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Christianne Norton Heck, MD, MMM

TitleProfessor of Clinical Neurology
InstitutionUniversity of Southern California
DepartmentNeurology
AddressHCC 3rd Floor Room 3000
Health Sciences Campus
Los Angeles CA 90089-9405
Phone+1 323 442 8364
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    Other Positions
    TitleCo-Director, USC Center for Neurorestoration

    TitleMedical Director, USC Comprehensive Epilepsy Center


    Collapse Overview 
    Collapse Overview
    Dr. Heck serves as the Medical Director of the USC Comprehensive Epilepsy Program at the Keck Medical Center in Los Angeles. She served as Chief of Staff at Keck Hospitals of USC from 2015-2017, and serves as Co-Director for the USC Neurorestoration Center. She is board certified in both neurology and epilepsy. She is a member of the professional advisory board of the Epilepsy Foundation and has served on the Board of Directors of the National Association of Epilepsy Centers (NAECs). From 2011-12, she served on the Institute of Medicine's Committee on the Public Health Dimensions of the Epilepsies assisting in the writing of Epilepsy Across the Spectrum: Promoting Health and Understanding. She has been a member of the Association of California Neurologists Board of Directors, where she actively participated in opinions and discussions regarding patient care and access to care within the state of California. She volunteers regularly for Hollywood Health and Society of the USC Annenberg School of Communications Norman Lear Center whose goals are the promotion and evaluation of public health topics in film and television. Her research focuses on innovative approaches to treating epilepsy, including responsive neurostimulation and paradigms for optimizing neuromodulatory therapies, vagus nerve stimulation, epilepsy surgery and Gamma Knife radiosurgery. Her expertise also includes services to minority populations as well as furthering understanding of status epilepticus, neuronal injury, memory dysfunction, brain machine interfaces and the psychosocial impact of epilepsy. She is keenly interested in quality and access to care for epilepsy patients and families across the nation.


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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lee B, Kramer D, Armenta Salas M, Kellis S, Brown D, Dobreva T, Klaes C, Heck C, Liu C, Andersen RA. Engineering Artificial Somatosensation Through Cortical Stimulation in Humans. Front Syst Neurosci. 2018; 12:24. PMID: 29915532.
      View in: PubMed
    2. Smith JAD, Armacost M, Ensign E, Shaw S, Jimenez N, Millett D, Liu C, Heck C. Epilepsy surgery in the underserved Hispanic population improves depression, anxiety, and quality of life. Epilepsy Behav. 2018 Apr 06; 83:1-6. PMID: 29631155.
      View in: PubMed
    3. Barbaro NM, Quigg M, Ward MM, Chang EF, Broshek DK, Langfitt JT, Yan G, Laxer KD, Cole AJ, Sneed PK, Hess CP, Yu W, Tripathi M, Heck C, Miller JW, Garcia PA, McEvoy A, Fountain NB, Salanova V, Knowlton RC, Bagic A, Henry T, Kapoor S, McKhann G, Palade AE, Reuber M, Tecoma E. Radiosurgery versus open surgery for mesial temporal lobe epilepsy: The randomized, controlled ROSE trial. Epilepsia. 2018 Mar 30. PMID: 29600809.
      View in: PubMed
    4. Pierson NS, Kramer DR, Wen T, Ho L, Patel A, Donoho D, Mehta V, Heck C, Lee B, Mack WJ, Liu CY. Preventable complications in epilepsy admissions: The "July effect". Epilepsy Res. 2017 Nov; 137:101-106. PMID: 28985613.
      View in: PubMed
    5. Wen T, Kramer DR, Sirot S, Ho L, Moalem AS, Cen SY, Millett D, Heck C, Robison RA, Mack WJ, Liu CY. The Weekend Effect on Morbidity and Mortality Among Pediatric Epilepsy Admissions. Pediatr Neurol. 2017 Sep; 74:24-31.e1. PMID: 28676248.
      View in: PubMed
    6. Ho L, Kramer DR, Wen T, Moalem AS, Millett D, Heck C, Mack WJ, Liu CY. Potentially preventable complications in epilepsy admissions: The "weekend effect". Epilepsy Behav. 2017 05; 70(Pt A):50-56. PMID: 28410465.
      View in: PubMed
    7. Geller EB, Skarpaas TL, Gross RE, Goodman RR, Barkley GL, Bazil CW, Berg MJ, Bergey GK, Cash SS, Cole AJ, Duckrow RB, Edwards JC, Eisenschenk S, Fessler J, Fountain NB, Goldman AM, Gwinn RP, Heck C, Herekar A, Hirsch LJ, Jobst BC, King-Stephens D, Labar DR, Leiphart JW, Marsh WR, Meador KJ, Mizrahi EM, Murro AM, Nair DR, Noe KH, Park YD, Rutecki PA, Salanova V, Sheth RD, Shields DC, Skidmore C, Smith MC, Spencer DC, Srinivasan S, Tatum W, Van Ness PC, Vossler DG, Wharen RE, Worrell GA, Yoshor D, Zimmerman RS, Cicora K, Sun FT, Morrell MJ. Brain-responsive neurostimulation in patients with medically intractable mesial temporal lobe epilepsy. Epilepsia. 2017 06; 58(6):994-1004. PMID: 28398014.
