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David R. Hinton, MD

TitleProfessor of Pathology
InstitutionUniversity of Southern California
DepartmentPathology
AddressNRT 1450 Biggy Street
Off Campus
Los Angeles CA 90089-9092
Phone+1 310 415 6093
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    Other Positions
    TitleGavin S. Herbert Professorship in Vision Research

    TitleAssociate Dean For Vision Science

    TitleVice Chair of Pathology

    TitleDirector, Dean's Research Scholars Program

    TitleExam Committee Facilitator


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    Collapse Overview
    Dr Hinton investigates the pathogenesis of blinding retinal diseases including age related macular degeneration (AMD) and proliferative vitreoretinopathy(PVR). In particular, he is interested in how alterations in the retinal microenvironment can promote the development of intraocular fibrosis, proliferative membranes and neovascular choroidal responses. His work has established the central role of the retinal pigment epithelial (RPE) cell in these disorders, and has demonstrated novel mechanisms for growth factor activation of the RPE with resulting alterations in migration, proliferation and gene expression. He has developed and validated several in vitro and in vivo models of PVR and choroidal neovascularization and has used these models to elucidate basic mechanisms of disease and to evaluate novel therapeutic approaches to the disorders. He is especially interested in therapeutic approaches involving manipulation of growth factor receptors and their intracellular signaling pathways. He has now extended this work into investigating genetic polymorphisms that result in susceptibility to these disorders in human populations. Most recently, Dr Hinton’s lab has been evaluating endogenous neuroprotectants (eg pigment epithelial derived factor) and chaperones (alpha B crystallin) for their therapeutic potential. He has also developed methods for differentiating RPE cells from human embryonic stem cells and is evaluating these cells for their potential for cellular therapy for patients with AMD. In a collaborative Program Project with investigators at the Cleveland Clinic, Dr Hinton investigates the immunopathogenesis of demyelinating diseases of the brain and spinal cord in animal models.


    Collapse Research 
    Collapse Research Activities and Funding
    An Experimental Approach to Maculopathy
    NIH/NEI R01EY001545Feb 1, 1983 - Mar 31, 2017
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kashani AH, Lebkowski JS, Rahhal FM, Avery RL, Salehi-Had H, Dang W, Lin CM, Mitra D, Zhu D, Thomas BB, Hikita ST, Pennington BO, Johnson LV, Clegg DO, Hinton D, Humayun MS. A bioengineered retinal pigment epithelial monolayer for advanced, dry age-related macular degeneration. Sci Transl Med. 2018 Apr 04; 10(435). PMID: 29618560.
      View in: PubMed
    2. Kerur N, Fukuda S, Banerjee D, Kim Y, Fu D, Apicella I, Varshney A, Yasuma R, Fowler BJ, Baghdasaryan E, Marion KM, Huang X, Yasuma T, Hirano Y, Serbulea V, Ambati M, Ambati VL, Kajiwara Y, Ambati K, Hirahara S, Bastos-Carvalho A, Ogura Y, Terasaki H, Oshika T, Kim KB, Hinton D, Leitinger N, Cambier JC, Buxbaum JD, Kenney MC, Jazwinski SM, Nagai H, Hara I, West AP, Fitzgerald KA, Sadda SR, Gelfand BD, Ambati J. cGAS drives noncanonical-inflammasome activation in age-related macular degeneration. Nat Med. 2018 Jan; 24(1):50-61. PMID: 29176737.
      View in: PubMed
    3. Jiao C, Eliott D, Spee C, He S, Wang K, Mullins RF, Hinton D, Sohn EH. APOPTOSIS AND ANGIOFIBROSIS IN DIABETIC TRACTIONAL MEMBRANES AFTER VASCULAR ENDOTHELIAL GROWTH FACTOR INHIBITION: Results of a Prospective Trial. Report No. 2. Retina. 2017 Nov 22. PMID: 29190236.
      View in: PubMed
    4. Fernandes RAB, Stefanini FR, Falabella P, Koss MJ, Wells T, Diniz B, Ribeiro R, Schor P, Maia M, Penha FM, Hinton D, Tai YC, Humayun M. Development of a new tissue injector for subretinal transplantation of human embryonic stem cell derived retinal pigmented epithelium. Int J Retina Vitreous. 2017; 3:41. PMID: 29093829.
      View in: PubMed
    5. Lin TC, Seiler MJ, Zhu D, Falabella P, Hinton D, Clegg DO, Humayun MS, Thomas BB. Assessment of Safety and Functional Efficacy of Stem Cell-Based Therapeutic Approaches Using Retinal Degenerative Animal Models. Stem Cells Int. 2017; 2017:9428176. PMID: 28928775.
      View in: PubMed
    6. Minasyan L, Sreekumar PG, Hinton D, Kannan R. Protective Mechanisms of the Mitochondrial-Derived Peptide Humanin in Oxidative and Endoplasmic Reticulum Stress in RPE Cells. Oxid Med Cell Longev. 2017; 2017:1675230. PMID: 28814984.
      View in: PubMed
    7. Sreekumar PG, Hinton D, Kannan R. Endoplasmic reticulum-mitochondrial crosstalk: a novel role for the mitochondrial peptide humanin. Neural Regen Res. 2017 Jan; 12(1):35-38. PMID: 28250736.
      View in: PubMed
    8. Huang AS, Saraswathy S, Dastiridou A, Begian A, Legaspi H, Mohindroo C, Tan JC, Francis BA, Caprioli J, Hinton D, Weinreb RN. Aqueous Angiography with Fluorescein and Indocyanine Green in Bovine Eyes. Transl Vis Sci Technol. 2016 Nov; 5(6):5. PMID: 27847692.
      View in: PubMed
    9. Matsunaga D, Sreekumar PG, Ishikawa K, Terasaki H, Barron E, Cohen P, Kannan R, Hinton D. Humanin Protects RPE Cells from Endoplasmic Reticulum Stress-Induced Apoptosis by Upregulation of Mitochondrial Glutathione. PLoS One. 2016; 11(10):e0165150. PMID: 27783653.
      View in: PubMed
    10. Savarin C, Bergmann CC, Hinton D, Stohlman SA. Differential Regulation of Self-reactive CD4+ T Cells in Cervical Lymph Nodes and Central Nervous System during Viral Encephalomyelitis. Front Immunol. 2016; 7:370. PMID: 27708643.
      View in: PubMed
    11. Huang AS, Saraswathy S, Dastiridou A, Begian A, Mohindroo C, Tan JC, Francis BA, Hinton D, Weinreb RN. Aqueous Angiography-Mediated Guidance of Trabecular Bypass Improves Angiographic Outflow in Human Enucleated Eyes. Invest Ophthalmol Vis Sci. 2016 09 01; 57(11):4558-65. PMID: 27588614; PMCID: PMC5017267.
