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Hugo Rosen, MD

TitleProfessor and Chair, Department of Medicine
InstitutionUniversity of Southern California
DepartmentMedicine
Address1450 San Pablo St.
Off Campus
Los Angeles CA 90033
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    Other Positions
    TitleKenneth T. Norris, Jr., Chair in Medicine


    Collapse Overview 
    Collapse Overview
    Hugo R. Rosen, MD is the Norris Chair of Medicine and Professor of Medicine, Immunology, and Molecular Microbiology.

    Rosen is a prolific physician-scientist with more than 180 original peer-reviewed manuscripts investigating the cellular and molecular underpinnings of a wide spectrum of innate and adaptive immune responses and developing novel paradigms in liver diseases. He has been the principal investigator of multiple National Institutes of Health grants (including two active RO1 grants), Center Grants, three T32 training grants and five VA Merit grants. He is an elected member of the American Society of Clinical Investigation (elected in 2008) and the American Association of Physicians. He has also received research funding from the American Society of Transplantation and American Association for the Study of Liver Diseases, having been named “Fellow” in the inaugural class of both societies. He currently serves as deputy editor of the journal Hepatology. He completed his internship and residency in internal medicine at Beth Israel Deaconess Medical Center, Harvard Medical School, followed by a fellowship in gastroenterology and transplant hepatology at UCLA. He will manage patients with acute and chronic liver disease at the Medical Center of USC and LAC+USC Medical Center.


    Collapse Research 
    Collapse Research Activities and Funding
    RESUBMISSION -R01 AI120622 ?Restoration of Immunity and Function with DAA Treatment in HCV infection
    NIH/NIAID R01AI120622Feb 14, 2017 - Jan 31, 2021
    Role: Principal Investigator
    Mechanisms of hepatic innate immune activation by HCV
    NIH/NIAID R01AI127463Dec 15, 2016 - Nov 30, 2021
    Role: Co-Principal Investigator
    INNATE AND ADAPTIVE IMMUNITY TO HCV IN HUMAN PREGNANCY
    NIH/NICHD R01HD075549Feb 7, 2014 - Jan 31, 2019
    Role: Principal Investigator
    Novel Aspects of Hepatic Innate and Adaptive Immunity to HCV Infection
    VA I01BX002201Jan 1, 2014 - Dec 31, 2017
    Role: Principal Investigator
    Hepatitis C viral sensing by non-parenchymal liver cells (NPC)
    NIH/NIAID R21AI103361May 15, 2013 - Apr 30, 2015
    Role: Principal Investigator
    HEPATITIS C VIRAL INFECTION IN HUMAN PREGNANCY
    NIH/NIAID R56AI100991Sep 20, 2012 - Feb 28, 2014
    Role: Principal Investigator
    Functional attributes of CD8+ T cells in recovery of hepatitis C virus infection
    VA I01CX000111Oct 1, 2009 - Sep 30, 2013
    Role: Principal Investigator
    Midcareer Investigator Award in Patient-Oriented Research (K24)
    NIH/NIAID K24AI083742Sep 18, 2009 - Jul 31, 2014
    Role: Principal Investigator
    Innate Immune Responses During Therapy for Chronic HCV
    NIH/NIDDK R01DK071560Sep 30, 2005 - Jul 31, 2010
    Role: Principal Investigator
    Colorado Hepatitis C Cooperative Research Center
    NIH/NIAID U19AI066328Jul 1, 2005 - Aug 31, 2015
    Role: Principal Investigator
    Immune Responses in Acute Hepatitis C Infection
    NIH/NIDDK R01DK060590Sep 15, 2002 - Aug 31, 2011
    Role: Principal Investigator
    Cellular Immune Mechanisms of Resistance to HCV Therapy
    NIH/NIDDK U01DK060342Sep 30, 2001 - Apr 30, 2007
    Role: Principal Investigator
    Gastrointestinal Diseases Training Grant
    NIH/NIDDK T32DK007038Jul 1, 1975 - Jun 30, 2021
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Golden-Mason L, Rosen H. Revisiting the Paradox of ISG expression as a predictor of HCV treatment response, a decade later. Hepatology. 2018 Jul 28. PMID: 30055107.
      View in: PubMed
    2. Golden-Mason L, McMahan RH, Kriss MS, Kilgore AL, Cheng L, Dran RJ, Wieland A, Rosen H. Early and late changes in natural killer cells in response to ledipasvir/sofosbuvir treatment. Hepatol Commun. 2018 04; 2(4):364-375. PMID: 29619416.
