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Henry Jay Forman

TitleResearch Professor
InstitutionUniversity of Southern California
DepartmentGerontology
Address3715 McClintock Ave., Suite 306A
University Park Campus
Los Angeles CA 90089
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    Collapse Research 
    Collapse Research Activities and Funding
    Human models of the particulate-induced inflammatory/antioxidant axis in aging
    NIH/NIEHS R01ES023864Feb 9, 2015 - Nov 30, 2019
    Role: Principal Investigator
    Human models of the particulate-induced inflammatory/antioxidant axis in aging
    NIH/NIEHS R56ES023864Jun 1, 2014 - May 31, 2015
    Role: Principal Investigator
    Oxidative activation of Src in smoke-induced epithelial mesenchymal transition
    NIH/NIEHS R21ES020942Sep 1, 2012 - Aug 31, 2014
    Role: Principal Investigator
    2006 Oxygen Radicals in Biology Gordon Conferences
    NIH/NHLBI R13HL083487Aug 10, 2005 - Jul 31, 2006
    Role: Principal Investigator
    Hydroxynonenal induces glutathione synthesis through JNK
    NIH/NIEHS R56ES005511Apr 15, 1996 - Mar 31, 2007
    Role: Principal Investigator
    NO2 INDUCED PEROXIDATION PRODUCTS AND AIRWAY REACTIVITY
    NIH/NHLBI R01HL046943Sep 1, 1993 - Aug 31, 2001
    Role: Principal Investigator
    NO2 INDUCED PEROXIDATION PRODUCTS AND AIRWAY REACTIVITY
    NIH/NHLBI R29HL046943Apr 1, 1992 - Apr 30, 1997
    Role: Co-Principal Investigator
    Hydroxynonenal induces glutathione synthesis through JNK
    NIH/NIEHS R01ES005511Apr 1, 1991 - Dec 30, 2011
    Role: Principal Investigator
    Reactive oxygen species in alveolar macrophage signaling
    NIH/NHLBI R01HL037556Apr 1, 1986 - Jun 30, 2007
    Role: Principal Investigator
    RADICALS AND CELLULAR FUNCTIONS IN OXYGEN TOXICITY
    NIH/NHLBI R01HL031831Apr 1, 1983 - Mar 31, 1986
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Pomatto LCD, Cline M, Woodward N, Pakbin P, Sioutas C, Morgan TE, Finch CE, Forman H, Davies KJA. Aging attenuates redox adaptive homeostasis and proteostasis in female mice exposed to traffic-derived nanoparticles ('vehicular smog'). Free Radic Biol Med. 2018 Apr 27; 121:86-97. PMID: 29709705.
      View in: PubMed
    2. Hegedus C, Kovács K, Polgár Z, Regdon Z, Szabó É, Robaszkiewicz A, Forman H, Martner A, Virág L. Redox control of cancer cell destruction. Redox Biol. 2018 Jun; 16:59-74. PMID: 29477046.
      View in: PubMed
    3. Forman H, Finch CE. A critical review of assays for hazardous components of air pollution. Free Radic Biol Med. 2018 Mar; 117:202-217. PMID: 29407794.
      View in: PubMed
    4. Davies JMS, Cillard J, Friguet B, Cadenas E, Cadet J, Cayce R, Fishmann A, Liao D, Bulteau AL, Derbré F, Rébillard A, Burstein S, Hirsch E, Kloner RA, Jakowec M, Petzinger G, Sauce D, Sennlaub F, Limon I, Ursini F, Maiorino M, Economides C, Pike CJ, Cohen P, Salvayre AN, Halliday MR, Lundquist AJ, Jakowec NA, Mechta-Grigoriou F, Mericskay M, Mariani J, Li Z, Huang D, Grant E, Forman H, Finch CE, Sun PY, Pomatto LCD, Agbulut O, Warburton D, Neri C, Rouis M, Cillard P, Capeau J, Rosenbaum J, Davies KJA. The Oxygen Paradox, the French Paradox, and age-related diseases. Geroscience. 2017 12; 39(5-6):499-550. PMID: 29270905.
      View in: PubMed
    5. Zhang H, Liu H, Zhou L, Yuen J, Forman H. Temporal changes in glutathione biosynthesis during the lipopolysaccharide-induced inflammatory response of THP-1 macrophages. Free Radic Biol Med. 2017 Dec; 113:304-310. PMID: 28993271.
      View in: PubMed
    6. Zhou L, Zhang H, Davies KJA, Forman H. Aging-related decline in the induction of Nrf2-regulated antioxidant genes in human bronchial epithelial cells. Redox Biol. 2018 Apr; 14:35-40. PMID: 28863281.
      View in: PubMed
    7. Skvortsova L, Perfelyeva A, Khussainova E, Mansharipova A, Forman H, Djansugurova L. Association of GCLM -588C/T and GCLC -129T/C Promoter Polymorphisms of Genes Coding the Subunits of Glutamate Cysteine Ligase with Ischemic Heart Disease Development in Kazakhstan Population. Dis Markers. 2017; 2017:4209257. PMID: 28757675.
