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Florence M Hofman, PhD

Title(s)Professor of Pathology
AddressHMR 2011 Zonal Ave
Health Sciences Campus
Los Angeles CA 90089-9092
Phone+1 323 442 1153
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    Dr. Hofman's field of expertise is angiogenesis and the blood-brain-barrier in human primary brain tumors and metastatic breast cancer to the brain. Her approach is to functionally characterize the tumor-associated brain endothelial cells because these cells are the target for anti-vascular therapy in cancer. Her laboratory uses both in vitro and in vivo systems to determine the mechanism(s) of chemoresistance. Once it is understood why these cells are resistant to standard of care drugs, they will identify agents which specifically disrupt the tumor vasculature, resulting in eliminating tumor growth.

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    Temozolomide Perillyl Alcohol Conjugate as Treatment for Recurrent Malignant Brain tumors
    NIH/NCI R41CA192419Jul 1, 2016 - Jun 30, 2017
    Role: Co-Principal Investigator
    TAT AND HIV ENCEPHALITIS
    NIH/NINDS R01NS033805Feb 1, 1995 - Jan 31, 1999
    Role: Principal Investigator
    HIV INFECTION OF BONE MARROW STROMAL CELLS
    NIH/NIAID R03AI030218Sep 30, 1990 - Aug 31, 1992
    Role: Principal Investigator
    AIDS RETINITIS-PATHOGENIC MECHANISMS
    NIH/NEI R01EY008144Aug 1, 1989 - Mar 31, 1998
    Role: Principal Investigator
    THE ROLE OF MACROPHAGES IN MULTIPLE SCLEROSIS
    NIH/NINDS R01NS021411Jan 1, 1985 - Jun 30, 1987
    Role: Principal Investigator
    ANTIGEN EXPRESSION ON FETAL AND MALIGNANT LEUKOCYTES
    NIH/NCI R23CA034313Apr 1, 1983 - Sep 30, 1986
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Developing a clinically relevant radiosensitizer for temozolomide-resistant gliomas. PLoS One. 2020; 15(9):e0238238. Minea RO, Duc TC, Swenson SD, Cho HY, Huang M, Hartman H, Hofman FM, Schönthal AH, Chen TC. PMID: 32881880.
      View in: PubMed   Mentions:    Fields:    
    2. NEO100 enables brain delivery of blood-brain barrier-impermeable therapeutics. Neuro Oncol. 2020 Sep 02. Wang W, Marín-Ramos NI, He H, Zeng S, Cho HY, Swenson SD, Zheng L, Epstein AL, Schönthal AH, Hofman FM, Chen L, Chen TC. PMID: 32877532.
      View in: PubMed   Mentions:    Fields:    
    3. MiR-18a inhibits BMP4 and HIF-1a Normalizing Brain Arteriovenous Malformations. Circ Res. 2020 Aug 05. Marín-Ramos NI, Thein TZ, Ghaghada KB, Chen TC, Giannotta SL, Hofman F. PMID: 32755283.
      View in: PubMed   Mentions:    Fields:    
    4. Intravenous delivery of microRNA-133b along with Argonaute-2 enhances spinal cord recovery following cervical contusion in mice. Spine J. 2020 Jul; 20(7):1138-1151. Danilov CA, Gu Y, Punj V, Wu Z, Steward O, Schönthal AH, Tahara SM, Hofman FM, Chen TC. PMID: 32145360.
      View in: PubMed   Mentions: 1     Fields:    
    5. Inhibition of motility by NEO100 through the calpain-1/RhoA pathway. J Neurosurg. 2019 Aug 16; 1-12. Marín-Ramos NI, Pérez-Hernández M, Tam A, Swenson SD, Cho HY, Thein TZ, Hofman FM, Chen TC. PMID: 31419797.
      View in: PubMed   Mentions: 1     Fields:    
    6. Efficient brain targeting and therapeutic intracranial activity of bortezomib through intranasal co-delivery with NEO100 in rodent glioblastoma models. J Neurosurg. 2019 Mar 15; 1-9. Wang W, Swenson S, Cho HY, Hofman FM, Schönthal AH, Chen TC. PMID: 30875688.
      View in: PubMed   Mentions:    Fields:    
    7. The Rolipram-Perillyl Alcohol Conjugate (NEO214) Is A Mediator of Cell Death through the Death Receptor Pathway. Mol Cancer Ther. 2019 03; 18(3):517-530. Cho HY, Thein TZ, Wang W, Swenson SD, Fayngor RA, Ou M, Marín-Ramos NI, Schönthal AH, Hofman FM, Chen TC. PMID: 30647121.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    8. Distribution of cancer stem cells in two human brain gliomas. Oncol Lett. 2019 Feb; 17(2):2123-2130. Peng L, Fu J, Wang W, Hofman FM, Chen TC, Chen L. PMID: 30719107.
      View in: PubMed   Mentions:
    9. NEO412: A temozolomide analog with transdermal activity in melanoma in vitro and in vivo. Oncotarget. 2018 Dec 11; 9(97):37026-37041. Swenson S, Silva-Hirschberg C, Wang W, Singh A, Hofman FM, Chen KL, Schönthal AH, Chen TC. PMID: 30651933.
      View in: PubMed   Mentions:    Fields:    
    10. NEO212, a conjugate of temozolomide and perillyl alcohol, blocks the endothelial-to-mesenchymal transition in tumor-associated brain endothelial cells in glioblastoma. Cancer Lett. 2019 02 01; 442:170-180. Marín-Ramos NI, Jhaveri N, Thein TZ, Fayngor RA, Chen TC, Hofman FM. PMID: 30392789.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    11. Rare Stochastic Expression of O6-Methylguanine- DNA Methyltransferase (MGMT) in MGMT-Negative Melanoma Cells Determines Immediate Emergence of Drug-Resistant Populations upon Treatment with Temozolomide In Vitro and In Vivo. Cancers (Basel). 2018 Sep 28; 10(10). Chen TC, Chan N, Minea RO, Hartman H, Hofman FM, Schönthal AH. PMID: 30274152.
      View in: PubMed   Mentions:
    12. Therapeutic Immunization against Glioblastoma. Int J Mol Sci. 2018 Aug 27; 19(9). Schijns VEJC, Pretto C, Strik AM, Gloudemans-Rijkers R, Deviller L, Pierre D, Chung J, Dandekar M, Carrillo JA, Kong XT, Fu BD, Hsu FPK, Hofman FM, Chen TC, Zidovetzki R, Bota DA, Stathopoulos A. PMID: 30150597.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    13. Phase II study of ERC1671 plus bevacizumab versus bevacizumab plus placebo in recurrent glioblastoma: interim results and correlations with CD4+ T-lymphocyte counts. CNS Oncol. 2018 07 01; 7(3):CNS22. Bota DA, Chung J, Dandekar M, Carrillo JA, Kong XT, Fu BD, Hsu FP, Schönthal AH, Hofman FM, Chen TC, Zidovetzki R, Pretto C, Strik A, Schijns VE, Stathopoulos A. PMID: 30157683.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsCTClinical Trials
    14. NEO212: sub-cytotoxic doses capable of inhibiting glioma stem cell invasion. Oncoscience. 2018 May; 5(5-6):148-149. Marín-Ramos NI, Hofman FM, Chen TC. PMID: 30035171.
