Chengyu Liang, MD, PhD

Title(s)Associate Professor of Molecular Microbiology & Immunology
SchoolKeck School of Medicine of USC
Phone+1 323 442 7840
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    Collapse Overview 
    Collapse Overview
    Research in my lab is centered on understanding the basic principle of cellular processes including apoptosis and autophagy, cell cycle regulation and genomic stability, as well as intracellular trafficking matrix in the development of cancer and infectious disease. Being a lysosome-dependent quality control mechanism and house-cleaning activity of the cessll, autophagy (Greek for self-eating) has been increasing recognized being essential for cells to maintain homeostasis and also protect the organism against diverse pathogens and cancerous cells.

    Collapse Research 
    Collapse Research Activities and Funding
    Targeting the host NDP kinase to abrogate viral dissemination
    NIH/NIDCR R21DE028256Jan 4, 2019 - Dec 31, 2020
    Role: Principal Investigator
    Molecular Mechanism of UV Protection in Cutaneous Melanoma
    NIH/NIEHS R01ES029092Jan 1, 2019 - Dec 31, 2023
    Role: Principal Investigator
    A Novel Modulator of Notch in Acute Lymphoblastic Leukemia
    NIH/NCI R21CA161436Aug 1, 2011 - Jul 31, 2014
    Role: Principal Investigator
    Novel mechanism for UVRAG in genome stability and tumor suppression
    NIH/NCI R01CA140964Jul 1, 2009 - Dec 31, 2019
    Role: Principal Investigator
    Immune Evasion of Autophagy in Gamma-Herpesviruses infection
    NIH/NIAID R21AI083841Jun 15, 2009 - May 31, 2012
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Li S, Song Y, Quach C, Guo H, Jang GB, Maazi H, Zhao S, Sands NA, Liu Q, In GK, Peng D, Yuan W, Machida K, Yu M, Akbari O, Hagiya A, Yang Y, Punj V, Tang L, Liang C. Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance. Nat Commun. 2019 04 12; 10(1):1693. PMID: 30979895.
      View in: PubMed
    2. Shao Q, Liang C, Chang Q, Zhang W, Yang M, Chen JF. C9orf72 deficiency promotes motor deficits of a C9ALS/FTD mouse model in a dose-dependent manner. Acta Neuropathol Commun. 2019 Mar 04; 7(1):32. PMID: 30832726.
      View in: PubMed
    3. Li S, Jang GB, Quach C, Liang C. Darkening with UVRAG. Autophagy. 2018 Sep 13; 1-2. PMID: 30209981.
      View in: PubMed
    4. Yang Y, Jang GB, Yang X, Wang Q, He S, Li S, Quach C, Zhao S, Li F, Yuan Z, Lee HR, Zhong H, Liang C. Central role of autophagic UVRAG in melanogenesis and the suntan response. Proc Natl Acad Sci U S A. 2018 08 14; 115(33):E7728-E7737. PMID: 30061422.
      View in: PubMed
    5. Liang Q, Wei D, Chung B, Brulois KF, Guo C, Dong S, Gao SJ, Feng P, Liang C, Jung JU. Novel Role of vBcl2 in the Virion Assembly of Kaposi's Sarcoma-Associated Herpesvirus. J Virol. 2018 02 15; 92(4). PMID: 29167347.
      View in: PubMed
    6. Guo J, Jayaprakash P, Dan J, Wise P, Jang GB, Liang C, Chen M, Woodley DT, Fabbri M, Li W. PRAS40 Connects Microenvironmental Stress Signaling to Exosome-Mediated Secretion. Mol Cell Biol. 2017 Oct 01; 37(19). PMID: 28674187.
      View in: PubMed
    7. Yang Y, Quach C, Liang C. Autophagy modulator plays a part in UV protection. Autophagy. 2016 09; 12(9):1677-8. PMID: 27439570.
      View in: PubMed
    8. Yang Y, He S, Wang Q, Li F, Kwak MJ, Chen S, O'Connell D, Zhang T, Pirooz SD, Jeon Y, Chimge NO, Frenkel B, Choi Y, Aldrovandi GM, Oh BH, Yuan Z, Liang C. Autophagic UVRAG Promotes UV-Induced Photolesion Repair by Activation of the CRL4(DDB2) E3 Ligase. Mol Cell. 2016 05 19; 62(4):507-19. PMID: 27203177; PMCID: PMC4875571 [Available on 05/19/17].
