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Betty M. Chan, PharmD

TitleAssistant Professor of Clinical Pharmacy
InstitutionUniversity of Southern California
DepartmentPharmacology and Pharmaceutical Sciences
AddressNOR 2407
Health Sciences Campus
Los Angeles CA 90089-9171
Phone+1 323 865 3613
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    Dr. Chan received her Doctor of Pharmacy degree from USC School of Pharmacy in 1993. She then completed a residency in Clinical Practice at Cedars-Sinai Medical Center in 1994. Dr. Chan then went on and completed a specialty residency in Hematology-Oncology at the University of California, San Francisco in 1995. Since then, Dr. Chan has worked as a Clinical Pharmacist in the Hematology-Oncology/Bone Marrow & Stem Cell Transplantation Unit at Cedars-Sinai Medical Center and as a Clinical Pharmacist at the UCLA/Jonnson Comprehensive Cancer Center before joining the faculty of the USC School of Pharmacy in May 2001.


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Corcoran G, Chan B, Chiew A. Use and knowledge of single dose activated charcoal: A survey of Australian doctors. Emerg Med Australas. 2016 Oct; 28(5):578-85. PMID: 27555040.
      View in: PubMed
    2. Pan WJ, Hsu H, Rees WA, Lear SP, Lee F, Foltz IN, Rathanaswami P, Manchulenko K, Chan B, Zhang M, Xia XZ, Patel SK, Prince PJ, Doherty DR, Sheckler CM, Reynhardt KO, Krill CD, Harder BJ, Wisler JA, Brandvig JL, Lynch JL, Anderson AA, Wienkers LC, Borie DC. Pharmacology of AMG 181, a human anti-a4 ß7 antibody that specifically alters trafficking of gut-homing T cells. Br J Pharmacol. 2013 May; 169(1):51-68. PMID: 23425116; PMCID: PMC3632238.
    3. Falk GL, Chan B, Falk SE. Primary repair of giant hiatus hernia is satisfactory without mesh: early results of a method revisited. J Laparoendosc Adv Surg Tech A. 2012 Oct; 22(8):748-52. PMID: 22924459.
      View in: PubMed
    4. Chan B, Ho CS. The cognitive profile of Chinese children with mathematics difficulties. J Exp Child Psychol. 2010 Nov; 107(3):260-79. PMID: 20580379.
      View in: PubMed
    5. Cullen JF, Chan B, Wong CF, Chew WC. Giant cell (temporal) arteritis in Singapore: an occult case and the rationale of treatment. Singapore Med J. 2010 Jan; 51(1):73-7. PMID: 20200780.
      View in: PubMed
    6. Nicolò C, Sali M, Di Sante G, Geloso MC, Signori E, Penitente R, Uniyal S, Rinaldi M, Ingrosso L, Fazio VM, Chan B, Delogu G, Ria F. Mycobacterium smegmatis expressing a chimeric protein MPT64-proteolipid protein (PLP) 139-151 reorganizes the PLP-specific T cell repertoire favoring a CD8-mediated response and induces a relapsing experimental autoimmune encephalomyelitis. J Immunol. 2010 Jan 01; 184(1):222-35. PMID: 19949067.
      View in: PubMed
    7. Hui AY, Meens JA, Schick C, Organ SL, Qiao H, Tremblay EA, Schaeffer E, Uniyal S, Chan B, Elliott BE. Src and FAK mediate cell-matrix adhesion-dependent activation of Met during transformation of breast epithelial cells. J Cell Biochem. 2009 Aug 15; 107(6):1168-81. PMID: 19533669.
      View in: PubMed
    8. McKillop WM, Barrett JW, Pasternak SH, Chan B, Dekaban GA. The extracellular domain of CD11d regulates its cell surface expression. J Leukoc Biol. 2009 Oct; 86(4):851-62. PMID: 19571252.
      View in: PubMed
    9. Watson A, Morris VL, Chan B. Coordinated integrin and growth factor regulation of primary keratinocyte migration mediated through extracellular signal regulated kinase and phosphoinositide 3-kinase. Arch Dermatol Res. 2009 Apr; 301(4):307-17. PMID: 19330341.
      View in: PubMed
    10. Frontini MJ, O'Neil C, Sawyez C, Chan B, Huff MW, Pickering JG. Lipid incorporation inhibits Src-dependent assembly of fibronectin and type I collagen by vascular smooth muscle cells. Circ Res. 2009 Apr 10; 104(7):832-41. PMID: 19229059.
