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    Denise Al Alam, PhD

    TitleAssistant Professor of Research Surgery
    SchoolKeck School of Medicine of USC
    DepartmentPediatrics
    AddressCHLA 4650 W. Sunset Blvd.
    Off Campus
    Los Angeles California 90026
    Phone+1 323 361 7169
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Danopoulos S, Schlieve CR, Grikscheit TC, Al Alam D. Fibroblast Growth Factors in the Gastrointestinal Tract: Twists and Turns. Dev Dyn. 2017 Apr; 246(4):344-352. PMID: 28198118.
        View in: PubMed
      2. Schall KA, Holoyda KA, Isani M, Lien CL, Al Alam D, Grikscheit TC. Inhibition of Fgf signaling in short bowel syndrome increases weight loss and epithelial proliferation. Surgery. 2017 Mar; 161(3):694-703. PMID: 27771159.
        View in: PubMed
      3. Danopoulos S, Krainock M, Toubat O, Thornton M, Grubbs B, Al Alam D. Rac1 modulates mammalian lung branching morphogenesis in part through canonical Wnt signaling. Am J Physiol Lung Cell Mol Physiol. 2016 Dec 01; 311(6):L1036-L1049. PMID: 27765763.
        View in: PubMed
      4. Miguel JC, Maxwell AA, Hsieh JJ, Harnisch LC, Al Alam D, Polk DB, Lien CL, Watson AJ, Frey MR. Epidermal growth factor suppresses intestinal epithelial cell shedding through a MAPK-dependent pathway. J Cell Sci. 2017 Jan 01; 130(1):90-96. PMID: 27026527.
        View in: PubMed
      5. Al Alam D, El Agha E, Sakurai R, Kheirollahi V, Moiseenko A, Danopoulos S, Shrestha A, Schmoldt C, Quantius J, Herold S, Chao CM, Tiozzo C, De Langhe S, Plikus MV, Thornton M, Grubbs B, Minoo P, Rehan VK, Bellusci S. Evidence for the involvement of fibroblast growth factor 10 in lipofibroblast formation during embryonic lung development. Development. 2015 Dec 01; 142(23):4139-50. PMID: 26511927; PMCID: PMC4712831 [Available on 12/01/16].
      6. Schall KA, Holoyda KA, Grant CN, Levin DE, Torres ER, Maxwell A, Pollack HA, Moats RA, Frey MR, Darehzereshki A, Al Alam D, Lien C, Grikscheit TC. Adult zebrafish intestine resection: a novel model of short bowel syndrome, adaptation, and intestinal stem cell regeneration. Am J Physiol Gastrointest Liver Physiol. 2015 Aug 01; 309(3):G135-45. PMID: 26089336; PMCID: PMC4525108.
      7. MacKenzie B, Henneke I, Hezel S, Al Alam D, El Agha E, Chao CM, Quantius J, Wilhelm J, Jones M, Goth K, Li X, Seeger W, Königshoff M, Herold S, Rizvanov AA, Günther A, Bellusci S. Attenuating endogenous Fgfr2b ligands during bleomycin-induced lung fibrosis does not compromise murine lung repair. Am J Physiol Lung Cell Mol Physiol. 2015 May 15; 308(10):L1014-24. PMID: 25820524; PMCID: PMC4437006.
      8. Al Alam D, Danopoulos S, Schall K, Sala FG, Almohazey D, Fernandez GE, Georgia S, Frey MR, Ford HR, Grikscheit T, Bellusci S. Fibroblast growth factor 10 alters the balance between goblet and Paneth cells in the adult mouse small intestine. Am J Physiol Gastrointest Liver Physiol. 2015 Apr 15; 308(8):G678-90. PMID: 25721301; PMCID: PMC4398841.