      View in: PubMed   Mentions:
    15. NEO212 Inhibits Migration and Invasion of Glioma Stem Cells. Mol Cancer Ther. 2018 03; 17(3):625-637. Marín-Ramos NI, Thein TZ, Cho HY, Swenson SD, Wang W, Schönthal AH, Chen TC, Hofman FM. PMID: 29440289.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    16. Induction of Pro-Apoptotic Endoplasmic Reticulum Stress in Multiple Myeloma Cells by NEO214, Perillyl Alcohol Conjugated to Rolipram. Int J Mol Sci. 2018 Jan 17; 19(1). Chen TC, Chan N, Labib S, Yu J, Cho HY, Hofman FM, Schönthal AH. PMID: 29342125.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    17. A perillyl alcohol-conjugated analog of 3-bromopyruvate without cellular uptake dependency on monocarboxylate transporter 1 and with activity in 3-BP-resistant tumor cells. Cancer Lett. 2017 08 01; 400:161-174. Chen TC, Yu J, Nouri Nigjeh E, Wang W, Myint PT, Zandi E, Hofman FM, Schönthal AH. PMID: 28450161.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    18. Intratumoral delivery of bortezomib: impact on survival in an intracranial glioma tumor model. J Neurosurg. 2018 03; 128(3):695-700. Wang W, Cho HY, Rosenstein-Sisson R, Marín Ramos NI, Price R, Hurth K, Schönthal AH, Hofman FM, Chen TC. PMID: 28409734.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    19. Heterocellular Contacts with Mouse Brain Endothelial Cells Via Laminin and a6ß1 Integrin Sustain Subventricular Zone (SVZ) Stem/Progenitor Cells Properties. Front Cell Neurosci. 2016; 10:284. Rosa AI, Grade S, Santos SD, Bernardino L, Chen TC, Relvas J, Hofman FM, Agasse F. PMID: 28018177.
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    20. Monoamine oxidase A (MAO A) inhibitors decrease glioma progression. Oncotarget. 2016 Mar 22; 7(12):13842-53. Kushal S, Wang W, Vaikari VP, Kota R, Chen K, Yeh TS, Jhaveri N, Groshen SL, Olenyuk BZ, Chen TC, Hofman FM, Shih JC. PMID: 26871599.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    21. Breast Cancer MDA-MB-231 Cells Use Secreted Heat Shock Protein-90alpha (Hsp90a) to Survive a Hostile Hypoxic Environment. Sci Rep. 2016 Feb 05; 6:20605. Dong H, Zou M, Bhatia A, Jayaprakash P, Hofman F, Ying Q, Chen M, Woodley DT, Li W. PMID: 26846992.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    22. A novel drug conjugate, NEO212, targeting proneural and mesenchymal subtypes of patient-derived glioma cancer stem cells. Cancer Lett. 2016 Feb 28; 371(2):240-50. Jhaveri N, Agasse F, Armstrong D, Peng L, Commins D, Wang W, Rosenstein-Sisson R, Vaikari VP, Santiago SV, Santos T, Chen L, Schönthal AH, Chen TC, Hofman FM. PMID: 26683773.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    23. Nanoparticle biointerfacing by platelet membrane cloaking. Nature. 2015 Oct 01; 526(7571):118-21. Hu CM, Fang RH, Wang KC, Luk BT, Thamphiwatana S, Dehaini D, Nguyen P, Angsantikul P, Wen CH, Kroll AV, Carpenter C, Ramesh M, Qu V, Patel SH, Zhu J, Shi W, Hofman FM, Chen TC, Gao W, Zhang K, Chien S, Zhang L. PMID: 26374997.
      View in: PubMed   Mentions: 134     Fields:    Translation:HumansAnimalsCells
    24. Chemotherapeutic effect of a novel temozolomide analog on nasopharyngeal carcinoma in vitro and in vivo. J Biomed Sci. 2015 Aug 19; 22:71. Chen TC, Cho HY, Wang W, Wetzel SJ, Singh A, Nguyen J, Hofman FM, Schönthal AH. PMID: 26282951.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    25. First clinical results of a personalized immunotherapeutic vaccine against recurrent, incompletely resected, treatment-resistant glioblastoma multiforme (GBM) tumors, based on combined allo- and auto-immune tumor reactivity. Vaccine. 2015 May 28; 33(23):2690-6. Schijns VE, Pretto C, Devillers L, Pierre D, Hofman FM, Chen TC, Mespouille P, Hantos P, Glorieux P, Bota DA, Stathopoulos A. PMID: 25865468.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsPHPublic HealthCTClinical Trials
    26. Use of ERC-1671 Vaccine in a Patient with Recurrent Glioblastoma Multiforme after Progression during Bevacizumab Therapy: First Published Report. Perm J. 2015; 19(2):41-6. Bota DA, Alexandru-Abrams D, Pretto C, Hofman FM, Chen TC, Fu B, Carrillo JA, Schijns VE, Stathopoulos A. PMID: 25785641.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    27. Quinoline-based antimalarial drugs: a novel class of autophagy inhibitors. Neurosurg Focus. 2015 Mar; 38(3):E12. Golden EB, Cho HY, Hofman FM, Louie SG, Schönthal AH, Chen TC. PMID: 25727221.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    28. Effects of convection-enhanced delivery of bevacizumab on survival of glioma-bearing animals. Neurosurg Focus. 2015 Mar; 38(3):E8. Wang W, Sivakumar W, Torres S, Jhaveri N, Vaikari VP, Gong A, Howard A, Golden EB, Louie SG, Schönthal AH, Hofman FM, Chen TC. PMID: 25727230.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    29. Intravenous administration of retroviral replicating vector, Toca 511, demonstrates therapeutic efficacy in orthotopic immune-competent mouse glioma model. Hum Gene Ther. 2015 Feb; 26(2):82-93. Huang TT, Parab S, Burnett R, Diago O, Ostertag D, Hofman FM, Espinoza FL, Martin B, Ibañez CE, Kasahara N, Gruber HE, Pertschuk D, Jolly DJ, Robbins JM. PMID: 25419577.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    30. Tumor vasculature and glioma stem cells: Contributions to glioma progression. Cancer Lett. 2016 10 01; 380(2):545-51. Jhaveri N, Chen TC, Hofman FM. PMID: 25527451.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    31. A novel temozolomide analog, NEO212, with enhanced activity against MGMT-positive melanoma in vitro and in vivo. Cancer Lett. 2015 Mar 28; 358(2):144-151. Chen TC, Cho HY, Wang W, Nguyen J, Jhaveri N, Rosenstein-Sisson R, Hofman FM, Schönthal AH. PMID: 25524552.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    32. Chloroquine enhances temozolomide cytotoxicity in malignant gliomas by blocking autophagy. Neurosurg Focus. 2014 Dec; 37(6):E12. Golden EB, Cho HY, Jahanian A, Hofman FM, Louie SG, Schönthal AH, Chen TC. PMID: 25434381.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    33. Sequential administration of carbon nanotubes and near-infrared radiation for the treatment of gliomas. Front Oncol. 2014; 4:180. Santos T, Fang X, Chen MT, Wang W, Ferreira R, Jhaveri N, Gundersen M, Zhou C, Pagnini P, Hofman FM, Chen TC. PMID: 25077069.
