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Howard Silberman, MD

Title(s)Professor of Surgery
Phone+1 323 865 3000
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    Dr. Howard Silberman, Professor of Surgery at the Keck School of Medicine of the University of Southern California, was awarded the M.D. degree by the Jefferson Medical College in Philadelphia and received his postgraduate training in surgery at the Hospital of the University of Pennsylvania. He is a Diplomate of the American Board of Surgery, a Fellow of the American College of Surgeons, and has been elected to membership in various professional organizations, including the Society of University Surgeons, the American Society of Clinical Oncology, the Society of Surgical Oncology, the American Society of Breast Surgeons, the Society for Surgery of the Alimentary Tract, and the American Society for Parenteral and Enteral Nutrition. As a member of the full-time Attending Staff of the USC/Norris Cancer Hospital, Dr. Silberman specializes in the management of breast cancer as well as tumors of the gastrointestional tract and malignant melanoma. He serves as the Associate Director of the Harold E. and Henrietta C. Lee Breast Center at the USC/Norris Comprehensive Cancer Center and Hospital. He also attends in the Division of Tumor and Endocrine Surgery at the Los Angeles County-USC Medical Center. Dr. Silberman’s clinical interests are reflected in his book, Principles and Practice of Surgical Oncology: Multidisciplinary Approach to Difficult Problems. This work considers the management of patients with complicated, advanced, or unusual tumors of the stomach, pancreas, small intestine, colon, rectum, and soft tissues including breast cancer, melanoma, and sarcoma. The text emphasizes a combined multidisciplinary approach (drug therapy, radiotherapy, and surgery) to the treatment of cancer. Dr. Silberman also has a long standing interest in surgical nutrition and is the author of text Parenteral and Enteral Nutrition.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Silberman H, Sheth PA, Parisky YR, Hovanessian-Larsen LJ, Sheth S, Tripathy D. Modified Bi-Rads Scoring of Breast Imaging Findings Improves Clinical Judgment. Breast J. 2015 Nov-Dec; 21(6):642-50. PMID: 26411901.
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    2. Leilabadi SN, Chen A, Tsai S, Soundararajan V, Silberman H, Wong AK. Update and Review on the Surgical Management of Primary Cutaneous Melanoma. Healthcare (Basel). 2014 Jun 10; 2(2):234-49. PMID: 27429273; PMCID: PMC4934469.
    3. Chan JL, Silberman H. Image of the month-quiz case. Diagnosis: primary adenocarcinoma. Arch Surg. 2012 Sep; 147(9):887-8. PMID: 22987191.
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    4. Chan JL, Silberman H. Image of the month-quiz case. Arch Surg. 2012 Sep 01; 147(9). PMID: 24901811.
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    5. Macdonald HR, Silverstein MJ, Lee LA, Ye W, Sanghavi P, Holmes DR, Silberman H, Lagios M. Margin width as the sole determinant of local recurrence after breast conservation in patients with ductal carcinoma in situ of the breast. Am J Surg. 2006 Oct; 192(4):420-2. PMID: 16978941.
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    6. Lee LA, Silverstein MJ, Chung CT, Macdonald H, Sanghavi P, Epstein M, Holmes DR, Silberman H, Ye W, Lagios MD. Breast cancer-specific mortality after invasive local recurrence in patients with ductal carcinoma-in-situ of the breast. Am J Surg. 2006 Oct; 192(4):416-9. PMID: 16978940.
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    7. MacDonald HR, Silverstein MJ, Mabry H, Moorthy B, Ye W, Epstein MS, Holmes D, Silberman H, Lagios M. Local control in ductal carcinoma in situ treated by excision alone: incremental benefit of larger margins. Am J Surg. 2005 Oct; 190(4):521-5. PMID: 16164913.
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    8. Silberman H. Perioperative adjunctive treatment in the management of operable gastric cancer. J Surg Oncol. 2005 Jun 01; 90(3):174-86; discussion 186-7. PMID: 15895444.
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    9. Romero L, Klein L, Ye W, Holmes D, Soni R, Silberman H, Lagios MD, Silverstein MJ. Outcome after invasive recurrence in patients with ductal carcinoma in situ of the breast. Am J Surg. 2004 Oct; 188(4):371-6. PMID: 15474428.
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    10. Streeter OE, Vicini FA, Keisch M, Astrahan MA, Jozsef G, Silverstein M, Silberman H, Cohen D, Skinner KA. MammoSite radiation therapy system. Breast. 2003 Dec; 12(6):491-6. PMID: 14659126.
