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Hugo Rosen, MD

Title(s)Professor and Chair, Department of Medicine
Address1450 San Pablo St.
Off Campus
Los Angeles CA 90033
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    Other Positions
    Title(s)Kenneth T. Norris, Jr., Chair in Medicine


    Collapse Overview 
    Collapse Overview
    Hugo R. Rosen, MD is the Norris Chair of Medicine and Professor of Medicine, Immunology, and Molecular Microbiology.

    Rosen is a prolific physician-scientist with more than 180 original peer-reviewed manuscripts investigating the cellular and molecular underpinnings of a wide spectrum of innate and adaptive immune responses and developing novel paradigms in liver diseases. He has been the principal investigator of multiple National Institutes of Health grants (including two active RO1 grants), Center Grants, three T32 training grants and five VA Merit grants. He is an elected member of the American Society of Clinical Investigation (elected in 2008) and the American Association of Physicians. He has also received research funding from the American Society of Transplantation and American Association for the Study of Liver Diseases, having been named “Fellow” in the inaugural class of both societies. He currently serves as deputy editor of the journal Hepatology. He completed his internship and residency in internal medicine at Beth Israel Deaconess Medical Center, Harvard Medical School, followed by a fellowship in gastroenterology and transplant hepatology at UCLA. He will manage patients with acute and chronic liver disease at the Medical Center of USC and LAC+USC Medical Center.

    Collapse Research 
    Collapse Research Activities and Funding
    Innate Immunity, Cholesterol, and NASH Pathogenesis
    NIH/NIDDK R01DK117004Jan 20, 2020 - Dec 31, 2023
    Role: Principal Investigator
    Restoration of immunity and function with DAA treatment in HCV infection
    NIH/NIAID R01AI120622Feb 14, 2017 - Jan 31, 2021
    Role: Principal Investigator
    Mechanisms of hepatic innate immune activation by HCV
    NIH/NIAID R01AI127463Dec 15, 2016 - Nov 30, 2021
    Role: Co-Principal Investigator
    INNATE AND ADAPTIVE IMMUNITY TO HCV IN HUMAN PREGNANCY
    NIH/NICHD R01HD075549Feb 7, 2014 - Jan 31, 2019
    Role: Principal Investigator
    Novel Aspects of Hepatic Innate and Adaptive Immunity to HCV Infection
    VA I01BX002201Jan 1, 2014 - Dec 31, 2017
    Role: Principal Investigator
    Hepatitis C viral sensing by non-parenchymal liver cells (NPC)
    NIH/NIAID R21AI103361May 15, 2013 - Apr 30, 2015
    Role: Principal Investigator
    HEPATITIS C VIRAL INFECTION IN HUMAN PREGNANCY
    NIH/NIAID R56AI100991Sep 20, 2012 - Feb 28, 2014
    Role: Principal Investigator
    Functional attributes of CD8+ T cells in recovery of hepatitis C virus infection
    VA I01CX000111Oct 1, 2009 - Sep 30, 2013
    Role: Principal Investigator
    Midcareer Investigator Award in Patient-Oriented Research (K24)
    NIH/NIAID K24AI083742Sep 18, 2009 - Jul 31, 2014
    Role: Principal Investigator
    Innate Immune Responses During Therapy for Chronic HCV
    NIH/NIDDK R01DK071560Dec 1, 2005 - Jul 31, 2010
    Role: Principal Investigator
    Colorado Hepatitis C Cooperative Research Center
    NIH/NIAID U19AI066328Jul 1, 2005 - Aug 31, 2015
    Role: Principal Investigator
    Immune Responses in Acute Hepatitis C Infection
    NIH/NIDDK R01DK060590Sep 15, 2002 - May 31, 2009
    Role: Principal Investigator
    Cellular Immune Mechanisms of Resistance to HCV Therapy
    NIH/NIDDK U01DK060342Sep 30, 2001 - Jun 30, 2006
    Role: Principal Investigator
    USC Research Center for Liver Disease
    NIH/NIDDK P30DK048522Mar 1, 1997 - May 31, 2010
    Role: Principal Investigator
    Gastrointestinal Diseases Training Grant
    NIH/NIDDK T32DK007038Jul 1, 1975 - Nov 30, 2010
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Control of HCV Infection by Natural Killer Cells and Macrophages. Cold Spring Harb Perspect Med. 2020 Sep 01; 10(9). Rosen HR, Golden-Mason L. PMID: 31871225.
      View in: PubMed   Mentions:    Fields:    
    2. Increased hepatic and circulating chemokine and osteopontin expression occurs early in human NAFLD development. PLoS One. 2020; 15(7):e0236353. Kriss M, Golden-Mason L, Kaplan J, Mirshahi F, Setiawan VW, Sanyal AJ, Rosen HR. PMID: 32730345.
      View in: PubMed   Mentions:    Fields:    
    3. Considerations for prognosis, goals of care, and specialty palliative care for hospitalized patients with acute-on-chronic liver failure. Hepatology. 2020 May 16. Hernaez R, Patel A, Jackson LK, Braun UK, Walling AM, Rosen HR. PMID: 32416642.
