Fred R Sattler, MD

TitleProfessor of Medicine
InstitutionUniversity of Southern California
AddressIRD 436
Off Campus
Los Angeles CA 90089-9520
Phone+1 323 226 4635
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    Other Positions
    TitleChief, Division of Infectious Diseases

    Collapse Biography 
    Collapse Awards and Honors
    Phi Beta Kappa1969Elected Member
    National Institutes of Allergy and Infectious Diseases1977  - 1979National Research Fellowship Award
    Pennsylvania State University 1981Outstanding Instructor Award

    Collapse Overview 
    Collapse Overview
    Dr. Fred Sattler is Chief of the Division of Infectious Diseases, which is steadily growing in numbers and stature both within the University and in the scientific community. The Division provides enormous 1) consultative service to the local teaching hospital affiliated with the University of Southern California, 2) primary care to nearly 3000 HIV infected ambulatory patients, and 3) oversight of the epidemiology programs at the teaching hospitals.

    Dr. Sattler is principal investigator of the AIDS Clinical Trials Unit at USC of the NIAID funded AIDS Clinical Trials Group. The grant is currently in its 19th year of funding at USC. Dr. Sattler has provided scientific leadership for nearly two decades, most recently in studies that evaluate the pathophysiology and management of HIV associated weight loss, changes in body fat and metabolic complications. He continues to serve as a chair, co-chair, vice-chair, or protocol team member for a number of studies including ACTG 313, 329, 392, 892, 5079, 5112s, 5116s, 5124s and 5125s and along with other studies in planning. As an outgrowth of studies of AIDS muscle wasting, Dr. Sattler conducted investigator-initiated pilot studies in the USC GCRC to evaluate the effects of anabolic androgens in elderly subjects with loss of skeletal muscle mass (sarcopenia) and muscle strength and who are thus at risk for frailty and who have gains in central fat and are at risk for the metabolic syndrome. These studies have demonstrated dose dependent improvements in muscle mass, maximal voluntary strength, and leg power, which are necessary constituents for physical function, independence, and quality of life during aging. Study subjects also experienced a dose-related decrease in total and central fat as an additional response to study intervention.

    Based on the results of these studies which have been presented in at the Endocrine Society meetings, Dr. Sattler obtained commitments from Genentech, Tap, Solvay pharmaceutical companies to supply rhGH (recombinant human growth hormone), leuprolide acetate, and a new, more physiologic topical formulation of testosterone to study the interactions of the growth hormone/IGF-1 and hypothalamic-pituitary-gonadal axes in regulating muscle and adipose tissue in elderly persons. These activities culminated in his being funded by the National Institutes of Aging as PI to conduct a multicenter four-year study to evaluate the effects of restoring these hormonal axes to youthful levels on net anabolic protein balance. The translational effects of these interventions as measured by net anabolic balance of skeletal muscle protein synthesis and breakdown, body composition (DEXA, MRI and total body water analysis by stable isotope biology), anthropometry, skeletal muscle strength, power, and physical function, maximal ventilatory capacity, and aerobic endurance are being measured in the USC GCRC

    Despite Dr. Sattler's extensive research activities and multiple important administrative posts, he is highly committed to teaching at all levels. Whether guiding a clinical fellow through logical decision-making in a complex case, or mentoring students, postdoctoral fellows, or junior faculty, he remains thoroughly accessible, insightful, and compassionate, while ceaselessly energetic.

    Collapse Research 
    Collapse Research Activities and Funding
    Phase II trial of tesamorelin for cognition in aging HIV-infected persons
    NIH/NIA R01AG048650Sep 30, 2015 - May 31, 2020
    Role: Co-Principal Investigator
    NIH/NIAID UM1AI069428Jul 1, 2007 - Nov 30, 2014
    Role: Principal Investigator
    NIH/NIAID U01AI069428Jul 1, 2007 - Nov 30, 2013
    Role: Principal Investigator
    NIH/NIA R01AG018169Sep 1, 2002 - Aug 31, 2009
    Role: Principal Investigator
    NIH/NIDDK R01DK049308Sep 30, 1994 - Aug 31, 1999
    Role: Principal Investigator
    NIH/NIAID U01AI027673Jun 30, 1986 - Dec 31, 2006
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Dieli-Conwright CM, Parmentier JH, Sami N, Lee K, Spicer D, Mack WJ, Sattler F, Mittelman SD. Adipose tissue inflammation in breast cancer survivors: effects of a 16-week combined aerobic and resistance exercise training intervention. Breast Cancer Res Treat. 2018 Feb; 168(1):147-157. PMID: 29168064.
