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    D. Brent Polk, MD

    TitleProfessor of Pediatrics
    SchoolKeck School of Medicine of USC
    DepartmentPediatrics
    AddressCHL Mail Stop 71
    Off Campus
    Los Angeles California 90089
    Phone+1 323 361 2278
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Dubé PE, Yan F, Punit S, Girish N, McElroy SJ, Washington MK, Polk D. Epidermal growth factor receptor inhibits colitis-associated cancer in mice. J Clin Invest. 2012 Aug; 122(8):2780-92. PMID: 22772467; PMCID: PMC3408743.
      2. McElroy SJ, Hobbs S, Kallen M, Tejera N, Rosen MJ, Grishin A, Matta P, Schneider C, Upperman J, Ford H, Polk D, Weitkamp JH. Transactivation of EGFR by LPS induces COX-2 expression in enterocytes. PLoS One. 2012; 7(5):e38373. PMID: 22675459; PMCID: PMC3364993.
      3. Wang L, Liu L, Shi Y, Cao H, Chaturvedi R, Calcutt MW, Hu T, Ren X, Wilson KT, Polk D, Yan F. Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor. PLoS One. 2012; 7(5):e36418. PMID: 22574158; PMCID: PMC3344856.
      4. Weitkamp JH, Koyama T, Rock MT, Correa H, Goettel JA, Matta P, Oswald-Richter K, Rosen MJ, Engelhardt BG, Moore DJ, Polk D. Necrotising enterocolitis is characterised by disrupted immune regulation and diminished mucosal regulatory (FOXP3)/effector (CD4, CD8) T cell ratios. Gut. 2013 Jan; 62(1):73-82. PMID: 22267598; PMCID: PMC3606820.
      5. Yan F, Polk D. Characterization of a probiotic-derived soluble protein which reveals a mechanism of preventive and treatment effects of probiotics on intestinal inflammatory diseases. Gut Microbes. 2012 Jan-Feb; 3(1):25-8. PMID: 22356855; PMCID: PMC3337122.
      6. Yan F, Wang L, Shi Y, Cao H, Liu L, Washington MK, Chaturvedi R, Israel DA, Cao H, Wang B, Peek RM, Wilson KT, Polk D. Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated mice. Am J Physiol Gastrointest Liver Physiol. 2012 Mar 01; 302(5):G504-14. PMID: 22173918; PMCID: PMC3311435.
      7. Zhang Y, Dubé PE, Washington MK, Yan F, Polk D. ErbB2 and ErbB3 regulate recovery from dextran sulfate sodium-induced colitis by promoting mouse colon epithelial cell survival. Lab Invest. 2012 Mar; 92(3):437-50. PMID: 22157714; PMCID: PMC3289719.
      8. Yan F, Polk D. Probiotics and immune health. Curr Opin Gastroenterol. 2011 Oct; 27(6):496-501. PMID: 21897224; PMCID: PMC4006993.
      9. Chaturvedi R, Asim M, Romero-Gallo J, Barry DP, Hoge S, de Sablet T, Delgado AG, Wroblewski LE, Piazuelo MB, Yan F, Israel DA, Casero RA, Correa P, Gobert AP, Polk D, Peek RM, Wilson KT. Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA. Gastroenterology. 2011 Nov; 141(5):1696-708.e1-2. PMID: 21839041; PMCID: PMC3202654.
      10. Ueno PM, Oriá RB, Maier EA, Guedes M, de Azevedo OG, Wu D, Willson T, Hogan SP, Lima AA, Guerrant RL, Polk D, Denson LA, Moore SR. Alanyl-glutamine promotes intestinal epithelial cell homeostasis in vitro and in a murine model of weanling undernutrition. Am J Physiol Gastrointest Liver Physiol. 2011 Oct; 301(4):G612-22. PMID: 21799183; PMCID: PMC3191556.
      11. McElroy SJ, Prince LS, Weitkamp JH, Reese J, Slaughter JC, Polk D. Tumor necrosis factor receptor 1-dependent depletion of mucus in immature small intestine: a potential role in neonatal necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2011 Oct; 301(4):G656-66. PMID: 21737776; PMCID: PMC3191555.
      12. Hilliard VC, Frey MR, Dempsey PJ, Peek RM, Polk D. TNF-a converting enzyme-mediated ErbB4 transactivation by TNF promotes colonic epithelial cell survival. Am J Physiol Gastrointest Liver Physiol. 2011 Aug; 301(2):G338-46. PMID: 21617117; PMCID: PMC3154600.