      View in: PubMed
    11. Ha SD, Martins A, Khazaie K, Han J, Chan B, Kim SO. Cathepsin B is involved in the trafficking of TNF-alpha-containing vesicles to the plasma membrane in macrophages. J Immunol. 2008 Jul 01; 181(1):690-7. PMID: 18566436.
      View in: PubMed
    12. Morris VL, Chan B. Interaction of epidermal growth factor, Ca2+, and matrix metalloproteinase-9 in primary keratinocyte migration. Wound Repair Regen. 2007 Nov-Dec; 15(6):907-15. PMID: 18028140.
      View in: PubMed
    13. Leung HC, Chin FY, Chan B. Discovering motifs with transcription factor domain knowledge. Pac Symp Biocomput. 2007; 472-83. PMID: 17990511.
      View in: PubMed
    14. Khan ZA, Farhangkhoee H, Mahon JL, Bere L, Gonder JR, Chan B, Uniyal S, Chakrabarti S. Endothelins: regulators of extracellular matrix protein production in diabetes. Exp Biol Med (Maywood). 2006 Jun; 231(6):1022-9. PMID: 16741042.
      View in: PubMed
    15. Nicolò C, Di Sante G, Orsini M, Rolla S, Columba-Cabezas S, Romano Spica V, Ricciardi G, Chan B, Ria F. Mycobacterium tuberculosis in the adjuvant modulates the balance of Th immune response to self-antigen of the CNS without influencing a "core" repertoire of specific T cells. Int Immunol. 2006 Feb; 18(2):363-74. PMID: 16415105.
      View in: PubMed
    16. Khan ZA, Chan B, Uniyal S, Barbin YP, Farhangkhoee H, Chen S, Chakrabarti S. EDB fibronectin and angiogenesis -- a novel mechanistic pathway. Angiogenesis. 2005; 8(3):183-96. PMID: 16308732.
      View in: PubMed
    17. Khan ZA, Caurtero J, Barbin YP, Chan B, Uniyal S, Chakrabarti S. ED-B fibronectin in non-small cell lung carcinoma. Exp Lung Res. 2005 Sep; 31(7):701-11. PMID: 16203624.
      View in: PubMed
    18. Chan B, Greenan G, McKeon F, Ellenberger T. Identification of a peptide fragment of DSCR1 that competitively inhibits calcineurin activity in vitro and in vivo. Proc Natl Acad Sci U S A. 2005 Sep 13; 102(37):13075-80. PMID: 16131541; PMCID: PMC1201586.
    19. Hutter JL, Chen J, Wan WK, Uniyal S, Leabu M, Chan B. Atomic force microscopy investigation of the dependence of cellular elastic moduli on glutaraldehyde fixation. J Microsc. 2005 Aug; 219(Pt 2):61-8. PMID: 16159341.
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    20. Ho WC, Uniyal S, Zhou H, Morris VL, Chan B. Threshold levels of ERK activation for chemotactic migration differ for NGF and EGF in rat pheochromocytoma PC12 cells. Mol Cell Biochem. 2005 Mar; 271(1-2):29-41. PMID: 15881653.
      View in: PubMed
    21. Leabu M, Uniyal S, Xie J, Xu YQ, Vladau C, Morris VL, Chan B. Integrin alpha2beta1 modulates EGF stimulation of Rho GTPase-dependent morphological changes in adherent human rhabdomyosarcoma RD cells. J Cell Physiol. 2005 Mar; 202(3):754-66. PMID: 15481063.
      View in: PubMed
    22. Miura K, Uniyal S, Leabu M, Oravecz T, Chakrabarti S, Morris VL, Chan B. Chemokine receptor CXCR4-beta1 integrin axis mediates tumorigenesis of osteosarcoma HOS cells. Biochem Cell Biol. 2005 Feb; 83(1):36-48. PMID: 15746965.
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    23. Knowlton MN, Chan B, Kelly GM. The zebrafish band 4.1 member Mir is involved in cell movements associated with gastrulation. Dev Biol. 2003 Dec 15; 264(2):407-29. PMID: 14651927.
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    24. Boyd ND, Chan B, Petersen NO. Beta1 integrins are distributed in adhesion structures with fibronectin and caveolin and in coated pits. Biochem Cell Biol. 2003 Oct; 81(5):335-48. PMID: 14569297.
      View in: PubMed
    25. Li S, Van Den Diepstraten C, D'Souza SJ, Chan B, Pickering JG. Vascular smooth muscle cells orchestrate the assembly of type I collagen via alpha2beta1 integrin, RhoA, and fibronectin polymerization. Am J Pathol. 2003 Sep; 163(3):1045-56. PMID: 12937145; PMCID: PMC1868248.