      View in: PubMed
    2. Lake JE, Stanley TL, Apovian CM, Bhasin S, Brown TT, Capeau J, Currier JS, Dube MP, Falutz J, Grinspoon SK, Guaraldi G, Martinez E, McComsey GA, Sattler F, Erlandson KM. Practical Review of Recognition and Management of Obesity and Lipohypertrophy in Human Immunodeficiency Virus Infection. Clin Infect Dis. 2017 May 15; 64(10):1422-1429. PMID: 28329372.
      View in: PubMed
    3. Dieli-Conwright CM, Kiwata JL, Tuzon CT, Spektor TM, Sattler F, Rice JC, Schroeder ET. Acute Response of PGC-1a and IGF-1 Isoforms to Maximal Eccentric Exercise in Skeletal Muscle of Postmenopausal Women. J Strength Cond Res. 2016 Apr; 30(4):1161-70. PMID: 26340467; PMCID: PMC4769997 [Available on 04/01/17].
    4. Luetkemeyer AF, Firnhaber C, Kendall MA, Wu X, Mazurek GH, Benator DA, Arduino R, Fernandez M, Guy E, Johnson P, Metchock B, Sattler F, Telzak E, Wang YF, Weiner M, Swindells S, Sanne IM, Havlir DV, Grinsztejn B, Alland D. Evaluation of Xpert MTB/RIF Versus AFB Smear and Culture to Identify Pulmonary Tuberculosis in Patients With Suspected Tuberculosis From Low and Higher Prevalence Settings. Clin Infect Dis. 2016 May 01; 62(9):1081-8. PMID: 26839383; PMCID: PMC4826450 [Available on 05/01/17].
    5. Sattler F, He J, Letendre S, Wilson C, Sanders C, Heaton R, Ellis R, Franklin D, Aldrovandi G, Marra CM, Clifford D, Morgello S, Grant I, McCutchan JA. Abdominal obesity contributes to neurocognitive impairment in HIV-infected patients with increased inflammation and immune activation. J Acquir Immune Defic Syndr. 2015 Mar 01; 68(3):281-8. PMID: 25469522.
      View in: PubMed
    6. Alderete TL, Sattler F, Richey JM, Allayee H, Mittelman SD, Sheng X, Tucci J, Gyllenhammer LE, Grant EG, Goran MI. Salsalate treatment improves glycemia without altering adipose tissue in nondiabetic obese hispanics. Obesity (Silver Spring). 2015 Mar; 23(3):543-51. PMID: 25644856; PMCID: PMC4340767.
    7. Grant PM, Komarow L, Sanchez A, Sattler F, Asmuth DM, Pollard RB, Zolopa AR. Clinical and immunologic predictors of death after an acute opportunistic infection: results from ACTG A5164. HIV Clin Trials. 2014 Jul-Aug; 15(4):133-9. PMID: 25143022; PMCID: PMC4167015.
    8. Sattler F, He J, Chukwuneke J, Kim H, Stewart Y, Colletti P, Yarasheski K, Buchanan T. Testosterone Supplementation Improves Carbohydrate and Lipid Metabolism in Some Older Men with Abdominal Obesity. J Gerontol Geriatr Res. 2014 Jun 07; 3(3):1000159. PMID: 25392748.
      View in: PubMed
    9. Sattler F. Growth hormone in the aging male. Best Pract Res Clin Endocrinol Metab. 2013 Aug; 27(4):541-55. PMID: 24054930; PMCID: PMC3940699.
    10. Dieli-Conwright CM, Spektor TM, Rice JC, Sattler F, Schroeder ET. Hormone therapy and maximal eccentric exercise alters myostatin-related gene expression in postmenopausal women. J Strength Cond Res. 2012 May; 26(5):1374-82. PMID: 22395277.
      View in: PubMed
    11. Sanchez A, Azen C, Jones B, Louie S, Sattler F. Relationship of Acute Phase Reactants and Fat Accumulation during Treatment for Tuberculosis. Tuberc Res Treat. 2011; 2011:346295. PMID: 22567264; PMCID: PMC3335474.
    12. Schroeder ET, He J, Yarasheski KE, Binder EF, Castaneda-Sceppa C, Bhasin S, Dieli-Conwright CM, Kawakubo M, Roubenoff R, Azen SP, Sattler F. Value of measuring muscle performance to assess changes in lean mass with testosterone and growth hormone supplementation. Eur J Appl Physiol. 2012 Mar; 112(3):1123-31. PMID: 21748366; PMCID: PMC3448487.
