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Henry Forman

Title(s)Research Professor Emeritus of Gerontology
Phone+ 1 818 288 1573
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    Collapse Research 
    Collapse Research Activities and Funding
    Human models of the particulate-induced inflammatory/antioxidant axis in aging
    NIH/NIEHS R01ES023864Feb 9, 2015 - Nov 30, 2019
    Role: Principal Investigator
    Human models of the particulate-induced inflammatory/antioxidant axis in aging
    NIH/NIEHS R56ES023864Jun 1, 2014 - May 31, 2015
    Role: Principal Investigator
    Oxidative activation of Src in smoke-induced epithelial mesenchymal transition
    NIH/NIEHS R21ES020942Sep 1, 2012 - Aug 31, 2014
    Role: Principal Investigator
    2006 Oxygen Radicals in Biology Gordon Conferences
    NIH/NHLBI R13HL083487Aug 10, 2005 - Jul 31, 2006
    Role: Principal Investigator
    Hydroxynonenal induces glutathione synthesis through JNK
    NIH/NIEHS R56ES005511Apr 15, 1996 - Mar 31, 2007
    Role: Principal Investigator
    NO2 INDUCED PEROXIDATION PRODUCTS AND AIRWAY REACTIVITY
    NIH/NHLBI R01HL046943Sep 1, 1993 - Aug 31, 2001
    Role: Principal Investigator
    NO2 INDUCED PEROXIDATION PRODUCTS AND AIRWAY REACTIVITY
    NIH/NHLBI R29HL046943Apr 1, 1992 - Apr 30, 1997
    Role: Co-Principal Investigator
    Hydroxynonenal induces glutathione synthesis through JNK
    NIH/NIEHS R01ES005511Apr 1, 1991 - Dec 30, 2011
    Role: Principal Investigator
    Reactive oxygen species in alveolar macrophage signaling
    NIH/NHLBI R01HL037556Apr 1, 1986 - Jun 30, 2007
    Role: Principal Investigator
    RADICALS AND CELLULAR FUNCTIONS IN OXYGEN TOXICITY
    NIH/NHLBI R01HL031831Apr 1, 1983 - Mar 31, 1986
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Pomatto LCD, Sun PY, Yu K, Gullapalli S, Bwiza CP, Sisliyan C, Wong S, Zhang H, Forman HJ, Oliver PL, Davies KE, Davies KJA. Limitations to adaptive homeostasis in an hyperoxia-induced model of accelerated ageing. Redox Biol. 2019 Jun; 24:101194. PMID: 31022673.
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    2. Pattammattel A, Leppert VJ, Forman HJ, O'Day PA. Surface characterization and chemical speciation of adsorbed iron(iii) on oxidized carbon nanoparticles. Environ Sci Process Impacts. 2019 Mar 20; 21(3):548-563. PMID: 30702742.
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    3. Davies KJA, Forman HJ. Does Bach1 & c-Myc dependent redox dysregulation of Nrf2 & adaptive homeostasis decrease cancer risk in ageing? Free Radic Biol Med. 2019 Jan 26. PMID: 30695691.
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    4. Zhou S, Dodia C, Feinstein SI, Harper S, Forman HJ, Speicher DW, Fisher AB. Oxidation of Peroxiredoxin 6 in the Presence of GSH Increases its Phospholipase A2 Activity at Cytoplasmic pH. Antioxidants (Basel). 2018 Dec 24; 8(1). PMID: 30586895.
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    5. Thorwald MA, Godoy-Lugo JA, Rodriguez GJ, Rodriguez MA, Jamal M, Kinoshita H, Nakano D, Nishiyama A, Forman HJ, Ortiz RM. Nrf2-related gene expression is impaired during a glucose challenge in type II diabetic rat hearts. Free Radic Biol Med. 2019 Jan; 130:306-317. PMID: 30316779.
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    6. van der Vliet A, Dick TP, Aust SD, Koppenol WH, Ursini F, Kettle AJ, Beckman JS, O'Donnell V, Darley-Usmar V, Lancaster J, Hogg N, Davies KJA, Forman HJ, Janssen-Heininger YMW. Rust never sleeps: The continuing story of the Iron Bolt. Free Radic Biol Med. 2018 Aug 20; 124:353-357. PMID: 29913216.
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    7. Pomatto LCD, Cline M, Woodward N, Pakbin P, Sioutas C, Morgan TE, Finch CE, Forman HJ, Davies KJA. Aging attenuates redox adaptive homeostasis and proteostasis in female mice exposed to traffic-derived nanoparticles ('vehicular smog'). Free Radic Biol Med. 2018 06; 121:86-97. PMID: 29709705.
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    8. Hegedus C, Kovács K, Polgár Z, Regdon Z, Szabó É, Robaszkiewicz A, Forman HJ, Martner A, Virág L. Redox control of cancer cell destruction. Redox Biol. 2018 06; 16:59-74. PMID: 29477046.
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    9. Forman HJ, Finch CE. A critical review of assays for hazardous components of air pollution. Free Radic Biol Med. 2018 03; 117:202-217. PMID: 29407794.