      9. McElroy SJ, Castle SL, Bernard JK, Almohazey D, Hunter CJ, Bell BA, Al Alam D, Wang L, Ford HR, Frey MR. The ErbB4 ligand neuregulin-4 protects against experimental necrotizing enterocolitis. Am J Pathol. 2014 Oct; 184(10):2768-78. PMID: 25216938; PMCID: PMC4715213.
      10. Zhang P, Chang WH, Fong B, Gao F, Liu C, Al Alam D, Bellusci S, Lu W. Regulation of induced pluripotent stem (iPS) cell induction by Wnt/ß-catenin signaling. J Biol Chem. 2014 Mar 28; 289(13):9221-32. PMID: 24482235; PMCID: PMC3979361.
      11. El Agha E, Herold S, Al Alam D, Quantius J, MacKenzie B, Carraro G, Moiseenko A, Chao CM, Minoo P, Seeger W, Bellusci S. Fgf10-positive cells represent a progenitor cell population during lung development and postnatally. Development. 2014 Jan; 141(2):296-306. PMID: 24353064; PMCID: PMC3879811.
      12. Danopoulos S, Parsa S, Al Alam D, Tabatabai R, Baptista S, Tiozzo C, Carraro G, Wheeler M, Barreto G, Braun T, Li X, Hajihosseini MK, Bellusci S. Transient Inhibition of FGFR2b-ligands signaling leads to irreversible loss of cellular ß-catenin organization and signaling in AER during mouse limb development. PLoS One. 2013; 8(10):e76248. PMID: 24167544; PMCID: PMC3805551.
      13. Al Alam D, Warburton D. Wingless: developmentally important genes that respond adversely to smoking. Thorax. 2013 Aug; 68(8):703-4. PMID: 23611881; PMCID: PMC3726201.
      14. Tiozzo C, Carraro G, Al Alam D, Baptista S, Danopoulos S, Li A, Lavarreda-Pearce M, Li C, De Langhe S, Chan B, Borok Z, Bellusci S, Minoo P. Mesodermal Pten inactivation leads to alveolar capillary dysplasia- like phenotype. J Clin Invest. 2012 Nov; 122(11):3862-72. PMID: 23023706; PMCID: PMC3484434.
      15. Speer AL, Al Alam D, Sala FG, Ford HR, Bellusci S, Grikscheit TC. Fibroblast growth factor 10-fibroblast growth factor receptor 2b mediated signaling is not required for adult glandular stomach homeostasis. PLoS One. 2012; 7(11):e49127. PMID: 23133671; PMCID: PMC3486796.
      16. Al Alam D, Sala FG, Baptista S, Galzote R, Danopoulos S, Tiozzo C, Gage P, Grikscheit T, Warburton D, Frey MR, Bellusci S. FGF9-Pitx2-FGF10 signaling controls cecal formation in mice. Dev Biol. 2012 Sep 15; 369(2):340-8. PMID: 22819677; PMCID: PMC3725282.
      17. El Agha E, Al Alam D, Carraro G, MacKenzie B, Goth K, De Langhe SP, Voswinckel R, Hajihosseini MK, Rehan VK, Bellusci S. Characterization of a novel fibroblast growth factor 10 (Fgf10) knock-in mouse line to target mesenchymal progenitors during embryonic development. PLoS One. 2012; 7(6):e38452. PMID: 22719891; PMCID: PMC3374781.
      18. El-Hashash AH, Turcatel G, Varma S, Berika M, Al Alam D, Warburton D. Eya1 protein phosphatase regulates tight junction formation in lung distal epithelium. J Cell Sci. 2012 Sep 01; 125(Pt 17):4036-48. PMID: 22685326; PMCID: PMC3482315.
      19. Al Alam D, Green M, Tabatabai Irani R, Parsa S, Danopoulos S, Sala FG, Branch J, El Agha E, Tiozzo C, Voswinckel R, Jesudason EC, Warburton D, Bellusci S. Contrasting expression of canonical Wnt signaling reporters TOPGAL, BATGAL and Axin2(LacZ) during murine lung development and repair. PLoS One. 2011; 6(8):e23139. PMID: 21858009; PMCID: PMC3153464.