      13. Yamaoka T, Frey MR, Dise RS, Bernard JK, Polk D. Specific epidermal growth factor receptor autophosphorylation sites promote mouse colon epithelial cell chemotaxis and restitution. Am J Physiol Gastrointest Liver Physiol. 2011 Aug; 301(2):G368-76. PMID: 21617115; PMCID: PMC3154598.
      14. Yan F, Cao H, Cover TL, Washington MK, Shi Y, Liu L, Chaturvedi R, Peek RM, Wilson KT, Polk D. Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism. J Clin Invest. 2011 Jun; 121(6):2242-53. PMID: 21606592; PMCID: PMC3104743.
      15. Hobbs SS, Goettel JA, Liang D, Yan F, Edelblum KL, Frey MR, Mullane MT, Polk D. TNF transactivation of EGFR stimulates cytoprotective COX-2 expression in gastrointestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2011 Aug; 301(2):G220-9. PMID: 21566012; PMCID: PMC3154604.
      16. Rosen MJ, Frey MR, Washington MK, Chaturvedi R, Kuhnhein LA, Matta P, Revetta FL, Wilson KT, Polk D. STAT6 activation in ulcerative colitis: a new target for prevention of IL-13-induced colon epithelial cell dysfunction. Inflamm Bowel Dis. 2011 Nov; 17(11):2224-34. PMID: 21308881; PMCID: PMC3120916.
      17. Frey MR, Carraro G, Batra RK, Polk D, Warburton D. Sprouty keeps bowel kinases regular in colon cancer, while miR-21 targets Sprouty. Cancer Biol Ther. 2011 Jan 01; 11(1):122-4. PMID: 21124074.
        View in: PubMed
      18. Bäuerl C, Pérez-Martínez G, Yan F, Polk D, Monedero V. Functional analysis of the p40 and p75 proteins from Lactobacillus casei BL23. J Mol Microbiol Biotechnol. 2010; 19(4):231-41. PMID: 21178363; PMCID: PMC3019367.
      19. Goettel JA, Liang D, Hilliard VC, Edelblum KL, Broadus MR, Gould KL, Hanks SK, Polk D. KSR1 is a functional protein kinase capable of serine autophosphorylation and direct phosphorylation of MEK1. Exp Cell Res. 2011 Feb 15; 317(4):452-63. PMID: 21144847; PMCID: PMC3038243.
      20. Goettel JA, Scott Algood HM, Olivares-Villagómez D, Washington MK, Chaturvedi R, Wilson KT, Van Kaer L, Polk D. KSR1 protects from interleukin-10 deficiency-induced colitis in mice by suppressing T-lymphocyte interferon-? production. Gastroenterology. 2011 Jan; 140(1):265-74. PMID: 20875416; PMCID: PMC3008308.
      21. Frey MR, Hilliard VC, Mullane MT, Polk D. ErbB4 promotes cyclooxygenase-2 expression and cell survival in colon epithelial cells. Lab Invest. 2010 Oct; 90(10):1415-24. PMID: 20585313; PMCID: PMC2947587.
      22. Yan F, Polk D. Disruption of NF-kappaB signalling by ancient microbial molecules: novel therapies of the future? Gut. 2010 Apr; 59(4):421-6. PMID: 20332512; PMCID: PMC3036986.
      23. Yan F, Polk D. Probiotics: progress toward novel therapies for intestinal diseases. Curr Opin Gastroenterol. 2010 Mar; 26(2):95-101. PMID: 19952741; PMCID: PMC3036989.
      24. Rosen MJ, Moulton DE, Koyama T, Morgan WM, Morrow SE, Herline AJ, Muldoon RL, Wise PE, Polk D, Schwartz DA. Endoscopic ultrasound to guide the combined medical and surgical management of pediatric perianal Crohn's disease. Inflamm Bowel Dis. 2010 Mar; 16(3):461-8. PMID: 19637325; PMCID: PMC2871764.
      25. Weitkamp JH, Rudzinski E, Koyama T, Correa H, Matta P, Alberty B, Polk D. Ontogeny of FOXP3(+) regulatory T cells in the postnatal human small intestinal and large intestinal lamina propria. Pediatr Dev Pathol. 2009 Nov-Dec; 12(6):443-9. PMID: 19203136; PMCID: PMC2844857.
      26. Nagy TA, Frey MR, Yan F, Israel DA, Polk D, Peek RM. Helicobacter pylori regulates cellular migration and apoptosis by activation of phosphatidylinositol 3-kinase signaling. J Infect Dis. 2009 Mar 01; 199(5):641-51. PMID: 19199544; PMCID: PMC2830010.
