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Burcu Darst

Title(s)Postdoctoral Scholar - Research Associate
Address1450 Biggy Street
Health Sciences Campus
Los Angeles CA 90033
ORCID ORCID Icon0000-0002-6205-4632 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of Wisconsin, MadisonPhD2018Genetic Epidemiology
    University of California, San DiegoBS2009Cognitive Neuroscience
    Collapse Awards and Honors
    American Association for Cancer Research2021NextGen Star
    Center for Public Health Genomics, University of Virginia2020Emerging Scholar in Genome Sciences
    American Association for Cancer Research2020AACR Scholar-in-Training Award
    American Association for Cancer Research2020AACR-Doreen J. Putrah Cancer Research Foundation Scholar-in-Training Award
    American Society of Human Genetics2019Reviewer’s Choice Abstract
    American Association for Cancer Research2019AACR Scholar-in-Training Award
    University of Colorado Anschutz2019Chan-Zuckerberg Initiative Travel Award
    Informatics Training Conference, National Library of Medicine2018Best Talk
    Alzheimer’s Association International Conference2018Travel Fellowship
    International Genetic Epidemiology Society2017Ludmer Center Award
    University of Wisconsin, Madison2017Donn D’Alessio Student Award
    Alzheimer’s Association International Conference2017Travel Fellowship
    University of Wisconsin, Madison2017Student Research Grants Competition Conference Presentation Funds
    University of Wisconsin, Madison2015  - 2018Computation and Informatics in Biology and Medicine Pre-Doctoral Trainee, NIH 5T15LM007359
    Genetic Analysis Workshop 192014Student Travel Award
    University of Wisconsin, Madison2014Rankin/Skatrud Travel Stipend Award
    Rockefeller University2014Rockefeller Advanced Gene Mapping Course Travel Fellowship

    Collapse Research 
    Collapse Research Activities and Funding
    Integrating Genomics and Metabolomics to Develop Predictive Models of Prostate Cancer in Multiethnic Men
    NIH K99CA246063Feb 1, 2020 - Jan 31, 2022
    Role: Principal Investigator
    ARCS Foundation Development Award Oct 1, 2018 - Oct 1, 2021
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Publisher Correction: Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction. Nat Genet. 2021 Jan 20. Conti DV, Darst BF, Moss LC, Saunders EJ, Sheng X, Chou A, Schumacher FR, Olama AAA, Benlloch S, Dadaev T, Brook MN, Sahimi A, Hoffmann TJ, Takahashi A, Matsuda K, Momozawa Y, Fujita M, Muir K, Lophatananon A, Wan P, Le Marchand L, Wilkens LR, Stevens VL, Gapstur SM, Carter BD, Schleutker J, Tammela TLJ, Sipeky C, Auvinen A, Giles GG, Southey MC, MacInnis RJ, Cybulski C, Wokolorczyk D, Lubinski J, Neal DE, Donovan JL, Hamdy FC, Martin RM, Nordestgaard BG, Nielsen