      View in: PubMed
    3. Huang H, Duggal P, Thio CL, Latanich R, Goedert JJ, Mangia A, Cox AL, Kirk GD, Mehta S, Aneja J, Alric L, Donfield SM, Cramp ME, Khakoo SI, Tobler LH, Busch M, Alexander GJ, Rosen H, Edlin BR, Segal FP, Lauer GM, Thomas DL, Daly MJ, Chung RT, Kim AY. Fine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection. Sci Rep. 2017 Nov 20; 7(1):15843. PMID: 29158528.
      View in: PubMed
    4. Cobb DA, Kim OK, Golden-Mason L, Rosen H, Hahn YS. Hepatocyte-derived exosomes promote T follicular regulatory cell expansion during hepatitis C virus infection. Hepatology. 2018 01; 67(1):71-85. PMID: 28749570.
      View in: PubMed
    5. Burchill MA, Roby JA, Crochet N, Wind-Rotolo M, Stone AE, Edwards MG, Dran RJ, Kriss MS, Gale M, Rosen H. Rapid reversal of innate immune dysregulation in blood of patients and livers of humanized mice with HCV following DAA therapy. PLoS One. 2017; 12(10):e0186213. PMID: 29040318.
      View in: PubMed
    6. Rosen H, Ghany MG, Chung RT, Lok ASF. NAM 2017 report: A national plan to eliminate hepatitis B and C in the United States by 2030 and the AASLD's response. Hepatology. 2017 10; 66(4):1020-1022. PMID: 28714210.
      View in: PubMed
    7. Golden-Mason L, Rosen H. Galectin-9: Diverse roles in hepatic immune homeostasis and inflammation. Hepatology. 2017 07; 66(1):271-279. PMID: 28195343.
      View in: PubMed
    8. Kalra A, Wedd JP, Bambha KM, Gralla J, Golden-Mason L, Collins C, Rosen H, Biggins SW. Neutrophil-to-lymphocyte ratio correlates with proinflammatory neutrophils and predicts death in low model for end-stage liver disease patients with cirrhosis. Liver Transpl. 2017 02; 23(2):155-165. PMID: 28006875.
      View in: PubMed
    9. Giugliano S, Petroff MG, Warren BD, Jasti S, Linscheid C, Ward A, Kramer A, Dobrinskikh E, Sheiko MA, Gale M, Golden-Mason L, Winn VD, Rosen H. Correction: Hepatitis C Virus Sensing by Human Trophoblasts Induces Innate Immune Responses and Recruitment of Maternal NK Cells: Potential Implications for Limiting Vertical Transmission. J Immunol. 2017 01 15; 198(2):972. PMID: 28069758.
      View in: PubMed
    10. Rosen H. "Hep C, where art thou": What are the remaining (fundable) questions in hepatitis C virus research? Hepatology. 2017 01; 65(1):341-349. PMID: 27640881.
      View in: PubMed
    11. McMahan RH, Porsche CE, Edwards MG, Rosen H. Free Fatty Acids Differentially Downregulate Chemokines in Liver Sinusoidal Endothelial Cells: Insights into Non-Alcoholic Fatty Liver Disease. PLoS One. 2016; 11(7):e0159217. PMID: 27454769; PMCID: PMC4959750.
    12. Laskey HL, Schomaker N, Hung KW, Asrani SK, Jennings L, Nydam TL, Gralla J, Wiseman A, Rosen H, Biggins SW. Predicting renal recovery after liver transplant with severe pretransplant subacute kidney injury: The impact of warm ischemia time. Liver Transpl. 2016 08; 22(8):1085-91. PMID: 27302834.
      View in: PubMed
    13. White JT, Cross EW, Burchill MA, Danhorn T, McCarter MD, Rosen H, O'Connor B, Kedl RM. Virtual memory T cells develop and mediate bystander protective immunity in an IL-15-dependent manner. Nat Commun. 2016 Apr 21; 7:11291. PMID: 27097762.
      View in: PubMed
    14. Goh CC, Roggerson KM, Lee HC, Golden-Mason L, Rosen H, Hahn YS. Hepatitis C Virus-Induced Myeloid-Derived Suppressor Cells Suppress NK Cell IFN-? Production by Altering Cellular Metabolism via Arginase-1. J Immunol. 2016 Mar 01; 196(5):2283-92. PMID: 26826241; PMCID: PMC4761460 [Available on 03/01/17].
    15. Sheiko MA, Golden-Mason L, Giugliano S, Hurtado CW, Mack CL, Narkewicz MR, Rosen H. CD4+ and CD8+ T Cell Activation in Children with Hepatitis C. J Pediatr. 2016 Mar; 170:142-8.e1. PMID: 26743497; PMCID: PMC4833455 [Available on 03/01/17].
