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Hugo Rosen, MD

Title(s)Professor and Chair, Department of Medicine
SchoolKeck School of Medicine of USC
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    Other Positions
    Title(s)Kenneth T. Norris, Jr., Chair in Medicine


    Collapse Overview 
    Collapse Overview
    Hugo R. Rosen, MD is the Norris Chair of Medicine and Professor of Medicine, Immunology, and Molecular Microbiology.

    Rosen is a prolific physician-scientist with more than 180 original peer-reviewed manuscripts investigating the cellular and molecular underpinnings of a wide spectrum of innate and adaptive immune responses and developing novel paradigms in liver diseases. He has been the principal investigator of multiple National Institutes of Health grants (including two active RO1 grants), Center Grants, three T32 training grants and five VA Merit grants. He is an elected member of the American Society of Clinical Investigation (elected in 2008) and the American Association of Physicians. He has also received research funding from the American Society of Transplantation and American Association for the Study of Liver Diseases, having been named “Fellow” in the inaugural class of both societies. He currently serves as deputy editor of the journal Hepatology. He completed his internship and residency in internal medicine at Beth Israel Deaconess Medical Center, Harvard Medical School, followed by a fellowship in gastroenterology and transplant hepatology at UCLA. He will manage patients with acute and chronic liver disease at the Medical Center of USC and LAC+USC Medical Center.

    Collapse Research 
    Collapse Research Activities and Funding
    Restoration of immunity and function with DAA treatment in HCV infection
    NIH/NIAID R01AI120622Feb 14, 2017 - Jan 31, 2021
    Role: Principal Investigator
    Mechanisms of hepatic innate immune activation by HCV
    NIH/NIAID R01AI127463Dec 15, 2016 - Nov 30, 2021
    Role: Co-Principal Investigator
    INNATE AND ADAPTIVE IMMUNITY TO HCV IN HUMAN PREGNANCY
    NIH/NICHD R01HD075549Feb 7, 2014 - Jan 31, 2019
    Role: Principal Investigator
    Novel Aspects of Hepatic Innate and Adaptive Immunity to HCV Infection
    VA I01BX002201Jan 1, 2014 - Dec 31, 2017
    Role: Principal Investigator
    Hepatitis C viral sensing by non-parenchymal liver cells (NPC)
    NIH/NIAID R21AI103361May 15, 2013 - Apr 30, 2015
    Role: Principal Investigator
    HEPATITIS C VIRAL INFECTION IN HUMAN PREGNANCY
    NIH/NIAID R56AI100991Sep 20, 2012 - Feb 28, 2014
    Role: Principal Investigator
    Functional attributes of CD8+ T cells in recovery of hepatitis C virus infection
    VA I01CX000111Oct 1, 2009 - Sep 30, 2013
    Role: Principal Investigator
    Midcareer Investigator Award in Patient-Oriented Research (K24)
    NIH/NIAID K24AI083742Sep 18, 2009 - Jul 31, 2014
    Role: Principal Investigator
    Innate Immune Responses During Therapy for Chronic HCV
    NIH/NIDDK R01DK071560Sep 30, 2005 - Jul 31, 2010
    Role: Principal Investigator
    Colorado Hepatitis C Cooperative Research Center
    NIH/NIAID U19AI066328Jul 1, 2005 - Aug 31, 2015
    Role: Principal Investigator
    Immune Responses in Acute Hepatitis C Infection
    NIH/NIDDK R01DK060590Sep 15, 2002 - Aug 31, 2011
    Role: Principal Investigator
    Cellular Immune Mechanisms of Resistance to HCV Therapy
    NIH/NIDDK U01DK060342Sep 30, 2001 - Apr 30, 2007
    Role: Principal Investigator
    USC Research Center for Liver Disease
    NIH/NIDDK P30DK048522Mar 1, 1995 - Feb 28, 2021
    Role: Principal Investigator
    Gastrointestinal Diseases Training Grant
    NIH/NIDDK T32DK007038Jul 1, 1975 - Jun 30, 2021
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Kriss M, Verna EC, Rosen HR, Lozupone CA. Functional Microbiomics in Liver Transplantation: Identifying Novel Targets for Improving Allograft Outcomes. Transplantation. 2019 Feb 04. PMID: 30507741.
      View in: PubMed
    2. Vergara C, Thio CL, Johnson E, Kral AH, O'Brien TR, Goedert JJ, Mangia A, Piazzolla V, Mehta SH, Kirk GD, Kim AY, Lauer GM, Chung RT, Cox AL, Peters MG, Khakoo SI, Alric L, Cramp ME, Donfield SM, Edlin BR, Busch MP, Alexander G, Rosen HR, Murphy EL, Latanich R, Wojcik GL, Taub MA, Valencia A, Thomas DL, Duggal P. Multi-Ancestry Genome-Wide Association Study of Spontaneous Clearance of Hepatitis C Virus. Gastroenterology. 2018 Dec 26. PMID: 30593799.