      View in: PubMed   Mentions:    Fields:    
    4. Diet Associations With Nonalcoholic Fatty Liver Disease in an Ethnically Diverse Population: The Multiethnic Cohort. Hepatology. 2020 Jun; 71(6):1940-1952. Noureddin M, Zelber-Sagi S, Wilkens LR, Porcel J, Boushey CJ, Le Marchand L, Rosen HR, Setiawan VW. PMID: 31553803.
      View in: PubMed   Mentions: 1     Fields:    
    5. Chronic Liver Disease in Humans Causes Expansion and Differentiation of Liver Lymphatic Endothelial Cells. Front Immunol. 2019; 10:1036. Tamburini BAJ, Finlon JM, Gillen AE, Kriss MS, Riemondy KA, Fu R, Schuyler RP, Hesselberth JR, Rosen HR, Burchill MA. PMID: 31156626.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    6. Functional Microbiomics in Liver Transplantation: Identifying Novel Targets for Improving Allograft Outcomes. Transplantation. 2019 04; 103(4):668-678. Kriss M, Verna EC, Rosen HR, Lozupone CA. PMID: 30507741.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    7. Dietary Lipids Differentially Shape Nonalcoholic Steatohepatitis Progression and the Transcriptome of Kupffer Cells and Infiltrating Macrophages. Hepatology. 2019 07; 70(1):67-83. McGettigan B, McMahan R, Orlicky D, Burchill M, Danhorn T, Francis P, Cheng LL, Golden-Mason L, Jakubzick CV, Rosen HR. PMID: 30516830.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    8. Multi-Ancestry Genome-Wide Association Study of Spontaneous Clearance of Hepatitis C Virus. Gastroenterology. 2019 Apr; 156(5):1496-1507.e7. Vergara C, Thio CL, Johnson E, Kral AH, O'Brien TR, Goedert JJ, Mangia A, Piazzolla V, Mehta SH, Kirk GD, Kim AY, Lauer GM, Chung RT, Cox AL, Peters MG, Khakoo SI, Alric L, Cramp ME, Donfield SM, Edlin BR, Busch MP, Alexander G, Rosen HR, Murphy EL, Latanich R, Wojcik GL, Taub MA, Valencia A, Thomas DL, Duggal P. PMID: 30593799.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    9. Revisiting the Paradox of Interferon-Stimulated Gene Expression as a Predictor of Hepatitis C Virus Treatment Response, a Decade Later. Hepatology. 2018 12; 68(6):2053-2055. Golden-Mason L, Rosen HR. PMID: 30055107.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    10. Early and late changes in natural killer cells in response to ledipasvir/sofosbuvir treatment. Hepatol Commun. 2018 04; 2(4):364-375. Golden-Mason L, McMahan RH, Kriss MS, Kilgore AL, Cheng L, Dran RJ, Wieland A, Rosen HR. PMID: 29619416.
      View in: PubMed   Mentions:
    11. Fine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection. Sci Rep. 2017 Nov 20; 7(1):15843. Huang H, Duggal P, Thio CL, Latanich R, Goedert JJ, Mangia A, Cox AL, Kirk GD, Mehta S, Aneja J, Alric L, Donfield SM, Cramp ME, Khakoo SI, Tobler LH, Busch M, Alexander GJ, Rosen HR, Edlin BR, Segal FP, Lauer GM, Thomas DL, Daly MJ, Chung RT, Kim AY. PMID: 29158528.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    12. Hepatocyte-derived exosomes promote T follicular regulatory cell expansion during hepatitis C virus infection. Hepatology. 2018 01; 67(1):71-85. Cobb DA, Kim OK, Golden-Mason L, Rosen HR, Hahn YS. PMID: 28749570.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    13. Rapid reversal of innate immune dysregulation in blood of patients and livers of humanized mice with HCV following DAA therapy. PLoS One. 2017; 12(10):e0186213. Burchill MA, Roby JA, Crochet N, Wind-Rotolo M, Stone AE, Edwards MG, Dran RJ, Kriss MS, Gale M, Rosen HR. PMID: 29040318.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    14. NAM 2017 report: A national plan to eliminate hepatitis B and C in the United States by 2030 and the AASLD's response. Hepatology. 2017 10; 66(4):1020-1022. Rosen HR, Ghany MG, Chung RT, Lok ASF. PMID: 28714210.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    15. Galectin-9: Diverse roles in hepatic immune homeostasis and inflammation. Hepatology. 2017 07; 66(1):271-279. Golden-Mason L, Rosen HR. PMID: 28195343.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    16. Neutrophil-to-lymphocyte ratio correlates with proinflammatory neutrophils and predicts death in low model for end-stage liver disease patients with cirrhosis. Liver Transpl. 2017 02; 23(2):155-165. Kalra A, Wedd JP, Bambha KM, Gralla J, Golden-Mason L, Collins C, Rosen HR, Biggins SW. PMID: 28006875.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    17. Correction: Hepatitis C Virus Sensing by Human Trophoblasts Induces Innate Immune Responses and Recruitment of Maternal NK Cells: Potential Implications for Limiting Vertical Transmission. J Immunol. 2017 01 15; 198(2):972. Giugliano S, Petroff MG, Warren BD, Jasti S, Linscheid C, Ward A, Kramer A, Dobrinskikh E, Sheiko MA, Gale M, Golden-Mason L, Winn VD, Rosen HR. PMID: 28069758.