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    10. Davies JMS, Cillard J, Friguet B, Cadenas E, Cadet J, Cayce R, Fishmann A, Liao D, Bulteau AL, Derbré F, Rébillard A, Burstein S, Hirsch E, Kloner RA, Jakowec M, Petzinger G, Sauce D, Sennlaub F, Limon I, Ursini F, Maiorino M, Economides C, Pike CJ, Cohen P, Salvayre AN, Halliday MR, Lundquist AJ, Jakowec NA, Mechta-Grigoriou F, Mericskay M, Mariani J, Li Z, Huang D, Grant E, Forman HJ, Finch CE, Sun PY, Pomatto LCD, Agbulut O, Warburton D, Neri C, Rouis M, Cillard P, Capeau J, Rosenbaum J, Davies KJA. The Oxygen Paradox, the French Paradox, and age-related diseases. Geroscience. 2017 12; 39(5-6):499-550. PMID: 29270905.
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    11. Zhang H, Liu H, Zhou L, Yuen J, Forman HJ. Temporal changes in glutathione biosynthesis during the lipopolysaccharide-induced inflammatory response of THP-1 macrophages. Free Radic Biol Med. 2017 12; 113:304-310. PMID: 28993271.
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    12. Zhou L, Zhang H, Davies KJA, Forman HJ. Aging-related decline in the induction of Nrf2-regulated antioxidant genes in human bronchial epithelial cells. Redox Biol. 2018 04; 14:35-40. PMID: 28863281.
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    13. Skvortsova L, Perfelyeva A, Khussainova E, Mansharipova A, Forman HJ, Djansugurova L. Association of GCLM -588C/T and GCLC -129T/C Promoter Polymorphisms of Genes Coding the Subunits of Glutamate Cysteine Ligase with Ischemic Heart Disease Development in Kazakhstan Population. Dis Markers. 2017; 2017:4209257. PMID: 28757675.
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    14. Premshekharan G, Nguyen K, Zhang H, Forman HJ, Leppert VJ. Low dose inflammatory potential of silica particles in human-derived THP-1 macrophage cell culture studies - Mechanism and effects of particle size and iron. Chem Biol Interact. 2017 Jun 25; 272:160-171. PMID: 28512001.
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    15. Zhou L, Forman HJ, Ge Y, Lunec J. Multi-walled carbon nanotubes: A cytotoxicity study in relation to functionalization, dose and dispersion. Toxicol In Vitro. 2017 Aug; 42:292-298. PMID: 28483489.
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    16. Zhang H, Zhou L, Yuen J, Birkner N, Leppert V, O'Day PA, Forman HJ. Delayed Nrf2-regulated antioxidant gene induction in response to silica nanoparticles. Free Radic Biol Med. 2017 07; 108:311-319. PMID: 28389405.
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    17. Forman HJ, Koppenol WH. Introduction for the special issue on the chemistry of redox signaling. Arch Biochem Biophys. 2017 03 01; 617:1-2. PMID: 28088329.
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    18. Zhang H, Forman HJ. 4-hydroxynonenal-mediated signaling and aging. Free Radic Biol Med. 2017 10; 111:219-225. PMID: 27876535.
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    19. Zhang H, Forman HJ. Signaling by 4-hydroxy-2-nonenal: Exposure protocols, target selectivity and degradation. Arch Biochem Biophys. 2017 Mar 01; 617:145-154. PMID: 27840096.
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    20. Forman HJ, Davies MJ, Krämer AC, Miotto G, Zaccarin M, Zhang H, Ursini F. Protein cysteine oxidation in redox signaling: Caveats on sulfenic acid detection and quantification. Arch Biochem Biophys. 2017 Mar 01; 617:26-37. PMID: 27693037.
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    21. Forman HJ, Bernardo A, Davies KJ. Corrigendum to "What is the concentration of hydrogen peroxide in blood and plasma?" [Arch. Biochem. Biophys. 603 (2016) 48-53]. Arch Biochem Biophys. 2016 Oct 01; 607:7. PMID: 27552737.
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    22. Forman HJ. Redox signaling: An evolution from free radicals to aging. Free Radic Biol Med. 2016 08; 97:398-407. PMID: 27393004.
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    23. Cheng H, Saffari A, Sioutas C, Forman HJ, Morgan TE, Finch CE. Nanoscale Particulate Matter from Urban Traffic Rapidly Induces Oxidative Stress and Inflammation in Olfactory Epithelium with Concomitant Effects on Brain. Environ Health Perspect. 2016 Oct; 124(10):1537-1546. PMID: 27187980.
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    24. Forman HJ, Bernardo A, Davies KJ. What is the concentration of hydrogen peroxide in blood and plasma? Arch Biochem Biophys. 2016 08 01; 603:48-53. PMID: 27173735.
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    25. Forman HJ. Glutathione - From antioxidant to post-translational modifier. Arch Biochem Biophys. 2016 Apr 01; 595:64-7. PMID: 27095218.
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    26. Forman HJ, Toyokuni S. Tribute issue: Helmut Sies and oxidative stress: Venit, vidit, vicit. Arch Biochem Biophys. 2016 Apr 01; 595:2. PMID: 27095205.