      View in: PubMed
    3. McGettigan B, McMahan R, Orlicky D, Burchill M, Danhorn T, Francis P, Cheng LL, Golden-Mason L, Jakubzick C, Rosen H. Dietary Lipids Differentially Shape NASH Progression and the Transcriptome of Kupffer Cells and Infiltrating Macrophages. Hepatology. 2018 Dec 05. PMID: 30516830.
      View in: PubMed
    4. Golden-Mason L, Rosen HR. Revisiting the Paradox of Interferon-Stimulated Gene Expression as a Predictor of Hepatitis C Virus Treatment Response, a Decade Later. Hepatology. 2018 Dec; 68(6):2053-2055. PMID: 30055107.
      View in: PubMed
    5. Golden-Mason L, McMahan RH, Kriss MS, Kilgore AL, Cheng L, Dran RJ, Wieland A, Rosen HR. Early and late changes in natural killer cells in response to ledipasvir/sofosbuvir treatment. Hepatol Commun. 2018 04; 2(4):364-375. PMID: 29619416.
      View in: PubMed
    6. Huang H, Duggal P, Thio CL, Latanich R, Goedert JJ, Mangia A, Cox AL, Kirk GD, Mehta S, Aneja J, Alric L, Donfield SM, Cramp ME, Khakoo SI, Tobler LH, Busch M, Alexander GJ, Rosen HR, Edlin BR, Segal FP, Lauer GM, Thomas DL, Daly MJ, Chung RT, Kim AY. Fine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection. Sci Rep. 2017 Nov 20; 7(1):15843. PMID: 29158528.
      View in: PubMed
    7. Cobb DA, Kim OK, Golden-Mason L, Rosen HR, Hahn YS. Hepatocyte-derived exosomes promote T follicular regulatory cell expansion during hepatitis C virus infection. Hepatology. 2018 01; 67(1):71-85. PMID: 28749570.
      View in: PubMed
    8. Burchill MA, Roby JA, Crochet N, Wind-Rotolo M, Stone AE, Edwards MG, Dran RJ, Kriss MS, Gale M, Rosen HR. Rapid reversal of innate immune dysregulation in blood of patients and livers of humanized mice with HCV following DAA therapy. PLoS One. 2017; 12(10):e0186213. PMID: 29040318.
      View in: PubMed
    9. Rosen HR, Ghany MG, Chung RT, Lok ASF. NAM 2017 report: A national plan to eliminate hepatitis B and C in the United States by 2030 and the AASLD's response. Hepatology. 2017 10; 66(4):1020-1022. PMID: 28714210.
      View in: PubMed
    10. Golden-Mason L, Rosen HR. Galectin-9: Diverse roles in hepatic immune homeostasis and inflammation. Hepatology. 2017 07; 66(1):271-279. PMID: 28195343.
      View in: PubMed
    11. Kalra A, Wedd JP, Bambha KM, Gralla J, Golden-Mason L, Collins C, Rosen HR, Biggins SW. Neutrophil-to-lymphocyte ratio correlates with proinflammatory neutrophils and predicts death in low model for end-stage liver disease patients with cirrhosis. Liver Transpl. 2017 02; 23(2):155-165. PMID: 28006875.
      View in: PubMed
    12. Giugliano S, Petroff MG, Warren BD, Jasti S, Linscheid C, Ward A, Kramer A, Dobrinskikh E, Sheiko MA, Gale M, Golden-Mason L, Winn VD, Rosen HR. Correction: Hepatitis C Virus Sensing by Human Trophoblasts Induces Innate Immune Responses and Recruitment of Maternal NK Cells: Potential Implications for Limiting Vertical Transmission. J Immunol. 2017 01 15; 198(2):972. PMID: 28069758.
      View in: PubMed
    13. Rosen HR. "Hep C, where art thou": What are the remaining (fundable) questions in hepatitis C virus research? Hepatology. 2017 01; 65(1):341-349. PMID: 27640881.
      View in: PubMed
    14. McMahan RH, Porsche CE, Edwards MG, Rosen HR. Free Fatty Acids Differentially Downregulate Chemokines in Liver Sinusoidal Endothelial Cells: Insights into Non-Alcoholic Fatty Liver Disease. PLoS One. 2016; 11(7):e0159217. PMID: 27454769; PMCID: PMC4959750.
    15. White JT, Cross EW, Burchill MA, Danhorn T, McCarter MD, Rosen HR, O'Connor B, Kedl RM. Virtual memory T cells develop and mediate bystander protective immunity in an IL-15-dependent manner. Nat Commun. 2016 Apr 21; 7:11291. PMID: 27097762.
      View in: PubMed
    16. Spear TT, Riley TP, Lyons GE, Callender GG, Roszkowski JJ, Wang Y, Simms PE, Scurti GM, Foley KC, Murray DC, Hellman LM, McMahan RH, Iwashima M, Garrett-Mayer E, Rosen HR, Baker BM, Nishimura MI. Hepatitis C virus-cross-reactive TCR gene-modified T cells: a model for immunotherapy against diseases with genomic instability. J Leukoc Biol. 2016 09; 100(3):545-57. PMID: 26921345; PMCID: PMC4982612 [Available on 09/01/17].