    26. Leabu M, Hinescu ME, Uniyal S, Chan B. Cell death in cell culture frame by frame. J Cell Mol Med. 2003 Apr-Jun; 7(2):192-3. PMID: 12927059.
      View in: PubMed
    27. Chan B, Lanyi A, Song HK, Griesbach J, Simarro-Grande M, Poy F, Howie D, Sumegi J, Terhorst C, Eck MJ. SAP couples Fyn to SLAM immune receptors. Nat Cell Biol. 2003 Feb; 5(2):155-60. PMID: 12545174.
      View in: PubMed
    28. Boyd ND, Chan B, Petersen NO. Adaptor protein-2 exhibits alpha 1 beta 1 or alpha 6 beta 1 integrin-dependent redistribution in rhabdomyosarcoma cells. Biochemistry. 2002 Jun 11; 41(23):7232-40. PMID: 12044154.
      View in: PubMed
    29. Chan B, Morris VL, Hangan-Steinman D, Jarvie B, Cialacu M, Laansoo J, Hunter G, Wan W, Uniyal S. Integrin alpha2beta1 on rat myeloma cells modulates interaction of alpha4beta1 integrin with vascular cell adhesion molecule-1 but not fibronectin. J Biomater Sci Polym Ed. 2002; 13(4):429-46. PMID: 12160302.
      View in: PubMed
    30. St Louis J, Uniyal S, Xu L, Chan E, Singh B, Chan B, Strejan GH. Tolerance induction by acylated peptides: suppression of EAE in the mouse with palmitoylated PLP peptides. J Neuroimmunol. 2001 Apr 02; 115(1-2):79-90. PMID: 11282157.
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    31. Ho W, Uniyal S, Meakin SO, Morris VL, Chan B. A differential role of extracellular signal-regulated kinase in stimulated PC12 pheochromocytoma cell movement. Exp Cell Res. 2001 Feb 15; 263(2):254-64. PMID: 11161724.
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    32. Shenoy PS, Uniyal S, Miura K, McColl C, Oravecz T, Morris VL, Chan B. beta1 Integrin-extracellular matrix protein interaction modulates the migratory response to chemokine stimulation. Biochem Cell Biol. 2001; 79(4):399-407. PMID: 11527209.
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    33. Pickering JG, Chow LH, Li S, Rogers KA, Rocnik EF, Zhong R, Chan B. alpha5beta1 integrin expression and luminal edge fibronectin matrix assembly by smooth muscle cells after arterial injury. Am J Pathol. 2000 Feb; 156(2):453-65. PMID: 10666375; PMCID: PMC1850036.
    34. Probstmeier R, Michels M, Franz T, Chan B, Pesheva P. Tenascin-R interferes with integrin-dependent oligodendrocyte precursor cell adhesion by a ganglioside-mediated signalling mechanism. Eur J Neurosci. 1999 Jul; 11(7):2474-88. PMID: 10383637.
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    35. Fehlner-Gardiner CC, Cao H, Jackson-Boeters L, Nakamura T, Elliott BE, Uniyal S, Chan B. Characterization of a functional relationship between hepatocyte growth factor and mouse bone marrow-derived mast cells. Differentiation. 1999 Jul; 65(1):27-42. PMID: 10448711.
      View in: PubMed
    36. Uniyal S, Boeters L, Chakrabarti S, Singh B, Chan B. Leukocytes utilize both alpha4 and alpha5 integrins for intraislet infiltration in non-obese diabetic mice. J Autoimmun. 1999 May; 12(3):167-76. PMID: 10222026.
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    37. Hangan-Steinman D, Ho WC, Shenoy P, Chan B, Morris VL. Differences in phosphatase modulation of alpha4beta1 and alpha5beta1 integrin-mediated adhesion and migration of B16F1 cells. Biochem Cell Biol. 1999; 77(5):409-20. PMID: 10593604.
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    38. Chan B, Zheng H, Wang H, Uniyal S, Garcia B, Wang J, Zhong R. Treatment of cardiac allografts with established leukocyte infiltration by modulation of alpha4 (CD49d) and leukocyte function-associated antigen-1 (CD11a/CD18) integrin function. Transplantation. 1998 Aug 15; 66(3):277-83. PMID: 9721793.
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    39. Rocnik EF, Chan B, Pickering JG. Evidence for a role of collagen synthesis in arterial smooth muscle cell migration. J Clin Invest. 1998 May 01; 101(9):1889-98. PMID: 9576753; PMCID: PMC508775.
    40. Ho WC, Heinemann C, Hangan D, Uniyal S, Morris VL, Chan B. Modulation of in vivo migratory function of alpha 2 beta 1 integrin in mouse liver. Mol Biol Cell. 1997 Oct; 8(10):1863-75. PMID: 9348529; PMCID: PMC25630.
