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Dan Ruderman, PhD

TitleAssistant Professor of Research Medicine
InstitutionUniversity of Southern California
DepartmentProvost - Ellison Institute
AddressCSC 2250 Biggy St. Ste. 240
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 2839
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    Collapse Biography 
    Collapse Education and Training
    University of California, BerkeleyB.S.05/1989Physics
    University of California , BerkeleyPh.D.10/1993Physics
    Cambridge University, Cambridge, UKPostdoctoral10/1995Visual neuroscience
    USCPostdoctoral10/1996Visual neuroscience
    The Salk Institute, La Jolla, CAPostdoctoral8/1998Visual neuroscience
    Collapse Awards and Honors
    Phi Beta Kappa1988Elected Member, Junior year
    U.C. Berkeley1988President's Undergraduate Fellowship
    Fannie and John Hertz Foundation 1989  - 1993Fellowship
    National Science Foundation1993Fellowship
    National Science Foundation/ North Atlantic Treaty Organization1994Postdoctoral Fellowship
    Alfred E. Sloan Foundation1996  - 1998Postdoctoral Fellowship

    Collapse Overview 
    Collapse Overview
    Dan Ruderman received his doctorate in theoretical physics from the University of California at Berkeley, followed by postdoctoral research at Cambridge University, USC, and the Salk Institute. Dr. Ruderman continued his scientific research in the industrial setting, first in solid tumor target discovery through integrative genomics at Berlex Biosciences, and then in proteomic biomarker discovery at Applied Minds.

    He was Founding Scientist at Applied Proteomics, a biomarker company spun out from Applied Minds in 2007. Dr. Ruderman joined CAMM in 2011, where his research focuses on signaling dynamics in cancer cells and systems biology interpretations of high-dimensional cancer assays, such as gene expression, proteomics, and autoantibodies.


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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Rawat RR, Ruderman D, Macklin P, Rimm DL, Agus DB. Correlating nuclear morphometric patterns with estrogen receptor status in breast cancer pathologic specimens. NPJ Breast Cancer. 2018; 4:32. PMID: 30211313.
      View in: PubMed
    2. Chiang CT, Demetriou AN, Ung N, Choudhury N, Ghaffarian K, Ruderman DL, Mumenthaler SM. mTORC2 contributes to the metabolic reprogramming in EGFR tyrosine-kinase inhibitor resistant cells in non-small cell lung cancer. Cancer Lett. 2018 Jul 20. PMID: 30036610.
      View in: PubMed
    3. Patsch K, Mumenthaler SM, Ruderman D. Image-Based Tracking of Heterogeneous Single-Cell Phenotypes. Methods Mol Biol. 2018; 1745:47-63. PMID: 29476462.
      View in: PubMed
    4. Ruderman D. The emergence of dynamic phenotyping. Cell Biol Toxicol. 2017 Dec; 33(6):507-509. PMID: 28942588.
      View in: PubMed
    5. Ruderman D. Designing Successful Proteomics Experiments. Methods Mol Biol. 2017; 1550:271-288. PMID: 28188536.
      View in: PubMed
    6. Patsch K, Chiu CL, Engeln M, Agus DB, Mallick P, Mumenthaler SM, Ruderman D. Single cell dynamic phenotyping. Sci Rep. 2016 Oct 06; 6:34785. PMID: 27708391.
      View in: PubMed
    7. Flinders C, Lam L, Rubbi L, Ferrari R, Fitz-Gibbon S, Chen PY, Thompson M, Christofk H, B Agus D, Ruderman D, Mallick P, Pellegrini M. Epigenetic changes mediated by polycomb repressive complex 2 and E2a are associated with drug resistance in a mouse model of lymphoma. Genome Med. 2016 05 04; 8(1):54. PMID: 27146673; PMCID: PMC4857420.
    8. Chiu CL, Patsch K, Cutrale F, Soundararajan A, Agus DB, Fraser SE, Ruderman D. Intracellular kinetics of the androgen receptor shown by multimodal Image Correlation Spectroscopy (mICS). Sci Rep. 2016 Mar 03; 6:22435. PMID: 26936218; PMCID: PMC4776155.
    9. Chambers MC, Maclean B, Burke R, Amodei D, Ruderman DL, Neumann S, Gatto L, Fischer B, Pratt B, Egertson J, Hoff K, Kessner D, Tasman N, Shulman N, Frewen B, Baker TA, Brusniak MY, Paulse C, Creasy D, Flashner L, Kani K, Moulding C, Seymour SL, Nuwaysir LM, Lefebvre B, Kuhlmann F, Roark J, Rainer P, Detlev S, Hemenway T, Huhmer A, Langridge J, Connolly B, Chadick T, Holly K, Eckels J, Deutsch EW, Moritz RL, Katz JE, Agus DB, MacCoss M, Tabb DL, Mallick P. A cross-platform toolkit for mass spectrometry and proteomics. Nat Biotechnol. 2012 Oct; 30(10):918-20. PMID: 23051804; PMCID: PMC3471674.
    10. Kani K, Malihi PD, Jiang Y, Wang H, Wang Y, Ruderman DL, Agus DB, Mallick P, Gross ME. Anterior gradient 2 (AGR2): blood-based biomarker elevated in metastatic prostate cancer associated with the neuroendocrine phenotype. Prostate. 2013 Feb 15; 73(3):306-15. PMID: 22911164.
      View in: PubMed
    11. Hughey CA, Minardi CS, Galasso-Roth SA, Paspalof GB, Mapolelo MM, Rodgers RP, Marshall AG, Ruderman DL. Naphthenic acids as indicators of crude oil biodegradation in soil, based on semi-quantitative electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry. Rapid Commun Mass Spectrom. 2008 Dec; 22(23):3968-76. PMID: 19003816.
      View in: PubMed
    12. Yamaguchi KD, Ruderman DL, Croze E, Wagner TC, Velichko S, Reder AT, Salamon H. IFN-beta-regulated genes show abnormal expression in therapy-naïve relapsing-remitting MS mononuclear cells: gene expression analysis employing all reported protein-protein interactions. J Neuroimmunol. 2008 Mar; 195(1-2):116-20. PMID: 18279974.
      View in: PubMed
    13. Tedesco D, Zhang J, Trinh L, Lalehzadeh G, Meisner R, Yamaguchi KD, Ruderman DL, Dinter H, Zajchowski DA. The ubiquitin-conjugating enzyme E2-EPF is overexpressed in primary breast cancer and modulates sensitivity to topoisomerase II inhibition. Neoplasia. 2007 Jul; 9(7):601-13. PMID: 17710163; PMCID: PMC1939933.
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