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    27. Appenzeller-Herzog C, Bánhegyi G, Bogeski I, Davies KJ, Delaunay-Moisan A, Forman HJ, Görlach A, Kietzmann T, Laurindo F, Margittai E, Meyer AJ, Riemer J, Rützler M, Simmen T, Sitia R, Toledano MB, Touw IP. Transit of H2O2 across the endoplasmic reticulum membrane is not sluggish. Free Radic Biol Med. 2016 05; 94:157-60. PMID: 26928585.
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    28. Forman HJ, Davies KJA. Commentary on "Bach1 differentially regulates distinct Nrf2-dependent genes in human venous and coronary artery endothelial cells adapted to physiological oxygen levels" by Chapple et al. Free Radic Biol Med. 2016 Mar; 92:163-164. PMID: 26802904.
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    29. Ursini F, Maiorino M, Forman HJ. Redox homeostasis: The Golden Mean of healthy living. Redox Biol. 2016 08; 8:205-15. PMID: 26820564.
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    30. Zhang H, Forman HJ. 4-Hydroxynonenal activates Src through a non-canonical pathway that involves EGFR/PTP1B. Free Radic Biol Med. 2015 Dec; 89:701-7. PMID: 26453921.
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    31. Mann GE, Forman HJ. Introduction to Special Issue on 'Nrf2 Regulated Redox Signaling and Metabolism in Physiology and Medicine. Free Radic Biol Med. 2015 Nov; 88(Pt B):91-92. PMID: 26303332.
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    32. Cervellati C, Sticozzi C, Romani A, Belmonte G, De Rasmo D, Signorile A, Cervellati F, Milanese C, Mastroberardino PG, Pecorelli A, Savelli V, Forman HJ, Hayek J, Valacchi G. Impaired enzymatic defensive activity, mitochondrial dysfunction and proteasome activation are involved in RTT cell oxidative damage. Biochim Biophys Acta. 2015 Oct; 1852(10 Pt A):2066-74. PMID: 26189585.
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    33. Zhang H, Davies KJA, Forman HJ. Oxidative stress response and Nrf2 signaling in aging. Free Radic Biol Med. 2015 Nov; 88(Pt B):314-336. PMID: 26066302.
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    34. Zhang H, Davies KJ, Forman HJ. TGFß1 rapidly activates Src through a non-canonical redox signaling mechanism. Arch Biochem Biophys. 2015 Feb 15; 568:1-7. PMID: 25585026.
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    35. Bosello-Travain V, Forman HJ, Roveri A, Toppo S, Ursini F, Venerando R, Warnecke C, Zaccarin M, Maiorino M. Glutathione peroxidase 8 is transcriptionally regulated by HIFa and modulates growth factor signaling in HeLa cells. Free Radic Biol Med. 2015 Apr; 81:58-68. PMID: 25557012.
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    36. Zhang H, Forman HJ. TGFß1 rapidly activates Src through a non-canonical redox mechanism. Free Radic Biol Med. 2014 Oct; 75 Suppl 1:S4. PMID: 26461366.
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    37. Pecorelli A, Natrella F, Belmonte G, Miracco C, Cervellati F, Ciccoli L, Mariottini A, Rocchi R, Vatti G, Bua A, Canitano R, Hayek J, Forman HJ, Valacchi G. NADPH oxidase activation and 4-hydroxy-2-nonenal/aquaporin-4 adducts as possible new players in oxidative neuronal damage presents in drug-resistant epilepsy. Biochim Biophys Acta. 2015 Mar; 1852(3):507-19. PMID: 25460197.
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    38. Schwarzländer M, Wagner S, Ermakova YG, Belousov VV, Radi R, Beckman JS, Buettner GR, Demaurex N, Duchen MR, Forman HJ, Fricker MD, Gems D, Halestrap AP, Halliwell B, Jakob U, Johnston IG, Jones NS, Logan DC, Morgan B, Müller FL, Nicholls DG, Remington SJ, Schumacker PT, Winterbourn CC, Sweetlove LJ, Meyer AJ, Dick TP, Murphy MP. The 'mitoflash' probe cpYFP does not respond to superoxide. Nature. 2014 Oct 23; 514(7523):E12-4. PMID: 25341790.
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    39. Forman HJ, Augusto O, Brigelius-Flohe R, Dennery PA, Kalyanaraman B, Ischiropoulos H, Mann GE, Radi R, Roberts LJ, Vina J, Davies KJ. Even free radicals should follow some rules: a guide to free radical research terminology and methodology. Free Radic Biol Med. 2015 Jan; 78:233-5. PMID: 25462642.
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    40. Cervellati F, Muresan XM, Sticozzi C, Gambari R, Montagner G, Forman HJ, Torricelli C, Maioli E, Valacchi G. Comparative effects between electronic and cigarette smoke in human keratinocytes and epithelial lung cells. Toxicol In Vitro. 2014 Aug; 28(5):999-1005. PMID: 24809892.
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    41. Fisher AB, Forman HJ. Antioxidants in the intensive care unit. Am J Respir Crit Care Med. 2014 Apr 15; 189(8):1007-8. PMID: 24735038.
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    42. Qiu F, Chen YR, Liu X, Chu CY, Shen LJ, Xu J, Gaur S, Forman HJ, Zhang H, Zheng S, Yen Y, Huang J, Kung HJ, Ann DK. Arginine starvation impairs mitochondrial respiratory function in ASS1-deficient breast cancer cells. Sci Signal. 2014 Apr 01; 7(319):ra31. PMID: 24692592; PMCID: PMC4229039.