      20. El-Hashash AH, Turcatel G, Al Alam D, Buckley S, Tokumitsu H, Bellusci S, Warburton D. Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium. Development. 2011 Apr; 138(7):1395-407. PMID: 21385765; PMCID: PMC3050666.
      21. El-Hashash AH, Al Alam D, Turcatel G, Rogers O, Li X, Bellusci S, Warburton D. Six1 transcription factor is critical for coordination of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung. Dev Biol. 2011 May 15; 353(2):242-58. PMID: 21385574; PMCID: PMC3114882.
      22. El-Hashash AH, Al Alam D, Turcatel G, Bellusci S, Warburton D. Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung. Dev Biol. 2011 Feb 01; 350(1):112-26. PMID: 21129374; PMCID: PMC3022116.
      23. Parsa S, Kuremoto K, Seidel K, Tabatabai R, Mackenzie B, Yamaza T, Akiyama K, Branch J, Koh CJ, Al Alam D, Klein OD, Bellusci S. Signaling by FGFR2b controls the regenerative capacity of adult mouse incisors. Development. 2010 Nov; 137(22):3743-52. PMID: 20978072; PMCID: PMC3049274.
      24. Fioretti F, Mendoza-Palomares C, Helms M, Al Alam D, Richert L, Arntz Y, Rinckenbach S, Garnier F, Haïkel Y, Gangloff SC, Benkirane-Jessel N. Nanostructured assemblies for dental application. ACS Nano. 2010 Jun 22; 4(6):3277-87. PMID: 20507154.
        View in: PubMed
      25. Berg T, DeLanghe S, Al Alam D, Utley S, Estrada J, Wang KS. ß-catenin regulates mesenchymal progenitor cell differentiation during hepatogenesis. J Surg Res. 2010 Dec; 164(2):276-85. PMID: 20381814; PMCID: PMC2904820.
      26. Al Alam D, Deslee G, Tournois C, Lamkhioued B, Lebargy F, Merten M, Belaaouaj A, Guenounou M, Gangloff SC. Impaired interleukin-8 chemokine secretion by staphylococcus aureus-activated epithelium and T-cell chemotaxis in cystic fibrosis. Am J Respir Cell Mol Biol. 2010 Jun; 42(6):644-50. PMID: 19597126.
        View in: PubMed
      27. Tai CC, Curtis JL, Sala FG, Del Moral PM, Chokshi N, Kanard RJ, Al Alam D, Wang J, Burns RC, Ford HR, Grishin A, Wang KS, Bellusci S. Induction of fibroblast growth factor 10 (FGF10) in the ileal crypt epithelium after massive small bowel resection suggests a role for FGF10 in gut adaptation. Dev Dyn. 2009 Feb; 238(2):294-301. PMID: 18773490.
        View in: PubMed
      28. Deslee G, Dury S, Perotin JM, Al Alam D, Vitry F, Boxio R, Gangloff SC, Guenounou M, Lebargy F, Belaaouaj A. Bronchial epithelial spheroids: an alternative culture model to investigate epithelium inflammation-mediated COPD. Respir Res. 2007 Nov 26; 8:86. PMID: 18039378; PMCID: PMC2214730.
      29. Albers U, Tiaden A, Spirig T, Al Alam D, Goyert SM, Gangloff SC, Hilbi H. Expression of Legionella pneumophila paralogous lipid A biosynthesis genes under different growth conditions. Microbiology. 2007 Nov; 153(Pt 11):3817-29. PMID: 17975091.
        View in: PubMed
      30. Escotte S, Al Alam D, Le Naour R, Puchelle E, Guenounou M, Gangloff SC. T cell chemotaxis and chemokine release after Staphylococcus aureus interaction with polarized airway epithelium. Am J Respir Cell Mol Biol. 2006 Mar; 34(3):348-54. PMID: 16284362.
        View in: PubMed