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    Hiroyuki Shimada, MD, PhD

    TitleProfessor of Clinical Pathology
    SchoolKeck School of Medicine of USC
    DepartmentPediatrics
    AddressCHL Mail Stop 43
    Off Campus
    Los Angeles California 90089
    Phone+1 323 361 5813
    vCardDownload vCard

      Collapse Biography 
      Collapse Awards and Honors
      Society for Pediatric Pathology1989Lotte Strauss Prize
      University of Chicago2005Eleanor Humphreys Visiting Professorship

      Collapse ORNG Applications 
      Collapse Websites

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Tsutsumimoto K, Doi T, Makizako H, Hotta R, Nakakubo S, Makino K, Suzuki T, Shimada H. Association of Social Frailty With Both Cognitive and Physical Deficits Among Older People. J Am Med Dir Assoc. 2017 Apr 11. PMID: 28411094.
        View in: PubMed
      2. Kasai T, Kondo M, Ishii R, Tanaka A, Ataka S, Shimada H, Tomiyama T, Mori H, Taylor M, Allsop D, Nakagawa M, Mizuno T, Tokuda T. Aß levels in the jugular vein and high molecular weight Aß oligomer levels in CSF can be used as biomarkers to indicate the anti-amyloid effect of IVIg for Alzheimer's disease. PLoS One. 2017; 12(4):e0174630. PMID: 28394917.
        View in: PubMed
      3. Doi T, Verghese J, Makizako H, Tsutsumimoto K, Hotta R, Nakakubo S, Suzuki T, Shimada H. Effects of Cognitive Leisure Activity on Cognition in Mild Cognitive Impairment: Results of a Randomized Controlled Trial. J Am Med Dir Assoc. 2017 Apr 07. PMID: 28396179.
        View in: PubMed
      4. Mori R, Nakashizuka H, Machida Y, Shimada H, Yuzawa M. Postoperative roll cake-like macular fold after retinal detachment surgery. Int Ophthalmol. 2017 Apr 03. PMID: 28374275.
        View in: PubMed
      5. Yamada Y, Shima H, Shibata H, Ishii T, Hasegawa T, Shimada H. Severe hypertriglyceridemia during treatment of acute lymphoblastic leukemia associated with type III hyperlipoproteinemia. Pediatr Blood Cancer. 2017 Apr 01. PMID: 28371240.
        View in: PubMed
      6. Umegaki H, Makino T, Uemura K, Shimada H, Hayashi T, Cheng XW, Kuzuya M. The Associations among Insulin Resistance, Hyperglycemia, Physical Performance, Diabetes Mellitus, and Cognitive Function in Relatively Healthy Older Adults with Subtle Cognitive Dysfunction. Front Aging Neurosci. 2017; 9:72. PMID: 28386227.
        View in: PubMed
      7. Makizako H, Shimada H, Doi T, Tsutsumimoto K, Nakakubo S, Hotta R, Suzuki T. Predictive Cutoff Values of the Five-Times Sit-to-Stand Test and the Timed "Up & Go" Test for Disability Incidence in Older People Dwelling in the Community. Phys Ther. 2017 Mar 22. PMID: 28371914.
        View in: PubMed
      8. Shimada H, Arai S, Nakashizuka H, Hattori T, Yuzawa M. Reduced anterior chamber contamination by frequent surface irrigation with diluted iodine solutions during cataract surgery. Acta Ophthalmol. 2017 Mar 08. PMID: 28271619.
        View in: PubMed
      9. Shima H, Kiyokawa N, Miharu M, Tanizawa A, Kurosawa H, Watanabe A, Ito M, Tono C, Yuza Y, Muramatsu H, Hotta N, Okada M, Hamamoto K, Kajiwara R, Saito AM, Horibe K, Mizutani S, Adachi S, Ishii E, Shimada H. Flow cytometric analysis as an additional predictive tool of treatment response in children with chronic-phase chronic myeloid leukemia treated with imatinib. Pediatr Blood Cancer. 2017 Feb 24. PMID: 28233439.
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      10. Tanaka K, Miyake Y, Fukushima W, Kiyohara C, Sasaki S, Tsuboi Y, Oeda T, Shimada H, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M, Nakamura Y. Vitamin D receptor gene polymorphisms, smoking, and risk of sporadic Parkinson's disease in Japan. Neurosci Lett. 2017 Mar 16; 643:97-102. PMID: 28216333.
        View in: PubMed
      11. Nakakubo S, Makizako H, Doi T, Tsutsumimoto K, Lee S, Lee S, Hotta R, Bae S, Suzuki T, Shimada H. Impact of poor sleep quality and physical inactivity on cognitive function in community-dwelling older adults. Geriatr Gerontol Int. 2017 Feb 11. PMID: 28188962.
        View in: PubMed
      12. Miki T, Shimada H, Kim JS, Yamamoto Y, Sugino M, Kowa H, Heurling K, Zanette M, Sherwin PF, Senda M. Brain uptake and safety of Flutemetamol F 18 injection in Japanese subjects with probable Alzheimer's disease, subjects with amnestic mild cognitive impairment and healthy volunteers. Ann Nucl Med. 2017 Feb 08. PMID: 28181118.
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      13. Kodama Y, Manabe A, Kawasaki H, Kato I, Kato K, Sato A, Matsumoto K, Kato M, Hiramatsu H, Sano H, Kaneko T, Oda M, Saito AM, Adachi S, Horibe K, Mizutani S, Ishii E, Shimada H. Salvage therapy for children with relapsed or refractory Philadelphia chromosome-positive acute lymphoblastic leukemia. Pediatr Blood Cancer. 2017 Jan 13. PMID: 28084041.
        View in: PubMed
      14. Tsutsumimoto K, Makizako H, Doi T, Hotta R, Nakakubo S, Makino K, Shimada H, Suzuki T. Subjective Memory Complaints are Associated with Incident Dementia in Cognitively Intact Older People, but Not in Those with Cognitive Impairment: A 24-Month Prospective Cohort Study. Am J Geriatr Psychiatry. 2017 Jan 04. PMID: 28216174.
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      15. Tsutsumimoto K, Doi T, Makizako H, Hotta R, Nakakubo S, Makino K, Suzuki T, Shimada H. The association between anorexia of aging and physical frailty: Results from the national center for geriatrics and gerontology's study of geriatric syndromes. Maturitas. 2017 Mar; 97:32-37. PMID: 28159059.
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      16. Burchill SA, Beiske K, Shimada H, Ambros PF, Seeger R, Tytgat GA, Brock PR, Haber M, Park JR, Berthold F. Recommendations for the standardization of bone marrow disease assessment and reporting in children with neuroblastoma; on behalf of the International Neuroblastoma Response Criteria Bone Marrow Working Group. Cancer. 2016 Dec 16. PMID: 27984660.
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      17. Shimada H, Nakashizuka H, Grzybowski A. Prevention and treatment of postoperative endophthalmitis using povidone-iodine. Curr Pharm Des. 2016 Dec 04. PMID: 27917719.
        View in: PubMed
      18. Erdreich-Epstein A, Singh AR, Joshi S, Vega FM, Guo P, Xu J, Groshen S, Ye W, Millard M, Campan M, Morales G, Garlich JR, Laird PW, Seeger RC, Shimada H, Durden DL. Association of high microvessel avß3 and low PTEN with poor outcome in stage 3 neuroblastoma: rationale for using first in class dual PI3K/BRD4 inhibitor, SF1126. Oncotarget. 2016 Nov 16. PMID: 27907905.
        View in: PubMed
      19. Kojima G, Iliffe S, Taniguchi Y, Shimada H, Rakugi H, Walters K. Prevalence of frailty in Japan: A systematic review and meta-analysis. J Epidemiol. 2016 Nov 15. PMID: 28142044.
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      20. Coburn J, Harris J, Zakharov AD, Poirier J, Ikegaki N, Kajdacsy-Balla A, Pilichowska M, Lyubimov AV, Shimada H, Kaplan DL, Chiu B. Implantable chemotherapy-loaded silk protein materials for neuroblastoma treatment. Int J Cancer. 2016 Oct 22. PMID: 27770551.
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      21. Makizako H, Shimada H, Doi T, Tsutsumimoto K, Hotta R, Nakakubo S, Makino K, Suzuki T. Comorbid Mild Cognitive Impairment and Depressive Symptoms Predict Future Dementia in Community Older Adults: A 24-Month Follow-Up Longitudinal Study. J Alzheimers Dis. 2016 Oct 18; 54(4):1473-1482. PMID: 27589518.
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      22. Li L, Qi X, Sun W, Abdel-Azim H, Lou S, Zhu H, Prasadarao NV, Zhou A, Shimada H, Shudo K, Kim YM, Khazal S, He Q, Warburton D, Wu L. Am80-GCSF synergizes myeloid expansion and differentiation to generate functional neutrophils that reduce neutropenia-associated infection and mortality. EMBO Mol Med. 2016 Oct 13. PMID: 27737899.
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      23. Kadoya M, Hida A, Hashimoto Maeda M, Taira K, Ikenaga C, Uchio N, Kubota A, Kaida K, Miwa Y, Kurasawa K, Shimada H, Sonoo M, Chiba A, Shiio Y, Uesaka Y, Sakurai Y, Izumi T, Inoue M, Kwak S, Tsuji S, Shimizu J. Cancer association as a risk factor for anti-HMGCR antibody-positive myopathy. Neurol Neuroimmunol Neuroinflamm. 2016 Dec; 3(6):e290. PMID: 27761483.
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      24. Nakashizuka H, Shoji J, Shimada H, Yuzawa M. EXPERIMENTAL VISUALIZATION AND QUANTIFICATION OF VITREOUS CONTAMINATION FOLLOWING INTRAVITREAL INJECTIONS. Retina. 2016 Oct; 36(10):1882-7. PMID: 27046457.
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      25. Lee S, Lee S, Harada K, Bae S, Makizako H, Doi T, Tsutsumimoto K, Hotta R, Nakakubo S, Park H, Suzuki T, Shimada H. Relationship between chronic kidney disease with diabetes or hypertension and frailty in community-dwelling Japanese older adults. Geriatr Gerontol Int. 2016 Sep 27. PMID: 27670391.
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      26. Watanabe Y, Hirano H, Arai H, Morishita S, Ohara Y, Edahiro A, Murakami M, Shimada H, Kikutani T, Suzuki T. Relationship Between Frailty and Oral Function in Community-Dwelling Elderly Adults. J Am Geriatr Soc. 2017 Jan; 65(1):66-76. PMID: 27655106.
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      27. Harada K, Lee S, Lee S, Bae S, Harada K, Suzuki T, Shimada H. Objectively-measured outdoor time and physical and psychological function among older adults. Geriatr Gerontol Int. 2016 Sep 16. PMID: 27633728.
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      28. Shinojima A, Mori R, Nakashizuka H, Shimada H. Characteristics of Hyperautofluorescent Choroidal Vessels Using Fundus Camera Type Short-Wavelength Autofluorescence. Ophthalmologica. 2016; 236(3):175-180. PMID: 27614990.
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      29. Harada K, Park H, Lee S, Shimada H, Yoshida D, Anan Y, Suzuki T. Joint Association of Neighborhood Environment and Fear of Falling on Physical Activity Among Frail Older Adults. J Aging Phys Act. 2016 Sep 6; 1-28. PMID: 27620962.
        View in: PubMed
      30. Shimada H, Makizako H, Tsutsumimoto K, Hotta R, Nakakubo S, Doi T. Driving and Incidence of Functional Limitation in Older People: A Prospective Population-Based Study. Gerontology. 2016; 62(6):636-643. PMID: 27532637.
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      31. Chen NE, Maldonado NV, Khankaldyyan V, Shimada H, Song MM, Maurer BJ, Reynolds CP. Reactive Oxygen Species Mediates the Synergistic Activity of Fenretinide Combined with the Microtubule Inhibitor ABT-751 against Multidrug-Resistant Recurrent Neuroblastoma Xenografts. Mol Cancer Ther. 2016 Aug 16. PMID: 27530131.
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      32. Harada K, Lee S, Shimada H, Lee S, Bae S, Anan Y, Harada K, Suzuki T. Psychological predictors of participation in screening for cognitive impairment among community-dwelling older adults. Geriatr Gerontol Int. 2016 Jul 18. PMID: 27427234.
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      33. Morgenstern DA, London WB, Stephens D, Volchenboum SL, Simon T, Nakagawara A, Shimada H, Schleiermacher G, Matthay KK, Cohn SL, Pearson AD, Irwin MS. Prognostic significance of pattern and burden of metastatic disease in patients with stage 4 neuroblastoma: A study from the International Neuroblastoma Risk Group database. Eur J Cancer. 2016 Sep; 65:1-10. PMID: 27434878.
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      34. Shimada H, Makizako H, Doi T, Tsutsumimoto K, Lee S, Suzuki T. Cognitive Impairment and Disability in Older Japanese Adults. PLoS One. 2016; 11(7):e0158720. PMID: 27415430.
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      35. Doi T, Blumen HM, Verghese J, Shimada H, Makizako H, Tsutsumimoto K, Hotta R, Nakakubo S, Suzuki T. Gray matter volume and dual-task gait performance in mild cognitive impairment. Brain Imaging Behav. 2016 Jul 09. PMID: 27392792.
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      36. Nakakubo S, Doi T, Makizako H, Tsutsumimoto K, Hotta R, Ono R, Suzuki T, Shimada H. Sleep Duration and Excessive Daytime Sleepiness Are Associated With Incidence of Disability in Community-Dwelling Older Adults. J Am Med Dir Assoc. 2016 Aug 1; 17(8):768.e1-5. PMID: 27397602.
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      37. Shimada H, Makizako H, Doi T. [Exercise and Physical Activity for Dementia Prevention]. Brain Nerve. 2016 Jul; 68(7):799-808. PMID: 27395464.
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      38. Hida A, Yamashita T, Hosono Y, Inoue M, Kaida K, Kadoya M, Miwa Y, Yajima N, Maezawa R, Arai S, Kurasawa K, Ito K, Shimada H, Iwanami T, Sonoo M, Hatanaka Y, Murayama S, Uchibori A, Chiba A, Aizawa H, Momoo T, Nakae Y, Sakurai Y, Shiio Y, Hashida H, Yoshizawa T, Sakiyama Y, Oda A, Inoue K, Takeuchi S, Iwata NK, Date H, Masuda N, Mikata T, Motoyoshi Y, Uesaka Y, Maeda MH, Nakashima R, Tsuji S, Kwak S, Mimori T, Shimizu J. Anti-TIF1-? antibody and cancer-associated myositis: A clinicohistopathologic study. Neurology. 2016 Jul 19; 87(3):299-308. PMID: 27343066.
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      39. Lee S, Shimada H, Lee S, Makizako H, Doi T, Harada K, Bae S, Harada K, Hotta R, Tsutsumimoto K, Yoshida D, Nakakubo S, Anan Y, Park H, Suzuki T. Association between sedentary time and kidney function in community-dwelling elderly Japanese people. Geriatr Gerontol Int. 2016 Jun 14. PMID: 27295943.
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      40. Inoue M, Baba H, Yamamoto K, Shimada H, Yamakawa Y, Suzuki T, Miki T, Arai H. Serum Levels of Albumin-ß-Amyloid Complex in Patients with Depression. Am J Geriatr Psychiatry. 2016 Sep; 24(9):764-72. PMID: 27401050.
