Debbie Mitra, PhD

Title(s)Assistant Professor of Research Ophthalmology
SchoolKeck School of Medicine of USC
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    Collapse Biography 
    Collapse Education and Training
    University of ManitobaBS2000
    McGill UniversityPhD2007
    University of Wisconsin- MadisonPostdoctoral Fellowship- Nanotechnology2008
    University of OttawaPostdoctoral Fellowship- Regenerative Medicine2009

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    Collapse Overview
    Dr. Debbie Mitra obtained her PhD in Chemical Biology from McGill University in Montreal, Canada. She completed a postdoctoral fellowship at the Center for Nanotechnology at the University of Wisconsin-Madison, WI where she conducted research in the fabrication of DNA microarrays and nanotechnology applications in the photolithographic synthesis of oligonucleotides using a Maskless Array Synthesizer for gene assembly. During this time Mitra was the co-inventor of a novel methodology in the fabrication of RNA based microarrays, patented in 2009. She completed a second postdoctoral fellowship at the University of Ottawa, Canada in the field of tissue engineering of artificial corneas fabricated from chemically cross-linked collagen-based materials that mimic the extracellular matrix (ECM) and act as regenerative templates. Mitra is the project manager for the novel stem cell-based therapy for dry AMD-phase 1 clinical trial, funded by the California Institute for Regenerative Medicine. She is also the research-administrative liaison for the USC Roski Eye Institute and the Director of Science and Technology for the USC Institute for Biomedical Therapeutics. Her research interests include regenerative medicine, tissue engineering, DNA nanotechnology and chemistry.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kashani AH, Lebkowski JS, Rahhal FM, Avery RL, Salehi-Had H, Dang W, Lin CM, Mitra D, Zhu D, Thomas BB, Hikita ST, Pennington BO, Johnson LV, Clegg DO, Hinton DR, Humayun MS. A bioengineered retinal pigment epithelial monolayer for advanced, dry age-related macular degeneration. Sci Transl Med. 2018 Apr 04; 10(435). PMID: 29618560.
      View in: PubMed
    2. Koh LB, Islam MM, Mitra D, Noel CW, Merrett K, Odorcic S, Fagerholm P, Jackson WB, Liedberg B, Phopase J, Griffith M. Epoxy cross-linked collagen and collagen-laminin Peptide hydrogels as corneal substitutes. J Funct Biomater. 2013 Aug 28; 4(3):162-77. PMID: 24956085; PMCID: PMC4030907.
    3. Ahn JI, Kuffova L, Merrett K, Mitra D, Forrester JV, Li F, Griffith M. Crosslinked collagen hydrogels as corneal implants: effects of sterically bulky vs. non-bulky carbodiimides as crosslinkers. Acta Biomater. 2013 Aug; 9(8):7796-805. PMID: 23619290.
      View in: PubMed
    4. Merrett K, Liu W, Mitra D, Camm KD, McLaughlin CR, Liu Y, Watsky MA, Li F, Griffith M, Fogg DE. Synthetic neoglycopolymer-recombinant human collagen hybrids as biomimetic crosslinking agents in corneal tissue engineering. Biomaterials. 2009 Oct; 30(29):5403-8. PMID: 19576630.
      View in: PubMed
    5. Lackey JG, Mitra D, Somoza MM, Cerrina F, Damha MJ. Acetal levulinyl ester (ALE) groups for 2'-hydroxyl protection of ribonucleosides in the synthesis of oligoribonucleotides on glass and microarrays. J Am Chem Soc. 2009 Jun 24; 131(24):8496-502. PMID: 19485360.
      View in: PubMed
    6. Mitra D, Damha MJ. A novel approach to the synthesis of DNA and RNA lariats. J Org Chem. 2007 Dec 07; 72(25):9491-500. PMID: 17979285.
      View in: PubMed
    7. Mitra D, Di Cesare N, Sleiman HF. Self-assembly of cyclic metal-DNA nanostructures using ruthenium tris(bipyridine)-branched oligonucleotides. Angew Chem Int Ed Engl. 2004 Nov 05; 43(43):5804-8. PMID: 15523719.
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    8. Vargas-Baca I, Mitra D, Zulyniak HJ, Banerjee J, Sleiman HF. Solid-Phase Synthesis of Transition Metal Linked, Branched Oligonucleotides This work was supported by NSERC (Canada), CFI (Canada) and FCAR (Quebec). The authors gratefully acknowledge Prof. M. J. Damha and his laboratory, McGill University, for helpful discussion. Angew Chem Int Ed Engl. 2001 Dec 17; 40(24):4629-4632. PMID: 12404368.
      View in: PubMed