Baruch Frenkel, DMD, PhD

TitleProfessor of Orthopaedic Surgery
InstitutionUniversity of Southern California
DepartmentOrthopaedic Surgery
AddressCSC 240 2250 Alcazar Street
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 1322
vCardDownload vCard
    Other Positions
    TitleJ. Harold and Edna L. LaBriola Chair in Genetic Orthopaedic Research

    Collapse Overview 
    Collapse Overview
    We are a basic science lab, interested in transcriptional control (in particular combinatorial transcriptional control of mammalian gene expression), steroid hormone signaling, and cell biology (including stem cells and cell cycle control). All of our projects have significant clinical implications. Many of them start with high throughput genomic approaches to identify novel pathways in various human diseases, and continue with more traditional cellular and molecular approaches to investigate disease mechanisms in depth. A theme overarching most of the projects in the lab is interactions between steroid hormone receptors and RUNX proteins, for example: 1) Role of RUNX2 in glucocorticoid-induced osteoporosis; 2) Role of RUNX2 in bone-sparing effects of estrogens, androgens and SERMs; 3) Role of RUNX2 in prostate cancer and breast cancer metastasis in general and bone metastasis in particular; and 4) Context-dependent roles of RUNX proteins, in particular RUNX1, in breast cancer suppression and promotion.

    Collapse Research 
    Collapse Research Activities and Funding
    Modulation of RUNX2 Activity by ERa in Osteoblasts
    NIH/NIDDK R56DK071122Apr 1, 2005 - Jul 31, 2018
    Role: Principal Investigator
    Sex Steroids and Runx Signaling in Bone
    NIH/NIDDK R01DK071122Apr 1, 2005 - Jun 30, 2014
    Role: Principal Investigator
    Identification of CBFA1 Targets in Osteoblasts
    NIH/NIAMS R21AR049297Sep 23, 2002 - May 31, 2005
    Role: Principal Investigator
    NIH/NIAMS R01AR047052Sep 1, 2000 - Jul 31, 2012
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Amzaleg Y, Ji J, Kittivanichkul D, E Törnqvist A, Windahl S, Sabag E, Khalid AB, Sternberg H, West M, Katzenellenbogen JA, Krum SA, Chimge NO, Schones DE, Gabet Y, Ohlsson C, Frenkel B. Estrogens and selective estrogen receptor modulators differentially antagonize Runx2 in ST2 mesenchymal progenitor cells. J Steroid Biochem Mol Biol. 2018 May 08. PMID: 29751107.
      View in: PubMed
    2. Martin A, Yu J, Xiong J, Khalid AB, Katzenellenbogen B, Kim SH, Katzenellenbogen JA, Malaivijitnond S, Gabet Y, Krum SA, Frenkel B. Estrogens and androgens inhibit association of RANKL with the pre-osteoblast membrane through post-translational mechanisms. J Cell Physiol. 2017 Dec; 232(12):3798-3807. PMID: 28213978.
      View in: PubMed
    3. Chimge NO, Ahmed-Alnassar S, Frenkel B. Relationship between RUNX1 and AXIN1 in ER-negative versus ER-positive Breast Cancer. Cell Cycle. 2017 Feb 16; 16(4):312-318. PMID: 28055379.
      View in: PubMed
    4. Vuong W, Tew BY, Little GH, Frenkel B, Jones JO. High-Throughput Screen for Inhibitors of Androgen Receptor-RUNX2 Transcriptional Regulation in Prostate Cancer. J Pharmacol Exp Ther. 2016 Nov; 359(2):256-261. PMID: 27554677.
      View in: PubMed
    5. Yang Y, He S, Wang Q, Li F, Kwak MJ, Chen S, O'Connell D, Zhang T, Pirooz SD, Jeon Y, Chimge NO, Frenkel B, Choi Y, Aldrovandi GM, Oh BH, Yuan Z, Liang C. Autophagic UVRAG Promotes UV-Induced Photolesion Repair by Activation of the CRL4(DDB2) E3 Ligase. Mol Cell. 2016 05 19; 62(4):507-19. PMID: 27203177; PMCID: PMC4875571 [Available on 05/19/17].
    6. Morimoto E, Li M, Khalid AB, Krum SA, Chimge NO, Frenkel B. Glucocorticoids Hijack Runx2 to Stimulate Wif1 for Suppression of Osteoblast Growth and Differentiation. J Cell Physiol. 2017 Jan; 232(1):145-53. PMID: 27061521.
