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Danieli B. Salinas, MD

TitleAssistant Professor of Clinical Pediatrics
InstitutionUniversity of Southern California
DepartmentPediatrics
Phone+1 323 361 2101
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    I am originally from Rio de Janeiro, Brazil and I came to the U.S. for Residency and Fellowship training in Pediatric Pulmonology with the goal of becoming a physician scientist. My passion is Cystic Fibrosis. I enjoy taking care of these complex children and I am fascinated by the science behind the consequences of this defective chloride channel. The fact that we still don’t have a cure for this disease and that there are nearly 2,000 different mutations producing a wide range of clinical presentations are my biggest motivation to work in this field. I hope to make contributions to improve the lives of people with this disease and I hope I can one day say CF stands for Cure Found! My major areas of research interest are predicting clinical outcomes in children with a positive newborn screening for Cystic Fibrosis.
    a. Retrospective study based on the California database.
    b. Hierarchical modeling of clinical prediction.
    c. Developing a Sweat Rate test for infants for more accurately diagnose CF and predict clinical outcome.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Foil KE, Powers A, Raraigh KS, Wallis K, Southern KW, Salinas D. The increasing challenge of genetic counseling for cystic fibrosis. J Cyst Fibros. 2018 Dec 07. PMID: 30527892.
      View in: PubMed
    2. Salinas DB, Kang L, Azen C, Quinton P. Low Beta-Adrenergic Sweat Responses in Cystic Fibrosis and Cystic Fibrosis Transmembrane Conductance Regulator-Related Metabolic Syndrome Children. Pediatr Allergy Immunol Pulmonol. 2017 Mar 01; 30(1):2-6. PMID: 28465863.
      View in: PubMed
    3. Sosnay PR, Salinas DB, White TB, Ren CL, Farrell PM, Raraigh KS, Girodon E, Castellani C. Applying Cystic Fibrosis Transmembrane Conductance Regulator Genetics and CFTR2 Data to Facilitate Diagnoses. J Pediatr. 2017 Feb; 181S:S27-S32.e1. PMID: 28129809.
      View in: PubMed
    4. Salinas DB, Azen C, Young S, Keens TG, Kharrazi M, Parad RB. Phenotypes of California CF Newborn Screen-Positive Children with CFTR 5T Allele by TG Repeat Length. Genet Test Mol Biomarkers. 2016 Sep; 20(9):496-503. PMID: 27447098.
      View in: PubMed
    5. Salinas DB, Sosnay PR, Azen C, Young S, Raraigh KS, Keens TG, Kharrazi M. Benign and Deleterious Cystic Fibrosis Transmembrane Conductance Regulator Mutations Identified by Sequencing in Positive Cystic Fibrosis Newborn Screen Children from California. PLoS One. 2016; 11(5):e0155624. PMID: 27214204; PMCID: PMC4877015.
    6. Salinas DB, Sosnay PR, Azen C, Young S, Raraigh KS, Keens TG, Kharrazi M. Benign outcome among positive cystic fibrosis newborn screen children with non-CF-causing variants. J Cyst Fibros. 2015 Nov; 14(6):714-9. PMID: 25824995; PMCID: PMC4587349 [Available on 11/01/16].
    7. Prach L, Koepke R, Kharrazi M, Keiles S, Salinas DB, Reyes MC, Pian M, Opsimos H, Otsuka KN, Hardy KA, Milla CE, Zirbes JM, Chipps B, O'Bra S, Saeed MM, Sudhakar R, Lehto S, Nielson D, Shay GF, Seastrand M, Jhawar S, Nickerson B, Landon C, Thompson A, Nussbaum E, Chin T, Wojtczak H. Novel CFTR variants identified during the first 3 years of cystic fibrosis newborn screening in California. J Mol Diagn. 2013 Sep; 15(5):710-22. PMID: 23810505.
      View in: PubMed
    8. Song Y, Salinas D, Nielson DW, Verkman AS. Hyperacidity of secreted fluid from submucosal glands in early cystic fibrosis. Am J Physiol Cell Physiol. 2006 Mar; 290(3):C741-9. PMID: 16207791.
      View in: PubMed
    9. Salinas D, Haggie PM, Thiagarajah JR, Song Y, Rosbe K, Finkbeiner WE, Nielson DW, Verkman AS. Submucosal gland dysfunction as a primary defect in cystic fibrosis. FASEB J. 2005 Mar; 19(3):431-3. PMID: 15596485.
      View in: PubMed
    10. Muanprasat C, Sonawane ND, Salinas D, Taddei A, Galietta LJ, Verkman AS. Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy. J Gen Physiol. 2004 Aug; 124(2):125-37. PMID: 15277574; PMCID: PMC2229623.
    11. Song Y, Sonawane ND, Salinas D, Qian L, Pedemonte N, Galietta LJ, Verkman AS. Evidence against the rescue of defective DeltaF508-CFTR cellular processing by curcumin in cell culture and mouse models. J Biol Chem. 2004 Sep 24; 279(39):40629-33. PMID: 15280357.
      View in: PubMed
    12. Salinas DB, Pedemonte N, Muanprasat C, Finkbeiner WF, Nielson DW, Verkman AS. CFTR involvement in nasal potential differences in mice and pigs studied using a thiazolidinone CFTR inhibitor. Am J Physiol Lung Cell Mol Physiol. 2004 Nov; 287(5):L936-43. PMID: 15246976.
      View in: PubMed