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Gordon Lithgow

TitlePart-Time Lecturer
InstitutionUniversity of Southern California
DepartmentGerontology
Address3715 McClintock Ave., Suite 102
University Park Campus
Los Angeles CA 90089
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Peters TW, Nelson CS, Gerencser AA, Dumas KJ, Tavshanjian B, Chang KC, Lithgow GJ, Hughes RE. Natural Genetic Variation in Yeast Reveals That NEDD4 Is a Conserved Modifier of Mutant Polyglutamine Aggregation. G3 (Bethesda). 2018 Sep 11. PMID: 30194090.
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    2. Lucanic M, Garrett T, Gill MS, Lithgow GJ. A Simple Method for High Throughput Chemical Screening in Caenorhabditis Elegans. J Vis Exp. 2018 Mar 20; (133). PMID: 29630057.
      View in: PubMed
    3. Lithgow GJ, Driscoll M, Phillips P. A long journey to reproducible results. Nature. 2017 08 22; 548(7668):387-388. PMID: 28836615.
      View in: PubMed
    4. Leonoudakis D, Rane A, Angeli S, Lithgow GJ, Andersen JK, Chinta SJ. Anti-Inflammatory and Neuroprotective Role of Natural Product Securinine in Activated Glial Cells: Implications for Parkinson's Disease. Mediators Inflamm. 2017; 2017:8302636. PMID: 28473732.
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    5. Lucanic M, Plummer WT, Chen E, Harke J, Foulger AC, Onken B, Coleman-Hulbert AL, Dumas KJ, Guo S, Johnson E, Bhaumik D, Xue J, Crist AB, Presley MP, Harinath G, Sedore CA, Chamoli M, Kamat S, Chen MK, Angeli S, Chang C, Willis JH, Edgar D, Royal MA, Chao EA, Patel S, Garrett T, Ibanez-Ventoso C, Hope J, Kish JL, Guo M, Lithgow GJ, Driscoll M, Phillips PC. Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects. Nat Commun. 2017 Feb 21; 8:14256. PMID: 28220799.
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    6. Mark KA, Dumas KJ, Bhaumik D, Schilling B, Davis S, Oron TR, Sorensen DJ, Lucanic M, Brem RB, Melov S, Ramanathan A, Gibson BW, Lithgow GJ. Vitamin D Promotes Protein Homeostasis and Longevity via the Stress Response Pathway Genes skn-1, ire-1, and xbp-1. Cell Rep. 2016 10 25; 17(5):1227-1237. PMID: 27783938.
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    7. Chaudhuri J, Bose N, Gong J, Hall D, Rifkind A, Bhaumik D, Peiris TH, Chamoli M, Le CH, Liu J, Lithgow GJ, Ramanathan A, Xu XZS, Kapahi P. A Caenorhabditis elegans Model Elucidates a Conserved Role for TRPA1-Nrf Signaling in Reactive a-Dicarbonyl Detoxification. Curr Biol. 2016 Nov 21; 26(22):3014-3025. PMID: 27773573.
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    8. Lucanic M, Garrett T, Yu I, Calahorro F, Asadi Shahmirzadi A, Miller A, Gill MS, Hughes RE, Holden-Dye L, Lithgow GJ. Chemical activation of a food deprivation signal extends lifespan. Aging Cell. 2016 10; 15(5):832-41. PMID: 27220516.
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    9. Kumar J, Barhydt T, Awasthi A, Lithgow GJ, Killilea DW, Kapahi P. Zinc Levels Modulate Lifespan through Multiple Longevity Pathways in Caenorhabditis elegans. PLoS One. 2016; 11(4):e0153513. PMID: 27078872; PMCID: PMC4831763.
    10. Martins R, Lithgow GJ, Link W. Long live FOXO: unraveling the role of FOXO proteins in aging and longevity. Aging Cell. 2016 Apr; 15(2):196-207. PMID: 26643314; PMCID: PMC4783344.
    11. Siddiqui A, Bhaumik D, Chinta SJ, Rane A, Rajagopalan S, Lieu CA, Lithgow GJ, Andersen JK. Mitochondrial Quality Control via the PGC1a-TFEB Signaling Pathway Is Compromised by Parkin Q311X Mutation But Independently Restored by Rapamycin. J Neurosci. 2015 Sep 16; 35(37):12833-44. PMID: 26377470; PMCID: PMC4571606.