      View in: PubMed
    8. Premshekharan G, Nguyen K, Zhang H, Forman H, Leppert VJ. Low dose inflammatory potential of silica particles in human-derived THP-1 macrophage cell culture studies - Mechanism and effects of particle size and iron. Chem Biol Interact. 2017 Jun 25; 272:160-171. PMID: 28512001.
      View in: PubMed
    9. Zhou L, Forman H, Ge Y, Lunec J. Multi-walled carbon nanotubes: A cytotoxicity study in relation to functionalization, dose and dispersion. Toxicol In Vitro. 2017 Aug; 42:292-298. PMID: 28483489.
      View in: PubMed
    10. Zhang H, Zhou L, Yuen J, Birkner N, Leppert V, O'Day PA, Forman H. Delayed Nrf2-regulated antioxidant gene induction in response to silica nanoparticles. Free Radic Biol Med. 2017 Jul; 108:311-319. PMID: 28389405.
      View in: PubMed
    11. Forman H, Koppenol WH. Introduction for the special issue on the chemistry of redox signaling. Arch Biochem Biophys. 2017 03 01; 617:1-2. PMID: 28088329.
      View in: PubMed
    12. Zhang H, Forman H. 4-hydroxynonenal-mediated signaling and aging. Free Radic Biol Med. 2017 10; 111:219-225. PMID: 27876535.
      View in: PubMed
    13. Zhang H, Forman H. Signaling by 4-hydroxy-2-nonenal: Exposure protocols, target selectivity and degradation. Arch Biochem Biophys. 2017 Mar 01; 617:145-154. PMID: 27840096.
      View in: PubMed
    14. Forman H, Davies MJ, Krämer AC, Miotto G, Zaccarin M, Zhang H, Ursini F. Protein cysteine oxidation in redox signaling: Caveats on sulfenic acid detection and quantification. Arch Biochem Biophys. 2017 Mar 01; 617:26-37. PMID: 27693037.
      View in: PubMed
    15. Forman H, Bernardo A, Davies KJ. Corrigendum to "What is the concentration of hydrogen peroxide in blood and plasma?" [Arch. Biochem. Biophys. 603 (2016) 48-53]. Arch Biochem Biophys. 2016 Oct 01; 607:7. PMID: 27552737.
      View in: PubMed
    16. Forman H. Redox signaling: An evolution from free radicals to aging. Free Radic Biol Med. 2016 08; 97:398-407. PMID: 27393004.
      View in: PubMed
    17. Cheng H, Saffari A, Sioutas C, Forman H, Morgan TE, Finch CE. Nanoscale Particulate Matter from Urban Traffic Rapidly Induces Oxidative Stress and Inflammation in Olfactory Epithelium with Concomitant Effects on Brain. Environ Health Perspect. 2016 Oct; 124(10):1537-1546. PMID: 27187980.
      View in: PubMed
    18. Forman H, Bernardo A, Davies KJ. What is the concentration of hydrogen peroxide in blood and plasma? Arch Biochem Biophys. 2016 08 01; 603:48-53. PMID: 27173735.
      View in: PubMed
    19. Forman H. Glutathione - From antioxidant to post-translational modifier. Arch Biochem Biophys. 2016 Apr 01; 595:64-7. PMID: 27095218; PMCID: PMC4838773 [Available on 04/01/17].
    20. Forman H, Toyokuni S. Tribute issue: Helmut Sies and oxidative stress: Venit, vidit, vicit. Arch Biochem Biophys. 2016 Apr 01; 595:2. PMID: 27095205.
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    21. Appenzeller-Herzog C, Bánhegyi G, Bogeski I, Davies KJ, Delaunay-Moisan A, Forman H, Görlach A, Kietzmann T, Laurindo F, Margittai E, Meyer AJ, Riemer J, Rützler M, Simmen T, Sitia R, Toledano MB, Touw IP. Transit of H2O2 across the endoplasmic reticulum membrane is not sluggish. Free Radic Biol Med. 2016 05; 94:157-60. PMID: 26928585.
      View in: PubMed
    22. Forman H, Davies KJA. Commentary on "Bach1 differentially regulates distinct Nrf2-dependent genes in human venous and coronary artery endothelial cells adapted to physiological oxygen levels" by Chapple et al. Free Radic Biol Med. 2016 Mar; 92:163-164. PMID: 26802904.
      View in: PubMed
    23. Ursini F, Maiorino M, Forman H. Redox homeostasis: The Golden Mean of healthy living. Redox Biol. 2016 08; 8:205-15. PMID: 26820564; PMCID: PMC4732014.
    24. Zhang H, Forman H. 4-Hydroxynonenal activates Src through a non-canonical pathway that involves EGFR/PTP1B. Free Radic Biol Med. 2015 Dec; 89:701-7. PMID: 26453921; PMCID: PMC4684732 [Available on 12/01/16].
    25. Mann GE, Forman H. Introduction to Special Issue on 'Nrf2 Regulated Redox Signaling and Metabolism in Physiology and Medicine. Free Radic Biol Med. 2015 Nov; 88(Pt B):91-92. PMID: 26303332.