    41. Hangan D, Morris VL, Boeters L, von Ballestrem C, Uniyal S, Chan B. An epitope on VLA-6 (alpha6beta1) integrin involved in migration but not adhesion is required for extravasation of murine melanoma B16F1 cells in liver. Cancer Res. 1997 Sep 01; 57(17):3812-7. PMID: 9288792.
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    42. Pickering JG, Uniyal S, Ford CM, Chau T, Laurin MA, Chow LH, Ellis CG, Fish J, Chan B. Fibroblast growth factor-2 potentiates vascular smooth muscle cell migration to platelet-derived growth factor: upregulation of alpha2beta1 integrin and disassembly of actin filaments. Circ Res. 1997 May; 80(5):627-37. PMID: 9130443.
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    43. Fehlner-Gardiner CC, Uniyal S, von Ballestrem CG, Chan B. Differential utilization of VLA-4 (alpha 4 beta 1) and -5 (alpha 5 beta 1) integrins during the development of mouse bone marrow-derived mast cells. Differentiation. 1996 Sep; 60(5):317-25. PMID: 8855375.
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    44. Fehlner-Gardiner C, Uniyal S, von Ballestrem C, Dougherty GJ, Chan B. Integrin VLA-6 (alpha 6 beta 1) mediates adhesion of mouse bone marrow-derived mast cells to laminin. Allergy. 1996 Sep; 51(9):650-6. PMID: 8899118.
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    45. Hangan D, Uniyal S, Morris VL, MacDonald IC, von Ballestrem C, Chau T, Schmidt EE, Chambers AF, Groom AC, Chan B. Integrin VLA-2 (alpha2beta1) function in postextravasation movement of human rhabdomyosarcoma RD cells in the liver. Cancer Res. 1996 Jul 01; 56(13):3142-9. PMID: 8674074.
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    46. Von Ballestrem CG, Uniyal S, McCormick JI, Chau T, Singh B, Chan B. VLA-beta 1 integrin subunit-specific monoclonal antibodies MB1.1 and MB1.2: binding to epitopes not dependent on thymocyte development or regulated by phorbol ester and divalent cations. Hybridoma. 1996 Apr; 15(2):125-32. PMID: 8743292.
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    47. Chan B, Ignoffo RJ. Vinorelbine tartrate. Cancer Pract. 1995 Sep-Oct; 3(5):320-3. PMID: 7663552.
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    48. Edelman JM, Chan B, Uniyal S, Onodera H, Wang DZ, St John NF, Damjanovich L, Latzer DB, Finberg RW, Bergelson JM. The mouse VLA-2 homologue supports collagen and laminin adhesion but not virus binding. Cell Adhes Commun. 1994 Jun; 2(2):131-43. PMID: 8081889.
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    49. Bergelson JM, Chan B, Finberg RW, Hemler ME. The integrin VLA-2 binds echovirus 1 and extracellular matrix ligands by different mechanisms. J Clin Invest. 1993 Jul; 92(1):232-9. PMID: 7686920; PMCID: PMC293576.
    50. Chan B, Hemler ME. Multiple functional forms of the integrin VLA-2 can be derived from a single alpha 2 cDNA clone: interconversion of forms induced by an anti-beta 1 antibody. J Cell Biol. 1993 Jan; 120(2):537-43. PMID: 8421065; PMCID: PMC2119525.
    51. Campanero MR, Arroyo AG, Pulido R, Ursa A, de Matías MS, Sánchez-Mateos P, Kassner PD, Chan B, Hemler ME, Corbí AL. Functional role of alpha 2/beta 1 and alpha 4/beta 1 integrins in leukocyte intercellular adhesion induced through the common beta 1 subunit. Eur J Immunol. 1992 Dec; 22(12):3111-9. PMID: 1446704.
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    52. Chan B, Elices MJ, Murphy E, Hemler ME. Adhesion to vascular cell adhesion molecule 1 and fibronectin. Comparison of alpha 4 beta 1 (VLA-4) and alpha 4 beta 7 on the human B cell line JY. J Biol Chem. 1992 Apr 25; 267(12):8366-70. PMID: 1373725.
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    53. Bergelson JM, Shepley MP, Chan B, Hemler ME, Finberg RW. Identification of the integrin VLA-2 as a receptor for echovirus 1. Science. 1992 Mar 27; 255(5052):1718-20. PMID: 1553561.
