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Denise Al Alam, PhD

TitleAssistant Professor of Research Surgery
InstitutionUniversity of Southern California
DepartmentPediatrics
AddressCHLA 4650 W. Sunset Blvd.
Off Campus
Los Angeles CA 90026
Phone+1 323 361 7169
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Zhang Y, Yang Y, Jiang M, Huang SX, Zhang W, Al Alam D, Danopoulos S, Mori M, Chen YW, Balasubramanian R, Chuva de Sousa Lopes SM, Serra C, Bialecka M, Kim E, Lin S, Toste de Carvalho ALR, Riccio PN, Cardoso WV, Zhang X, Snoeck HW, Que J. 3D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling. Cell Stem Cell. 2018 Sep 13. PMID: 30244870.
      View in: PubMed
    2. Bower DV, Lansdale N, Navarro S, Truong TV, Bower DJ, Featherstone NC, Connell MG, Al Alam D, Frey MR, Trinh LA, Fernandez GE, Warburton D, Fraser SE, Bennett D, Jesudason EC. SERCA directs cell migration and branching across species and germ layers. Biol Open. 2017 Oct 15; 6(10):1458-1471. PMID: 28821490.
      View in: PubMed
    3. El-Hashash AH, Turcatel G, Al Alam D, Buckley S, Tokumitsu H, Bellusci S, Warburton D. Retraction: Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium. Development doi: 10.1242/dev.058479. Development. 2017 10 15; 144(20):3849. PMID: 29042479.
      View in: PubMed
    4. El-Hashash AHK, Turcatel G, Varma S, Berika M, Al Alam D, Warburton D. Retraction: Eya1 protein phosphatase regulates tight junction formation in lung distal epithelium. J. Cell. Sci. doi: 10.1242/102848. J Cell Sci. 2017 10 15; 130(20):3601. PMID: 28972133.
      View in: PubMed
    5. Danopoulos S, Alonso I, Thornton ME, Grubbs BH, Bellusci S, Warburton D, Al Alam D. Human lung branching morphogenesis is orchestrated by the spatiotemporal distribution of ACTA2, SOX2, and SOX9. Am J Physiol Lung Cell Mol Physiol. 2018 01 01; 314(1):L144-L149. PMID: 28971977.
      View in: PubMed
    6. Danopoulos S, Schlieve CR, Grikscheit TC, Al Alam D. Fibroblast Growth Factors in the Gastrointestinal Tract: Twists and Turns. Dev Dyn. 2017 04; 246(4):344-352. PMID: 28198118.
      View in: PubMed
    7. Schall KA, Holoyda KA, Isani M, Lien CL, Al Alam D, Grikscheit TC. Inhibition of Fgf signaling in short bowel syndrome increases weight loss and epithelial proliferation. Surgery. 2017 03; 161(3):694-703. PMID: 27771159.
      View in: PubMed
    8. Danopoulos S, Krainock M, Toubat O, Thornton M, Grubbs B, Al Alam D. Rac1 modulates mammalian lung branching morphogenesis in part through canonical Wnt signaling. Am J Physiol Lung Cell Mol Physiol. 2016 Dec 01; 311(6):L1036-L1049. PMID: 27765763.
      View in: PubMed
    9. Miguel JC, Maxwell AA, Hsieh JJ, Harnisch LC, Al Alam D, Polk DB, Lien CL, Watson AJ, Frey MR. Epidermal growth factor suppresses intestinal epithelial cell shedding through a MAPK-dependent pathway. J Cell Sci. 2017 01 01; 130(1):90-96. PMID: 27026527.
      View in: PubMed
    10. Al Alam D, El Agha E, Sakurai R, Kheirollahi V, Moiseenko A, Danopoulos S, Shrestha A, Schmoldt C, Quantius J, Herold S, Chao CM, Tiozzo C, De Langhe S, Plikus MV, Thornton M, Grubbs B, Minoo P, Rehan VK, Bellusci S. Evidence for the involvement of fibroblast growth factor 10 in lipofibroblast formation during embryonic lung development. Development. 2015 Dec 01; 142(23):4139-50. PMID: 26511927; PMCID: PMC4712831 [Available on 12/01/16].
    11. MacKenzie B, Henneke I, Hezel S, Al Alam D, El Agha E, Chao CM, Quantius J, Wilhelm J, Jones M, Goth K, Li X, Seeger W, Königshoff M, Herold S, Rizvanov AA, Günther A, Bellusci S. Attenuating endogenous Fgfr2b ligands during bleomycin-induced lung fibrosis does not compromise murine lung repair. Am J Physiol Lung Cell Mol Physiol. 2015 May 15; 308(10):L1014-24. PMID: 25820524; PMCID: PMC4437006.