      View in: PubMed
    26. Cervellati C, Sticozzi C, Romani A, Belmonte G, De Rasmo D, Signorile A, Cervellati F, Milanese C, Mastroberardino PG, Pecorelli A, Savelli V, Forman H, Hayek J, Valacchi G. Impaired enzymatic defensive activity, mitochondrial dysfunction and proteasome activation are involved in RTT cell oxidative damage. Biochim Biophys Acta. 2015 Oct; 1852(10 Pt A):2066-74. PMID: 26189585.
      View in: PubMed
    27. Zhang H, Davies KJA, Forman H. Oxidative stress response and Nrf2 signaling in aging. Free Radic Biol Med. 2015 Nov; 88(Pt B):314-336. PMID: 26066302; PMCID: PMC4628850 [Available on 11/01/16].
    28. Zhang H, Davies KJ, Forman H. TGFß1 rapidly activates Src through a non-canonical redox signaling mechanism. Arch Biochem Biophys. 2015 Feb 15; 568:1-7. PMID: 25585026; PMCID: PMC4339486.
    29. Bosello-Travain V, Forman H, Roveri A, Toppo S, Ursini F, Venerando R, Warnecke C, Zaccarin M, Maiorino M. Glutathione peroxidase 8 is transcriptionally regulated by HIFa and modulates growth factor signaling in HeLa cells. Free Radic Biol Med. 2015 Apr; 81:58-68. PMID: 25557012.
      View in: PubMed
    30. Zhang H, Forman H. TGFß1 rapidly activates Src through a non-canonical redox mechanism. Free Radic Biol Med. 2014 Oct; 75 Suppl 1:S4. PMID: 26461366.
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    31. Schwarzländer M, Wagner S, Ermakova YG, Belousov VV, Radi R, Beckman JS, Buettner GR, Demaurex N, Duchen MR, Forman H, Fricker MD, Gems D, Halestrap AP, Halliwell B, Jakob U, Johnston IG, Jones NS, Logan DC, Morgan B, Müller FL, Nicholls DG, Remington SJ, Schumacker PT, Winterbourn CC, Sweetlove LJ, Meyer AJ, Dick TP, Murphy MP. The 'mitoflash' probe cpYFP does not respond to superoxide. Nature. 2014 Oct 23; 514(7523):E12-4. PMID: 25341790.
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    32. Forman H, Augusto O, Brigelius-Flohe R, Dennery PA, Kalyanaraman B, Ischiropoulos H, Mann GE, Radi R, Roberts LJ, Vina J, Davies KJ. Even free radicals should follow some rules: a guide to free radical research terminology and methodology. Free Radic Biol Med. 2015 Jan; 78:233-5. PMID: 25462642.
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    33. Fisher AB, Forman H. Antioxidants in the intensive care unit. Am J Respir Crit Care Med. 2014 Apr 15; 189(8):1007-8. PMID: 24735038.
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    34. Qiu F, Chen YR, Liu X, Chu CY, Shen LJ, Xu J, Gaur S, Forman H, Zhang H, Zheng S, Yen Y, Huang J, Kung HJ, Ann DK. Arginine starvation impairs mitochondrial respiratory function in ASS1-deficient breast cancer cells. Sci Signal. 2014 Apr 01; 7(319):ra31. PMID: 24692592; PMCID: PMC4229039.
    35. Forman H, Ursini F, Maiorino M. An overview of mechanisms of redox signaling. J Mol Cell Cardiol. 2014 Aug; 73:2-9. PMID: 24512843; PMCID: PMC4048798.
    36. Forman H, Traber M, Ursini F. Antioxidants: GRABbing new headlines. Free Radic Biol Med. 2014 Jan; 66:1-2. PMID: 24140709.
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    37. Andersen JK, Davies KJ, Forman H. Reactive oxygen and nitrogen species in neurodegeneration. Free Radic Biol Med. 2013 Sep; 62:1-3. PMID: 23876468.
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    38. Forman H, Davies KJ, Ursini F. How do nutritional antioxidants really work: nucleophilic tone and para-hormesis versus free radical scavenging in vivo. Free Radic Biol Med. 2014 Jan; 66:24-35. PMID: 23747930; PMCID: PMC3852196.
    39. Forman H. Methods of lipid oxidation product identification and quantification. Free Radic Biol Med. 2013 Jun; 59:1. PMID: 23601748.
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    40. Chepelev NL, Zhang H, Liu H, McBride S, Seal AJ, Morgan TE, Finch CE, Willmore WG, Davies KJ, Forman H. Competition of nuclear factor-erythroid 2 factors related transcription factor isoforms, Nrf1 and Nrf2, in antioxidant enzyme induction. Redox Biol. 2013; 1:183-9. PMID: 24024152; PMCID: PMC3757680.
    41. Zhang H, Forman H. Glutathione synthesis and its role in redox signaling. Semin Cell Dev Biol. 2012 Sep; 23(7):722-8. PMID: 22504020; PMCID: PMC3422610.