      View in: PubMed
    8. Jobst BC, Kapur R, Barkley GL, Bazil CW, Berg MJ, Bergey GK, Boggs JG, Cash SS, Cole AJ, Duchowny MS, Duckrow RB, Edwards JC, Eisenschenk S, Fessler AJ, Fountain NB, Geller EB, Goldman AM, Goodman RR, Gross RE, Gwinn RP, Heck C, Herekar AA, Hirsch LJ, King-Stephens D, Labar DR, Marsh WR, Meador KJ, Miller I, Mizrahi EM, Murro AM, Nair DR, Noe KH, Olejniczak PW, Park YD, Rutecki P, Salanova V, Sheth RD, Skidmore C, Smith MC, Spencer DC, Srinivasan S, Tatum W, Van Ness P, Vossler DG, Wharen RE, Worrell GA, Yoshor D, Zimmerman RS, Skarpaas TL, Morrell MJ. Brain-responsive neurostimulation in patients with medically intractable seizures arising from eloquent and other neocortical areas. Epilepsia. 2017 06; 58(6):1005-1014. PMID: 28387951.
      View in: PubMed
    9. Liu C, Russin J, Heck C, Kawata K, Adiga R, Yen W, Lambert J, Stear B, Law M, Marquez Y, Crino P, Millett D, Langford D. Dysregulation of PINCH signaling in mesial temporal epilepsy. J Clin Neurosci. 2017 Feb; 36:43-52. PMID: 27838154.
      View in: PubMed
    10. A sparse Laguerre-Volterra autoregressive model for seizure prediction in temporal lobe epilepsy. Conf Proc IEEE Eng Med Biol Soc. 2016 08; 2016:1664-1667. PMID: 28324947.
      View in: PubMed
    11. Klaes C, Kellis S, Aflalo T, Lee B, Pejsa K, Shanfield K, Hayes-Jackson S, Aisen M, Heck C, Liu C, Andersen RA. Hand Shape Representations in the Human Posterior Parietal Cortex. J Neurosci. 2015 Nov 18; 35(46):15466-76. PMID: 26586832; PMCID: PMC4649012.
    12. Nune G, DeGiorgio C, Heck C. Neuromodulation in the Treatment of Epilepsy. Curr Treat Options Neurol. 2015 Oct; 17(10):375. PMID: 26307329.
      View in: PubMed
    13. Aflalo T, Kellis S, Klaes C, Lee B, Shi Y, Pejsa K, Shanfield K, Hayes-Jackson S, Aisen M, Heck C, Liu C, Andersen RA. Neurophysiology. Decoding motor imagery from the posterior parietal cortex of a tetraplegic human. Science. 2015 May 22; 348(6237):906-10. PMID: 25999506; PMCID: PMC4896830.
    14. King-Stephens D, Mirro E, Weber PB, Laxer KD, Van Ness PC, Salanova V, Spencer DC, Heck C, Goldman A, Jobst B, Shields DC, Bergey GK, Eisenschenk S, Worrell GA, Rossi MA, Gross RE, Cole AJ, Sperling MR, Nair DR, Gwinn RP, Park YD, Rutecki PA, Fountain NB, Wharen RE, Hirsch LJ, Miller IO, Barkley GL, Edwards JC, Geller EB, Berg MJ, Sadler TL, Sun FT, Morrell MJ. Lateralization of mesial temporal lobe epilepsy with chronic ambulatory electrocorticography. Epilepsia. 2015 Jun; 56(6):959-67. PMID: 25988840; PMCID: PMC4676303.
    15. Lee B, Zubair MN, Marquez YD, Lee DM, Kalayjian LA, Heck C, Liu CY. A Single-Center Experience with the NeuroPace RNS System: A Review of Techniques and Potential Problems. World Neurosurg. 2015 Sep; 84(3):719-26. PMID: 25940211.
      View in: PubMed
    16. Bergey GK, Morrell MJ, Mizrahi EM, Goldman A, King-Stephens D, Nair D, Srinivasan S, Jobst B, Gross RE, Shields DC, Barkley G, Salanova V, Olejniczak P, Cole A, Cash SS, Noe K, Wharen R, Worrell G, Murro AM, Edwards J, Duchowny M, Spencer D, Smith M, Geller E, Gwinn R, Skidmore C, Eisenschenk S, Berg M, Heck C, Van Ness P, Fountain N, Rutecki P, Massey A, O'Donovan C, Labar D, Duckrow RB, Hirsch LJ, Courtney T, Sun FT, Seale CG. Long-term treatment with responsive brain stimulation in adults with refractory partial seizures. Neurology. 2015 Feb 24; 84(8):810-7. PMID: 25616485; PMCID: PMC4339127.