    12. Kennedy BK, Berger SL, Brunet A, Campisi J, Cuervo AM, Epel ES, Franceschi C, Lithgow GJ, Morimoto RI, Pessin JE, Rando TA, Richardson A, Schadt EE, Wyss-Coray T, Sierra F. Geroscience: linking aging to chronic disease. Cell. 2014 Nov 06; 159(4):709-13. PMID: 25417146; PMCID: PMC4852871.
    13. Klang IM, Schilling B, Sorensen DJ, Sahu AK, Kapahi P, Andersen JK, Swoboda P, Killilea DW, Gibson BW, Lithgow GJ. Iron promotes protein insolubility and aging in C. elegans. Aging (Albany NY). 2014 Nov; 6(11):975-91. PMID: 25554795; PMCID: PMC4276790.
    14. Angeli S, Barhydt T, Jacobs R, Killilea DW, Lithgow GJ, Andersen JK. Manganese disturbs metal and protein homeostasis in Caenorhabditis elegans. Metallomics. 2014 Oct; 6(10):1816-23. PMID: 25057947; PMCID: PMC4309368.
    15. Epel ES, Lithgow GJ. Stress biology and aging mechanisms: toward understanding the deep connection between adaptation to stress and longevity. J Gerontol A Biol Sci Med Sci. 2014 Jun; 69 Suppl 1:S10-6. PMID: 24833580; PMCID: PMC4022128.
    16. Brejning J, Nørgaard S, Schøler L, Morthorst TH, Jakobsen H, Lithgow GJ, Jensen LT, Olsen A. Loss of NDG-4 extends lifespan and stress resistance in Caenorhabditis elegans. Aging Cell. 2014 Feb; 13(1):156-64. PMID: 24286221; PMCID: PMC3919970.
    17. Angeli S, Klang I, Sivapatham R, Mark K, Zucker D, Bhaumik D, Lithgow GJ, Andersen JK. A DNA synthesis inhibitor is protective against proteotoxic stressors via modulation of fertility pathways in Caenorhabditis elegans. Aging (Albany NY). 2013 Oct; 5(10):759-69. PMID: 24123581; PMCID: PMC3838778.
    18. Lucanic M, Graham J, Scott G, Bhaumik D, Benz CC, Hubbard A, Lithgow GJ, Melov S. Age-related micro-RNA abundance in individual C. elegans. Aging (Albany NY). 2013 Jun; 5(6):394-411. PMID: 23793570; PMCID: PMC3824409.
    19. Frankowski H, Alavez S, Spilman P, Mark KA, Nelson JD, Mollahan P, Rao RV, Chen SF, Lithgow GJ, Ellerby HM. Dimethyl sulfoxide and dimethyl formamide increase lifespan of C. elegans in liquid. Mech Ageing Dev. 2013 Mar; 134(3-4):69-78. PMID: 23313473.
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    20. Monroy A, Lithgow GJ, Alavez S. Curcumin and neurodegenerative diseases. Biofactors. 2013 Jan-Feb; 39(1):122-32. PMID: 23303664; PMCID: PMC3578106.
    21. Peters TW, Rardin MJ, Czerwieniec G, Evani US, Reis-Rodrigues P, Lithgow GJ, Mooney SD, Gibson BW, Hughes RE. Tor1 regulates protein solubility in Saccharomyces cerevisiae. Mol Biol Cell. 2012 Dec; 23(24):4679-88. PMID: 23097491; PMCID: PMC3521677.
    22. Lithgow GJ, Lord JM, Kirkland JL. Translating longevity research into healthspan. Longev Healthspan. 2012; 1:1. PMID: 24764507; PMCID: PMC3886258.
    23. Lucanic M, Lithgow GJ, Alavez S. Pharmacological lifespan extension of invertebrates. Ageing Res Rev. 2013 Jan; 12(1):445-58. PMID: 22771382; PMCID: PMC3552093.
    24. Chinta SJ, Ganesan A, Reis-Rodrigues P, Lithgow GJ, Andersen JK. Anti-inflammatory role of the isoflavone diadzein in lipopolysaccharide-stimulated microglia: implications for Parkinson's disease. Neurotox Res. 2013 Feb; 23(2):145-53. PMID: 22573480; PMCID: PMC3597389.
    25. Page KE, White KN, McCrohan CR, Killilea DW, Lithgow GJ. Aluminium exposure disrupts elemental homeostasis in Caenorhabditis elegans. Metallomics. 2012 May; 4(5):512-22. PMID: 22534883; PMCID: PMC3589999.
    26. Alavez S, Lithgow GJ. Pharmacological maintenance of protein homeostasis could postpone age-related disease. Aging Cell. 2012 Apr; 11(2):187-91. PMID: 22226190; PMCID: PMC3306462.
