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    Jae U Jung, PhD

    TitleDistinguished Professor and Chair, Molecular Microbiology and Immunology
    SchoolKeck School of Medicine of USC
    DepartmentMolecular Microbiology and Immunology
    AddressHMR 401 2011 Zonal Avenue
    Health Sciences Campus
    Los Angeles California 90089
    Phone+1 323 442 1713
    Emailjaeujung@usc.edu
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      Other Positions
      TitleFletcher Jones Foundation Chair in Molecular Microbiology and Immunology


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      My laboratory is conducting different areas of research:

      Host and Virus Standoff: Co-existence of viruses with their hosts requires a balance between host immune responses and their evasion by viruses. To deal with the sophisticated host immune system, viruses have evolved a myriad of immune evasion mechanisms to avoid elimination by the host's immune response. Herpesvirus: Host immune responses, including cytotoxic T lymphocytes and Natural killer cells, play essential roles in the elimination of virus-infected cells. Additionally, interferon and lymphotoxin and their receptor pathways are critical to the early viral infection, ultimately kick-starting the innate and adaptive immune responses of the host defense. Finally, the host carries various intracellular restriction mechanisms to thwart the spread of pathogens. Gifted with large genetic capacity, herpesviruses encode a wider array of viral immune modulators to avoid these host innate and adaptive immune responses. Understanding herpesvirus-mediated immune evasion tactics is the primary goal of this avenue.

      Influenza Virus: The second avenue of this section is focused primarily on interferon (IFN)-mediated anti-virus immunity. Upon viral infection, the major defense mounted by the host immune system is activation of the IFN-mediated anti-viral innate immune pathway. In order to complete their life cycle, viruses that are obligatory intracellular parasites must modulate host IFN-mediated immune response. We study how the host recognizes viral infection with a specific focus on the RIG-I, TRIMs and IRF genes, and how influenza virus escapes host IFN-mediated anti-viral response with a specific focus on the Influenza virus NS1 gene. Genetically altered mice are used to demonstrate the in vivo roles of host and viral IFN regulatory genes.

      Virus-Induced Cancer: This section is focused on understanding the molecular mechanisms of lymphoproliferative diseases induced by the gamma-2 herpesviruses and on developing animal models for human diseases. The gamma 2 herpesviruses include murine herpesvirus 68 (MHV68), herpesvirus saimiri (HVS), and Kaposi's sarcoma associated herpesvirus (KSHV). KSHV is consistently associated with Kaposi's sarcoma, which is a multifocal vascular tumor of mixed cellular composition and is the most common tumor in patients with AIDS. Infection of New World primates with HVS results in rapidly progressing malignant T cell lymphomas. Finally, MHV68 provides a small animal model to study viral persistent infection. Biochemical and immunological analyses of individual viral genes in cell culture and experimental infection of mouse or primate with recombinant herpesviruses are used to define their roles in the onset of disease.

      Programmed Cell Death (PCD): Apoptosis has been a primary PCD mechanism to respond viral infection by participating in its own death. Autophagy (Greek, "to eat oneself") is a new, emerging cellular pathway in which subcellular membranes undergo dynamic morphological changes that lead to the degradation of cellular proteins, cytoplasmic organelles, and invading pathogens. Thus, apoptotic and autophagic PCDs are important innate safeguard mechanisms to protect the organism against harmful microbes and unwanted cancerous cells. Viruses, in turn, have evolved elaborate mechanisms to subvert apoptotic and autophagic processes. This avenue is to understand how host initiates apoptosis and autophagy responses upon viral infection and how virus escapes host intracellular PCD-mediated innate immune controls to establish persistent infection and pathogenesis.

      Acute Lymphoblastic Leukemia (ALL) and Prostate Cancer: We utilize genetically engineered mouse models and chemical inhibitors to investigate the molecular details of ALL and prostate cancer and to develop therapeutic strategies against these cancers.


