Henry M. Sucov, PhD

TitleProfessor of Stem Cell & Regenerative Medicine
InstitutionUniversity of Southern California
DepartmentCell and Neurobiology
AddressBCC 511 1425 San Pablo Street
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 2563
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    Other Positions
    TitleDirector, MS Program in Stem Cell Biology and Regenerative Medicine

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    Sucov Lab Website

    Henry Sucov has been recognized several times by the American Heart Association for his work in cardiovascular development. He has served on many grant review panels and committees, and is currently a member of the NIH Cardiovascular Development and Differentiation (CDD) study section. In 2007, he was a Visiting Scholar of the Japanese Society for the Promotion of Science.

    His scientific program is historically grounded in cardiovascular development, reflecting a longstanding interest is in processes that account for ventricular chamber morphogenesis, including mechanisms that support cardiomyocyte proliferation, coronary vascularization and mesenchymal progenitor cell differentiation. More recently, he has increasingly gravitated to the connection between embryonic heart development and postnatal heart biology, and in particular how the postnatal post-injury repair and regenerative response of the heart recapitulates processes that occur in normal development. His lab primarily studies these processes in mice using molecular genetic and genomic strategies.

    Collapse Research 
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    Cardiomyocyte heterogeneity and aging
    NIH/NIA R21AG050274Jul 1, 2015 - Apr 30, 2017
    Role: Principal Investigator
    TGFb and Cardiac Neural Crest Cell Fate and Function
    NIH/NHLBI R01HL078891Apr 1, 2006 - Mar 31, 2011
    Role: Principal Investigator
    Cardiomyocyte Proliferation and Ventricular Morphogenesis
    NIH/NHLBI R01HL070123Jul 1, 2002 - Jun 30, 2020
    Role: Principal Investigator
    Retinoic Acid Regulation of Erythropoiesis
    NIH/NHLBI R01HL066059Aug 15, 2001 - Jul 31, 2005
    Role: Principal Investigator
    NIH/NIDDK R21DK059192Sep 30, 2000 - Jul 31, 2003
    Role: Principal Investigator
    NIH/NHLBI R01HL057212Jul 7, 1999 - Jun 30, 2003
    Role: Principal Investigator