    12. Al Alam D, Danopoulos S, Schall K, Sala FG, Almohazey D, Fernandez GE, Georgia S, Frey MR, Ford HR, Grikscheit T, Bellusci S. Fibroblast growth factor 10 alters the balance between goblet and Paneth cells in the adult mouse small intestine. Am J Physiol Gastrointest Liver Physiol. 2015 Apr 15; 308(8):G678-90. PMID: 25721301; PMCID: PMC4398841.
    13. McElroy SJ, Castle SL, Bernard JK, Almohazey D, Hunter CJ, Bell BA, Al Alam D, Wang L, Ford HR, Frey MR. The ErbB4 ligand neuregulin-4 protects against experimental necrotizing enterocolitis. Am J Pathol. 2014 Oct; 184(10):2768-78. PMID: 25216938; PMCID: PMC4715213.
    14. Zhang P, Chang WH, Fong B, Gao F, Liu C, Al Alam D, Bellusci S, Lu W. Regulation of induced pluripotent stem (iPS) cell induction by Wnt/ß-catenin signaling. J Biol Chem. 2014 Mar 28; 289(13):9221-32. PMID: 24482235; PMCID: PMC3979361.
    15. El Agha E, Herold S, Al Alam D, Quantius J, MacKenzie B, Carraro G, Moiseenko A, Chao CM, Minoo P, Seeger W, Bellusci S. Fgf10-positive cells represent a progenitor cell population during lung development and postnatally. Development. 2014 Jan; 141(2):296-306. PMID: 24353064; PMCID: PMC3879811.
    16. Danopoulos S, Parsa S, Al Alam D, Tabatabai R, Baptista S, Tiozzo C, Carraro G, Wheeler M, Barreto G, Braun T, Li X, Hajihosseini MK, Bellusci S. Transient Inhibition of FGFR2b-ligands signaling leads to irreversible loss of cellular ß-catenin organization and signaling in AER during mouse limb development. PLoS One. 2013; 8(10):e76248. PMID: 24167544; PMCID: PMC3805551.
    17. Al Alam D, Warburton D. Wingless: developmentally important genes that respond adversely to smoking. Thorax. 2013 Aug; 68(8):703-4. PMID: 23611881; PMCID: PMC3726201.
    18. Tiozzo C, Carraro G, Al Alam D, Baptista S, Danopoulos S, Li A, Lavarreda-Pearce M, Li C, De Langhe S, Chan B, Borok Z, Bellusci S, Minoo P. Mesodermal Pten inactivation leads to alveolar capillary dysplasia- like phenotype. J Clin Invest. 2012 Nov; 122(11):3862-72. PMID: 23023706; PMCID: PMC3484434.
    19. Speer AL, Al Alam D, Sala FG, Ford HR, Bellusci S, Grikscheit TC. Fibroblast growth factor 10-fibroblast growth factor receptor 2b mediated signaling is not required for adult glandular stomach homeostasis. PLoS One. 2012; 7(11):e49127. PMID: 23133671; PMCID: PMC3486796.
    20. Al Alam D, Sala FG, Baptista S, Galzote R, Danopoulos S, Tiozzo C, Gage P, Grikscheit T, Warburton D, Frey MR, Bellusci S. FGF9-Pitx2-FGF10 signaling controls cecal formation in mice. Dev Biol. 2012 Sep 15; 369(2):340-8. PMID: 22819677; PMCID: PMC3725282.
    21. El Agha E, Al Alam D, Carraro G, MacKenzie B, Goth K, De Langhe SP, Voswinckel R, Hajihosseini MK, Rehan VK, Bellusci S. Characterization of a novel fibroblast growth factor 10 (Fgf10) knock-in mouse line to target mesenchymal progenitors during embryonic development. PLoS One. 2012; 7(6):e38452. PMID: 22719891; PMCID: PMC3374781.
    22. El-Hashash AH, Turcatel G, Varma S, Berika M, Al Alam D, Warburton D. Eya1 protein phosphatase regulates tight junction formation in lung distal epithelium. J Cell Sci. 2012 Sep 01; 125(Pt 17):4036-48. PMID: 22685326; PMCID: PMC3482315.