    27. Reis-Rodrigues P, Czerwieniec G, Peters TW, Evani US, Alavez S, Gaman EA, Vantipalli M, Mooney SD, Gibson BW, Lithgow GJ, Hughes RE. Proteomic analysis of age-dependent changes in protein solubility identifies genes that modulate lifespan. Aging Cell. 2012 Feb; 11(1):120-7. PMID: 22103665; PMCID: PMC3437485.
    28. Rogers AN, Chen D, McColl G, Czerwieniec G, Felkey K, Gibson BW, Hubbard A, Melov S, Lithgow GJ, Kapahi P. Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans. Cell Metab. 2011 Jul 06; 14(1):55-66. PMID: 21723504; PMCID: PMC3220185.
    29. Lucanic M, Held JM, Vantipalli MC, Klang IM, Graham JB, Gibson BW, Lithgow GJ, Gill MS. N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans. Nature. 2011 May 12; 473(7346):226-9. PMID: 21562563; PMCID: PMC3093655.
    30. Alavez S, Lithgow GJ. A new look at old compounds. Aging (Albany NY). 2011 Apr; 3(4):338-9. PMID: 21512207; PMCID: PMC3117445.
    31. Alavez S, Vantipalli MC, Zucker DJ, Klang IM, Lithgow GJ. Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan. Nature. 2011 Apr 14; 472(7342):226-9. PMID: 21451522; PMCID: PMC3610427.
    32. McColl G, Rogers AN, Alavez S, Hubbard AE, Melov S, Link CD, Bush AI, Kapahi P, Lithgow GJ. Insulin-like signaling determines survival during stress via posttranscriptional mechanisms in C. elegans. Cell Metab. 2010 Sep 08; 12(3):260-72. PMID: 20816092; PMCID: PMC2945254.
    33. Bhaumik D, Scott GK, Schokrpur S, Patil CK, Orjalo AV, Rodier F, Lithgow GJ, Campisi J. MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8. Aging (Albany NY). 2009 Apr; 1(4):402-11. PMID: 20148189; PMCID: PMC2818025.
    34. Benedetti MG, Foster AL, Vantipalli MC, White MP, Sampayo JN, Gill MS, Olsen A, Lithgow GJ. Compounds that confer thermal stress resistance and extended lifespan. Exp Gerontol. 2008 Oct; 43(10):882-91. PMID: 18755260; PMCID: PMC2603168.
    35. Fisher AL, Page KE, Lithgow GJ, Nash L. The Caenorhabditis elegans K10C2.4 gene encodes a member of the fumarylacetoacetate hydrolase family: a Caenorhabditis elegans model of type I tyrosinemia. J Biol Chem. 2008 Apr 04; 283(14):9127-35. PMID: 18227072; PMCID: PMC2431024.
    36. McColl G, Killilea DW, Hubbard AE, Vantipalli MC, Melov S, Lithgow GJ. Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans. J Biol Chem. 2008 Jan 04; 283(1):350-7. PMID: 17959600; PMCID: PMC2739662.
    37. Pan KZ, Palter JE, Rogers AN, Olsen A, Chen D, Lithgow GJ, Kapahi P. Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans. Aging Cell. 2007 Feb; 6(1):111-9. PMID: 17266680; PMCID: PMC2745345.
    38. Lithgow GJ. Why aging isn't regulated: a lamentation on the use of language in aging literature. Exp Gerontol. 2006 Oct; 41(10):890-3. PMID: 16959457.
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    39. Held JM, White MP, Fisher AL, Gibson BW, Lithgow GJ, Gill MS. DAF-12-dependent rescue of dauer formation in Caenorhabditis elegans by (25S)-cholestenoic acid. Aging Cell. 2006 Aug; 5(4):283-91. PMID: 16913876.
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    40. Olsen A, Vantipalli MC, Lithgow GJ. Lifespan extension of Caenorhabditis elegans following repeated mild hormetic heat treatments. Biogerontology. 2006 Aug; 7(4):221-30. PMID: 16826446.
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    41. Olsen A, Vantipalli MC, Lithgow GJ. Checkpoint proteins control survival of the postmitotic cells in Caenorhabditis elegans. Science. 2006 Jun 02; 312(5778):1381-5. PMID: 16741121; PMCID: PMC2568993.
    42. Olsen A, Vantipalli MC, Lithgow GJ. Using Caenorhabditis elegans as a model for aging and age-related diseases. Ann N Y Acad Sci. 2006 May; 1067:120-8. PMID: 16803977.