    13. Sattler F, Bhasin S, He J, Yarasheski KE, Binder EF, Schroeder ET, Castaneda-Sceppa C, Kawakubo M, Roubenoff R, Dunn M, Hahn C, Stewart Y, Martinez C, Azen SP. Durability of the effects of testosterone and growth hormone supplementation in older community-dwelling men: the HORMA Trial. Clin Endocrinol (Oxf). 2011 Jul; 75(1):103-11. PMID: 21521283; PMCID: PMC3529980.
    14. Krishnan S, Schouten JT, Jacobson DL, Benson CA, Collier AC, Koletar SL, Santana J, Sattler F, Mitsuyasu R. Incidence of non-AIDS-defining cancer in antiretroviral treatment-naïve subjects after antiretroviral treatment initiation: an ACTG longitudinal linked randomized trials analysis. Oncology. 2011; 80(1-2):42-9. PMID: 21606663; PMCID: PMC3121543.
    15. Yarasheski KE, Castaneda-Sceppa C, He J, Kawakubo M, Bhasin S, Binder EF, Schroeder ET, Roubenoff R, Azen SP, Sattler F. Whole-body and muscle protein metabolism are not affected by acute deviations from habitual protein intake in older men: the Hormonal Regulators of Muscle and Metabolism in Aging (HORMA) Study. Am J Clin Nutr. 2011 Jul; 94(1):172-81. PMID: 21543538; PMCID: PMC3127526.
    16. Sattler F, Bhasin S, He J, Chou CP, Castaneda-Sceppa C, Yarasheski K, Binder E, Schroeder ET, Kawakubo M, Zhang A, Roubenoff R, Azen S. Testosterone threshold levels and lean tissue mass targets needed to enhance skeletal muscle strength and function: the HORMA trial. J Gerontol A Biol Sci Med Sci. 2011 Jan; 66(1):122-9. PMID: 21059836; PMCID: PMC3032430.
    17. Beringer PM, Owens H, Nguyen A, Mordwinkin N, Louie S, Mak M, Sattler F. Estimation of glomerular filtration rate by using serum cystatin C and serum creatinine concentrations in patients with human immunodeficiency virus. Pharmacotherapy. 2010 Oct; 30(10):1004-10. PMID: 20874037.
      View in: PubMed
    18. Dubé MP, Sattler F. Inflammation and complications of HIV disease. J Infect Dis. 2010 Jun 15; 201(12):1783-5. PMID: 20446849.
      View in: PubMed
    19. Dieli-Conwright CM, Spektor TM, Rice JC, Sattler F, Schroeder ET. Hormone replacement therapy and messenger RNA expression of estrogen receptor coregulators after exercise in postmenopausal women. Med Sci Sports Exerc. 2010 Mar; 42(3):422-9. PMID: 20164697.
      View in: PubMed
    20. Jensky NE, Sims JK, Dieli-Conwright CM, Sattler F, Rice JC, Schroeder ET. Exercise does not influence myostatin and follistatin messenger RNA expression in young women. J Strength Cond Res. 2010 Feb; 24(2):522-30. PMID: 20124796; PMCID: PMC2818823.
    21. Bhasin S, He EJ, Kawakubo M, Schroeder ET, Yarasheski K, Opiteck GJ, Reicin A, Chen F, Lam R, Tsou JA, Castaneda-Sceppa C, Binder EF, Azen SP, Sattler F. N-terminal propeptide of type III procollagen as a biomarker of anabolic response to recombinant human GH and testosterone. J Clin Endocrinol Metab. 2009 Nov; 94(11):4224-33. PMID: 19837911; PMCID: PMC2775648.
    22. Dieli-Conwright CM, Spektor TM, Rice JC, Sattler F, Schroeder ET. Influence of hormone replacement therapy on eccentric exercise induced myogenic gene expression in postmenopausal women. J Appl Physiol (1985). 2009 Nov; 107(5):1381-8. PMID: 19696363; PMCID: PMC2777804.
    23. Sattler F, Castaneda-Sceppa C, Binder EF, Schroeder ET, Wang Y, Bhasin S, Kawakubo M, Stewart Y, Yarasheski KE, Ulloor J, Colletti P, Roubenoff R, Azen SP. Testosterone and growth hormone improve body composition and muscle performance in older men. J Clin Endocrinol Metab. 2009 Jun; 94(6):1991-2001. PMID: 19293261; PMCID: PMC2690426.