      View in: PubMed   Mentions:
    34. NEO212, temozolomide conjugated to perillyl alcohol, is a novel drug for effective treatment of a broad range of temozolomide-resistant gliomas. Mol Cancer Ther. 2014 Aug; 13(8):2004-17. Cho HY, Wang W, Jhaveri N, Lee DJ, Sharma N, Dubeau L, Schönthal AH, Hofman FM, Chen TC. PMID: 24994771.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    35. Argonaute-2 promotes miR-18a entry in human brain endothelial cells. J Am Heart Assoc. 2014 May 16; 3(3):e000968. Ferreira R, Santos T, Amar A, Gong A, Chen TC, Tahara SM, Giannotta SL, Hofman FM. PMID: 24837588.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    36. A novel temozolomide-perillyl alcohol conjugate exhibits superior activity against breast cancer cells in vitro and intracranial triple-negative tumor growth in vivo. Mol Cancer Ther. 2014 May; 13(5):1181-93. Chen TC, Cho HY, Wang W, Barath M, Sharma N, Hofman FM, Schönthal AH. PMID: 24623736.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    37. A systematic review of inhaled intranasal therapy for central nervous system neoplasms: an emerging therapeutic option. J Neurooncol. 2014 Feb; 116(3):437-46. Peterson A, Bansal A, Hofman F, Chen TC, Zada G. PMID: 24398618.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    38. Immunohistochemistry. Curr Protoc Immunol. 2013 Nov 18; 103:21.4.1-21.4.26. Hofman FM, Taylor CR. PMID: 24510546.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    39. MicroRNA-18a improves human cerebral arteriovenous malformation endothelial cell function. Stroke. 2014 Jan; 45(1):293-7. Ferreira R, Santos T, Amar A, Tahara SM, Chen TC, Giannotta SL, Hofman FM. PMID: 24203843.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    40. Repositioning of Verrucosidin, a purported inhibitor of chaperone protein GRP78, as an inhibitor of mitochondrial electron transport chain complex I. PLoS One. 2013; 8(6):e65695. Thomas S, Sharma N, Gonzalez R, Pao PW, Hofman FM, Chen TC, Louie SG, Pirrung MC, Schönthal AH. PMID: 23755268.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    41. Perillyl alcohol for the treatment of temozolomide-resistant gliomas. Mol Cancer Ther. 2012 Nov; 11(11):2462-72. Cho HY, Wang W, Jhaveri N, Torres S, Tseng J, Leong MN, Lee DJ, Goldkorn A, Xu T, Petasis NA, Louie SG, Schönthal AH, Hofman FM, Chen TC. PMID: 22933703.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    42. Inhibition of autophagy and induction of breast cancer cell death by mefloquine, an antimalarial agent. Cancer Lett. 2012 Dec 30; 326(2):143-54. Sharma N, Thomas S, Golden EB, Hofman FM, Chen TC, Petasis NA, Schönthal AH, Louie SG. PMID: 22863539.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    43. Preferential killing of triple-negative breast cancer cells in vitro and in vivo when pharmacological aggravators of endoplasmic reticulum stress are combined with autophagy inhibitors. Cancer Lett. 2012 Dec 01; 325(1):63-71. Thomas S, Sharma N, Golden EB, Cho H, Agarwal P, Gaffney KJ, Petasis NA, Chen TC, Hofman FM, Louie SG, Schönthal AH. PMID: 22664238.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    44. Development of immune memory to glial brain tumors after tumor regression induced by immunotherapeutic Toll-like receptor 7/8 activation. Oncoimmunology. 2012 May 01; 1(3):298-305. Stathopoulos A, Pretto C, Devillers L, Pierre D, Hofman FM, Kruse C, Jadus M, Chen TC, Schijns VE. PMID: 22737605.
      View in: PubMed   Mentions:
    45. Exploring the Therapeutic Efficacy of Glioma Vaccines Based on Allo- and Syngeneic Antigens and Distinct Immunological Costimulation Activators. J Clin Cell Immunol. 2012; Suppl 5:004. Stathopoulos A, Pretto C, Devillers L, Pierre D, Hofman FM, Epstein AL, Farghadani H, Kruse CA, Jadus MR, Chen TC, Schijns VE. PMID: 24955288.
      View in: PubMed   Mentions:
    46. Noscapine inhibits tumor growth in TMZ-resistant gliomas. Cancer Lett. 2011 Dec 22; 312(2):245-52. Jhaveri N, Cho H, Torres S, Wang W, Schönthal AH, Petasis NA, Louie SG, Hofman FM, Chen TC. PMID: 21925789.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimals
    47. Thrombospondin-1 modulates the angiogenic phenotype of human cerebral arteriovenous malformation endothelial cells. Neurosurgery. 2011 May; 68(5):1342-53; discussion 1353. Stapleton CJ, Armstrong DL, Zidovetzki R, Liu CY, Giannotta SL, Hofman FM. PMID: 21307796.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    48. A critical role for GRP78/BiP in the tumor microenvironment for neovascularization during tumor growth and metastasis. Cancer Res. 2011 Apr 15; 71(8):2848-57. Dong D, Stapleton C, Luo B, Xiong S, Ye W, Zhang Y, Jhaveri N, Zhu G, Ye R, Liu Z, Bruhn KW, Craft N, Groshen S, Hofman FM, Lee AS. PMID: 21467168.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    49. Green tea epigallocatechin gallate enhances therapeutic efficacy of temozolomide in orthotopic mouse glioblastoma models. Cancer Lett. 2011 Mar 28; 302(2):100-8. Chen TC, Wang W, Golden EB, Thomas S, Sivakumar W, Hofman FM, Louie SG, Schönthal AH. PMID: 21257259.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    50. Preclinical development of novel anti-glioma drugs targeting the endoplasmic reticulum stress response. Curr Pharm Des. 2011; 17(23):2428-38. Schönthal AH, Chen TC, Hofman FM, Louie SG, Petasis NA. PMID: 21827419.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    51. Immunotherapy of malignant gliomas using autologous and allogeneic tissue cells. Anticancer Agents Med Chem. 2010 Jul; 10(6):462-70. Hofman FM, Stathopoulos A, Kruse CA, Chen TC, Schijns VE. PMID: 20879986.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    52. Effective conversion of irinotecan to SN-38 after intratumoral drug delivery to an intracranial murine glioma model in vivo. Laboratory investigation. J Neurosurg. 2011 Mar; 114(3):689-94. Wang W, Ghandi A, Liebes L, Louie SG, Hofman FM, Schönthal AH, Chen TC. PMID: 20415520.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    53. Antiangiogenic activities of 2,5-dimethyl-celecoxib on the tumor vasculature. Mol Cancer Ther. 2010 Mar; 9(3):631-41. Virrey JJ, Liu Z, Cho HY, Kardosh A, Golden EB, Louie SG, Gaffney KJ, Petasis NA, Schönthal AH, Chen TC, Hofman FM. PMID: 20197398.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    54. Glioma-associated endothelial cells are chemoresistant to temozolomide. J Neurooncol. 2009 Oct; 95(1):13-22. Virrey JJ, Golden EB, Sivakumar W, Wang W, Pen L, Schönthal AH, Hofman FM, Chen TC. PMID: 19381445.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    55. Enhanced killing of chemo-resistant breast cancer cells via controlled aggravation of ER stress. Cancer Lett. 2009 Sep 08; 282(1):87-97. Cho HY, Thomas S, Golden EB, Gaffney KJ, Hofman FM, Chen TC, Louie SG, Petasis NA, Schönthal AH. PMID: 19345476.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    56. Optic neuritis in different strains of mice by a recombinant HSV-1 expressing murine interleukin-2. Invest Ophthalmol Vis Sci. 2009 Jul; 50(7):3275-82. Zandian M, Belisle R, Mott KR, Nusinowitz S, Hofman FM, Ghiasi H. PMID: 19234357.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    57. Aberrant angiogenic characteristics of human brain arteriovenous malformation endothelial cells. Neurosurgery. 2009 Jan; 64(1):139-46; discussion 146-8. Jabbour MN, Elder JB, Samuelson CG, Khashabi S, Hofman FM, Giannotta SL, Liu CY. PMID: 19145162.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    58. Stress chaperone GRP78/BiP confers chemoresistance to tumor-associated endothelial cells. Mol Cancer Res. 2008 Aug; 6(8):1268-75. Virrey JJ, Dong D, Stiles C, Patterson JB, Pen L, Ni M, Schönthal AH, Chen TC, Hofman FM, Lee AS. PMID: 18708359.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    59. Increased survivin expression confers chemoresistance to tumor-associated endothelial cells. Am J Pathol. 2008 Aug; 173(2):575-85. Virrey JJ, Guan S, Li W, Schönthal AH, Chen TC, Hofman FM. PMID: 18599610.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    60. Aggravated endoplasmic reticulum stress as a basis for enhanced glioblastoma cell killing by bortezomib in combination with celecoxib or its non-coxib analogue, 2,5-dimethyl-celecoxib. Cancer Res. 2008 Feb 01; 68(3):843-51. Kardosh A, Golden EB, Pyrko P, Uddin J, Hofman FM, Chen TC, Louie SG, Petasis NA, Schönthal AH. PMID: 18245486.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    61. Celecoxib analogs that lack COX-2 inhibitory function: preclinical development of novel anticancer drugs. Expert Opin Investig Drugs. 2008 Feb; 17(2):197-208. Schönthal AH, Chen TC, Hofman FM, Louie SG, Petasis NA. PMID: 18230053.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    62. Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development. Cancer Res. 2008 Jan 15; 68(2):498-505. Dong D, Ni M, Li J, Xiong S, Ye W, Virrey JJ, Mao C, Ye R, Wang M, Pen L, Dubeau L, Groshen S, Hofman FM, Lee AS. PMID: 18199545.