    43. Forman HJ, Ursini F, Maiorino M. An overview of mechanisms of redox signaling. J Mol Cell Cardiol. 2014 Aug; 73:2-9. PMID: 24512843.
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    44. Sticozzi C, Belmonte G, Cervellati F, Muresan XM, Pessina F, Lim Y, Forman HJ, Valacchi G. Resveratrol protects SR-B1 levels in keratinocytes exposed to cigarette smoke. Free Radic Biol Med. 2014 Apr; 69:50-7. PMID: 24423486.
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    45. Forman HJ, Traber M, Ursini F. Antioxidants: GRABbing new headlines. Free Radic Biol Med. 2014 Jan; 66:1-2. PMID: 24140709.
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    46. Andersen JK, Davies KJA, Forman HJ. Reactive oxygen and nitrogen species in neurodegeneration. Free Radic Biol Med. 2013 Sep; 62:1-3. PMID: 23876468.
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    47. Forman HJ, Davies KJ, Ursini F. How do nutritional antioxidants really work: nucleophilic tone and para-hormesis versus free radical scavenging in vivo. Free Radic Biol Med. 2014 Jan; 66:24-35. PMID: 23747930.
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    48. Forman HJ. Methods of lipid oxidation product identification and quantification. Free Radic Biol Med. 2013 Jun; 59:1. PMID: 23601748.
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    49. Chepelev NL, Zhang H, Liu H, McBride S, Seal AJ, Morgan TE, Finch CE, Willmore WG, Davies KJ, Forman HJ. Competition of nuclear factor-erythroid 2 factors related transcription factor isoforms, Nrf1 and Nrf2, in antioxidant enzyme induction. Redox Biol. 2013; 1:183-9. PMID: 24024152.
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    50. Zhang H, Forman HJ. Glutathione synthesis and its role in redox signaling. Semin Cell Dev Biol. 2012 Sep; 23(7):722-8. PMID: 22504020.
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    51. Sticozzi C, Belmonte G, Pecorelli A, Arezzini B, Gardi C, Maioli E, Miracco C, Toscano M, Forman HJ, Valacchi G. Cigarette smoke affects keratinocytes SRB1 expression and localization via H2O2 production and HNE protein adducts formation. PLoS One. 2012; 7(3):e33592. PMID: 22442701.
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    52. Zhang H, Liu H, Davies KJ, Sioutas C, Finch CE, Morgan TE, Forman HJ. Nrf2-regulated phase II enzymes are induced by chronic ambient nanoparticle exposure in young mice with age-related impairments. Free Radic Biol Med. 2012 May 01; 52(9):2038-46. PMID: 22401859.
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    53. Zhang H, Liu H, Borok Z, Davies KJ, Ursini F, Forman HJ. Cigarette smoke extract stimulates epithelial-mesenchymal transition through Src activation. Free Radic Biol Med. 2012 Apr 15; 52(8):1437-42. PMID: 22342303.
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    54. Pickering AM, Linder RA, Zhang H, Forman HJ, Davies KJ. Nrf2-dependent induction of proteasome and Pa28aß regulator are required for adaptation to oxidative stress. J Biol Chem. 2012 Mar 23; 287(13):10021-31. PMID: 22308036.
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    55. Mahaffey CM, Mahaffey NC, Holland W, Zhang H, Gandara DR, Mack PC, Forman HJ. Aberrant regulation of the MRP3 gene in non-small cell lung carcinoma. J Thorac Oncol. 2012 Jan; 7(1):34-9. PMID: 22089114; PMCID: PMC3241903.
    56. Vázquez-Medina JP, Zenteno-Savín T, Tift MS, Forman HJ, Crocker DE, Ortiz RM. Apnea stimulates the adaptive response to oxidative stress in elephant seal pups. J Exp Biol. 2011 Dec 15; 214(Pt 24):4193-200. PMID: 22116762.
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    57. Kalyanaraman B, Darley-Usmar V, Davies KJ, Dennery PA, Forman HJ, Grisham MB, Mann GE, Moore K, Roberts LJ, Ischiropoulos H. Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations. Free Radic Biol Med. 2012 Jan 01; 52(1):1-6. PMID: 22027063.
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    58. Premasekharan G, Nguyen K, Contreras J, Ramon V, Leppert VJ, Forman HJ. Iron-mediated lipid peroxidation and lipid raft disruption in low-dose silica-induced macrophage cytokine production. Free Radic Biol Med. 2011 Sep 15; 51(6):1184-94. PMID: 21741475.
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    59. Davies KJ, Forman HJ. RasGrf1 and aging. Aging (Albany NY). 2011 May; 3(5):455. PMID: 21666282.
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    60. Vázquez-Medina JP, Zenteno-Savín T, Forman HJ, Crocker DE, Ortiz RM. Prolonged fasting increases glutathione biosynthesis in postweaned northern elephant seals. J Exp Biol. 2011 Apr 15; 214(Pt 8):1294-9. PMID: 21430206.