    16. Rosen H, Golden-Mason L, Daly AK, Yang I, Day CP. Variants in the LGALS9 Gene Are Associated With Development of Liver Disease in Heavy Consumers of Alcohol. Clin Gastroenterol Hepatol. 2016 May; 14(5):762-8.e1. PMID: 26598225.
      View in: PubMed
    17. Hung K, Gralla J, Dodge JL, Bambha KM, Dirchwolf M, Rosen H, Biggins SW. Optimizing repeat liver transplant graft utility through strategic matching of donor and recipient characteristics. Liver Transpl. 2015 Nov; 21(11):1365-73. PMID: 25865434.
      View in: PubMed
    18. Rosen H, Biggins SW, Niki T, Gralla J, Hillman H, Hirashima M, Schilsky M, Lee WM. Association Between Plasma Level of Galectin-9 and Survival of Patients With Drug-Induced Acute Liver Failure. Clin Gastroenterol Hepatol. 2016 Apr; 14(4):606-612.e3. PMID: 26499927.
      View in: PubMed
    19. Harwood NM, Golden-Mason L, Cheng L, Rosen H, Mengshol JA. HCV-infected cells and differentiation increase monocyte immunoregulatory galectin-9 production. J Leukoc Biol. 2016 Mar; 99(3):495-503. PMID: 26475932.
      View in: PubMed
    20. Giugliano S, Petroff MG, Warren BD, Jasti S, Linscheid C, Ward A, Kramer A, Dobrinskikh E, Sheiko MA, Gale M, Golden-Mason L, Winn VD, Rosen H. Hepatitis C Virus Sensing by Human Trophoblasts Induces Innate Immune Responses and Recruitment of Maternal NK Cells: Potential Implications for Limiting Vertical Transmission. J Immunol. 2015 10 15; 195(8):3737-47. PMID: 26342030; PMCID: PMC4592818 [Available on 10/15/16].
    21. Golden-Mason L, Waasdorp Hurtado CE, Cheng L, Rosen H. Hepatitis C viral infection is associated with activated cytolytic natural killer cells expressing high levels of T cell immunoglobulin- and mucin-domain-containing molecule-3. Clin Immunol. 2015 May; 158(1):114-25. PMID: 25797693.
      View in: PubMed
    22. Mitchell AM, Stone AE, Cheng L, Ballinger K, Edwards MG, Stoddard M, Li H, Golden-Mason L, Shaw GM, Khetani S, Rosen H. Transmitted/founder hepatitis C viruses induce cell-type- and genotype-specific differences in innate signaling within the liver. MBio. 2015 Feb 24; 6(2):e02510. PMID: 25714713; PMCID: PMC4357998.
    23. Giugliano S, Kriss M, Golden-Mason L, Dobrinskikh E, Stone AE, Soto-Gutierrez A, Mitchell A, Khetani SR, Yamane D, Stoddard M, Li H, Shaw GM, Edwards MG, Lemon SM, Gale M, Shah VH, Rosen H. Hepatitis C virus infection induces autocrine interferon signaling by human liver endothelial cells and release of exosomes, which inhibits viral replication. Gastroenterology. 2015 Feb; 148(2):392-402.e13. PMID: 25447848.
      View in: PubMed
    24. Golden-Mason L, Hahn YS, Strong M, Cheng L, Rosen H. Extracellular HCV-core protein induces an immature regulatory phenotype in NK cells: implications for outcome of acute infection. PLoS One. 2014; 9(7):e103219. PMID: 25076408; PMCID: PMC4116173.
    25. Stone AE, Mitchell A, Brownell J, Miklin DJ, Golden-Mason L, Polyak SJ, Gale MJ, Rosen H. Hepatitis C virus core protein inhibits interferon production by a human plasmacytoid dendritic cell line and dysregulates interferon regulatory factor-7 and signal transducer and activator of transcription (STAT) 1 protein expression. PLoS One. 2014; 9(5):e95627. PMID: 24788809; PMCID: PMC4006833.
    26. Ishimoto T, Lanaspa MA, Rivard CJ, Roncal-Jimenez CA, Orlicky DJ, Cicerchi C, McMahan RH, Abdelmalek MF, Rosen H, Jackman MR, MacLean PS, Diggle CP, Asipu A, Inaba S, Kosugi T, Sato W, Maruyama S, Sánchez-Lozada LG, Sautin YY, Hill JO, Bonthron DT, Johnson RJ. High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase. Hepatology. 2013 Nov; 58(5):1632-43. PMID: 23813872; PMCID: PMC3894259.