      View in: PubMed   Mentions: 148     Fields:    Translation:Animals
    63. The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas. Cancer Res. 2007 Oct 15; 67(20):9809-16. Pyrko P, Schönthal AH, Hofman FM, Chen TC, Lee AS. PMID: 17942911.
      View in: PubMed   Mentions: 149     Fields:    Translation:HumansCells
    64. Reduced survivin expression and tumor cell survival during chronic hypoxia and further cytotoxic enhancement by the cyclooxygenase-2 inhibitor celecoxib. J Biomed Sci. 2007 Sep; 14(5):647-62. Kardosh A, Soriano N, Pyrko P, Liu YT, Jabbour M, Hofman FM, Schönthal AH. PMID: 17440835.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    65. Both virus and tumor necrosis factor alpha are critical for endothelium damage in a mouse model of dengue virus-induced hemorrhage. J Virol. 2007 Jun; 81(11):5518-26. Chen HC, Hofman FM, Kung JT, Lin YD, Wu-Hsieh BA. PMID: 17360740.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    66. Irinotecan: a potential new chemotherapeutic agent for atypical or malignant meningiomas. J Neurosurg. 2007 Mar; 106(3):455-62. Gupta V, Su YS, Samuelson CG, Liebes LF, Chamberlain MC, Hofman FM, Schönthal AH, Chen TC. PMID: 17367069.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    67. Mycobacteria-induced Gr-1+ subsets from distinct myeloid lineages have opposite effects on T cell expansion. J Leukoc Biol. 2007 May; 81(5):1205-12. Dietlin TA, Hofman FM, Lund BT, Gilmore W, Stohlman SA, van der Veen RC. PMID: 17307863.
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    68. Glioma-associated endothelial cells show evidence of replicative senescence. Exp Cell Res. 2007 Apr 01; 313(6):1192-202. Charalambous C, Virrey J, Kardosh A, Jabbour MN, Qazi-Abdullah L, Pen L, Zidovetzki R, Schönthal AH, Chen TC, Hofman FM. PMID: 17291495.
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    69. Downregulation of survivin expression and concomitant induction of apoptosis by celecoxib and its non-cyclooxygenase-2-inhibitory analog, dimethyl-celecoxib (DMC), in tumor cells in vitro and in vivo. Mol Cancer. 2006 May 18; 5:19. Pyrko P, Soriano N, Kardosh A, Liu YT, Uddin J, Petasis NA, Hofman FM, Chen CS, Chen TC, Schönthal AH. PMID: 16707021.
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    70. Enhancement of glioblastoma cell killing by combination treatment with temozolomide and tamoxifen or hypericin. Neurosurg Focus. 2006 Apr 15; 20(4):E20. Gupta V, Su YS, Wang W, Kardosh A, Liebes LF, Hofman FM, Schönthal AH, Chen TC. PMID: 16709026.
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    71. Fibroblast growth factor-2-retargeted adenoviral vector for selective transduction of primary glioblastoma multiforme endothelial cells. Neurosurg Focus. 2006 Apr 15; 20(4):E26. Gupta V, Wang W, Sosnowski BA, Hofman FM, Chen TC. PMID: 16709032.
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    72. Characteristics of tumor-associated endothelial cells derived from glioblastoma multiforme. Neurosurg Focus. 2006 Apr 15; 20(4):E22. Charalambous C, Chen TC, Hofman FM. PMID: 16709028.
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    73. Multiple signaling pathways are involved in endothelin-1-induced brain endothelial cell migration. Am J Physiol Cell Physiol. 2006 Jul; 291(1):C155-64. Milan J, Charalambous C, Elhag R, Chen TC, Li W, Guan S, Hofman FM, Zidovetzki R. PMID: 16452160.
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    74. Interleukin-8 differentially regulates migration of tumor-associated and normal human brain endothelial cells. Cancer Res. 2005 Nov 15; 65(22):10347-54. Charalambous C, Pen LB, Su YS, Milan J, Chen TC, Hofman FM. PMID: 16288024.
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    75. Multitarget inhibition of drug-resistant multiple myeloma cell lines by dimethyl-celecoxib (DMC), a non-COX-2 inhibitory analog of celecoxib. Blood. 2005 Dec 15; 106(13):4330-8. Kardosh A, Soriano N, Liu YT, Uddin J, Petasis NA, Hofman FM, Chen TC, Schönthal AH. PMID: 16123214.
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    76. Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease. Nat Med. 2005 Sep; 11(9):959-65. Wu Z, Guo H, Chow N, Sallstrom J, Bell RD, Deane R, Brooks AI, Kanagala S, Rubio A, Sagare A, Liu D, Li F, Armstrong D, Gasiewicz T, Zidovetzki R, Song X, Hofman F, Zlokovic BV. PMID: 16116430.
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    77. T cell expansion is regulated by activated Gr-1+ splenocytes. Cell Immunol. 2005 May; 235(1):39-45. Dietlin TA, Hofman FM, Gilmore W, Stohlman SA, van der Veen RC. PMID: 16083869.
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    78. Dimethyl-celecoxib (DMC), a derivative of celecoxib that lacks cyclooxygenase-2-inhibitory function, potently mimics the anti-tumor effects of celecoxib on Burkitt's lymphoma in vitro and in vivo. Cancer Biol Ther. 2005 May; 4(5):571-82. Kardosh A, Wang W, Uddin J, Petasis NA, Hofman FM, Chen TC, Schönthal AH. PMID: 15846081.
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    79. CD8+-dependent CNS demyelination following ocular infection of mice with a recombinant HSV-1 expressing murine IL-2. Exp Neurol. 2005 May; 193(1):1-18. Osorio Y, La Point SF, Nusinowitz S, Hofman FM, Ghiasi H. PMID: 15817260.