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    61. Soñanez-Organis JG, Peregrino-Uriarte AB, Sotelo-Mundo RR, Forman HJ, Yepiz-Plascencia G. Hexokinase from the white shrimp Litopenaeus vannamei: cDNA sequence, structural protein model and regulation via HIF-1 in response to hypoxia. Comp Biochem Physiol B Biochem Mol Biol. 2011 Mar; 158(3):242-9. PMID: 21199679.
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    62. Forman HJ. Reactive oxygen species and alpha,beta-unsaturated aldehydes as second messengers in signal transduction. Ann N Y Acad Sci. 2010 Aug; 1203:35-44. PMID: 20716281.
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    63. Vázquez-Medina JP, Crocker DE, Forman HJ, Ortiz RM. Prolonged fasting does not increase oxidative damage or inflammation in postweaned northern elephant seal pups. J Exp Biol. 2010 Jul 15; 213(Pt 14):2524-30. PMID: 20581282.
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    64. Zhang H, Forman HJ. Reexamination of the electrophile response element sequences and context reveals a lack of consensus in gene function. Biochim Biophys Acta. 2010 Jul; 1799(7):496-501. PMID: 20478426.
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    65. Liu RM, Choi J, Wu JH, Gaston Pravia KA, Lewis KM, Brand JD, Mochel NS, Krzywanski DM, Lambeth JD, Hagood JS, Forman HJ, Thannickal VJ, Postlethwait EM. Oxidative modification of nuclear mitogen-activated protein kinase phosphatase 1 is involved in transforming growth factor beta1-induced expression of plasminogen activator inhibitor 1 in fibroblasts. J Biol Chem. 2010 May 21; 285(21):16239-47. PMID: 20228065; PMCID: PMC2871491.
    66. Levy S, Forman HJ. C-Myc is a Nrf2-interacting protein that negatively regulates phase II genes through their electrophile responsive elements. IUBMB Life. 2010 Mar; 62(3):237-46. PMID: 20232342.
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    67. Forman HJ, Maiorino M, Ursini F. Signaling functions of reactive oxygen species. Biochemistry. 2010 Feb 09; 49(5):835-42. PMID: 20050630.
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    68. Zhang H, Shih A, Rinna A, Forman HJ. Exacerbation of tobacco smoke mediated apoptosis by resveratrol: an unexpected consequence of its antioxidant action. Int J Biochem Cell Biol. 2011 Jul; 43(7):1059-64. PMID: 20060927.
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    69. Forman HJ. Critical methods in Free Radical Biology & Medicine. Free Radic Biol Med. 2009; 47 Suppl 2:S207. PMID: 19765645.
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    70. Forman HJ. Signal transduction and reactive species. Free Radic Biol Med. 2009 Nov 01; 47(9):1237-8. PMID: 19735727.
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    71. Zhang H, Forman HJ. Redox regulation of gamma-glutamyl transpeptidase. Am J Respir Cell Mol Biol. 2009 Nov; 41(5):509-15. PMID: 19684307.
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    72. Levy S, Jaiswal AK, Forman HJ. The role of c-Jun phosphorylation in EpRE activation of phase II genes. Free Radic Biol Med. 2009 Oct 15; 47(8):1172-9. PMID: 19666106.
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    73. Soñanez-Organis JG, Peregrino-Uriarte AB, Gómez-Jiménez S, López-Zavala A, Forman HJ, Yepiz-Plascencia G. Molecular characterization of hypoxia inducible factor-1 (HIF-1) from the white shrimp Litopenaeus vannamei and tissue-specific expression under hypoxia. Comp Biochem Physiol C Toxicol Pharmacol. 2009 Sep; 150(3):395-405. PMID: 19540931.
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    74. Zhang H, Forman HJ. Signaling pathways involved in phase II gene induction by alpha, beta-unsaturated aldehydes. Toxicol Ind Health. 2009 May-Jun; 25(4-5):269-78. PMID: 19651797.
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    75. Mahaffey CM, Zhang H, Rinna A, Holland W, Mack PC, Forman HJ. Multidrug-resistant protein-3 gene regulation by the transcription factor Nrf2 in human bronchial epithelial and non-small-cell lung carcinoma. Free Radic Biol Med. 2009 Jun 15; 46(12):1650-7. PMID: 19345732; PMCID: PMC2692873.
    76. Zhang H, Shih A, Rinna A, Forman HJ. Resveratrol and 4-hydroxynonenal act in concert to increase glutamate cysteine ligase expression and glutathione in human bronchial epithelial cells. Arch Biochem Biophys. 2009 Jan 01; 481(1):110-5. PMID: 18983812.
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    77. Chen JL, Lin HH, Kim KJ, Lin A, Forman HJ, Ann DK. Novel roles for protein kinase Cdelta-dependent signaling pathways in acute hypoxic stress-induced autophagy. J Biol Chem. 2008 Dec 05; 283(49):34432-44. PMID: 18836180.
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    78. Franklin CC, Backos DS, Mohar I, White CC, Forman HJ, Kavanagh TJ. Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase. Mol Aspects Med. 2009 Feb-Apr; 30(1-2):86-98. PMID: 18812186.
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    79. Bindoli A, Fukuto JM, Forman HJ. Thiol chemistry in peroxidase catalysis and redox signaling. Antioxid Redox Signal. 2008 Sep; 10(9):1549-64. PMID: 18479206.