      View in: PubMed   Mentions:    Fields:    
    18. "Hep C, where art thou": What are the remaining (fundable) questions in hepatitis C virus research? Hepatology. 2017 01; 65(1):341-349. Rosen HR. PMID: 27640881.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    19. Free Fatty Acids Differentially Downregulate Chemokines in Liver Sinusoidal Endothelial Cells: Insights into Non-Alcoholic Fatty Liver Disease. PLoS One. 2016; 11(7):e0159217. McMahan RH, Porsche CE, Edwards MG, Rosen HR. PMID: 27454769.
      View in: PubMed   Mentions: 7     Fields:    
    20. Virtual memory T cells develop and mediate bystander protective immunity in an IL-15-dependent manner. Nat Commun. 2016 Apr 21; 7:11291. White JT, Cross EW, Burchill MA, Danhorn T, McCarter MD, Rosen HR, O'Connor B, Kedl RM. PMID: 27097762.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    21. Hepatitis C virus-cross-reactive TCR gene-modified T cells: a model for immunotherapy against diseases with genomic instability. J Leukoc Biol. 2016 09; 100(3):545-57. Spear TT, Riley TP, Lyons GE, Callender GG, Roszkowski JJ, Wang Y, Simms PE, Scurti GM, Foley KC, Murray DC, Hellman LM, McMahan RH, Iwashima M, Garrett-Mayer E, Rosen HR, Baker BM, Nishimura MI. PMID: 26921345.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    22. Hepatitis C Virus-Induced Myeloid-Derived Suppressor Cells Suppress NK Cell IFN-? Production by Altering Cellular Metabolism via Arginase-1. J Immunol. 2016 Mar 01; 196(5):2283-92. Goh CC, Roggerson KM, Lee HC, Golden-Mason L, Rosen HR, Hahn YS. PMID: 26826241.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    23. CD4+ and CD8+ T Cell Activation in Children with Hepatitis C. J Pediatr. 2016 Mar; 170:142-8.e1. Sheiko MA, Golden-Mason L, Giugliano S, Hurtado CW, Mack CL, Narkewicz MR, Rosen HR. PMID: 26743497.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    24. Variants in the LGALS9 Gene Are Associated With Development of Liver Disease in Heavy Consumers of Alcohol. Clin Gastroenterol Hepatol. 2016 May; 14(5):762-8.e1. Rosen HR, Golden-Mason L, Daly AK, Yang I, Day CP. PMID: 26598225.
      View in: PubMed   Mentions: 1     Fields:    
    25. Association Between Plasma Level of Galectin-9 and Survival of Patients With Drug-Induced Acute Liver Failure. Clin Gastroenterol Hepatol. 2016 Apr; 14(4):606-612.e3. Rosen HR, Biggins SW, Niki T, Gralla J, Hillman H, Hirashima M, Schilsky M, Lee WM. PMID: 26499927.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    26. HCV-infected cells and differentiation increase monocyte immunoregulatory galectin-9 production. J Leukoc Biol. 2016 Mar; 99(3):495-503. Harwood NM, Golden-Mason L, Cheng L, Rosen HR, Mengshol JA. PMID: 26475932.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    27. Hepatitis C Virus Sensing by Human Trophoblasts Induces Innate Immune Responses and Recruitment of Maternal NK Cells: Potential Implications for Limiting Vertical Transmission. J Immunol. 2015 10 15; 195(8):3737-47. Giugliano S, Petroff MG, Warren BD, Jasti S, Linscheid C, Ward A, Kramer A, Dobrinskikh E, Sheiko MA, Gale M, Golden-Mason L, Winn VD, Rosen HR. PMID: 26342030.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCellsCTClinical Trials
    28. Hepatitis C viral infection is associated with activated cytolytic natural killer cells expressing high levels of T cell immunoglobulin- and mucin-domain-containing molecule-3. Clin Immunol. 2015 May; 158(1):114-25. Golden-Mason L, Waasdorp Hurtado CE, Cheng L, Rosen HR. PMID: 25797693.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    29. Transmitted/founder hepatitis C viruses induce cell-type- and genotype-specific differences in innate signaling within the liver. mBio. 2015 Feb 24; 6(2):e02510. Mitchell AM, Stone AE, Cheng L, Ballinger K, Edwards MG, Stoddard M, Li H, Golden-Mason L, Shaw GM, Khetani S, Rosen HR. PMID: 25714713.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    30. Hepatitis C virus infection induces autocrine interferon signaling by human liver endothelial cells and release of exosomes, which inhibits viral replication. Gastroenterology. 2015 Feb; 148(2):392-402.e13. Giugliano S, Kriss M, Golden-Mason L, Dobrinskikh E, Stone AE, Soto-Gutierrez A, Mitchell A, Khetani SR, Yamane D, Stoddard M, Li H, Shaw GM, Edwards MG, Lemon SM, Gale M, Shah VH, Rosen HR. PMID: 25447848.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    31. Extracellular HCV-core protein induces an immature regulatory phenotype in NK cells: implications for outcome of acute infection. PLoS One. 2014; 9(7):e103219. Golden-Mason L, Hahn YS, Strong M, Cheng L, Rosen HR. PMID: 25076408.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    32. Hepatitis C virus core protein inhibits interferon production by a human plasmacytoid dendritic cell line and dysregulates interferon regulatory factor-7 and signal transducer and activator of transcription (STAT) 1 protein expression. PLoS One. 2014; 9(5):e95627. Stone AE, Mitchell A, Brownell J, Miklin DJ, Golden-Mason L, Polyak SJ, Gale MJ, Rosen HR. PMID: 24788809.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    33. High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase. Hepatology. 2013 Nov; 58(5):1632-43. Ishimoto T, Lanaspa MA, Rivard CJ, Roncal-Jimenez CA, Orlicky DJ, Cicerchi C, McMahan RH, Abdelmalek MF, Rosen HR, Jackman MR, MacLean PS, Diggle CP, Asipu A, Inaba S, Kosugi T, Sato W, Maruyama S, Sánchez-Lozada LG, Sautin YY, Hill JO, Bonthron DT, Johnson RJ. PMID: 23813872.