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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Hwang SW, Kim D, Jung J, Lee HR. KSHV-encoded viral interferon regulatory factor 4 (vIRF4) interacts with IRF7 and inhibits interferon alpha production. Biochem Biophys Res Commun. 2017 Mar 22. PMID: 28342865.
        View in: PubMed
      2. Chen CL, Huang JY, Wang CH, Tahara SM, Zhou L, Kondo Y, Schechter J, Su L, Lai MM, Wakita T, Cosset FL, Jung J, Machida K. Hepatitis C virus has a genetically determined lymphotropism through co-receptor B7.2. Nat Commun. 2017 Jan 09; 8:13882. PMID: 28067225.
        View in: PubMed
      3. Lee HR, Choi UY, Hwang SW, Kim S, Jung J. Viral Inhibition of PRR-Mediated Innate Immune Response: Learning from KSHV Evasion Strategies. Mol Cells. 2016 Nov 18. PMID: 27871174.
        View in: PubMed
      4. Maazi H, Suzuki Y, Jung J, Akbari O. Reply. J Allergy Clin Immunol. 2016 Nov 12. PMID: 27847142.
        View in: PubMed
      5. Tan L, Zhang C, Dematos J, Kuang L, Jung J, Liang X. CD95 Signaling Inhibits B Cell Receptor-Mediated Gammaherpesvirus Replication in Apoptosis-Resistant B Lymphoma Cells. J Virol. 2016 Nov 01; 90(21):9782-9796. PMID: 27558422.
        View in: PubMed
      6. Seo GJ, Choi Y, Jung J. No TRIFling Matter on STING. Cell Host Microbe. 2016 Sep 14; 20(3):277-8. PMID: 27631696.
        View in: PubMed
      7. Toth Z, Papp B, Brulois K, Choi YJ, Gao SJ, Jung J. LANA-Mediated Recruitment of Host Polycomb Repressive Complexes onto the KSHV Genome during De Novo Infection. PLoS Pathog. 2016 Sep; 12(9):e1005878. PMID: 27606464.
        View in: PubMed
      8. Lee EY, Lee HC, Kim HK, Jang SY, Park SJ, Kim YH, Kim JH, Hwang J, Kim JH, Kim TH, Arif A, Kim SY, Choi YK, Lee C, Lee CH, Jung J, Fox PL, Kim S, Lee JS, Kim MH. Infection-specific phosphorylation of glutamyl-prolyl tRNA synthetase induces antiviral immunity. Nat Immunol. 2016 Sep 05. PMID: 27595231.
        View in: PubMed
      9. Liang Q, Luo Z, Zeng J, Chen W, Foo SS, Lee SA, Ge J, Wang S, Goldman SA, Zlokovic BV, Zhao Z, Jung J. Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy. Cell Stem Cell. 2016 Aug 9. PMID: 27524440.
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      10. Lee JH, Lee JH, Lee SH, Do SI, Cho SD, Forslund O, Inn KS, Lee JS, Deng FM, Melamed J, Jung J, Jeong JH. TPL2 Is an Oncogenic Driver in Keratocanthoma and Squamous Cell Carcinoma. Cancer Res. 2016 Nov 15; 76(22):6712-6722. PMID: 27503930.
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      11. Cheng F, He M, Jung J, Lu C, Gao SJ. Suppression of Kaposi's Sarcoma-Associated Herpesvirus Infection and Replication by 5'-AMP-Activated Protein Kinase. J Virol. 2016 Jul 15; 90(14):6515-25. PMID: 27147746.
        View in: PubMed
      12. Kim YR, Koh HJ, Kim JS, Yun JS, Jang K, Lee JY, Jung J, Yang CS. Peptide inhibition of p22phox and Rubicon interaction as a therapeutic strategy for septic shock. Biomaterials. 2016 Sep; 101:47-59. PMID: 27267627.