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    80. Forman HJ, Zhang H, Rinna A. Glutathione: overview of its protective roles, measurement, and biosynthesis. Mol Aspects Med. 2009 Feb-Apr; 30(1-2):1-12. PMID: 18796312.
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    81. Forman HJ, Fukuto JM, Miller T, Zhang H, Rinna A, Levy S. The chemistry of cell signaling by reactive oxygen and nitrogen species and 4-hydroxynonenal. Arch Biochem Biophys. 2008 Sep 15; 477(2):183-95. PMID: 18602883.
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    82. Sunagawa S, Choi J, Forman HJ, Medina M. Hyperthermic stress-induced increase in the expression of glutamate-cysteine ligase and glutathione levels in the symbiotic sea anemone Aiptasia pallida. Comp Biochem Physiol B Biochem Mol Biol. 2008 Sep; 151(1):133-8. PMID: 18602489.
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    83. Ding Y, Choi KJ, Kim JH, Han X, Piao Y, Jeong JH, Choe W, Kang I, Ha J, Forman HJ, Lee J, Yoon KS, Kim SS. Endogenous hydrogen peroxide regulates glutathione redox via nuclear factor erythroid 2-related factor 2 downstream of phosphatidylinositol 3-kinase during muscle differentiation. Am J Pathol. 2008 Jun; 172(6):1529-41. PMID: 18458092.
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    84. Janssen-Heininger YM, Mossman BT, Heintz NH, Forman HJ, Kalyanaraman B, Finkel T, Stamler JS, Rhee SG, van der Vliet A. Redox-based regulation of signal transduction: principles, pitfalls, and promises. Free Radic Biol Med. 2008 Jul 01; 45(1):1-17. PMID: 18423411.
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    85. Rinna A, Forman HJ. SHP-1 inhibition by 4-hydroxynonenal activates Jun N-terminal kinase and glutamate cysteine ligase. Am J Respir Cell Mol Biol. 2008 Jul; 39(1):97-104. PMID: 18276794.
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    86. Zhang H, Forman HJ. Acrolein induces heme oxygenase-1 through PKC-delta and PI3K in human bronchial epithelial cells. Am J Respir Cell Mol Biol. 2008 Apr; 38(4):483-90. PMID: 18048804.
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    87. Forman HJ. Use and abuse of exogenous H2O2 in studies of signal transduction. Free Radic Biol Med. 2007 Apr 01; 42(7):926-32. PMID: 17349920.
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    88. Zhang H, Court N, Forman HJ. Submicromolar concentrations of 4-hydroxynonenal induce glutamate cysteine ligase expression in HBE1 cells. Redox Rep. 2007; 12(1):101-6. PMID: 17263920.
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    89. Liu H, Zhang H, Forman HJ. Silica induces macrophage cytokines through phosphatidylcholine-specific phospholipase C with hydrogen peroxide. Am J Respir Cell Mol Biol. 2007 May; 36(5):594-9. PMID: 17158358.
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    90. Cruz CM, Rinna A, Forman HJ, Ventura AL, Persechini PM, Ojcius DM. ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages. J Biol Chem. 2007 Feb 02; 282(5):2871-9. PMID: 17132626.
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    97. Martín ME, Muñoz FM, Dickinson DA, Forman HJ, Martín del Río R, Salinas M, Fando JL. Protective effect of L-trans-pyrrolidine-2,4-dicarboxilic acid preload against cell death induced by oxygen/glucose deprivation in differentiated PC12 cells. J Neurosci Res. 2005 Oct 01; 82(1):93-102. PMID: 16049970.
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    113. Thome U, Lazrak A, Chen L, Kirk MC, Thomas MJ, Forman HJ, Matalon S. Novel SIN-1 reactive intermediates modulate chloride secretion across murine airway cells. Free Radic Biol Med. 2003 Sep 15; 35(6):662-75. PMID: 12957658.
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    116. West JA, Van Winkle LS, Morin D, Fleschner CA, Forman HJ, Plopper CG. Repeated inhalation exposures to the bioactivated cytotoxicant naphthalene (NA) produce airway-specific Clara cell tolerance in mice. Toxicol Sci. 2003 Sep; 75(1):161-8. PMID: 12805647.
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    118. Watanabe N, Iwamoto T, Bowen KD, Dickinson DA, Torres M, Forman HJ. Bio-effectiveness of Tat-catalase conjugate: a potential tool for the identification of H2O2-dependent cellular signal transduction pathways. Biochem Biophys Res Commun. 2003 Mar 28; 303(1):287-93. PMID: 12646200.
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    162. Anderson CP, Tsai J, Chan W, Park CK, Tian L, Lui RM, Forman HJ, Reynolds CP. Buthionine sulphoximine alone and in combination with melphalan (L-PAM) is highly cytotoxic for human neuroblastoma cell lines. Eur J Cancer. 1997 Oct; 33(12):2016-9. PMID: 9516845.
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    194. Robison TW, Forman HJ. t-Butyl hydroperoxide stimulates alveolar macrophage biosynthesis of cyclooxygenase products. Prostaglandins. 1990 Jul; 40(1):13-28. PMID: 2117767.
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    195. Robison TW, Duncan DP, Forman HJ. Chemoattractant and leukotriene B4 production from rat alveolar macrophages exposed to nitrogen dioxide. Am J Respir Cell Mol Biol. 1990 Jul; 3(1):21-6. PMID: 2163652.
