Eva Astrid Operskalski, PhD

Title(s)Associate Professor of Research Pediatrics
SchoolKeck School of Medicine of USC
Phone+1 323 865 1554
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    Dr. Operskalski is Director of Clinical Research at the MCA Center and has over 25 years experience co-directing or managing complex multi-center investigations of factors that influence HIV and hepatitis B and C disease occurrence and outcome. Since joining MCA she has coordinated the numerous clinical research studies carried out by the program, including studies of the Pediatric AIDS Clinical Trials Group (PACTG), which is now the International Maternal Pediatric Adolescent Center Trials (IMPAACT) Group, other NIH-funded studies, and MCA's own investigator-initiated studies. The studies include therapeutic trials for HIV and other infectious diseases, vaccine studies, and observational studies of long-term outcomes of disease and therapy. She has participated in the development of collaborative activities related to maternal child and adolescent infectious disease prevention and treatment, including successful grant proposals to the national Health Resources and Services Administration to expand MCA’s coordinated clinical services and access to research for women, infants, children, and youth. Dr. Operskalski's research focus has been the epidemiology of HIV, HCV, and other transfusion-transmitted infections; specifically, factors that influence progression from infection to disease (including the effect of interactions of HIV, HTLV, HBV, HCV, EBV, CMV on progression and transmission of each) and factors that influence transmission by blood transfusion, and heterosexual and household contact. She was Principal Investigator for a clinic-based HIV vaccine preparedness (VPS) pilot study, sponsored by the PACTG, to investigate whether network analysis can be used to establish clinic-based cohorts of adolescents for HIV vaccine preparedness activities and vaccine trials. The VPS brought together a multi-disciplinary team of investigators from the KSOM Departments of Pediatrics and Preventive Medicine, as well as from Johns Hopkins University School of Public Health, and the Desmond Tutu HIV Centre in Cape Town and the Perinatal HIV Research Unit in Johannesburg, South Africa. These investigators have extensive experience and expertise in public health, epidemiology, prevention, social network mapping, and clinical research.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kerzerho J, McIlvaine EJ, Anthony P, Mack WJ, Wang CH, Frederick T, Operskalski E, Chen Z, Al-Harthi L, Landay A, Young MA, Tien PC, Augenbraun M, Strickler HD, Akbari O, Golub ET, Sharp GB, Kovacs A. Impact of Hepatitis C Virus on the Circulating Levels of IL-7 in HIV-1 Coinfected Women. J Acquir Immune Defic Syndr. 2016 Feb 01; 71(2):172-80. PMID: 26761519; PMCID: PMC4712709 [Available on 02/01/17].
    2. Spencer LY, Christiansen S, Wang CH, Mack WJ, Young M, Strickler HD, Anastos K, Minkoff H, Cohen M, Geenblatt RM, Karim R, Operskalski E, Frederick T, Homans JD, Landay A, Kovacs A. Systemic Immune Activation and HIV Shedding in the Female Genital Tract. J Acquir Immune Defic Syndr. 2016 Feb 01; 71(2):155-62. PMID: 26334738; PMCID: PMC4712091 [Available on 02/01/17].
    3. Jackman RP, Deng X, Bolgiano D, Utter GH, Schechterly C, Lebedeva M, Operskalski E, Luban NL, Alter H, Busch MP, Slichter SJ, Norris PJ. Leukoreduction and ultraviolet treatment reduce both the magnitude and the duration of the HLA antibody response. Transfusion. 2014 Mar; 54(3):672-80. PMID: 23808544; PMCID: PMC3825847.
    4. Karim R, Mack WJ, Stiller T, Operskalski E, Frederick T, Landay A, Young MA, Tien PC, Augenbraun M, Strickler HD, Kovacs A. Association of HIV clinical disease progression with profiles of early immune activation: results from a cluster analysis approach. AIDS. 2013 Jun 01; 27(9):1473-81. PMID: 23945505; PMCID: PMC3949252.
    5. Wohl AR, Galvan FH, Carlos JA, Myers HF, Garland W, Witt MD, Cadden J, Operskalski E, Jordan W, George S. A comparison of MSM stigma, HIV stigma and depression in HIV-positive Latino and African American men who have sex with men (MSM). AIDS Behav. 2013 May; 17(4):1454-64. PMID: 23247362.