    17. Goh CC, Roggerson KM, Lee HC, Golden-Mason L, Rosen HR, Hahn YS. Hepatitis C Virus-Induced Myeloid-Derived Suppressor Cells Suppress NK Cell IFN-? Production by Altering Cellular Metabolism via Arginase-1. J Immunol. 2016 Mar 01; 196(5):2283-92. PMID: 26826241; PMCID: PMC4761460 [Available on 03/01/17].
    18. Sheiko MA, Golden-Mason L, Giugliano S, Hurtado CW, Mack CL, Narkewicz MR, Rosen HR. CD4+ and CD8+ T Cell Activation in Children with Hepatitis C. J Pediatr. 2016 Mar; 170:142-8.e1. PMID: 26743497; PMCID: PMC4833455 [Available on 03/01/17].
    19. Rosen HR, Golden-Mason L, Daly AK, Yang I, Day CP. Variants in the LGALS9 Gene Are Associated With Development of Liver Disease in Heavy Consumers of Alcohol. Clin Gastroenterol Hepatol. 2016 May; 14(5):762-8.e1. PMID: 26598225.
      View in: PubMed
    20. Rosen HR, Biggins SW, Niki T, Gralla J, Hillman H, Hirashima M, Schilsky M, Lee WM. Association Between Plasma Level of Galectin-9 and Survival of Patients With Drug-Induced Acute Liver Failure. Clin Gastroenterol Hepatol. 2016 Apr; 14(4):606-612.e3. PMID: 26499927.
      View in: PubMed
    21. Harwood NM, Golden-Mason L, Cheng L, Rosen HR, Mengshol JA. HCV-infected cells and differentiation increase monocyte immunoregulatory galectin-9 production. J Leukoc Biol. 2016 Mar; 99(3):495-503. PMID: 26475932.
      View in: PubMed
    22. Giugliano S, Petroff MG, Warren BD, Jasti S, Linscheid C, Ward A, Kramer A, Dobrinskikh E, Sheiko MA, Gale M, Golden-Mason L, Winn VD, Rosen HR. Hepatitis C Virus Sensing by Human Trophoblasts Induces Innate Immune Responses and Recruitment of Maternal NK Cells: Potential Implications for Limiting Vertical Transmission. J Immunol. 2015 10 15; 195(8):3737-47. PMID: 26342030; PMCID: PMC4592818 [Available on 10/15/16].
    23. Golden-Mason L, Waasdorp Hurtado CE, Cheng L, Rosen HR. Hepatitis C viral infection is associated with activated cytolytic natural killer cells expressing high levels of T cell immunoglobulin- and mucin-domain-containing molecule-3. Clin Immunol. 2015 May; 158(1):114-25. PMID: 25797693.
      View in: PubMed
    24. Mitchell AM, Stone AE, Cheng L, Ballinger K, Edwards MG, Stoddard M, Li H, Golden-Mason L, Shaw GM, Khetani S, Rosen HR. Transmitted/founder hepatitis C viruses induce cell-type- and genotype-specific differences in innate signaling within the liver. MBio. 2015 Feb 24; 6(2):e02510. PMID: 25714713; PMCID: PMC4357998.
    25. Giugliano S, Kriss M, Golden-Mason L, Dobrinskikh E, Stone AE, Soto-Gutierrez A, Mitchell A, Khetani SR, Yamane D, Stoddard M, Li H, Shaw GM, Edwards MG, Lemon SM, Gale M, Shah VH, Rosen HR. Hepatitis C virus infection induces autocrine interferon signaling by human liver endothelial cells and release of exosomes, which inhibits viral replication. Gastroenterology. 2015 Feb; 148(2):392-402.e13. PMID: 25447848.
      View in: PubMed
    26. Golden-Mason L, Hahn YS, Strong M, Cheng L, Rosen HR. Extracellular HCV-core protein induces an immature regulatory phenotype in NK cells: implications for outcome of acute infection. PLoS One. 2014; 9(7):e103219. PMID: 25076408; PMCID: PMC4116173.
    27. Stone AE, Mitchell A, Brownell J, Miklin DJ, Golden-Mason L, Polyak SJ, Gale MJ, Rosen HR. Hepatitis C virus core protein inhibits interferon production by a human plasmacytoid dendritic cell line and dysregulates interferon regulatory factor-7 and signal transducer and activator of transcription (STAT) 1 protein expression. PLoS One. 2014; 9(5):e95627. PMID: 24788809; PMCID: PMC4006833.