    17. Soss J, Heck C, Murray D, Markovic D, Oviedo S, Corrale-Leyva G, Gordon S, Kealey C, DeGiorgio C. A prospective long-term study of external trigeminal nerve stimulation for drug-resistant epilepsy. Epilepsy Behav. 2015 Jan; 42:44-7. PMID: 25499162.
      View in: PubMed
    18. Hsiao MC, Yu PN, Song D, Liu CY, Heck C, Millett D, Berger TW. An in vitro seizure model from human hippocampal slices using multi-electrode arrays. J Neurosci Methods. 2015 Apr 15; 244:154-63. PMID: 25244953.
      View in: PubMed
    19. Heck C, King-Stephens D, Massey AD, Nair DR, Jobst BC, Barkley GL, Salanova V, Cole AJ, Smith MC, Gwinn RP, Skidmore C, Van Ness PC, Bergey GK, Park YD, Miller I, Geller E, Rutecki PA, Zimmerman R, Spencer DC, Goldman A, Edwards JC, Leiphart JW, Wharen RE, Fessler J, Fountain NB, Worrell GA, Gross RE, Eisenschenk S, Duckrow RB, Hirsch LJ, Bazil C, O'Donovan CA, Sun FT, Courtney TA, Seale CG, Morrell MJ. Two-year seizure reduction in adults with medically intractable partial onset epilepsy treated with responsive neurostimulation: final results of the RNS System Pivotal trial. Epilepsia. 2014 Mar; 55(3):432-41. PMID: 24621228; PMCID: PMC4233950.
    20. Unstable periodic orbits in human epileptic hippocampal slices. Conf Proc IEEE Eng Med Biol Soc. 2014; 2014:5800-3. PMID: 25571314.
      View in: PubMed
    21. A testbed to explore the optimal electrical stimulation parameters for suppressing inter-ictal spikes in human hippocampal slices. Conf Proc IEEE Eng Med Biol Soc. 2014; 2014:5792-5. PMID: 25571312.
      View in: PubMed
    22. Hensley-Judge H, Quigg M, Barbaro NM, Newman SA, Ward MM, Chang EF, Broshek DK, Lamborn KR, Laxer KD, Garcia P, Heck C, Kondziolka D, Beach R, Salanova V, Goodman R. Visual field defects after radiosurgery for mesial temporal lobe epilepsy. Epilepsia. 2013 Aug; 54(8):1376-80. PMID: 23663063.
      View in: PubMed
    23. DeGiorgio CM, Soss J, Cook IA, Markovic D, Gornbein J, Murray D, Oviedo S, Gordon S, Corralle-Leyva G, Kealey CP, Heck C. Randomized controlled trial of trigeminal nerve stimulation for drug-resistant epilepsy. Neurology. 2013 Feb 26; 80(9):786-91. PMID: 23365066; PMCID: PMC3598453.
    24. Berger T, Song D, Chan R, Shin D, Marmarelis V, Hampson R, Sweatt A, Heck C, Liu C, Wills J, Lacoss J, Granacki J, Gerhardt G, Deadwyler S. Role of the hippocampus in memory formation: restorative encoding memory integration neural device as a cognitive neural prosthesis. IEEE Pulse. 2012 Sep-Oct; 3(5):17-22. PMID: 23014702.
      View in: PubMed
    25. Hsiao MC, Yu PN, Song D, Liu CY, Heck C, Millett D, Berger TW. Spatio-temporal inter-ictal activity recorded from human epileptic hippocampal slices. Conf Proc IEEE Eng Med Biol Soc. 2012; 2012:5166-9. PMID: 23367092.
      View in: PubMed
    26. Herzog AG, Fowler KM, Sperling MR, Liporace JD, Kalayjian LA, Heck C, Krauss GL, Dworetzky BA, Pennell PB. Variation of seizure frequency with ovulatory status of menstrual cycles. Epilepsia. 2011 Oct; 52(10):1843-8. PMID: 21756250; PMCID: PMC4572701.
    27. Herzog AG, Smithson SD, Fowler KM, Krishnamurthy KB, Sundstrom D, Kalayjian LA, Heck C, Oviedo S, Correl-Leyva G, Garcia E, Gleason KA, Dworetzky BA. Premenstrual dysphoric disorder in women with epilepsy: relationships to potential epileptic, antiepileptic drug, and reproductive endocrine factors. Epilepsy Behav. 2011 Aug; 21(4):391-6. PMID: 21724471.
      View in: PubMed
    28. Heck C, Kunst M, Härtel K, Hülsmann S, Heinrich R. In vivo labeling and in vitro characterisation of central complex neurons involved in the control of sound production. J Neurosci Methods. 2009 Oct 15; 183(2):202-12. PMID: 19583981.
      View in: PubMed
    29. Heck C, Helmers SL, DeGiorgio CM. Vagus nerve stimulation therapy, epilepsy, and device parameters: scientific basis and recommendations for use. Neurology. 2002 Sep 24; 59(6 Suppl 4):S31-7. PMID: 12270966.
      View in: PubMed