    23. Tiozzo C, Danopoulos S, Lavarreda-Pearce M, Baptista S, Varimezova R, Al Alam D, Warburton D, Virender R, De Langhe S, Di Cristofano A, Bellusci S, Minoo P. Embryonic epithelial Pten deletion through Nkx2.1-cre leads to thyroid tumorigenesis in a strain-dependent manner. Endocr Relat Cancer. 2012 Apr; 19(2):111-122. PMID: 22167068; PMCID: PMC4217534.
    24. Al Alam D, Green M, Tabatabai Irani R, Parsa S, Danopoulos S, Sala FG, Branch J, El Agha E, Tiozzo C, Voswinckel R, Jesudason EC, Warburton D, Bellusci S. Contrasting expression of canonical Wnt signaling reporters TOPGAL, BATGAL and Axin2(LacZ) during murine lung development and repair. PLoS One. 2011; 6(8):e23139. PMID: 21858009; PMCID: PMC3153464.
    25. El-Hashash AH, Turcatel G, Al Alam D, Buckley S, Tokumitsu H, Bellusci S, Warburton D. Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium. Development. 2011 Apr; 138(7):1395-407. PMID: 21385765; PMCID: PMC3050666.
    26. El-Hashash AH, Al Alam D, Turcatel G, Rogers O, Li X, Bellusci S, Warburton D. Six1 transcription factor is critical for coordination of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung. Dev Biol. 2011 May 15; 353(2):242-58. PMID: 21385574; PMCID: PMC3114882.
    27. El-Hashash AH, Al Alam D, Turcatel G, Bellusci S, Warburton D. Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung. Dev Biol. 2011 Feb 01; 350(1):112-26. PMID: 21129374; PMCID: PMC3022116.
    28. Parsa S, Kuremoto K, Seidel K, Tabatabai R, Mackenzie B, Yamaza T, Akiyama K, Branch J, Koh CJ, Al Alam D, Klein OD, Bellusci S. Signaling by FGFR2b controls the regenerative capacity of adult mouse incisors. Development. 2010 Nov; 137(22):3743-52. PMID: 20978072; PMCID: PMC3049274.
    29. Fioretti F, Mendoza-Palomares C, Helms M, Al Alam D, Richert L, Arntz Y, Rinckenbach S, Garnier F, Haïkel Y, Gangloff SC, Benkirane-Jessel N. Nanostructured assemblies for dental application. ACS Nano. 2010 Jun 22; 4(6):3277-87. PMID: 20507154.
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    30. Berg T, DeLanghe S, Al Alam D, Utley S, Estrada J, Wang KS. ß-catenin regulates mesenchymal progenitor cell differentiation during hepatogenesis. J Surg Res. 2010 Dec; 164(2):276-85. PMID: 20381814; PMCID: PMC2904820.
    31. Al Alam D, Deslee G, Tournois C, Lamkhioued B, Lebargy F, Merten M, Belaaouaj A, Guenounou M, Gangloff SC. Impaired interleukin-8 chemokine secretion by staphylococcus aureus-activated epithelium and T-cell chemotaxis in cystic fibrosis. Am J Respir Cell Mol Biol. 2010 Jun; 42(6):644-50. PMID: 19597126.
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    32. Tai CC, Curtis JL, Sala FG, Del Moral PM, Chokshi N, Kanard RJ, Al Alam D, Wang J, Burns RC, Ford HR, Grishin A, Wang KS, Bellusci S. Induction of fibroblast growth factor 10 (FGF10) in the ileal crypt epithelium after massive small bowel resection suggests a role for FGF10 in gut adaptation. Dev Dyn. 2009 Feb; 238(2):294-301. PMID: 18773490.
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    33. Deslee G, Dury S, Perotin JM, Al Alam D, Vitry F, Boxio R, Gangloff SC, Guenounou M, Lebargy F, Belaaouaj A. Bronchial epithelial spheroids: an alternative culture model to investigate epithelium inflammation-mediated COPD. Respir Res. 2007 Nov 26; 8:86. PMID: 18039378; PMCID: PMC2214730.
    34. Albers U, Tiaden A, Spirig T, Al Alam D, Goyert SM, Gangloff SC, Hilbi H. Expression of Legionella pneumophila paralogous lipid A biosynthesis genes under different growth conditions. Microbiology. 2007 Nov; 153(Pt 11):3817-29. PMID: 17975091.
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    35. Escotte S, Al Alam D, Le Naour R, Puchelle E, Guenounou M, Gangloff SC. T cell chemotaxis and chemokine release after Staphylococcus aureus interaction with polarized airway epithelium. Am J Respir Cell Mol Biol. 2006 Mar; 34(3):348-54. PMID: 16284362.
      View in: PubMed