    42. Sticozzi C, Belmonte G, Pecorelli A, Arezzini B, Gardi C, Maioli E, Miracco C, Toscano M, Forman H, Valacchi G. Cigarette smoke affects keratinocytes SRB1 expression and localization via H2O2 production and HNE protein adducts formation. PLoS One. 2012; 7(3):e33592. PMID: 22442701; PMCID: PMC3307738.
    43. Zhang H, Liu H, Davies KJ, Sioutas C, Finch CE, Morgan TE, Forman H. Nrf2-regulated phase II enzymes are induced by chronic ambient nanoparticle exposure in young mice with age-related impairments. Free Radic Biol Med. 2012 May 01; 52(9):2038-46. PMID: 22401859; PMCID: PMC3342863.
    44. Zhang H, Liu H, Borok Z, Davies KJ, Ursini F, Forman H. Cigarette smoke extract stimulates epithelial-mesenchymal transition through Src activation. Free Radic Biol Med. 2012 Apr 15; 52(8):1437-42. PMID: 22342303; PMCID: PMC3312989.
    45. Pickering AM, Linder RA, Zhang H, Forman H, Davies KJ. Nrf2-dependent induction of proteasome and Pa28aß regulator are required for adaptation to oxidative stress. J Biol Chem. 2012 Mar 23; 287(13):10021-31. PMID: 22308036; PMCID: PMC3323025.
    46. Mahaffey CM, Mahaffey NC, Holland W, Zhang H, Gandara DR, Mack PC, Forman H. Aberrant regulation of the MRP3 gene in non-small cell lung carcinoma. J Thorac Oncol. 2012 Jan; 7(1):34-9. PMID: 22089114; PMCID: PMC3241903.
    47. Vázquez-Medina JP, Zenteno-Savín T, Tift MS, Forman H, Crocker DE, Ortiz RM. Apnea stimulates the adaptive response to oxidative stress in elephant seal pups. J Exp Biol. 2011 Dec 15; 214(Pt 24):4193-200. PMID: 22116762; PMCID: PMC3223118.
    48. Kalyanaraman B, Darley-Usmar V, Davies KJ, Dennery PA, Forman H, Grisham MB, Mann GE, Moore K, Roberts LJ, Ischiropoulos H. Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations. Free Radic Biol Med. 2012 Jan 01; 52(1):1-6. PMID: 22027063; PMCID: PMC3911769.
    49. Premasekharan G, Nguyen K, Contreras J, Ramon V, Leppert VJ, Forman H. Iron-mediated lipid peroxidation and lipid raft disruption in low-dose silica-induced macrophage cytokine production. Free Radic Biol Med. 2011 Sep 15; 51(6):1184-94. PMID: 21741475.
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    50. Davies KJ, Forman H. RasGrf1 and aging. Aging (Albany NY). 2011 May; 3(5):455. PMID: 21666282; PMCID: PMC3156594.
    51. Vázquez-Medina JP, Zenteno-Savín T, Forman H, Crocker DE, Ortiz RM. Prolonged fasting increases glutathione biosynthesis in postweaned northern elephant seals. J Exp Biol. 2011 Apr 15; 214(Pt 8):1294-9. PMID: 21430206; PMCID: PMC3063111.
    52. Soñanez-Organis JG, Peregrino-Uriarte AB, Sotelo-Mundo RR, Forman H, Yepiz-Plascencia G. Hexokinase from the white shrimp Litopenaeus vannamei: cDNA sequence, structural protein model and regulation via HIF-1 in response to hypoxia. Comp Biochem Physiol B Biochem Mol Biol. 2011 Mar; 158(3):242-9. PMID: 21199679.
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    53. Forman H. Reactive oxygen species and alpha,beta-unsaturated aldehydes as second messengers in signal transduction. Ann N Y Acad Sci. 2010 Aug; 1203:35-44. PMID: 20716281; PMCID: PMC4226340.
    54. Vázquez-Medina JP, Crocker DE, Forman H, Ortiz RM. Prolonged fasting does not increase oxidative damage or inflammation in postweaned northern elephant seal pups. J Exp Biol. 2010 Jul 15; 213(Pt 14):2524-30. PMID: 20581282; PMCID: PMC2892425.
    55. Zhang H, Forman H. Reexamination of the electrophile response element sequences and context reveals a lack of consensus in gene function. Biochim Biophys Acta. 2010 Jul; 1799(7):496-501. PMID: 20478426; PMCID: PMC2893253.
    56. Liu RM, Choi J, Wu JH, Gaston Pravia KA, Lewis KM, Brand JD, Mochel NS, Krzywanski DM, Lambeth JD, Hagood JS, Forman H, Thannickal VJ, Postlethwait EM. Oxidative modification of nuclear mitogen-activated protein kinase phosphatase 1 is involved in transforming growth factor beta1-induced expression of plasminogen activator inhibitor 1 in fibroblasts. J Biol Chem. 2010 May 21; 285(21):16239-47. PMID: 20228065; PMCID: PMC2871491.