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    11. Nakamura S, Woo C, Silberman H, Streeter OE, Lewinsky BS, Silverstein MJ. Breast-conserving therapy for ductal carcinoma in situ: a 20-year experience with excision plus radiation therapy. Am J Surg. 2002 Nov; 184(5):403-9. PMID: 12433602.
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    12. Woo CS, Silberman H, Nakamura SK, Ye W, Sposto R, Colburn W, Waisman JR, Silverstein MJ. Lymph node status combined with lymphovascular invasion creates a more powerful tool for predicting outcome in patients with invasive breast cancer. Am J Surg. 2002 Oct; 184(4):337-40. PMID: 12383896.
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    13. Skinner KA, Silberman H, Sposto R, Silverstein MJ. Palpable breast cancers are inherently different from nonpalpable breast cancers. Ann Surg Oncol. 2001 Oct; 8(9):705-10. PMID: 11597010.
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    14. Garcia AA, Muggia FM, Spears CP, Jeffers S, Silberman H, Pujari M, Koda RT. Phase I and pharmacologic study of i.v. hydroxyurea infusion given with i.p. 5-fluoro-2'-deoxyuridine and leucovorin. Anticancer Drugs. 2001 Jul; 12(6):505-11. PMID: 11459996.
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    15. Skinner KA, Silberman H, Dougherty W, Gamagami P, Waisman J, Sposto R, Silverstein MJ. Breast cancer after augmentation mammoplasty. Ann Surg Oncol. 2001 Mar; 8(2):138-44. PMID: 11258778.
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    16. Skinner KA, Silberman H, Florentine B, Lomis TJ, Corso F, Spicer D, Formenti SC. Preoperative paclitaxel and radiotherapy for locally advanced breast cancer: surgical aspects. Ann Surg Oncol. 2000 Mar; 7(2):145-9. PMID: 10761794.
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    17. Metzger R, Leichman CG, Danenberg KD, Danenberg PV, Lenz HJ, Hayashi K, Groshen S, Salonga D, Cohen H, Laine L, Crookes P, Silberman H, Baranda J, Konda B, Leichman L. ERCC1 mRNA levels complement thymidylate synthase mRNA levels in predicting response and survival for gastric cancer patients receiving combination cisplatin and fluorouracil chemotherapy. J Clin Oncol. 1998 Jan; 16(1):309-16. PMID: 9440758.
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    18. Formenti SC, Dunnington G, Uzieli B, Lenz H, Keren-Rosenberg S, Silberman H, Spicer D, Denk M, Leichman G, Groshen S, Watkins K, Muggia F, Florentine B, Press M, Danenberg K, Danenberg P. Original p53 status predicts for pathological response in locally advanced breast cancer patients treated preoperatively with continuous infusion 5-fluorouracil and radiation therapy. Int J Radiat Oncol Biol Phys. 1997 Dec 01; 39(5):1059-68. PMID: 9392545.
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    19. Skinner KA, Dunnington G, Silberman H, Florentine B, Spicer D, Formenti SC. Preoperative 5-fluorouracil and radiation therapy for locally advanced breast cancer. Am J Surg. 1997 Dec; 174(6):705-7; discussion 707-8. PMID: 9409601.
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    20. Crookes P, Leichman CG, Leichman L, Tan M, Laine L, Stain S, Baranda J, Casagrande Y, Groshen S, Silberman H. Systemic chemotherapy for gastric carcinoma followed by postoperative intraperitoneal therapy: a final report. Cancer. 1997 May 01; 79(9):1767-75. PMID: 9128994.
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    21. Lenz HJ, Leichman CG, Danenberg KD, Danenberg PV, Groshen S, Cohen H, Laine L, Crookes P, Silberman H, Baranda J, Garcia Y, Li J, Leichman L. Thymidylate synthase mRNA level in adenocarcinoma of the stomach: a predictor for primary tumor response and overall survival. J Clin Oncol. 1996 Jan; 14(1):176-82. PMID: 8558194.
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    22. Tang E, Davis J, Silberman H. Bowel obstruction in cancer patients. Arch Surg. 1995 Aug; 130(8):832-6; discussion 836-7. PMID: 7632142.