SF, Weischer M, Bojesen SE, Røder MA, Iversen P, Batra J, Chambers S, Moya L, Horvath L, Clements JA, Tilley W, Risbridger GP, Gronberg H, Aly M, Szulkin R, Eklund M, Nordström T, Pashayan N, Dunning AM, Ghoussaini M, Travis RC, Key TJ, Riboli E, Park JY, Sellers TA, Lin HY, Albanes D, Weinstein SJ, Mucci LA, Giovannucci E, Lindstrom S, Kraft P, Hunter DJ, Penney KL, Turman C, Tangen CM, Goodman PJ, Thompson IM, Hamilton RJ, Fleshner NE, Finelli A, Parent MÉ, Stanford JL, Ostrander EA, Geybels MS, Koutros S, Freeman LEB, Stampfer M, Wolk A, Håkansson N, Andriole GL, Hoover RN, Machiela MJ, Sørensen KD, Borre M, Blot WJ, Zheng W, Yeboah ED, Mensah JE, Lu YJ, Zhang HW, Feng N, Mao X, Wu Y, Zhao SC, Sun Z, Thibodeau SN, McDonnell SK, Schaid DJ, West CML, Burnet N, Barnett G, Maier C, Schnoeller T, Luedeke M, Kibel AS, Drake BF, Cussenot O, Cancel-Tassin G, Menegaux F, Truong T, Koudou YA, John EM, Grindedal EM, Maehle L, Khaw KT, Ingles SA, Stern MC, Vega A, Gómez-Caamaño A, Fachal L, Rosenstein BS, Kerns SL, Ostrer H, Teixeira MR, Paulo P, Brandão A, Watya S, Lubwama A, Bensen JT, Fontham ETH, Mohler J, Taylor JA, Kogevinas M, Llorca J, Castaño-Vinyals G, Cannon-Albright L, Teerlink CC, Huff CD, Strom SS, Multigner L, Blanchet P, Brureau L, Kaneva R, Slavov C, Mitev V, Leach RJ, Weaver B, Brenner H, Cuk K, Holleczek B, Saum KU, Klein EA, Hsing AW, Kittles RA, Murphy AB, Logothetis CJ, Kim J, Neuhausen SL, Steele L, Ding YC, Isaacs WB, Nemesure B, Hennis AJM, Carpten J, Pandha H, Michael A, De Ruyck K, De Meerleer G, Ost P, Xu J, Razack A, Lim J, Teo SH, Newcomb LF, Lin DW, Fowke JH, Neslund-Dudas C, Rybicki BA, Gamulin M, Lessel D, Kulis T, Usmani N, Singhal S, Parliament M, Claessens F, Joniau S, Van den Broeck T, Gago-Dominguez M, Castelao JE, Martinez ME, Larkin S, Townsend PA, Aukim-Hastie C, Bush WS, Aldrich MC, Crawford DC, Srivastava S, Cullen JC, Petrovics G, Casey G, Roobol MJ, Jenster G, van Schaik RHN, Hu JJ, Sanderson M, Varma R, McKean-Cowdin R, Torres M, Mancuso N, Berndt SI, Van Den Eeden SK, Easton DF, Chanock SJ, Cook MB, Wiklund F, Nakagawa H, Witte JS, Eeles RA, Kote-Jarai Z, Haiman CA. PMID: 33473200.
      View in: PubMed   Mentions:    Fields:    
    2. Cerebrospinal fluid metabolomics identifies 19 brain-related phenotype associations. Commun Biol. 2021 Jan 12; 4(1):63. Panyard DJ, Kim KM, Darst BF, Deming YK, Zhong X, Wu Y, Kang H, Carlsson CM, Johnson SC, Asthana S, Engelman CD, Lu Q. PMID: 33437055.
      View in: PubMed   Mentions:
    3. Metabolites Associated with Early Cognitive Changes Implicated in Alzheimer's Disease. J Alzheimers Dis. 2021 Jan 08. Darst BF, Huo Z, Jonaitis EM, Koscik RL, Clark LR, Lu Q, Kremen WS, Franz CE, Rana B, Lyons MJ, Hogan KJ, Zhao J, Johnson SC, Engelman CD. PMID: 33427733.