    28. Ishimoto T, Lanaspa MA, Rivard CJ, Roncal-Jimenez CA, Orlicky DJ, Cicerchi C, McMahan RH, Abdelmalek MF, Rosen HR, Jackman MR, MacLean PS, Diggle CP, Asipu A, Inaba S, Kosugi T, Sato W, Maruyama S, Sánchez-Lozada LG, Sautin YY, Hill JO, Bonthron DT, Johnson RJ. High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase. Hepatology. 2013 Nov; 58(5):1632-43. PMID: 23813872; PMCID: PMC3894259.
    29. Rosen HR. Emerging concepts in immunity to hepatitis C virus infection. J Clin Invest. 2013 Oct; 123(10):4121-30. PMID: 24084744; PMCID: PMC3784533.
    30. Golden-Mason L, Rosen HR. Natural killer cells: multifaceted players with key roles in hepatitis C immunity. Immunol Rev. 2013 Sep; 255(1):68-81. PMID: 23947348; PMCID: PMC3765000.
    31. Stone AE, Giugliano S, Schnell G, Cheng L, Leahy KF, Golden-Mason L, Gale M, Rosen HR. Hepatitis C virus pathogen associated molecular pattern (PAMP) triggers production of lambda-interferons by human plasmacytoid dendritic cells. PLoS Pathog. 2013; 9(4):e1003316. PMID: 23637605; PMCID: PMC3630164.
    32. Lee HC, Sung SS, Krueger PD, Jo YA, Rosen HR, Ziegler SF, Hahn YS. Hepatitis C virus promotes T-helper (Th)17 responses through thymic stromal lymphopoietin production by infected hepatocytes. Hepatology. 2013 Apr; 57(4):1314-24. PMID: 23150092; PMCID: PMC3582737.
    33. McMahan RH, Wang XX, Cheng LL, Krisko T, Smith M, El Kasmi K, Pruzanski M, Adorini L, Golden-Mason L, Levi M, Rosen HR. Bile acid receptor activation modulates hepatic monocyte activity and improves nonalcoholic fatty liver disease. J Biol Chem. 2013 Apr 26; 288(17):11761-70. PMID: 23460643; PMCID: PMC3636865.
    34. Duggal P, Thio CL, Wojcik GL, Goedert JJ, Mangia A, Latanich R, Kim AY, Lauer GM, Chung RT, Peters MG, Kirk GD, Mehta SH, Cox AL, Khakoo SI, Alric L, Cramp ME, Donfield SM, Edlin BR, Tobler LH, Busch MP, Alexander G, Rosen HR, Gao X, Abdel-Hamid M, Apps R, Carrington M, Thomas DL. Genome-wide association study of spontaneous resolution of hepatitis C virus infection: data from multiple cohorts. Ann Intern Med. 2013 Feb 19; 158(4):235-45. PMID: 23420232; PMCID: PMC3638215.
    35. Golden-Mason L, McMahan RH, Strong M, Reisdorph R, Mahaffey S, Palmer BE, Cheng L, Kulesza C, Hirashima M, Niki T, Rosen HR. Galectin-9 functionally impairs natural killer cells in humans and mice. J Virol. 2013 May; 87(9):4835-45. PMID: 23408620; PMCID: PMC3624298.
    36. Biggins SW, Trotter J, Gralla J, Burton JR, Bambha KM, Dodge J, Brocato M, Cheng L, McQueen M, Forman L, Chang M, Kam I, Everson G, Spritz RA, Klintmalm G, Rosen HR. Differential effects of donor and recipient IL28B and DDX58 SNPs on severity of HCV after liver transplantation. J Hepatol. 2013 May; 58(5):969-76. PMID: 23333445; PMCID: PMC3878646.
    37. Golden-Mason L, Stone AE, Bambha KM, Cheng L, Rosen HR. Race- and gender-related variation in natural killer p46 expression associated with differential anti-hepatitis C virus immunity. Hepatology. 2012 Oct; 56(4):1214-22. PMID: 22505144; PMCID: PMC3458134.
    38. Tacke RS, Lee HC, Goh C, Courtney J, Polyak SJ, Rosen HR, Hahn YS. Myeloid suppressor cells induced by hepatitis C virus suppress T-cell responses through the production of reactive oxygen species. Hepatology. 2012 Feb; 55(2):343-53. PMID: 21953144.
      View in: PubMed
    39. Rutebemberwa A, Rosen HR. Of mice and men, calcineurin inhibitors and hepatitis C. Liver Transpl. 2012 Jan; 18(1):1-4. PMID: 22034173.
      View in: PubMed
    40. Foster RG, Golden-Mason L, Rutebemberwa A, Rosen HR. Interleukin (IL)-17/IL-22-producing T cells enriched within the liver of patients with chronic hepatitis C viral (HCV) infection. Dig Dis Sci. 2012 Feb; 57(2):381-9. PMID: 22183819.
      View in: PubMed
    41. Shang S, Plymoth A, Ge S, Feng Z, Rosen HR, Sangrajrang S, Hainaut P, Marrero JA, Beretta L. Identification of osteopontin as a novel marker for early hepatocellular carcinoma. Hepatology. 2012 Feb; 55(2):483-90. PMID: 21953299; PMCID: PMC3914762.