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      41. Jackson JR, Tran HC, Stein JE, Shimada H, Patel AM, Marachelian A, Kim ES. The clinical management and outcomes of cervical neuroblastic tumors. J Surg Res. 2016 Jul; 204(1):109-13. PMID: 27451875.
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      42. Villablanca JG, Volchenboum SL, Cho H, Kang MH, Cohn SL, Anderson CP, Marachelian A, Groshen S, Tsao-Wei D, Matthay KK, Maris JM, Hasenauer CE, Czarnecki S, Lai H, Goodarzian F, Shimada H, Reynolds CP. A Phase I New Approaches to Neuroblastoma Therapy Study of Buthionine Sulfoximine and Melphalan With Autologous Stem Cells for Recurrent/Refractory High-Risk Neuroblastoma. Pediatr Blood Cancer. 2016 Aug; 63(8):1349-56. PMID: 27092812.
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      43. Tsutsumimoto K, Makizako H, Doi T, Hotta R, Nakakubo S, Shimada H, Suzuki T. Prospective associations between sedentary behaviour and incident depressive symptoms in older people: a 15-month longitudinal cohort study. Int J Geriatr Psychiatry. 2017 Feb; 32(2):193-200. PMID: 26988851.
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      44. Kitagawa Y, Shimada H, Mori R, Tanaka K, Yuzawa M. Intravitreal Tissue Plasminogen Activator, Ranibizumab, and Gas Injection for Submacular Hemorrhage in Polypoidal Choroidal Vasculopathy. Ophthalmology. 2016 Jun; 123(6):1278-86. PMID: 26949121.
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      45. Shimada H. [Significance and progress of DIAN/A4/API]. Nihon Rinsho. 2016 Mar; 74(3):417-22. PMID: 27025079.
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      46. DuBois SG, Marachelian A, Fox E, Kudgus RA, Reid JM, Groshen S, Malvar J, Bagatell R, Wagner L, Maris JM, Hawkins R, Courtier J, Lai H, Goodarzian F, Shimada H, Czarnecki S, Tsao-Wei D, Matthay KK, Mosse YP. Phase I Study of the Aurora A Kinase Inhibitor Alisertib in Combination With Irinotecan and Temozolomide for Patients With Relapsed or Refractory Neuroblastoma: A NANT (New Approaches to Neuroblastoma Therapy) Trial. J Clin Oncol. 2016 Apr 20; 34(12):1368-75. PMID: 26884555.
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      47. Miyake Y, Tanaka K, Fukushima W, Kiyohara C, Sasaki S, Tsuboi Y, Oeda T, Shimada H, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M, Nakamura Y. PARK16 polymorphisms, interaction with smoking, and sporadic Parkinson's disease in Japan. J Neurol Sci. 2016 Mar 15; 362:47-52. PMID: 26944116.
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      48. Tsutsumimoto K, Doi T, Shimada H, Makizako H, Suzuki T. Effects of group exercise programmes on quality of life in older adults with mild cognitive impairment: preliminary results from a randomized controlled trial. Psychogeriatrics. 2016 Sep; 16(5):327-8. PMID: 26757136.
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      49. Hayashi Y, Hato S, Imada T, Kobayashi O, Abe T, Oonuma T, Shimada H. The effects of the employment of physical therapists and occupational therapists on the gait function of adult day service users after 1 year. Nihon Ronen Igakkai Zasshi. 2016; 53(4):412-418. PMID: 27885229.
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      50. Furukawa K, Tomita N, Uematsu D, Okahara K, Shimada H, Ikeda M, Matsui T, Kozaki K, Fujii M, Ogawa T, Umegaki H, Urakami K, Nomura H, Kobayashi N, Nakanishi A, Washimi Y, Yonezawa H, Takahashi S, Kubota M, Wakutani Y, Ito D, Sasaki T, Matsubara E, Une K, Ishiki A, Yahagi Y, Shoji M, Sato H, Terayama Y, Kuzuya M, Araki N, Kodama M, Yamaguchi T, Arai H. Randomized double-blind placebo-controlled multicenter trial of Yokukansan for neuropsychiatric symptoms in Alzheimer's disease. Geriatr Gerontol Int. 2017 Feb; 17(2):211-218. PMID: 26711658.
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      51. Uemura K, Shimada H, Makizako H, Doi T, Tsutsumimoto K, Lee S, Umegaki H, Kuzuya M, Suzuki T. Effects of Mild Cognitive Impairment on the Development of Fear of Falling in Older Adults: A Prospective Cohort Study. J Am Med Dir Assoc. 2015 Dec 1; 16(12):1104.e9-1104.e13. PMID: 26593307.
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      52. Warren M, Shimada H. Importance of Phox2B Immunohistochemical Stain for Detecting Metastatic Neuroblastoma Cells in Bone Marrow Specimens. Pediatr Dev Pathol. 2016 May-Jun; 19(3):254-5. PMID: 26598932.
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      53. Doi T, Shimada H, Makizako H, Tsutsumimoto K, Hotta R, Nakakubo S, Suzuki T. Effects of white matter lesions on trunk stability during dual-task walking among older adults with mild cognitive impairment. Age (Dordr). 2015 Dec; 37(6):120. PMID: 26578460.
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      54. Makizako H, Tsutsumimoto K, Doi T, Hotta R, Nakakubo S, Liu-Ambrose T, Shimada H. Effects of exercise and horticultural intervention on the brain and mental health in older adults with depressive symptoms and memory problems: study protocol for a randomized controlled trial [UMIN000018547]. Trials. 2015; 16(1):499. PMID: 26537979.
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      55. Doi T, Verghese J, Shimada H, Makizako H, Tsutsumimoto K, Hotta R, Nakakubo S, Suzuki T. Motoric Cognitive Risk Syndrome: Prevalence and Risk Factors in Japanese Seniors. J Am Med Dir Assoc. 2015 Dec 1; 16(12):1103.e21-5. PMID: 26476498.
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      56. Tsutsumimoto K, Makizako H, Shimada H, Doi T, Suzuki T. Set-Shifting Ability Is Associated with Gray Matter Volume in Older People with Mild Cognitive Impairment. Dement Geriatr Cogn Dis Extra. 2015 Sep-Dec; 5(3):395-403. PMID: 26628898.
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      57. Kurosawa H, Tanizawa A, Tono C, Watanabe A, Shima H, Ito M, Yuza Y, Hotta N, Muramatsu H, Okada M, Kajiwara R, Moriya Saito A, Mizutani S, Adachi S, Horibe K, Ishii E, Shimada H. Leukostasis in Children and Adolescents with Chronic Myeloid Leukemia: Japanese Pediatric Leukemia/Lymphoma Study Group. Pediatr Blood Cancer. 2016 Mar; 63(3):406-11. PMID: 26485422.
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      58. Iwasa H, Masui Y, Inagaki H, Yoshida Y, Shimada H, Otsuka R, Kikuchi K, Nonaka K, Yoshida H, Yoshida H, Suzuki T. Development of the Japan Science and Technology Agency Index of Competence to Assess Functional Capacity in Older Adults: Conceptual Definitions and Preliminary Items. Gerontol Geriatr Med. 2015 Jan-Dec; 1:2333721415609490. PMID: 28138472.
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      59. Uemura K, Doi T, Shimada H, Makizako H, Park H, Suzuki T. Age-related changes in prefrontal oxygenation during memory encoding and retrieval. Geriatr Gerontol Int. 2016 Dec; 16(12):1296-1304. PMID: 26464006.
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      60. Makizako H, Shimada H, Tsutsumimoto K, Lee S, Doi T, Nakakubo S, Hotta R, Suzuki T. Social Frailty in Community-Dwelling Older Adults as a Risk Factor for Disability. J Am Med Dir Assoc. 2015 Nov 1; 16(11):1003.e7-1003.e11. PMID: 26482055.
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      61. Li J, Chang YC, Wu CH, Liu J, Kwon-Chung KJ, Huang SH, Shimada H, Fante R, Fu X, Jong A. The 14-3-3 gene function of Cryptococcus neoformans is required for its growth and virulence. J Microbiol Biotechnol. 2015 Oct 6. PMID: 26437944.
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      62. Doi T, Shimada H, Makizako H, Tsutsumimoto K, Hotta R, Nakakubo S, Suzuki T. Insulin-Like Growth Factor-1 Related to Disability Among Older Adults. J Gerontol A Biol Sci Med Sci. 2016 Jun; 71(6):797-802. PMID: 26424830.
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      63. Tsutsumimoto K, Doi T, Shimada H, Makizako H, Hotta R, Nakakubo S, Suzuki T. Combined Effect of Slow Gait Speed and Depressive Symptoms on Incident Disability in Older Adults. J Am Med Dir Assoc. 2016 Feb 1; 17(2):123-7. PMID: 26412017.
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      64. Uemura K, Shimada H, Doi T, Makizako H, Tsutsumimoto K, Park H, Suzuki T. Reduced prefrontal oxygenation in mild cognitive impairment during memory retrieval. Int J Geriatr Psychiatry. 2016 Jun; 31(6):583-91. PMID: 26387497.
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      65. Makizako H, Shimada H, Doi T, Tsutsumimoto K, Suzuki T. Impact of physical frailty on disability in community-dwelling older adults: a prospective cohort study. BMJ Open. 2015; 5(9):e008462. PMID: 26338685.
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      66. Makizako H, Shimada H, Doi T, Tsutsumimoto K, Lee S, Suzuki T. Onset of Disability According to Mild Cognitive Impairment Subtype in Community-Dwelling Older Adults in Japan. J Am Geriatr Soc. 2015 Sep; 63(9):1959-61. PMID: 26389994.
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      67. Manabe A, Shimada H, Hattori T, Nakashizuka H, Yuzawa M. RANDOMIZED CONTROLLED STUDY OF INTRAVITREAL BEVACIZUMAB 0.16 MG INJECTED ONE DAY BEFORE SURGERY FOR PROLIFERATIVE DIABETIC RETINOPATHY. Retina. 2015 Sep; 35(9):1800-7. PMID: 25932549.
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      68. Doi T, Shimada H, Makizako H, Tsutsumimoto K, Hotta R, Nakakubo S, Suzuki T. Mild Cognitive Impairment, Slow Gait, and Risk of Disability: A Prospective Study. J Am Med Dir Assoc. 2015 Dec 1; 16(12):1082-6. PMID: 26298802.
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      69. Venkatramani R, Triche TJ, Wang L, Shimada H, Mascarenhas L. Insulin-like Growth Factor 2 Gene Expression Molecularly Differentiates Pleuropulmonary Blastoma and Embryonal Rhabdomyosarcoma. J Pediatr Hematol Oncol. 2015 Aug; 37(6):e356-60. PMID: 26056800.
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      70. Kojima N, Kim M, Saito K, Yoshida H, Yoshida Y, Hirano H, Obuchi S, Shimada H, Suzuki T, Kim H. Lifestyle-Related Factors Contributing to Decline in Knee Extension Strength among Elderly Women: A Cross-Sectional and Longitudinal Cohort Study. PLoS One. 2015; 10(7):e0132523. PMID: 26177292.
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      71. Shimada H, Uemura K, Makizako H, Doi T, Lee S, Suzuki T. Performance on the flanker task predicts driving cessation in older adults. Int J Geriatr Psychiatry. 2016 Feb; 31(2):169-75. PMID: 26095520.
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      72. Tsutsumimoto K, Doi T, Shimada H, Makizako H, Yoshida D, Uemura K, Anan Y, Park H, Suzuki T. Self-reported exhaustion associated with physical activity among older adults. Geriatr Gerontol Int. 2016 May; 16(5):625-30. PMID: 26044450.
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      73. Nakashizuka H, Shimada H, Hattori T, Yamamoto A, Tanaka K, Kitagawa Y, Yuzawa M. [Incidence of Postoperative Retinal Detachment after 25-gauge Vitrectomy for Macular Diseases]. Nihon Ganka Gakkai Zasshi. 2015 Jun; 119(6):402-9. PMID: 26214891.
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      74. Nakashizuka H, Shimada H, Hattori T, Noguchi T, Kokubo N, Yuzawa M. Vitrectomy using 0.025% povidone-iodine in balanced salt solution plus for the treatment of postoperative endophthalmitis. Retina. 2015 Jun; 35(6):1087-94. PMID: 25946690.
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      75. Challagundla KB, Wise PM, Neviani P, Chava H, Murtadha M, Xu T, Kennedy R, Ivan C, Zhang X, Vannini I, Fanini F, Amadori D, Calin GA, Hadjidaniel M, Shimada H, Jong A, Seeger RC, Asgharzadeh S, Goldkorn A, Fabbri M. Exosome-Mediated Transfer of microRNAs Within the Tumor Microenvironment and Neuroblastoma Resistance to Chemotherapy. J Natl Cancer Inst. 2015 Jul; 107(7). PMID: 25972604.
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      76. Shimada H, Tsutsumimoto K, Lee S, Doi T, Makizako H, Lee S, Harada K, Hotta R, Bae S, Nakakubo S, Uemura K, Park H, Suzuki T. Driving continuity in cognitively impaired older drivers. Geriatr Gerontol Int. 2016 Apr; 16(4):508-14. PMID: 25953032.
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      77. Shimada H, Minami H, Okuizumi N, Sakuma I, Ukai M, Fujii K, Yokoya A, Fukuda Y, Saitoh Y. Nitrogen K-edge x-ray absorption near edge structure of pyrimidine-containing nucleotides in aqueous solution. J Chem Phys. 2015 May 7; 142(17):175102. PMID: 25956126.
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      78. Hotta R, Doi T, Shimada H, Makizako H, Yoshida D, Anan Y, Tsutsumimoto K, Uemura K, Park H, Suzuki T. Cigarette smoking and cognitive health in elderly Japanese. Am J Health Behav. 2015 May; 39(3):294-300. PMID: 25741674.
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      79. Shimada H, Makizako H, Doi T, Tsutsumimoto K, Suzuki T. Incidence of Disability in Frail Older Persons With or Without Slow Walking Speed. J Am Med Dir Assoc. 2015 Aug 1; 16(8):690-6. PMID: 25922120.
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      80. Makizako H, Shimada H, Doi T, Tsutsumimoto K, Lee S, Hotta R, Nakakubo S, Harada K, Lee S, Bae S, Harada K, Suzuki T. Cognitive functioning and walking speed in older adults as predictors of limitations in self-reported instrumental activity of daily living: prospective findings from the obu study of health promotion for the elderly. Int J Environ Res Public Health. 2015; 12(3):3002-13. PMID: 25768239.
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      81. DuBois SG, Groshen S, Park JR, Haas-Kogan DA, Yang X, Geier E, Chen E, Giacomini K, Weiss B, Cohn SL, Granger MM, Yanik GA, Hawkins R, Courtier J, Jackson H, Goodarzian F, Shimada H, Czarnecki S, Tsao-Wei D, Villablanca JG, Marachelian A, Matthay KK. Phase I Study of Vorinostat as a Radiation Sensitizer with 131I-Metaiodobenzylguanidine (131I-MIBG) for Patients with Relapsed or Refractory Neuroblastoma. Clin Cancer Res. 2015 Jun 15; 21(12):2715-21. PMID: 25695691.
