chem Neuropathol. 1991 Jun; 14(3):213-26. PMID: 1958264.
      View in: PubMed
    43. Adams J, Odunze IN. Biochemical mechanisms of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity. Could oxidative stress be involved in the brain? Biochem Pharmacol. 1991 Apr 15; 41(8):1099-105. PMID: 2009088.
      View in: PubMed
    44. Adams J, Klaidman LK, Odunze IN, Johannessen JN. Effects of MPTP on the cerebrovasculature. Int J Dev Neurosci. 1991; 9(2):155-9. PMID: 2058417.
      View in: PubMed
    45. Adams J, Odunze IN. Oxygen free radicals and Parkinson's disease. Free Radic Biol Med. 1991; 10(2):161-9. PMID: 2016074.
      View in: PubMed
    46. Odunze IN, Klaidman LK, Adams J. MPTP toxicity in the mouse brain and vitamin E. Neurosci Lett. 1990 Jan 22; 108(3):346-9. PMID: 2304652.
      View in: PubMed
    47. Adams J, Odunze IN, Sevanian A. Induction by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine of lipid peroxidation in vivo in vitamin E deficient mice. Biochem Pharmacol. 1990 Jan 01; 39(1):R5-8. PMID: 2297351.
      View in: PubMed
    48. LeBel CP, Odunze IN, Adams J, Bondy SC. Perturbations in cerebral oxygen radical formation and membrane order following vitamin E deficiency. Biochem Biophys Res Commun. 1989 Sep 15; 163(2):860-6. PMID: 2783127.
      View in: PubMed
    49. Adams J, Kalivas PW, Miller CA. The acute histopathology of MPTP in the mouse CNS. Brain Res Bull. 1989 Jul-Aug; 23(1-2):1-17. PMID: 2804701.
      View in: PubMed
    50. Skiles GL, Adams J, Yost GS. Isolation and identification of 3-hydroxy-3-methyloxindole, the major murine metabolite of 3-methylindole. Chem Res Toxicol. 1989 Jul-Aug; 2(4):254-9. PMID: 2519781.
      View in: PubMed
    51. Huijzer JC, Adams J, Jaw JY, Yost GS. Inhibition of 3-methylindole bioactivation by the cytochrome P-450 suicide substrates 1-aminobenzotriazole and alpha-methylbenzylaminobenzotriazole. Drug Metab Dispos. 1989 Jan-Feb; 17(1):37-42. PMID: 2566467.
      View in: PubMed
    52. Adams J, Laegreid WW, Huijzer JC, Hayman C, Yost GS. Pathology and glutathione status in 3-methylindole-treated rodents. Res Commun Chem Pathol Pharmacol. 1988 Jun; 60(3):323-36. PMID: 3175331.
      View in: PubMed
    53. Adams J, Heins MC, Yost GS. 3-Methylindole inhibits lipid peroxidation. Biochem Biophys Res Commun. 1987 Nov 30; 149(1):73-8. PMID: 3689418.
      View in: PubMed
    54. Huijzer JC, Adams J, Yost GS. Decreased pneumotoxicity of deuterated 3-methylindole: bioactivation requires methyl C-H bond breakage. Toxicol Appl Pharmacol. 1987 Aug; 90(1):60-8. PMID: 3629592.
      View in: PubMed
    55. Adams J, Lauterburg BH, Mitchell JR. Plasma glutathione disulfide as an index of oxidant stress in vivo: effects of carbon tetrachloride, dimethylnitrosamine, nitrofurantoin, metronidazole, doxorubicin and diquat. Res Commun Chem Pathol Pharmacol. 1984 Dec; 46(3):401-10. PMID: 6515129.
      View in: PubMed
    56. Adams J, Lauterburg BH, Mitchell JR. Plasma glutathione and glutathione disulfide in the rat: regulation and response to oxidative stress. J Pharmacol Exp Ther. 1983 Dec; 227(3):749-54. PMID: 6655568.
      View in: PubMed
    57. Adams J, Woolf TF, Trevor AJ, Williams LR, Castagnoli N. Derivatization of chiral amines with (S,S)-N-trifluoroacetylproline anhydride for GC estimation of enantiomeric composition. J Pharm Sci. 1982 Jun; 71(6):658-61. PMID: 7097528.
      View in: PubMed
    58. Adams J, Baillie TA, Trevor AJ, Castagnoli N. Studies on the biotransformation of ketamine. 1-Identification of metabolites produced in vitro from rat liver microsomal preparations. Biomed Mass Spectrom. 1981 Nov; 8(11):527-38. PMID: 7317567.
      View in: PubMed
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