Chengyu Liang, MD, PhD
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Title(s) | Associate Professor of Molecular Microbiology & Immunology |
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Phone | +1 323 442 7840 |
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vCard | Download vCard |
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Overview Research in my lab is centered on understanding the basic principle of cellular processes including apoptosis and autophagy, cell cycle regulation and genomic stability, as well as intracellular trafficking matrix in the development of cancer and infectious disease. Being a lysosome-dependent quality control mechanism and house-cleaning activity of the cessll, autophagy (Greek for self-eating) has been increasing recognized being essential for cells to maintain homeostasis and also protect the organism against diverse pathogens and cancerous cells.
Research ORNG Applications Bibliographic
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Tang X, Chang C, Guo J, Lincoln V, Liang C, Chen M, Woodley DT, Li W. Tumour-Secreted Hsp90a on External Surface of Exosomes Mediates Tumour - Stromal Cell Communication via Autocrine and Paracrine Mechanisms. Sci Rep. 2019 Oct 22; 9(1):15108. PMID: 31641193.
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Liang C, Shao Q, Zhang W, Yang M, Chang Q, Chen R, Chen JF. Smcr8 deficiency disrupts axonal transport-dependent lysosomal function and promotes axonal swellings and gain of toxicity in C9ALS/FTD mouse models. Hum Mol Genet. 2019 Oct 18. PMID: 31625563.
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Li S, Song Y, Quach C, Nemecio D, Liang C. Revisiting the role of autophagy in melanoma. Autophagy. 2019 Oct; 15(10):1843-1844. PMID: 31242070.
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Li S, Song Y, Quach C, Guo H, Jang GB, Maazi H, Zhao S, Sands NA, Liu Q, In GK, Peng D, Yuan W, Machida K, Yu M, Akbari O, Hagiya A, Yang Y, Punj V, Tang L, Liang C. Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance. Nat Commun. 2019 04 12; 10(1):1693. PMID: 30979895.
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Shao Q, Liang C, Chang Q, Zhang W, Yang M, Chen JF. C9orf72 deficiency promotes motor deficits of a C9ALS/FTD mouse model in a dose-dependent manner. Acta Neuropathol Commun. 2019 Mar 04; 7(1):32. PMID: 30832726.
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Li S, Jang GB, Quach C, Liang C. Darkening with UVRAG. Autophagy. 2019 Feb; 15(2):366-367. PMID: 30209981.
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Yang Y, Jang GB, Yang X, Wang Q, He S, Li S, Quach C, Zhao S, Li F, Yuan Z, Lee HR, Zhong H, Liang C. Central role of autophagic UVRAG in melanogenesis and the suntan response. Proc Natl Acad Sci U S A. 2018 08 14; 115(33):E7728-E7737. PMID: 30061422.
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Liang Q, Wei D, Chung B, Brulois KF, Guo C, Dong S, Gao SJ, Feng P, Liang C, Jung JU. Novel Role of vBcl2 in the Virion Assembly of Kaposi's Sarcoma-Associated Herpesvirus. J Virol. 2018 02 15; 92(4). PMID: 29167347.
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Guo J, Jayaprakash P, Dan J, Wise P, Jang GB, Liang C, Chen M, Woodley DT, Fabbri M, Li W. PRAS40 Connects Microenvironmental Stress Signaling to Exosome-Mediated Secretion. Mol Cell Biol. 2017 Oct 01; 37(19). PMID: 28674187.
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Yang Y, Quach C, Liang C. Autophagy modulator plays a part in UV protection. Autophagy. 2016 09; 12(9):1677-8. PMID: 27439570.
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Yang Y, He S, Wang Q, Li F, Kwak MJ, Chen S, O'Connell D, Zhang T, Pirooz SD, Jeon YH, Chimge NO, Frenkel B, Choi Y, Aldrovandi GM, Oh BH, Yuan Z, Liang C. Autophagic UVRAG Promotes UV-Induced Photolesion Repair by Activation of the CRL4(DDB2) E3 Ligase. Mol Cell. 2016 05 19; 62(4):507-19. PMID: 27203177.