    57. Levy S, Forman H. C-Myc is a Nrf2-interacting protein that negatively regulates phase II genes through their electrophile responsive elements. IUBMB Life. 2010 Mar; 62(3):237-46. PMID: 20232342; PMCID: PMC2852429.
    58. Forman H, Maiorino M, Ursini F. Signaling functions of reactive oxygen species. Biochemistry. 2010 Feb 09; 49(5):835-42. PMID: 20050630; PMCID: PMC4226395.
    59. Zhang H, Shih A, Rinna A, Forman H. Exacerbation of tobacco smoke mediated apoptosis by resveratrol: an unexpected consequence of its antioxidant action. Int J Biochem Cell Biol. 2011 Jul; 43(7):1059-64. PMID: 20060927; PMCID: PMC2891685.
    60. Forman H. Critical methods in Free Radical Biology & Medicine. Free Radic Biol Med. 2009; 47 Suppl 2:S207. PMID: 19765645.
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    61. Forman H. Signal transduction and reactive species. Free Radic Biol Med. 2009 Nov 01; 47(9):1237-8. PMID: 19735727.
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    62. Zhang H, Forman H. Redox regulation of gamma-glutamyl transpeptidase. Am J Respir Cell Mol Biol. 2009 Nov; 41(5):509-15. PMID: 19684307; PMCID: PMC2778158.
    63. Levy S, Jaiswal AK, Forman H. The role of c-Jun phosphorylation in EpRE activation of phase II genes. Free Radic Biol Med. 2009 Oct 15; 47(8):1172-9. PMID: 19666106; PMCID: PMC2759772.
    64. Soñanez-Organis JG, Peregrino-Uriarte AB, Gómez-Jiménez S, López-Zavala A, Forman H, Yepiz-Plascencia G. Molecular characterization of hypoxia inducible factor-1 (HIF-1) from the white shrimp Litopenaeus vannamei and tissue-specific expression under hypoxia. Comp Biochem Physiol C Toxicol Pharmacol. 2009 Sep; 150(3):395-405. PMID: 19540931.
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    65. Zhang H, Forman H. Signaling pathways involved in phase II gene induction by alpha, beta-unsaturated aldehydes. Toxicol Ind Health. 2009 May-Jun; 25(4-5):269-78. PMID: 19651797; PMCID: PMC2810153.
    66. Mahaffey CM, Zhang H, Rinna A, Holland W, Mack PC, Forman H. Multidrug-resistant protein-3 gene regulation by the transcription factor Nrf2 in human bronchial epithelial and non-small-cell lung carcinoma. Free Radic Biol Med. 2009 Jun 15; 46(12):1650-7. PMID: 19345732; PMCID: PMC2692873.
    67. Zhang H, Shih A, Rinna A, Forman H. Resveratrol and 4-hydroxynonenal act in concert to increase glutamate cysteine ligase expression and glutathione in human bronchial epithelial cells. Arch Biochem Biophys. 2009 Jan 01; 481(1):110-5. PMID: 18983812; PMCID: PMC2692270.
    68. Chen JL, Lin HH, Kim KJ, Lin A, Forman H, Ann DK. Novel roles for protein kinase Cdelta-dependent signaling pathways in acute hypoxic stress-induced autophagy. J Biol Chem. 2008 Dec 05; 283(49):34432-44. PMID: 18836180; PMCID: PMC2590682.
    69. Franklin CC, Backos DS, Mohar I, White CC, Forman H, Kavanagh TJ. Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase. Mol Aspects Med. 2009 Feb-Apr; 30(1-2):86-98. PMID: 18812186; PMCID: PMC2714364.
    70. Bindoli A, Fukuto JM, Forman H. Thiol chemistry in peroxidase catalysis and redox signaling. Antioxid Redox Signal. 2008 Sep; 10(9):1549-64. PMID: 18479206; PMCID: PMC2693905.
    71. Forman H, Zhang H, Rinna A. Glutathione: overview of its protective roles, measurement, and biosynthesis. Mol Aspects Med. 2009 Feb-Apr; 30(1-2):1-12. PMID: 18796312; PMCID: PMC2696075.
    72. Forman H, Fukuto JM, Miller T, Zhang H, Rinna A, Levy S. The chemistry of cell signaling by reactive oxygen and nitrogen species and 4-hydroxynonenal. Arch Biochem Biophys. 2008 Sep 15; 477(2):183-95. PMID: 18602883; PMCID: PMC2590784.
    73. Sunagawa S, Choi J, Forman H, Medina M. Hyperthermic stress-induced increase in the expression of glutamate-cysteine ligase and glutathione levels in the symbiotic sea anemone Aiptasia pallida. Comp Biochem Physiol B Biochem Mol Biol. 2008 Sep; 151(1):133-8. PMID: 18602489; PMCID: PMC2732428.