    9. O'Connell D, Liang C. Autophagy interaction with herpes simplex virus type-1 infection. Autophagy. 2016; 12(3):451-9. PMID: 26934628; PMCID: PMC4836034 [Available on 03/02/17].
    10. Chimge NO, Little GH, Baniwal SK, Adisetiyo H, Xie Y, Zhang T, O'Laughlin A, Liu ZY, Ulrich P, Martin A, Mhawech-Fauceglia P, Ellis MJ, Tripathy D, Groshen S, Liang C, Li Z, Schones DE, Frenkel B. RUNX1 prevents oestrogen-mediated AXIN1 suppression and ß-catenin activation in ER-positive breast cancer. Nat Commun. 2016 Feb 26; 7:10751. PMID: 26916619; PMCID: PMC4773428.
    11. He S, Zhao Z, Yang Y, O'Connell D, Zhang X, Oh S, Ma B, Lee JH, Zhang T, Varghese B, Yip J, Dolatshahi Pirooz S, Li M, Zhang Y, Li GM, Ellen Martin S, Machida K, Liang C. Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers. Nat Commun. 2015 Aug 03; 6:7839. PMID: 26234763; PMCID: PMC4526116.
    12. Minassian A, Zhang J, He S, Zhao J, Zandi E, Saito T, Liang C, Feng P. An Internally Translated MAVS Variant Exposes Its Amino-terminal TRAF-Binding Motifs to Deregulate Interferon Induction. PLoS Pathog. 2015 Jul; 11(7):e1005060. PMID: 26221961; PMCID: PMC4519330.
    13. He S, Zhao J, Song S, He X, Minassian A, Zhou Y, Zhang J, Brulois K, Wang Y, Cabo J, Zandi E, Liang C, Jung JU, Zhang X, Feng P. Viral pseudo-enzymes activate RIG-I via deamidation to evade cytokine production. Mol Cell. 2015 Apr 02; 58(1):134-46. PMID: 25752576; PMCID: PMC4385502.
    14. Liang Q, Chang B, Lee P, Brulois KF, Ge J, Shi M, Rodgers MA, Feng P, Oh BH, Liang C, Jung JU. Identification of the Essential Role of Viral Bcl-2 for Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication. J Virol. 2015 May; 89(10):5308-17. PMID: 25740994; PMCID: PMC4442505.
    15. He S, Liang C. Frameshift mutation of UVRAG: Switching a tumor suppressor to an oncogene in colorectal cancer. Autophagy. 2015; 11(10):1939-40. PMID: 26327192; PMCID: PMC4824576.
    16. Yang Y, Liang C. MicroRNAs: an emerging player in autophagy. ScienceOpen Res. 2015; 2015. PMID: 26744638.
      View in: PubMed
    17. Liang C, Oh BH, Jung JU. Novel functions of viral anti-apoptotic factors. Nat Rev Microbiol. 2015 Jan; 13(1):7-12. PMID: 25363821; PMCID: PMC4420620.
    18. Pirooz S, He S, O'Connell D, Khalilzadeh P, Yang Y, Liang C. Viruses customize autophagy protein for efficient viral entry. Autophagy. 2014 Jul; 10(7):1355-6. PMID: 24905575; PMCID: PMC4203565.
    19. Pirooz SD, He S, Zhang T, Zhang X, Zhao Z, Oh S, O'Connell D, Khalilzadeh P, Amini-Bavil-Olyaee S, Farzan M, Liang C. UVRAG is required for virus entry through combinatorial interaction with the class C-Vps complex and SNAREs. Proc Natl Acad Sci U S A. 2014 Feb 18; 111(7):2716-21. PMID: 24550300; PMCID: PMC3932887.
    20. He S, O'Connell D, Zhang X, Yang Y, Liang C. The intersection of Golgi-ER retrograde and autophagic trafficking. Autophagy. 2014 Jan; 10(1):180-1. PMID: 24246972; PMCID: PMC4389875.
    21. He S, Ni D, Ma B, Lee JH, Zhang T, Ghozalli I, Pirooz SD, Zhao Z, Bharatham N, Li B, Oh S, Lee WH, Takahashi Y, Wang HG, Minassian A, Feng P, Deretic V, Pepperkok R, Tagaya M, Yoon HS, Liang C. PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex. Nat Cell Biol. 2013 Oct; 15(10):1206-1219. PMID: 24056303; PMCID: PMC3805255.