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O'Connell D, Liang C. Autophagy interaction with herpes simplex virus type-1 infection. Autophagy. 2016; 12(3):451-9. PMID: 26934628.
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Chimge NO, Little GH, Baniwal SK, Adisetiyo H, Xie Y, Zhang T, O'Laughlin A, Liu ZY, Ulrich P, Martin A, Mhawech-Fauceglia P, Ellis MJ, Tripathy D, Groshen S, Liang C, Li Z, Schones DE, Frenkel B. RUNX1 prevents oestrogen-mediated AXIN1 suppression and ß-catenin activation in ER-positive breast cancer. Nat Commun. 2016 Feb 26; 7:10751. PMID: 26916619.
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He S, Zhao Z, Yang Y, O'Connell D, Zhang X, Oh S, Ma B, Lee JH, Zhang T, Varghese B, Yip J, Dolatshahi Pirooz S, Li M, Zhang Y, Li GM, Ellen Martin S, Machida K, Liang C. Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers. Nat Commun. 2015 Aug 03; 6:7839. PMID: 26234763.
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Minassian A, Zhang J, He S, Zhao J, Zandi E, Saito T, Liang C, Feng P. An Internally Translated MAVS Variant Exposes Its Amino-terminal TRAF-Binding Motifs to Deregulate Interferon Induction. PLoS Pathog. 2015 Jul; 11(7):e1005060. PMID: 26221961.
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He S, Zhao J, Song S, He X, Minassian A, Zhou Y, Zhang J, Brulois K, Wang Y, Cabo J, Zandi E, Liang C, Jung JU, Zhang X, Feng P. Viral pseudo-enzymes activate RIG-I via deamidation to evade cytokine production. Mol Cell. 2015 Apr 02; 58(1):134-46. PMID: 25752576.
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Liang Q, Chang B, Lee P, Brulois KF, Ge J, Shi M, Rodgers MA, Feng P, Oh BH, Liang C, Jung JU. Identification of the Essential Role of Viral Bcl-2 for Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication. J Virol. 2015 May; 89(10):5308-17. PMID: 25740994.
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He S, Liang C. Frameshift mutation of UVRAG: Switching a tumor suppressor to an oncogene in colorectal cancer. Autophagy. 2015; 11(10):1939-40. PMID: 26327192.
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Yang Y, Liang C. MicroRNAs: an emerging player in autophagy. ScienceOpen Res. 2015; 2015. PMID: 26744638.
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Liang C, Oh BH, Jung JU. Novel functions of viral anti-apoptotic factors. Nat Rev Microbiol. 2015 Jan; 13(1):7-12. PMID: 25363821.
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Pirooz S, He S, O'Connell D, Khalilzadeh P, Yang Y, Liang C. Viruses customize autophagy protein for efficient viral entry. Autophagy. 2014 Jul; 10(7):1355-6. PMID: 24905575.
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Pirooz SD, He S, Zhang T, Zhang X, Zhao Z, Oh S, O'Connell D, Khalilzadeh P, Amini-Bavil-Olyaee S, Farzan M, Liang C. UVRAG is required for virus entry through combinatorial interaction with the class C-Vps complex and SNAREs. Proc Natl Acad Sci U S A. 2014 Feb 18; 111(7):2716-21. PMID: 24550300.
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He S, O'Connell D, Zhang X, Yang Y, Liang C. The intersection of Golgi-ER retrograde and autophagic trafficking. Autophagy. 2014 Jan; 10(1):180-1. PMID: 24246972.
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He S, Ni D, Ma B, Lee JH, Zhang T, Ghozalli I, Pirooz SD, Zhao Z, Bharatham N, Li B, Oh S, Lee WH, Takahashi Y, Wang HG, Minassian A, Feng P, Deretic V, Pepperkok R, Tagaya M, Yoon HS, Liang C. PtdIns(3)P-bound UVRAG coordinates Golgi-ER retrograde and Atg9 transport by differential interactions with the ER tether and the beclin 1 complex. Nat Cell Biol. 2013 Oct; 15(10):1206-1219. PMID: 24056303.
