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    Gordon Lithgow

    TitlePart Time Lecturer
    SchoolSchool of Gerontology
    DepartmentGerontology
    Address3715 MCCLINTOCK AVE.
    University Park Campus
    Los Angeles California 90089
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Lucanic M, Plummer WT, Chen E, Harke J, Foulger AC, Onken B, Coleman-Hulbert AL, Dumas KJ, Guo S, Johnson E, Bhaumik D, Xue J, Crist AB, Presley MP, Harinath G, Sedore CA, Chamoli M, Kamat S, Chen MK, Angeli S, Chang C, Willis JH, Edgar D, Royal MA, Chao EA, Patel S, Garrett T, Ibanez-Ventoso C, Hope J, Kish JL, Guo M, Lithgow G, Driscoll M, Phillips PC. Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects. Nat Commun. 2017 Feb 21; 8:14256. PMID: 28220799.
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      2. Mark KA, Dumas KJ, Bhaumik D, Schilling B, Davis S, Oron TR, Sorensen DJ, Lucanic M, Brem RB, Melov S, Ramanathan A, Gibson BW, Lithgow G. Vitamin D Promotes Protein Homeostasis and Longevity via the Stress Response Pathway Genes skn-1, ire-1, and xbp-1. Cell Rep. 2016 Oct 25; 17(5):1227-1237. PMID: 27783938.
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      3. Chaudhuri J, Bose N, Gong J, Hall D, Rifkind A, Bhaumik D, Peiris TH, Chamoli M, Le CH, Liu J, Lithgow G, Ramanathan A, Xu XZ, Kapahi P. A Caenorhabditis elegans Model Elucidates a Conserved Role for TRPA1-Nrf Signaling in Reactive a-Dicarbonyl Detoxification. Curr Biol. 2016 Oct 12. PMID: 27773573.
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      4. Lucanic M, Garrett T, Yu I, Calahorro F, Asadi Shahmirzadi A, Miller A, Gill MS, Hughes RE, Holden-Dye L, Lithgow G. Chemical activation of a food deprivation signal extends lifespan. Aging Cell. 2016 Oct; 15(5):832-41. PMID: 27220516.
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      5. Kumar J, Barhydt T, Awasthi A, Lithgow G, Killilea DW, Kapahi P. Zinc Levels Modulate Lifespan through Multiple Longevity Pathways in Caenorhabditis elegans. PLoS One. 2016; 11(4):e0153513. PMID: 27078872.
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      6. Martins R, Lithgow G, Link W. Long live FOXO: unraveling the role of FOXO proteins in aging and longevity. Aging Cell. 2016 Apr; 15(2):196-207. PMID: 26643314.
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      7. Siddiqui A, Bhaumik D, Chinta SJ, Rane A, Rajagopalan S, Lieu CA, Lithgow G, Andersen JK. Mitochondrial Quality Control via the PGC1a-TFEB Signaling Pathway Is Compromised by Parkin Q311X Mutation But Independently Restored by Rapamycin. J Neurosci. 2015 Sep 16; 35(37):12833-44. PMID: 26377470.
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      8. Kennedy BK, Berger SL, Brunet A, Campisi J, Cuervo AM, Epel ES, Franceschi C, Lithgow G, Morimoto RI, Pessin JE, Rando TA, Richardson A, Schadt EE, Wyss-Coray T, Sierra F. Geroscience: linking aging to chronic disease. Cell. 2014 Nov 6; 159(4):709-13. PMID: 25417146.
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      9. Klang IM, Schilling B, Sorensen DJ, Sahu AK, Kapahi P, Andersen JK, Swoboda P, Killilea DW, Gibson BW, Lithgow G. Iron promotes protein insolubility and aging in C. elegans. Aging (Albany NY). 2014 Nov; 6(11):975-91. PMID: 25554795.
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      10. Angeli S, Barhydt T, Jacobs R, Killilea DW, Lithgow G, Andersen JK. Manganese disturbs metal and protein homeostasis in Caenorhabditis elegans. Metallomics. 2014 Oct; 6(10):1816-23. PMID: 25057947.