    74. Ding Y, Choi KJ, Kim JH, Han X, Piao Y, Jeong JH, Choe W, Kang I, Ha J, Forman H, Lee J, Yoon KS, Kim SS. Endogenous hydrogen peroxide regulates glutathione redox via nuclear factor erythroid 2-related factor 2 downstream of phosphatidylinositol 3-kinase during muscle differentiation. Am J Pathol. 2008 Jun; 172(6):1529-41. PMID: 18458092; PMCID: PMC2408414.
    75. Janssen-Heininger YM, Mossman BT, Heintz NH, Forman H, Kalyanaraman B, Finkel T, Stamler JS, Rhee SG, van der Vliet A. Redox-based regulation of signal transduction: principles, pitfalls, and promises. Free Radic Biol Med. 2008 Jul 01; 45(1):1-17. PMID: 18423411; PMCID: PMC2453533.
    76. Rinna A, Forman H. SHP-1 inhibition by 4-hydroxynonenal activates Jun N-terminal kinase and glutamate cysteine ligase. Am J Respir Cell Mol Biol. 2008 Jul; 39(1):97-104. PMID: 18276794; PMCID: PMC2438451.
    77. Zhang H, Forman H. Acrolein induces heme oxygenase-1 through PKC-delta and PI3K in human bronchial epithelial cells. Am J Respir Cell Mol Biol. 2008 Apr; 38(4):483-90. PMID: 18048804.
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    78. Forman H. Use and abuse of exogenous H2O2 in studies of signal transduction. Free Radic Biol Med. 2007 Apr 01; 42(7):926-32. PMID: 17349920; PMCID: PMC1945171.
    79. Zhang H, Court N, Forman H. Submicromolar concentrations of 4-hydroxynonenal induce glutamate cysteine ligase expression in HBE1 cells. Redox Rep. 2007; 12(1):101-6. PMID: 17263920; PMCID: PMC2730489.
    80. Liu H, Zhang H, Forman H. Silica induces macrophage cytokines through phosphatidylcholine-specific phospholipase C with hydrogen peroxide. Am J Respir Cell Mol Biol. 2007 May; 36(5):594-9. PMID: 17158358; PMCID: PMC1899332.
    81. Cruz CM, Rinna A, Forman H, Ventura AL, Persechini PM, Ojcius DM. ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages. J Biol Chem. 2007 Feb 02; 282(5):2871-9. PMID: 17132626; PMCID: PMC2693903.
    82. Cantin AM, White TB, Cross CE, Forman H, Sokol RJ, Borowitz D. Antioxidants in cystic fibrosis. Conclusions from the CF antioxidant workshop, Bethesda, Maryland, November 11-12, 2003. Free Radic Biol Med. 2007 Jan 01; 42(1):15-31. PMID: 17157190; PMCID: PMC2696206.
    83. Choi J, Forman H, Ou JH, Lai MM, Seronello S, Nandipati A. Redox modulation of the hepatitis C virus replication complex is calcium dependent. Free Radic Biol Med. 2006 Nov 01; 41(9):1488-98. PMID: 17023276.
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    84. Liu H, Zhang H, Iles KE, Rinna A, Merrill G, Yodoi J, Torres M, Forman H. The ADP-stimulated NADPH oxidase activates the ASK-1/MKK4/JNK pathway in alveolar macrophages. Free Radic Res. 2006 Aug; 40(8):865-74. PMID: 17015265; PMCID: PMC2713795.
    85. Rinna A, Torres M, Forman H. Stimulation of the alveolar macrophage respiratory burst by ADP causes selective glutathionylation of protein tyrosine phosphatase 1B. Free Radic Biol Med. 2006 Jul 01; 41(1):86-91. PMID: 16781456; PMCID: PMC2696202.
    86. Chinta SJ, Kumar JM, Zhang H, Forman H, Andersen JK. Up-regulation of gamma-glutamyl transpeptidase activity following glutathione depletion has a compensatory rather than an inhibitory effect on mitochondrial complex I activity: implications for Parkinson's disease. Free Radic Biol Med. 2006 May 01; 40(9):1557-63. PMID: 16632116; PMCID: PMC2804072.
    87. Zhang H, Liu H, Dickinson DA, Liu RM, Postlethwait EM, Laperche Y, Forman H. gamma-Glutamyl transpeptidase is induced by 4-hydroxynonenal via EpRE/Nrf2 signaling in rat epithelial type II cells. Free Radic Biol Med. 2006 Apr 15; 40(8):1281-92. PMID: 16631518; PMCID: PMC2702664.
    88. Martín ME, Muñoz FM, Dickinson DA, Forman H, Martín del Río R, Salinas M, Fando JL. Protective effect of L-trans-pyrrolidine-2,4-dicarboxilic acid preload against cell death induced by oxygen/glucose deprivation in differentiated PC12 cells. J Neurosci Res. 2005 Oct 01; 82(1):93-102. PMID: 16049970.
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    89. Zhang H, Liu H, Iles KE, Liu RM, Postlethwait EM, Laperche Y, Forman H. 4-Hydroxynonenal induces rat gamma-glutamyl transpeptidase through mitogen-activated protein kinase-mediated electrophile response element/nuclear factor erythroid 2-related factor 2 signaling. Am J Respir Cell Mol Biol. 2006 Feb; 34(2):174-81. PMID: 16195535; PMCID: PMC2696200.