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      82. Lee S, Shimada H, Park H, Makizako H, Lee S, Doi T, Yoshida D, Tsutsumimoto K, Anan Y, Suzuki T. The Association Between Kidney Function and Cognitive Decline in Community-Dwelling, Elderly Japanese People. J Am Med Dir Assoc. 2015 Apr 1; 16(4):349.e1-5. PMID: 25669668.
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      83. Manabe A, Kawasaki H, Shimada H, Kato I, Kodama Y, Sato A, Matsumoto K, Kato K, Yabe H, Kudo K, Kato M, Saito T, Saito AM, Tsurusawa M, Horibe K. Imatinib use immediately before stem cell transplantation in children with Philadelphia chromosome-positive acute lymphoblastic leukemia: Results from Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) Study Ph(+) ALL04. Cancer Med. 2015 May; 4(5):682-9. PMID: 25641907.
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      84. Yanik GA, Villablanca JG, Maris JM, Weiss B, Groshen S, Marachelian A, Park JR, Tsao-Wei D, Hawkins R, Shulkin BL, Jackson H, Goodarzian F, Shimada H, Courtier J, Hutchinson R, Haas-Koga D, Hasenauer CB, Czarnecki S, Katzenstein HM, Matthay KK. (131)I-Metaiodobenzylguanidine with Intensive Chemotherapy and Autologous Stem Cell Transplantation for High-Risk Neuroblastoma. A New Approaches to Neuroblastoma Therapy (NANT) Phase II Study. Biol Blood Marrow Transplant. 2015 Apr; 21(4):673-81. PMID: 25639769.
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      85. Harada K, Lee S, Park H, Shimada H, Makizako H, Doi T, Yoshida D, Tsutsumimoto K, Anan Y, Uemura K, Suzuki T. Going outdoors and cognitive function among community-dwelling older adults: Moderating role of physical function. Geriatr Gerontol Int. 2016 Jan; 16(1):65-73. PMID: 25597479.
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      86. Kutoku Y, Ohsawa Y, Kuwano R, Ikeuchi T, Inoue H, Ataka S, Shimada H, Mori H, Sunada Y. A Second Pedigree with Amyloid-less Familial Alzheimer's Disease Harboring an Identical Mutation in the Amyloid Precursor Protein Gene (E693delta). Intern Med. 2015; 54(2):205-8. PMID: 25743013.
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      87. Grant CN, Mojica SG, Sala FG, Hill JR, Levin DE, Speer AL, Barthel ER, Shimada H, Zachos NC, Grikscheit TC. Human and mouse tissue-engineered small intestine both demonstrate digestive and absorptive function. Am J Physiol Gastrointest Liver Physiol. 2015 Apr 15; 308(8):G664-77. PMID: 25573173.
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      88. Tsutsumimoto K, Doi T, Shimada H, Makizako H, Uemura K, Ando H, Suzuki T. Self-reported Exhaustion is Associated with Small Life Space in Older Adults with Mild Cognitive Impairment. J Phys Ther Sci. 2014 Dec; 26(12):1979-83. PMID: 25540512.
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      89. Doi T, Makizako H, Shimada H, Tsutsumimoto K, Hotta R, Nakakubo S, Park H, Suzuki T. Objectively measured physical activity, brain atrophy, and white matter lesions in older adults with mild cognitive impairment. Exp Gerontol. 2015 Feb; 62:1-6. PMID: 25528600.
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      90. Yamamoto K, Koh H, Shimada H, Takeuchi J, Yamakawa Y, Kawamura M, Miki T. Cerebral infarction in the left hemisphere compared with the right hemisphere increases the risk of aspiration pneumonia. Osaka City Med J. 2014 Dec; 60(2):81-6. PMID: 25803883.
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      91. Kim H, Suzuki T, Kim M, Kojima N, Yoshida Y, Hirano H, Saito K, Iwasa H, Shimada H, Hosoi E, Yoshida H. Incidence and predictors of sarcopenia onset in community-dwelling elderly Japanese women: 4-year follow-up study. J Am Med Dir Assoc. 2015 Jan 1; 16(1):85.e1-8. PMID: 25458445.
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      92. Yamazaki F, Osumi T, Shigematsu N, Morioka H, Shimada H. Successful treatment of metastatic rhabdomyosarcoma with radiochemotherapy and allogeneic hematopoietic stem cell transplantation. Jpn J Clin Oncol. 2015 Feb; 45(2):225-8. PMID: 25398582.
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      93. Doi T, Shimada H, Park H, Makizako H, Tsutsumimoto K, Uemura K, Nakakubo S, Hotta R, Suzuki T. Cognitive function and falling among older adults with mild cognitive impairment and slow gait. Geriatr Gerontol Int. 2015 Aug; 15(8):1073-8. PMID: 25363419.
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      94. Doi T, Shimada H, Makizako H, Tsutsumimoto K, Hotta R, Nakakubo S, Suzuki T. Association of insulin-like growth factor-1 with mild cognitive impairment and slow gait speed. Neurobiol Aging. 2015 Feb; 36(2):942-7. PMID: 25467636.
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      95. Ihira H, Furuna T, Mizumoto A, Makino K, Saitoh S, Ohnishi H, Shimada H, Makizako H. Subjective physical and cognitive age among community-dwelling older people aged 75 years and older: differences with chronological age and its associated factors. Aging Ment Health. 2015 Aug; 19(8):756-61. PMID: 25307795.
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      96. Makizako H, Shimada H, Doi T, Yoshida D, Anan Y, Tsutsumimoto K, Uemura K, Liu-Ambrose T, Park H, Lee S, Suzuki T. Physical frailty predicts incident depressive symptoms in elderly people: prospective findings from the obu study of health promotion for the elderly. J Am Med Dir Assoc. 2015 Mar; 16(3):194-9. PMID: 25307294.
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      97. Hasebe M, Kanda S, Shimada H, Akazome Y, Abe H, Oka Y. Kiss1 neurons drastically change their firing activity in accordance with the reproductive state: insights from a seasonal breeder. Endocrinology. 2014 Dec; 155(12):4868-80. PMID: 25247469.
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      98. Teshiba R, Kawano S, Wang LL, He L, Naranjo A, London WB, Seeger RC, Gastier-Foster JM, Look AT, Hogarty MD, Cohn SL, Maris JM, Park JR, Shimada H. Age-Dependent Prognostic Effect by Mitosis-Karyorrhexis Index in Neuroblastoma: A Report from the Children's Oncology Group. Pediatr Dev Pathol. 2014 Nov-Dec; 17(6):441-9. PMID: 25207821.
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      99. Solari V, Borriello L, Turcatel G, Shimada H, Sposto R, Fernandez GE, Asgharzadeh S, Yates EA, Turnbull JE, DeClerck YA. MYCN-Dependent Expression of Sulfatase-2 Regulates Neuroblastoma Cell Survival. Cancer Res. 2014 Nov 1; 74(21):5999-6009. PMID: 25164011.
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      100. Shimada H. Basic setup and disinfection. Dev Ophthalmol. 2014; 54:63-70. PMID: 25196753.
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      101. Makizako H, Liu-Ambrose T, Shimada H, Doi T, Park H, Tsutsumimoto K, Uemura K, Suzuki T. Moderate-intensity physical activity, hippocampal volume, and memory in older adults with mild cognitive impairment. J Gerontol A Biol Sci Med Sci. 2015 Apr; 70(4):480-6. PMID: 25147086.
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      102. Shimada H, Fukao T, Minami H, Ukai M, Fujii K, Yokoya A, Fukuda Y, Saitoh Y. Nitrogen K-edge X-ray absorption near edge structure (XANES) spectra of purine-containing nucleotides in aqueous solution. J Chem Phys. 2014 Aug 7; 141(5):055102. PMID: 25106615.
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      103. Ashitaka Y, Shimada H. Acquisition process of typing skill using hierarchical materials in the Japanese language. Atten Percept Psychophys. 2014 Aug; 76(6):1838-46. PMID: 24874261.
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      104. Uemura K, Shimada H, Doi T, Makizako H, Park H, Suzuki T. Depressive symptoms in older adults are associated with decreased cerebral oxygenation of the prefrontal cortex during a trail-making test. Arch Gerontol Geriatr. 2014 Sep-Oct; 59(2):422-8. PMID: 25064032.
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      105. Shimada H, Park H, Makizako H, Doi T, Lee S, Suzuki T. Depressive symptoms and cognitive performance in older adults. J Psychiatr Res. 2014 Oct; 57:149-56. PMID: 25023083.
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      106. Doi T, Shimada H, Makizako H, Tsutsumimoto K, Uemura K, Suzuki T. Apolipoprotein?E genotype and physical function among older people with mild cognitive impairment. Geriatr Gerontol Int. 2015 Apr; 15(4):422-7. PMID: 24730603.
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      107. Shimada H, Makizako H, Doi T, Yoshida D, Tsutsumimoto K, Anan Y, Uemura K, Lee S, Park H, Suzuki T. A large, cross-sectional observational study of serum BDNF, cognitive function, and mild cognitive impairment in the elderly. Front Aging Neurosci. 2014; 6:69. PMID: 24782766.
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      108. Doi T, Shimada H, Makizako H, Tsutsumimoto K, Uemura K, Anan Y, Suzuki T. Cognitive function and gait speed under normal and dual-task walking among older adults with mild cognitive impairment. BMC Neurol. 2014; 14(1):67. PMID: 24694100.
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      109. Morgenstern DA, London WB, Stephens D, Volchenboum SL, Hero B, Di Cataldo A, Nakagawara A, Shimada H, Ambros PF, Matthay KK, Cohn SL, Pearson AD, Irwin MS. Metastatic Neuroblastoma Confined to Distant Lymph Nodes (stage 4N) Predicts Outcome in Patients With Stage 4 Disease: A Study From the International Neuroblastoma Risk Group Database. J Clin Oncol. 2014 Apr 20; 32(12):1228-35. PMID: 24663047.
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      110. Martin A, Schneiderman J, Helenowski IB, Morgan E, Dilley K, Danner-Koptik K, Hatahet M, Shimada H, Cohn SL, Kletzel M, Hijiya N. Secondary malignant neoplasms after high-dose chemotherapy and autologous stem cell rescue for high-risk neuroblastoma. Pediatr Blood Cancer. 2014 Aug; 61(8):1350-6. PMID: 24634399.
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      111. Uemura K, Shimada H, Makizako H, Doi T, Tsutsumimoto K, Yoshida D, Anan Y, Ito T, Lee S, Park H, Suzuki T. Effects of mild and global cognitive impairment on the prevalence of fear of falling in community-dwelling older adults. Maturitas. 2014 May; 78(1):62-6. PMID: 24685290.
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      112. Trost M, Shimada H. Hospitalists should have increased suspicion for primary ciliary dyskinesia in patients with congenital heart disease. Hosp Pediatr. 2014 Mar; 4(2):109-12. PMID: 24584982.
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      113. Yoshida D, Suzuki T, Shimada H, Park H, Makizako H, Doi T, Anan Y, Tsutsumimoto K, Uemura K, Ito T, Lee S. Using two different algorithms to determine the prevalence of sarcopenia. Geriatr Gerontol Int. 2014 Feb; 14 Suppl 1:46-51. PMID: 24450560.
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      114. Stricker TP, Morales La Madrid A, Chlenski A, Guerrero L, Salwen HR, Gosiengfiao Y, Perlman EJ, Furman W, Bahrami A, Shohet JM, Zage PE, Hicks MJ, Shimada H, Suganuma R, Park JR, So S, London WB, Pytel P, Maclean KH, Cohn SL. Validation of a prognostic multi-gene signature in high-risk neuroblastoma using the high throughput digital NanoString nCounter™ system. Mol Oncol. 2014 May; 8(3):669-78. PMID: 24560446.
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      115. Yoshida D, Shimada H, Park H, Anan Y, Ito T, Harada A, Suzuki T. Development of an equation for estimating appendicular skeletal muscle mass in Japanese older adults using bioelectrical impedance analysis. Geriatr Gerontol Int. 2014 Oct; 14(4):851-7. PMID: 24450604.
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      116. Makizako H, Shimada H, Doi T, Yoshida D, Tsutsumimoto K, Uemura K, Anan Y, Park H, Lee S, Ito T, Suzuki T. The combined status of physical performance and depressive symptoms is strongly associated with a history of falling in community-dwelling elderly: Cross-sectional findings from the Obu Study of Health Promotion for the Elderly (OSHPE). Arch Gerontol Geriatr. 2014 May-Jun; 58(3):327-31. PMID: 24525136.
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      117. Snyder KM, Ashitaka Y, Shimada H, Ulrich JE, Logan GD. What skilled typists don't know about the QWERTY keyboard. Atten Percept Psychophys. 2014 Jan; 76(1):162-71. PMID: 24101344.
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      118. Hato S, Suzukawa M, Hayashi Y, Shimada H. Factors associated with the level of disability in elderly adults based on the Japanese long-term care insurance system. Nihon Ronen Igakkai Zasshi. 2014; 51(1):69-73. PMID: 24747503.
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      119. Bishop MW, Yin H, Shimada H, Towbin AJ, Miethke A, Weiss B. Management of Stage 4S Composite Neuroblastoma With a MYCN-amplified Nodule. J Pediatr Hematol Oncol. 2014 Jan; 36(1):e31-5. PMID: 23528904.
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      120. Yagasaki H, Shichino H, Ohara A, Kobayashi R, Yabe H, Ohga S, Hamamoto K, Ohtsuka Y, Shimada H, Inoue M, Muramatsu H, Takahashi Y, Kojima S. Immunosuppressive therapy with horse anti-thymocyte globulin and cyclosporine as treatment for fulminant aplastic anemia in children. Ann Hematol. 2014 May; 93(5):747-52. PMID: 24337487.
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      121. Shima H, Yamagata K, Aikawa Y, Shino M, Koseki H, Shimada H, Kitabayashi I. Bromodomain-PHD finger protein 1 is critical for leukemogenesis associated with MOZ-TIF2 fusion. Int J Hematol. 2014 Jan; 99(1):21-31. PMID: 24258712.
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      122. Teshiba R, Sartelet H, Shimada H. Neuroblastoma or not neuroblastoma. Hum Pathol. 2014 Mar; 45(3):662-3. PMID: 24529334.
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      123. Ashitaka Y, Shimada H. The cultural background of the non-academic concept of psychology in Japan: Its implications for introductory education in psychology. Int J Psychol. 2014 Jun; 49(3):167-74. PMID: 24821505.
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      124. Kojima N, Kim H, Saito K, Yoshida H, Yoshida Y, Hirano H, Obuchi S, Shimada H, Suzuki T. Association of knee-extension strength with instrumental activities of daily living in community-dwelling older adults. Geriatr Gerontol Int. 2014 Jul; 14(3):674-80. PMID: 24215603.
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      125. Makizako M, Makizako H, Doi T, Uemura K, Tsutsumimoto K, Miyaguchi H, Shimada H. Olfactory identification and cognitive performance in community-dwelling older adults with mild cognitive impairment. Chem Senses. 2014 Jan; 39(1):39-46. PMID: 24200528.
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      126. Sai A, Shimono T, Sakai K, Takeda A, Shimada H, Tsukamoto T, Maeda H, Sakamoto S, Miki Y. Diffusion-weighted imaging thermometry in multiple sclerosis. J Magn Reson Imaging. 2014 Sep; 40(3):649-54. PMID: 24925253.