      27. Yan F, Cao H, Chaturvedi R, Krishna U, Hobbs SS, Dempsey PJ, Peek RM, Cover TL, Washington MK, Wilson KT, Polk D. Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis. Gastroenterology. 2009 Apr; 136(4):1297-1307, e1-3. PMID: 19250983; PMCID: PMC2878739.
      28. Li B, Vincent A, Cates J, Brantley-Sieders DM, Polk D, Young PP. Low levels of tumor necrosis factor alpha increase tumor growth by inducing an endothelial phenotype of monocytes recruited to the tumor site. Cancer Res. 2009 Jan 01; 69(1):338-48. PMID: 19118019; PMCID: PMC2651676.
      29. Vanderpool C, Yan F, Polk D. Mechanisms of probiotic action: Implications for therapeutic applications in inflammatory bowel diseases. Inflamm Bowel Dis. 2008 Nov; 14(11):1585-96. PMID: 18623173.
        View in: PubMed
      30. Frey MR, Edelblum KL, Mullane MT, Liang D, Polk D. The ErbB4 growth factor receptor is required for colon epithelial cell survival in the presence of TNF. Gastroenterology. 2009 Jan; 136(1):217-26. PMID: 18973758; PMCID: PMC2811086.
      31. Edelblum KL, Goettel JA, Koyama T, McElroy SJ, Yan F, Polk D. TNFR1 promotes tumor necrosis factor-mediated mouse colon epithelial cell survival through RAF activation of NF-kappaB. J Biol Chem. 2008 Oct 24; 283(43):29485-94. PMID: 18713739; PMCID: PMC2570867.
      32. Yamaoka T, Yan F, Cao H, Hobbs SS, Dise RS, Tong W, Polk D. Transactivation of EGF receptor and ErbB2 protects intestinal epithelial cells from TNF-induced apoptosis. Proc Natl Acad Sci U S A. 2008 Aug 19; 105(33):11772-7. PMID: 18701712; PMCID: PMC2575333.
      33. McElroy SJ, Frey MR, Yan F, Edelblum KL, Goettel JA, John S, Polk D. Tumor necrosis factor inhibits ligand-stimulated EGF receptor activation through a TNF receptor 1-dependent mechanism. Am J Physiol Gastrointest Liver Physiol. 2008 Aug; 295(2):G285-93. PMID: 18467504; PMCID: PMC2519857.
      34. Edelblum KL, Washington MK, Koyama T, Robine S, Baccarini M, Polk D. Raf protects against colitis by promoting mouse colon epithelial cell survival through NF-kappaB. Gastroenterology. 2008 Aug; 135(2):539-51. PMID: 18598699; PMCID: PMC2640938.
      35. Seth A, Yan F, Polk D, Rao RK. Probiotics ameliorate the hydrogen peroxide-induced epithelial barrier disruption by a PKC- and MAP kinase-dependent mechanism. Am J Physiol Gastrointest Liver Physiol. 2008 Apr; 294(4):G1060-9. PMID: 18292183; PMCID: PMC2653458.
      36. Dise RS, Frey MR, Whitehead RH, Polk D. Epidermal growth factor stimulates Rac activation through Src and phosphatidylinositol 3-kinase to promote colonic epithelial cell migration. Am J Physiol Gastrointest Liver Physiol. 2008 Jan; 294(1):G276-85. PMID: 17991704.
        View in: PubMed
      37. Chen X, Abair TD, Ibanez MR, Su Y, Frey MR, Dise RS, Polk D, Singh AB, Harris RC, Zent R, Pozzi A. Integrin alpha1beta1 controls reactive oxygen species synthesis by negatively regulating epidermal growth factor receptor-mediated Rac activation. Mol Cell Biol. 2007 May; 27(9):3313-26. PMID: 17339338; PMCID: PMC1899972.
      38. Frey MR, Dise RS, Edelblum KL, Polk D. p38 kinase regulates epidermal growth factor receptor downregulation and cellular migration. EMBO J. 2006 Dec 13; 25(24):5683-92. PMID: 17139251; PMCID: PMC1698902.
      39. Yan F, Cao H, Cover TL, Whitehead R, Washington MK, Polk D. Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth. Gastroenterology. 2007 Feb; 132(2):562-75. PMID: 17258729; PMCID: PMC3036990.
      40. Yan F, Polk D. Probiotics as functional food in the treatment of diarrhea. Curr Opin Clin Nutr Metab Care. 2006 Nov; 9(6):717-21. PMID: 17053425.
        View in: PubMed
      41. Ho SB, Dvorak LA, Moor RE, Jacobson AC, Frey MR, Corredor J, Polk D, Shekels LL. Cysteine-rich domains of muc3 intestinal mucin promote cell migration, inhibit apoptosis, and accelerate wound healing. Gastroenterology. 2006 Nov; 131(5):1501-17. PMID: 17101324.