    12. Koss MJ, Falabella P, Stefanini FR, Pfister M, Thomas BB, Kashani AH, Brant R, Zhu D, Clegg DO, Hinton D, Humayun MS. Subretinal implantation of a monolayer of human embryonic stem cell-derived retinal pigment epithelium: a feasibility and safety study in Yucatán minipigs. Graefes Arch Clin Exp Ophthalmol. 2016 Aug; 254(8):1553-65. PMID: 27335025.
      View in: PubMed
    13. Thomas BB, Zhu D, Zhang L, Thomas PB, Hu Y, Nazari H, Stefanini F, Falabella P, Clegg DO, Hinton D, Humayun MS. Survival and Functionality of hESC-Derived Retinal Pigment Epithelium Cells Cultured as a Monolayer on Polymer Substrates Transplanted in RCS Rats. Invest Ophthalmol Vis Sci. 2016 05 01; 57(6):2877-87. PMID: 27233037.
      View in: PubMed
    14. Brant Fernandes RA, Koss MJ, Falabella P, Stefanini FR, Maia M, Diniz B, Ribeiro R, Hu Y, Hinton D, Clegg DO, Chader G, Humayun MS. An Innovative Surgical Technique for Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Pigmented Epithelium in Yucatan Mini Pigs: Preliminary Results. Ophthalmic Surg Lasers Imaging Retina. 2016 Apr 01; 47(4):342-51. PMID: 27065374.
      View in: PubMed
    15. Kochounian H, Zhang Z, Spee C, Hinton D, Fong HK. Targeting of exon VI-skipping human RGR-opsin to the plasma membrane of pigment epithelium and co-localization with terminal complement complex C5b-9. Mol Vis. 2016; 22:213-23. PMID: 27011730; PMCID: PMC4783578.
    16. Sreekumar PG, Ishikawa K, Spee C, Mehta HH, Wan J, Yen K, Cohen P, Kannan R, Hinton D. The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction. Invest Ophthalmol Vis Sci. 2016 Mar; 57(3):1238-53. PMID: 26990160; PMCID: PMC4811181.
    17. Valentin-Torres A, Savarin C, Hinton D, Phares TW, Bergmann CC, Stohlman SA. Sustained TNF production by central nervous system infiltrating macrophages promotes progressive autoimmune encephalomyelitis. J Neuroinflammation. 2016 Feb 22; 13:46. PMID: 26906225; PMCID: PMC4763407.
    18. Ishikawa K, Sreekumar PG, Spee C, Nazari H, Zhu D, Kannan R, Hinton D. aB-Crystallin Regulates Subretinal Fibrosis by Modulation of Epithelial-Mesenchymal Transition. Am J Pathol. 2016 Apr; 186(4):859-73. PMID: 26878210; PMCID: PMC4822331 [Available on 04/01/17].
    19. Saraswathy S, Tan JC, Yu F, Francis BA, Hinton D, Weinreb RN, Huang AS. Aqueous Angiography: Real-Time and Physiologic Aqueous Humor Outflow Imaging. PLoS One. 2016; 11(1):e0147176. PMID: 26807586; PMCID: PMC4725949.
    20. Ishikawa K, He S, Terasaki H, Nazari H, Zhang H, Spee C, Kannan R, Hinton D. Resveratrol inhibits epithelial-mesenchymal transition of retinal pigment epithelium and development of proliferative vitreoretinopathy. Sci Rep. 2015 Nov 10; 5:16386. PMID: 26552368; PMCID: PMC4639835.
    21. He S, Barron E, Ishikawa K, Nazari Khanamiri H, Spee C, Zhou P, Kase S, Wang Z, Dustin LD, Hinton D. Inhibition of DNA Methylation and Methyl-CpG-Binding Protein 2 Suppresses RPE Transdifferentiation: Relevance to Proliferative Vitreoretinopathy. Invest Ophthalmol Vis Sci. 2015 Aug; 56(9):5579-89. PMID: 26305530; PMCID: PMC4553933.
    22. Zhang H, He S, Spee C, Ishikawa K, Hinton D. SIRT1 mediated inhibition of VEGF/VEGFR2 signaling by Resveratrol and its relevance to choroidal neovascularization. Cytokine. 2015 Dec; 76(2):549-552. PMID: 26174951; PMCID: PMC4605850 [Available on 12/01/16].
    23. Butchi N, Kapil P, Puntambekar S, Stohlman SA, Hinton D, Bergmann CC. Myd88 Initiates Early Innate Immune Responses and Promotes CD4 T Cells during Coronavirus Encephalomyelitis. J Virol. 2015 Sep; 89(18):9299-312. PMID: 26136579; PMCID: PMC4542380.
    24. Puntambekar SS, Hinton D, Yin X, Savarin C, Bergmann CC, Trapp BD, Stohlman SA. Interleukin-10 is a critical regulator of white matter lesion containment following viral induced demyelination. Glia. 2015 Jun 30. PMID: 26132901.
      View in: PubMed
    25. Nazari H, Zhang L, Zhu D, Chader GJ, Falabella P, Stefanini F, Rowland T, Clegg DO, Kashani AH, Hinton D, Humayun MS. Stem cell based therapies for age-related macular degeneration: The promises and the challenges. Prog Retin Eye Res. 2015 Sep; 48:1-39. PMID: 26113213.
      View in: PubMed
    26. Kannan R, Sreekumar PG, Hinton D. Alpha crystallins in the retinal pigment epithelium and implications for the pathogenesis and treatment of age-related macular degeneration. Biochim Biophys Acta. 2016 Jan; 1860(1 Pt B):258-68. PMID: 26026469; PMCID: PMC4662643 [Available on 01/01/17].
    27. Savarin C, Hinton D, Valentin-Torres A, Chen Z, Trapp BD, Bergmann CC, Stohlman SA. Astrocyte response to IFN-? limits IL-6-mediated microglia activation and progressive autoimmune encephalomyelitis. J Neuroinflammation. 2015 Apr 22; 12:79. PMID: 25896970; PMCID: PMC4410573.
    28. Chan N, He S, Spee CK, Ishikawa K, Hinton D. Attenuation of choroidal neovascularization by histone deacetylase inhibitor. PLoS One. 2015; 10(3):e0120587. PMID: 25807249; PMCID: PMC4373846.
    29. Ishikawa K, Kannan R, Hinton D. Molecular mechanisms of subretinal fibrosis in age-related macular degeneration. Exp Eye Res. 2016 Jan; 142:19-25. PMID: 25773985.
      View in: PubMed
    30. Hwang M, Phares TW, Hinton D, Stohlman SA, Bergmann CC, Min B. Distinct CD4 T-cell effects on primary versus recall CD8 T-cell responses during viral encephalomyelitis. Immunology. 2015 Mar; 144(3):374-386. PMID: 25187405.