    27. Rosen H. Emerging concepts in immunity to hepatitis C virus infection. J Clin Invest. 2013 Oct; 123(10):4121-30. PMID: 24084744; PMCID: PMC3784533.
    28. Golden-Mason L, Rosen H. Natural killer cells: multifaceted players with key roles in hepatitis C immunity. Immunol Rev. 2013 Sep; 255(1):68-81. PMID: 23947348; PMCID: PMC3765000.
    29. Stone AE, Giugliano S, Schnell G, Cheng L, Leahy KF, Golden-Mason L, Gale M, Rosen H. Hepatitis C virus pathogen associated molecular pattern (PAMP) triggers production of lambda-interferons by human plasmacytoid dendritic cells. PLoS Pathog. 2013; 9(4):e1003316. PMID: 23637605; PMCID: PMC3630164.
    30. Lee HC, Sung SS, Krueger PD, Jo YA, Rosen H, Ziegler SF, Hahn YS. Hepatitis C virus promotes T-helper (Th)17 responses through thymic stromal lymphopoietin production by infected hepatocytes. Hepatology. 2013 Apr; 57(4):1314-24. PMID: 23150092; PMCID: PMC3582737.
    31. McMahan RH, Wang XX, Cheng LL, Krisko T, Smith M, El Kasmi K, Pruzanski M, Adorini L, Golden-Mason L, Levi M, Rosen H. Bile acid receptor activation modulates hepatic monocyte activity and improves nonalcoholic fatty liver disease. J Biol Chem. 2013 Apr 26; 288(17):11761-70. PMID: 23460643; PMCID: PMC3636865.
    32. Duggal P, Thio CL, Wojcik GL, Goedert JJ, Mangia A, Latanich R, Kim AY, Lauer GM, Chung RT, Peters MG, Kirk GD, Mehta SH, Cox AL, Khakoo SI, Alric L, Cramp ME, Donfield SM, Edlin BR, Tobler LH, Busch MP, Alexander G, Rosen H, Gao X, Abdel-Hamid M, Apps R, Carrington M, Thomas DL. Genome-wide association study of spontaneous resolution of hepatitis C virus infection: data from multiple cohorts. Ann Intern Med. 2013 Feb 19; 158(4):235-45. PMID: 23420232; PMCID: PMC3638215.
    33. Golden-Mason L, McMahan RH, Strong M, Reisdorph R, Mahaffey S, Palmer BE, Cheng L, Kulesza C, Hirashima M, Niki T, Rosen H. Galectin-9 functionally impairs natural killer cells in humans and mice. J Virol. 2013 May; 87(9):4835-45. PMID: 23408620; PMCID: PMC3624298.
    34. Biggins SW, Trotter J, Gralla J, Burton JR, Bambha KM, Dodge J, Brocato M, Cheng L, McQueen M, Forman L, Chang M, Kam I, Everson G, Spritz RA, Klintmalm G, Rosen H. Differential effects of donor and recipient IL28B and DDX58 SNPs on severity of HCV after liver transplantation. J Hepatol. 2013 May; 58(5):969-76. PMID: 23333445; PMCID: PMC3878646.
    35. Biggins SW, Bambha KM, Terrault NA, Inadomi J, Shiboski S, Dodge JL, Gralla J, Rosen H, Roberts JP. Projected future increase in aging hepatitis C virus-infected liver transplant candidates: a potential effect of hepatocellular carcinoma. Liver Transpl. 2012 Dec; 18(12):1471-8. PMID: 23008049; PMCID: PMC3518670.
    36. Golden-Mason L, Stone AE, Bambha KM, Cheng L, Rosen H. Race- and gender-related variation in natural killer p46 expression associated with differential anti-hepatitis C virus immunity. Hepatology. 2012 Oct; 56(4):1214-22. PMID: 22505144; PMCID: PMC3458134.
    37. Tacke RS, Lee HC, Goh C, Courtney J, Polyak SJ, Rosen H, Hahn YS. Myeloid suppressor cells induced by hepatitis C virus suppress T-cell responses through the production of reactive oxygen species. Hepatology. 2012 Feb; 55(2):343-53. PMID: 21953144.
      View in: PubMed
    38. Foster RG, Golden-Mason L, Rutebemberwa A, Rosen H. Interleukin (IL)-17/IL-22-producing T cells enriched within the liver of patients with chronic hepatitis C viral (HCV) infection. Dig Dis Sci. 2012 Feb; 57(2):381-9. PMID: 22183819.
      View in: PubMed
    39. Shang S, Plymoth A, Ge S, Feng Z, Rosen H, Sangrajrang S, Hainaut P, Marrero JA, Beretta L. Identification of osteopontin as a novel marker for early hepatocellular carcinoma. Hepatology. 2012 Feb; 55(2):483-90. PMID: 21953299; PMCID: PMC3914762.