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    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Patterson M, Barske L, Van Handel B, Rau CD, Gan P, Sharma A, Parikh S, Denholtz M, Huang Y, Yamaguchi Y, Shen H, Allayee H, Crump JG, Force TI, Lien CL, Makita T, Lusis AJ, Kumar SR, Sucov HM. Frequency of mononuclear diploid cardiomyocytes underlies natural variation in heart regeneration. Nat Genet. 2017 Sep; 49(9):1346-1353. PMID: 28783163.
      View in: PubMed
    2. Zhang H, Pu W, Li G, Huang X, He L, Tian X, Liu Q, Zhang L, Wu SM, Sucov HM, Zhou B. Endocardium Minimally Contributes to Coronary Endothelium in the Embryonic Ventricular Free Walls. Circ Res. 2016 Jun 10; 118(12):1880-93. PMID: 27056912.
      View in: PubMed
    3. Ma M, Li P, Shen H, Estrada KD, Xu J, Kumar SR, Sucov HM. Dysregulated endocardial TGFß signaling and mesenchymal transformation result in heart outflow tract septation failure. Dev Biol. 2016 Jan 01; 409(1):272-276. PMID: 26522286.
      View in: PubMed
    4. Harrison MR, Bussmann J, Huang Y, Zhao L, Osorio A, Burns CG, Burns CE, Sucov HM, Siekmann AF, Lien CL. Chemokine-guided angiogenesis directs coronary vasculature formation in zebrafish. Dev Cell. 2015 May 26; 33(4):442-54. PMID: 26017769; PMCID: PMC4448080.
    5. Cavallero S, Shen H, Yi C, Lien CL, Kumar SR, Sucov HM. CXCL12 Signaling Is Essential for Maturation of the Ventricular Coronary Endothelial Plexus and Establishment of Functional Coronary Circulation. Dev Cell. 2015 May 26; 33(4):469-77. PMID: 26017771; PMCID: PMC4448078.
    6. Yamaguchi Y, Cavallero S, Patterson M, Shen H, Xu J, Kumar SR, Sucov HM. Adipogenesis and epicardial adipose tissue: a novel fate of the epicardium induced by mesenchymal transformation and PPAR? activation. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):2070-5. PMID: 25646471; PMCID: PMC4343131.
    7. Shen H, Cavallero S, Estrada KD, Sandovici I, Kumar SR, Makita T, Lien CL, Constancia M, Sucov HM. Extracardiac control of embryonic cardiomyocyte proliferation and ventricular wall expansion. Cardiovasc Res. 2015 Mar 01; 105(3):271-8. PMID: 25560321; PMCID: PMC4366578.
    8. Cambier L, Plate M, Sucov HM, Pashmforoush M. Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3. Development. 2014 Aug; 141(15):2959-71. PMID: 25053429; PMCID: PMC4197672.
    9. Engelhard C, Sarsfield S, Merte J, Wang Q, Li P, Beppu H, Kolodkin AL, Sucov HM, Ginty DD. MEGF8 is a modifier of BMP signaling in trigeminal sensory neurons. Elife. 2013 Sep 17; 2:e01160. PMID: 24052814; PMCID: PMC3776557.
    10. Huang Y, Harrison MR, Osorio A, Kim J, Baugh A, Duan C, Sucov HM, Lien CL. Igf Signaling is Required for Cardiomyocyte Proliferation during Zebrafish Heart Development and Regeneration. PLoS One. 2013; 8(6):e67266. PMID: 23840646; PMCID: PMC3694143.
    11. Zhou J, Pashmforoush M, Sucov HM. Endothelial neuropilin disruption in mice causes DiGeorge syndrome-like malformations via mechanisms distinct to those caused by loss of Tbx1. PLoS One. 2012; 7(3):e32429. PMID: 22396765; PMCID: PMC3292556.
    12. Li P, Pashmforoush M, Sucov HM. Mesodermal retinoic acid signaling regulates endothelial cell coalescence in caudal pharyngeal arch artery vasculogenesis. Dev Biol. 2012 Jan 01; 361(1):116-24. PMID: 22040871; PMCID: PMC3235035.
    13. Li P, Cavallero S, Gu Y, Chen TH, Hughes J, Hassan AB, Brüning JC, Pashmforoush M, Sucov HM. IGF signaling directs ventricular cardiomyocyte proliferation during embryonic heart development. Development. 2011 May; 138(9):1795-805. PMID: 21429986; PMCID: PMC3074453.
    14. Snead ML, Zhu DH, Lei Y, Luo W, Bringas PO, Sucov HM, Rauth RJ, Paine ML, White SN. A simplified genetic design for mammalian enamel. Biomaterials. 2011 Apr; 32(12):3151-7. PMID: 21295848; PMCID: PMC3045652.
    15. Brade T, Kumar S, Cunningham TJ, Chatzi C, Zhao X, Cavallero S, Li P, Sucov HM, Ruiz-Lozano P, Duester G. Retinoic acid stimulates myocardial expansion by induction of hepatic erythropoietin which activates epicardial Igf2. Development. 2011 Jan; 138(1):139-48. PMID: 21138976; PMCID: PMC2998168.
    16. Li P, Pashmforoush M, Sucov HM. Retinoic acid regulates differentiation of the secondary heart field and TGFbeta-mediated outflow tract septation. Dev Cell. 2010 Mar 16; 18(3):480-5. PMID: 20230754; PMCID: PMC2841063.
    17. Nolting J, Daniel C, Reuter S, Stuelten C, Li P, Sucov H, Kim BG, Letterio JJ, Kretschmer K, Kim HJ, von Boehmer H. Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines. J Exp Med. 2009 Sep 28; 206(10):2131-9. PMID: 19737861; PMCID: PMC2757891.
    18. Sucov HM, Gu Y, Thomas S, Li P, Pashmforoush M. Epicardial control of myocardial proliferation and morphogenesis. Pediatr Cardiol. 2009 Jul; 30(5):617-25. PMID: 19277768.
      View in: PubMed
    19. Asahina K, Tsai SY, Li P, Ishii M, Maxson RE, Sucov HM, Tsukamoto H. Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development. Hepatology. 2009 Mar; 49(3):998-1011. PMID: 19085956; PMCID: PMC2673117.