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    196. Robison TW, Duncan DP, Coates TD, Forman HJ. Inhibition of production of LTB4 and chemotactic agent from rat alveolar macrophages treated with t-butyl hydroperoxide is independent of ATP depletion. Biochim Biophys Acta. 1990 Jun 28; 1045(1):9-16. PMID: 2164422.
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    197. Forman HJ, Kim E. Inhibition by linoleic acid hydroperoxide of alveolar macrophage superoxide production: effects upon mitochondrial and plasma membrane potentials. Arch Biochem Biophys. 1989 Nov 01; 274(2):443-52. PMID: 2552924.
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    198. Warburton D, Buckley S, Cosico L, Forman HJ. Sublethal oxidant injury inhibits signal transduction in rat type II pneumocytes. Am J Physiol. 1989 Oct; 257(4 Pt 1):L217-20. PMID: 2552828.
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    199. Loeb GA, Skelton DC, Forman HJ. Dependence of mixed disulfide formation in alveolar macrophages upon production of oxidized glutathione: effect of selenium depletion. Biochem Pharmacol. 1989 Sep 15; 38(18):3119-21. PMID: 2783166.
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    200. Ryer-Powder JE, Forman HJ. Adhering lung macrophages produce superoxide demonstrated with desferal-Mn(IV). Free Radic Biol Med. 1989; 6(5):513-8. PMID: 2545553.
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    201. Robison TW, Duncan DP, Forman HJ. Kinetics of uptake and distribution of arachidonic acid by rat alveolar macrophages. Prostaglandins. 1988 Oct; 36(4):443-61. PMID: 3238001.
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    202. Dorio RJ, Hoek JB, Rubin E, Forman HJ. Ethanol modulation of rat alveolar macrophage superoxide production. Biochem Pharmacol. 1988 Sep 15; 37(18):3528-31. PMID: 2844192.
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    203. Dorio RJ, Forman HJ. Ethanol inhibition of signal transduction in superoxide production by rat alveolar macrophages. A proposed mechanism for ethanol related pneumonia. Ann Clin Lab Sci. 1988 May-Jun; 18(3):190-4. PMID: 2839095.
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    204. Forman HJ, Skelton DC, Loeb GA, Dorio RJ. Membrane permeability and oxidant induced injury. Basic Life Sci. 1988; 49:523-30. PMID: 2854997.
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    205. Loeb GA, Skelton DC, Coates TD, Forman HJ. Role of selenium-dependent glutathione peroxidase in antioxidant defenses in rat alveolar macrophages. Exp Lung Res. 1988; 14 Suppl:921-36. PMID: 3208729.
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    206. Forman HJ, Dorio RJ, Skelton DC. Hydroperoxide-induced damage to alveolar macrophage function and membrane integrity: alterations in intracellular-free Ca2+ and membrane potential. Arch Biochem Biophys. 1987 Dec; 259(2):457-65. PMID: 2827576.
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    207. Dorio RJ, Nelson J, Forman HJ. A dual role for calcium in regulation of superoxide generation by stimulated rat alveolar macrophages. Biochim Biophys Acta. 1987 Apr 22; 928(2):137-43. PMID: 3032276.
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    208. Forman HJ, Nelson J, Harrison G. Hyperoxia alters effect of calcium on rat alveolar macrophage superoxide production. J Appl Physiol (1985). 1986 Apr; 60(4):1300-5. PMID: 3009390.
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    209. Harrison G, Forman HJ. Progressive loss of the macrophage respiratory burst in oxygen toxicity. J Free Radic Biol Med. 1986; 2(2):129-34. PMID: 3819334.
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    210. Forman HJ, Thomas MJ. Oxidant production and bactericidal activity of phagocytes. Annu Rev Physiol. 1986; 48:669-80. PMID: 3010830.
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    211. Sutherland MW, Nelson J, Harrison G, Forman HJ. Effects of t-butyl hydroperoxide on NADPH, glutathione, and the respiratory burst of rat alveolar macrophages. Arch Biochem Biophys. 1985 Dec; 243(2):325-31. PMID: 3002274.
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    212. Glass M, Sutherland MW, Forman HJ, Fisher AB. Selenium deficiency potentiates paraquat-induced lipid peroxidation in isolated perfused rat lung. J Appl Physiol (1985). 1985 Aug; 59(2):619-22. PMID: 4030615.
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    213. Sutherland MW, Glass M, Nelson J, Lyen Y, Forman HJ. Oxygen toxicity: loss of lung macrophage function without metabolite depletion. J Free Radic Biol Med. 1985; 1(3):209-14. PMID: 3013977.
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    214. Fisher AB, Forman HJ, Glass M. Mechanisms of pulmonary oxygen toxicity. Lung. 1984; 162(5):255-9. PMID: 6392761.
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    215. Forman HJ, Rotman EI, Fisher AB. Roles of selenium and sulfur-containing amino acids in protection against oxygen toxicity. Lab Invest. 1983 Aug; 49(2):148-53. PMID: 6876743.
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    216. Cameron AR, Nelson J, Forman HJ. Depolarization and increased conductance precede superoxide release by concanavalin A-stimulated rat alveolar macrophages. Proc Natl Acad Sci U S A. 1983 Jun; 80(12):3726-8. PMID: 6304734.