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      42. Batts LE, Polk D, Dubois RN, Kulessa H. Bmp signaling is required for intestinal growth and morphogenesis. Dev Dyn. 2006 Jun; 235(6):1563-70. PMID: 16538672.
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      43. Edelblum KL, Yan F, Yamaoka T, Polk D. Regulation of apoptosis during homeostasis and disease in the intestinal epithelium. Inflamm Bowel Dis. 2006 May; 12(5):413-24. PMID: 16670531.
        View in: PubMed
      44. O'Brien DP, Israel DA, Krishna U, Romero-Gallo J, Nedrud J, Medof ME, Lin F, Redline R, Lublin DM, Nowicki BJ, Franco AT, Ogden S, Williams AD, Polk D, Peek RM. The role of decay-accelerating factor as a receptor for Helicobacter pylori and a mediator of gastric inflammation. J Biol Chem. 2006 May 12; 281(19):13317-23. PMID: 16543227.
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      45. Abbott DW, Polk D. NODing off and Ramping up. Inflamm Bowel Dis. 2005 Sep; 11(9):860-1. PMID: 16116322.
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      46. Yan F, John SK, Wilson G, Jones DS, Washington MK, Polk D. Kinase suppressor of Ras-1 protects intestinal epithelium from cytokine-mediated apoptosis during inflammation. J Clin Invest. 2004 Nov; 114(9):1272-80. PMID: 15520859; PMCID: PMC524224.
      47. Yan F, Polk D. Commensal bacteria in the gut: learning who our friends are. Curr Opin Gastroenterol. 2004 Nov; 20(6):565-71. PMID: 15703684.
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      48. Frey MR, Golovin A, Polk D. Epidermal growth factor-stimulated intestinal epithelial cell migration requires Src family kinase-dependent p38 MAPK signaling. J Biol Chem. 2004 Oct 22; 279(43):44513-21. PMID: 15316018.
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      49. Walker LS, Lipani TA, Greene JW, Caines K, Stutts J, Polk D, Caplan A, Rasquin-Weber A. Recurrent abdominal pain: symptom subtypes based on the Rome II Criteria for pediatric functional gastrointestinal disorders. J Pediatr Gastroenterol Nutr. 2004 Feb; 38(2):187-91. PMID: 14734882.
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      50. Corredor J, Yan F, Shen CC, Tong W, John SK, Wilson G, Whitehead R, Polk D. Tumor necrosis factor regulates intestinal epithelial cell migration by receptor-dependent mechanisms. Am J Physiol Cell Physiol. 2003 Apr; 284(4):C953-61. PMID: 12466150.
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      51. Washington K, Greenson JK, Montgomery E, Shyr Y, Crissinger KD, Polk D, Barnard J, Lauwers GY. Histopathology of ulcerative colitis in initial rectal biopsy in children. Am J Surg Pathol. 2002 Nov; 26(11):1441-9. PMID: 12409720.
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      52. Yan F, Polk D. Probiotic bacterium prevents cytokine-induced apoptosis in intestinal epithelial cells. J Biol Chem. 2002 Dec 27; 277(52):50959-65. PMID: 12393915; PMCID: PMC4006994.
      53. Montgomery R, Ghishan FK, Moyer MS, Polk D, Thompson JF. Research agenda for pediatric gastroenterology, hepatology and nutrition: developmental physiology and pathophysiology. Report of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition for the Children's Digestive Health and Nutrition Foundation. J Pediatr Gastroenterol Nutr. 2002; 35 Suppl 3:S242-5. PMID: 12394358.
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      54. Yan F, John SK, Polk D. Kinase suppressor of Ras determines survival of intestinal epithelial cells exposed to tumor necrosis factor. Cancer Res. 2001 Dec 15; 61(24):8668-75. PMID: 11751383.
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      55. Hernanz-Schulman M, Lowe LH, Johnson J, Neblett WW, Polk D, Perez R, Scheker LE, Stein SM, Heller RM, Cywes R. In vivo visualization of pyloric mucosal hypertrophy in infants with hypertrophic pyloric stenosis: is there an etiologic role? AJR Am J Roentgenol. 2001 Oct; 177(4):843-8. PMID: 11566686.
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      56. Gupta RA, Polk D, Krishna U, Israel DA, Yan F, DuBois RN, Peek RM. Activation of peroxisome proliferator-activated receptor gamma suppresses nuclear factor kappa B-mediated apoptosis induced by Helicobacter pylori in gastric epithelial cells. J Biol Chem. 2001 Aug 17; 276(33):31059-66. PMID: 11397815.