    90. Ridnour LA, Sim JE, Choi J, Dickinson DA, Forman H, Ahmad IM, Coleman MC, Hunt CR, Goswami PC, Spitz DR. Nitric oxide-induced resistance to hydrogen peroxide stress is a glutamate cysteine ligase activity-dependent process. Free Radic Biol Med. 2005 May 15; 38(10):1361-71. PMID: 15855054.
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    91. Iles KE, Dickinson DA, Wigley AF, Welty NE, Blank V, Forman H. HNE increases HO-1 through activation of the ERK pathway in pulmonary epithelial cells. Free Radic Biol Med. 2005 Aug 01; 39(3):355-64. PMID: 15993334; PMCID: PMC2798573.
    92. Zhang H, Dickinson DA, Liu RM, Forman H. 4-Hydroxynonenal increases gamma-glutamyl transpeptidase gene expression through mitogen-activated protein kinase pathways. Free Radic Biol Med. 2005 Feb 15; 38(4):463-71. PMID: 15649648; PMCID: PMC2801023.
    93. Zhang H, Forman H, Choi J. Gamma-glutamyl transpeptidase in glutathione biosynthesis. Methods Enzymol. 2005; 401:468-83. PMID: 16399403.
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    94. Dickinson DA, Levonen AL, Moellering DR, Arnold EK, Zhang H, Darley-Usmar VM, Forman H. Human glutamate cysteine ligase gene regulation through the electrophile response element. Free Radic Biol Med. 2004 Oct 15; 37(8):1152-9. PMID: 15451055.
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    95. Forman H, Dickinson DA. Introduction to serial reviews on 4-hydroxy-2-nonenal as a signaling molecule. Free Radic Biol Med. 2004 Sep 01; 37(5):594-6. PMID: 15288117.
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    96. Forman H, Fukuto JM, Torres M. Redox signaling: thiol chemistry defines which reactive oxygen and nitrogen species can act as second messengers. Am J Physiol Cell Physiol. 2004 Aug; 287(2):C246-56. PMID: 15238356.
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    97. Mirecki A, Fitzmaurice P, Ang L, Kalasinsky KS, Peretti FJ, Aiken SS, Wickham DJ, Sherwin A, Nobrega JN, Forman H, Kish SJ. Brain antioxidant systems in human methamphetamine users. J Neurochem. 2004 Jun; 89(6):1396-408. PMID: 15189342.
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    98. Forman H, Ruden D. Introduction to serial reviews on EpRE and its signaling pathway. Free Radic Biol Med. 2004 May 15; 36(10):1197-8. PMID: 15110383.
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    99. Krzywanski DM, Dickinson DA, Iles KE, Wigley AF, Franklin CC, Liu RM, Kavanagh TJ, Forman H. Variable regulation of glutamate cysteine ligase subunit proteins affects glutathione biosynthesis in response to oxidative stress. Arch Biochem Biophys. 2004 Mar 01; 423(1):116-25. PMID: 14871475.
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    100. Watanabe N, Dickinson DA, Liu RM, Forman H. Quinones and glutathione metabolism. Methods Enzymol. 2004; 378:319-40. PMID: 15038978.
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    101. Dickinson DA, Iles KE, Wigley AF, Forman H. Analysis of transcription factor remodeling in phase II gene expression with curcumin. Methods Enzymol. 2004; 378:302-18. PMID: 15038977.
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    102. Venglarik CJ, Giron-Calle J, Wigley AF, Malle E, Watanabe N, Forman H. Hypochlorous acid alters bronchial epithelial cell membrane properties and prevention by extracellular glutathione. J Appl Physiol (1985). 2003 Dec; 95(6):2444-52. PMID: 14514700.
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    103. Thome U, Lazrak A, Chen L, Kirk MC, Thomas MJ, Forman H, Matalon S. Novel SIN-1 reactive intermediates modulate chloride secretion across murine airway cells. Free Radic Biol Med. 2003 Sep 15; 35(6):662-75. PMID: 12957658.
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    104. Liu RM, Liu Y, Forman H, Olman M, Tarpey MM. Glutathione regulates transforming growth factor-beta-stimulated collagen production in fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2004 Jan; 286(1):L121-8. PMID: 12959930.
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    105. Forman H, Dickinson DA, Iles KE. HNE--signaling pathways leading to its elimination. Mol Aspects Med. 2003 Aug-Oct; 24(4-5):189-94. PMID: 12892996.
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    106. West JA, Van Winkle LS, Morin D, Fleschner CA, Forman H, Plopper CG. Repeated inhalation exposures to the bioactivated cytotoxicant naphthalene (NA) produce airway-specific Clara cell tolerance in mice. Toxicol Sci. 2003 Sep; 75(1):161-8. PMID: 12805647.
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    107. Dickinson DA, Moellering DR, Iles KE, Patel RP, Levonen AL, Wigley A, Darley-Usmar VM, Forman H. Cytoprotection against oxidative stress and the regulation of glutathione synthesis. Biol Chem. 2003 Apr; 384(4):527-37. PMID: 12751783.