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      13. Zhu Y, Ramos da Silva S, He M, Liang Q, Lu C, Feng P, Jung J, Gao SJ. An Oncogenic Virus Promotes Cell Survival and Cellular Transformation by Suppressing Glycolysis. PLoS Pathog. 2016 May; 12(5):e1005648. PMID: 27187079.
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      14. Nicol SM, Sabbah S, Brulois KF, Jung J, Bell AI, Hislop AD. Primary B Lymphocytes Infected with Kaposi's Sarcoma-Associated Herpesvirus Can Be Expanded In Vitro and Are Recognized by LANA-Specific CD4+ T Cells. J Virol. 2016 Apr 15; 90(8):3849-59. PMID: 26819313.
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      15. Chen Z, Shojaee S, Buchner M, Geng H, Lee JW, Klemm L, Titz B, Graeber TG, Park E, Tan YX, Satterthwaite A, Paietta E, Hunger SP, Willman CL, Melnick A, Loh ML, Jung J, Coligan JE, Bolland S, Mak TW, Limnander A, Jumaa H, Reth M, Weiss A, Lowell CA, Müschen M. Corrigendum: Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. Nature. 2016 Jun 2; 534(7605):138. PMID: 26958840.
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      16. Lee MS, Yuan H, Jeon H, Zhu Y, Yoo S, Shi S, Krueger B, Renne R, Lu C, Jung J, Gao SJ. Human Mesenchymal Stem Cells of Diverse Origins Support Persistent Infection with Kaposi's Sarcoma-Associated Herpesvirus and Manifest Distinct Angiogenic, Invasive, and Transforming Phenotypes. MBio. 2016; 7(1). PMID: 26814175.
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      17. Choi SJ, Lee HC, Kim JH, Park SY, Kim TH, Lee WK, Jang DJ, Yoon JE, Choi YI, Kim S, Ma J, Kim CJ, Yao TP, Jung J, Lee JY, Lee JS. HDAC6 regulates cellular viral RNA sensing by deacetylation of RIG-I. EMBO J. 2016 Feb 15; 35(4):429-42. PMID: 26746851.
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      18. Stittrich AB, Ashworth J, Shi M, Robinson M, Mauldin D, Brunkow ME, Biswas S, Kim JM, Kwon KS, Jung J, Galas D, Serikawa K, Duerr RH, Guthery SL, Peschon J, Hood L, Roach JC, Glusman G. Genomic architecture of inflammatory bowel disease in five families with multiple affected individuals. Hum Genome Var. 2016; 3:15060. PMID: 27081563.
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      19. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016 Jan 2; 12(1):1-222. PMID: 26799652.
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      20. Bowman J, Rodgers MA, Shi M, Amatya R, Hostager B, Iwai K, Gao SJ, Jung J. Posttranslational Modification of HOIP Blocks Toll-Like Receptor 4-Mediated Linear-Ubiquitin-Chain Formation. MBio. 2015; 6(6). PMID: 26578682.
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      21. Suzuki Y, Maazi H, Sankaranarayanan I, Lam J, Khoo B, Soroosh P, Barbers RG, James Ou JH, Jung J, Akbari O. Lack of autophagy induces steroid-resistant airway inflammation. J Allergy Clin Immunol. 2015 Nov 14. PMID: 26589586.
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      22. Skeate JG, Porras TB, Woodham AW, Jang JK, Taylor JR, Brand HE, Kelly TJ, Jung J, Da Silva DM, Yuan W, Kast WM. Herpes Simplex Virus downregulation of secretory leukocyte protease inhibitor enhances Human Papillomavirus type 16 infection. J Gen Virol. 2015 Nov 10. PMID: 26555393.
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      23. Lee HR, Mitra J, Lee S, Gao SJ, Oh TK, Kim MH, Ha T, Jung J. Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 4 (vIRF4) Perturbs the G1-S Cell Cycle Progression via Deregulation of the cyclin D1 Gene. J Virol. 2015; 90(2):1139-43. PMID: 26491150.