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    217. Forman HJ, Nelson J. Effect of extracellular calcium on superoxide release by rat alveolar macrophages. J Appl Physiol Respir Environ Exerc Physiol. 1983 May; 54(5):1249-53. PMID: 6305896.
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    218. Aldrich TK, Fisher AB, Forman HJ. Paraquat inhibits mixed-function oxidation by rat lung. J Appl Physiol Respir Environ Exerc Physiol. 1983 Apr; 54(4):1089-93. PMID: 6853285.
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    219. Forman HJ, Williams JJ, Nelson J, Daniele RP, Fisher AB. Hyperoxia inhibits stimulated superoxide release by rat alveolar macrophages. J Appl Physiol Respir Environ Exerc Physiol. 1982 Sep; 53(3):685-9. PMID: 6290436.
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    220. Forman HJ, Aldrich TK, Posner MA, Fisher AB. Differential paraquat uptake and redox kinetics of rat granular pneumocytes and alveolar macrophages. J Pharmacol Exp Ther. 1982 May; 221(2):428-33. PMID: 7077538.
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    221. Jowa LB, Fisher AB, Forman HJ. Glucose-dependent chemiluminescence of resting rat alveolar macrophages. J Reticuloendothel Soc. 1981 Aug; 30(2):99-104. PMID: 7277359.
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    222. Forman HJ, Fisher AB. Antioxidant enzymes of rat granular pneumocytes. Constitutive levels and effect of hyperoxia. Lab Invest. 1981 Jul; 45(1):1-6. PMID: 6894775.
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    223. Forman HJ, Nelson J, Fisher AB. Rat alveolar macrophages require NADPH for superoxide production in the respiratory burst. Effect of NADPH depletion by paraquat. J Biol Chem. 1980 Oct 25; 255(20):9879-83. PMID: 6253456.
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    224. Arad ID, Forman HJ, Fisher AB. Ascorbate efflux from guinea pig and rat lungs. Effect of starvation and O2 exposure. J Lab Clin Med. 1980 Oct; 96(4):673-81. PMID: 6252268.
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    225. Kravetz G, Fisher AB, Forman HJ. The oxygen-adapted rat model: Tolerance to oxygen at 1.5 and 2 ATA. Aviat Space Environ Med. 1980 Aug; 51(8):775-7. PMID: 7417143.
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    226. Forman HJ, York JL, Fisher AB. Mechanism for the potentiation of oxygen toxicity by disulfiram. J Pharmacol Exp Ther. 1980 Mar; 212(3):452-5. PMID: 6244385.
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    227. Forman HJ, Kennedy J. Mammalian dihydroorotate dehydrogenase: physical and catalytic properties of the primary enzyme. Arch Biochem Biophys. 1978 Nov; 191(1):23-31. PMID: 216313.
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    228. Forman HJ, Kennedy J. Dihydroorotate-dependent superoxide production in rat brain and liver. A function of the primary dehydrogenase. Arch Biochem Biophys. 1976 Mar; 173(1):219-24. PMID: 176947.
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    229. Forman HJ, Kennedy J. Superoxide production and electron transport in mitochondrial oxidation of dihydroorotic acid. J Biol Chem. 1975 Jun 10; 250(11):4322-6. PMID: 165196.
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    230. Forman HJ, Kennedy JA. Role of superoxide radical in mitochondrial dehydrogenase reactions. Biochem Biophys Res Commun. 1974 Oct 08; 60(3):1044-50. PMID: 4372996.
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    231. Forman HJ, Waddell R, Hamilton PB, Grisolia S. Activation of carbamoyl phosphate synthase by N-acetyl-L-aspartate. Biochem J. 1974 Oct; 143(1):63-6. PMID: 4377221.
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    232. Forman HJ, Fridovich I. Superoxide dismutase: a comparison of rate constants. Arch Biochem Biophys. 1973 Sep; 158(1):396-400. PMID: 4354035.
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    233. Forman HJ, Evans HJ, Hill RL, Fridovich I. Histidine at the active site of superoxide dismutase. Biochemistry. 1973 Feb 27; 12(5):823-7. PMID: 4346922.
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    234. Brady FO, Monaco ME, Forman HJ, Schutz G, Feigelson P. On the role of copper in activation of and catalysis by tryptophan-2,3-dioxygenase. J Biol Chem. 1972 Dec 25; 247(24):7915-22. PMID: 4640930.
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    235. Forman HJ, Fridovich I. Electrolytic univalent reduction of oxygen in aqueous solution demonstrated with superoxide dismutase. Science. 1972 Jan 21; 175(4019):339. PMID: 17814545.
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    236. Brady FO, Forman HJ, Feigelson P. The role of superoxide and hydroperoxide in the reductive activation of tryptophan-2,3-dioxygenase. J Biol Chem. 1971 Dec 10; 246(23):7119-24. PMID: 5167018.
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    237. Forman HJ, Feigelson P. Kinetic evidence indicating the absence during catalysis of an unbound ferroprotoporphyrin form of tryptophan oxygenase. Biochemistry. 1971 Mar 02; 10(5):760-3. PMID: 5544666.
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