    42. Golden-Mason L, Bambha KM, Cheng L, Howell CD, Taylor MW, Clark PJ, Afdhal N, Rosen HR. Natural killer inhibitory receptor expression associated with treatment failure and interleukin-28B genotype in patients with chronic hepatitis C. Hepatology. 2011 Nov; 54(5):1559-69. PMID: 21983945; PMCID: PMC3206734.
    43. Rosen HR. Clinical practice. Chronic hepatitis C infection. N Engl J Med. 2011 Jun 23; 364(25):2429-38. PMID: 21696309.
      View in: PubMed
    44. Li H, Hughes AL, Bano N, McArdle S, Livingston S, Deubner H, McMahon BJ, Townshend-Bulson L, McMahan R, Rosen HR, Gretch DR. Genetic diversity of near genome-wide hepatitis C virus sequences during chronic infection: evidence for protein structural conservation over time. PLoS One. 2011 May 05; 6(5):e19562. PMID: 21573177; PMCID: PMC3088699.
    45. McMahan RH, Golden-Mason L, Nishimura MI, McMahon BJ, Kemper M, Allen TM, Gretch DR, Rosen HR. Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity. J Clin Invest. 2010 Dec; 120(12):4546-57. PMID: 21084749; PMCID: PMC2994339.
    46. Golden-Mason L, Cox AL, Randall JA, Cheng L, Rosen HR. Increased natural killer cell cytotoxicity and NKp30 expression protects against hepatitis C virus infection in high-risk individuals and inhibits replication in vitro. Hepatology. 2010 Nov; 52(5):1581-9. PMID: 20812318; PMCID: PMC2967665.
    47. Hurtado CW, Golden-Mason L, Brocato M, Krull M, Narkewicz MR, Rosen HR. Innate immune function in placenta and cord blood of hepatitis C--seropositive mother-infant dyads. PLoS One. 2010 Aug 30; 5(8):e12232. PMID: 20814429.
      View in: PubMed
    48. Zhang Y, Liu Y, Moxley KM, Golden-Mason L, Hughes MG, Liu T, Heemskerk MH, Rosen HR, Nishimura MI. Transduction of human T cells with a novel T-cell receptor confers anti-HCV reactivity. PLoS Pathog. 2010 Jul 29; 6(7):e1001018. PMID: 20686664; PMCID: PMC2912399.
    49. Mosbruger TL, Duggal P, Goedert JJ, Kirk GD, Hoots WK, Tobler LH, Busch M, Peters MG, Rosen HR, Thomas DL, Thio CL. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. J Infect Dis. 2010 May 01; 201(9):1371-80. PMID: 20331378; PMCID: PMC2853721.
    50. Tang X, Wagoner J, Negash A, Austin M, McLauchlan J, Hahn YS, Rosen HR, Polyak SJ. Functional characterization of core genes from patients with acute hepatitis C virus infection. J Infect Dis. 2010 Mar 15; 201(6):912-22. PMID: 20170366; PMCID: PMC2827820.
    51. Mengshol JA, Golden-Mason L, Arikawa T, Smith M, Niki T, McWilliams R, Randall JA, McMahan R, Zimmerman MA, Rangachari M, Dobrinskikh E, Busson P, Polyak SJ, Hirashima M, Rosen HR. A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in hepatitis C infection. PLoS One. 2010 Mar 04; 5(3):e9504. PMID: 20209097; PMCID: PMC2831996.
    52. Eberlein J, Nguyen TT, Victorino F, Golden-Mason L, Rosen HR, Homann D. Comprehensive assessment of chemokine expression profiles by flow cytometry. J Clin Invest. 2010 Mar; 120(3):907-23. PMID: 20197626; PMCID: PMC2827956.
    53. Neumann-Haefelin C, Timm J, Schmidt J, Kersting N, Fitzmaurice K, Oniangue-Ndza C, Kemper MN, Humphreys I, McKiernan S, Kelleher D, Lohmann V, Bowness P, Huzly D, Rosen HR, Kim AY, Lauer GM, Allen TM, Barnes E, Roggendorf M, Blum HE, Thimme R. Protective effect of human leukocyte antigen B27 in hepatitis C virus infection requires the presence of a genotype-specific immunodominant CD8+ T-cell epitope. Hepatology. 2010 Jan; 51(1):54-62. PMID: 20034048; PMCID: PMC4396188.
    54. Hughes MG, Rosen HR. Human liver transplantation as a model to study hepatitis C virus pathogenesis. Liver Transpl. 2009 Nov; 15(11):1395-411. PMID: 19877210; PMCID: PMC2954677.
    55. Thomas DL, Thio CL, Martin MP, Qi Y, Ge D, O'Huigin C, Kidd J, Kidd K, Khakoo SI, Alexander G, Goedert JJ, Kirk GD, Donfield SM, Rosen HR, Tobler LH, Busch MP, McHutchison JG, Goldstein DB, Carrington M. Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature. 2009 Oct 08; 461(7265):798-801. PMID: 19759533; PMCID: PMC3172006.