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      24. Seo GJ, Yang A, Tan B, Kim S, Liang Q, Choi Y, Yuan W, Feng P, Park HS, Jung J. Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway. Cell Rep. 2015 Oct 13; 13(2):440-9. PMID: 26440888.
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      25. Jung J, Münz C. Immune control of oncogenic ?-herpesviruses. Curr Opin Virol. 2015 Oct; 14:79-86. PMID: 26372881.
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      26. Yoo YS, Park YY, Kim JH, Cho H, Kim SH, Lee HS, Kim TH, Sun Kim Y, Lee Y, Kim CJ, Jung J, Lee JS, Cho H. The mitochondrial ubiquitin ligase MARCH5 resolves MAVS aggregates during antiviral signalling. Nat Commun. 2015; 6:7910. PMID: 26246171.
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      27. Cheng F, Sawant TV, Lan K, Lu C, Jung J, Gao SJ. Screening of the Human Kinome Identifies MSK1/2-CREB1 as an Essential Pathway Mediating Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication during Primary Infection. J Virol. 2015 Sep 15; 89(18):9262-80. PMID: 26109721.
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      28. Sohn YS, Shin HC, Park WS, Ge J, Kim CH, Lee BL, Heo WD, Jung J, Rigden DJ, Oh BH. Lpg0393 of Legionella pneumophila Is a Guanine-Nucleotide Exchange Factor for Rab5, Rab21 and Rab22. PLoS One. 2015; 10(3):e0118683. PMID: 25821953.
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      29. Zhang J, He S, Wang Y, Brulois K, Lan K, Jung J, Feng P. Herpesviral G Protein-Coupled Receptors Activate NFAT to Induce Tumor Formation via Inhibiting the SERCA Calcium ATPase. PLoS Pathog. 2015 Mar; 11(3):e1004768. PMID: 25811856.
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      30. Brulois K, Wong LY, Lee HR, Sivadas P, Ensser A, Feng P, Gao SJ, Toth Z, Jung J. Association of Kaposi's Sarcoma-Associated Herpesvirus ORF31 with ORF34 and ORF24 Is Critical for Late Gene Expression. J Virol. 2015 Jun 1; 89(11):6148-54. PMID: 25810551.
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      31. Chen Z, Shojaee S, Buchner M, Geng H, Lee JW, Klemm L, Titz B, Graeber TG, Park E, Tan YX, Satterthwaite A, Paietta E, Hunger SP, Willman CL, Melnick A, Loh ML, Jung J, Coligan JE, Bolland S, Mak TW, Limnander A, Jumaa H, Reth M, Weiss A, Lowell CA, Müschen M. Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia. Nature. 2015 May 21; 521(7552):357-61. PMID: 25799995.
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      32. Lee HR, Amatya R, Jung J. Multi-step regulation of innate immune signaling by Kaposi's sarcoma-associated herpesvirus. Virus Res. 2015 Nov 2; 209:39-44. PMID: 25796211.
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      33. He S, Zhao J, Song S, He X, Minassian A, Zhou Y, Zhang J, Brulois K, Wang Y, Cabo J, Zandi E, Liang C, Jung J, Zhang X, Feng P. Viral Pseudo-Enzymes Activate RIG-I via Deamidation to Evade Cytokine Production. Mol Cell. 2015 Apr 2; 58(1):134-46. PMID: 25752576.
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      34. Liang Q, Chang B, Lee P, Brulois KF, Ge J, Shi M, Rodgers MA, Feng P, Oh BH, Liang C, Jung J. Identification of the Essential Role of Viral Bcl-2 for Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication. J Virol. 2015 May 15; 89(10):5308-17. PMID: 25740994.
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      35. Gelgor A, Kalt I, Bergson S, Brulois KF, Jung J, Sarid R. Viral Bcl-2 Encoded by the Kaposi's Sarcoma-Associated Herpesvirus Is Vital for Virus Reactivation. J Virol. 2015 May 15; 89(10):5298-307. PMID: 25740992.