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    54. Chan B, Kassner PD, Schiro JA, Byers HR, Kupper TS, Hemler ME. Distinct cellular functions mediated by different VLA integrin alpha subunit cytoplasmic domains. Cell. 1992 Mar 20; 68(6):1051-60. PMID: 1547502.
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    55. Kassner PD, Teixido J, Chan B, Parker CM, Hemler ME. Analyses of VLA-4 structure and function. Adv Exp Med Biol. 1992; 323:163-70. PMID: 1283048.
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    56. Hemler ME, Kassner PD, Chan B. Functional roles for integrin alpha subunit cytoplasmic domains. Cold Spring Harb Symp Quant Biol. 1992; 57:213-20. PMID: 1339660.
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    57. Schiro JA, Chan B, Roswit WT, Kassner PD, Pentland AP, Hemler ME, Eisen AZ, Kupper TS. Integrin alpha 2 beta 1 (VLA-2) mediates reorganization and contraction of collagen matrices by human cells. Cell. 1991 Oct 18; 67(2):403-10. PMID: 1913826.
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    58. Chan B, Wong JG, Rao A, Hemler ME. T cell receptor-dependent, antigen-specific stimulation of a murine T cell clone induces a transient, VLA protein-mediated binding to extracellular matrix. J Immunol. 1991 Jul 15; 147(2):398-404. PMID: 2071890.
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    59. Zheng YL, Chan B, Rector ES, Berczi I, Froese A. Establishment and characterization of hybrid rat mast cells. Exp Cell Res. 1991 Jun; 194(2):301-9. PMID: 1827410.
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    60. Chan B, Matsuura N, Takada Y, Zetter BR, Hemler ME. In vitro and in vivo consequences of VLA-2 expression on rhabdomyosarcoma cells. Science. 1991 Mar 29; 251(5001):1600-2. PMID: 2011740.
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    61. Hemler ME, Elices MJ, Chan B, Zetter B, Matsuura N, Takada Y. Multiple ligand binding functions for VLA-2 (alpha 2 beta 1) and VLA-3 (alpha 3 beta 1) in the integrin family. Cell Differ Dev. 1990 Dec 02; 32(3):229-38. PMID: 1965952.
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    62. Ria F, Chan B, Scherer MT, Smith JA, Gefter ML. Immunological activity of covalently linked T-cell epitopes. Nature. 1990 Jan 25; 343(6256):381-3. PMID: 1689012.
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    63. Chan B, Ra CS, Hu WN, McNeill K, Miller HR, Befus D, Kinet JP, Froese A. Characterization of rat tissue cultured mast cells. Eur J Immunol. 1990 Jan; 20(1):185-93. PMID: 2137780.
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    64. Hu W, Chan B, Froese A. Differential IgE receptor development on rat tissue cultured mast cells. Int Arch Allergy Appl Immunol. 1990; 92(3):301-5. PMID: 2148930.
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    65. Swieter M, Chan B, Rimmer C, McNeill K, Froese A, Befus D. Isolation and characterization of IgE receptors from rat intestinal mucosal mast cells. Eur J Immunol. 1989 Oct; 19(10):1879-85. PMID: 2531089.
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    66. Scherer MT, Chan B, Ria F, Smith JA, Perkins DL, Gefter ML. Control of cellular and humoral immune responses by peptides containing T-cell epitopes. Cold Spring Harb Symp Quant Biol. 1989; 54 Pt 1:497-504. PMID: 2484168.
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    67. Swieter M, Chan B, Lee TD, Rimmer CJ, Froese A, Befus D. IgE receptors from rat intestinal mucosal and peritoneal mast cells show mast cell subtype-specific differences. Int Arch Allergy Appl Immunol. 1989; 88(1-2):200-2. PMID: 2523356.
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    68. Chan B, McNeill K, Froese A. Factor-independent tissue cultured mast cells: establishment from rat peritoneal mast cells. Immunol Lett. 1988 May; 18(1):37-42. PMID: 2454219.
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    69. Chan B, Froese A. Mycoplasma-induced degradation of IgE bound by Fc epsilon receptors of rat basophilic leukemia cells. Eur J Immunol. 1987 May; 17(5):637-42. PMID: 2953615.
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    70. Chan B, McNeill K, Berczi I, Froese A. Effects of mycoplasma infection on Fc receptors for IgE of rat basophilic leukemia cells. Eur J Immunol. 1986 Nov; 16(11):1319-24. PMID: 2946588.
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    71. Brash JL, Chan B, Szota P, Thibodeau JA. Degradation of adsorbed fibrinogen by surface-generated plasmin. J Biomed Mater Res. 1985 Nov-Dec; 19(9):1017-29. PMID: 2935535.
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