    40. Golden-Mason L, Bambha KM, Cheng L, Howell CD, Taylor MW, Clark PJ, Afdhal N, Rosen H. Natural killer inhibitory receptor expression associated with treatment failure and interleukin-28B genotype in patients with chronic hepatitis C. Hepatology. 2011 Nov; 54(5):1559-69. PMID: 21983945; PMCID: PMC3206734.
    41. Rosen H. Clinical practice. Chronic hepatitis C infection. N Engl J Med. 2011 Jun 23; 364(25):2429-38. PMID: 21696309.
      View in: PubMed
    42. Li H, Hughes AL, Bano N, McArdle S, Livingston S, Deubner H, McMahon BJ, Townshend-Bulson L, McMahan R, Rosen H, Gretch DR. Genetic diversity of near genome-wide hepatitis C virus sequences during chronic infection: evidence for protein structural conservation over time. PLoS One. 2011 May 05; 6(5):e19562. PMID: 21573177; PMCID: PMC3088699.
    43. McMahan RH, Golden-Mason L, Nishimura MI, McMahon BJ, Kemper M, Allen TM, Gretch DR, Rosen H. Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity. J Clin Invest. 2010 Dec; 120(12):4546-57. PMID: 21084749; PMCID: PMC2994339.
    44. Golden-Mason L, Cox AL, Randall JA, Cheng L, Rosen H. Increased natural killer cell cytotoxicity and NKp30 expression protects against hepatitis C virus infection in high-risk individuals and inhibits replication in vitro. Hepatology. 2010 Nov; 52(5):1581-9. PMID: 20812318; PMCID: PMC2967665.
    45. Hurtado CW, Golden-Mason L, Brocato M, Krull M, Narkewicz MR, Rosen H. Innate immune function in placenta and cord blood of hepatitis C--seropositive mother-infant dyads. PLoS One. 2010 Aug 30; 5(8):e12232. PMID: 20814429.
      View in: PubMed
    46. Zhang Y, Liu Y, Moxley KM, Golden-Mason L, Hughes MG, Liu T, Heemskerk MH, Rosen H, Nishimura MI. Transduction of human T cells with a novel T-cell receptor confers anti-HCV reactivity. PLoS Pathog. 2010 Jul 29; 6(7):e1001018. PMID: 20686664; PMCID: PMC2912399.
    47. Mosbruger TL, Duggal P, Goedert JJ, Kirk GD, Hoots WK, Tobler LH, Busch M, Peters MG, Rosen H, Thomas DL, Thio CL. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. J Infect Dis. 2010 May 01; 201(9):1371-80. PMID: 20331378; PMCID: PMC2853721.
    48. Tang X, Wagoner J, Negash A, Austin M, McLauchlan J, Hahn YS, Rosen H, Polyak SJ. Functional characterization of core genes from patients with acute hepatitis C virus infection. J Infect Dis. 2010 Mar 15; 201(6):912-22. PMID: 20170366; PMCID: PMC2827820.
    49. Mengshol JA, Golden-Mason L, Arikawa T, Smith M, Niki T, McWilliams R, Randall JA, McMahan R, Zimmerman MA, Rangachari M, Dobrinskikh E, Busson P, Polyak SJ, Hirashima M, Rosen H. A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in hepatitis C infection. PLoS One. 2010 Mar 04; 5(3):e9504. PMID: 20209097; PMCID: PMC2831996.
    50. Eberlein J, Nguyen TT, Victorino F, Golden-Mason L, Rosen H, Homann D. Comprehensive assessment of chemokine expression profiles by flow cytometry. J Clin Invest. 2010 Mar; 120(3):907-23. PMID: 20197626; PMCID: PMC2827956.
    51. Neumann-Haefelin C, Timm J, Schmidt J, Kersting N, Fitzmaurice K, Oniangue-Ndza C, Kemper MN, Humphreys I, McKiernan S, Kelleher D, Lohmann V, Bowness P, Huzly D, Rosen H, Kim AY, Lauer GM, Allen TM, Barnes E, Roggendorf M, Blum HE, Thimme R. Protective effect of human leukocyte antigen B27 in hepatitis C virus infection requires the presence of a genotype-specific immunodominant CD8+ T-cell epitope. Hepatology. 2010 Jan; 51(1):54-62. PMID: 20034048; PMCID: PMC4396188.
    52. Hughes MG, Rosen H. Human liver transplantation as a model to study hepatitis C virus pathogenesis. Liver Transpl. 2009 Nov; 15(11):1395-411. PMID: 19877210; PMCID: PMC2954677.