    22. Zhao Z, Ni D, Ghozalli I, Pirooz SD, Ma B, Liang C. UVRAG: at the crossroad of autophagy and genomic stability. Autophagy. 2012 Sep; 8(9):1392-3. PMID: 22885520; PMCID: PMC3442888.
    23. Kim HJ, Zhong Q, Sheng ZH, Yoshimori T, Liang C, Jung JU. Beclin-1-interacting autophagy protein Atg14L targets the SNARE-associated protein Snapin to coordinate endocytic trafficking. J Cell Sci. 2012 Oct 15; 125(Pt 20):4740-50. PMID: 22797916; PMCID: PMC4074282.
    24. Zhao Z, Oh S, Li D, Ni D, Pirooz SD, Lee JH, Yang S, Lee JY, Ghozalli I, Costanzo V, Stark JM, Liang C. A dual role for UVRAG in maintaining chromosomal stability independent of autophagy. Dev Cell. 2012 May 15; 22(5):1001-16. PMID: 22542840; PMCID: PMC3356442.
    25. Yang CS, Lee JS, Rodgers M, Min CK, Lee JY, Kim HJ, Lee KH, Kim CJ, Oh B, Zandi E, Yue Z, Kramnik I, Liang C, Jung JU. Autophagy protein Rubicon mediates phagocytic NADPH oxidase activation in response to microbial infection or TLR stimulation. Cell Host Microbe. 2012 Mar 15; 11(3):264-76. PMID: 22423966; PMCID: PMC3616771.
    26. Liang C. Viral FLIPping autophagy for longevity. Cell Host Microbe. 2012 Feb 16; 11(2):101-3. PMID: 22341458; PMCID: PMC4401464.
    27. Pirooz SD, Lee JH, Zhao Z, Ni D, Oh S, Liang C. Measurement of ?HV68 infection in mice. J Vis Exp. 2011 Nov 22; (57). PMID: 22127138; PMCID: PMC3308616.
    28. Oh S, Pirooz SD, Ni D, Zhao Z, Liang C. Anti-autophagic Bcl-2: Not just an innocent bystander. Autophagy. 2011 Feb; 7(2):231-2. PMID: 21099349; PMCID: PMC3679092.
    29. Oh S, E X, Hwang S, Liang C. Autophagy evasion in herpesviral latency. Autophagy. 2010 Jan; 6(1):151-2. PMID: 19923915; PMCID: PMC2847627.
    30. Liang C, Jung JU. Autophagy genes as tumor suppressors. Curr Opin Cell Biol. 2010 Apr; 22(2):226-33. PMID: 19945837; PMCID: PMC2854193.
    31. Lee JS, Li Q, Lee JY, Lee SH, Jeong JH, Lee HR, Chang H, Zhou FC, Gao SJ, Liang C, Jung JU. FLIP-mediated autophagy regulation in cell death control. Nat Cell Biol. 2009 Nov; 11(11):1355-62. PMID: 19838173; PMCID: PMC2802862.
    32. Lee HR, Kim MH, Lee JS, Liang C, Jung JU. Viral interferon regulatory factors. J Interferon Cytokine Res. 2009 Sep; 29(9):621-7. PMID: 19715458; PMCID: PMC2956608.
    33. Gack MU, Kirchhofer A, Shin YC, Inn KS, Liang C, Cui S, Myong S, Ha T, Hopfner KP, Jung JU. Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction. Proc Natl Acad Sci U S A. 2008 Oct 28; 105(43):16743-8. PMID: 18948594; PMCID: PMC2575490.
    34. Liang C, Lee JS, Jung JU. Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis. Semin Cancer Biol. 2008 Dec; 18(6):423-36. PMID: 18948197.
      View in: PubMed
    35. Sir D, Liang C, Chen WL, Jung JU, Ou JH. Perturbation of autophagic pathway by hepatitis C virus. Autophagy. 2008 Aug; 4(6):830-1. PMID: 18635950; PMCID: PMC2574555.
    36. Liang C, Sir D, Lee S, Ou JH, Jung JU. Beyond autophagy: the role of UVRAG in membrane trafficking. Autophagy. 2008 Aug; 4(6):817-20. PMID: 18612260; PMCID: PMC2878715.
    37. Liang C, Lee JS, Inn KS, Gack MU, Li Q, Roberts EA, Vergne I, Deretic V, Feng P, Akazawa C, Jung JU. Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking. Nat Cell Biol. 2008 Jul; 10(7):776-87. PMID: 18552835; PMCID: PMC2878716.