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      127. Doi T, Shimada H, Makizako H, Lee S, Park H, Tsutsumimoto K, Uemura K, Yoshida D, Anan Y, Suzuki T. Cognitive activities and instrumental activity of daily living in older adults with mild cognitive impairment. Dement Geriatr Cogn Dis Extra. 2013; 3(1):398-406. PMID: 24348501.
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      128. Kiyokawa N, Iijima K, Tomita O, Miharu M, Hasegawa D, Kobayashi K, Okita H, Kajiwara M, Shimada H, Inukai T, Makimoto A, Fukushima T, Nanmoku T, Koh K, Manabe A, Kikuchi A, Sugita K, Fujimoto J, Hayashi Y, Ohara A. Significance of CD66c expression in childhood acute lymphoblastic leukemia. Leuk Res. 2014 Jan; 38(1):42-8. PMID: 24231528.
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      129. Takeda A, Shimada H, Tamura A, Yasui M, Yamamoto K, Itoh K, Ataka S, Tanaka S, Ohsawa M, Hatsuta H, Hirano M, Sakamoto H, Ueno S, Nakamura Y, Tsutada T, Miki T. A case of anti-N-methyl-d-aspartate receptor encephalitis with multiple sclerosis-like demyelinated lesions. Mult Scler Relat Disord. 2014 May; 3(3):391-7. PMID: 25876479.
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      130. Shimada H. [The DIAN Study]. Brain Nerve. 2013 Oct; 65(10):1179-84. PMID: 24101429.
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      131. Yamazaki F, Nakazawa A, Osumi T, Shimojima N, Tanaka T, Nakagawara A, Shimada H. Two cases of neuroblastoma comprising two distinct clones. Pediatr Blood Cancer. 2014 Apr; 61(4):760-2. PMID: 24108545.
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      132. Yamamoto K, Shimada H, Koh H, Ataka S, Miki T. Serum levels of albumin-amyloid beta complexes are decreased in Alzheimer's disease. Geriatr Gerontol Int. 2014 Jul; 14(3):716-23. PMID: 24020590.
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      133. Lou S, Liu G, Shimada H, Yang X, He Q, Wu L. The lost intrinsic fragmentation of MAT1 protein during granulopoiesis promotes the growth and metastasis of leukemic myeloblasts. Stem Cells. 2013 Sep; 31(9):1942-53. PMID: 23765726.
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      134. Makizako H, Shimada H, Doi T, Park H, Yoshida D, Suzuki T. Six-minute walking distance correlated with memory and brain volume in older adults with mild cognitive impairment: a voxel-based morphometry study. Dement Geriatr Cogn Dis Extra. 2013; 3(1):223-32. PMID: 24052797.
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      135. Doi T, Makizako H, Shimada H, Park H, Tsutsumimoto K, Uemura K, Suzuki T. Brain activation during dual-task walking and executive function among older adults with mild cognitive impairment: a fNIRS study. Aging Clin Exp Res. 2013 Oct; 25(5):539-44. PMID: 23949972.
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      136. Makizako H, Shimada H, Doi T, Park H, Yoshida D, Uemura K, Tsutsumimoto K, Liu-Ambrose T, Suzuki T. Poor balance and lower gray matter volume predict falls in older adults with mild cognitive impairment. BMC Neurol. 2013; 13(1):102. PMID: 23915144.
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      137. Wang LL, Suganuma R, Ikegaki N, Tang X, Naranjo A, McGrady P, London WB, Hogarty MD, Gastier-Foster JM, Look AT, Park JR, Maris JM, Cohn SL, Seeger RC, Shimada H. Neuroblastoma of undifferentiated subtype, prognostic significance of prominent nucleolar formation, and MYC/MYCN protein expression: a report from the Children's Oncology Group. Cancer. 2013 Oct 15; 119(20):3718-26. PMID: 23901000.
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      138. Hashidate H, Shimada H, Shiomi T, Shibata M, Sawada K, Sasamoto N. Measuring indoor life-space mobility at home in older adults with difficulty to perform outdoor activities. J Geriatr Phys Ther. 2013 Jul-Sep; 36(3):109-14. PMID: 22976813.
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      139. Maurer BJ, Kang MH, Villablanca JG, Janeba J, Groshen S, Matthay KK, Sondel PM, Maris JM, Jackson HA, Goodarzian F, Shimada H, Czarnecki S, Hasenauer B, Reynolds CP, Marachelian A. Phase I trial of fenretinide delivered orally in a novel organized lipid complex in patients with relapsed/refractory neuroblastoma: a report from the New Approaches to Neuroblastoma Therapy (NANT) consortium. Pediatr Blood Cancer. 2013 Nov; 60(11):1801-8. PMID: 23813912.
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      140. Shimada H, Nakashizuka H, Hattori T, Otani K, Manabe A, Kitagawa Y, Yuzawa M. Prophylaxis for acute scleral buckle infection using 0.25 % povidone-iodine ocular surface irrigation during surgery. Int Ophthalmol. 2014 Apr; 34(2):211-6. PMID: 23807149.
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      141. Osumi T, Miharu M, Saji H, Kusunoki Y, Kojima H, Nakamura J, Shimada H. Nonsense mutation in HLA-B*40:02 in a case with acquired aplastic anaemia: a possible origin of clonal escape from autoimmune insult. Br J Haematol. 2013 Sep; 162(5):706-7. PMID: 23701165.
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      142. Osumi T, Awazu M, Fujimura E, Yamazaki F, Hashiguchi A, Shimada H. Leukemia kidney infiltration can cause secondary polycythemia by activating hypoxia-inducible factor (HIF) pathway. Eur J Pediatr. 2013 Jun; 172(6):829-32. PMID: 23677251.
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      143. Shimada H, Makizako H, Doi T, Yoshida D, Tsutsumimoto K, Anan Y, Uemura K, Ito T, Lee S, Park H, Suzuki T. Combined prevalence of frailty and mild cognitive impairment in a population of elderly Japanese people. J Am Med Dir Assoc. 2013 Jul; 14(7):518-24. PMID: 23669054.
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      144. Ara T, Nakata R, Sheard MA, Shimada H, Buettner R, Groshen SG, Ji L, Yu H, Jove R, Seeger RC, DeClerck YA. Critical role of STAT3 in IL-6-mediated drug resistance in human neuroblastoma. Cancer Res. 2013 Jul 1; 73(13):3852-64. PMID: 23633489.
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      145. Kashiwagi H, Kunishima S, Kiyomizu K, Amano Y, Shimada H, Morishita M, Kanakura Y, Tomiyama Y. Demonstration of novel gain-of-function mutations of aIIbß3: association with macrothrombocytopenia and glanzmann thrombasthenia-like phenotype. Mol Genet Genomic Med. 2013 Jul; 1(2):77-86. PMID: 24498605.
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      146. Shimada H, Suzuki T, Suzukawa M, Makizako H, Doi T, Yoshida D, Tsutsumimoto K, Anan Y, Uemura K, Ito T, Lee S, Park H. Performance-based assessments and demand for personal care in older Japanese people: a cross-sectional study. BMJ Open. 2013; 3(4). PMID: 23578683.
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      147. Suzuki T, Shimada H, Makizako H, Doi T, Yoshida D, Ito K, Shimokata H, Washimi Y, Endo H, Kato T. A randomized controlled trial of multicomponent exercise in older adults with mild cognitive impairment. PLoS One. 2013; 8(4):e61483. PMID: 23585901.
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      148. Yamazaki F, Osumi T, Kosaki K, Mikami S, Hirato J, Shimada H. Large congenital melanocytic nevi with atypical teratoid/rhabdoid tumor. Pediatr Blood Cancer. 2013 Jul; 60(7):1240-1. PMID: 23519929.
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      149. Ikegaki N, Shimada H, Fox AM, Regan PL, Jacobs JR, Hicks SL, Rappaport EF, Tang XX. Transient treatment with epigenetic modifiers yields stable neuroblastoma stem cells resembling aggressive large-cell neuroblastomas. Proc Natl Acad Sci U S A. 2013 Apr 9; 110(15):6097-102. PMID: 23479628.
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      150. Shimada H, Hattori T, Mori R, Nakashizuka H, Fujita K, Yuzawa M. Minimizing the endophthalmitis rate following intravitreal injections using 0.25% povidone-iodine irrigation and surgical mask. Graefes Arch Clin Exp Ophthalmol. 2013 Aug; 251(8):1885-90. PMID: 23389553.
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      151. Uemura K, Shimada H, Makizako H, Doi T, Yoshida D, Tsutsumimoto K, Anan Y, Suzuki T. Cognitive function affects trainability for physical performance in exercise intervention among older adults with mild cognitive impairment. Clin Interv Aging. 2013; 8:97-102. PMID: 23390362.
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      152. Hsieh YT, Gang EJ, Geng H, Park E, Huantes S, Chudziak D, Dauber K, Schaefer P, Scharman C, Shimada H, Shojaee S, Klemm L, Parameswaran R, Loh M, Kang ES, Koo HH, Hofmann WK, Andrade J, Crooks GM, Willman CL, Müschen M, Papayannopoulou T, Heisterkamp N, Bönig H, Kim YM. Integrin alpha4 blockade sensitizes drug resistant pre-B acute lymphoblastic leukemia to chemotherapy. Blood. 2013 Mar 7; 121(10):1814-8. PMID: 23319569.
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      153. Giuliani S, Marachelian A, Franklin A, Shimada H, Grikscheit T. Forearm skeletal muscle neuroblastoma in a child: a rare primary location. J Pediatr Hematol Oncol. 2013 Jan; 35(1):61-3. PMID: 23249961.
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      154. Shimada H, Nakashizuka H, Hattori T, Mori R, Mizutani Y, Yuzawa M. Reduction of vitreous contamination rate after 25-gauge vitrectomy by surface irrigation with 0.25% povidone-iodine. Retina. 2013 Jan; 33(1):143-51. PMID: 22972447.
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      155. Kim H, Suzuki T, Yoshida H, Shimada H, Yamashiro Y, Sudo M, Niki Y. [Are gait parameters related to knee pain, urinary incontinence and a history of falls in community-dwelling elderly women?]. Nihon Ronen Igakkai Zasshi. 2013; 50(4):528-35. PMID: 24047669.
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      156. Shimada H, Ishii K, Ishiwata K, Oda K, Suzukawa M, Makizako H, Doi T, Suzuki T. Gait adaptability and brain activity during unaccustomed treadmill walking in healthy elderly females. Gait Posture. 2013 Jun; 38(2):203-8. PMID: 23266043.
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      157. Ding W, Shimada H, Li L, Mittal R, Zhang X, Shudo K, He Q, Prasadarao NV, Wu L. Retinoid agonist Am80-enhanced neutrophil bactericidal activity arising from granulopoiesis in vitro and in a neutropenic mouse model. Blood. 2013 Feb 7; 121(6):996-1007. PMID: 23243275.
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      158. Makizako H, Shimada H, Park H, Doi T, Yoshida D, Uemura K, Tsutsumimoto K, Suzuki T. Evaluation of multidimensional neurocognitive function using a tablet personal computer: test-retest reliability and validity in community-dwelling older adults. Geriatr Gerontol Int. 2013 Oct; 13(4):860-6. PMID: 23230988.
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      159. Joshi VV, Shimada H. Primary renal neuroblastoma. Am J Surg Pathol. 2012 Dec; 36(12):1904-5; author reply 1905. PMID: 23026938.
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      160. Makizako H, Doi T, Shimada H, Yoshida D, Tsutsumimoto K, Uemura K, Suzuki T. Does a multicomponent exercise program improve dual-task performance in amnestic mild cognitive impairment? A randomized controlled trial. Aging Clin Exp Res. 2012 Dec; 24(6):640-6. PMID: 23211228.
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      161. Jarzembowski JA, Lal DR, Shimada H. Re: Needle core vs open biopsy for diagnosis of intermediate- and high-risk neuroblastoma in children. J Pediatr Surg. 2012 Nov; 47(11):2162-3; author reply 2163-5. PMID: 23164019.
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      162. Suzuki T, Shimada H, Makizako H, Doi T, Yoshida D, Tsutsumimoto K, Anan Y, Uemura K, Lee S, Park H. Effects of multicomponent exercise on cognitive function in older adults with amnestic mild cognitive impairment: a randomized controlled trial. BMC Neurol. 2012; 12:128. PMID: 23113898.
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      163. Uemura K, Doi T, Shimada H, Makizako H, Yoshida D, Tsutsumimoto K, Anan Y, Suzuki T. Effects of exercise intervention on vascular risk factors in older adults with mild cognitive impairment: a randomized controlled trial. Dement Geriatr Cogn Dis Extra. 2012 Jan; 2(1):445-55. PMID: 23189083.
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      164. Doi T, Makizako H, Shimada H, Yoshida D, Tsutsumimoto K, Sawa R, Misu S, Suzuki T. Effects of multicomponent exercise on spatial-temporal gait parameters among the elderly with amnestic mild cognitive impairment (aMCI): preliminary results from a randomized controlled trial (RCT). Arch Gerontol Geriatr. 2013 Jan-Feb; 56(1):104-8. PMID: 23063111.
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      165. Tamura A, Sonoo M, Hoshino S, Iwanami T, Shimada H, Miki T, Shimizu T. Stimulus duration and pain in nerve conduction studies. Muscle Nerve. 2013 Jan; 47(1):12-6. PMID: 23042136.
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      166. Yoshida GJ, Fuchimoto Y, Osumi T, Shimada H, Hosaka S, Morioka H, Mukai M, Masugi Y, Sakamoto M, Kuroda T. Li-Fraumeni syndrome with simultaneous osteosarcoma and liver cancer: increased expression of a CD44 variant isoform after chemotherapy. BMC Cancer. 2012; 12:444. PMID: 23031740.
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      167. Miyake Y, Tanaka K, Fukushima W, Kiyohara C, Sasaki S, Tsuboi Y, Yamada T, Oeda T, Shimada H, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M. Lack of association between BST1 polymorphisms and sporadic Parkinson's disease in a Japanese population. J Neurol Sci. 2012 Dec 15; 323(1-2):162-6. PMID: 23026536.
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      168. Makizako H, Doi T, Shimada H, Park H, Uemura K, Yoshida D, Tsutsumimoto K, Anan Y, Suzuki T. Relationship between going outdoors daily and activation of the prefrontal cortex during verbal fluency tasks (VFTs) among older adults: a near-infrared spectroscopy study. Arch Gerontol Geriatr. 2013 Jan-Feb; 56(1):118-23. PMID: 22995341.
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      169. Shimada H, Nakashizuka H, Hattori T, Kitagawa Y, Manabe A, Otani K, Yuzawa M. Reducing bacterial contamination inside fluid catch bag in 25-gauge vitrectomy by use of 0.25 % povidone-iodine ocular surface irrigation. Int Ophthalmol. 2013 Feb; 33(1):35-8. PMID: 22965271.
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      170. Kiyohara C, Miyake Y, Koyanagi M, Fujimoto T, Shirasawa S, Tanaka K, Fukushima W, Sasaki S, Tsuboi Y, Yamada T, Oeda T, Shimada H, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M. MDR1 C3435T polymorphism and interaction with environmental factors in risk of Parkinson's disease: a case-control study in Japan. Drug Metab Pharmacokinet. 2013; 28(2):138-43. PMID: 22971641.
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      171. Takeuchi J, Shimada H, Ataka S, Kawabe J, Mori H, Mizuno K, Wada Y, Shiomi S, Watanabe Y, Miki T. Clinical features of pittsburgh compound-B-negative dementia. Dement Geriatr Cogn Disord. 2012; 34(2):112-20. PMID: 22947919.