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      11. Epel ES, Lithgow G. Stress biology and aging mechanisms: toward understanding the deep connection between adaptation to stress and longevity. J Gerontol A Biol Sci Med Sci. 2014 Jun; 69 Suppl 1:S10-6. PMID: 24833580.
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      12. Brejning J, Nørgaard S, Schøler L, Morthorst TH, Jakobsen H, Lithgow G, Jensen LT, Olsen A. Loss of NDG-4 extends lifespan and stress resistance in Caenorhabditis elegans. Aging Cell. 2014 Feb; 13(1):156-64. PMID: 24286221.
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      13. Angeli S, Klang I, Sivapatham R, Mark K, Zucker D, Bhaumik D, Lithgow G, Andersen JK. A DNA synthesis inhibitor is protective against proteotoxic stressors via modulation of fertility pathways in Caenorhabditis elegans. Aging (Albany NY). 2013 Oct; 5(10):759-69. PMID: 24123581.
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      14. Lucanic M, Graham J, Scott G, Bhaumik D, Benz CC, Hubbard A, Lithgow G, Melov S. Age-related micro-RNA abundance in individual C. elegans. Aging (Albany NY). 2013 Jun; 5(6):394-411. PMID: 23793570.
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      15. Frankowski H, Alavez S, Spilman P, Mark KA, Nelson JD, Mollahan P, Rao RV, Chen SF, Lithgow G, Ellerby HM. Dimethyl sulfoxide and dimethyl formamide increase lifespan of C. elegans in liquid. Mech Ageing Dev. 2013 Mar; 134(3-4):69-78. PMID: 23313473.
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      16. Monroy A, Lithgow G, Alavez S. Curcumin and neurodegenerative diseases. Biofactors. 2013 Jan-Feb; 39(1):122-32. PMID: 23303664.
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      17. Peters TW, Rardin MJ, Czerwieniec G, Evani US, Reis-Rodrigues P, Lithgow G, Mooney SD, Gibson BW, Hughes RE. Tor1 regulates protein solubility in Saccharomyces cerevisiae. Mol Biol Cell. 2012 Dec; 23(24):4679-88. PMID: 23097491.
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      18. Lithgow G, Lord JM, Kirkland JL. Translating longevity research into healthspan. Longev Healthspan. 2012; 1:1. PMID: 24764507.
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      19. Lucanic M, Lithgow G, Alavez S. Pharmacological lifespan extension of invertebrates. Ageing Res Rev. 2013 Jan; 12(1):445-58. PMID: 22771382.
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      20. Chinta SJ, Ganesan A, Reis-Rodrigues P, Lithgow G, Andersen JK. Anti-inflammatory role of the isoflavone diadzein in lipopolysaccharide-stimulated microglia: implications for Parkinson's disease. Neurotox Res. 2013 Feb; 23(2):145-53. PMID: 22573480.
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      21. Page KE, White KN, McCrohan CR, Killilea DW, Lithgow G. Aluminium exposure disrupts elemental homeostasis in Caenorhabditis elegans. Metallomics. 2012 May; 4(5):512-22. PMID: 22534883.
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      22. Alavez S, Lithgow G. Pharmacological maintenance of protein homeostasis could postpone age-related disease. Aging Cell. 2012 Apr; 11(2):187-91. PMID: 22226190.
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      23. Reis-Rodrigues P, Czerwieniec G, Peters TW, Evani US, Alavez S, Gaman EA, Vantipalli M, Mooney SD, Gibson BW, Lithgow G, Hughes RE. Proteomic analysis of age-dependent changes in protein solubility identifies genes that modulate lifespan. Aging Cell. 2012 Feb; 11(1):120-7. PMID: 22103665.
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      24. Rogers AN, Chen D, McColl G, Czerwieniec G, Felkey K, Gibson BW, Hubbard A, Melov S, Lithgow G, Kapahi P. Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans. Cell Metab. 2011 Jul 6; 14(1):55-66. PMID: 21723504.
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      25. Lucanic M, Held JM, Vantipalli MC, Klang IM, Graham JB, Gibson BW, Lithgow G, Gill MS. N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans. Nature. 2011 May 12; 473(7346):226-9. PMID: 21562563.
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      26. Alavez S, Lithgow G. A new look at old compounds. Aging (Albany NY). 2011 Apr; 3(4):338-9. PMID: 21512207.