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    80. Functional and phenotypic differences between glioblastoma multiforme-derived and normal human brain endothelial cells. J Neurosurg. 2005 Apr; 102(4):699-705. Charalambous C, Hofman FM, Chen TC. PMID: 15871513.
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    81. Extra-cellular superoxide promotes T cell expansion through inactivation of nitric oxide. J Neuroimmunol. 2004 Aug; 153(1-2):183-9. van der Veen RC, Dietlin TA, Karapetian A, Holland SM, Hofman FM. PMID: 15265676.
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    82. Involvement of CD8+ T-cells in exacerbation of corneal scarring in mice. Curr Eye Res. 2004 Aug-Sep; 29(2-3):145-51. Osorio Y, Cai S, Hofman FM, Brown DJ, Ghiasi H. PMID: 15512961.
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    83. Tissue expression of inducible nitric oxide synthase requires IFN-gamma production by infiltrating splenic T cells: more evidence for immunosuppression by nitric oxide. J Neuroimmunol. 2003 Dec; 145(1-2):86-90. van der Veen RC, Dietlin TA, Hofman FM. PMID: 14644034.
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    84. A simple method for isolation and characterization of mouse brain microvascular endothelial cells. J Neurosci Methods. 2003 Nov 30; 130(1):53-63. Wu Z, Hofman FM, Zlokovic BV. PMID: 14583404.
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    85. RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain. Nat Med. 2003 Jul; 9(7):907-13. Deane R, Du Yan S, Submamaryan RK, LaRue B, Jovanovic S, Hogg E, Welch D, Manness L, Lin C, Yu J, Zhu H, Ghiso J, Frangione B, Stern A, Schmidt AM, Armstrong DL, Arnold B, Liliensiek B, Nawroth P, Hofman F, Kindy M, Stern D, Zlokovic B. PMID: 12808450.
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    86. Effect of endothelial cell polarity on beta-amyloid-induced migration of monocytes across normal and AD endothelium. Am J Physiol Cell Physiol. 2002 Sep; 283(3):C895-904. Giri R, Selvaraj S, Miller CA, Hofman F, Yan SD, Stern D, Zlokovic BV, Kalra VK. PMID: 12176746.
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    87. Immunohistochemistry. Curr Protoc Immunol. 2002 Aug; Chapter 21:Unit 21.4. Hofman F. PMID: 18432882.
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    88. The type IV phosphodiesterase inhibitor rolipram induces expression of the cell cycle inhibitors p21(Cip1) and p27(Kip1), resulting in growth inhibition, increased differentiation, and subsequent apoptosis of malignant A-172 glioma cells. Cancer Biol Ther. 2002 May-Jun; 1(3):268-76. Chen TC, Wadsten P, Su S, Rawlinson N, Hofman FM, Hill CK, Schönthal AH. PMID: 12432276.
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    89. Cell cycle phase-specific survival of CD95 ligand-challenged Jurkat cells: upregulation of heat-shock response. Cell Immunol. 2001 Jul 10; 211(1):21-9. Parr TB, Hofman FM, Kiener PA, Stohl W. PMID: 11585384.
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    90. Endothelin-1 and monocyte chemoattractant protein-1 modulation in ischemia and human brain-derived endothelial cell cultures. J Neuroimmunol. 2001 May 01; 116(1):62-73. Chen P, Shibata M, Zidovetzki R, Fisher M, Zlokovic BV, Hofman FM. PMID: 11311331.
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    91. Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke. Circulation. 2001 Apr 03; 103(13):1799-805. Shibata M, Kumar SR, Amar A, Fernandez JA, Hofman F, Griffin JH, Zlokovic BV. PMID: 11282913.
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    92. Antigen presentation to Th1 but not Th2 cells by macrophages results in nitric oxide production and inhibition of T cell proliferation: interferon-gamma is essential but insufficient. Cell Immunol. 2000 Dec 15; 206(2):125-35. van der Veen RC, Dietlin TA, Pen L, Gray JD, Hofman FM. PMID: 11161444.
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    93. Corneal macrophage infiltrates following ocular herpes simplex virus type 1 challenge vary in BALB/c mice vaccinated with different vaccines. Vaccine. 2000 Dec 08; 19(9-10):1266-73. Ghiasi H, Hofman FM, Wallner K, Cai S, Perng G, Nesburn AB, Wechsler SL. PMID: 11137266.
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    94. Superoxide prevents nitric oxide-mediated suppression of helper T lymphocytes: decreased autoimmune encephalomyelitis in nicotinamide adenine dinucleotide phosphate oxidase knockout mice. J Immunol. 2000 May 15; 164(10):5177-83. van der Veen RC, Dietlin TA, Hofman FM, Pen L, Segal BH, Holland SM. PMID: 10799876.
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    95. Virus-induced neuronal apoptosis blocked by the herpes simplex virus latency-associated transcript. Science. 2000 Feb 25; 287(5457):1500-3. Perng GC, Jones C, Ciacci-Zanella J, Stone M, Henderson G, Yukht A, Slanina SM, Hofman FM, Ghiasi H, Nesburn AB, Wechsler SL. PMID: 10688801.
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    96. Endothelin-1-induced interleukin-8 production in human brain-derived endothelial cells is mediated by the protein kinase C and protein tyrosine kinase pathways. Blood. 1999 Aug 15; 94(4):1291-9. Zidovetzki R, Chen P, Chen M, Hofman FM. PMID: 10438717.
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    97. Endothelin-1 enhances plasminogen activator inhibitor-1 production by human brain endothelial cells via protein kinase C-dependent pathway. Arterioscler Thromb Vasc Biol. 1999 Jul; 19(7):1768-75. Zidovetzki R, Wang JL, Kim JA, Chen P, Fisher M, Hofman FM. PMID: 10397697.
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    98. Specific and nonspecific immune stimulation of MHC-II-deficient mice results in chronic HSV-1 infection of the trigeminal ganglia following ocular challenge. Virology. 1999 Jun 05; 258(2):208-16. Ghiasi H, Perng GC, Hofman FM, Cai S, Nesburn AB, Wechsler SL, Pemg GC. PMID: 10366558.
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    99. Vaccination with different HSV-1 glycoproteins induces different patterns of ocular cytokine responses following HSV-1 challenge of vaccinated mice. Vaccine. 1999 Jun 04; 17(20-21):2576-82. Ghiasi H, Hofman FM, Cai S, Perng GC, Nesburn AB, Wechsler SL. PMID: 10418905.
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    100. Nicotine increases plasminogen activator inhibitor-1 production by human brain endothelial cells via protein kinase C-associated pathway. Stroke. 1999 Mar; 30(3):651-5. Zidovetzki R, Chen P, Fisher M, Hofman FM, Faraci FM. PMID: 10066866.
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    101. HIV-1 tat protein induces the production of interleukin-8 by human brain-derived endothelial cells. J Neuroimmunol. 1999 Feb 01; 94(1-2):28-39. Hofman FM, Chen P, Incardona F, Zidovetzki R, Hinton DR. PMID: 10376933.
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    102. Endothelin-1 induces production of the neutrophil chemotactic factor interleukin-8 by human brain-derived endothelial cells. Blood. 1998 Nov 01; 92(9):3064-72. Hofman FM, Chen P, Jeyaseelan R, Incardona F, Fisher M, Zidovetzki R. PMID: 9787140.