    56. Golden-Mason L, Palmer BE, Kassam N, Townshend-Bulson L, Livingston S, McMahon BJ, Castelblanco N, Kuchroo V, Gretch DR, Rosen HR. Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells. J Virol. 2009 Sep; 83(18):9122-30. PMID: 19587053; PMCID: PMC2738247.
    57. Cummings KL, Rosen HR, Hahn YS. Frequency of gC1qR+CD4+ T cells increases during acute hepatitis C virus infection and remains elevated in patients with chronic infection. Clin Immunol. 2009 Sep; 132(3):401-11. PMID: 19473882; PMCID: PMC2720442.
    58. Kuntzen T, Timm J, Berical A, Lennon N, Berlin AM, Young SK, Lee B, Heckerman D, Carlson J, Reyor LL, Kleyman M, McMahon CM, Birch C, Schulze Zur Wiesch J, Ledlie T, Koehrsen M, Kodira C, Roberts AD, Lauer GM, Rosen HR, Bihl F, Cerny A, Spengler U, Liu Z, Kim AY, Xing Y, Schneidewind A, Madey MA, Fleckenstein JF, Park VM, Galagan JE, Nusbaum C, Walker BD, Lake-Bakaar GV, Daar ES, Jacobson IM, Gomperts ED, Edlin BR, Donfield SM, Chung RT, Talal AH, Marion T, Birren BW, Henn MR, Allen TM. Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naïve patients. Hepatology. 2008 Dec; 48(6):1769-78. PMID: 19026009; PMCID: PMC2645896.
    59. Pandey JP, Namboodiri AM, Luo Y, Wu Y, Elston RC, Thomas DL, Rosen HR, Goedert JJ. Genetic markers of IgG influence the outcome of infection with hepatitis C virus. J Infect Dis. 2008 Nov 01; 198(9):1334-6. PMID: 18855559.
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    60. Yee LJ, Im K, Wahed AS, Bugawan T, Li J, Rhodes SL, Erlich H, Rosen HR, Liang TJ, Yang H. Polymorphism in the human major histocompatibility complex and early viral decline during treatment of chronic hepatitis C. Antimicrob Agents Chemother. 2009 Feb; 53(2):615-21. PMID: 18852273; PMCID: PMC2630649.
    61. Burton JR, Klarquist J, Im K, Smyk-Pearson S, Golden-Mason L, Castelblanco N, Terrault N, Rosen HR. Prospective analysis of effector and regulatory CD4+ T cells in chronic HCV patients undergoing combination antiviral therapy. J Hepatol. 2008 Sep; 49(3):329-38. PMID: 18644644.
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    62. Su X, Yee LJ, Im K, Rhodes SL, Tang Y, Tong X, Howell C, Ramcharran D, Rosen HR, Taylor MW, Liang TJ, Yang H. Association of single nucleotide polymorphisms in interferon signaling pathway genes and interferon-stimulated genes with the response to interferon therapy for chronic hepatitis C. J Hepatol. 2008 Aug; 49(2):184-91. PMID: 18571276; PMCID: PMC2609954.
    63. Rosen HR. Transplantation immunology: what the clinician needs to know for immunotherapy. Gastroenterology. 2008 May; 134(6):1789-801. PMID: 18471555.
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    64. Golden-Mason L, Klarquist J, Wahed AS, Rosen HR. Cutting edge: programmed death-1 expression is increased on immunocytes in chronic hepatitis C virus and predicts failure of response to antiviral therapy: race-dependent differences. J Immunol. 2008 Mar 15; 180(6):3637-41. PMID: 18322167.
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    65. Rosen HR, Doherty DG, Madrigal-Estebas L, O'Farrelly C, Golden-Mason L. Pretransplantation CD56(+) innate lymphocyte populations associated with severity of hepatitis C virus recurrence. Liver Transpl. 2008 Jan; 14(1):31-40. PMID: 18161829.
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    66. Smyk-Pearson S, Golden-Mason L, Klarquist J, Burton JR, Tester IA, Wang CC, Culbertson N, Vandenbark AA, Rosen HR. Functional suppression by FoxP3+CD4+CD25(high) regulatory T cells during acute hepatitis C virus infection. J Infect Dis. 2008 Jan 01; 197(1):46-57. PMID: 18171284.
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    67. Smyk-Pearson S, Tester IA, Klarquist J, Palmer BE, Pawlotsky JM, Golden-Mason L, Rosen HR. Spontaneous recovery in acute human hepatitis C virus infection: functional T-cell thresholds and relative importance of CD4 help. J Virol. 2008 Feb; 82(4):1827-37. PMID: 18045940; PMCID: PMC2258714.
    68. Mengshol JA, Golden-Mason L, Rosen HR. Mechanisms of Disease: HCV-induced liver injury. Nat Clin Pract Gastroenterol Hepatol. 2007 Nov; 4(11):622-34. PMID: 17978819.