      View in: PubMed
    31. Hirsch L, Nazari H, Sreekumar PG, Kannan R, Dustin L, Zhu D, Barron E, Hinton D. TGF-ß2 secretion from RPE decreases with polarization and becomes apically oriented. Cytokine. 2015 Feb; 71(2):394-6. PMID: 25496702; PMCID: PMC4297550.
    32. Hirano Y, Yasuma T, Mizutani T, Fowler BJ, Tarallo V, Yasuma R, Kim Y, Bastos-Carvalho A, Kerur N, Gelfand BD, Bogdanovich S, He S, Zhang X, Nozaki M, Ijima R, Kaneko H, Ogura Y, Terasaki H, Nagai H, Haro I, Núñez G, Ambati BK, Hinton D, Ambati J. IL-18 is not therapeutic for neovascular age-related macular degeneration. Nat Med. 2014 Dec; 20(12):1372-5. PMID: 25473914; PMCID: PMC4275546.
    33. Kannan R, Hinton D. Sodium iodate induced retinal degeneration: new insights from an old model. Neural Regen Res. 2014 Dec 01; 9(23):2044-5. PMID: 25657718; PMCID: PMC4316465.
    34. Fowler BJ, Gelfand BD, Kim Y, Kerur N, Tarallo V, Hirano Y, Amarnath S, Fowler DH, Radwan M, Young MT, Pittman K, Kubes P, Agarwal HK, Parang K, Hinton D, Bastos-Carvalho A, Li S, Yasuma T, Mizutani T, Yasuma R, Wright C, Ambati J. Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity. Science. 2014 Nov 21; 346(6212):1000-3. PMID: 25414314; PMCID: PMC4274127.
    35. Hsiung J, Zhu D, Hinton D. Polarized human embryonic stem cell-derived retinal pigment epithelial cell monolayers have higher resistance to oxidative stress-induced cell death than nonpolarized cultures. Stem Cells Transl Med. 2015 Jan; 4(1):10-20. PMID: 25411476; PMCID: PMC4275015.
    36. Sur A, Kesaraju S, Prentice H, Ayyanathan K, Baronas-Lowell D, Zhu D, Hinton D, Blanks J, Weissbach H. Pharmacological protection of retinal pigmented epithelial cells by sulindac involves PPAR-a. Proc Natl Acad Sci U S A. 2014 Nov 25; 111(47):16754-9. PMID: 25385631; PMCID: PMC4250171.
    37. Kim Y, Tarallo V, Kerur N, Yasuma T, Gelfand BD, Bastos-Carvalho A, Hirano Y, Yasuma R, Mizutani T, Fowler BJ, Li S, Kaneko H, Bogdanovich S, Ambati BK, Hinton D, Hauswirth WW, Hakem R, Wright C, Ambati J. DICER1/Alu RNA dysmetabolism induces Caspase-8-mediated cell death in age-related macular degeneration. Proc Natl Acad Sci U S A. 2014 Nov 11; 111(45):16082-7. PMID: 25349431; PMCID: PMC4234570.
    38. de Aquino MT, Kapil P, Hinton D, Phares TW, Puntambekar SS, Savarin C, Bergmann CC, Stohlman SA. IL-27 limits central nervous system viral clearance by promoting IL-10 and enhances demyelination. J Immunol. 2014 Jul 01; 193(1):285-94. PMID: 24890725; PMCID: PMC4067872.
    39. Zhou P, Kannan R, Spee C, Sreekumar PG, Dou G, Hinton D. Protection of retina by aB crystallin in sodium iodate induced retinal degeneration. PLoS One. 2014; 9(5):e98275. PMID: 24874187; PMCID: PMC4038555.
    40. Wang W, Sreekumar PG, Valluripalli V, Shi P, Wang J, Lin YA, Cui H, Kannan R, Hinton D, MacKay JA. Protein polymer nanoparticles engineered as chaperones protect against apoptosis in human retinal pigment epithelial cells. J Control Release. 2014 Oct 10; 191:4-14. PMID: 24780268.
      View in: PubMed
    41. Sonoda S, Nagineni CN, Kitamura M, Spee C, Kannan R, Hinton D. Ceramide inhibits connective tissue growth factor expression by human retinal pigment epithelial cells. Cytokine. 2014 Aug; 68(2):137-40. PMID: 24758915; PMCID: PMC4051296.
    42. Kapil P, Stohlman SA, Hinton D, Bergmann CC. PKR mediated regulation of inflammation and IL-10 during viral encephalomyelitis. J Neuroimmunol. 2014 May 15; 270(1-2):1-12. PMID: 24642385; PMCID: PMC4019976.
    43. Savarin C, Bergmann CC, Hinton D, Stohlman SA. MMP-independent role of TIMP-1 at the blood brain barrier during viral encephalomyelitis. ASN Neuro. 2013 Nov 26; 5(5):e00127. PMID: 24156369; PMCID: PMC3840398.
    44. Kerur N, Hirano Y, Tarallo V, Fowler BJ, Bastos-Carvalho A, Yasuma T, Yasuma R, Kim Y, Hinton D, Kirschning CJ, Gelfand BD, Ambati J. TLR-independent and P2X7-dependent signaling mediate Alu RNA-induced NLRP3 inflammasome activation in geographic atrophy. Invest Ophthalmol Vis Sci. 2013 Nov 11; 54(12):7395-401. PMID: 24114535; PMCID: PMC3825570.
    45. Butchi NB, Hinton D, Stohlman SA, Kapil P, Fensterl V, Sen GC, Bergmann CC. Ifit2 deficiency results in uncontrolled neurotropic coronavirus replication and enhanced encephalitis via impaired alpha/beta interferon induction in macrophages. J Virol. 2014 Jan; 88(2):1051-64. PMID: 24198415; PMCID: PMC3911674.
    46. de Aquino MT, Puntambekar SS, Savarin C, Bergmann CC, Phares TW, Hinton D, Stohlman SA. Role of CD25(+) CD4(+) T cells in acute and persistent coronavirus infection of the central nervous system. Virology. 2013 Dec; 447(1-2):112-20. PMID: 24210105; PMCID: PMC3906923.
    47. Phares TW, DiSano KD, Hinton D, Hwang M, Zajac AJ, Stohlman SA, Bergmann CC. IL-21 optimizes T cell and humoral responses in the central nervous system during viral encephalitis. J Neuroimmunol. 2013 Oct 15; 263(1-2):43-54. PMID: 23992866; PMCID: PMC3796038.
    48. Diniz B, Thomas P, Thomas B, Ribeiro R, Hu Y, Brant R, Ahuja A, Zhu D, Liu L, Koss M, Maia M, Chader G, Hinton D, Humayun MS. Subretinal implantation of retinal pigment epithelial cells derived from human embryonic stem cells: improved survival when implanted as a monolayer. Invest Ophthalmol Vis Sci. 2013 Jul 26; 54(7):5087-96. PMID: 23833067; PMCID: PMC3726243.