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    103. The role of neutralizing antibody and T-helper subtypes in protection and pathogenesis of vaccinated mice following ocular HSV-1 challenge. Immunology. 1998 Nov; 95(3):352-9. Ghiasi H, Wechsler SL, Cai S, Nesburn AB, Hofman FM. PMID: 9824497.
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    104. Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways. AIDS Res Hum Retroviruses. 1998 Jul 01; 14(10):825-33. Zidovetzki R, Wang JL, Chen P, Jeyaseelan R, Hofman F. PMID: 9671211.
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    105. Up-regulation of the cAMP/PKA pathway inhibits proliferation, induces differentiation, and leads to apoptosis in malignant gliomas. Lab Invest. 1998 Feb; 78(2):165-74. Chen TC, Hinton DR, Zidovetzki R, Hofman FM. PMID: 9484714.
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    106. Circulating antibody against tumor necrosis factor-alpha protects rat brain from reperfusion injury. J Cereb Blood Flow Metab. 1998 Jan; 18(1):52-8. Lavine SD, Hofman FM, Zlokovic BV. PMID: 9428305.
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    107. Nonspecific interstitial pneumonitis mimicking Pneumocystis carinii pneumonia. Am J Respir Crit Care Med. 1997 Sep; 156(3 Pt 1):912-7. Sattler F, Nichols L, Hirano L, Hiti A, Hofman F, Hughlett C, Zeng L, Boylen CT, Koss M. PMID: 9310013.
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    108. Extensive peroxynitrite activity during progressive stages of central nervous system inflammation. J Neuroimmunol. 1997 Jul; 77(1):1-7. van der Veen RC, Hinton DR, Incardonna F, Hofman FM. PMID: 9209262.
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    109. Soluble TNF-alpha receptors are constitutively shed and downregulate adhesion molecule expression in malignant gliomas. J Neuropathol Exp Neurol. 1997 May; 56(5):541-50. Chen TC, Hinton DR, Sippy BD, Hofman FM. PMID: 9143267.
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    110. TGF-B2 and soluble p55 TNFR modulate VCAM-1 expression in glioma cells and brain derived endothelial cells. J Neuroimmunol. 1997 Mar; 73(1-2):155-61. Chen TC, Hinton DR, Yong VW, Hofman FM. PMID: 9058771.
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    111. Effects of tumor necrosis factor-alpha and interleukin-6 on fluid-phase permeability and ammonia diffusion in CNS-derived endothelial cells. J Investig Med. 1996 Oct; 44(8):474-82. Duchini A, Govindarajan S, Santucci M, Zampi G, Hofman FM. PMID: 8952229.
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    112. Soluble tumor necrosis factor receptors are present in human vitreous and shed by retinal pigment epithelial cells. Exp Eye Res. 1996 Sep; 63(3):311-7. Sippy BD, Hofman FM, Wright AD, He S, Ryan SJ, Hinton DR. PMID: 8943704.
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    113. Human immunodeficiency virus type 1 infection of the heart in three infants with acquired immunodeficiency syndrome and sudden death. Pediatr Infect Dis J. 1996 Sep; 15(9):819-24. Kovacs A, Hinton DR, Wright D, Xu J, Li XL, Rasheed S, Hofman F. PMID: 8878228.
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    114. Absence of a prominent Th2 cytokine response in human tuberculosis. Infect Immun. 1996 Apr; 64(4):1351-6. Lin Y, Zhang M, Hofman FM, Gong J, Barnes PF. PMID: 8606100.
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    115. Induction of intercellular adhesion molecule-1 by tumor necrosis factor-alpha through the 55-kDa receptor is dependent on protein kinase C in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 1996 Mar; 37(4):597-606. Sippy BD, Hofman FM, Wright AD, Wang JL, Gopalakrishna R, Gundimeda U, He S, Ryan SJ, Hinton DR. PMID: 8595959.
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    116. Increased expression of tumor necrosis factor-alpha receptors in the brains of patients with AIDS. J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Dec 15; 10(5):511-21. Sippy BD, Hofman FM, Wallach D, Hinton DR. PMID: 8548330.
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    117. Tumor necrosis factor expression during mouse hepatitis virus-induced demyelinating encephalomyelitis. J Virol. 1995 Sep; 69(9):5898-903. Stohlman SA, Hinton DR, Cua D, Dimacali E, Sensintaffar J, Hofman FM, Tahara SM, Yao Q. PMID: 7637037.
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    118. Transgenic mice support replication of hepatitis delta virus RNA in multiple tissues, particularly in skeletal muscle. J Virol. 1995 Aug; 69(8):4880-7. Polo JM, Jeng KS, Lim B, Govindarajan S, Hofman F, Sangiorgi F, Lai MM. PMID: 7609056.
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    119. SV40-immortalized and primary cultured human retinal pigment epithelial cells share similar patterns of cytokine-receptor expression and cytokine responsiveness. Curr Eye Res. 1995 Jun; 14(6):495-503. Sippy BD, Hofman FM, He S, Osusky R, Sheu SJ, Walker SM, Ryan SJ, Hinton DR. PMID: 7545567.
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    120. Local expression of tumor necrosis factor alpha and interleukin-2 correlates with protection against corneal scarring after ocular challenge of vaccinated mice with herpes simplex virus type 1. J Virol. 1995 Jan; 69(1):334-40. Ghiasi H, Wechsler SL, Kaiwar R, Nesburn AB, Hofman FM. PMID: 7983727.
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    121. Cytokine expression in radiation-induced delayed cerebral injury. Neurosurgery. 1994 Nov; 35(5):822-9; discussion 829-30. Kureshi SA, Hofman FM, Schneider JH, Chin LS, Apuzzo ML, Hinton DR. PMID: 7838329.
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    122. Exogenous tat protein activates central nervous system-derived endothelial cells. J Neuroimmunol. 1994 Oct; 54(1-2):19-28. Hofman FM, Dohadwala MM, Wright AD, Hinton DR, Walker SM. PMID: 7523444.
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    123. Recombination between feline exogenous and endogenous retroviral sequences generates tropism for cerebral endothelial cells. Am J Pathol. 1994 Feb; 144(2):348-58. Chakrabarti R, Hofman FM, Pandey R, Mathes LE, Roy-Burman P. PMID: 8311118.
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    124. Hypothesis for autoantigen presentation and T cell activation. Adv Exp Med Biol. 1994; 350:651-4. Mircheff AK, Gierow JP, Wood RL, Akashi RH, Hofman FM. PMID: 8030550.
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    125. Pathogenicity of a subgroup C feline leukemia virus (FeLV) is augmented when administered in association with certain FeLV recombinants. Virology. 1994 Jan; 198(1):185-95. Mathes LE, Pandey R, Chakrabarti R, Hofman FM, Hayes KA, Stromberg P, Roy-Burman P. PMID: 8259654.
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    126. Exogenous tat protein activates human endothelial cells. Blood. 1993 Nov 01; 82(9):2774-80. Hofman FM, Wright AD, Dohadwala MM, Wong-Staal F, Walker SM. PMID: 7693046.
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    127. Active specific immunotherapy of melanoma with allogeneic cell lysates. Rationale, results, and possible mechanisms of action. Ann N Y Acad Sci. 1993 Aug 12; 690:153-66. Mitchell MS, Harel W, Kan-Mitchell J, LeMay LG, Goedegebuure P, Huang XQ, Hofman F, Groshen S. PMID: 8368734.