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      27. Alavez S, Vantipalli MC, Zucker DJ, Klang IM, Lithgow G. Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan. Nature. 2011 Apr 14; 472(7342):226-9. PMID: 21451522.
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      28. McColl G, Rogers AN, Alavez S, Hubbard AE, Melov S, Link CD, Bush AI, Kapahi P, Lithgow G. Insulin-like signaling determines survival during stress via posttranscriptional mechanisms in C. elegans. Cell Metab. 2010 Sep 8; 12(3):260-72. PMID: 20816092.
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      29. Bhaumik D, Scott GK, Schokrpur S, Patil CK, Orjalo AV, Rodier F, Lithgow G, Campisi J. MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8. Aging (Albany NY). 2009 Apr; 1(4):402-11. PMID: 20148189.
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      30. Benedetti MG, Foster AL, Vantipalli MC, White MP, Sampayo JN, Gill MS, Olsen A, Lithgow G. Compounds that confer thermal stress resistance and extended lifespan. Exp Gerontol. 2008 Oct; 43(10):882-91. PMID: 18755260.
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      31. Fisher AL, Page KE, Lithgow G, Nash L. The Caenorhabditis elegans K10C2.4 gene encodes a member of the fumarylacetoacetate hydrolase family: a Caenorhabditis elegans model of type I tyrosinemia. J Biol Chem. 2008 Apr 4; 283(14):9127-35. PMID: 18227072.
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      32. McColl G, Killilea DW, Hubbard AE, Vantipalli MC, Melov S, Lithgow G. Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans. J Biol Chem. 2008 Jan 4; 283(1):350-7. PMID: 17959600.
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      33. Pan KZ, Palter JE, Rogers AN, Olsen A, Chen D, Lithgow G, Kapahi P. Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans. Aging Cell. 2007 Feb; 6(1):111-9. PMID: 17266680.
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      34. Lithgow G. Why aging isn't regulated: a lamentation on the use of language in aging literature. Exp Gerontol. 2006 Oct; 41(10):890-3. PMID: 16959457.
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      35. Held JM, White MP, Fisher AL, Gibson BW, Lithgow G, Gill MS. DAF-12-dependent rescue of dauer formation in Caenorhabditis elegans by (25S)-cholestenoic acid. Aging Cell. 2006 Aug; 5(4):283-91. PMID: 16913876.
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      36. Olsen A, Vantipalli MC, Lithgow G. Lifespan extension of Caenorhabditis elegans following repeated mild hormetic heat treatments. Biogerontology. 2006 Aug; 7(4):221-30. PMID: 16826446.
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      37. Olsen A, Vantipalli MC, Lithgow G. Checkpoint proteins control survival of the postmitotic cells in Caenorhabditis elegans. Science. 2006 Jun 2; 312(5778):1381-5. PMID: 16741121.
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      38. Olsen A, Vantipalli MC, Lithgow G. Using Caenorhabditis elegans as a model for aging and age-related diseases. Ann N Y Acad Sci. 2006 May; 1067:120-8. PMID: 16803977.
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      39. Fisher AL, Lithgow G. The nuclear hormone receptor DAF-12 has opposing effects on Caenorhabditis elegans lifespan and regulates genes repressed in multiple long-lived worms. Aging Cell. 2006 Apr; 5(2):127-38. PMID: 16626392.
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      40. Lithgow G, Gill MS, Olsen A, Sampayo JN. Pharmacological intervention in invertebrate aging. Age (Dordr). 2005 Sep; 27(3):213-23. PMID: 23598654.
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      41. Lin YT, Hoang H, Hsieh SI, Rangel N, Foster AL, Sampayo JN, Lithgow G, Srinivasan C. Manganous ion supplementation accelerates wild type development, enhances stress resistance, and rescues the life span of a short-lived Caenorhabditis elegans mutant. Free Radic Biol Med. 2006 Apr 1; 40(7):1185-93. PMID: 16545686.