    49. Ribeiro RM, Oregon A, Diniz B, Fernandes RB, Koss MJ, Charafeddin W, Hu Y, Thomas P, Thomas BB, Maia M, Chader GJ, Hinton D, Humayun MS. In vivo detection of hESC-RPE cells via confocal near-infrared fundus reflectance. Ophthalmic Surg Lasers Imaging Retina. 2013 Jul-Aug; 44(4):380-4. PMID: 23883533.
      View in: PubMed
    50. Sreekumar PG, Chothe P, Sharma KK, Baid R, Kompella U, Spee C, Kannan N, Manh C, Ryan SJ, Ganapathy V, Kannan R, Hinton D. Antiapoptotic properties of a-crystallin-derived peptide chaperones and characterization of their uptake transporters in human RPE cells. Invest Ophthalmol Vis Sci. 2013 Apr 17; 54(4):2787-98. PMID: 23532520; PMCID: PMC3632268.
    51. He S, Li X, Chan N, Hinton D. Review: Epigenetic mechanisms in ocular disease. Mol Vis. 2013; 19:665-74. PMID: 23559860; PMCID: PMC3611946.
    52. Phares TW, Stohlman SA, Hinton D, Bergmann CC. Astrocyte-derived CXCL10 drives accumulation of antibody-secreting cells in the central nervous system during viral encephalomyelitis. J Virol. 2013 Mar; 87(6):3382-92. PMID: 23302888; PMCID: PMC3592145.
    53. Phares TW, Stohlman SA, Hinton D, Bergmann CC. Enhanced CD8 T-cell anti-viral function and clinical disease in B7-H1-deficient mice requires CD4 T cells during encephalomyelitis. J Neuroinflammation. 2012 Dec 14; 9:269. PMID: 23237504; PMCID: PMC3545890.
    54. Zhu G, Ye R, Jung DY, Barron E, Friedline RH, Benoit VM, Hinton D, Kim JK, Lee AS. GRP78 plays an essential role in adipogenesis and postnatal growth in mice. FASEB J. 2013 Mar; 27(3):955-64. PMID: 23180827; PMCID: PMC3574283.
    55. Sohn EH, He S, Kim LA, Salehi-Had H, Javaheri M, Spee C, Dustin L, Hinton D, Eliott D. Angiofibrotic response to vascular endothelial growth factor inhibition in diabetic retinal detachment: report no. 1. Arch Ophthalmol. 2012 Sep; 130(9):1127-34. PMID: 22965588; PMCID: PMC3984910.
    56. Gundimeda U, McNeill TH, Elhiani AA, Schiffman JE, Hinton D, Gopalakrishna R. Green tea polyphenols precondition against cell death induced by oxygen-glucose deprivation via stimulation of laminin receptor, generation of reactive oxygen species, and activation of protein kinase Ce. J Biol Chem. 2012 Oct 05; 287(41):34694-708. PMID: 22879598; PMCID: PMC3464573.
    57. Dridi S, Hirano Y, Tarallo V, Kim Y, Fowler BJ, Ambati BK, Bogdanovich S, Chiodo VA, Hauswirth WW, Kugel JF, Goodrich JA, Ponicsan SL, Hinton D, Kleinman ME, Baffi JZ, Gelfand BD, Ambati J. ERK1/2 activation is a therapeutic target in age-related macular degeneration. Proc Natl Acad Sci U S A. 2012 Aug 21; 109(34):13781-6. PMID: 22869729.
      View in: PubMed
    58. Hu Y, Liu L, Lu B, Zhu D, Ribeiro R, Diniz B, Thomas PB, Ahuja AK, Hinton D, Tai YC, Hikita ST, Johnson LV, Clegg DO, Thomas BB, Humayun MS. A novel approach for subretinal implantation of ultrathin substrates containing stem cell-derived retinal pigment epithelium monolayer. Ophthalmic Res. 2012; 48(4):186-91. PMID: 22868580.
      View in: PubMed
    59. Lu B, Zhu D, Hinton D, Humayun MS, Tai YC. Mesh-supported submicron parylene-C membranes for culturing retinal pigment epithelial cells. Biomed Microdevices. 2012 Aug; 14(4):659-67. PMID: 22391881.
      View in: PubMed
    60. Hindinger C, Bergmann CC, Hinton D, Phares TW, Parra GI, Hussain S, Savarin C, Atkinson RD, Stohlman SA. IFN-? signaling to astrocytes protects from autoimmune mediated neurological disability. PLoS One. 2012; 7(7):e42088. PMID: 22848713; PMCID: PMC3407093.
    61. Dou G, Sreekumar PG, Spee C, He S, Ryan SJ, Kannan R, Hinton D. Deficiency of aB crystallin augments ER stress-induced apoptosis by enhancing mitochondrial dysfunction. Free Radic Biol Med. 2012 Sep 01; 53(5):1111-22. PMID: 22781655; PMCID: PMC3454510.
    62. Kannan R, Sreekumar PG, Hinton D. Novel roles for a-crystallins in retinal function and disease. Prog Retin Eye Res. 2012 Nov; 31(6):576-604. PMID: 22721717; PMCID: PMC3472046.
    63. Savarin C, Stohlman SA, Hinton D, Ransohoff RM, Cua DJ, Bergmann CC. IFN-? protects from lethal IL-17 mediated viral encephalomyelitis independent of neutrophils. J Neuroinflammation. 2012 May 29; 9:104. PMID: 22642802; PMCID: PMC3419086.
    64. Tarallo V, Hirano Y, Gelfand BD, Dridi S, Kerur N, Kim Y, Cho WG, Kaneko H, Fowler BJ, Bogdanovich S, Albuquerque RJ, Hauswirth WW, Chiodo VA, Kugel JF, Goodrich JA, Ponicsan SL, Chaudhuri G, Murphy MP, Dunaief JL, Ambati BK, Ogura Y, Yoo JW, Lee DK, Provost P, Hinton D, Núñez G, Baffi JZ, Kleinman ME, Ambati J. DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88. Cell. 2012 May 11; 149(4):847-59. PMID: 22541070.
      View in: PubMed
    65. Sreekumar PG, Spee C, Ryan SJ, Cole SP, Kannan R, Hinton D. Mechanism of RPE cell death in a-crystallin deficient mice: a novel and critical role for MRP1-mediated GSH efflux. PLoS One. 2012; 7(3):e33420. PMID: 22442691; PMCID: PMC3307734.
    66. Xu J, Zhu D, Sonoda S, He S, Spee C, Ryan SJ, Hinton D. Over-expression of BMP4 inhibits experimental choroidal neovascularization by modulating VEGF and MMP-9. Angiogenesis. 2012 Jun; 15(2):213-27. PMID: 22392094; PMCID: PMC3413482.