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      36. Liang C, Oh BH, Jung J. Novel functions of viral anti-apoptotic factors. Nat Rev Microbiol. 2015 Jan; 13(1):7-12. PMID: 25363821.
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      37. Lee MS, Jones T, Song DY, Jang JH, Jung J, Gao SJ. Exploitation of the Complement System by Oncogenic Kaposi's Sarcoma-Associated Herpesvirus for Cell Survival and Persistent Infection. PLoS Pathog. 2014 Sep; 10(9):e1004412. PMID: 25254972.
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      38. Shi M, Cho H, Inn KS, Yang A, Zhao Z, Liang Q, Versteeg GA, Amini-Bavil-Olyaee S, Wong LY, Zlokovic BV, Park HS, García-Sastre A, Jung J. Negative regulation of NF-?B activity by brain-specific TRIpartite Motif protein 9. Nat Commun. 2014; 5:4820. PMID: 25190485.
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      39. Bergson S, Kalt I, Itzhak I, Brulois KF, Jung J, Sarid R. Fluorescent Tagging and Cellular Distribution of the Kaposi's Sarcoma-Associated Herpesvirus ORF45 Tegument Protein. J Virol. 2014 Nov 1; 88(21):12839-52. PMID: 25165104.
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      40. Gong D, Wu NC, Xie Y, Feng J, Tong L, Brulois KF, Luan H, Du Y, Jung J, Wang CY, Kang MK, Park NH, Sun R, Wu TT. Kaposi's Sarcoma-Associated Herpesvirus ORF18 and ORF30 Are Essential for Late Gene Expression during Lytic Replication. J Virol. 2014 Oct 1; 88(19):11369-82. PMID: 25056896.
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      41. Rodgers MA, Bowman JW, Fujita H, Orazio N, Shi M, Liang Q, Amatya R, Kelly TJ, Iwai K, Ting J, Jung J. The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation. J Exp Med. 2014 Jun 30; 211(7):1333-47. PMID: 24958845.
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      42. Brulois K, Jung J. Interplay between Kaposi's sarcoma-associated herpesvirus and the innate immune system. Cytokine Growth Factor Rev. 2014 Oct; 25(5):597-609. PMID: 25037686.
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      43. Brulois K, Toth Z, Wong LY, Feng P, Gao SJ, Ensser A, Jung J. Kaposi's Sarcoma-Associated Herpesvirus K3 and K5 Ubiquitin E3 Ligases Have Stage-Specific Immune Evasion Roles during Lytic Replication. J Virol. 2014 Aug 15; 88(16):9335-49. PMID: 24899205.
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      44. Liang Q, Seo GJ, Choi YJ, Ge J, Rodgers MA, Shi M, Jung J. Autophagy side of MB21D1/cGAS DNA sensor. Autophagy. 2014 Jun; 10(6):1146-7. PMID: 24879161.
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      45. Zhu Y, Huang Y, Jung J, Lu C, Gao SJ. Viral miRNA targeting of bicistronic and polycistronic transcripts. Curr Opin Virol. 2014 Aug; 7:66-72. PMID: 24821460.
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      46. Buskiewicz IA, Koenig A, Roberts B, Russell J, Shi C, Lee SH, Jung J, Huber SA, Budd RC. c-FLIP-Short Reduces Type I Interferon Production and Increases Viremia with Coxsackievirus B3. PLoS One. 2014; 9(5):e96156. PMID: 24816846.
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      47. Kronstad LM, Brulois KF, Jung J, Glaunsinger BA. Reinitiation after Translation of Two Upstream Open Reading Frames (ORF) Governs Expression of the ORF35-37 Kaposi's Sarcoma-Associated Herpesvirus Polycistronic mRNA. J Virol. 2014 Jun; 88(11):6512-8. PMID: 24623444.
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      48. Liang Q, Seo GJ, Choi YJ, Kwak MJ, Ge J, Rodgers MA, Shi M, Leslie BJ, Hopfner KP, Ha T, Oh BH, Jung J. Crosstalk between the cGAS DNA Sensor and Beclin-1 Autophagy Protein Shapes Innate Antimicrobial Immune Responses. Cell Host Microbe. 2014 Feb 12; 15(2):228-38. PMID: 24528868.