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    6. Operskalski EA. HHV-8, transfusion, and mortality. J Infect Dis. 2012 Nov 15; 206(10):1485-7. PMID: 22949305.
      View in: PubMed
    7. Frederick T, Homans J, Spencer L, Kramer F, Stek A, Operskalski E, Kovacs A. The effect of prenatal highly active antiretroviral therapy on the transmission of congenital and perinatal/early postnatal cytomegalovirus among HIV-infected and HIV-exposed infants. Clin Infect Dis. 2012 Sep; 55(6):877-84. PMID: 22675157.
      View in: PubMed
    8. Homans J, Christensen S, Stiller T, Wang CH, Mack W, Anastos K, Minkoff H, Young M, Greenblatt R, Cohen M, Strickler H, Karim R, Spencer LY, Operskalski E, Frederick T, Kovacs A. Permissive and protective factors associated with presence, level, and longitudinal pattern of cervicovaginal HIV shedding. J Acquir Immune Defic Syndr. 2012 May 01; 60(1):99-110. PMID: 22517416; PMCID: PMC3334315.
    9. Selvarajah S, Keating S, Heitman J, Lu K, Simmons G, Norris PJ, Operskalski E, Mosley JW, Busch MP. Detection of host immune responses in acute phase sera of spontaneous resolution versus persistent hepatitis C virus infection. J Gen Virol. 2012 Aug; 93(Pt 8):1673-9. PMID: 22535775; PMCID: PMC3541758.
    10. Wohl AR, Galvan FH, Myers HF, Garland W, George S, Witt M, Cadden J, Operskalski E, Jordan W, Carpio F, Lee ML. Do social support, stress, disclosure and stigma influence retention in HIV care for Latino and African American men who have sex with men and women? AIDS Behav. 2011 Aug; 15(6):1098-110. PMID: 20963630.
      View in: PubMed
    11. Operskalski EA, Kovacs A. HIV/HCV co-infection: pathogenesis, clinical complications, treatment, and new therapeutic technologies. Curr HIV/AIDS Rep. 2011 Mar; 8(1):12-22. PMID: 21221855; PMCID: PMC3035774.
    12. Bernardin F, Operskalski E, Busch M, Delwart E. Transfusion transmission of highly prevalent commensal human viruses. Transfusion. 2010 Nov; 50(11):2474-83. PMID: 20497515.
      View in: PubMed
    13. Wohl AR, Galvan FH, Myers HF, Garland W, George S, Witt M, Cadden J, Operskalski E, Jordan W, Carpio F. Social support, stress and social network characteristics among HIV-positive Latino and African American women and men who have sex with men. AIDS Behav. 2010 Oct; 14(5):1149-58. PMID: 20107888.
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    14. Kovacs A, Karim R, Mack WJ, Xu J, Chen Z, Operskalski E, Frederick T, Landay A, Voris J, Spencer LS, Young MA, Tien PC, Augenbraun M, Strickler HD, Al-Harthi L. Activation of CD8 T cells predicts progression of HIV infection in women coinfected with hepatitis C virus. J Infect Dis. 2010 Mar 15; 201(6):823-34. PMID: 20151840; PMCID: PMC3105602.
    15. Valente TW, Zogg JB, Christensen S, Richardson J, Kovacs A, Operskalski E. Using social networks to recruit an HIV vaccine preparedness cohort. J Acquir Immune Defic Syndr. 2009 Dec 01; 52(4):514-23. PMID: 19584741; PMCID: PMC2783777.
    16. French AL, Lin MY, Evans CT, Benning L, Glesby MJ, Young MA, Operskalski EA, Augenbraun M, Peters M. Long-term serologic follow-up of isolated hepatitis B core antibody in HIV-infected and HIV-uninfected women. Clin Infect Dis. 2009 Jul 01; 49(1):148-54. PMID: 19480573; PMCID: PMC2743413.
    17. Cannon MJ, Operskalski EA, Mosley JW, Radford K, Dollard SC. Lack of evidence for human herpesvirus-8 transmission via blood transfusion in a historical US cohort. J Infect Dis. 2009 Jun 01; 199(11):1592-8. PMID: 19385734.