    53. Thomas DL, Thio CL, Martin MP, Qi Y, Ge D, O'Huigin C, Kidd J, Kidd K, Khakoo SI, Alexander G, Goedert JJ, Kirk GD, Donfield SM, Rosen H, Tobler LH, Busch MP, McHutchison JG, Goldstein DB, Carrington M. Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature. 2009 Oct 08; 461(7265):798-801. PMID: 19759533; PMCID: PMC3172006.
    54. Golden-Mason L, Palmer BE, Kassam N, Townshend-Bulson L, Livingston S, McMahon BJ, Castelblanco N, Kuchroo V, Gretch DR, Rosen H. Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells. J Virol. 2009 Sep; 83(18):9122-30. PMID: 19587053; PMCID: PMC2738247.
    55. Cummings KL, Rosen H, Hahn YS. Frequency of gC1qR+CD4+ T cells increases during acute hepatitis C virus infection and remains elevated in patients with chronic infection. Clin Immunol. 2009 Sep; 132(3):401-11. PMID: 19473882; PMCID: PMC2720442.
    56. Kuntzen T, Timm J, Berical A, Lennon N, Berlin AM, Young SK, Lee B, Heckerman D, Carlson J, Reyor LL, Kleyman M, McMahon CM, Birch C, Schulze Zur Wiesch J, Ledlie T, Koehrsen M, Kodira C, Roberts AD, Lauer GM, Rosen H, Bihl F, Cerny A, Spengler U, Liu Z, Kim AY, Xing Y, Schneidewind A, Madey MA, Fleckenstein JF, Park VM, Galagan JE, Nusbaum C, Walker BD, Lake-Bakaar GV, Daar ES, Jacobson IM, Gomperts ED, Edlin BR, Donfield SM, Chung RT, Talal AH, Marion T, Birren BW, Henn MR, Allen TM. Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naïve patients. Hepatology. 2008 Dec; 48(6):1769-78. PMID: 19026009; PMCID: PMC2645896.
    57. Pandey JP, Namboodiri AM, Luo Y, Wu Y, Elston RC, Thomas DL, Rosen H, Goedert JJ. Genetic markers of IgG influence the outcome of infection with hepatitis C virus. J Infect Dis. 2008 Nov 01; 198(9):1334-6. PMID: 18855559.
      View in: PubMed
    58. Burton JR, Klarquist J, Im K, Smyk-Pearson S, Golden-Mason L, Castelblanco N, Terrault N, Rosen H. Prospective analysis of effector and regulatory CD4+ T cells in chronic HCV patients undergoing combination antiviral therapy. J Hepatol. 2008 Sep; 49(3):329-38. PMID: 18644644.
      View in: PubMed
    59. Rosen H. Transplantation immunology: what the clinician needs to know for immunotherapy. Gastroenterology. 2008 May; 134(6):1789-801. PMID: 18471555.
      View in: PubMed
    60. Golden-Mason L, Klarquist J, Wahed AS, Rosen H. Cutting edge: programmed death-1 expression is increased on immunocytes in chronic hepatitis C virus and predicts failure of response to antiviral therapy: race-dependent differences. J Immunol. 2008 Mar 15; 180(6):3637-41. PMID: 18322167.
      View in: PubMed
    61. Rosen H, Doherty DG, Madrigal-Estebas L, O'Farrelly C, Golden-Mason L. Pretransplantation CD56(+) innate lymphocyte populations associated with severity of hepatitis C virus recurrence. Liver Transpl. 2008 Jan; 14(1):31-40. PMID: 18161829.
      View in: PubMed
    62. Smyk-Pearson S, Golden-Mason L, Klarquist J, Burton JR, Tester IA, Wang CC, Culbertson N, Vandenbark AA, Rosen H. Functional suppression by FoxP3+CD4+CD25(high) regulatory T cells during acute hepatitis C virus infection. J Infect Dis. 2008 Jan 01; 197(1):46-57. PMID: 18171284.
      View in: PubMed
    63. Smyk-Pearson S, Tester IA, Klarquist J, Palmer BE, Pawlotsky JM, Golden-Mason L, Rosen H. Spontaneous recovery in acute human hepatitis C virus infection: functional T-cell thresholds and relative importance of CD4 help. J Virol. 2008 Feb; 82(4):1827-37. PMID: 18045940; PMCID: PMC2258714.
    64. Mengshol JA, Golden-Mason L, Rosen H. Mechanisms of Disease: HCV-induced liver injury. Nat Clin Pract Gastroenterol Hepatol. 2007 Nov; 4(11):622-34. PMID: 17978819.