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      172. Asgharzadeh S, Salo JA, Ji L, Oberthuer A, Fischer M, Berthold F, Hadjidaniel M, Liu CW, Metelitsa LS, Pique-Regi R, Wakamatsu P, Villablanca JG, Kreissman SG, Matthay KK, Shimada H, London WB, Sposto R, Seeger RC. Clinical significance of tumor-associated inflammatory cells in metastatic neuroblastoma. J Clin Oncol. 2012 Oct 1; 30(28):3525-32. PMID: 22927533.
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      173. Osumi T, Miharu M, Fuchimoto Y, Morioka H, Kosaki K, Shimada H. The germline TP53 mutation c.722 C>T promotes bone and liver tumorigenesis at a young age. Pediatr Blood Cancer. 2012 Dec 15; 59(7):1332-3. PMID: 22887876.
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      174. Miyake Y, Tanaka K, Fukushima W, Kiyohara C, Sasaki S, Tsuboi Y, Yamada T, Oeda T, Shimada H, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M. UCHL1 S18Y variant is a risk factor for Parkinson's disease in Japan. BMC Neurol. 2012; 12:62. PMID: 22839974.
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      175. Honjo Y, Ito H, Horibe T, Shimada H, Nakanishi A, Mori H, Takahashi R, Kawakami K. Derlin-1-immunopositive inclusions in patients with Alzheimer's disease. Neuroreport. 2012 Jul 11; 23(10):611-5. PMID: 22627700.
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      176. Yoshimatsu T, Yoshida D, Shimada H, Komatsu T, Harada A, Suzuki T. Relationship between near-infrared spectroscopy, and subcutaneous fat and muscle thickness measured by ultrasonography in Japanese community-dwelling elderly. Geriatr Gerontol Int. 2013 Apr; 13(2):351-7. PMID: 22762795.
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      177. Suganuma R, Wang LL, Sano H, Naranjo A, London WB, Seeger RC, Hogarty MD, Gastier-Foster JM, Look AT, Park JR, Maris JM, Cohn SL, Amann G, Beiske K, Cullinane CJ, d'Amore ES, Gambini C, Jarzembowski JA, Joshi VV, Navarro S, Peuchmaur M, Shimada H. Peripheral neuroblastic tumors with genotype-phenotype discordance: a report from the Children's Oncology Group and the International Neuroblastoma Pathology Committee. Pediatr Blood Cancer. 2013 Mar; 60(3):363-70. PMID: 22744966.
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      178. Makizako H, Doi T, Shimada H, Yoshida D, Takayama Y, Suzuki T. Relationship between dual-task performance and neurocognitive measures in older adults with mild cognitive impairment. Geriatr Gerontol Int. 2013 Apr; 13(2):314-21. PMID: 22694665.
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      179. Matthay KK, Weiss B, Villablanca JG, Maris JM, Yanik GA, Dubois SG, Stubbs J, Groshen S, Tsao-Wei D, Hawkins R, Jackson H, Goodarzian F, Daldrup-Link H, Panigrahy A, Towbin A, Shimada H, Barrett J, Lafrance N, Babich J. Dose Escalation Study of No-Carrier-Added 131I-Metaiodobenzylguanidine for Relapsed or Refractory Neuroblastoma: New Approaches to Neuroblastoma Therapy Consortium Trial. J Nucl Med. 2012 Jul; 53(7):1155-63. PMID: 22700000.
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      180. Uemura K, Shimada H, Makizako H, Yoshida D, Doi T, Yamada M, Suzuki T. Factors associated with life-space in older adults with amnestic mild cognitive impairment. Geriatr Gerontol Int. 2013 Jan; 13(1):161-6. PMID: 22680286.
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      181. Doi T, Shimada H, Makizako H, Yoshida D, Shimokata H, Ito K, Washimi Y, Endo H, Suzuki T. Characteristics of cognitive function in early and late stages of amnestic mild cognitive impairment. Geriatr Gerontol Int. 2013 Jan; 13(1):83-9. PMID: 22672014.
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      182. Marachelian A, Shimada H, Sano H, Jackson H, Stein J, Sposto R, Matthay KK, Baker D, Villablanca JG. The significance of serial histopathology in a residual mass for outcome of intermediate risk stage 3 neuroblastoma. Pediatr Blood Cancer. 2012 May; 58(5):675-81. PMID: 22493777.
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      183. Strother DR, London WB, Schmidt ML, Brodeur GM, Shimada H, Thorner P, Collins MH, Tagge E, Adkins S, Reynolds CP, Murray K, Lavey RS, Matthay KK, Castleberry R, Maris JM, Cohn SL. Outcome After Surgery Alone or With Restricted Use of Chemotherapy for Patients With Low-Risk Neuroblastoma: Results of Children's Oncology Group Study P9641. J Clin Oncol. 2012 May 20; 30(15):1842-8. PMID: 22529259.
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      184. Tanaka R, Osumi T, Miharu M, Ishii T, Hasegawa T, Takahashi T, Shimada H. Hypoglycemia associated with L-asparaginase in acute lymphoblastic leukemia treatment: a case report. Exp Hematol Oncol. 2012; 1(1):8. PMID: 23211036.
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      185. Uemura K, Shimada H, Makizako H, Yoshida D, Doi T, Tsutsumimoto K, Suzuki T. A Lower Prevalence of Self-Reported Fear of Falling Is Associated with Memory Decline among Older Adults. Gerontology. 2012; 58(5):413-8. PMID: 22488205.
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      186. Wang L, He LJ, Shimada H. [Pathology of peripheral neuroblastic tumors]. Zhonghua Bing Li Xue Za Zhi. 2012 Apr; 41(4):283-7. PMID: 22800533.
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      187. Shinjoh M, Iketani O, Watanabe K, Shimojima N, Kudo M, Yamagishi H, Shimada H, Sugita K, Takahashi T, Mori T, Hasegawa N, Iwata S. Safety and efficacy of linezolid in 16 infants and children in Japan. J Infect Chemother. 2012 Aug; 18(4):591-6. PMID: 22460827.
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      188. Davidson TB, Sanchez-Lara PA, Randolph LM, Krieger MD, Wu SQ, Panigrahy A, Shimada H, Erdreich-Epstein A. Microdeletion del(22)(q12.2) encompassing the facial development-associated gene, MN1 (meningioma 1) in a child with Pierre-Robin sequence (including cleft palate) and neurofibromatosis 2 (NF2): a case report and review of the literature. BMC Med Genet. 2012; 13:19. PMID: 22436304.
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      189. Miyake Y, Tanaka K, Fukushima W, Kiyohara C, Sasaki S, Tsuboi Y, Yamada T, Oeda T, Shimada H, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M. SNCA polymorphisms, smoking, and sporadic Parkinson's disease in Japanese. Parkinsonism Relat Disord. 2012 Jun; 18(5):557-61. PMID: 22425546.
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      190. DuBois SG, Chesler L, Groshen S, Hawkins R, Goodarzian F, Shimada H, Yanik G, Tagen M, Stewart C, Mosse YP, Maris JM, Tsao-Wei D, Marachelian A, Villablanca JG, Matthay KK. Phase I study of vincristine, irinotecan, and ¹³¹I-metaiodobenzylguanidine for patients with relapsed or refractory neuroblastoma: a new approaches to neuroblastoma therapy trial. Clin Cancer Res. 2012 May 1; 18(9):2679-86. PMID: 22421195.
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      191. Yoshida D, Shimada H, Makizako H, Doi T, Ito K, Kato T, Shimokata H, Washimi Y, Endo H, Suzuki T. The relationship between atrophy of the medial temporal area and daily activities in older adults with mild cognitive impairment. Aging Clin Exp Res. 2012 Oct; 24(5):423-9. PMID: 22395286.
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      192. Silverman AM, Nakata R, Shimada H, Sposto R, Declerck YA. A galectin-3-dependent pathway upregulates interleukin-6 in the microenvironment of human neuroblastoma. Cancer Res. 2012 May 1; 72(9):2228-38. PMID: 22389450.
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      193. Shimada H, Nakashizuka H, Hattori T, Mori R, Mizutani Y, Yuzawa M. Clear visualization of anterior vitreous incarceration into cannulae during 25-gauge vitrectomy in eyes with asteroid hyalosis. Eur J Ophthalmol. 2012 Mar; 22(2):293-5. PMID: 21748727.
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      194. Yoshida D, Shimada H, Harada A, Matsui Y, Sakai Y, Suzuki T. Estimation of appendicular muscle mass and fat mass by near infrared spectroscopy in older persons. Geriatr Gerontol Int. 2012 Oct; 12(4):652-8. PMID: 22324754.
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      195. Shimada H. Imaging of glucose uptake during walking in elderly adults. Curr Aging Sci. 2012 Feb 1; 5(1):51-7. PMID: 21762089.
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      196. Shimada H, Kato T, Ito K, Makizako H, Doi T, Yoshida D, Shimokata H, Washimi Y, Endo H, Suzuki T. Relationship between Atrophy of the Medial Temporal Areas and Cognitive Functions in Elderly Adults with Mild Cognitive Impairment. Eur Neurol. 2012; 67(3):168-77. PMID: 22286117.
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      197. Tsutsumi R, Hanajima R, Hamada M, Shirota Y, Matsumoto H, Terao Y, Ohminami S, Yamakawa Y, Shimada H, Tsuji S, Ugawa Y. Reduced interhemispheric inhibition in mild cognitive impairment. Exp Brain Res. 2012 Apr; 218(1):21-6. PMID: 22234435.
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      198. Shimada H. Prevention of cognitive decline. Nihon Ronen Igakkai Zasshi. 2012; 49(1):60-2. PMID: 22466771.
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      199. Ohnuma T, Makizako H, Abe T, Miura H, Shimada H. [Predictors of interruptions to living at home in elderly people enrolled in a home visit rehabilitation service]. Nihon Ronen Igakkai Zasshi. 2012; 49(2):214-21. PMID: 23268871.
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      200. Shimada H. [Clinical characteristics of argyrophillic grain disease and senile dementia of the neurofibrillary tangle type]. Nihon Ronen Igakkai Zasshi. 2012; 49(3):281-3. PMID: 23268963.
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      201. Oya T, Uchiyama Y, Shimada H, Makizako H, Doi T, Yoshida D, Uemura K, Suzuki T. [Factors associated with fear of falling among community-dwelling elderly adults without reduced performance in instrumental activities of daily living]. Nihon Ronen Igakkai Zasshi. 2012; 49(4):457-62. PMID: 23269025.
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      202. Doi T, Makizako H, Shimada H, Yoshida D, Ito K, Kato T, Ando H, Suzuki T. Brain atrophy and trunk stability during dual-task walking among older adults. J Gerontol A Biol Sci Med Sci. 2012 Jun; 67(7):790-5. PMID: 22174190.
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      203. Angelini P, London WB, Cohn SL, Pearson AD, Matthay KK, Monclair T, Ambros PF, Shimada H, Leuschner I, Peuchmaur M, Irwin MS, Baruchel S. Characteristics and outcome of patients with ganglioneuroblastoma, nodular subtype: A report from the INRG project. Eur J Cancer. 2012 May; 48(8):1185-91. PMID: 22137163.
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      204. Makizako H, Shimada H, Doi T, Yoshida D, Ito K, Kato T, Shimokata H, Washimi Y, Endo H, Suzuki T. The association between decline in physical functioning and atrophy of medial temporal areas in community-dwelling older adults with amnestic and nonamnestic mild cognitive impairment. Arch Phys Med Rehabil. 2011 Dec; 92(12):1992-9. PMID: 22133247.
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      205. Krenova Z, Kren L, Blatny J, Falk M, Kazakov DV, Grossmann P, Shimada H, Sterba J. Extraosseal Ewing sarcoma as a rare cause of the blueberry muffin baby syndrome: a case report and the review of the literature. Am J Dermatopathol. 2011 Oct; 33(7):733-5. PMID: 21915035.
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      206. Saito K, Yokoyama T, Yoshida H, Kim H, Shimada H, Yoshida Y, Iwasa H, Shimizu Y, Kondo Y, Handa S, Maruyama N, Ishigami A, Suzuki T. A Significant Relationship between Plasma Vitamin C Concentration and Physical Performance among Japanese Elderly Women. J Gerontol A Biol Sci Med Sci. 2012 Mar; 67(3):295-301. PMID: 21934124.
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      207. Shimizu K, Ohoba H, Shimada H, Inoue Y, Jinn Y, Yoshimura N. [A case of Churg-Strauss syndrome with subarachnoid hemorrhage and left phrenic nerve paralysis]. Nihon Kokyuki Gakkai Zasshi. 2011 Sep; 49(9):642-6. PMID: 22073608.
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      208. Shimada H, Ataka S, Tomiyama T, Takechi H, Mori H, Miki T. Clinical course of patients with familial early-onset Alzheimer's disease potentially lacking senile plaques bearing the E693? mutation in amyloid precursor protein. Dement Geriatr Cogn Disord. 2011; 32(1):45-54. PMID: 21846988.
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      209. Shimada H, Suzukawa M, Ishizaki T, Kobayashi K, Kim H, Suzuki T. Relationship between subjective fall risk assessment and falls and fall-related fractures in frail elderly people. BMC Geriatr. 2011; 11:40. PMID: 21838891.
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      210. Kiyohara C, Miyake Y, Koyanagi M, Fujimoto T, Shirasawa S, Tanaka K, Fukushima W, Sasaki S, Tsuboi Y, Yamada T, Oeda T, Shimada H, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M. Genetic polymorphisms involved in dopaminergic neurotransmission and risk for Parkinson's disease in a Japanese population. BMC Neurol. 2011; 11:89. PMID: 21781348.
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      211. Shimada H, Ataka S, Takeuchi J, Mori H, Wada Y, Watanabe Y, Miki T. Pittsburgh compound B-negative dementia: a possibility of misdiagnosis of patients with non-alzheimer disease-type dementia as having AD. J Geriatr Psychiatry Neurol. 2011 Sep; 24(3):123-6. PMID: 21750305.
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      212. Kurata K, Nukui Y, Shimada H, Inoue Y, Yoshimura N, Horino A. [A case of melioidosis occurring after a long-term stay in Vietnam that developed pulmonary cavitation and relapsed with multiple pulmonary nodules]. Nihon Kokyuki Gakkai Zasshi. 2011 Jun; 49(6):443-8. PMID: 21735746.
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      213. Shima H, Tokuyama M, Tanizawa A, Tono C, Hamamoto K, Muramatsu H, Watanabe A, Hotta N, Ito M, Kurosawa H, Kato K, Tsurusawa M, Horibe K, Shimada H. Distinct impact of imatinib on growth at prepubertal and pubertal ages of children with chronic myeloid leukemia. J Pediatr. 2011 Oct; 159(4):676-81. PMID: 21592517.
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      214. Ishizaki T, Furuna T, Yoshida Y, Iwasa H, Shimada H, Yoshida H, Kumagai S, Suzuki T. Declines in physical performance by sex and age among nondisabled community-dwelling older Japanese during a 6-year period. J Epidemiol. 2011 May 5; 21(3):176-83. PMID: 21368451.