      View in: PubMed
    7. Chimge NO, Little GH, Baniwal SK, Adisetiyo H, Xie Y, Zhang T, O'Laughlin A, Liu ZY, Ulrich P, Martin A, Mhawech-Fauceglia P, Ellis MJ, Tripathy D, Groshen S, Liang C, Li Z, Schones DE, Frenkel B. RUNX1 prevents oestrogen-mediated AXIN1 suppression and ß-catenin activation in ER-positive breast cancer. Nat Commun. 2016 Feb 26; 7:10751. PMID: 26916619; PMCID: PMC4773428.
    8. HaDuong JH, Blavier L, Baniwal SK, Frenkel B, Malvar J, Punj V, Sposto R, DeClerck YA. Interaction between bone marrow stromal cells and neuroblastoma cells leads to a VEGFA-mediated osteoblastogenesis. Int J Cancer. 2015 Aug 15; 137(4):797-809. PMID: 25648303.
      View in: PubMed
    9. Martin A, Xiong J, Koromila T, Ji JS, Chang S, Song YS, Miller JL, Han CY, Kostenuik P, Krum SA, Chimge NO, Gabet Y, Frenkel B. Estrogens antagonize RUNX2-mediated osteoblast-driven osteoclastogenesis through regulating RANKL membrane association. Bone. 2015 Jun; 75:96-104. PMID: 25701138; PMCID: PMC4387095.
    10. Yu JL, Adisetiyo H, Little GH, Vangsness CT, Jiang J, Sternberg H, West MD, Frenkel B. Initial Characterization of Osteoblast Differentiation and Loss of RUNX2 Stability in the Newly Established SK11 Human Embryonic Stem Cell-Derived Cell Line. J Cell Physiol. 2015 Feb; 230(2):237-41. PMID: 25160731.
      View in: PubMed
    11. Frenkel B, White W, Tuckermann J. Glucocorticoid-Induced Osteoporosis. Adv Exp Med Biol. 2015; 872:179-215. PMID: 26215995.
      View in: PubMed
    12. Adisetiyo H, Liang M, Liao CP, Jeong JH, Cohen MB, Roy-Burman P, Frenkel B. Dependence of castration-resistant prostate cancer (CRPC) stem cells on CRPC-associated fibroblasts. J Cell Physiol. 2014 Sep; 229(9):1170-6. PMID: 24752784.
      View in: PubMed
    13. Little GH, Baniwal SK, Adisetiyo H, Groshen S, Chimge NO, Kim SY, Khalid O, Hawes D, Jones JO, Pinski J, Schones DE, Frenkel B. Differential effects of RUNX2 on the androgen receptor in prostate cancer: synergistic stimulation of a gene set exemplified by SNAI2 and subsequent invasiveness. Cancer Res. 2014 May 15; 74(10):2857-68. PMID: 24648349; PMCID: PMC4051204.
    14. Soung do Y, Kalinowski J, Baniwal SK, Jacome-Galarza CE, Frenkel B, Lorenzo J, Drissi H. Runx1-mediated regulation of osteoclast differentiation and function. Mol Endocrinol. 2014 Apr; 28(4):546-53. PMID: 24606124; PMCID: PMC3968404.
    15. Koromila T, Baniwal SK, Song YS, Martin A, Xiong J, Frenkel B. Glucocorticoids antagonize RUNX2 during osteoblast differentiation in cultures of ST2 pluripotent mesenchymal cells. J Cell Biochem. 2014 Jan; 115(1):27-33. PMID: 23943595.
      View in: PubMed
    16. Pham LK, Liang M, Adisetiyo HA, Liao CP, Cohen MB, Tahara SM, Frenkel B, Kasahara N, Roy-Burman P. Contextual effect of repression of bone morphogenetic protein activity in prostate cancer. Endocr Relat Cancer. 2013 Dec; 20(6):861-74. PMID: 24042462; PMCID: PMC3885249.
    17. Baniwal SK, Chimge NO, Jordan VC, Tripathy D, Frenkel B. Prolactin-induced protein (PIP) regulates proliferation of luminal A type breast cancer cells in an estrogen-independent manner. PLoS One. 2014; 8(6):e62361. PMID: 23755096; PMCID: PMC3670933.
    18. Windahl SH, Saxon L, Börjesson AE, Lagerquist MK, Frenkel B, Henning P, Lerner UH, Galea GL, Meakin LB, Engdahl C, Sjögren K, Antal MC, Krust A, Chambon P, Lanyon LE, Price JS, Ohlsson C. Estrogen receptor-a is required for the osteogenic response to mechanical loading in a ligand-independent manner involving its activation function 1 but not 2. J Bone Miner Res. 2013 Feb; 28(2):291-301. PMID: 22972752; PMCID: PMC3575695.