      View in: PubMed
    65. Wang CC, Krantz E, Klarquist J, Krows M, McBride L, Scott EP, Shaw-Stiffel T, Weston SJ, Thiede H, Wald A, Rosen H. Acute hepatitis C in a contemporary US cohort: modes of acquisition and factors influencing viral clearance. J Infect Dis. 2007 Nov 15; 196(10):1474-82. PMID: 18008226.
      View in: PubMed
    66. Rosen H, Weston SJ, Im K, Yang H, Burton JR, Erlich H, Klarquist J, Belle SH. Selective decrease in hepatitis C virus-specific immunity among African Americans and outcome of antiviral therapy. Hepatology. 2007 Aug; 46(2):350-8. PMID: 17659573.
      View in: PubMed
    67. Golden-Mason L, Palmer B, Klarquist J, Mengshol JA, Castelblanco N, Rosen H. Upregulation of PD-1 expression on circulating and intrahepatic hepatitis C virus-specific CD8+ T cells associated with reversible immune dysfunction. J Virol. 2007 Sep; 81(17):9249-58. PMID: 17567698; PMCID: PMC1951397.
    68. Golden-Mason L, Castelblanco N, O'Farrelly C, Rosen H. Phenotypic and functional changes of cytotoxic CD56pos natural T cells determine outcome of acute hepatitis C virus infection. J Virol. 2007 Sep; 81(17):9292-8. PMID: 17553896; PMCID: PMC1951454.
    69. Wertheimer AM, Polyak SJ, Leistikow R, Rosen H. Engulfment of apoptotic cells expressing HCV proteins leads to differential chemokine expression and STAT signaling in human dendritic cells. Hepatology. 2007 Jun; 45(6):1422-32. PMID: 17538964.
      View in: PubMed
    70. Zaman A, Rosen H, Ingram K, Corless CL, Oh E, Smith K. Assessment of FIBROSpect II to detect hepatic fibrosis in chronic hepatitis C patients. Am J Med. 2007 Mar; 120(3):280.e9-14. PMID: 17349453.
      View in: PubMed
    71. Huang Y, Yang H, Borg BB, Su X, Rhodes SL, Yang K, Tong X, Tang G, Howell CD, Rosen H, Thio CL, Thomas DL, Alter HJ, Sapp RK, Liang TJ. A functional SNP of interferon-gamma gene is important for interferon-alpha-induced and spontaneous recovery from hepatitis C virus infection. Proc Natl Acad Sci U S A. 2007 Jan 16; 104(3):985-90. PMID: 17215375; PMCID: PMC1783426.
    72. Golden-Mason L, Burton JR, Castelblanco N, Klarquist J, Benlloch S, Wang C, Rosen H. Loss of IL-7 receptor alpha-chain (CD127) expression in acute HCV infection associated with viral persistence. Hepatology. 2006 Nov; 44(5):1098-109. PMID: 17058243.
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    73. Burton JR, Rosen H. Acute rejection in HCV-infected liver transplant recipients: The great conundrum. Liver Transpl. 2006 Nov; 12(11 Suppl 2):S38-47. PMID: 17051562.
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    74. Smyk-Pearson S, Tester IA, Lezotte D, Sasaki AW, Lewinsohn DM, Rosen H. Differential antigenic hierarchy associated with spontaneous recovery from hepatitis C virus infection: implications for vaccine design. J Infect Dis. 2006 Aug 15; 194(4):454-63. PMID: 16845628.
      View in: PubMed
    75. Burton JR, Rosen H. Diagnosis and management of allograft failure. Clin Liver Dis. 2006 May; 10(2):407-35, x. PMID: 16971269.
      View in: PubMed
    76. Callender GG, Rosen H, Roszkowski JJ, Lyons GE, Li M, Moore T, Brasic N, McKee MD, Nishimura MI. Identification of a hepatitis C virus-reactive T cell receptor that does not require CD8 for target cell recognition. Hepatology. 2006 May; 43(5):973-81. PMID: 16628627.
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    77. Golden-Mason L, Rosen H. Natural killer cells: primary target for hepatitis C virus immune evasion strategies? Liver Transpl. 2006 Mar; 12(3):363-72. PMID: 16498647.
      View in: PubMed
    78. Tester I, Smyk-Pearson S, Wang P, Wertheimer A, Yao E, Lewinsohn DM, Tavis JE, Rosen H. Immune evasion versus recovery after acute hepatitis C virus infection from a shared source. J Exp Med. 2005 Jun 06; 201(11):1725-31. PMID: 15939788; PMCID: PMC2213272.