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      49. Fan Y, Mao R, Yu Y, Liu S, Shi Z, Cheng J, Zhang H, An L, Zhao Y, Xu X, Chen Z, Kogiso M, Zhang D, Zhang H, Zhang P, Jung J, Li X, Xu G, Yang J. USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase. J Exp Med. 2014 Feb 10; 211(2):313-28. PMID: 24493797.
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      50. Full F, Jungnickl D, Reuter N, Bogner E, Brulois K, Scholz B, Stürzl M, Myoung J, Jung J, Stamminger T, Ensser A. Kaposi's Sarcoma Associated Herpesvirus Tegument Protein ORF75 Is Essential for Viral Lytic Replication and Plays a Critical Role in the Antagonization of ND10-Instituted Intrinsic Immunity. PLoS Pathog. 2014 Jan; 10(1):e1003863. PMID: 24453968.
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      51. Toth Z, Brulois K, Lee HR, Izumiya Y, Tepper C, Kung HJ, Jung J. Biphasic Euchromatin-to-Heterochromatin Transition on the KSHV Genome Following De Novo Infection. PLoS Pathog. 2013 Dec; 9(12):e1003813. PMID: 24367262.
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      52. Lee HR, Doganay S, Chung B, Toth Z, Brulois K, Lee S, Kanketayeva Z, Feng P, Ha T, Jung J. Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 4 (vIRF4) Targets Expression of Cellular IRF4 and the Myc Gene To Facilitate Lytic Replication. J Virol. 2014 Feb; 88(4):2183-94. PMID: 24335298.
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      53. Bai Z, Huang Y, Li W, Zhu Y, Jung J, Lu C, Gao SJ. Genomewide Mapping and Screening of Kaposi's Sarcoma-Associated Herpesvirus (KSHV) 3' Untranslated Regions Identify Bicistronic and Polycistronic Viral Transcripts as Frequent Targets of KSHV MicroRNAs. J Virol. 2014 Jan; 88(1):377-92. PMID: 24155407.
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      54. He Z, Zhao J, Zhang J, Jung J, Feng P. NF-?B Activation Coordinated by IKKß and IKK{varepsilon} Enables Latent Infection of Kaposi's Sarcoma-Associated Herpesvirus. J Virol. 2014 Jan; 88(1):444-55. PMID: 24155403.
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      55. Liang Q, Chang B, Brulois KF, Castro K, Min CK, Rodgers MA, Shi M, Ge J, Feng P, Oh BH, Jung J. Kaposi's sarcoma-associated herpesvirus K7 modulates Rubicon-mediated inhibition of autophagosome maturation. J Virol. 2013 Nov; 87(22):12499-503. PMID: 24027317.
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      56. Wong LY, Brulois K, Toth Z, Inn KS, Lee SH, O'Brien K, Lee H, Gao SJ, Cesarman E, Ensser A, Jung J. The product of Kaposi's sarcoma-associated herpesvirus immediate early gene K4.2 regulates immunoglobulin secretion and calcium homeostasis by interacting with and inhibiting pERP1. J Virol. 2013 Nov; 87(22):12069-79. PMID: 23986581.
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      57. Rodgers MA, Bowman JW, Liang Q, Jung J. Regulation where autophagy intersects the inflammasome. Antioxid Redox Signal. 2014 Jan 20; 20(3):495-506. PMID: 23642014.
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      58. Kim YK, Kwak MJ, Ku B, Suh HY, Joo K, Lee J, Jung J, Oh BH. Structural basis of intersubunit recognition in elongin BC-cullin 5-SOCS box ubiquitin-protein ligase complexes. Acta Crystallogr D Biol Crystallogr. 2013 Aug; 69(Pt 8):1587-97. PMID: 23897481.
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