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    108. Watanabe N, Iwamoto T, Bowen KD, Dickinson DA, Torres M, Forman H. Bio-effectiveness of Tat-catalase conjugate: a potential tool for the identification of H2O2-dependent cellular signal transduction pathways. Biochem Biophys Res Commun. 2003 Mar 28; 303(1):287-93. PMID: 12646200.
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    109. Watanabe N, Forman H. Autoxidation of extracellular hydroquinones is a causative event for the cytotoxicity of menadione and DMNQ in A549-S cells. Arch Biochem Biophys. 2003 Mar 01; 411(1):145-57. PMID: 12590933; PMCID: PMC2795776.
    110. Dickinson DA, Iles KE, Zhang H, Blank V, Forman H. Curcumin alters EpRE and AP-1 binding complexes and elevates glutamate-cysteine ligase gene expression. FASEB J. 2003 Mar; 17(3):473-5. PMID: 12514113.
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    111. Torres M, Forman H. Redox signaling and the MAP kinase pathways. Biofactors. 2003; 17(1-4):287-96. PMID: 12897450.
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    112. Forman H, Dickinson DA. Oxidative signaling and glutathione synthesis. Biofactors. 2003; 17(1-4):1-12. PMID: 12897423.
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    113. Forman H, Torres M. Reactive oxygen species and cell signaling: respiratory burst in macrophage signaling. Am J Respir Crit Care Med. 2002 Dec 15; 166(12 Pt 2):S4-8. PMID: 12471082.
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    114. Dickinson DA, Forman H. Glutathione in defense and signaling: lessons from a small thiol. Ann N Y Acad Sci. 2002 Nov; 973:488-504. PMID: 12485918.
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    115. Torres M, Forman H. Vanadate inhibition of protein tyrosine phosphatases mimics hydrogen peroxide in the activation of the ERK pathway in alveolar macrophages. Ann N Y Acad Sci. 2002 Nov; 973:345-8. PMID: 12485891.
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    116. Dickinson DA, Iles KE, Watanabe N, Iwamoto T, Zhang H, Krzywanski DM, Forman H. 4-hydroxynonenal induces glutamate cysteine ligase through JNK in HBE1 cells. Free Radic Biol Med. 2002 Oct 01; 33(7):974. PMID: 12361807.
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    117. Watanabe N, Dickinson DA, Krzywanski DM, Iles KE, Zhang H, Venglarik CJ, Forman H. A549 subclones demonstrate heterogeneity in toxicological sensitivity and antioxidant profile. Am J Physiol Lung Cell Mol Physiol. 2002 Oct; 283(4):L726-36. PMID: 12225949.
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    118. Watanabe N, Iwamoto T, Dickinson DA, Iles KE, Forman H. Activation of the mitochondrial caspase cascade in the absence of protein synthesis does not require c-Jun N-terminal kinase. Arch Biochem Biophys. 2002 Sep 15; 405(2):231-40. PMID: 12220537.
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    119. Dickinson DA, Forman H. Cellular glutathione and thiols metabolism. Biochem Pharmacol. 2002 Sep; 64(5-6):1019-26. PMID: 12213601.
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    120. Iles KE, Dickinson DA, Watanabe N, Iwamoto T, Forman H. AP-1 activation through endogenous H(2)O(2) generation by alveolar macrophages. Free Radic Biol Med. 2002 Jun 15; 32(12):1304-13. PMID: 12057768.
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    121. Forman H, Torres M, Fukuto J. Redox signaling. Mol Cell Biochem. 2002 May-Jun; 234-235(1-2):49-62. PMID: 12162460.
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    122. Girón-Calle J, Srivatsa K, Forman H. Priming of alveolar macrophage respiratory burst by H(2)O(2) is prevented by phosphatidylcholine-specific phospholipase C inhibitor Tricyclodecan-9-yl-xanthate (D609). J Pharmacol Exp Ther. 2002 Apr; 301(1):87-94. PMID: 11907161.
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    123. West JA, Williams KJ, Toskala E, Nishio SJ, Fleschner CA, Forman H, Buckpitt AR, Plopper CG. Induction of tolerance to naphthalene in Clara cells is dependent on a stable phenotypic adaptation favoring maintenance of the glutathione pool. Am J Pathol. 2002 Mar; 160(3):1115-27. PMID: 11891208; PMCID: PMC1867174.
    124. Moellering DR, Levonen AL, Go YM, Patel RP, Dickinson DA, Forman H, Darley-Usmar VM. Induction of glutathione synthesis by oxidized low-density lipoprotein and 1-palmitoyl-2-arachidonyl phosphatidylcholine: protection against quinone-mediated oxidative stress. Biochem J. 2002 Feb 15; 362(Pt 1):51-9. PMID: 11829739; PMCID: PMC1222359.
    125. Iles KE, Forman H. Macrophage signaling and respiratory burst. Immunol Res. 2002; 26(1-3):95-105. PMID: 12403349.
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