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      42. Warner H, Anderson J, Austad S, Bergamini E, Bredesen D, Butler R, Carnes BA, Clark BF, Cristofalo V, Faulkner J, Guarente L, Harrison DE, Kirkwood T, Lithgow G, Martin G, Masoro E, Melov S, Miller RA, Olshansky SJ, Partridge L, Pereira-Smith O, Perls T, Richardson A, Smith J, von Zglinicki T, Wang E, Wei JY, Williams TF. Science fact and the SENS agenda. What can we reasonably expect from ageing research? EMBO Rep. 2005 Nov; 6(11):1006-8. PMID: 16264422.
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      43. McColl G, Vantipalli MC, Lithgow G. The C. elegans ortholog of mammalian Ku70, interacts with insulin-like signaling to modulate stress resistance and life span. FASEB J. 2005 Oct; 19(12):1716-8. PMID: 16099946.
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      44. Jenkins NL, McColl G, Lithgow G. Fitness cost of extended lifespan in Caenorhabditis elegans. Proc Biol Sci. 2004 Dec 7; 271(1556):2523-6. PMID: 15590605.
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      45. Gill MS, Held JM, Fisher AL, Gibson BW, Lithgow G. Lipophilic regulator of a developmental switch in Caenorhabditis elegans. Aging Cell. 2004 Dec; 3(6):413-21. PMID: 15569358.
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      46. Sampayo JN, Lithgow G. S.W.A.T.--SOD weapons and tactics. Sci Aging Knowledge Environ. 2004 Jun 23; 2004(25):pe27. PMID: 15215539.
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      47. Sampayo JN, Gill MS, Lithgow G. Oxidative stress and aging--the use of superoxide dismutase/catalase mimetics to extend lifespan. Biochem Soc Trans. 2003 Dec; 31(Pt 6):1305-7. PMID: 14641049.
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      48. Sampayo JN, Olsen A, Lithgow G. Oxidative stress in Caenorhabditis elegans: protective effects of superoxide dismutase/catalase mimetics. Aging Cell. 2003 Dec; 2(6):319-26. PMID: 14677634.
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      49. Gill MS, Olsen A, Sampayo JN, Lithgow G. An automated high-throughput assay for survival of the nematode Caenorhabditis elegans. Free Radic Biol Med. 2003 Sep 15; 35(6):558-65. PMID: 12957648.
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      50. Muriel JM, Brannan M, Taylor K, Johnstone IL, Lithgow G, Tuckwell D. M142.2 (cut-6), a novel Caenorhabditis elegans matrix gene important for dauer body shape. Dev Biol. 2003 Aug 15; 260(2):339-51. PMID: 12921736.
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      51. Lithgow G. Does anti-aging equal anti-microbial? Sci Aging Knowledge Environ. 2003 Jun 25; 2003(25):PE16. PMID: 12844540.
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      52. Walker GA, Lithgow G. Lifespan extension in C. elegans by a molecular chaperone dependent upon insulin-like signals. Aging Cell. 2003 Apr; 2(2):131-9. PMID: 12882326.
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      53. Lithgow G, Gill MS. Physiology: Cost-free longevity in mice? Nature. 2003 Jan 9; 421(6919):125-6. PMID: 12520289.
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      54. GuhaThakurta D, Palomar L, Stormo GD, Tedesco P, Johnson TE, Walker DW, Lithgow G, Kim S, Link CD. Identification of a novel cis-regulatory element involved in the heat shock response in Caenorhabditis elegans using microarray gene expression and computational methods. Genome Res. 2002 May; 12(5):701-12. PMID: 11997337.
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      55. Lithgow G, Walker GA. Stress resistance as a determinate of C. elegans lifespan. Mech Ageing Dev. 2002 Apr; 123(7):765-71. PMID: 11869734.
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      56. Walker GA, White TM, McColl G, Jenkins NL, Babich S, Candido EP, Johnson TE, Lithgow G. Heat shock protein accumulation is upregulated in a long-lived mutant of Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci. 2001 Jul; 56(7):B281-7. PMID: 11445592.
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      57. Barsyte D, Lovejoy DA, Lithgow G. Longevity and heavy metal resistance in daf-2 and age-1 long-lived mutants of Caenorhabditis elegans. FASEB J. 2001 Mar; 15(3):627-34. PMID: 11259381.