      View in: PubMed   Mentions: 75     Fields:    Translation:Animals
    34. Emerging concepts in immunity to hepatitis C virus infection. J Clin Invest. 2013 Oct; 123(10):4121-30. Rosen HR. PMID: 24084744.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    35. Natural killer cells: multifaceted players with key roles in hepatitis C immunity. Immunol Rev. 2013 Sep; 255(1):68-81. Golden-Mason L, Rosen HR. PMID: 23947348.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    36. Hepatitis C virus pathogen associated molecular pattern (PAMP) triggers production of lambda-interferons by human plasmacytoid dendritic cells. PLoS Pathog. 2013; 9(4):e1003316. Stone AE, Giugliano S, Schnell G, Cheng L, Leahy KF, Golden-Mason L, Gale M, Rosen HR. PMID: 23637605.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    37. Hepatitis C virus promotes T-helper (Th)17 responses through thymic stromal lymphopoietin production by infected hepatocytes. Hepatology. 2013 Apr; 57(4):1314-24. Lee HC, Sung SS, Krueger PD, Jo YA, Rosen HR, Ziegler SF, Hahn YS. PMID: 23150092.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    38. Bile acid receptor activation modulates hepatic monocyte activity and improves nonalcoholic fatty liver disease. J Biol Chem. 2013 Apr 26; 288(17):11761-70. McMahan RH, Wang XX, Cheng LL, Krisko T, Smith M, El Kasmi K, Pruzanski M, Adorini L, Golden-Mason L, Levi M, Rosen HR. PMID: 23460643.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    39. Genome-wide association study of spontaneous resolution of hepatitis C virus infection: data from multiple cohorts. Ann Intern Med. 2013 Feb 19; 158(4):235-45. Duggal P, Thio CL, Wojcik GL, Goedert JJ, Mangia A, Latanich R, Kim AY, Lauer GM, Chung RT, Peters MG, Kirk GD, Mehta SH, Cox AL, Khakoo SI, Alric L, Cramp ME, Donfield SM, Edlin BR, Tobler LH, Busch MP, Alexander G, Rosen HR, Gao X, Abdel-Hamid M, Apps R, Carrington M, Thomas DL. PMID: 23420232.
      View in: PubMed   Mentions: 72     Fields:    Translation:Humans
    40. Galectin-9 functionally impairs natural killer cells in humans and mice. J Virol. 2013 May; 87(9):4835-45. Golden-Mason L, McMahan RH, Strong M, Reisdorph R, Mahaffey S, Palmer BE, Cheng L, Kulesza C, Hirashima M, Niki T, Rosen HR. PMID: 23408620.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    41. Differential effects of donor and recipient IL28B and DDX58 SNPs on severity of HCV after liver transplantation. J Hepatol. 2013 May; 58(5):969-76. Biggins SW, Trotter J, Gralla J, Burton JR, Bambha KM, Dodge J, Brocato M, Cheng L, McQueen M, Forman L, Chang M, Kam I, Everson G, Spritz RA, Klintmalm G, Rosen HR. PMID: 23333445.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    42. Race- and gender-related variation in natural killer p46 expression associated with differential anti-hepatitis C virus immunity. Hepatology. 2012 Oct; 56(4):1214-22. Golden-Mason L, Stone AE, Bambha KM, Cheng L, Rosen HR. PMID: 22505144.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    43. Myeloid suppressor cells induced by hepatitis C virus suppress T-cell responses through the production of reactive oxygen species. Hepatology. 2012 Feb; 55(2):343-53. Tacke RS, Lee HC, Goh C, Courtney J, Polyak SJ, Rosen HR, Hahn YS. PMID: 21953144.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    44. Of mice and men, calcineurin inhibitors and hepatitis C. Liver Transpl. 2012 Jan; 18(1):1-4. Rutebemberwa A, Rosen HR. PMID: 22034173.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    45. Interleukin (IL)-17/IL-22-producing T cells enriched within the liver of patients with chronic hepatitis C viral (HCV) infection. Dig Dis Sci. 2012 Feb; 57(2):381-9. Foster RG, Golden-Mason L, Rutebemberwa A, Rosen HR. PMID: 22183819.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    46. Identification of osteopontin as a novel marker for early hepatocellular carcinoma. Hepatology. 2012 Feb; 55(2):483-90. Shang S, Plymoth A, Ge S, Feng Z, Rosen HR, Sangrajrang S, Hainaut P, Marrero JA, Beretta L. PMID: 21953299.