    79. Weston SJ, Leistikow RL, Reddy KR, Torres M, Wertheimer AM, Lewinsohn DM, Chou S, Davey MP, Corless C, O'Farrelly C, Nelson DR, Rosen H. Reconstitution of hepatitis C virus-specific T-cellmediated immunity after liver transplantation. Hepatology. 2005 Jan; 41(1):72-81. PMID: 15619226.
      View in: PubMed
    80. Cabrera R, Tu Z, Xu Y, Firpi RJ, Rosen H, Liu C, Nelson DR. An immunomodulatory role for CD4(+)CD25(+) regulatory T lymphocytes in hepatitis C virus infection. Hepatology. 2004 Nov; 40(5):1062-71. PMID: 15486925.
      View in: PubMed
    81. Burton JR, Sonnenberg A, Rosen H. Retransplantation for recurrent hepatitis C in the MELD era: maximizing utility. Liver Transpl. 2004 Oct; 10(10 Suppl 2):S59-64. PMID: 15382221.
      View in: PubMed
    82. Wertheimer AM, Bakke A, Rosen H. Direct enumeration and functional assessment of circulating dendritic cells in patients with liver disease. Hepatology. 2004 Aug; 40(2):335-45. PMID: 15368438.
      View in: PubMed
    83. Austin GL, Sasaki AW, Zaman A, Rabkin JM, Olyaei A, Ruimy R, Orloff SL, Ham J, Rosen H. Comparative analysis of outcome following liver transplantation in US veterans. Am J Transplant. 2004 May; 4(5):788-95. PMID: 15084176.
      View in: PubMed
    84. Zaman A, Hapke RJ, Flora K, Rosen H, Benner KG. Changing compliance to the American College of Gastroenterology guidelines for the management of variceal hemorrhage: a regional survey. Am J Gastroenterol. 2004 Apr; 99(4):645-9. PMID: 15089896.
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    85. Chan SE, Schwartz JM, Rosen H. Treatment of hepatitis C in solid organ transplantation. Drugs. 2004; 64(5):489-98. PMID: 14977386.
      View in: PubMed
    86. Simon BE, Cornell KA, Clark TR, Chou S, Rosen H, Barry RA. DNA vaccination protects mice against challenge with Listeria monocytogenes expressing the hepatitis C virus NS3 protein. Infect Immun. 2003 Nov; 71(11):6372-80. PMID: 14573658; PMCID: PMC219586.
    87. Gopal DV, Corless CL, Rabkin JM, Olyaei AJ, Rosen H. Graft failure from severe recurrent primary sclerosing cholangitis following orthotopic liver transplantation. J Clin Gastroenterol. 2003 Oct; 37(4):344-7. PMID: 14506394.
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    88. Rosen H, Prieto M, Casanovas-Taltavull T, Cuervas-Mons V, Guckelberger O, Muiesan P, Strong RW, Bechstein WO, O'grady J, Zaman A, Chan B, Berenguer J, Williams R, Heaton N, Neuhaus P. Validation and refinement of survival models for liver retransplantation. Hepatology. 2003 Aug; 38(2):460-9. PMID: 12883491.
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    89. Wertheimer AM, Miner C, Lewinsohn DM, Sasaki AW, Kaufman E, Rosen H. Novel CD4+ and CD8+ T-cell determinants within the NS3 protein in subjects with spontaneously resolved HCV infection. Hepatology. 2003 Mar; 37(3):577-89. PMID: 12601356.
      View in: PubMed
    90. Rosen H, Marousek G, Chou S. A longitudinal analysis of T-cell epitope-coding regions of hepatitis C virus after liver transplantation. Transplantation. 2002 Jul 27; 74(2):209-16. PMID: 12151733.
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    91. Rosen H, Schwartz JM. Hepatitis C quasispecies and severity of recurrence: cause, consequence, or coincidence? Liver Transpl. 2002 Jul; 8(7):646-8. PMID: 12089722.
      View in: PubMed
    92. Rosen H, Ribeiro RR, Weinberger L, Wolf S, Chung M, Gretch DR, Perelson AS. Early hepatitis C viral kinetics correlate with long-term outcome in patients receiving high dose induction followed by combination interferon and ribavirin therapy. J Hepatol. 2002 Jul; 37(1):124-30. PMID: 12076871.
      View in: PubMed
    93. Rosen H, Miner C, Sasaki AW, Lewinsohn DM, Conrad AJ, Bakke A, Bouwer HG, Hinrichs DJ. Frequencies of HCV-specific effector CD4+ T cells by flow cytometry: correlation with clinical disease stages. Hepatology. 2002 Jan; 35(1):190-8. PMID: 11786976.
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