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      58. Melov S, Ravenscroft J, Malik S, Gill MS, Walker DW, Clayton PE, Wallace DC, Malfroy B, Doctrow SR, Lithgow G. Extension of life-span with superoxide dismutase/catalase mimetics. Science. 2000 Sep 1; 289(5484):1567-9. PMID: 10968795.
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      59. Sampayo JN, Jenkins NL, Lithgow G. Using stress resistance to isolate novel longevity mutations in Caenorhabditis elegans. Ann N Y Acad Sci. 2000 Jun; 908:324-6. PMID: 10911977.
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      60. McColl G, Jenkins NL, Walker DW, Lithgow G. Testing evolutionary theories of aging. Ann N Y Acad Sci. 2000 Jun; 908:319-20. PMID: 10911975.
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      61. Walker DW, McColl G, Jenkins NL, Harris J, Lithgow G. Evolution of lifespan in C. elegans. Nature. 2000 May 18; 405(6784):296-7. PMID: 10830948.
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      62. Lithgow G, Andersen JK. The real Dorian Gray mouse. Bioessays. 2000 May; 22(5):410-3. PMID: 10797480.
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      63. Lithgow G. Stress response and aging in Caenorhabditis elegans. Results Probl Cell Differ. 2000; 29:131-48. PMID: 10838698.
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      64. Babar P, Adamson C, Walker GA, Walker DW, Lithgow G. P13-kinase inhibition induces dauer formation, thermotolerance and longevity in C. elegans. Neurobiol Aging. 1999 Sep-Oct; 20(5):513-9. PMID: 10638524.
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      65. Walker GA, Walker DW, Lithgow G. A relationship between thermotolerance and longevity in Caenorhabditis elegans. J Investig Dermatol Symp Proc. 1998 Aug; 3(1):6-10. PMID: 9732049.
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      66. Walker GA, Walker DW, Lithgow G. Genes that determine both thermotolerance and rate of aging in Caenorhabditis elegans. Ann N Y Acad Sci. 1998 Jun 30; 851:444-9. PMID: 9668638.
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      67. Johnson TE, Lithgow G, Murakami S. Hypothesis: interventions that increase the response to stress offer the potential for effective life prolongation and increased health. J Gerontol A Biol Sci Med Sci. 1996 Nov; 51(6):B392-5. PMID: 8914487.
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      68. Lithgow G. Invertebrate gerontology: the age mutations of Caenorhabditis elegans. Bioessays. 1996 Oct; 18(10):809-15. PMID: 8885718.
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      69. Lithgow G, Kirkwood TB. Mechanisms and evolution of aging. Science. 1996 Jul 5; 273(5271):80. PMID: 8658201.
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      70. Lithgow G, White TM, Melov S, Johnson TE. Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress. Proc Natl Acad Sci U S A. 1995 Aug 1; 92(16):7540-4. PMID: 7638227.
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      71. Melov S, Lithgow G, Fischer DR, Tedesco PM, Johnson TE. Increased frequency of deletions in the mitochondrial genome with age of Caenorhabditis elegans. Nucleic Acids Res. 1995 Apr 25; 23(8):1419-25. PMID: 7753635.
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      72. Vaupel JW, Johnson TE, Lithgow G. Rates of mortality in populations of Caenorhabditis elegans. Science. 1994 Nov 4; 266(5186):826; author reply 828. PMID: 7973641.
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      73. Lithgow G, White TM, Hinerfeld DA, Johnson TE. Thermotolerance of a long-lived mutant of Caenorhabditis elegans. J Gerontol. 1994 Nov; 49(6):B270-6. PMID: 7963273.
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      74. Brooks A, Lithgow G, Johnson TE. Mortality rates in a genetically heterogeneous population of Caenorhabditis elegans. Science. 1994 Feb 4; 263(5147):668-71. PMID: 8303273.
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      75. Johnson TE, Tedesco PM, Lithgow G. Comparing mutants, selective breeding, and transgenics in the dissection of aging processes of Caenorhabditis elegans. Genetica. 1993; 91(1-3):65-77. PMID: 8125279.
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      76. Johnson TE, Lithgow G. The search for the genetic basis of aging: the identification of gerontogenes in the nematode Caenorhabditis elegans. J Am Geriatr Soc. 1992 Sep; 40(9):936-45. PMID: 1355097.
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