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      57. Yan F, Polk D. Kinase suppressor of ras is necessary for tumor necrosis factor alpha activation of extracellular signal-regulated kinase/mitogen-activated protein kinase in intestinal epithelial cells. Cancer Res. 2001 Feb 01; 61(3):963-9. PMID: 11221891.
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      58. Yan F, Polk D. Aminosalicylic acid inhibits IkappaB kinase alpha phosphorylation of IkappaBalpha in mouse intestinal epithelial cells. J Biol Chem. 1999 Dec 17; 274(51):36631-6. PMID: 10593965.
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      59. Polk D, Tong W. Epidermal and hepatocyte growth factors stimulate chemotaxis in an intestinal epithelial cell line. Am J Physiol. 1999 Dec; 277(6 Pt 1):C1149-59. PMID: 10600766.
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      60. Kaiser GC, Yan F, Polk D. Conversion of TNF alpha from antiproliferative to proliferative ligand in mouse intestinal epithelial cells by regulating mitogen-activated protein kinase. Exp Cell Res. 1999 Jun 15; 249(2):349-58. PMID: 10366434.
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      61. Kaiser GC, Yan F, Polk D. Mesalamine blocks tumor necrosis factor growth inhibition and nuclear factor kappaB activation in mouse colonocytes. Gastroenterology. 1999 Mar; 116(3):602-9. PMID: 10029619; PMCID: PMC3606885.
      62. Hernanz-Schulman M, Neblett WW, Polk D, Johnson JE. Hypertrophied pyloric mucosa in patients with hypertrophic pyloric stenosis. Pediatr Radiol. 1998 Nov; 28(11):901. PMID: 9799331.
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      63. Polk D. Epidermal growth factor receptor-stimulated intestinal epithelial cell migration requires phospholipase C activity. Gastroenterology. 1998 Mar; 114(3):493-502. PMID: 9496939.
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      64. Kaiser GC, Polk D. Tumor necrosis factor alpha regulates proliferation in a mouse intestinal cell line. Gastroenterology. 1997 Apr; 112(4):1231-40. PMID: 9098007.
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      65. Taufiq S, Hernanz-Schulman M, Wheeler AV, Morgan WM, Teague MD, Polk D. Recurrent necrotizing jejunitis in a child. J Pediatr. 1996 Feb; 128(2):246-9. PMID: 8636822.
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      66. Polk D. Shc is a substrate of the rat intestinal epidermal growth factor receptor tyrosine kinase. Gastroenterology. 1995 Dec; 109(6):1845-51. PMID: 7498649.
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      67. Molrine DC, Polk D, Ciamarra A, Phillips N, Ambrosino DM. Impaired human responses to tetanus toxoid in vitamin A-deficient SCID mice reconstituted with human peripheral blood lymphocytes. Infect Immun. 1995 Aug; 63(8):2867-72. PMID: 7622207; PMCID: PMC173389.
      68. Hernanz-Schulman M, Dinauer P, Ambrosino MM, Polk D, Neblett WW. The antral nipple sign of pyloric mucosal prolapse: endoscopic correlation of a new sonographic observation in patients with pyloric stenosis. J Ultrasound Med. 1995 Apr; 14(4):283-7. PMID: 7602686.
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      69. Polk D, McCollum GW, Carpenter G. Cell density-dependent regulation of PLC gamma 1 tyrosine phosphorylation and catalytic activity in an intestinal cell line (IEC-6). J Cell Physiol. 1995 Mar; 162(3):427-33. PMID: 7532179.
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      70. Polk D. Ontogenic regulation of phospholipase C-gamma 1 activity and expression in the rat small intestine. Gastroenterology. 1994 Jul; 107(1):109-16. PMID: 8020653.
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      71. Sacks AI, Acra SA, Dykes W, Polk D, Barnard JA, Pietsch J, Ghishan FK. Intestinal Na+/H+ exchanger activity is up-regulated by bowel resection in the weanling rat. Pediatr Res. 1993 Mar; 33(3):215-20. PMID: 8384709.
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      72. Polk D, Hattner JA, Kerner JA. Improved growth and disease activity after intermittent administration of a defined formula diet in children with Crohn's disease. JPEN J Parenter Enteral Nutr. 1992 Nov-Dec; 16(6):499-504. PMID: 1494204.
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      73. Polk D, Steele RW. Bacterial meningitis presenting with normal cerebrospinal fluid. Pediatr Infect Dis J. 1987 Nov; 6(11):1040-2. PMID: 3320931.
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