    24. Sattler F, Rajicic N, Mulligan K, Yarasheski KE, Koletar SL, Zolopa A, Alston Smith B, Zackin R, Bistrian B. Evaluation of high-protein supplementation in weight-stable HIV-positive subjects with a history of weight loss: a randomized, double-blind, multicenter trial. Am J Clin Nutr. 2008 Nov; 88(5):1313-21. PMID: 18996868.
      View in: PubMed
    25. Sattler F. Pathogenesis and treatment of lipodystrophy: what clinicians need to know. Top HIV Med. 2008 Oct-Nov; 16(4):127-33. PMID: 18838747.
      View in: PubMed
    26. Tebas P, Zhang J, Yarasheski K, Evans S, Fischl MA, Shevitz A, Feinberg J, Collier AC, Shikuma C, Brizz B, Sattler F. Switching to a protease inhibitor-containing, nucleoside-sparing regimen (lopinavir/ritonavir plus efavirenz) increases limb fat but raises serum lipid levels: results of a prospective randomized trial (AIDS clinical trial group 5125s). J Acquir Immune Defic Syndr. 2007 Jun 01; 45(2):193-200. PMID: 17527093; PMCID: PMC4441526.
    27. Schroeder ET, Wang Y, Castaneda-Sceppa C, Cloutier G, Vallejo AF, Kawakubo M, Jensky NE, Coomber S, Azen SP, Sattler F. Reliability of maximal voluntary muscle strength and power testing in older men. J Gerontol A Biol Sci Med Sci. 2007 May; 62(5):543-9. PMID: 17522360.
      View in: PubMed
    28. Fujita S, Rasmussen BB, Cadenas JG, Drummond MJ, Glynn EL, Sattler F, Volpi E. Aerobic exercise overcomes the age-related insulin resistance of muscle protein metabolism by improving endothelial function and Akt/mammalian target of rapamycin signaling. Diabetes. 2007 Jun; 56(6):1615-22. PMID: 17351147; PMCID: PMC2740742.
    29. Schroeder ET, Castaneda-Sceppa C, Wang Y, Binder EF, Kawakubo M, Stewart Y, Storer T, Roubenoff R, Bhasin S, Yarasheski KE, Sattler F, Azen SP. Hormonal regulators of muscle and metabolism in aging (HORMA): design and conduct of a complex, double masked multicenter trial. Clin Trials. 2007; 4(5):560-71. PMID: 17942471; PMCID: PMC4301418.
    30. Bhasin S, Parker RA, Sattler F, Haubrich R, Alston B, Umbleja T, Shikuma CM. Effects of testosterone supplementation on whole body and regional fat mass and distribution in human immunodeficiency virus-infected men with abdominal obesity. J Clin Endocrinol Metab. 2007 Mar; 92(3):1049-57. PMID: 17164307.
      View in: PubMed
    31. Mulligan K, Zackin R, Von Roenn JH, Chesney MA, Egorin MJ, Sattler F, Benson CA, Liu T, Umbleja T, Shriver S, Auchus RJ, Schambelan M. Testosterone supplementation of megestrol therapy does not enhance lean tissue accrual in men with human immunodeficiency virus-associated weight loss: a randomized, double-blind, placebo-controlled, multicenter trial. J Clin Endocrinol Metab. 2007 Feb; 92(2):563-70. PMID: 17090640.
      View in: PubMed
    32. Vallejo AF, Schroeder ET, Zheng L, Jensky NE, Sattler F. Cardiopulmonary responses to eccentric and concentric resistance exercise in older adults. Age Ageing. 2006 May; 35(3):291-7. PMID: 16638770.
      View in: PubMed
    33. Dreyer HC, Blanco CE, Sattler F, Schroeder ET, Wiswell RA. Satellite cell numbers in young and older men 24 hours after eccentric exercise. Muscle Nerve. 2006 Feb; 33(2):242-53. PMID: 16315322.
      View in: PubMed
    34. Schroeder ET, Vallejo AF, Zheng L, Stewart Y, Flores C, Nakao S, Martinez C, Sattler F. Six-week improvements in muscle mass and strength during androgen therapy in older men. J Gerontol A Biol Sci Med Sci. 2005 Dec; 60(12):1586-92. PMID: 16424293.