    67. Phares TW, Stohlman SA, Hwang M, Min B, Hinton D, Bergmann CC. CD4 T cells promote CD8 T cell immunity at the priming and effector site during viral encephalitis. J Virol. 2012 Mar; 86(5):2416-27. PMID: 22205741; PMCID: PMC3302259.
    68. Amin EM, Oltean S, Hua J, Gammons MV, Hamdollah-Zadeh M, Welsh GI, Cheung MK, Ni L, Kase S, Rennel ES, Symonds KE, Nowak DG, Royer-Pokora B, Saleem MA, Hagiwara M, Schumacher VA, Harper SJ, Hinton D, Bates DO, Ladomery MR. WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicing. Cancer Cell. 2011 Dec 13; 20(6):768-80. PMID: 22172722.
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    69. Kannan R, Sreekumar PG, Hinton D. VEGF and PEDF secretion in ARPE-19 and fhRPE cells. Invest Ophthalmol Vis Sci. 2011 Nov 21; 52(12):9047. PMID: 22104197; PMCID: PMC3231800.
    70. Sreekumar PG, Hinton D, Kannan R. Methionine sulfoxide reductase A: Structure, function and role in ocular pathology. World J Biol Chem. 2011 Aug 26; 2(8):184-92. PMID: 21909460; PMCID: PMC3163237.
    71. Khankan R, Oliver N, He S, Ryan SJ, Hinton D. Regulation of fibronectin-EDA through CTGF domain-specific interactions with TGFß2 and its receptor TGFßRII. Invest Ophthalmol Vis Sci. 2011 Jul 07; 52(8):5068-78. PMID: 21571675; PMCID: PMC3176038.
    72. Lee NG, Berry JL, Lee TC, Wang AT, Honowitz S, Murphree AL, Varshney N, Hinton D, Fawzi AA. Sonoporation enhances chemotherapeutic efficacy in retinoblastoma cells in vitro. Invest Ophthalmol Vis Sci. 2011 Jun 01; 52(6):3868-73. PMID: 21273549; PMCID: PMC3109062.
    73. Puntambekar SS, Bergmann CC, Savarin C, Karp CL, Phares TW, Parra GI, Hinton D, Stohlman SA. Shifting hierarchies of interleukin-10-producing T cell populations in the central nervous system during acute and persistent viral encephalomyelitis. J Virol. 2011 Jul; 85(13):6702-13. PMID: 21525347; PMCID: PMC3126516.
    74. Marques CP, Kapil P, Hinton D, Hindinger C, Nutt SL, Ransohoff RM, Phares TW, Stohlman SA, Bergmann CC. CXCR3-dependent plasma blast migration to the central nervous system during viral encephalomyelitis. J Virol. 2011 Jul; 85(13):6136-47. PMID: 21507985; PMCID: PMC3126522.
    75. Sadler TR, Nguyen PT, Yang J, Givrad TK, Mayer EA, Maarek JM, Hinton D, Holschneider DP. Antenatal maternal stress alters functional brain responses in adult offspring during conditioned fear. Brain Res. 2011 Apr 18; 1385:163-74. PMID: 21300034; PMCID: PMC3065538.
    76. Couldwell WT, Surnock AA, Tobia AJ, Cabana BE, Stillerman CB, Forsyth PA, Appley AJ, Spence AM, Hinton D, Chen TC. A phase 1/2 study of orally administered synthetic hypericin for treatment of recurrent malignant gliomas. Cancer. 2011 Nov 01; 117(21):4905-15. PMID: 21456013.
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    78. Zhu D, Deng X, Spee C, Sonoda S, Hsieh CL, Barron E, Pera M, Hinton D. Polarized secretion of PEDF from human embryonic stem cell-derived RPE promotes retinal progenitor cell survival. Invest Ophthalmol Vis Sci. 2011 Mar 01; 52(3):1573-85. PMID: 21087957; PMCID: PMC4183377.
    79. Abdallah W, Ameri H, Barron E, Chader GJ, Greenbaum E, Hinton D, Humayun MS. Vitreal oxygenation in retinal ischemia reperfusion. Invest Ophthalmol Vis Sci. 2011 Feb; 52(2):1035-42. PMID: 21051734; PMCID: PMC3053094.
    80. Kaneko H, Dridi S, Tarallo V, Gelfand BD, Fowler BJ, Cho WG, Kleinman ME, Ponicsan SL, Hauswirth WW, Chiodo VA, Karikó K, Yoo JW, Lee DK, Hadziahmetovic M, Song Y, Misra S, Chaudhuri G, Buaas FW, Braun RE, Hinton D, Zhang Q, Grossniklaus HE, Provis JM, Madigan MC, Milam AH, Justice NL, Albuquerque RJ, Blandford AD, Bogdanovich S, Hirano Y, Witta J, Fuchs E, Littman DR, Ambati BK, Rudin CM, Chong MM, Provost P, Kugel JF, Goodrich JA, Dunaief JL, Baffi JZ, Ambati J. DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature. 2011 Mar 17; 471(7338):325-30. PMID: 21297615.
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    82. Phares TW, Marques CP, Stohlman SA, Hinton D, Bergmann CC. Factors supporting intrathecal humoral responses following viral encephalomyelitis. J Virol. 2011 Mar; 85(6):2589-98. PMID: 21191015; PMCID: PMC3067923.
    83. Ye R, Mareninova OA, Barron E, Wang M, Hinton D, Pandol SJ, Lee AS. Grp78 heterozygosity regulates chaperone balance in exocrine pancreas with differential response to cerulein-induced acute pancreatitis. Am J Pathol. 2010 Dec; 177(6):2827-36. PMID: 20971738; PMCID: PMC2993313.
    84. Sreekumar PG, Kannan R, Kitamura M, Spee C, Barron E, Ryan SJ, Hinton D. aB crystallin is apically secreted within exosomes by polarized human retinal pigment epithelium and provides neuroprotection to adjacent cells. PLoS One. 2010 Oct 08; 5(10):e12578. PMID: 20949024; PMCID: PMC2951891.
    85. Gundimeda U, McNeill TH, Schiffman JE, Hinton D, Gopalakrishna R. Green tea polyphenols potentiate the action of nerve growth factor to induce neuritogenesis: possible role of reactive oxygen species. J Neurosci Res. 2010 Dec; 88(16):3644-55. PMID: 20936703; PMCID: PMC2965808.
    86. Lim JI, Spee C, Hinton D. A comparison of hypoxia-inducible factor-a in surgically excised neovascular membranes of patients with diabetes compared with idiopathic epiretinal membranes in nondiabetic patients. Retina. 2010 Oct; 30(9):1472-8. PMID: 20811317; PMCID: PMC3690285.
    87. Phares TW, Stohlman SA, Hinton D, Atkinson R, Bergmann CC. Enhanced antiviral T cell function in the absence of B7-H1 is insufficient to prevent persistence but exacerbates axonal bystander damage during viral encephalomyelitis. J Immunol. 2010 Nov 01; 185(9):5607-18. PMID: 20876353; PMCID: PMC3159959.