      View in: PubMed   Mentions: 94     Fields:    Translation:Humans
    47. Natural killer inhibitory receptor expression associated with treatment failure and interleukin-28B genotype in patients with chronic hepatitis C. Hepatology. 2011 Nov; 54(5):1559-69. Golden-Mason L, Bambha KM, Cheng L, Howell CD, Taylor MW, Clark PJ, Afdhal N, Rosen HR. PMID: 21983945.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    48. Clinical practice. Chronic hepatitis C infection. N Engl J Med. 2011 Jun 23; 364(25):2429-38. Rosen HR. PMID: 21696309.
      View in: PubMed   Mentions: 130     Fields:    Translation:HumansCells
    49. Genetic diversity of near genome-wide hepatitis C virus sequences during chronic infection: evidence for protein structural conservation over time. PLoS One. 2011 May 05; 6(5):e19562. Li H, Hughes AL, Bano N, McArdle S, Livingston S, Deubner H, McMahon BJ, Townshend-Bulson L, McMahan R, Rosen HR, Gretch DR. PMID: 21573177.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    50. Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity. J Clin Invest. 2010 Dec; 120(12):4546-57. McMahan RH, Golden-Mason L, Nishimura MI, McMahon BJ, Kemper M, Allen TM, Gretch DR, Rosen HR. PMID: 21084749.
      View in: PubMed   Mentions: 138     Fields:    Translation:HumansCells
    51. Increased natural killer cell cytotoxicity and NKp30 expression protects against hepatitis C virus infection in high-risk individuals and inhibits replication in vitro. Hepatology. 2010 Nov; 52(5):1581-9. Golden-Mason L, Cox AL, Randall JA, Cheng L, Rosen HR. PMID: 20812318.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    52. Innate immune function in placenta and cord blood of hepatitis C--seropositive mother-infant dyads. PLoS One. 2010 Aug 30; 5(8):e12232. Hurtado CW, Golden-Mason L, Brocato M, Krull M, Narkewicz MR, Rosen HR. PMID: 20814429.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    53. Transduction of human T cells with a novel T-cell receptor confers anti-HCV reactivity. PLoS Pathog. 2010 Jul 29; 6(7):e1001018. Zhang Y, Liu Y, Moxley KM, Golden-Mason L, Hughes MG, Liu T, Heemskerk MH, Rosen HR, Nishimura MI. PMID: 20686664.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    54. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. J Infect Dis. 2010 May 01; 201(9):1371-80. Mosbruger TL, Duggal P, Goedert JJ, Kirk GD, Hoots WK, Tobler LH, Busch M, Peters MG, Rosen HR, Thomas DL, Thio CL. PMID: 20331378.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    55. Functional characterization of core genes from patients with acute hepatitis C virus infection. J Infect Dis. 2010 Mar 15; 201(6):912-22. Tang X, Wagoner J, Negash A, Austin M, McLauchlan J, Hahn YS, Rosen HR, Polyak SJ. PMID: 20170366.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    56. A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in hepatitis C infection. PLoS One. 2010 Mar 04; 5(3):e9504. Mengshol JA, Golden-Mason L, Arikawa T, Smith M, Niki T, McWilliams R, Randall JA, McMahan R, Zimmerman MA, Rangachari M, Dobrinskikh E, Busson P, Polyak SJ, Hirashima M, Rosen HR. PMID: 20209097.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansCells
    57. Comprehensive assessment of chemokine expression profiles by flow cytometry. J Clin Invest. 2010 Mar; 120(3):907-23. Eberlein J, Nguyen TT, Victorino F, Golden-Mason L, Rosen HR, Homann D. PMID: 20197626.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    58. Protective effect of human leukocyte antigen B27 in hepatitis C virus infection requires the presence of a genotype-specific immunodominant CD8+ T-cell epitope. Hepatology. 2010 Jan; 51(1):54-62. Neumann-Haefelin C, Timm J, Schmidt J, Kersting N, Fitzmaurice K, Oniangue-Ndza C, Kemper MN, Humphreys I, McKiernan S, Kelleher D, Lohmann V, Bowness P, Huzly D, Rosen HR, Kim AY, Lauer GM, Allen TM, Barnes E, Roggendorf M, Blum HE, Thimme R. PMID: 20034048.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    59. Human liver transplantation as a model to study hepatitis C virus pathogenesis. Liver Transpl. 2009 Nov; 15(11):1395-411. Hughes MG, Rosen HR. PMID: 19877210.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    60. Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature. 2009 Oct 08; 461(7265):798-801. Thomas DL, Thio CL, Martin MP, Qi Y, Ge D, O'Huigin C, Kidd J, Kidd K, Khakoo SI, Alexander G, Goedert JJ, Kirk GD, Donfield SM, Rosen HR, Tobler LH, Busch MP, McHutchison JG, Goldstein DB, Carrington M. PMID: 19759533.