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    23. Leichman L, Lenz HJ, Leichman CG, Groshen S, Danenberg K, Baranda J, Spears CP, Boswell W, Silberman H, Ortega A. Quantitation of intratumoral thymidylate synthase expression predicts for resistance to protracted infusion of 5-fluorouracil and weekly leucovorin in disseminated colorectal cancers: preliminary report from an ongoing trial. Eur J Cancer. 1995 Jul-Aug; 31A(7-8):1306-10. PMID: 7577041.
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    24. Keung YK, Watkins K, Chen SC, Groshen S, Silberman H, Douer D. Comparative study of infectious complications of different types of chronic central venous access devices. Cancer. 1994 Jun 01; 73(11):2832-7. PMID: 7864923.
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    25. Treiman GS, Silberman H. Chronic venous access in patients with cancer. Selective use of the saphenous vein. Cancer. 1993 Aug 01; 72(3):760-5. PMID: 8334628.
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    26. Leichman L, Silberman H, Leichman CG, Spears CP, Ray M, Muggia FM, Kiyabu M, Radin R, Laine L, Stain S. Preoperative systemic chemotherapy followed by adjuvant postoperative intraperitoneal therapy for gastric cancer: a University of Southern California pilot program. J Clin Oncol. 1992 Dec; 10(12):1933-42. PMID: 1453207.
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    27. Silberman H, Berne TV, Escandon R. Prospective evaluation of a double-lumen subclavian dialysis catheter for acute vascular access. Am Surg. 1992 Aug; 58(8):443-5. PMID: 1642376.
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    28. Kern JW, Lee KJ, Martinoff JT, Silberman H. The in vivo availability of gentamicin when admixed with total nutrient solutions: a comparative study. JPEN J Parenter Enteral Nutr. 1990 Sep-Oct; 14(5):523-6. PMID: 2122026.
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    29. Tyrell J, Silberman H, Chandrasoma P, Niland J, Shull J. Absorbable versus permanent mesh in abdominal operations. Surg Gynecol Obstet. 1989 Mar; 168(3):227-32. PMID: 2537535.
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    30. Ardalan B, Singh G, Silberman H. A randomized phase I and II study of short-term infusion of high-dose fluorouracil with or without N-(phosphonacetyl)-L-aspartic acid in patients with advanced pancreatic and colorectal cancers. J Clin Oncol. 1988 Jun; 6(6):1053-8. PMID: 3373260.
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    31. Silberman H, Eisenberg D, Ryan J, Shofler R, Niland J, Kaptein E, Nicoloff J, Spencer C. The relation of thyroid indices in the critically ill patient to prognosis and nutritional factors. Surg Gynecol Obstet. 1988 Mar; 166(3):223-8. PMID: 3344451.
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    32. Spicer DV, Ardalan B, Daniels JR, Silberman H, Johnson K. Reevaluation of the maximum tolerated dose of continuous venous infusion of 5-fluorouracil with pharmacokinetics. Cancer Res. 1988 Jan 15; 48(2):459-61. PMID: 3335014.
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    33. Cohen HJ, Bartolucci AA, Forman WB, Silberman HR. Consolidation and maintenance therapy in multiple myeloma: randomized comparison of a new approach to therapy after initial response to treatment. J Clin Oncol. 1986 Jun; 4(6):888-99. PMID: 3519879.
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    34. Cohen HJ, Silberman HR, Tornyos K, Bartolucci AA. Comparison of two long-term chemotherapy regimens, with or without agents to modify skeletal repair, in multiple myeloma. Blood. 1984 Mar; 63(3):639-48. PMID: 6421344.
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    35. Cohen HJ, Silberman HR, Forman W, Bartolucci A, Liu C. Effects of age on responses to treatment and survival of patients with multiple myeloma. J Am Geriatr Soc. 1983 May; 31(5):272-7. PMID: 6841855.
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    36. Ghanta VK, Cohen HJ, Silberman HR, Durant JR, Hiramoto RN. Assessment of myeloma maintenance regimen of prednisone. Adriamycin, imuran, and vincristine in a murine plasmacytoma model. Cancer Clin Trials. 1981; 4(2):135-41. PMID: 7249251.
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    37. Cohen HJ, Silberman HR, Larsen WE, Johnson L, Bartolucci AA, Durant JR. Combination chemotherapy with intermittent 1-3-bis(2-chloroethyl)1-nitrosourea (BCNU), cyclophosphamide, and prednisone for multiple myeloma. Blood. 1979 Oct; 54(4):824-36. PMID: 476303.
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