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    128. Differential effects of tumor necrosis factor-alpha on proliferation, cell surface antigen expression, and cytokine interactions in malignant gliomas. Neurosurgery. 1993 Jan; 32(1):85-94. Chen TC, Hinton DR, Apuzzo ML, Hofman FM. PMID: 8093640.
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    129. Early activation of splenic macrophages by tumor necrosis factor alpha is important in determining the outcome of experimental histoplasmosis in mice. Infect Immun. 1992 Oct; 60(10):4230-8. Wu-Hsieh BA, Lee GS, Franco M, Hofman FM. PMID: 1398934.
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    130. Cytokines and immunoregulatory molecules in malignant glial neoplasms. J Neurosurg. 1992 Aug; 77(2):265-73. Schneider J, Hofman FM, Apuzzo ML, Hinton DR. PMID: 1625016.
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    131. Tumor necrosis factor-alpha in the retina in acquired immune deficiency syndrome. Invest Ophthalmol Vis Sci. 1992 May; 33(6):1829-35. Hofman FM, Hinton DR. PMID: 1582785.
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    132. Inflammatory leukocytes and cytokines in the peptide-induced disease of experimental allergic encephalomyelitis in SJL and B10.PL mice. Proc Natl Acad Sci U S A. 1992 Jan 15; 89(2):574-8. Merrill JE, Kono DH, Clayton J, Ando DG, Hinton DR, Hofman FM. PMID: 1370583.
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    133. Expression of adhesion molecules in leprosy lesions. Infect Immun. 1991 Nov; 59(11):4154-60. Sullivan L, Sano S, Pirmez C, Salgame P, Mueller C, Hofman F, Uyemura K, Rea TH, Bloom BR, Modlin RL. PMID: 1718871.
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    134. Regional distribution of thrombomodulin in human brain. Brain Res. 1991 Aug 09; 556(1):1-5. Wong VL, Hofman FM, Ishii H, Fisher M. PMID: 1657303.
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    135. Class II antigen expression by lacrimal epithelial cells. An updated working hypothesis for antigen presentation by epithelial cells. Invest Ophthalmol Vis Sci. 1991 Jul; 32(8):2302-10. Mircheff AK, Gierow JP, Lee LM, Lambert RW, Akashi RH, Hofman FM. PMID: 1830042.
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    136. Lymphokines and immunoregulatory molecules in subacute sclerosing panencephalitis. Clin Immunol Immunopathol. 1991 Mar; 58(3):331-42. Hofman FM, Hinton DR, Baemayr J, Weil M, Merrill JE. PMID: 1900461.
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    137. Differential CD3/T cell antigen receptor-mediated IL-2 production in jurkat T cells. Dissociation of IL-2 response from total inositol phosphate and calcium responses. J Immunol. 1990 Aug 15; 145(4):1078-87. Stohl W, Hofman FM, Gray JD. PMID: 2143206.
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    138. Cytokine interactions in the central nervous system. Reg Immunol. 1990-1991; 3(5):268-78. Hofman FM, Hinton DR. PMID: 1716950.
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    139. Tumor necrosis factor identified in multiple sclerosis brain. J Exp Med. 1989 Aug 01; 170(2):607-12. Hofman FM, Hinton DR, Johnson K, Merrill JE. PMID: 2754393.
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    140. An immunohistochemical study of the endolymphatic sac in patients with acoustic tumors. Laryngoscope. 1989 Aug; 99(8 Pt 1):775-8. Bui HT, Linthicum FH, Hofman FM, Bowman CA, House WF. PMID: 2755283.
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    141. Lymphocytes bearing antigen-specific gamma delta T-cell receptors accumulate in human infectious disease lesions. Nature. 1989 Jun 15; 339(6225):544-8. Modlin RL, Pirmez C, Hofman FM, Torigian V, Uyemura K, Rea TH, Bloom BR, Brenner MB. PMID: 2471938.
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    142. IL-4 regulates differentiation and proliferation of human precursor B cells. J Immunol. 1988 Aug 15; 141(4):1185-90. Hofman FM, Brock M, Taylor CR, Lyons B. PMID: 3260922.
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    143. Expression of Fc epsilon receptors and surface and cytoplasmic IgE on human fetal and adult lymphopoietic tissue. Clin Immunol Immunopathol. 1988 Aug; 48(2):214-24. Kanowith-Klein S, Hofman F, Saxon A. PMID: 2968873.
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    144. In situ identification of activated Ta1+ T lymphocytes in human leprosy skin lesions. Int J Lepr Other Mycobact Dis. 1987 Sep; 55(3):494-8. Shen JY, Hofman FM, Gunter JR, Modlin RL, Rea TH. PMID: 2443587.
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    145. Immunohistology of persistent generalized lymphadenopathy. Evidence for progressive lymph node abnormalities in some patients. Am J Clin Pathol. 1987 Jul; 88(1):10-9. Turner RR, Meyer PR, Taylor CR, Gill PS, Hofman FM, Nichols P, Rasheed S, Levine AM. PMID: 3300263.
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    146. Human endolymphatic sac: morphologic evidence of immunologic function. Ann Otol Rhinol Laryngol. 1987 May-Jun; 96(3 Pt 1):276-81. Wackym PA, Friberg U, Linthicum FH, Bagger-Sjöbäck D, Bui HT, Hofman F, Rask-Andersen H. PMID: 3300505.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    147. The differentiation antigens of macrophages in human fetal liver. Clin Immunol Immunopathol. 1986 Nov; 41(2):184-92. Bhoopat L, Taylor CR, Hofman FM. PMID: 3769222.