    19. Purcell DJ, Khalid O, Ou CY, Little GH, Frenkel B, Baniwal SK, Stallcup MR. Recruitment of coregulator G9a by Runx2 for selective enhancement or suppression of transcription. J Cell Biochem. 2012 Jul; 113(7):2406-14. PMID: 22389001; PMCID: PMC3350606.
    20. Baniwal SK, Little GH, Chimge NO, Frenkel B. Runx2 controls a feed-forward loop between androgen and prolactin-induced protein (PIP) in stimulating T47D cell proliferation. J Cell Physiol. 2012 May; 227(5):2276-82. PMID: 21809344; PMCID: PMC3376385.
    21. Yen HY, Gabet Y, Liu Y, Martin A, Wu NL, Pike MC, Frenkel B, Maxson R, Dubeau L. Alterations in Brca1 expression in mouse ovarian granulosa cells have short-term and long-term consequences on estrogen-responsive organs. Lab Invest. 2012 Jun; 92(6):802-11. PMID: 22488153; PMCID: PMC4530993.
    22. Ting MC, Liao CP, Yan C, Jia L, Groshen S, Frenkel B, Roy-Burman P, Coetzee GA, Maxson R. An enhancer from the 8q24 prostate cancer risk region is sufficient to direct reporter gene expression to a subset of prostate stem-like epithelial cells in transgenic mice. Dis Model Mech. 2012 May; 5(3):366-74. PMID: 22279083; PMCID: PMC3339830.
    23. Little GH, Noushmehr H, Baniwal SK, Berman BP, Coetzee GA, Frenkel B. Genome-wide Runx2 occupancy in prostate cancer cells suggests a role in regulating secretion. Nucleic Acids Res. 2012 Apr; 40(8):3538-47. PMID: 22187159; PMCID: PMC3333873.
    24. Chimge NO, Baniwal SK, Little GH, Chen YB, Kahn M, Tripathy D, Borok Z, Frenkel B. Regulation of breast cancer metastasis by Runx2 and estrogen signaling: the role of SNAI2. Breast Cancer Res. 2011; 13(6):R127. PMID: 22151997; PMCID: PMC3326569.
    25. Chimge NO, Baniwal SK, Luo J, Coetzee S, Khalid O, Berman BP, Tripathy D, Ellis MJ, Frenkel B. Opposing effects of Runx2 and estradiol on breast cancer cell proliferation: in vitro identification of reciprocally regulated gene signature related to clinical letrozole responsiveness. Clin Cancer Res. 2012 Feb 01; 18(3):901-11. PMID: 22147940; PMCID: PMC3277803.
    26. Andreu-Vieyra C, Lai J, Berman BP, Frenkel B, Jia L, Jones PA, Coetzee GA. Dynamic nucleosome-depleted regions at androgen receptor enhancers in the absence of ligand in prostate cancer cells. Mol Cell Biol. 2011 Dec; 31(23):4648-62. PMID: 21969603; PMCID: PMC3232925.
    27. Gabet Y, Noh T, Lee C, Frenkel B. Developmentally regulated inhibition of cell cycle progression by glucocorticoids through repression of cyclin A transcription in primary osteoblast cultures. J Cell Physiol. 2011 Apr; 226(4):991-8. PMID: 20857405.
      View in: PubMed
    28. Börjesson AE, Windahl SH, Lagerquist MK, Engdahl C, Frenkel B, Movérare-Skrtic S, Sjögren K, Kindblom JM, Stubelius A, Islander U, Antal MC, Krust A, Chambon P, Ohlsson C. Roles of transactivating functions 1 and 2 of estrogen receptor-alpha in bone. Proc Natl Acad Sci U S A. 2011 Apr 12; 108(15):6288-93. PMID: 21444817; PMCID: PMC3076831.
    29. Ofek O, Attar-Namdar M, Kram V, Dvir-Ginzberg M, Mechoulam R, Zimmer A, Frenkel B, Shohami E, Bab I. CB2 cannabinoid receptor targets mitogenic Gi protein-cyclin D1 axis in osteoblasts. J Bone Miner Res. 2011 Feb; 26(2):308-16. PMID: 20803555; PMCID: PMC3179350.
    30. Baniwal SK, Khalid O, Gabet Y, Shah RR, Purcell DJ, Mav D, Kohn-Gabet AE, Shi Y, Coetzee GA, Frenkel B. Runx2 transcriptome of prostate cancer cells: insights into invasiveness and bone metastasis. Mol Cancer. 2010 Sep 23; 9:258. PMID: 20863401; PMCID: PMC2955618.