      View in: PubMed   Mentions:    Fields:    
    4. Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction. Nat Genet. 2021 Jan; 53(1):65-75. Conti DV, Darst BF, Moss LC, Saunders EJ, Sheng X, Chou A, Schumacher FR, Olama AAA, Benlloch S, Dadaev T, Brook MN, Sahimi A, Hoffmann TJ, Takahashi A, Matsuda K, Momozawa Y, Fujita M, Muir K, Lophatananon A, Wan P, Le Marchand L, Wilkens LR, Stevens VL, Gapstur SM, Carter BD, Schleutker J, Tammela TLJ, Sipeky C, Auvinen A, Giles GG, Southey MC, MacInnis RJ, Cybulski C, Wokolorczyk D, Lubinski J, Neal DE, Donovan JL, Hamdy FC, Martin RM, Nordestgaard BG, Nielsen SF, Weischer M, Bojesen SE, Røder MA, Iversen P, Batra J, Chambers S, Moya L, Horvath L, Clements JA, Tilley W, Risbridger GP, Gronberg H, Aly M, Szulkin R, Eklund M, Nordström T, Pashayan N, Dunning AM, Ghoussaini M, Travis RC, Key TJ, Riboli E, Park JY, Sellers TA, Lin HY, Albanes D, Weinstein SJ, Mucci LA, Giovannucci E, Lindstrom S, Kraft P, Hunter DJ, Penney KL, Turman C, Tangen CM, Goodman PJ, Thompson IM, Hamilton RJ, Fleshner NE, Finelli A, Parent MÉ, Stanford JL, Ostrander EA, Geybels MS, Koutros S, Freeman LEB, Stampfer M, Wolk A, Håkansson N, Andriole GL, Hoover RN, Machiela MJ, Sørensen KD, Borre M, Blot WJ, Zheng W, Yeboah ED, Mensah JE, Lu YJ, Zhang HW, Feng N, Mao X, Wu Y, Zhao SC, Sun Z, Thibodeau SN, McDonnell SK, Schaid DJ, West CML, Burnet N, Barnett G, Maier C, Schnoeller T, Luedeke M, Kibel AS, Drake BF, Cussenot O, Cancel-Tassin G, Menegaux F, Truong T, Koudou YA, John EM, Grindedal EM, Maehle L, Khaw KT, Ingles SA, Stern MC, Vega A, Gómez-Caamaño A, Fachal L, Rosenstein BS, Kerns SL, Ostrer H, Teixeira MR, Paulo P, Brandão A, Watya S, Lubwama A, Bensen JT, Fontham ETH, Mohler J, Taylor JA, Kogevinas M, Llorca J, Castaño-Vinyals G, Cannon-Albright L, Teerlink CC, Huff CD, Strom SS, Multigner L, Blanchet P, Brureau L, Kaneva R, Slavov C, Mitev V, Leach RJ, Weaver B, Brenner H, Cuk K, Holleczek B, Saum KU, Klein EA, Hsing AW, Kittles RA, Murphy AB, Logothetis CJ, Kim J, Neuhausen SL, Steele L, Ding YC, Isaacs WB, Nemesure B, Hennis AJM, Carpten J, Pandha H, Michael A, De Ruyck K, De Meerleer G, Ost P, Xu J, Razack A, Lim J, Teo SH, Newcomb LF, Lin DW, Fowke JH, Neslund-Dudas C, Rybicki BA, Gamulin M, Lessel D, Kulis T, Usmani N, Singhal S, Parliament M, Claessens F, Joniau S, Van den Broeck T, Gago-Dominguez M, Castelao JE, Martinez ME, Larkin S, Townsend PA, Aukim-Hastie C, Bush WS, Aldrich MC, Crawford DC, Srivastava S, Cullen JC, Petrovics G, Casey G, Roobol MJ, Jenster G, van Schaik RHN, Hu JJ, Sanderson M, Varma R, McKean-Cowdin R, Torres M, Mancuso N, Berndt SI, Van Den Eeden SK, Easton DF, Chanock SJ, Cook MB, Wiklund F, Nakagawa H, Witte JS, Eeles RA, Kote-Jarai Z, Haiman CA. PMID: 33398198.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Findings from a Genetic Sequencing Investigation of Men with Familial and Aggressive Prostate Cancer. Eur Urol. 2021 Mar; 79(3):362-363. PMID: 32994065.
      View in: PubMed   Mentions:    Fields:    
    6. Germline sequencing DNA repair genes in 5,545 men with aggressive and non-aggressive prostate cancer. J Natl Cancer Inst. 2020 Aug 27. Darst BF, Dadaev T, Saunders E, Sheng X, Wan P, Pooler L, Xia LY, Chanock S, Berndt SI, Gapstur SM, Stevens V, Albanes D, Weinstein SJ, Gnanapragasam V, Giles GG, Nguyen-Dumont T, Milne RL, Pomerantz M, Schmidt JA, Mucci L, Catalona WJ, Hetrick KN, Doheny KF, MacInnis RJ, Southey MC, Eeles RA, Wiklund F, Kote-Jarai Z, Conti DV, Haiman CA. PMID: 32853339.