      View in: PubMed   Mentions: 691     Fields:    Translation:HumansCells
    61. Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells. J Virol. 2009 Sep; 83(18):9122-30. Golden-Mason L, Palmer BE, Kassam N, Townshend-Bulson L, Livingston S, McMahon BJ, Castelblanco N, Kuchroo V, Gretch DR, Rosen HR. PMID: 19587053.
      View in: PubMed   Mentions: 200     Fields:    Translation:HumansCells
    62. Frequency of gC1qR+CD4+ T cells increases during acute hepatitis C virus infection and remains elevated in patients with chronic infection. Clin Immunol. 2009 Sep; 132(3):401-11. Cummings KL, Rosen HR, Hahn YS. PMID: 19473882.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    63. Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naïve patients. Hepatology. 2008 Dec; 48(6):1769-78. Kuntzen T, Timm J, Berical A, Lennon N, Berlin AM, Young SK, Lee B, Heckerman D, Carlson J, Reyor LL, Kleyman M, McMahon CM, Birch C, Schulze Zur Wiesch J, Ledlie T, Koehrsen M, Kodira C, Roberts AD, Lauer GM, Rosen HR, Bihl F, Cerny A, Spengler U, Liu Z, Kim AY, Xing Y, Schneidewind A, Madey MA, Fleckenstein JF, Park VM, Galagan JE, Nusbaum C, Walker BD, Lake-Bakaar GV, Daar ES, Jacobson IM, Gomperts ED, Edlin BR, Donfield SM, Chung RT, Talal AH, Marion T, Birren BW, Henn MR, Allen TM. PMID: 19026009.
      View in: PubMed   Mentions: 118     Fields:    Translation:HumansCells
    64. Genetic markers of IgG influence the outcome of infection with hepatitis C virus. J Infect Dis. 2008 Nov 01; 198(9):1334-6. Pandey JP, Namboodiri AM, Luo Y, Wu Y, Elston RC, Thomas DL, Rosen HR, Goedert JJ. PMID: 18855559.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    65. Polymorphism in the human major histocompatibility complex and early viral decline during treatment of chronic hepatitis C. Antimicrob Agents Chemother. 2009 Feb; 53(2):615-21. Yee LJ, Im K, Wahed AS, Bugawan T, Li J, Rhodes SL, Erlich H, Rosen HR, Liang TJ, Yang H. PMID: 18852273.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    66. Prospective analysis of effector and regulatory CD4+ T cells in chronic HCV patients undergoing combination antiviral therapy. J Hepatol. 2008 Sep; 49(3):329-38. Burton JR, Klarquist J, Im K, Smyk-Pearson S, Golden-Mason L, Castelblanco N, Terrault N, Rosen HR. PMID: 18644644.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCellsCTClinical Trials
    67. Association of single nucleotide polymorphisms in interferon signaling pathway genes and interferon-stimulated genes with the response to interferon therapy for chronic hepatitis C. J Hepatol. 2008 Aug; 49(2):184-91. Su X, Yee LJ, Im K, Rhodes SL, Tang Y, Tong X, Howell C, Ramcharran D, Rosen HR, Taylor MW, Liang TJ, Yang H. PMID: 18571276.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    68. Transplantation immunology: what the clinician needs to know for immunotherapy. Gastroenterology. 2008 May; 134(6):1789-801. Rosen HR. PMID: 18471555.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    69. Cutting edge: programmed death-1 expression is increased on immunocytes in chronic hepatitis C virus and predicts failure of response to antiviral therapy: race-dependent differences. J Immunol. 2008 Mar 15; 180(6):3637-41. Golden-Mason L, Klarquist J, Wahed AS, Rosen HR. PMID: 18322167.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    70. Pretransplantation CD56(+) innate lymphocyte populations associated with severity of hepatitis C virus recurrence. Liver Transpl. 2008 Jan; 14(1):31-40. Rosen HR, Doherty DG, Madrigal-Estebas L, O'Farrelly C, Golden-Mason L. PMID: 18161829.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    71. Functional suppression by FoxP3+CD4+CD25(high) regulatory T cells during acute hepatitis C virus infection. J Infect Dis. 2008 Jan 01; 197(1):46-57. Smyk-Pearson S, Golden-Mason L, Klarquist J, Burton JR, Tester IA, Wang CC, Culbertson N, Vandenbark AA, Rosen HR. PMID: 18171284.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    72. Spontaneous recovery in acute human hepatitis C virus infection: functional T-cell thresholds and relative importance of CD4 help. J Virol. 2008 Feb; 82(4):1827-37. Smyk-Pearson S, Tester IA, Klarquist J, Palmer BE, Pawlotsky JM, Golden-Mason L, Rosen HR. PMID: 18045940.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    73. Mechanisms of Disease: HCV-induced liver injury. Nat Clin Pract Gastroenterol Hepatol. 2007 Nov; 4(11):622-34. Mengshol JA, Golden-Mason L, Rosen HR. PMID: 17978819.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    74. Acute hepatitis C in a contemporary US cohort: modes of acquisition and factors influencing viral clearance. J Infect Dis. 2007 Nov 15; 196(10):1474-82. Wang CC, Krantz E, Klarquist J, Krows M, McBride L, Scott EP, Shaw-Stiffel T, Weston SJ, Thiede H, Wald A, Rosen HR. PMID: 18008226.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCells
    75. Selective decrease in hepatitis C virus-specific immunity among African Americans and outcome of antiviral therapy. Hepatology. 2007 Aug; 46(2):350-8. Rosen HR, Weston SJ, Im K, Yang H, Burton JR, Erlich H, Klarquist J, Belle SH. PMID: 17659573.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    76. Upregulation of PD-1 expression on circulating and intrahepatic hepatitis C virus-specific CD8+ T cells associated with reversible immune dysfunction. J Virol. 2007 Sep; 81(17):9249-58. Golden-Mason L, Palmer B, Klarquist J, Mengshol JA, Castelblanco N, Rosen HR. PMID: 17567698.