      View in: PubMed
    35. Storer TW, Woodhouse LJ, Sattler F, Singh AB, Schroeder ET, Beck K, Padero M, Mac P, Yarasheski KE, Geurts P, Willemsen A, Harms MK, Bhasin S. A randomized, placebo-controlled trial of nandrolone decanoate in human immunodeficiency virus-infected men with mild to moderate weight loss with recombinant human growth hormone as active reference treatment. J Clin Endocrinol Metab. 2005 Aug; 90(8):4474-82. PMID: 15914526.
      View in: PubMed
    36. Mulligan K, Zackin R, Clark RA, Alston-Smith B, Liu T, Sattler F, Delvers TB, Currier JS. Effect of nandrolone decanoate therapy on weight and lean body mass in HIV-infected women with weight loss: a randomized, double-blind, placebo-controlled, multicenter trial. Arch Intern Med. 2005 Mar 14; 165(5):578-85. PMID: 15767536.
      View in: PubMed
    37. Borucki MJ, Spritzler J, Asmuth DM, Gnann J, Hirsch MS, Nokta M, Aweeka F, Nadler PI, Sattler F, Alston B, Nevin TT, Owens S, Waterman K, Hubbard L, Caliendo A, Pollard RB. A phase II, double-masked, randomized, placebo-controlled evaluation of a human monoclonal anti-Cytomegalovirus antibody (MSL-109) in combination with standard therapy versus standard therapy alone in the treatment of AIDS patients with Cytomegalovirus retinitis. Antiviral Res. 2004 Nov; 64(2):103-11. PMID: 15498605.
      View in: PubMed
    38. Schroeder ET, Zheng L, Ong MD, Martinez C, Flores C, Stewart Y, Azen C, Sattler F. Effects of androgen therapy on adipose tissue and metabolism in older men. J Clin Endocrinol Metab. 2004 Oct; 89(10):4863-72. PMID: 15472177.
      View in: PubMed
    39. Young EM, Considine RV, Sattler F, Deeg MA, Buchanan TA, Degawa-Yamauchi M, Shankar S, Edmondson-Melançon H, Hernandez J, Dubé MP. Changes in thrombolytic and inflammatory markers after initiation of indinavir- or amprenavir-based antiretroviral therapy. Cardiovasc Toxicol. 2004; 4(2):179-86. PMID: 15371633.
      View in: PubMed
    40. Schroeder ET, Zheng L, Yarasheski KE, Qian D, Stewart Y, Flores C, Martinez C, Terk M, Sattler F. Treatment with oxandrolone and the durability of effects in older men. J Appl Physiol (1985). 2004 Mar; 96(3):1055-62. PMID: 14578370.
      View in: PubMed
    41. Sattler F. Body habitus changes related to lipodystrophy. Clin Infect Dis. 2003 Apr 01; 36(Suppl 2):S84-90. PMID: 12652376.
      View in: PubMed
    42. Schroeder ET, Terk M, Sattler F. Androgen therapy improves muscle mass and strength but not muscle quality: results from two studies. Am J Physiol Endocrinol Metab. 2003 Jul; 285(1):E16-24. PMID: 12637255.
      View in: PubMed
    43. Schroeder ET, Singh A, Bhasin S, Storer TW, Azen C, Davidson T, Martinez C, Sinha-Hikim I, Jaque SV, Terk M, Sattler F. Effects of an oral androgen on muscle and metabolism in older, community-dwelling men. Am J Physiol Endocrinol Metab. 2003 Jan; 284(1):E120-8. PMID: 12388137.
      View in: PubMed
    44. Sattler F, Schroeder ET, Dube MP, Jaque SV, Martinez C, Blanche PJ, Azen S, Krauss RM. Metabolic effects of nandrolone decanoate and resistance training in men with HIV. Am J Physiol Endocrinol Metab. 2002 Dec; 283(6):E1214-22. PMID: 12388173.
      View in: PubMed
    45. Stohl W, Cheema GS, Briggs WS, Xu D, Sosnovtseva S, Roschke V, Ferrara DE, Labat K, Sattler F, Pierangeli SS, Hilbert DM. B lymphocyte stimulator protein-associated increase in circulating autoantibody levels may require CD4+ T cells: lessons from HIV-infected patients. Clin Immunol. 2002 Aug; 104(2):115-22. PMID: 12165272.
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    46. Dubé MP, Qian D, Edmondson-Melançon H, Sattler F, Goodwin D, Martinez C, Williams V, Johnson D, Buchanan TA. Prospective, intensive study of metabolic changes associated with 48 weeks of amprenavir-based antiretroviral therapy. Clin Infect Dis. 2002 Aug 15; 35(4):475-81. PMID: 12145733.
      View in: PubMed