    88. Tran ND, Kim S, Vincent HK, Rodriguez A, Hinton D, Bullock MR, Young HF. Aquaporin-1-mediated cerebral edema following traumatic brain injury: effects of acidosis and corticosteroid administration. J Neurosurg. 2010 May; 112(5):1095-104. PMID: 19731985.
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    89. Hua J, Spee C, Kase S, Rennel ES, Magnussen AL, Qiu Y, Varey A, Dhayade S, Churchill AJ, Harper SJ, Bates DO, Hinton D. Recombinant human VEGF165b inhibits experimental choroidal neovascularization. Invest Ophthalmol Vis Sci. 2010 Aug; 51(8):4282-8. PMID: 20237252; PMCID: PMC2910649.
    90. Zhou J, He S, Zhang N, Spee C, Zhou P, Ryan SJ, Kannan R, Hinton D. Neutrophils compromise retinal pigment epithelial barrier integrity. J Biomed Biotechnol. 2010; 2010:289360. PMID: 20204129; PMCID: PMC2831460.
    91. Parra GI, Bergmann CC, Phares TW, Hinton D, Atkinson R, Stohlman SA. Gamma interferon signaling in oligodendrocytes is critical for protection from neurotropic coronavirus infection. J Virol. 2010 Mar; 84(6):3111-5. PMID: 20042510; PMCID: PMC2826048.
    92. Sonoda S, Sreekumar PG, Kase S, Spee C, Ryan SJ, Kannan R, Hinton D. Attainment of polarity promotes growth factor secretion by retinal pigment epithelial cells: relevance to age-related macular degeneration. Aging (Albany NY). 2009 Dec 27; 2(1):28-42. PMID: 20228934; PMCID: PMC2837203.
    93. Kase S, He S, Sonoda S, Kitamura M, Spee C, Wawrousek E, Ryan SJ, Kannan R, Hinton D. alphaB-crystallin regulation of angiogenesis by modulation of VEGF. Blood. 2010 Apr 22; 115(16):3398-406. PMID: 20023214; PMCID: PMC2858494.
    94. Ireland DD, Stohlman SA, Hinton D, Kapil P, Silverman RH, Atkinson RA, Bergmann CC. RNase L mediated protection from virus induced demyelination. PLoS Pathog. 2009 Oct; 5(10):e1000602. PMID: 19798426; PMCID: PMC2745574.
    95. Zhu D, Sreekumar PG, Hinton D, Kannan R. Expression and regulation of enzymes in the ceramide metabolic pathway in human retinal pigment epithelial cells and their relevance to retinal degeneration. Vision Res. 2010 Mar 31; 50(7):643-51. PMID: 19765607; PMCID: PMC2840213.
    96. He S, Kumar SR, Zhou P, Krasnoperov V, Ryan SJ, Gill PS, Hinton D. Soluble EphB4 inhibition of PDGF-induced RPE migration in vitro. Invest Ophthalmol Vis Sci. 2010 Jan; 51(1):543-52. PMID: 19696168; PMCID: PMC2828363.
    97. Zhu D, Deng X, Xu J, Hinton D. What determines the switch between atrophic and neovascular forms of age related macular degeneration? - the role of BMP4 induced senescence. Aging (Albany NY). 2009 Aug 12; 1(8):740-5. PMID: 20157553; PMCID: PMC2806048.
    98. Chothe PP, Thakkar SV, Gnana-Prakasam JP, Ananth S, Hinton D, Kannan R, Smith SB, Martin PM, Ganapathy V. Identification of a novel sodium-coupled oligopeptide transporter (SOPT2) in mouse and human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2010 Jan; 51(1):413-20. PMID: 19643969; PMCID: PMC3973186.
    99. Sadler TR, Khodavirdi AC, Hinton D, Holschneider DP. Snap-frozen brain tissue sections stored with desiccant at ambient laboratory conditions without chemical fixation are resistant to degradation for a minimum of 6 months. Appl Immunohistochem Mol Morphol. 2009 Mar; 17(2):165-71. PMID: 19521279; PMCID: PMC2742633.
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    101. Zhu D, Wu J, Spee C, Ryan SJ, Hinton D. BMP4 mediates oxidative stress-induced retinal pigment epithelial cell senescence and is overexpressed in age-related macular degeneration. J Biol Chem. 2009 Apr 03; 284(14):9529-39. PMID: 19158083; PMCID: PMC2666605.
    102. Sonoda S, Spee C, Barron E, Ryan SJ, Kannan R, Hinton D. A protocol for the culture and differentiation of highly polarized human retinal pigment epithelial cells. Nat Protoc. 2009; 4(5):662-73. PMID: 19373231; PMCID: PMC2688697.
    103. Ray A, Colodetti L, Weiland JD, Hinton D, Humayun MS, Lee EJ. Immunocytochemical analysis of retinal neurons under electrical stimulation. Brain Res. 2009 Feb 19; 1255:89-97. PMID: 19103179; PMCID: PMC2736682.
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    105. Savarin C, Bergmann CC, Hinton D, Ransohoff RM, Stohlman SA. Memory CD4+ T-cell-mediated protection from lethal coronavirus encephalomyelitis. J Virol. 2008 Dec; 82(24):12432-40. PMID: 18842712; PMCID: PMC2593339.
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    107. Lundberg P, Ramakrishna C, Brown J, Tyszka JM, Hamamura M, Hinton D, Kovats S, Nalcioglu O, Weinberg K, Openshaw H, Cantin EM. The immune response to herpes simplex virus type 1 infection in susceptible mice is a major cause of central nervous system pathology resulting in fatal encephalitis. J Virol. 2008 Jul; 82(14):7078-88. PMID: 18480436; PMCID: PMC2446972.
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    109. Sreekumar PG, Zhou J, Sohn J, Spee C, Ryan SJ, Maurer BJ, Kannan R, Hinton D. N-(4-hydroxyphenyl) retinamide augments laser-induced choroidal neovascularization in mice. Invest Ophthalmol Vis Sci. 2008 Mar; 49(3):1210-20. PMID: 18326751.
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    111. Stohlman SA, Hinton D, Parra B, Atkinson R, Bergmann CC. CD4 T cells contribute to virus control and pathology following central nervous system infection with neurotropic mouse hepatitis virus. J Virol. 2008 Mar; 82(5):2130-9. PMID: 18094171; PMCID: PMC2258904.
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    114. Yaung J, Jin M, Barron E, Spee C, Wawrousek EF, Kannan R, Hinton D. alpha-Crystallin distribution in retinal pigment epithelium and effect of gene knockouts on sensitivity to oxidative stress. Mol Vis. 2007 Apr 04; 13:566-77. PMID: 17438522; PMCID: PMC2652021.
