Loading...
Sign in to edit your profile (add interests, mentoring, photo, etc.)

    Dan Ruderman, PhD

    TitleAssistant Professor of Research Medicine
    SchoolKeck School of Medicine of USC
    DepartmentMedicine
    AddressCSC 2250 Biggy St. Ste. 240
    Health Sciences Campus
    Los Angeles California 90033
    Phone+1 323 442 2839
    Emailruderman@usc.edu
    vCardDownload vCard

      Collapse Overview 
      Collapse Overview
      Dan Ruderman received his doctorate in theoretical physics from the University of California at Berkeley, followed by postdoctoral research at Cambridge University, USC, and the Salk Institute. Dr. Ruderman continued his scientific research in the industrial setting, first in solid tumor target discovery through integrative genomics at Berlex Biosciences, and then in proteomic biomarker discovery at Applied Minds.

      He was Founding Scientist at Applied Proteomics, a biomarker company spun out from Applied Minds in 2007. Dr. Ruderman joined CAMM in 2011, where his research focuses on signaling dynamics in cancer cells and systems biology interpretations of high-dimensional cancer assays, such as gene expression, proteomics, and autoantibodies.


      Collapse Biography 
      Collapse Awards and Honors
      Phi Beta Kappa1988Elected Member
      1988President's Undergraduate Fellowship
      Fannie and John Hertz Foundation 1989  - 1993Fellowship
      National Science Foundation1993Fellowship
      National Science Foundation/ North Atlantic Treaty Organization1994Postdoctoral Fellowship
      Sloan Foundation1996  - 1998Postdoctoral Fellowship

      Collapse ORNG Applications 
      Collapse Websites
      Collapse Twitter

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Ruderman D. The emergence of dynamic phenotyping. Cell Biol Toxicol. 2017 Sep 23. PMID: 28942588.
        View in: PubMed
      2. Ruderman D. Designing Successful Proteomics Experiments. Methods Mol Biol. 2017; 1550:271-288. PMID: 28188536.
        View in: PubMed
      3. Patsch K, Chiu CL, Engeln M, Agus DB, Mallick P, Mumenthaler SM, Ruderman D. Single cell dynamic phenotyping. Sci Rep. 2016 Oct 06; 6:34785. PMID: 27708391.
        View in: PubMed
      4. Flinders C, Lam L, Rubbi L, Ferrari R, Fitz-Gibbon S, Chen PY, Thompson M, Christofk H, B Agus D, Ruderman D, Mallick P, Pellegrini M. Epigenetic changes mediated by polycomb repressive complex 2 and E2a are associated with drug resistance in a mouse model of lymphoma. Genome Med. 2016 05 04; 8(1):54. PMID: 27146673; PMCID: PMC4857420.
      5. Chiu CL, Patsch K, Cutrale F, Soundararajan A, Agus DB, Fraser SE, Ruderman D. Intracellular kinetics of the androgen receptor shown by multimodal Image Correlation Spectroscopy (mICS). Sci Rep. 2016 Mar 03; 6:22435. PMID: 26936218; PMCID: PMC4776155.
      6. Chambers MC, Maclean B, Burke R, Amodei D, Ruderman D, Neumann S, Gatto L, Fischer B, Pratt B, Egertson J, Hoff K, Kessner D, Tasman N, Shulman N, Frewen B, Baker TA, Brusniak MY, Paulse C, Creasy D, Flashner L, Kani K, Moulding C, Seymour SL, Nuwaysir LM, Lefebvre B, Kuhlmann F, Roark J, Rainer P, Detlev S, Hemenway T, Huhmer A, Langridge J, Connolly B, Chadick T, Holly K, Eckels J, Deutsch EW, Moritz RL, Katz JE, Agus DB, MacCoss M, Tabb DL, Mallick P. A cross-platform toolkit for mass spectrometry and proteomics. Nat Biotechnol. 2012 Oct; 30(10):918-20. PMID: 23051804; PMCID: PMC3471674.
      7. Kani K, Malihi PD, Jiang Y, Wang H, Wang Y, Ruderman D, Agus DB, Mallick P, Gross ME. Anterior gradient 2 (AGR2): blood-based biomarker elevated in metastatic prostate cancer associated with the neuroendocrine phenotype. Prostate. 2013 Feb 15; 73(3):306-15. PMID: 22911164.
        View in: PubMed
      8. Hughey CA, Minardi CS, Galasso-Roth SA, Paspalof GB, Mapolelo MM, Rodgers RP, Marshall AG, Ruderman D. Naphthenic acids as indicators of crude oil biodegradation in soil, based on semi-quantitative electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry. Rapid Commun Mass Spectrom. 2008 Dec; 22(23):3968-76. PMID: 19003816.
        View in: PubMed
      9. Yamaguchi KD, Ruderman D, Croze E, Wagner TC, Velichko S, Reder AT, Salamon H. IFN-beta-regulated genes show abnormal expression in therapy-naïve relapsing-remitting MS mononuclear cells: gene expression analysis employing all reported protein-protein interactions. J Neuroimmunol. 2008 Mar; 195(1-2):116-20. PMID: 18279974.
        View in: PubMed
      10. Tedesco D, Zhang J, Trinh L, Lalehzadeh G, Meisner R, Yamaguchi KD, Ruderman D, Dinter H, Zajchowski DA. The ubiquitin-conjugating enzyme E2-EPF is overexpressed in primary breast cancer and modulates sensitivity to topoisomerase II inhibition. Neoplasia. 2007 Jul; 9(7):601-13. PMID: 17710163; PMCID: PMC1939933.
      11. Mel BW, Ruderman D, Archie KA. Translation-invariant orientation tuning in visual "complex" cells could derive from intradendritic computations. J Neurosci. 1998 Jun 01; 18(11):4325-34. PMID: 9592109.
        View in: PubMed