      View in: PubMed   Mentions: 169     Fields:    Translation:HumansCells
    77. Phenotypic and functional changes of cytotoxic CD56pos natural T cells determine outcome of acute hepatitis C virus infection. J Virol. 2007 Sep; 81(17):9292-8. Golden-Mason L, Castelblanco N, O'Farrelly C, Rosen HR. PMID: 17553896.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    78. Engulfment of apoptotic cells expressing HCV proteins leads to differential chemokine expression and STAT signaling in human dendritic cells. Hepatology. 2007 Jun; 45(6):1422-32. Wertheimer AM, Polyak SJ, Leistikow R, Rosen HR. PMID: 17538964.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    79. Assessment of FIBROSpect II to detect hepatic fibrosis in chronic hepatitis C patients. Am J Med. 2007 Mar; 120(3):280.e9-14. Zaman A, Rosen HR, Ingram K, Corless CL, Oh E, Smith K. PMID: 17349453.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    80. A functional SNP of interferon-gamma gene is important for interferon-alpha-induced and spontaneous recovery from hepatitis C virus infection. Proc Natl Acad Sci U S A. 2007 Jan 16; 104(3):985-90. Huang Y, Yang H, Borg BB, Su X, Rhodes SL, Yang K, Tong X, Tang G, Howell CD, Rosen HR, Thio CL, Thomas DL, Alter HJ, Sapp RK, Liang TJ. PMID: 17215375.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    81. Loss of IL-7 receptor alpha-chain (CD127) expression in acute HCV infection associated with viral persistence. Hepatology. 2006 Nov; 44(5):1098-109. Golden-Mason L, Burton JR, Castelblanco N, Klarquist J, Benlloch S, Wang C, Rosen HR. PMID: 17058243.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    82. Acute rejection in HCV-infected liver transplant recipients: The great conundrum. Liver Transpl. 2006 Nov; 12(11 Suppl 2):S38-47. Burton JR, Rosen HR. PMID: 17051562.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    83. Differential antigenic hierarchy associated with spontaneous recovery from hepatitis C virus infection: implications for vaccine design. J Infect Dis. 2006 Aug 15; 194(4):454-63. Smyk-Pearson S, Tester IA, Lezotte D, Sasaki AW, Lewinsohn DM, Rosen HR. PMID: 16845628.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    84. Diagnosis and management of allograft failure. Clin Liver Dis. 2006 May; 10(2):407-35, x. Burton JR, Rosen HR. PMID: 16971269.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    85. Identification of a hepatitis C virus-reactive T cell receptor that does not require CD8 for target cell recognition. Hepatology. 2006 May; 43(5):973-81. Callender GG, Rosen HR, Roszkowski JJ, Lyons GE, Li M, Moore T, Brasic N, McKee MD, Nishimura MI. PMID: 16628627.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    86. Natural killer cells: primary target for hepatitis C virus immune evasion strategies? Liver Transpl. 2006 Mar; 12(3):363-72. Golden-Mason L, Rosen HR. PMID: 16498647.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    87. Liver retransplantation for hepatitis C virus recurrence: a survey of liver transplant programs in the United States. Clin Gastroenterol Hepatol. 2005 Jul; 3(7):700-4. Burton JR, Rosen HR. PMID: 16206504.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    88. Immune evasion versus recovery after acute hepatitis C virus infection from a shared source. J Exp Med. 2005 Jun 06; 201(11):1725-31. Tester I, Smyk-Pearson S, Wang P, Wertheimer A, Yao E, Lewinsohn DM, Tavis JE, Rosen HR. PMID: 15939788.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCells
    89. Reconstitution of hepatitis C virus-specific T-cellmediated immunity after liver transplantation. Hepatology. 2005 Jan; 41(1):72-81. Weston SJ, Leistikow RL, Reddy KR, Torres M, Wertheimer AM, Lewinsohn DM, Chou S, Davey MP, Corless C, O'Farrelly C, Nelson DR, Rosen HR. PMID: 15619226.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    90. An immunomodulatory role for CD4(+)CD25(+) regulatory T lymphocytes in hepatitis C virus infection. Hepatology. 2004 Nov; 40(5):1062-71. Cabrera R, Tu Z, Xu Y, Firpi RJ, Rosen HR, Liu C, Nelson DR. PMID: 15486925.