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    69. Wang CC, Krantz E, Klarquist J, Krows M, McBride L, Scott EP, Shaw-Stiffel T, Weston SJ, Thiede H, Wald A, Rosen HR. Acute hepatitis C in a contemporary US cohort: modes of acquisition and factors influencing viral clearance. J Infect Dis. 2007 Nov 15; 196(10):1474-82. PMID: 18008226.
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    70. Rosen HR, Weston SJ, Im K, Yang H, Burton JR, Erlich H, Klarquist J, Belle SH. Selective decrease in hepatitis C virus-specific immunity among African Americans and outcome of antiviral therapy. Hepatology. 2007 Aug; 46(2):350-8. PMID: 17659573.
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    71. Golden-Mason L, Palmer B, Klarquist J, Mengshol JA, Castelblanco N, Rosen HR. Upregulation of PD-1 expression on circulating and intrahepatic hepatitis C virus-specific CD8+ T cells associated with reversible immune dysfunction. J Virol. 2007 Sep; 81(17):9249-58. PMID: 17567698; PMCID: PMC1951397.
    72. Golden-Mason L, Castelblanco N, O'Farrelly C, Rosen HR. Phenotypic and functional changes of cytotoxic CD56pos natural T cells determine outcome of acute hepatitis C virus infection. J Virol. 2007 Sep; 81(17):9292-8. PMID: 17553896; PMCID: PMC1951454.
    73. Wertheimer AM, Polyak SJ, Leistikow R, Rosen HR. Engulfment of apoptotic cells expressing HCV proteins leads to differential chemokine expression and STAT signaling in human dendritic cells. Hepatology. 2007 Jun; 45(6):1422-32. PMID: 17538964.
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    74. Zaman A, Rosen HR, Ingram K, Corless CL, Oh E, Smith K. Assessment of FIBROSpect II to detect hepatic fibrosis in chronic hepatitis C patients. Am J Med. 2007 Mar; 120(3):280.e9-14. PMID: 17349453.
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    75. Huang Y, Yang H, Borg BB, Su X, Rhodes SL, Yang K, Tong X, Tang G, Howell CD, Rosen HR, Thio CL, Thomas DL, Alter HJ, Sapp RK, Liang TJ. A functional SNP of interferon-gamma gene is important for interferon-alpha-induced and spontaneous recovery from hepatitis C virus infection. Proc Natl Acad Sci U S A. 2007 Jan 16; 104(3):985-90. PMID: 17215375; PMCID: PMC1783426.
    76. Golden-Mason L, Burton JR, Castelblanco N, Klarquist J, Benlloch S, Wang C, Rosen HR. Loss of IL-7 receptor alpha-chain (CD127) expression in acute HCV infection associated with viral persistence. Hepatology. 2006 Nov; 44(5):1098-109. PMID: 17058243.
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    77. Burton JR, Rosen HR. Acute rejection in HCV-infected liver transplant recipients: The great conundrum. Liver Transpl. 2006 Nov; 12(11 Suppl 2):S38-47. PMID: 17051562.
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    78. Smyk-Pearson S, Tester IA, Lezotte D, Sasaki AW, Lewinsohn DM, Rosen HR. Differential antigenic hierarchy associated with spontaneous recovery from hepatitis C virus infection: implications for vaccine design. J Infect Dis. 2006 Aug 15; 194(4):454-63. PMID: 16845628.
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    79. Burton JR, Rosen HR. Diagnosis and management of allograft failure. Clin Liver Dis. 2006 May; 10(2):407-35, x. PMID: 16971269.
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    80. Callender GG, Rosen HR, Roszkowski JJ, Lyons GE, Li M, Moore T, Brasic N, McKee MD, Nishimura MI. Identification of a hepatitis C virus-reactive T cell receptor that does not require CD8 for target cell recognition. Hepatology. 2006 May; 43(5):973-81. PMID: 16628627.
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    81. Golden-Mason L, Rosen HR. Natural killer cells: primary target for hepatitis C virus immune evasion strategies? Liver Transpl. 2006 Mar; 12(3):363-72. PMID: 16498647.
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    82. Burton JR, Rosen HR. Liver retransplantation for hepatitis C virus recurrence: a survey of liver transplant programs in the United States. Clin Gastroenterol Hepatol. 2005 Jul; 3(7):700-4. PMID: 16206504.
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    83. Tester I, Smyk-Pearson S, Wang P, Wertheimer A, Yao E, Lewinsohn DM, Tavis JE, Rosen HR. Immune evasion versus recovery after acute hepatitis C virus infection from a shared source. J Exp Med. 2005 Jun 06; 201(11):1725-31. PMID: 15939788; PMCID: PMC2213272.
    84. Weston SJ, Leistikow RL, Reddy KR, Torres M, Wertheimer AM, Lewinsohn DM, Chou S, Davey MP, Corless C, O'Farrelly C, Nelson DR, Rosen HR. Reconstitution of hepatitis C virus-specific T-cellmediated immunity after liver transplantation. Hepatology. 2005 Jan; 41(1):72-81. PMID: 15619226.