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Zhao Z, Ni D, Ghozalli I, Pirooz SD, Ma B, Liang C. UVRAG: at the crossroad of autophagy and genomic stability. Autophagy. 2012 Sep; 8(9):1392-3. PMID: 22885520.
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Kim HJ, Zhong Q, Sheng ZH, Yoshimori T, Liang C, Jung JU. Beclin-1-interacting autophagy protein Atg14L targets the SNARE-associated protein Snapin to coordinate endocytic trafficking. J Cell Sci. 2012 Oct 15; 125(Pt 20):4740-50. PMID: 22797916.
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Zhao Z, Oh S, Li D, Ni D, Pirooz SD, Lee JH, Yang S, Lee JY, Ghozalli I, Costanzo V, Stark JM, Liang C. A dual role for UVRAG in maintaining chromosomal stability independent of autophagy. Dev Cell. 2012 May 15; 22(5):1001-16. PMID: 22542840.
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Yang CS, Lee JS, Rodgers M, Min CK, Lee JY, Kim HJ, Lee KH, Kim CJ, Oh B, Zandi E, Yue Z, Kramnik I, Liang C, Jung JU. Autophagy protein Rubicon mediates phagocytic NADPH oxidase activation in response to microbial infection or TLR stimulation. Cell Host Microbe. 2012 Mar 15; 11(3):264-76. PMID: 22423966.
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Liang C. Viral FLIPping autophagy for longevity. Cell Host Microbe. 2012 Feb 16; 11(2):101-3. PMID: 22341458.
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Pirooz SD, Lee JH, Zhao Z, Ni D, Oh S, Liang C. Measurement of ?HV68 infection in mice. J Vis Exp. 2011 Nov 22; (57). PMID: 22127138.
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Oh S, Pirooz SD, Ni D, Zhao Z, Liang C. Anti-autophagic Bcl-2: Not just an innocent bystander. Autophagy. 2011 Feb; 7(2):231-2. PMID: 21099349.
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Oh S, E X, Hwang S, Liang C. Autophagy evasion in herpesviral latency. Autophagy. 2010 Jan; 6(1):151-2. PMID: 19923915.
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Liang C, Jung JU. Autophagy genes as tumor suppressors. Curr Opin Cell Biol. 2010 Apr; 22(2):226-33. PMID: 19945837.
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Lee JS, Li Q, Lee JY, Lee SH, Jeong JH, Lee HR, Chang H, Zhou FC, Gao SJ, Liang C, Jung JU. FLIP-mediated autophagy regulation in cell death control. Nat Cell Biol. 2009 Nov; 11(11):1355-62. PMID: 19838173.
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Lee HR, Kim MH, Lee JS, Liang C, Jung JU. Viral interferon regulatory factors. J Interferon Cytokine Res. 2009 Sep; 29(9):621-7. PMID: 19715458.
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Gack MU, Kirchhofer A, Shin YC, Inn KS, Liang C, Cui S, Myong S, Ha T, Hopfner KP, Jung JU. Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction. Proc Natl Acad Sci U S A. 2008 Oct 28; 105(43):16743-8. PMID: 18948594.
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Liang C, Lee JS, Jung JU. Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis. Semin Cancer Biol. 2008 Dec; 18(6):423-36. PMID: 18948197.
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Sir D, Liang C, Chen WL, Jung JU, Ou JH. Perturbation of autophagic pathway by hepatitis C virus. Autophagy. 2008 Aug; 4(6):830-1. PMID: 18635950.
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Liang C, Sir D, Lee S, Ou JH, Jung JU. Beyond autophagy: the role of UVRAG in membrane trafficking. Autophagy. 2008 Aug; 4(6):817-20. PMID: 18612260.
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Liang C, Lee JS, Inn KS, Gack MU, Li Q, Roberts EA, Vergne I, Deretic V, Feng P, Akazawa C, Jung JU. Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking. Nat Cell Biol. 2008 Jul; 10(7):776-87. PMID: 18552835.
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