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    18. Kapetanovic S, Christensen S, Karim R, Lin F, Mack WJ, Operskalski E, Frederick T, Spencer L, Stek A, Kramer F, Kovacs A. Correlates of perinatal depression in HIV-infected women. AIDS Patient Care STDS. 2009 Feb; 23(2):101-8. PMID: 19196032; PMCID: PMC2856494.
    19. Operskalski EA, Mack WJ, Strickler HD, French AL, Augenbraun M, Tien PC, Villacres MC, Spencer LY, Degiacomo M, Kovacs A. Factors associated with hepatitis C viremia in a large cohort of HIV-infected and -uninfected women. J Clin Virol. 2008 Apr; 41(4):255-63. PMID: 18243785; PMCID: PMC3493623.
    20. French AL, Operskalski E, Peters M, Strickler HD, Tien PC, Sharp GB, Glesby MJ, Young M, Augenbraun M, Seaberg E, Kovacs A. Isolated hepatitis B core antibody is associated with HIV and ongoing but not resolved hepatitis C virus infection in a cohort of US women. J Infect Dis. 2007 May 15; 195(10):1437-42. PMID: 17436223; PMCID: PMC3133731.
    21. Laskus T, Operskalski EA, Radkowski M, Wilkinson J, Mack WJ, deGiacomo M, Al-Harthi L, Chen Z, Xu J, Kovacs A. Negative-strand hepatitis C virus (HCV) RNA in peripheral blood mononuclear cells from anti-HCV-positive/HIV-infected women. J Infect Dis. 2007 Jan 01; 195(1):124-33. PMID: 17152016; PMCID: PMC3319123.
    22. Diaz RS, Pardini R, Catroxo M, Operskalski EA, Mosley JW, Busch MP. HIV-1 superinfection is not a common event. J Clin Virol. 2005 Aug; 33(4):328-30. PMID: 16036183.
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    23. Mosley JW, Operskalski EA, Tobler LH, Andrews WW, Phelps B, Dockter J, Giachetti C, Busch MP. Viral and host factors in early hepatitis C virus infection. Hepatology. 2005 Jul; 42(1):86-92. PMID: 15954090.
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    24. Laskus T, Wilkinson J, Gallegos-Orozco JF, Radkowski M, Adair DM, Nowicki M, Operskalski E, Buskell Z, Seeff LB, Vargas H, Rakela J. Analysis of hepatitis C virus quasispecies transmission and evolution in patients infected through blood transfusion. Gastroenterology. 2004 Sep; 127(3):764-76. PMID: 15362033.
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    25. Operskalski EA, Mosley JW, Tobler LH, Fiebig EW, Nowicki MJ, Mimms LT, Gallarda J, Phelps BH, Busch MP. HCV viral load in anti-HCV-reactive donors and infectivity for their recipients. Transfusion. 2003 Oct; 43(10):1433-41. PMID: 14507276.
      View in: PubMed
    26. Ioannidis JP, Rosenberg PS, Goedert JJ, Ashton LJ, Benfield TL, Buchbinder SP, Coutinho RA, Eugen-Olsen J, Gallart T, Katzenstein TL, Kostrikis LG, Kuipers H, Louie LG, Mallal SA, Margolick JB, Martinez OP, Meyer L, Michael NL, Operskalski E, Pantaleo G, Rizzardi GP, Schuitemaker H, Sheppard HW, Stewart GJ, Theodorou ID, Ullum H, Vicenzi E, Vlahov D, Wilkinson D, Workman C, Zagury JF, O'Brien TR. Effects of CCR5-Delta32, CCR2-64I, and SDF-1 3'A alleles on HIV-1 disease progression: An international meta-analysis of individual-patient data. Ann Intern Med. 2001 Nov 06; 135(9):782-95. PMID: 11694103.
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    27. Diaz RS, De Oliveira CF, Pardini R, Operskalski E, Mayer AJ, Busch MP. HIV type 1 tat gene heteroduplex mobility assay as a tool to establish epidemiologic relationships among HIV type 1-infected individuals. AIDS Res Hum Retroviruses. 1999 Sep 01; 15(13):1151-6. PMID: 10480628.
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    28. Kedes DH, Operskalski E, Busch M, Kohn R, Flood J, Ganem D. The seroepidemiology of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus): distribution of infection in KS risk groups and evidence for sexual transmission. Nat Med. 1996 Aug; 2(8):918-24. PMID: 8705863.
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