      View in: PubMed   Mentions: 1     Fields:    
    7. A Germline Variant at 8q24 Contributes to Familial Clustering of Prostate Cancer in Men of African Ancestry. Eur Urol. 2020 09; 78(3):316-320. Darst BF, Wan P, Sheng X, Bensen JT, Ingles SA, Rybicki BA, Nemesure B, John EM, Fowke JH, Stevens VL, Berndt SI, Huff CD, Strom SS, Park JY, Zheng W, Ostrander EA, Walsh PC, Srivastava S, Carpten J, Sellers TA, Yamoah K, Murphy AB, Sanderson M, Crawford DC, Gapstur SM, Bush WS, Aldrich MC, Cussenot O, Yeager M, Petrovics G, Cullen J, Neslund-Dudas C, Kittles RA, Xu J, Stern MC, Kote-Jarai Z, Govindasami K, Chokkalingam AP, Multigner L, Parent ME, Menegaux F, Cancel-Tassin G, Kibel AS, Klein EA, Goodman PJ, Drake BF, Hu JJ, Clark PE, Blanchet P, Casey G, Hennis AJM, Lubwama A, Thompson IM, Leach R, Gundell SM, Pooler L, Xia L, Mohler JL, Fontham ETH, Smith GJ, Taylor JA, Eeles RA, Brureau L, Chanock SJ, Watya S, Stanford JL, Mandal D, Isaacs WB, Cooney K, Blot WJ, Conti DV, Haiman CA. PMID: 32409115.
      View in: PubMed   Mentions: 1     Fields:    
    8. The Four-Kallikrein Panel Is Effective in Identifying Aggressive Prostate Cancer in a Multiethnic Population. Cancer Epidemiol Biomarkers Prev. 2020 Jul; 29(7):1381-1388. Darst BF, Chou A, Wan P, Pooler L, Sheng X, Vertosick EA, Conti DV, Wilkens LR, Le Marchand L, Vickers AJ, Lilja HG, Haiman CA. PMID: 32385116.
      View in: PubMed   Mentions: 1     Fields:    
    9. Integrated analysis of genomics, longitudinal metabolomics, and Alzheimer's risk factors among 1,111 cohort participants. Genet Epidemiol. 2019 09; 43(6):657-674. Darst BF, Lu Q, Johnson SC, Engelman CD. PMID: 31104335.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    10. KLOTHO heterozygosity attenuates APOE4-related amyloid burden in preclinical AD. Neurology. 2019 Apr 16; 92(16):e1878-e1889. Erickson CM, Schultz SA, Oh JM, Darst BF, Ma Y, Norton D, Betthauser T, Gallagher CL, Carlsson CM, Bendlin BB, Asthana S, Hermann BP, Sager MA, Blennow K, Zetterberg H, Engelman CD, Christian BT, Johnson SC, Dubal DB, Okonkwo OC. PMID: 30867273.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    11. Carrier frequency estimation of Zellweger spectrum disorder using ExAC database and bioinformatics tools. Genet Med. 2019 09; 21(9):1969-1976. Vasiljevic E, Ye Z, Pavelec DM, Darst BF, Engelman CD, Baker MW. PMID: 30846882.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    12. Longitudinal plasma metabolomics of aging and sex. Aging (Albany NY). 2019 02 24; 11(4):1262-1282. Darst BF, Koscik RL, Hogan KJ, Johnson SC, Engelman CD. PMID: 30799310.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    13. The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer's disease. Alzheimers Res Ther. 2018 12 22; 10(1):124. Vogt NM, Romano KA, Darst BF, Engelman CD, Johnson SC, Carlsson CM, Asthana S, Blennow K, Zetterberg H, Bendlin BB, Rey FE. PMID: 30579367.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    14. Using recursive feature elimination in random forest to account for correlated variables in high dimensional data. BMC Genet. 2018 09 17; 19(Suppl 1):65. Darst BF, Malecki KC, Engelman CD. PMID: 30255764.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    15. Data mining and machine learning approaches for the integration of genome-wide association and methylation data: methodology and main conclusions from GAW20. BMC Genet. 2018 09 17; 19(Suppl 1):76. Darst B, Engelman CD, Tian Y, Lorenzo Bermejo J. PMID: 30255774.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    16. The effect of rare variants in TREM2 and PLD3 on longitudinal cognitive function in the Wisconsin Registry for Alzheimer's Prevention. Neurobiol Aging. 2018 06; 66:177.e1-177.e5. Engelman CD, Darst BF, Bilgel M, Vasiljevic E, Koscik RL, Jedynak BM, Johnson SC. PMID: 29395285.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    17. BDNF Val66Met predicts cognitive decline in the Wisconsin Registry for Alzheimer's Prevention. Neurology. 2017 May 30; 88(22):2098-2106. PMID: 28468845.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    18. Cardiorespiratory fitness alters the influence of a polygenic risk score on biomarkers of AD. Neurology. 2017 Apr 25; 88(17):1650-1658. PMID: 28341646.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    19. Macrovascular and microvascular cerebral blood flow in adults at risk for Alzheimer's disease. Alzheimers Dement (Amst). 2017; 7:48-55. PMID: 28239641.