    115. Tedeschi-Blok N, Buckley J, Varma R, Triche TJ, Hinton D. Population-based study of early age-related macular degeneration: role of the complement factor H Y402H polymorphism in bilateral but not unilateral disease. Ophthalmology. 2007 Jan; 114(1):99-103. PMID: 17198853.
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    116. Agrawal RN, He S, Spee C, Cui JZ, Ryan SJ, Hinton D. In vivo models of proliferative vitreoretinopathy. Nat Protoc. 2007; 2(1):67-77. PMID: 17401340.
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    117. Kannan R, Zhang N, Sreekumar PG, Spee CK, Rodriguez A, Barron E, Hinton D. Stimulation of apical and basolateral VEGF-A and VEGF-C secretion by oxidative stress in polarized retinal pigment epithelial cells. Mol Vis. 2006 Dec 22; 12:1649-59. PMID: 17200665.
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    119. Hindinger C, Hinton D, Kirwin SJ, Atkinson RD, Burnett ME, Bergmann CC, Stohlman SA. Liver X receptor activation decreases the severity of experimental autoimmune encephalomyelitis. J Neurosci Res. 2006 Nov 01; 84(6):1225-34. PMID: 16955483.
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    120. Kirwin SJ, Dowdell KC, Hindinger C, Feng N, Bergmann CC, Hinton D, Stohlman SA. Altered neuroantigen-specific cytokine secretion in a Th2 environment reduces experimental autoimmune encephalomyelitis. J Neuroimmunol. 2006 Sep; 178(1-2):30-9. PMID: 16814872.
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    121. Sreekumar PG, Kannan R, de Silva AT, Burton R, Ryan SJ, Hinton D. Thiol regulation of vascular endothelial growth factor-A and its receptors in human retinal pigment epithelial cells. Biochem Biophys Res Commun. 2006 Aug 11; 346(4):1200-6. PMID: 16793007.
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    122. Lutty GA, Chan-Ling T, Phelps DL, Adamis AP, Berns KI, Chan CK, Cole CH, D'Amore PA, Das A, Deng WT, Dobson V, Flynn JT, Friedlander M, Fulton A, Good WV, Grant MB, Hansen R, Hauswirth WW, Hardy RJ, Hinton D, Hughes S, McLeod DS, Palmer EA, Patz A, Penn JS, Raisler BJ, Repka MX, Saint-Geniez M, Shaw LC, Shima DT, Smith BT, Smith LE, Tahija SG, Tasman W, Trese MT. Proceedings of the Third International Symposium on Retinopathy of Prematurity: an update on ROP from the lab to the nursery (November 2003, Anaheim, California). Mol Vis. 2006 May 23; 12:532-80. PMID: 16735995.
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    123. Kramerov AA, Saghizadeh M, Pan H, Kabosova A, Montenarh M, Ahmed K, Penn JS, Chan CK, Hinton D, Grant MB, Ljubimov AV. Expression of protein kinase CK2 in astroglial cells of normal and neovascularized retina. Am J Pathol. 2006 May; 168(5):1722-36. PMID: 16651637; PMCID: PMC1606582.
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    125. Gamulescu MA, Chen Y, He S, Spee C, Jin M, Ryan SJ, Hinton D. Transforming growth factor beta2-induced myofibroblastic differentiation of human retinal pigment epithelial cells: regulation by extracellular matrix proteins and hepatocyte growth factor. Exp Eye Res. 2006 Jul; 83(1):212-22. PMID: 16563380.
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    126. González JM, Bergmann CC, Ramakrishna C, Hinton D, Atkinson R, Hoskin J, Macklin WB, Stohlman SA. Inhibition of interferon-gamma signaling in oligodendroglia delays coronavirus clearance without altering demyelination. Am J Pathol. 2006 Mar; 168(3):796-804. PMID: 16507895; PMCID: PMC1606538.
    127. Tschen SI, Stohlman SA, Ramakrishna C, Hinton D, Atkinson RD, Bergmann CC. CNS viral infection diverts homing of antibody-secreting cells from lymphoid organs to the CNS. Eur J Immunol. 2006 Mar; 36(3):603-12. PMID: 16437540.
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    128. Zuo J, Stohlman SA, Hoskin JB, Hinton D, Atkinson R, Bergmann CC. Mouse hepatitis virus pathogenesis in the central nervous system is independent of IL-15 and natural killer cells. Virology. 2006 Jun 20; 350(1):206-15. PMID: 16510164.
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    129. Zhang N, Kannan R, Okamoto CT, Ryan SJ, Lee VH, Hinton D. Characterization of brimonidine transport in retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2006 Jan; 47(1):287-94. PMID: 16384975.
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    130. He S, Ding Y, Zhou J, Krasnoperov V, Zozulya S, Kumar SR, Ryan SJ, Gill PS, Hinton D. Soluble EphB4 regulates choroidal endothelial cell function and inhibits laser-induced choroidal neovascularization. Invest Ophthalmol Vis Sci. 2005 Dec; 46(12):4772-9. PMID: 16303978.
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    131. Lim JI, Spee C, Hangai M, Rocha J, Ying HS, Ryan SJ, Hinton D. Neuropilin-1 expression by endothelial cells and retinal pigment epithelial cells in choroidal neovascular membranes. Am J Ophthalmol. 2005 Dec; 140(6):1044-1050. PMID: 16376649.
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    132. Hangai M, He S, Hoffmann S, Lim JI, Ryan SJ, Hinton D. Sequential induction of angiogenic growth factors by TNF-alpha in choroidal endothelial cells. J Neuroimmunol. 2006 Feb; 171(1-2):45-56. PMID: 16288810.
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    133. Jin M, Yaung J, Kannan R, He S, Ryan SJ, Hinton D. Hepatocyte growth factor protects RPE cells from apoptosis induced by glutathione depletion. Invest Ophthalmol Vis Sci. 2005 Nov; 46(11):4311-9. PMID: 16249513.
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    134. Pan J, Al-Dubaib M, Liao CP, Fujino Y, Hinton D, Hayes KA, Mathes LE, Roy-Burman P. In vivo expression of GFP transgene delivered via a replicating feline leukemia virus. Vet Microbiol. 2005 Oct 31; 110(3-4):181-95. PMID: 16143471.
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    135. Hindinger C, Gonzalez JM, Bergmann CC, Fuss B, Hinton D, Atkinson RD, Macklin WB, Stohlman SA. Astrocyte expression of a dominant-negative interferon-gamma receptor. J Neurosci Res. 2005 Oct 01; 82(1):20-31. PMID: 16118798.
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    136. Sreekumar PG, Kannan R, Yaung J, Spee CK, Ryan SJ, Hinton D. Protection from oxidative stress by methionine sulfoxide reductases in RPE cells. Biochem Biophys Res Commun. 2005 Aug 19; 334(1):245-53. PMID: 15993845.