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    148. Immunoregulatory molecules and IL 2 receptors identified in multiple sclerosis brain. J Immunol. 1986 May 01; 136(9):3239-45. Hofman FM, von Hanwehr RI, Dinarello CA, Mizel SB, Hinton D, Merrill JE. PMID: 3082983.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    149. Distribution of cells bearing the Tac antigen during ontogeny of human lymphoid tissue. J Immunol. 1985 Jun; 134(6):3751-5. Hofman FM, Modlin RL, Bhoopat L, Taylor CR. PMID: 2985695.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    150. Primary central nervous system lymphoma in homosexual men. Clinical, immunologic, and pathologic features. Am J Med. 1985 May; 78(5):742-8. Gill PS, Levine AM, Meyer PR, Boswell WD, Burkes RL, Parker JW, Hofman FM, Dworsky RL, Lukes RJ. PMID: 3873174.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    151. B- and T-lymphocytes in Hodgkin's disease. An immunohistochemical study utilizing heterologous and monoclonal antibodies. Cancer. 1985 Feb 15; 55(4):728-37. Forni M, Hofman FM, Parker JW, Lukes RJ, Taylor CR. PMID: 3155642.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    152. In situ localization of T lymphocytes in disseminated coccidioidomycosis. J Infect Dis. 1985 Feb; 151(2):314-9. Modlin RL, Segal GP, Hofman FM, Walley MS, Johnson RH, Taylor CR, Rea TH. PMID: 3155781.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    153. Demonstration in situ of subsets of T-lymphocytes in sarcoidosis. Am J Dermatopathol. 1984 Oct; 6(5):423-7. Modlin RL, Hofman FM, Sharma OP, Gottlieb B, Taylor CR, Rea TH. PMID: 6239559.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    154. Heterogeneity of macrophage populations in human lymphoid tissue and peripheral blood. Cell Immunol. 1984 Oct 01; 88(1):61-74. Hofman FM, Lopez D, Husmann L, Meyer PR, Taylor CR. PMID: 6478515.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    155. Ontogeny of B cell markers in the human fetal liver. J Immunol. 1984 Sep; 133(3):1197-201. Hofman FM, Danilovs J, Husmann L, Taylor CR. PMID: 6430996.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    156. Proliferation of astroglia and oligodendroglia in response to human T cell-derived factors. Science. 1984 Jun 29; 224(4656):1428-30. Merrill JE, Kutsunai S, Mohlstrom C, Hofman F, Groopman J, Golde DW. PMID: 6610212.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    157. HLA-DR (Ia)-positive dendritic-like cells in human fetal nonlymphoid tissues. Transplantation. 1984 Jun; 37(6):590-4. Hofman FM, Danilovs JA, Taylor CR. PMID: 6587648.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    158. In situ identification of cells in human leprosy granulomas with monoclonal antibodies to interleukin 2 and its receptor. J Immunol. 1984 Jun; 132(6):3085-90. Modlin RL, Hofman FM, Horwitz DA, Husmann LA, Gillis S, Taylor CR, Rea TH. PMID: 6327818.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    159. Mononuclear lymphoid populations infiltrating the microenvironment of primary CNS tumors. Characterization of cell subsets with monoclonal antibodies. J Neurosurg. 1984 Jun; 60(6):1138-47. von Hanwehr RI, Hofman FM, Taylor CR, Apuzzo ML. PMID: 6374063.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    160. Mycosis fungoides/Sezary's syndrome progressing to immunoblastic sarcoma. A T-cell lymphoproliferation with both helper and suppressor phenotypes. Am J Clin Pathol. 1984 Feb; 81(2):249-57. Yanagihara ET, Parker JW, Meyer PR, Cain MJ, Hofman F, Lukes RJ. PMID: 6230003.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    161. A cytotoxic monoclonal antibody detecting a novel B cell membrane antigen expressed predominantly on cells bearing surface membrane immunoglobulin. Blood. 1984 Feb; 63(2):319-25. Jephthah J, Terasaki PI, Hofman F, Wolde-Marian W, Peter JB, Billing R. PMID: 6607081.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    162. Analysis of B-cell antigens in normal reactive lymphoid tissue using four B-cell monoclonal antibodies. Blood. 1983 Oct; 62(4):775-83. Hofman FM, Yanagihara E, Byrne B, Billing R, Baird S, Frisman D, Taylor CR. PMID: 6411151.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    163. Altered distribution of B and T lymphocytes in lymph-nodes from homosexual men with Kaposi's sarcoma. Lancet. 1983 Oct 01; 2(8353):768-71. Modlin RL, Hofman FM, Meyer PR, Vaccaro SA, Ammann AJ, Conant MA, Rea TH, Taylor CR. PMID: 6137604.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    164. T-lymphocyte subsets in lymph nodes from homosexual men. JAMA. 1983 Sep 09; 250(10):1302-5. Modlin RL, Meyer PR, Hofman FM, Mehlmauer M, Levy NB, Lukes RJ, Parker JW, Ammann AJ, Conant MA, Rea TH, Taylor CR. PMID: 6224027.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    165. Immunoperoxidase techniques applied to dermatopathology. J Cutan Pathol. 1983 Jun; 10(3):145-63. Taylor CR, Hofman FM, Modlin RL, Rea TH. PMID: 6345613.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    166. Kaposi's sarcoma in homosexual men: an immunohistochemical study. J Am Acad Dermatol. 1983 May; 8(5):620-7. Modlin RL, Hofman FM, Kempf RA, Taylor CR, Conant MA, Rea TH. PMID: 6408146.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    167. Demonstration of a subpopulation of Ia+ T-helper cells in mycosis fungoides and the Sézary syndrome. Am J Dermatopathol. 1983 Apr; 5(2):135-43. Hofman FM, Meyer PR, Yanagihara E, Modlin RL, Rea TH, Parker JW, Lukes RJ, Taylor CR. PMID: 6224436.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    168. A monoclonal antibody cross-reactive with human platelets, megakaryocytes, and common acute lymphocytic leukemia cells. Blood. 1983 Apr; 61(4):759-64. Deng CT, Terasaki PI, Iwaki Y, Hofman FM, Koeffler P, Cahan L, El Awar N, Billing R. PMID: 6187394.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    169. In situ demonstration of T lymphocyte subsets in granulomatous inflammation: leprosy, rhinoscleroma and sarcoidosis. Clin Exp Immunol. 1983 Mar; 51(3):430-8. Modlin RL, Hofman FM, Meyer PR, Sharma OP, Taylor CR, Rea TH. PMID: 6221839.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    170. T lymphocyte subsets in the skin lesions of patients with leprosy. J Am Acad Dermatol. 1983 Feb; 8(2):182-9. Modlin RL, Hofman FM, Taylor CR, Rea TH. PMID: 6219136.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    171. In situ characterization of T lymphocyte subsets in leprosy granulomas. Int J Lepr Other Mycobact Dis. 1982 Sep; 50(3):361-2. Modlin RL, Hofman FM, Taylor CR, Rea TH. PMID: 6982876.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    172. Expression of HLA-DR antigens in human fetal pancreas tissue. Diabetes. 1982 Aug; 31 Suppl 4:23-9. Danilovs JA, Hofman FM, Taylor CR, Brown J. PMID: 6762306.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    173. Cytoplasmic as opposed to surface Ia antigens expressed on human peripheral blood lymphocytes and monocytes. Clin Exp Immunol. 1982 Aug; 49(2):355-63. Hofman FM, Billing RJ, Parker JW, Taylor CR. PMID: 6181924.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    174. T cell chronic lymphocytic leukaemia with suppressor phenotype. Clin Exp Immunol. 1982 Aug; 49(2):401-9. Hofman FM, Smith D, Hocking W. PMID: 6215199.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    175. Stability of T- and B-cell numbers in human peripheral blood. Am J Clin Pathol. 1982 Jun; 77(6):710-3. Hofman FM, Kanesberg B, Smith D, Garrison D, Sevier ED. PMID: 6979921.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    176. Functional properties of subsets of T lymphocytes defined by specific antigens. Clin Exp Immunol. 1981 Jun; 44(3):476-84. Hofman F, Foon K, Smith D, Kransler J, Cicciarelli J, Billing R. PMID: 6459895.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    177. Adherent cell requirement for PWM-stimulated factor suppression of natural killer cytotoxicity. Cell Immunol. 1981 Mar 01; 58(2):356-65. Hofman F, Rand N, Fahey JL. PMID: 6452221.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    178. Enhancement of spontaneous killer cytotoxicity by soluble factor. Clin Exp Immunol. 1980 Dec; 42(3):589-96. Hofman FM, Spina CA. PMID: 6163580.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    179. Soluble suppressor factor produced by pokeweek mitogen-stimulated human peripheral blood leukocytes. Cell Immunol. 1980 Sep 15; 55(1):20-31. Hofman F, Spina CA, Rand N, Fahey JL. PMID: 6448693.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    180. Binding of F(ab')2 of normal human IgG to human lymphocytes. J Immunol. 1977 Dec; 119(6):2209-11. Hofman F, Cohen A, Zipori D, Burstein R, Benich Z, Haimovich J. PMID: 334987.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    181. Immunological potential of yolk sac cells. Adv Exp Med Biol. 1976; 66:51-7. Hofman F, Globerson A. PMID: 131474.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    182. Graft-versus-host reaction in F 1 recipients in the absence of donor (parental) cell proliferation. Eur J Immunol. 1974 Jul; 4(7):490-3. Scollay RG, Hofman F, Globerson A. PMID: 4153366.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
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