      View in: PubMed   Mentions:
    20. Pathway-Specific Polygenic Risk Scores as Predictors of Amyloid-ß Deposition and Cognitive Function in a Sample at Increased Risk for Alzheimer's Disease. J Alzheimers Dis. 2017; 55(2):473-484. PMID: 27662287.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    21. Patient perspectives on whole-genome sequencing for undiagnosed diseases. Per Med. 2017 01; 14(1):17-25. Boeldt DL, Cheung C, Ariniello L, Darst BF, Topol S, Schork NJ, Philis-Tsimikas A, Torkamani A, Fortmann AL, Bloss CS. PMID: 29749824.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    22. Transmission and decorrelation methods for detecting rare variants using sequencing data from related individuals. BMC Proc. 2016; 10(Suppl 7):203-207. PMID: 27980637.
      View in: PubMed   Mentions:
    23. Prioritization of family member sequencing for the detection of rare variants. BMC Proc. 2016; 10(Suppl 7):227-231. PMID: 27980641.
      View in: PubMed   Mentions:
    24. Dyslexia and language impairment associated genetic markers influence cortical thickness and white matter in typically developing children. Brain Imaging Behav. 2016 Mar; 10(1):272-82. PMID: 25953057.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    25. A genome sequencing program for novel undiagnosed diseases. Genet Med. 2015 Dec; 17(12):995-1001. PMID: 25790160.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    26. Heritability of cognitive traits among siblings with a parental history of Alzheimer's disease. J Alzheimers Dis. 2015; 45(4):1149-55. PMID: 25649654.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    27. Candidate SNP associations of optimism and resilience in older adults: exploratory study of 935 community-dwelling adults. Am J Geriatr Psychiatry. 2014 Oct; 22(10):997-1006.e5. PMID: 24791650.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    28. Genome-wide association study of shared components of reading disability and language impairment. Genes Brain Behav. 2013 Nov; 12(8):792-801. PMID: 24024963.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    29. Evidence for the role of EPHX2 gene variants in anorexia nervosa. Mol Psychiatry. 2014 Jun; 19(6):724-32. PMID: 23999524.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    30. Perceptions of genetic counseling services in direct-to-consumer personal genomic testing. Clin Genet. 2013 Oct; 84(4):335-9. PMID: 23590221.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    31. Impact of direct-to-consumer genomic testing at long term follow-up. J Med Genet. 2013 Jun; 50(6):393-400. PMID: 23559530.
      View in: PubMed   Mentions: 53     Fields:    Translation:Humans
    32. Characteristics of genomic test consumers who spontaneously share results with their health care provider. Health Commun. 2014; 29(1):105-8. PMID: 23384116.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    33. Long-term influence of normal variation in neonatal characteristics on human brain development. Proc Natl Acad Sci U S A. 2012 Dec 04; 109(49):20089-94. PMID: 23169628.
      View in: PubMed   Mentions: 56     Fields:    Translation:Humans
    34. Multimodal imaging of the self-regulating developing brain. Proc Natl Acad Sci U S A. 2012 Nov 27; 109(48):19620-5. PMID: 23150548.
      View in: PubMed   Mentions: 75     Fields:    Translation:Humans
    35. Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans. Proc Natl Acad Sci U S A. 2012 Mar 06; 109(10):3985-90. PMID: 22343285.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    36. Direct-to-consumer personalized genomic testing. Hum Mol Genet. 2011 Oct 15; 20(R2):R132-41. PMID: 21828075.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
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