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    85. Cabrera R, Tu Z, Xu Y, Firpi RJ, Rosen HR, Liu C, Nelson DR. An immunomodulatory role for CD4(+)CD25(+) regulatory T lymphocytes in hepatitis C virus infection. Hepatology. 2004 Nov; 40(5):1062-71. PMID: 15486925.
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    86. Wertheimer AM, Bakke A, Rosen HR. Direct enumeration and functional assessment of circulating dendritic cells in patients with liver disease. Hepatology. 2004 Aug; 40(2):335-45. PMID: 15368438.
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    87. Austin GL, Sasaki AW, Zaman A, Rabkin JM, Olyaei A, Ruimy R, Orloff SL, Ham J, Rosen HR. Comparative analysis of outcome following liver transplantation in US veterans. Am J Transplant. 2004 May; 4(5):788-95. PMID: 15084176.
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    88. Zaman A, Hapke RJ, Flora K, Rosen HR, Benner KG. Changing compliance to the American College of Gastroenterology guidelines for the management of variceal hemorrhage: a regional survey. Am J Gastroenterol. 2004 Apr; 99(4):645-9. PMID: 15089896.
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    89. Chan SE, Schwartz JM, Rosen HR. Treatment of hepatitis C in solid organ transplantation. Drugs. 2004; 64(5):489-98. PMID: 14977386.
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    90. Simon BE, Cornell KA, Clark TR, Chou S, Rosen HR, Barry RA. DNA vaccination protects mice against challenge with Listeria monocytogenes expressing the hepatitis C virus NS3 protein. Infect Immun. 2003 Nov; 71(11):6372-80. PMID: 14573658; PMCID: PMC219586.
    91. Rosen HR. Hepatitis C pathogenesis: mechanisms of viral clearance and liver injury. Liver Transpl. 2003 Nov; 9(11):S35-43. PMID: 14586893.
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    92. Gopal DV, Corless CL, Rabkin JM, Olyaei AJ, Rosen HR. Graft failure from severe recurrent primary sclerosing cholangitis following orthotopic liver transplantation. J Clin Gastroenterol. 2003 Oct; 37(4):344-7. PMID: 14506394.
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    93. Chan SE, Rosen HR. Outcome and management of hepatitis C in liver transplant recipients. Clin Infect Dis. 2003 Sep 15; 37(6):807-12. PMID: 12955642.
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    94. Rosen HR, Prieto M, Casanovas-Taltavull T, Cuervas-Mons V, Guckelberger O, Muiesan P, Strong RW, Bechstein WO, O'grady J, Zaman A, Chan B, Berenguer J, Williams R, Heaton N, Neuhaus P. Validation and refinement of survival models for liver retransplantation. Hepatology. 2003 Aug; 38(2):460-9. PMID: 12883491.
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    95. Gopal DV, Rosen HR. Duration of antiviral therapy for cholestatic HCV recurrence may need to be indefinite. Liver Transpl. 2003 Apr; 9(4):348-53. PMID: 12682884.
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    96. Wertheimer AM, Miner C, Lewinsohn DM, Sasaki AW, Kaufman E, Rosen HR. Novel CD4+ and CD8+ T-cell determinants within the NS3 protein in subjects with spontaneously resolved HCV infection. Hepatology. 2003 Mar; 37(3):577-89. PMID: 12601356.
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    97. Rosen HR, Marousek G, Chou S. A longitudinal analysis of T-cell epitope-coding regions of hepatitis C virus after liver transplantation. Transplantation. 2002 Jul 27; 74(2):209-16. PMID: 12151733.
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    98. Rosen HR, Schwartz JM. Hepatitis C quasispecies and severity of recurrence: cause, consequence, or coincidence? Liver Transpl. 2002 Jul; 8(7):646-8. PMID: 12089722.
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    99. Rosen HR, Ribeiro RR, Weinberger L, Wolf S, Chung M, Gretch DR, Perelson AS. Early hepatitis C viral kinetics correlate with long-term outcome in patients receiving high dose induction followed by combination interferon and ribavirin therapy. J Hepatol. 2002 Jul; 37(1):124-30. PMID: 12076871.
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    100. Murphy MD, Rosen HR, Marousek GI, Chou S. Analysis of sequence configurations of the ISDR, PKR-binding domain, and V3 region as predictors of response to induction interferon-alpha and ribavirin therapy in chronic hepatitis C infection. Dig Dis Sci. 2002 Jun; 47(6):1195-205. PMID: 12064791.
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    101. Rosen HR, Miner C, Sasaki AW, Lewinsohn DM, Conrad AJ, Bakke A, Bouwer HG, Hinrichs DJ. Frequencies of HCV-specific effector CD4+ T cells by flow cytometry: correlation with clinical disease stages. Hepatology. 2002 Jan; 35(1):190-8. PMID: 11786976.
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