    20. Choudhary B, Zhou J, Li P, Thomas S, Kaartinen V, Sucov HM. Absence of TGFbeta signaling in embryonic vascular smooth muscle leads to reduced lysyl oxidase expression, impaired elastogenesis, and aneurysm. Genesis. 2009 Feb; 47(2):115-21. PMID: 19165826.
      View in: PubMed
    21. Chen YH, Ishii M, Sucov HM, Maxson RE. Msx1 and Msx2 are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium. BMC Dev Biol. 2008 Jul 30; 8:75. PMID: 18667074; PMCID: PMC2518925.
    22. Makita T, Sucov HM, Gariepy CE, Yanagisawa M, Ginty DD. Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons. Nature. 2008 Apr 10; 452(7188):759-63. PMID: 18401410; PMCID: PMC2713667.
    23. Kang J, Gu Y, Li P, Johnson BL, Sucov HM, Thomas PS. PDGF-A as an epicardial mitogen during heart development. Dev Dyn. 2008 Mar; 237(3):692-701. PMID: 18297729.
      View in: PubMed
    24. Kameda Y, Nishimaki T, Chisaka O, Iseki S, Sucov HM. Expression of the epithelial marker E-cadherin by thyroid C cells and their precursors during murine development. J Histochem Cytochem. 2007 Oct; 55(10):1075-88. PMID: 17595340.
      View in: PubMed
    25. Chen YH, Ishii M, Sun J, Sucov HM, Maxson RE. Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract. Dev Biol. 2007 Aug 15; 308(2):421-37. PMID: 17601530.
      View in: PubMed
    26. Wang J, Nagy A, Larsson J, Dudas M, Sucov HM, Kaartinen V. Defective ALK5 signaling in the neural crest leads to increased postmigratory neural crest cell apoptosis and severe outflow tract defects. BMC Dev Biol. 2006 Nov 01; 6:51. PMID: 17078885; PMCID: PMC1635039.
    27. Choudhary B, Ito Y, Makita T, Sasaki T, Chai Y, Sucov HM. Cardiovascular malformations with normal smooth muscle differentiation in neural crest-specific type II TGFbeta receptor (Tgfbr2) mutant mice. Dev Biol. 2006 Jan 15; 289(2):420-9. PMID: 16332365.
      View in: PubMed
    28. Ishii M, Han J, Yen HY, Sucov HM, Chai Y, Maxson RE. Combined deficiencies of Msx1 and Msx2 cause impaired patterning and survival of the cranial neural crest. Development. 2005 Nov; 132(22):4937-50. PMID: 16221730.
      View in: PubMed
    29. Makita T, Duncan SA, Sucov HM. Retinoic acid, hypoxia, and GATA factors cooperatively control the onset of fetal liver erythropoietin expression and erythropoietic differentiation. Dev Biol. 2005 Apr 01; 280(1):59-72. PMID: 15766748.
      View in: PubMed
    30. Kang JO, Sucov HM. Convergent proliferative response and divergent morphogenic pathways induced by epicardial and endocardial signaling in fetal heart development. Mech Dev. 2005 Jan; 122(1):57-65. PMID: 15582777.
      View in: PubMed
    31. Kertesz N, Wu J, Chen TH, Sucov HM, Wu H. The role of erythropoietin in regulating angiogenesis. Dev Biol. 2004 Dec 01; 276(1):101-10. PMID: 15531367.
      View in: PubMed
    32. Ishii M, Merrill AE, Chan YS, Gitelman I, Rice DP, Sucov HM, Maxson RE. Msx2 and Twist cooperatively control the development of the neural crest-derived skeletogenic mesenchyme of the murine skull vault. Development. 2003 Dec; 130(24):6131-42. PMID: 14597577.
      View in: PubMed
    33. Han J, Ito Y, Yeo JY, Sucov HM, Maas R, Chai Y. Cranial neural crest-derived mesenchymal proliferation is regulated by Msx1-mediated p19(INK4d) expression during odontogenesis. Dev Biol. 2003 Sep 01; 261(1):183-96. PMID: 12941628.
      View in: PubMed
    34. Chen T, Chang TC, Kang JO, Choudhary B, Makita T, Tran CM, Burch JB, Eid H, Sucov HM. Epicardial induction of fetal cardiomyocyte proliferation via a retinoic acid-inducible trophic factor. Dev Biol. 2002 Oct 01; 250(1):198-207. PMID: 12297106.
      View in: PubMed
    35. Jiang X, Choudhary B, Merki E, Chien KR, Maxson RE, Sucov HM. Normal fate and altered function of the cardiac neural crest cell lineage in retinoic acid receptor mutant embryos. Mech Dev. 2002 Sep; 117(1-2):115-22. PMID: 12204252.
      View in: PubMed
    36. Huang J, Powell WC, Khodavirdi AC, Wu J, Makita T, Cardiff RD, Cohen MB, Sucov HM, Roy-Burman P. Prostatic intraepithelial neoplasia in mice with conditional disruption of the retinoid X receptor alpha allele in the prostate epithelium. Cancer Res. 2002 Aug 15; 62(16):4812-9. PMID: 12183441.
      View in: PubMed
    37. Jiang X, Iseki S, Maxson RE, Sucov HM, Morriss-Kay GM. Tissue origins and interactions in the mammalian skull vault. Dev Biol. 2002 Jan 01; 241(1):106-16. PMID: 11784098.
      View in: PubMed
    38. Brewer S, Jiang X, Donaldson S, Williams T, Sucov HM. Requirement for AP-2alpha in cardiac outflow tract morphogenesis. Mech Dev. 2002 Jan; 110(1-2):139-49. PMID: 11744375.
      View in: PubMed
    39. Kwang SJ, Brugger SM, Lazik A, Merrill AE, Wu LY, Liu YH, Ishii M, Sangiorgi FO, Rauchman M, Sucov HM, Maas RL, Maxson RE. Msx2 is an immediate downstream effector of Pax3 in the development of the murine cardiac neural crest. Development. 2002 Jan; 129(2):527-38. PMID: 11807043.
      View in: PubMed
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