    31. Gabet Y, Baniwal SK, Leclerc N, Shi Y, Kohn-Gabet AE, Cogan J, Dixon A, Bachar M, Guo L, Turman JE, Frenkel B. Krox20/EGR2 deficiency accelerates cell growth and differentiation in the monocytic lineage and decreases bone mass. Blood. 2010 Nov 11; 116(19):3964-71. PMID: 20716776; PMCID: PMC2981544.
    32. Frenkel B, Hong A, Baniwal SK, Coetzee GA, Ohlsson C, Khalid O, Gabet Y. Regulation of adult bone turnover by sex steroids. J Cell Physiol. 2010 Aug; 224(2):305-10. PMID: 20432458.
      View in: PubMed
    33. Berman BP, Frenkel B, Coetzee GA, Jia L. Androgen receptor responsive enhancers are flanked by consistently-positioned H3-acetylated nucleosomes. Cell Cycle. 2010 Jun 01; 9(11):2249-50. PMID: 20495358; PMCID: PMC4373526.
    34. Coetzee GA, Jia L, Frenkel B, Henderson BE, Tanay A, Haiman CA, Freedman ML. A systematic approach to understand the functional consequences of non-protein coding risk regions. Cell Cycle. 2010 Jan 15; 9(2):256-9. PMID: 20023379; PMCID: PMC3319348.
    35. Jia L, Landan G, Pomerantz M, Jaschek R, Herman P, Reich D, Yan C, Khalid O, Kantoff P, Oh W, Manak JR, Berman BP, Henderson BE, Frenkel B, Haiman CA, Freedman M, Tanay A, Coetzee GA. Functional enhancers at the gene-poor 8q24 cancer-linked locus. PLoS Genet. 2009 Aug; 5(8):e1000597. PMID: 19680443; PMCID: PMC2717370.
    36. Warotayanont R, Frenkel B, Snead ML, Zhou Y. Leucine-rich amelogenin peptide induces osteogenesis by activation of the Wnt pathway. Biochem Biophys Res Commun. 2009 Sep 25; 387(3):558-63. PMID: 19615979; PMCID: PMC2758297.
    37. Pomerantz MM, Ahmadiyeh N, Jia L, Herman P, Verzi MP, Doddapaneni H, Beckwith CA, Chan JA, Hills A, Davis M, Yao K, Kehoe SM, Lenz HJ, Haiman CA, Yan C, Henderson BE, Frenkel B, Barretina J, Bass A, Tabernero J, Baselga J, Regan MM, Manak JR, Shivdasani R, Coetzee GA, Freedman ML. The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer. Nat Genet. 2009 Aug; 41(8):882-4. PMID: 19561607; PMCID: PMC2763485.
    38. Noh T, Gabet Y, Cogan J, Shi Y, Tank A, Sasaki T, Criswell B, Dixon A, Lee C, Tam J, Kohler T, Segev E, Kockeritz L, Woodgett J, Müller R, Chai Y, Smith E, Bab I, Frenkel B. Lef1 haploinsufficient mice display a low turnover and low bone mass phenotype in a gender- and age-specific manner. PLoS One. 2009; 4(5):e5438. PMID: 19412553; PMCID: PMC2673053.
    39. Berman BP, Frenkel B, Coetzee GA. Location, location, (ChIP-)location! Mapping chromatin landscapes one immunoprecipitation at a time. J Cell Biochem. 2009 May 01; 107(1):1-5. PMID: 19308935; PMCID: PMC2748114.
    40. Baniwal SK, Khalid O, Sir D, Buchanan G, Coetzee GA, Frenkel B. Repression of Runx2 by androgen receptor (AR) in osteoblasts and prostate cancer cells: AR binds Runx2 and abrogates its recruitment to DNA. Mol Endocrinol. 2009 Aug; 23(8):1203-14. PMID: 19389811; PMCID: PMC2718746.
    41. Jariwala U, Cogan JP, Jia L, Frenkel B, Coetzee GA. Inhibition of AR-mediated transcription by binding of Oct1 to a motif enriched in AR-occupied regions. Prostate. 2009 Mar 01; 69(4):392-400. PMID: 19058140; PMCID: PMC2743387.
    42. Jia L, Berman BP, Jariwala U, Yan X, Cogan JP, Walters A, Chen T, Buchanan G, Frenkel B, Coetzee GA. Genomic androgen receptor-occupied regions with different functions, defined by histone acetylation, coregulators and transcriptional capacity. PLoS One. 2008; 3(11):e3645. PMID: 18997859; PMCID: PMC2577007.