      View in: PubMed   Mentions: 162     Fields:    Translation:HumansCells
    91. Direct enumeration and functional assessment of circulating dendritic cells in patients with liver disease. Hepatology. 2004 Aug; 40(2):335-45. Wertheimer AM, Bakke A, Rosen HR. PMID: 15368438.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansCells
    92. Comparative analysis of outcome following liver transplantation in US veterans. Am J Transplant. 2004 May; 4(5):788-95. Austin GL, Sasaki AW, Zaman A, Rabkin JM, Olyaei A, Ruimy R, Orloff SL, Ham J, Rosen HR. PMID: 15084176.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    93. Changing compliance to the American College of Gastroenterology guidelines for the management of variceal hemorrhage: a regional survey. Am J Gastroenterol. 2004 Apr; 99(4):645-9. Zaman A, Hapke RJ, Flora K, Rosen HR, Benner KG. PMID: 15089896.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    94. Treatment of hepatitis C in solid organ transplantation. Drugs. 2004; 64(5):489-98. Chan SE, Schwartz JM, Rosen HR. PMID: 14977386.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    95. DNA vaccination protects mice against challenge with Listeria monocytogenes expressing the hepatitis C virus NS3 protein. Infect Immun. 2003 Nov; 71(11):6372-80. Simon BE, Cornell KA, Clark TR, Chou S, Rosen HR, Barry RA. PMID: 14573658.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCellsPHPublic Health
    96. Hepatitis C pathogenesis: mechanisms of viral clearance and liver injury. Liver Transpl. 2003 Nov; 9(11):S35-43. Rosen HR. PMID: 14586893.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    97. Graft failure from severe recurrent primary sclerosing cholangitis following orthotopic liver transplantation. J Clin Gastroenterol. 2003 Oct; 37(4):344-7. Gopal DV, Corless CL, Rabkin JM, Olyaei AJ, Rosen HR. PMID: 14506394.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    98. Outcome and management of hepatitis C in liver transplant recipients. Clin Infect Dis. 2003 Sep 15; 37(6):807-12. Chan SE, Rosen HR. PMID: 12955642.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    99. Validation and refinement of survival models for liver retransplantation. Hepatology. 2003 Aug; 38(2):460-9. Rosen HR, Prieto M, Casanovas-Taltavull T, Cuervas-Mons V, Guckelberger O, Muiesan P, Strong RW, Bechstein WO, O'grady J, Zaman A, Chan B, Berenguer J, Williams R, Heaton N, Neuhaus P. PMID: 12883491.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    100. Duration of antiviral therapy for cholestatic HCV recurrence may need to be indefinite. Liver Transpl. 2003 Apr; 9(4):348-53. Gopal DV, Rosen HR. PMID: 12682884.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    101. Novel CD4+ and CD8+ T-cell determinants within the NS3 protein in subjects with spontaneously resolved HCV infection. Hepatology. 2003 Mar; 37(3):577-89. Wertheimer AM, Miner C, Lewinsohn DM, Sasaki AW, Kaufman E, Rosen HR. PMID: 12601356.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    102. A longitudinal analysis of T-cell epitope-coding regions of hepatitis C virus after liver transplantation. Transplantation. 2002 Jul 27; 74(2):209-16. Rosen HR, Marousek G, Chou S. PMID: 12151733.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    103. Early hepatitis C viral kinetics correlate with long-term outcome in patients receiving high dose induction followed by combination interferon and ribavirin therapy. J Hepatol. 2002 Jul; 37(1):124-30. Rosen HR, Ribeiro RR, Weinberger L, Wolf S, Chung M, Gretch DR, Perelson AS. PMID: 12076871.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCellsCTClinical Trials
    104. Hepatitis C quasispecies and severity of recurrence: cause, consequence, or coincidence? Liver Transpl. 2002 Jul; 8(7):646-8. Rosen HR, Schwartz JM. PMID: 12089722.
      View in: PubMed   Mentions: 2     Fields:    
    105. Analysis of sequence configurations of the ISDR, PKR-binding domain, and V3 region as predictors of response to induction interferon-alpha and ribavirin therapy in chronic hepatitis C infection. Dig Dis Sci. 2002 Jun; 47(6):1195-205. Murphy MD, Rosen HR, Marousek GI, Chou S. PMID: 12064791.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    106. Frequencies of HCV-specific effector CD4+ T cells by flow cytometry: correlation with clinical disease stages. Hepatology. 2002 Jan; 35(1):190-8. Rosen HR, Miner C, Sasaki AW, Lewinsohn DM, Conrad AJ, Bakke A, Bouwer HG, Hinrichs DJ. PMID: 11786976.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansCells
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