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    137. González JM, Bergmann CC, Fuss B, Hinton D, Kangas C, Macklin WB, Stohlman SA. Expression of a dominant negative IFN-gammareceptor on mouse oligodendrocytes. Glia. 2005 Jul; 51(1):22-34. PMID: 15779088.
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    138. Hoffmann S, He S, Jin M, Ehren M, Wiedemann P, Ryan SJ, Hinton D. A selective cyclic integrin antagonist blocks the integrin receptors alphavbeta3 and alphavbeta5 and inhibits retinal pigment epithelium cell attachment, migration and invasion. BMC Ophthalmol. 2005 Jun 29; 5:16. PMID: 15987521; PMCID: PMC1184086.
    139. Zhou J, Pham L, Zhang N, He S, Gamulescu MA, Spee C, Ryan SJ, Hinton D. Neutrophils promote experimental choroidal neovascularization. Mol Vis. 2005 Jun 16; 11:414-24. PMID: 15988410.
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    140. Chan CK, Pham LN, Zhou J, Spee C, Ryan SJ, Hinton D. Differential expression of pro- and antiangiogenic factors in mouse strain-dependent hypoxia-induced retinal neovascularization. Lab Invest. 2005 Jun; 85(6):721-33. PMID: 15856049.
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    141. Zhou J, Marten NW, Bergmann CC, Macklin WB, Hinton D, Stohlman SA. Expression of matrix metalloproteinases and their tissue inhibitor during viral encephalitis. J Virol. 2005 Apr; 79(8):4764-73. PMID: 15795262; PMCID: PMC1069551.
    142. Güven D, Weiland JD, Fujii G, Mech BV, Mahadevappa M, Greenberg R, Roizenblatt R, Qiu G, Labree L, Wang X, Hinton D, Humayun MS. Long-term stimulation by active epiretinal implants in normal and RCD1 dogs. J Neural Eng. 2005 Mar; 2(1):S65-73. PMID: 15876657.
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    143. Zhou J, Hinton D, Stohlman SA, Liu CP, Zhong L, Marten NW. Maintenance of CD8+ T cells during acute viral infection of the central nervous system requires CD4+ T cells but not interleukin-2. Viral Immunol. 2005; 18(1):162-9. PMID: 15802960.
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    144. Ramakrishna C, Stohlman SA, Atkinson RA, Hinton D, Bergmann CC. Differential regulation of primary and secondary CD8+ T cells in the central nervous system. J Immunol. 2004 Nov 15; 173(10):6265-73. PMID: 15528365.
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    145. Kannan R, Jin M, Gamulescu MA, Hinton D. Ceramide-induced apoptosis: role of catalase and hepatocyte growth factor. Free Radic Biol Med. 2004 Jul 15; 37(2):166-75. PMID: 15203188.
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    146. Weiner LP, Louie KA, Atalla LR, Kochounian HH, Du J, Wei W, Hinton D, Gordon EM, Anderson WF, McMillan M. Gene therapy in a murine model for clinical application to multiple sclerosis. Ann Neurol. 2004 Mar; 55(3):390-9. PMID: 14991817.
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    147. Hinton D, Spee C, He S, Weitz S, Usinger W, LaBree L, Oliver N, Lim JI. Accumulation of NH2-terminal fragment of connective tissue growth factor in the vitreous of patients with proliferative diabetic retinopathy. Diabetes Care. 2004 Mar; 27(3):758-64. PMID: 14988298.
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    148. Chan CK, Pham LN, Chinn C, Spee C, Ryan SJ, Akhurst RJ, Hinton D. Mouse strain-dependent heterogeneity of resting limbal vasculature. Invest Ophthalmol Vis Sci. 2004 Feb; 45(2):441-7. PMID: 14744883.
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    149. Bergmann CC, Parra B, Hinton D, Ramakrishna C, Dowdell KC, Stohlman SA. Perforin and gamma interferon-mediated control of coronavirus central nervous system infection by CD8 T cells in the absence of CD4 T cells. J Virol. 2004 Feb; 78(4):1739-50. PMID: 14747539; PMCID: PMC369505.
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    151. Karanjawala ZE, Hinton D, Oh E, Hsieh CL, Lieber MR. Developmental retinal apoptosis in Ku86-/- mice. DNA Repair (Amst). 2003 Dec 09; 2(12):1429-34. PMID: 14642570.
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    152. He S, Jin ML, Worpel V, Hinton D. A role for connective tissue growth factor in the pathogenesis of choroidal neovascularization. Arch Ophthalmol. 2003 Sep; 121(9):1283-8. PMID: 12963611.
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    153. Wu LY, Li M, Hinton D, Guo L, Jiang S, Wang JT, Zeng A, Xie JB, Snead M, Shuler C, Maxson RE, Liu YH. Microphthalmia resulting from MSX2-induced apoptosis in the optic vesicle. Invest Ophthalmol Vis Sci. 2003 Jun; 44(6):2404-12. PMID: 12766037.
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    154. Bergmann CC, Parra B, Hinton D, Chandran R, Morrison M, Stohlman SA. Perforin-mediated effector function within the central nervous system requires IFN-gamma-mediated MHC up-regulation. J Immunol. 2003 Mar 15; 170(6):3204-13. PMID: 12626579.
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    155. Zhou J, Stohlman SA, Hinton D, Marten NW. Neutrophils promote mononuclear cell infiltration during viral-induced encephalitis. J Immunol. 2003 Mar 15; 170(6):3331-6. PMID: 12626593.
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    156. Stohlman SA, Ramakrishna C, Tschen SI, Hinton D, Bergmann CC. The art of survival during viral persistence. J Neurovirol. 2002 Dec; 8 Suppl 2:53-8. PMID: 12491152.
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    157. Simard M, Zhang W, Hinton D, Chen TC, Weiss MH, Su YZ, Gopalakrishna R, Law RE, Couldwell WT. Tamoxifen-induced growth arrest and apoptosis in pituitary tumor cells in vitro via a protein kinase C-independent pathway. Cancer Lett. 2002 Nov 28; 185(2):131-8. PMID: 12169386.
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    158. Zhou J, Stohlman SA, Atkinson R, Hinton D, Marten NW. Matrix metalloproteinase expression correlates with virulence following neurotropic mouse hepatitis virus infection. J Virol. 2002 Aug; 76(15):7374-84. PMID: 12097550; PMCID: PMC136378.
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    160. Karanjawala ZE, Murphy N, Hinton D, Hsieh CL, Lieber MR. Oxygen metabolism causes chromosome breaks and is associated with the neuronal apoptosis observed in DNA double-strand break repair mutants. Curr Biol. 2002 Mar 05; 12(5):397-402. PMID: 11882291.
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    161. Ryan SJ, Hinton D, Ogden TE, Rao N. Translational research in ophthalmology. Arch Ophthalmol. 2002 Mar; 120(3):389-90. PMID: 11879146.
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