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      215. Yamakawa Y, Shimada H, Ataka S, Tamura A, Masaki H, Naka H, Tsutada T, Nakanishi A, Shiomi S, Watanabe Y, Miki T. Two cases of dementias with motor neuron disease evaluated by Pittsburgh compound B-positron emission tomography. Neurol Sci. 2012 Feb; 33(1):87-92. PMID: 21298310.
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      216. Inoue Y, Yoshimura N, Shimada H, Saito H, Shimizu K, Kurata K, Kobayashi A, Yamazaki K, Jin Y, Inase N. [Clinical features of reversed halo sign in cryptogenic organizing pneumonia]. Nihon Kokyuki Gakkai Zasshi. 2011 Feb; 49(2):75-80. PMID: 21400901.
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      217. Miki T, Shimada H. Fall and fracture of the elderly people. Nihon Ronen Igakkai Zasshi. 2011; 48(6):655-8. PMID: 22322035.
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      218. Shimada H, Tiedemann A, Lord SR, Suzukawa M, Makizako H, Kobayashi K, Suzuki T. Physical factors underlying the association between lower walking performance and falls in older people: a structural equation model. Arch Gerontol Geriatr. 2011 Sep-Oct; 53(2):131-4. PMID: 21145119.
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      219. Yamamoto A, Hattori T, Shimada H, Mori R, Kazato Y, Yuzawa M. Mycobacterium abscessus corneal ulcer following sutured clear corneal cataract incision. Jpn J Ophthalmol. 2010 Sep; 54(5):499-500. PMID: 21052916.
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      220. Cooper A, van Doorninck J, Ji L, Russell D, Ladanyi M, Shimada H, Krailo M, Womer RB, Hsu JH, Thomas D, Triche TJ, Sposto R, Lawlor ER. Ewing tumors that do not overexpress BMI-1 are a distinct molecular subclass with variant biology: a report from the Children's Oncology Group. Clin Cancer Res. 2011 Jan 1; 17(1):56-66. PMID: 21047978.
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      221. Randolph LM, Jackson HA, Wang J, Shimada H, Sanchez-Lara PA, Wong DA, Wong LJ, Boles RG. Fatal infantile lactic acidosis and a novel homozygous mutation in the SUCLG1 gene: a mitochondrial DNA depletion disorder. Mol Genet Metab. 2011 Feb; 102(2):149-52. PMID: 21093335.
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      222. Shimada H, Arai S, Nakashizuka H, Hattori T, Yuzawa M. Reduction of anterior chamber contamination rate after cataract surgery by intraoperative surface irrigation with 0.25% povidone-iodine. Am J Ophthalmol. 2011 Jan; 151(1):11-17.e1. PMID: 20970112.
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      223. Shimada H, Sturnieks D, Endo Y, Kimura Y, Suzuki T, Oda K, Ishii K, Ishiwata K. Relationship between whole body oxygen consumption and skeletal muscle glucose metabolism during walking in older adults: FDG PET study. Aging Clin Exp Res. 2011 Jun; 23(3):175-82. PMID: 20930500.
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      224. Baker DL, Schmidt ML, Cohn SL, Maris JM, London WB, Buxton A, Stram D, Castleberry RP, Shimada H, Sandler A, Shamberger RC, Look AT, Reynolds CP, Seeger RC, Matthay KK. Outcome after reduced chemotherapy for intermediate-risk neuroblastoma. N Engl J Med. 2010 Sep 30; 363(14):1313-23. PMID: 20879880.
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      225. Yu AL, Gilman AL, Ozkaynak MF, London WB, Kreissman SG, Chen HX, Smith M, Anderson B, Villablanca JG, Matthay KK, Shimada H, Grupp SA, Seeger R, Reynolds CP, Buxton A, Reisfeld RA, Gillies SD, Cohn SL, Maris JM, Sondel PM. Anti-GD2 antibody with GM-CSF, interleukin-2, and isotretinoin for neuroblastoma. N Engl J Med. 2010 Sep 30; 363(14):1324-34. PMID: 20879881.
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      226. Kim J, Wu Q, Zhang Y, Wiens KM, Huang Y, Rubin N, Shimada H, Handin RI, Chao MY, Tuan TL, Starnes VA, Lien CL. PDGF signaling is required for epicardial function and blood vessel formation in regenerating zebrafish hearts. Proc Natl Acad Sci U S A. 2010 Oct 5; 107(40):17206-10. PMID: 20858732.
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      227. Shimada H, Hirose T, Yamamoto A, Nakashizuka H, Hattori T, Yuzawa M. Depiction of the vitreous pocket by optical coherence tomography. Int Ophthalmol. 2011 Feb; 31(1):51-3. PMID: 20857172.
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      228. Shimada H, Nakashizuka H, Hattori T, Mori R, Mizutani Y, Yuzawa M. Effect of operative field irrigation on intraoperative bacterial contamination and postoperative endophthalmitis rates in 25-gauge vitrectomy. Retina. 2010 Sep; 30(8):1242-9. PMID: 20224470.
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      229. Salmi D, Patel C, Imashuku S, Shimada H, Satake N. Neuroblastoma of unknown primary site with periorbital bone metastasis in a child. Pediatr Blood Cancer. 2010 Aug; 55(2):361-3. PMID: 20582979.
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      230. Harada K, Shimada H, Sawyer P, Asakawa Y, Nihei K, Kaneya S, Furuna T, Ishizaki T, Yasumura S. [Life-space of community-dwelling older adults using preventive health care services in Japan and the validity of composite scoring methods for assessment]. Nihon Koshu Eisei Zasshi. 2010 Jul; 57(7):526-37. PMID: 20845714.
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      231. Shima H, Miharu M, Osumi T, Takahashi T, Shimada H. Differences in voriconazole trough plasma concentrations per oral dosages between children younger and older than 3 years of age. Pediatr Blood Cancer. 2010 Jul 1; 54(7):1050-2. PMID: 20146339.
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      232. Wiens KM, Lee HL, Shimada H, Metcalf AE, Chao MY, Lien CL. Platelet-derived growth factor receptor beta is critical for zebrafish intersegmental vessel formation. PLoS One. 2010; 5(6):e11324. PMID: 20593033.
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      233. Hosaka K, Shimada H, Chiba H, Katsuki H, Teranishi Y, Ohtsuki Y, Ohmori K. Ultrafast Fourier transform with a femtosecond-laser-driven molecule. Phys Rev Lett. 2010 May 7; 104(18):180501. PMID: 20482157.
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      234. Hattori T, Shimada H, Nakashizuka H, Mizutani Y, Mori R, Yuzawa M. Dose of intravitreal bevacizumab (Avastin) used as preoperative adjunct therapy for proliferative diabetic retinopathy. Retina. 2010 May; 30(5):761-4. PMID: 20453802.
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      235. Kazato Y, Shimada H, Nakashizuka H, Hattori T, Yuzawa M, Kinukawa N. Immunohistochemical findings of a Bruch's membrane defect and active choroidal neovascularization in angioid streaks. Jpn J Ophthalmol. 2010 Mar; 54(2):172-4. PMID: 20401572.
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      236. Tomiyama T, Matsuyama S, Iso H, Umeda T, Takuma H, Ohnishi K, Ishibashi K, Teraoka R, Sakama N, Yamashita T, Nishitsuji K, Ito K, Shimada H, Lambert MP, Klein WL, Mori H. A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo. J Neurosci. 2010 Apr 7; 30(14):4845-56. PMID: 20371804.
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      237. Hattori T, Shimada H, Nakashizuka H, Mori R, Mizutani Y, Yuzawa M. A new infusion sustainer that stabilizes perfusion during sutureless 25-gauge vitrectomy. Int Ophthalmol. 2010 Dec; 30(6):735-8. PMID: 20361231.
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      238. van Doorninck JA, Ji L, Schaub B, Shimada H, Wing MR, Krailo MD, Lessnick SL, Marina N, Triche TJ, Sposto R, Womer RB, Lawlor ER. Current treatment protocols have eliminated the prognostic advantage of type 1 fusions in Ewing sarcoma: a report from the Children's Oncology Group. J Clin Oncol. 2010 Apr 20; 28(12):1989-94. PMID: 20308669.
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      239. Takami M, Shimada H. [Effects of SERMs on bone health. SERM and metabolic markers of bone]. Clin Calcium. 2010 Mar; 20(3):365-71. PMID: 20190366.
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      240. Shimada H, Sawyer P, Harada K, Kaneya S, Nihei K, Asakawa Y, Yoshii C, Hagiwara A, Furuna T, Ishizaki T. Predictive validity of the classification schema for functional mobility tests in instrumental activities of daily living decline among older adults. Arch Phys Med Rehabil. 2010 Feb; 91(2):241-6. PMID: 20159128.
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      241. Shima H, Takahashi T, Shimada H. Protein-losing enteropathy caused by gastrointestinal tract-involved Langerhans cell histiocytosis. Pediatrics. 2010 Feb; 125(2):e426-32. PMID: 20083519.
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      242. Makizako H, Furuna T, Shimada H, Ihira H, Kimura M, Uchiyama E, Oddsson LI. Association between a history of falls and the ability to multi-task in community-dwelling older people. Aging Clin Exp Res. 2010 Oct-Dec; 22(5-6):427-32. PMID: 20065627.
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      243. Villemagne VL, Ataka S, Mizuno T, Brooks WS, Wada Y, Kondo M, Jones G, Watanabe Y, Mulligan R, Nakagawa M, Miki T, Shimada H, O'Keefe GJ, Masters CL, Mori H, Rowe CC. High striatal amyloid beta-peptide deposition across different autosomal Alzheimer disease mutation types. Arch Neurol. 2009 Dec; 66(12):1537-44. PMID: 20008660.
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      244. Shimada H, Hirata T, Kimura Y, Naka T, Kikuchi K, Oda K, Ishii K, Ishiwata K, Suzuki T. Effects of a robotic walking exercise on walking performance in community-dwelling elderly adults. Geriatr Gerontol Int. 2009 Dec; 9(4):372-81. PMID: 20002757.
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      245. Shimada H, Nakashizuka H, Hattori T, Mori R, Mizutani Y, Yuzawa M. Three-dimensional depiction of the vitreous pocket using triamcinolone acetonide. Eur J Ophthalmol. 2009 Nov-Dec; 19(6):1102-5. PMID: 19882554.
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      246. Shimada H, Miki T, Tamura A, Ataka S, Emoto M, Nishizawa Y. Neuropsychological status of elderly patients with diabetes mellitus. Diabetes Res Clin Pract. 2010 Feb; 87(2):224-7. PMID: 19875189.
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      247. Shimada H, Tiedemann A, Lord SR, Suzuki T. The effect of enhanced supervision on fall rates in residential aged care. Am J Phys Med Rehabil. 2009 Oct; 88(10):823-8. PMID: 21119315.
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      248. Okamatsu C, London WB, Naranjo A, Hogarty MD, Gastier-Foster JM, Look AT, LaQuaglia M, Maris JM, Cohn SL, Matthay KK, Seeger RC, Saji T, Shimada H. Clinicopathological characteristics of ganglioneuroma and ganglioneuroblastoma: a report from the CCG and COG. Pediatr Blood Cancer. 2009 Oct; 53(4):563-9. PMID: 19530234.
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      249. Muramatsu H, Kojima S, Yoshimi A, Atsuta Y, Kato K, Nagatoshi Y, Inoue M, Koike K, Kawase T, Ito M, Kurosawa H, Tanizawa A, Tono C, Hamamoto K, Hotta N, Watanabe A, Morishima Y, Kawa K, Shimada H. Outcome of 125 children with chronic myelogenous leukemia who received transplants from unrelated donors: the Japan Marrow Donor Program. Biol Blood Marrow Transplant. 2010 Feb; 16(2):231-8. PMID: 19800016.
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      250. Shimada H, Suzukawa M, Tiedemann A, Kobayashi K, Yoshida H, Suzuki T. Which neuromuscular or cognitive test is the optimal screening tool to predict falls in frail community-dwelling older people? Gerontology. 2009; 55(5):532-8. PMID: 19776609.
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      251. Shimada H, Hattori T, Nakashizuka H, Mori R, Mizutani Y, Yuzawa M. Highly viscous fluid in macular holes. Int Ophthalmol. 2010 Jun; 30(3):319-21. PMID: 19714297.
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      252. Shima H, Inokuchi M, Shimada H. A case of multisystem Langerhans cell histiocytosis with primary hypothyroidism followed by type 1 diabetes mellitus. Pediatr Blood Cancer. 2009 Aug; 53(2):232-4. PMID: 19367615.
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      253. Suzukawa M, Shimada H, Makizako H, Watanabe S, Suzuki T. [Incidence of falls and fractures in disabled elderly people utilizing long-term care insurance]. Nihon Ronen Igakkai Zasshi. 2009 Jul; 46(4):334-40. PMID: 19713666.
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      254. Makizako H, Abe T, Shimada H, Ohnuma T, Furuna T, Nakamura Y. Combined effect of factors associated with burdens on primary caregiver. Geriatr Gerontol Int. 2009 Jun; 9(2):183-9. PMID: 19740362.
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      255. Shimada H, Nakashizuka H, Hattori T, Mori R, Mizutani Y, Yuzawa M. Double staining with brilliant blue G and double peeling for epiretinal membranes. Ophthalmology. 2009 Jul; 116(7):1370-6. PMID: 19427701.
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      256. Shimada H, Ishizaki T, Kato M, Morimoto A, Tamate A, Uchiyama Y, Yasumura S. How often and how far do frail elderly people need to go outdoors to maintain functional capacity? Arch Gerontol Geriatr. 2010 Mar-Apr; 50(2):140-6. PMID: 19356806.
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      257. Mukohara T, Shimada H, Ogasawara N, Wanikawa R, Shimomura M, Nakatsura T, Ishii G, Park JO, Jänne PA, Saijo N, Minami H. Sensitivity of breast cancer cell lines to the novel insulin-like growth factor-1 receptor (IGF-1R) inhibitor NVP-AEW541 is dependent on the level of IRS-1 expression. Cancer Lett. 2009 Sep 8; 282(1):14-24. PMID: 19345478.
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      258. Hori S, Shimada H, Hattori T, Nakashizuka H, Mizutani Y, Yuzawa M. Early onset of rhegmatogenous retinal detachment after LASIK with femtosecond laser. Jpn J Ophthalmol. 2009 Jan; 53(1):75-6. PMID: 19184322.
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      259. Matthay KK, Reynolds CP, Seeger RC, Shimada H, Adkins ES, Haas-Kogan D, Gerbing RB, London WB, Villablanca JG. Long-term results for children with high-risk neuroblastoma treated on a randomized trial of myeloablative therapy followed by 13-cis-retinoic acid: a children's oncology group study. J Clin Oncol. 2009 Mar 1; 27(7):1007-13. PMID: 19171716.
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      260. Davicioni E, Anderson MJ, Finckenstein FG, Lynch JC, Qualman SJ, Shimada H, Schofield DE, Buckley JD, Meyer WH, Sorensen PH, Triche TJ. Molecular classification of rhabdomyosarcoma--genotypic and phenotypic determinants of diagnosis: a report from the Children's Oncology Group. Am J Pathol. 2009 Feb; 174(2):550-64. PMID: 19147825.
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      261. Ara T, Song L, Shimada H, Keshelava N, Russell HV, Metelitsa LS, Groshen SG, Seeger RC, DeClerck YA. Interleukin-6 in the bone marrow microenvironment promotes the growth and survival of neuroblastoma cells. Cancer Res. 2009 Jan 1; 69(1):329-37. PMID: 19118018.