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    43. Fisher AL, Lithgow GJ. The nuclear hormone receptor DAF-12 has opposing effects on Caenorhabditis elegans lifespan and regulates genes repressed in multiple long-lived worms. Aging Cell. 2006 Apr; 5(2):127-38. PMID: 16626392.
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    44. Lithgow GJ, Gill MS, Olsen A, Sampayo JN. Pharmacological intervention in invertebrate aging. Age (Dordr). 2005 Sep; 27(3):213-23. PMID: 23598654; PMCID: PMC3458493.
    45. Lin YT, Hoang H, Hsieh SI, Rangel N, Foster AL, Sampayo JN, Lithgow GJ, Srinivasan C. Manganous ion supplementation accelerates wild type development, enhances stress resistance, and rescues the life span of a short-lived Caenorhabditis elegans mutant. Free Radic Biol Med. 2006 Apr 01; 40(7):1185-93. PMID: 16545686.
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    46. Warner H, Anderson J, Austad S, Bergamini E, Bredesen D, Butler R, Carnes BA, Clark BF, Cristofalo V, Faulkner J, Guarente L, Harrison DE, Kirkwood T, Lithgow G, Martin G, Masoro E, Melov S, Miller RA, Olshansky SJ, Partridge L, Pereira-Smith O, Perls T, Richardson A, Smith J, von Zglinicki T, Wang E, Wei JY, Williams TF. Science fact and the SENS agenda. What can we reasonably expect from ageing research? EMBO Rep. 2005 Nov; 6(11):1006-8. PMID: 16264422; PMCID: PMC1371037.
    47. McColl G, Vantipalli MC, Lithgow GJ. The C. elegans ortholog of mammalian Ku70, interacts with insulin-like signaling to modulate stress resistance and life span. FASEB J. 2005 Oct; 19(12):1716-8. PMID: 16099946; PMCID: PMC1400606.
    48. Jenkins NL, McColl G, Lithgow GJ. Fitness cost of extended lifespan in Caenorhabditis elegans. Proc Biol Sci. 2004 Dec 07; 271(1556):2523-6. PMID: 15590605; PMCID: PMC1440519.
    49. Gill MS, Held JM, Fisher AL, Gibson BW, Lithgow GJ. Lipophilic regulator of a developmental switch in Caenorhabditis elegans. Aging Cell. 2004 Dec; 3(6):413-21. PMID: 15569358.
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    50. Sampayo JN, Lithgow GJ. S.W.A.T.--SOD weapons and tactics. Sci Aging Knowledge Environ. 2004 Jun 23; 2004(25):pe27. PMID: 15215539.
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    51. Sampayo JN, Olsen A, Lithgow GJ. Oxidative stress in Caenorhabditis elegans: protective effects of superoxide dismutase/catalase mimetics. Aging Cell. 2003 Dec; 2(6):319-26. PMID: 14677634.
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    52. Gill MS, Olsen A, Sampayo JN, Lithgow GJ. An automated high-throughput assay for survival of the nematode Caenorhabditis elegans. Free Radic Biol Med. 2003 Sep 15; 35(6):558-65. PMID: 12957648.
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    53. Muriel JM, Brannan M, Taylor K, Johnstone IL, Lithgow GJ, Tuckwell D. M142.2 (cut-6), a novel Caenorhabditis elegans matrix gene important for dauer body shape. Dev Biol. 2003 Aug 15; 260(2):339-51. PMID: 12921736.
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    54. Lithgow GJ. Does anti-aging equal anti-microbial? Sci Aging Knowledge Environ. 2003 Jun 25; 2003(25):PE16. PMID: 12844540.
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    55. Walker GA, Lithgow GJ. Lifespan extension in C. elegans by a molecular chaperone dependent upon insulin-like signals. Aging Cell. 2003 Apr; 2(2):131-9. PMID: 12882326.
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    56. Lithgow GJ, Gill MS. Physiology: Cost-free longevity in mice? Nature. 2003 Jan 09; 421(6919):125-6. PMID: 12520289.
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    57. GuhaThakurta D, Palomar L, Stormo GD, Tedesco P, Johnson TE, Walker DW, Lithgow G, Kim S, Link CD. Identification of a novel cis-regulatory element involved in the heat shock response in Caenorhabditis elegans using microarray gene expression and computational methods. Genome Res. 2002 May; 12(5):701-12. PMID: 11997337; PMCID: PMC186591.
    58. Lithgow GJ, Walker GA. Stress resistance as a determinate of C. elegans lifespan. Mech Ageing Dev. 2002 Apr; 123(7):765-71. PMID: 11869734.
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