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      262. Sertel O, Catalyurek UV, Shimada H, Gurcan MN. Computer-aided prognosis of neuroblastoma: detection of mitosis and karyorrhexis cells in digitized histological images. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:1433-6. PMID: 19963746.
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      263. Shimada H, Akaza E, Yuzawa M, Kawashima M. Concentration gradient of vascular endothelial growth factor in the vitreous of eyes with diabetic macular edema. Invest Ophthalmol Vis Sci. 2009 Jun; 50(6):2953-5. PMID: 19060271.
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      264. Shimada H, Nakashizuka H, Hattori T, Mori R, Mizutani Y, Yuzawa M. Incidence of endophthalmitis after 20- and 25-gauge vitrectomy causes and prevention. Ophthalmology. 2008 Dec; 115(12):2215-20. PMID: 18930557.
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      265. Shimada H, Yuzawa M, Hirose T, Nakashizuka H, Hattori T, Kazato Y. Pathological findings of multifocal choroiditis with panuveitis and punctate inner choroidopathy. Jpn J Ophthalmol. 2008 Jul-Aug; 52(4):282-8. PMID: 18773266.
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      266. Ren YX, Finckenstein FG, Abdueva DA, Shahbazian V, Chung B, Weinberg KI, Triche TJ, Shimada H, Anderson MJ. Mouse mesenchymal stem cells expressing PAX-FKHR form alveolar rhabdomyosarcomas by cooperating with secondary mutations. Cancer Res. 2008 Aug 15; 68(16):6587-97. PMID: 18701482.
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      267. Douglas D, Hsu JH, Hung L, Cooper A, Abdueva D, van Doorninck J, Peng G, Shimada H, Triche TJ, Lawlor ER. BMI-1 promotes ewing sarcoma tumorigenicity independent of CDKN2A repression. Cancer Res. 2008 Aug 15; 68(16):6507-15. PMID: 18701473.
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      268. Shimada H, Matsuzawa H. Theoretical study of stable structures and photoelectron spectra of mass-selected Al12Cs-, Al11Cs2-, and Al10Cs3- clusters. J Chem Phys. 2008 Aug 7; 129(5):054313. PMID: 18698906.
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      269. Suzuki T, Kwon J, Kim H, Shimada H, Yoshida Y, Iwasa H, Yoshida H. Low serum 25-hydroxyvitamin D levels associated with falls among Japanese community-dwelling elderly. J Bone Miner Res. 2008 Aug; 23(8):1309-17. PMID: 18410227.
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      270. Shimada H, Arai S, Kawamata T, Nakashizuka H, Hattori T, Yuzawa M. Frequency, source, and prevention of cotton fibers in the anterior chamber during cataract surgery. J Cataract Refract Surg. 2008 Aug; 34(8):1389-92. PMID: 18655993.
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      271. Kim H, Suzuki T, Yoshida H, Yoshida Y, Shimada H. [Prevalence of geriatric syndrome and risk factors associated with obesity in community-dwelling elderly women]. Nihon Ronen Igakkai Zasshi. 2008 Jul; 45(4):414-20. PMID: 18753717.
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      272. Nakashizuka H, Mitsumata M, Okisaka S, Shimada H, Kawamura A, Mori R, Yuzawa M. Clinicopathologic findings in polypoidal choroidal vasculopathy. Invest Ophthalmol Vis Sci. 2008 Nov; 49(11):4729-37. PMID: 18586873.
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      273. Singamsetty VK, Wang Y, Shimada H, Prasadarao NV. Outer membrane protein A expression in Enterobacter sakazakii is required to induce microtubule condensation in human brain microvascular endothelial cells for invasion. Microb Pathog. 2008 Sep; 45(3):181-91. PMID: 18606523.
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      274. Kong J, Sertel O, Boyer KL, Saltz JH, Gurcan MN, Shimada H. Computer-assisted grading of neuroblastic differentiation. Arch Pathol Lab Med. 2008 Jun; 132(6):903-4; author reply 904. PMID: 18517267.
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      275. Tiedemann A, Shimada H, Sherrington C, Murray S, Lord S. The comparative ability of eight functional mobility tests for predicting falls in community-dwelling older people. Age Ageing. 2008 Jul; 37(4):430-5. PMID: 18487264.
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      276. Fukaya Y, Shimada H, Wang LC, Zandi E, DeClerck YA. Identification of galectin-3-binding protein as a factor secreted by tumor cells that stimulates interleukin-6 expression in the bone marrow stroma. J Biol Chem. 2008 Jul 4; 283(27):18573-81. PMID: 18450743.
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      277. Shimasaki N, Mori T, Torii C, Sato R, Shimada H, Tanigawara Y, Kosaki K, Takahashi T. Influence of MTHFR and RFC1 polymorphisms on toxicities during maintenance chemotherapy for childhood acute lymphoblastic leukemia or lymphoma. J Pediatr Hematol Oncol. 2008 May; 30(5):347-52. PMID: 18458567.
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      278. Shimada H, Nakashizuka H, Hattori T, Mori R, Mizutani Y, Yuzawa M. Bimanual anterior vitrectomy using a 25-gauge high-speed cutter to manage vitreous loss during phacoemulsification. Int Ophthalmol. 2009 Aug; 29(4):253-5. PMID: 18338105.
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      279. Tomiyama T, Nagata T, Shimada H, Teraoka R, Fukushima A, Kanemitsu H, Takuma H, Kuwano R, Imagawa M, Ataka S, Wada Y, Yoshioka E, Nishizaki T, Watanabe Y, Mori H. A new amyloid beta variant favoring oligomerization in Alzheimer's-type dementia. Ann Neurol. 2008 Mar; 63(3):377-87. PMID: 18300294.
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      280. Kitamura K, Nakayama K, Kosaka S, Yamada E, Shimada H, Miki T, Inoue Y. Diffusion tensor imaging of the cortico-ponto-cerebellar pathway in patients with adult-onset ataxic neurodegenerative disease. Neuroradiology. 2008 Apr; 50(4):285-92. PMID: 18172629.
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      281. Makizako H, Abe T, Abe K, Kobayashi S, Koguchi R, Onuma T, Shimada H, Nakamura Y. [Factors burdening the caregiving relatives of community-dwelling disable Japanese people]. Nihon Ronen Igakkai Zasshi. 2008 Jan; 45(1):59-67. PMID: 18332574.
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      282. Tornóczky T, Semjén D, Shimada H, Ambros IM. Pathology of peripheral neuroblastic tumors: significance of prominent nucleoli in undifferentiated/poorly differentiated neuroblastoma. Pathol Oncol Res. 2007; 13(4):269-75. PMID: 18158560.
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      283. Hunter CJ, Shimada H, Asch M. An unusual case of neuroblastoma with angiomatoid features. J Pediatr Surg. 2007 Dec; 42(12):e11-3. PMID: 18082683.
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      284. Shimada H, Nakashizuka H, Hattori T, Mori R, Mizutani Y. Transient increase in macular edema following vitrectomy for retinal branch vein occlusion. Int Ophthalmol. 2009 Apr; 29(2):95-8. PMID: 18008053.
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      285. Shimada H, Kimura Y, Suzuki T, Hirata T, Sugiura M, Endo Y, Yasuhara K, Shimada K, Kikuchi K, Hashimoto M, Ishikawa M, Oda K, Ishii K, Ishiwata K. The use of positron emission tomography and [18F]fluorodeoxyglucose for functional imaging of muscular activity during exercise with a stride assistance system. IEEE Trans Neural Syst Rehabil Eng. 2007 Sep; 15(3):442-8. PMID: 17894277.
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      286. Shimada H, Lord SR, Yoshida H, Kim H, Suzuki T. Predictors of cessation of regular leisure-time physical activity in community-dwelling elderly people. Gerontology. 2007; 53(5):293-7. PMID: 17536206.
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      287. Sano H, Gonzalez-Gomez I, Wu SQ, Armenian SH, Jubran RF, Shimada H. A case of composite neuroblastoma composed of histologically and biologically distinct clones. Pediatr Dev Pathol. 2007 May-Jun; 10(3):229-32. PMID: 17535087.
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      288. Kang HG, Jenabi JM, Zhang J, Keshelava N, Shimada H, May WA, Ng T, Reynolds CP, Triche TJ, Sorensen PH. E-cadherin cell-cell adhesion in ewing tumor cells mediates suppression of anoikis through activation of the ErbB4 tyrosine kinase. Cancer Res. 2007 Apr 1; 67(7):3094-105. PMID: 17409416.
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      289. Akaza E, Fujita K, Shimada H, Yuzawa M. [Sighting dominance in patients with macular disease]. Nihon Ganka Gakkai Zasshi. 2007 Apr; 111(4):322-5. PMID: 17461037.
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      290. Shimada H, Kawamura A, Mori R, Yuzawa M. Clinicopathological findings of retinal angiomatous proliferation. Graefes Arch Clin Exp Ophthalmol. 2007 Feb; 245(2):295-300. PMID: 16738855.
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      291. Wood JC, Otto-Duessel M, Gonzalez I, Aguilar MI, Shimada H, Nick H, Nelson M, Moats R. Deferasirox and deferiprone remove cardiac iron in the iron-overloaded gerbil. Transl Res. 2006 Nov; 148(5):272-80. PMID: 17145573.
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      292. Shimada H, Nakashizuka H, Mori R, Mizutani Y, Hattori T. 25-gauge scleral tunnel transconjunctival vitrectomy. Am J Ophthalmol. 2006 Nov; 142(5):871-3. PMID: 17056376.
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      293. Moreau LA, McGrady P, London WB, Shimada H, Cohn SL, Maris JM, Diller L, Look AT, George RE. Does MYCN amplification manifested as homogeneously staining regions at diagnosis predict a worse outcome in children with neuroblastoma? A Children's Oncology Group study. Clin Cancer Res. 2006 Oct 1; 12(19):5693-7. PMID: 17020972.
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      294. Asgharzadeh S, Pique-Regi R, Sposto R, Wang H, Yang Y, Shimada H, Matthay K, Buckley J, Ortega A, Seeger RC. Prognostic significance of gene expression profiles of metastatic neuroblastomas lacking MYCN gene amplification. J Natl Cancer Inst. 2006 Sep 6; 98(17):1193-203. PMID: 16954472.
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      295. Shimada H, Nakashizuka H, Hattori T, Mori R, Mizutani Y. Thermal injury caused by chandelier fiber probe. Am J Ophthalmol. 2007 Jan; 143(1):167-9. PMID: 17188060.
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      296. Uchino M, Ogawa Y, Kawai M, Shimada H, Kameyama K, Okamoto S, Dogru M, Tsubota K. Ocular complications in a child with acute graft-versus-host disease following cord blood stem cell transplantation: therapeutic challenges. Acta Ophthalmol Scand. 2006 Aug; 84(4):545-8. PMID: 16879579.
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      297. Nakata M, Yuzawa M, Kawamura A, Shimada H. Combining surgical ablation of retinal inflow and outflow vessels with photodynamic therapy for retinal angiomatous proliferation. Am J Ophthalmol. 2006 May; 141(5):968-70. PMID: 16678525.
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      298. Sano H, Bonadio J, Gerbing RB, London WB, Matthay KK, Lukens JN, Shimada H. International neuroblastoma pathology classification adds independent prognostic information beyond the prognostic contribution of age. Eur J Cancer. 2006 May; 42(8):1113-9. PMID: 16624549.
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      299. Shimasaki N, Mori T, Samejima H, Sato R, Shimada H, Yahagi N, Torii C, Yoshihara H, Tanigawara Y, Takahashi T, Kosaki K. Effects of methylenetetrahydrofolate reductase and reduced folate carrier 1 polymorphisms on high-dose methotrexate-induced toxicities in children with acute lymphoblastic leukemia or lymphoma. J Pediatr Hematol Oncol. 2006 Feb; 28(2):64-8. PMID: 16462575.
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      300. Narumi S, Shimada H, Shimasaki N, Takahashi T, Hasegawa T, Mori T. Growth-chart-based qualitative evaluation of height growth after hematopoietic stem cell transplantation. Pediatr Transplant. 2006 Feb; 10(1):26-31. PMID: 16499583.
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      301. Mizutani Y, Nakayama T, Asai S, Shimada H, Yuzawa M. ABCC6 Mutation in Patients with Angioid Streaks. Int J Biomed Sci. 2006 Feb; 2(1):7-12. PMID: 23674961.
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      302. Gurcan MN, Pan T, Shimada H, Saltz J. Image analysis for neuroblastoma classification: segmentation of cell nuclei. Conf Proc IEEE Eng Med Biol Soc. 2006; 1:4844-7. PMID: 17947119.
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      303. Attiyeh EF, London WB, Mossé YP, Wang Q, Winter C, Khazi D, McGrady PW, Seeger RC, Look AT, Shimada H, Brodeur GM, Cohn SL, Matthay KK, Maris JM. Chromosome 1p and 11q deletions and outcome in neuroblastoma. N Engl J Med. 2005 Nov 24; 353(21):2243-53. PMID: 16306521.
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      304. Nakamae H, Himuro K, Hagihara K, Terada Y, Sakamoto E, Takeoka Y, Nakane T, Nakamae M, Ohta K, Yamane T, Shimada H, Miki T, Hino M. [Chronic GVHD with polymyositis after non-myeloablative stem cell transplantation]. Rinsho Ketsueki. 2005 Nov; 46(11):1213-7. PMID: 16440806.
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      305. Sohara Y, Shimada H, DeClerck YA. Mechanisms of bone invasion and metastasis in human neuroblastoma. Cancer Lett. 2005 Oct 18; 228(1-2):203-9. PMID: 15975706.
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      306. Shimada H, Nakashizuka H, Mori R, Mizutani Y. Expanded indications for 25-gauge transconjunctival vitrectomy. Jpn J Ophthalmol. 2005 Sep-Oct; 49(5):397-401. PMID: 16187041.
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      307. Uei B, Lee Z, Shimada H, Yuzawa M. [Preoperative factors for postoperative resolution of metamorphopsia in idiopathic macular hole surgery]. Nihon Ganka Gakkai Zasshi. 2005 Sep; 109(9):591-5. PMID: 16218437.
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      308. Schmidt ML, Lal A, Seeger RC, Maris JM, Shimada H, O'Leary M, Gerbing RB, Matthay KK. Favorable prognosis for patients 12 to 18 months of age with stage 4 nonamplified MYCN neuroblastoma: a Children's Cancer Group Study. J Clin Oncol. 2005 Sep 20; 23(27):6474-80. PMID: 16116154.
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      309. Shimada H. In situ neuroblastoma: an important concept related to the natural history of neural crest tumors. Pediatr Dev Pathol. 2005 May-Jun; 8(3):305-6. PMID: 16010489.
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      310. Shimada H, Fujita K, Matsumoto Y, Mori R, Yuzawa M. Surgical excision of type 1 + 2 choroidal neovascularization in age-related macular degeneration. Jpn J Ophthalmol. 2005 Jul-Aug; 49(4):324-6. PMID: 16075336.
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      311. Shimada H, Fujita K, Matsumoto Y, Mori R, Yuzawa M. Surgical excision of type 2 choroidal neovascularization in age-related macular degeneration. Jpn J Ophthalmol. 2005 Jul-Aug; 49(4):321-3. PMID: 16075335.
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      312. Kamura Y, Sato Y, Isomae T, Shimada H. Effects of internal limiting membrane peeling in vitrectomy on diabetic cystoid macular edema patients. Jpn J Ophthalmol. 2005 Jul-Aug; 49(4):297-300. PMID: 16075329.
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      313. Qualman SJ, Bowen J, Fitzgibbons PL, Cohn SL, Shimada H. Protocol for the examination of specimens from patients with neuroblastoma and related neuroblastic tumors. Arch Pathol Lab Med. 2005 Jul; 129(7):874-83. PMID: 15974810.
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      314. Hu-Lieskovan S, Zhang J, Wu L, Shimada H, Schofield DE, Triche TJ. EWS-FLI1 fusion protein up-regulates critical genes in neural crest development and is responsible for the observed phenotype of Ewing's family of tumors. Cancer Res. 2005 Jun 1; 65(11):4633-44. PMID: 15930281.
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      315. Shimada H, Nakashizuka H, Nakajima M, Mori R, Mizutani Y. Twenty-gauge Transconjunctival Vitrectomy. Jpn J Ophthalmol. 2005 May-Jun; 49(3):257-60. PMID: 15944835.
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      316. Kobayashi H, Carbonaro D, Pepper K, Petersen D, Ge S, Jackson H, Shimada H, Moats R, Kohn DB. Neonatal gene therapy of MPS I mice by intravenous injection of a lentiviral vector. Mol Ther. 2005 May; 11(5):776-89. PMID: 15851016.
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      317. Jodele S, Chantrain CF, Blavier L, Lutzko C, Crooks GM, Shimada H, Coussens LM, Declerck YA. The contribution of bone marrow-derived cells to the tumor vasculature in neuroblastoma is matrix metalloproteinase-9 dependent. Cancer Res. 2005 Apr 15; 65(8):3200-8. PMID: 15833851.
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      318. Miki T, Shimada H. [Evaluation of osteoporosis by markers of bone metabolism]. Nihon Naika Gakkai Zasshi. 2005 Apr 10; 94(4):675-81. PMID: 15864994.
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      319. Sohara Y, Shimada H, Minkin C, Erdreich-Epstein A, Nolta JA, DeClerck YA. Bone marrow mesenchymal stem cells provide an alternate pathway of osteoclast activation and bone destruction by cancer cells. Cancer Res. 2005 Feb 15; 65(4):1129-35. PMID: 15734993.
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      320. Erdreich-Epstein A, Tran LB, Cox OT, Huang EY, Laug WE, Shimada H, Millard M. Endothelial apoptosis induced by inhibition of integrins alphavbeta3 and alphavbeta5 involves ceramide metabolic pathways. Blood. 2005 Jun 1; 105(11):4353-61. PMID: 15705795.
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      321. Layfield LJ, Willmore-Payne C, Shimada H, Holden JA. Assessment of NMYC amplification: a comparison of FISH, quantitative PCR monoplexing and traditional blotting methods used with formalin-fixed, paraffin-embedded neuroblastomas. Anal Quant Cytol Histol. 2005 Feb; 27(1):5-14. PMID: 15794447.
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      322. Kobayashi C, Monforte-Munoz HL, Gerbing RB, Stram DO, Matthay KK, Lukens JN, Seeger RC, Shimada H. Enlarged and prominent nucleoli may be indicative of MYCN amplification: a study of neuroblastoma (Schwannian stroma-poor), undifferentiated/poorly differentiated subtype with high mitosis-karyorrhexis index. Cancer. 2005 Jan 1; 103(1):174-80. PMID: 15549714.
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      323. Shimada H, Mori R, Arai K, Kawamura A, Yuzawa M. Surgical excision of neovascularization in retinal angiomatous proliferation. Graefes Arch Clin Exp Ophthalmol. 2005 Jun; 243(6):519-24. PMID: 15965671.
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      324. McLean TW, Iskandar SS, Shimada H, Hall MC. Neuroblastoma in an adult. Urology. 2004 Dec; 64(6):1232. PMID: 15596213.
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      325. Ataka S, Tomiyama T, Takuma H, Yamashita T, Shimada H, Tsutada T, Kawabata K, Mori H, Miki T. A novel presenilin-1 mutation (Leu85Pro) in early-onset Alzheimer disease with spastic paraparesis. Arch Neurol. 2004 Nov; 61(11):1773-6. PMID: 15534188.
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      326. Shimada H, Nakagawa A, Peters J, Wang H, Wakamatsu PK, Lukens JN, Matthay KK, Siegel SE, Seeger RC. TrkA expression in peripheral neuroblastic tumors: prognostic significance and biological relevance. Cancer. 2004 Oct 15; 101(8):1873-81. PMID: 15386308.
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      327. Shimada H, Shimizu K, Mimaki S, Sakiyama T, Mori T, Shimasaki N, Yokota J, Nakachi K, Ohta T, Ohki M. First case of aplastic anemia in a Japanese child with a homozygous missense mutation in the NBS1 gene (I171V) associated with genomic instability. Hum Genet. 2004 Oct; 115(5):372-6. PMID: 15338273.
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      328. Shimada H, Obuchi S, Furuna T, Suzuki T. New intervention program for preventing falls among frail elderly people: the effects of perturbed walking exercise using a bilateral separated treadmill. Am J Phys Med Rehabil. 2004 Jul; 83(7):493-9. PMID: 15213472.
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      329. Shimada H, Suzuki T, Obuchi S, Furuna T. [Effects of introducing a risk manager for prevention of falls in a long-term care facility]. Nihon Ronen Igakkai Zasshi. 2004 Jul; 41(4):414-9. PMID: 15387286.
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      330. Sugita M, Mori T, Shimada H, Shimasaki N, Morikawa Y, Takahashi T. Colocolic intussusception associated with pneumatosis cystoides intestinalis after cord blood stem cell transplantation. J Pediatr Gastroenterol Nutr. 2004 May; 38(5):549-51. PMID: 15097449.
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      331. Nakajima M, Yuzawa M, Shimada H, Mori R. Correlation between indocyanine green angiographic findings and histopathology of polypoidal choroidal vasculopathy. Jpn J Ophthalmol. 2004 May-Jun; 48(3):249-55. PMID: 15175917.
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      332. Obuchi S, Kojima M, Shiba Y, Shimada H, Suzuki T. [A randomized controlled trial of a treadmill training with the perturbation to improve the balance performance in the community dwelling elderly subjects]. Nihon Ronen Igakkai Zasshi. 2004 May; 41(3):321-7. PMID: 15237752.
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      333. Ferrario A, Chantrain CF, von Tiehl K, Buckley S, Rucker N, Shalinsky DR, Shimada H, DeClerck YA, Gomer CJ. The matrix metalloproteinase inhibitor prinomastat enhances photodynamic therapy responsiveness in a mouse tumor model. Cancer Res. 2004 Apr 1; 64(7):2328-32. PMID: 15059880.
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      334. Chantrain CF, Shimada H, Jodele S, Groshen S, Ye W, Shalinsky DR, Werb Z, Coussens LM, DeClerck YA. Stromal matrix metalloproteinase-9 regulates the vascular architecture in neuroblastoma by promoting pericyte recruitment. Cancer Res. 2004 Mar 1; 64(5):1675-86. PMID: 14996727.
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      335. Yahagi N, Kosaki R, Ito T, Mitsuhashi T, Shimada H, Tomita M, Takahashi T, Kosaki K. Position-specific expression of Hox genes along the gastrointestinal tract. Congenit Anom (Kyoto). 2004 Mar; 44(1):18-26. PMID: 15008896.
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      336. Misawa F, Miyaji S, Fuji Y, Miyata R, Obi K, Koshiishi F, Shimada H, Fukuda M, Koizumi T. The incidence of hyperglycemia in patients treated with olanzapine. J Clin Psychiatry. 2004 Mar; 65(3):443-4. PMID: 15096088.
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      337. Nakashizuka H, Shimada H, Iwasaki Y, Matsumoto Y, Sato Y. Pars plana suture fixation for intraocular lenses dislocated into the vitreous cavity using a closed-eye cow-hitch technique. J Cataract Refract Surg. 2004 Feb; 30(2):302-6. PMID: 15030816.
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      338. Shimasaki N, Mori T, Shimada H, Sugita M, Higuchi M, Mukai M, Morio T, Okamoto S. Epstein-Barr virus-associated posttransplant lymphoproliferative disorder after a cord blood stem cell transplantation presenting with pulmonary nodules. J Pediatr Hematol Oncol. 2004 Feb; 26(2):124-7. PMID: 14767205.
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      339. Tornóczky T, Kálmán E, Kajtár PG, Nyári T, Pearson AD, Tweddle DA, Board J, Shimada H. Large cell neuroblastoma: a distinct phenotype of neuroblastoma with aggressive clinical behavior. Cancer. 2004 Jan 15; 100(2):390-7. PMID: 14716776.
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      340. Hill VT, Townsend SM, Arias RS, Jenabi JM, Gomez-Gonzalez I, Shimada H, Badger JL. TraJ-dependent Escherichia coli K1 interactions with professional phagocytes are important for early systemic dissemination of infection in the neonatal rat. Infect Immun. 2004 Jan; 72(1):478-88. PMID: 14688129.
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      341. Shimada H. [Activity of the central nervous system and calcium]. Clin Calcium. 2004 Jan; 14(1):106-9. PMID: 15576965.
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      342. Peuchmaur M, d'Amore ES, Joshi VV, Hata J, Roald B, Dehner LP, Gerbing RB, Stram DO, Lukens JN, Matthay KK, Shimada H. Revision of the International Neuroblastoma Pathology Classification: confirmation of favorable and unfavorable prognostic subsets in ganglioneuroblastoma, nodular. Cancer. 2003 Nov 15; 98(10):2274-81. PMID: 14601099.
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      343. Mikuni E, Shimada H, Mori R, Nemoto A, Yuzawa M. [Surgical removal of juxtafoveal and extrafoveal choroidal neovascularization in age-related macular degeneration]. Nihon Ganka Gakkai Zasshi. 2003 Nov; 107(11):695-701. PMID: 14661543.
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      344. Townsend SM, Pollack HA, Gonzalez-Gomez I, Shimada H, Badger JL. Citrobacter koseri brain abscess in the neonatal rat: survival and replication within human and rat macrophages. Infect Immun. 2003 Oct; 71(10):5871-80. PMID: 14500508.
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      345. Sukumaran SK, Shimada H, Prasadarao NV. Entry and intracellular replication of Escherichia coli K1 in macrophages require expression of outer membrane protein A. Infect Immun. 2003 Oct; 71(10):5951-61. PMID: 14500515.
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      346. Batra S, Perelman N, Luck LR, Shimada H, Malik P. Pediatric tumor cells express erythropoietin and a functional erythropoietin receptor that promotes angiogenesis and tumor cell survival. Lab Invest. 2003 Oct; 83(10):1477-87. PMID: 14563949.
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      347. Tanaka M, Shimada H, Haruyama M, Lee Z, Nakajima M, Yuzawa M. [Surgical removal of choroidal neovascularization in angioid streaks]. Nihon Ganka Gakkai Zasshi. 2003 Aug; 107(8):440-4. PMID: 13677296.
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      348. Shimada H, Obuchi S, Kamide N, Shiba Y, Okamoto M, Kakurai S. Relationship with dynamic balance function during standing and walking. Am J Phys Med Rehabil. 2003 Jul; 82(7):511-6. PMID: 12819538.
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      349. Sohara Y, Shimada H, Scadeng M, Pollack H, Yamada S, Ye W, Reynolds CP, DeClerck YA. Lytic bone lesions in human neuroblastoma xenograft involve osteoclast recruitment and are inhibited by bisphosphonate. Cancer Res. 2003 Jun 15; 63(12):3026-31. PMID: 12810621.
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      350. Mori T, Kiyokawa N, Shimada H, Miyauchi J, Fujimoto J. Anaplastic large cell lymphoma in Japanese children: retrospective analysis of 34 patients diagnosed at the National Research Institute for Child Health and Development. Br J Haematol. 2003 Apr; 121(1):94-6. PMID: 12670336.
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      351. Tsutada T, Ikeda H, Tsuyuguchi N, Hattori H, Shimogawara M, Shimada H, Miki T. Detecting functional asymmetries through the dipole moment of magnetoencephalography. J Neurol Sci. 2002 Jun 15; 198(1-2):51-61. PMID: 12039664.
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      352. Metelitsa LS, Gillies SD, Super M, Shimada H, Reynolds CP, Seeger RC. Antidisialoganglioside/granulocyte macrophage-colony-stimulating factor fusion protein facilitates neutrophil antibody-dependent cellular cytotoxicity and depends on FcgammaRII (CD32) and Mac-1 (CD11b/CD18) for enhanced effector cell adhesion and azurophil granule exocytosis. Blood. 2002 Jun 1; 99(11):4166-73. PMID: 12010822.
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      353. Shimada H. Correspondence re: J. Mora et al., Neuroblastic and Schwannian stromal cells of neuroblastoma are derived from a tumoral progenitor cell. Cancer Res., 61: 6892-6898, 2001. Cancer Res. 2002 May 15; 62(10):2987-8; author reply 2988-9. PMID: 12025836.
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      354. Uno K, Takita J, Yokomori K, Tanaka Y, Ohta S, Shimada H, Gilles FH, Sugita K, Abe S, Sako M, Hashizume K, Hayashi Y. Aberrations of the hSNF5/INI1 gene are restricted to malignant rhabdoid tumors or atypical teratoid/rhabdoid tumors in pediatric solid tumors. Genes Chromosomes Cancer. 2002 May; 34(1):33-41. PMID: 11921280.
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      355. Sato Y, Lee Z, Shimada H. Vitrectomy for diabetic cystoid macular edema. Jpn J Ophthalmol. 2002 May-Jun; 46(3):315-22. PMID: 12063043.
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      356. Taga T, Suzuki A, Gonzalez-Gomez I, Gilles FH, Stins M, Shimada H, Barsky L, Weinberg KI, Laug WE. alpha v-Integrin antagonist EMD 121974 induces apoptosis in brain tumor cells growing on vitronectin and tenascin. Int J Cancer. 2002 Apr 10; 98(5):690-7. PMID: 11920637.
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      357. Shimada H, Uchiyama Y, Kakurai S. [Relationship between lifestyle activities and physical functions in elderly persons utilizing care facilities]. Nihon Ronen Igakkai Zasshi. 2002 Mar; 39(2):197-203. PMID: 11974945.
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      358. Ambros IM, Hata J, Joshi VV, Roald B, Dehner LP, Tüchler H, Pötschger U, Shimada H. Morphologic features of neuroblastoma (Schwannian stroma-poor tumors) in clinically favorable and unfavorable groups. Cancer. 2002 Mar 1; 94(5):1574-83. PMID: 11920516.
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      359. Matsumoto Y, Shimada H, Kawamura A, Yuzawa M. [Preoperative factors influencing visual acuity following vitrectomy for exudative age-related macular degeneration]. Nihon Ganka Gakkai Zasshi. 2002 Jan; 106(1):16-22. PMID: 11828761.
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      360. Isomae T, Sato Y, Shimada H. Shortening the duration of prone positioning after macular hole surgery- comparison between 1-week and 1-day prone positioning. Jpn J Ophthalmol. 2002 Jan-Feb; 46(1):84-8. PMID: 11853720.
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