    43. Pregizer S, Baniwal SK, Yan X, Borok Z, Frenkel B. Progressive recruitment of Runx2 to genomic targets despite decreasing expression during osteoblast differentiation. J Cell Biochem. 2008 Nov 01; 105(4):965-70. PMID: 18821584; PMCID: PMC2591066.
    44. Zhou B, Francis TA, Yang H, Tseng W, Zhong Q, Frenkel B, Morrisey EE, Ann DK, Minoo P, Crandall ED, Borok Z. GATA-6 mediates transcriptional activation of aquaporin-5 through interactions with Sp1. Am J Physiol Cell Physiol. 2008 Nov; 295(5):C1141-50. PMID: 18768929; PMCID: PMC2584994.
    45. Khalid O, Baniwal SK, Purcell DJ, Leclerc N, Gabet Y, Stallcup MR, Coetzee GA, Frenkel B. Modulation of Runx2 activity by estrogen receptor-alpha: implications for osteoporosis and breast cancer. Endocrinology. 2008 Dec; 149(12):5984-95. PMID: 18755791; PMCID: PMC2613062.
    46. Luppen CA, Chandler RL, Noh T, Mortlock DP, Frenkel B. BMP-2 vs. BMP-4 expression and activity in glucocorticoid-arrested MC3T3-E1 osteoblasts: Smad signaling, not alkaline phosphatase activity, predicts rescue of mineralization. Growth Factors. 2008 Aug; 26(4):226-37. PMID: 19021035; PMCID: PMC3760374.
    47. Leclerc N, Noh T, Cogan J, Samarawickrama DB, Smith E, Frenkel B. Opposing effects of glucocorticoids and Wnt signaling on Krox20 and mineral deposition in osteoblast cultures. J Cell Biochem. 2008 Apr 15; 103(6):1938-51. PMID: 17973254.
      View in: PubMed
    48. Zhou B, Zhong Q, Minoo P, Li C, Ann DK, Frenkel B, Morrisey EE, Crandall ED, Borok Z. Foxp2 inhibits Nkx2.1-mediated transcription of SP-C via interactions with the Nkx2.1 homeodomain. Am J Respir Cell Mol Biol. 2008 Jun; 38(6):750-8. PMID: 18239190; PMCID: PMC2396252.
    49. Barski A, Pregizer S, Frenkel B. Identification of transcription factor target genes by ChIP display. Methods Mol Biol. 2008; 455:177-90. PMID: 18463820.
      View in: PubMed
    50. Yang S, Pham LK, Liao CP, Frenkel B, Reddi AH, Roy-Burman P. A novel bone morphogenetic protein signaling in heterotypic cell interactions in prostate cancer. Cancer Res. 2008 Jan 01; 68(1):198-205. PMID: 18172312.
      View in: PubMed
    51. Pregizer S, Barski A, Gersbach CA, García AJ, Frenkel B. Identification of novel Runx2 targets in osteoblasts: cell type-specific BMP-dependent regulation of Tram2. J Cell Biochem. 2007 Dec 15; 102(6):1458-71. PMID: 17486635.
      View in: PubMed
    52. Prescott J, Jariwala U, Jia L, Cogan JP, Barski A, Pregizer S, Shen HC, Arasheben A, Neilson JJ, Frenkel B, Coetzee GA. Androgen receptor-mediated repression of novel target genes. Prostate. 2007 Sep 15; 67(13):1371-83. PMID: 17624924.
      View in: PubMed
    53. Jariwala U, Prescott J, Jia L, Barski A, Pregizer S, Cogan JP, Arasheben A, Tilley WD, Scher HI, Gerald WL, Buchanan G, Coetzee GA, Frenkel B. Identification of novel androgen receptor target genes in prostate cancer. Mol Cancer. 2007 Jun 06; 6:39. PMID: 17553165; PMCID: PMC1904239.
    54. Zhu W, Boachie-Adjei O, Rawlins BA, Frenkel B, Boskey AL, Ivashkiv LB, Blobel CP. A novel regulatory role for stromal-derived factor-1 signaling in bone morphogenic protein-2 osteogenic differentiation of mesenchymal C2C12 cells. J Biol Chem. 2007 Jun 29; 282(26):18676-85. PMID: 17439946.
      View in: PubMed
    55. Ofek O, Karsak M, Leclerc N, Fogel M, Frenkel B, Wright K, Tam J, Attar-Namdar M, Kram V, Shohami E, Mechoulam R, Zimmer A, Bab I. Peripheral cannabinoid receptor, CB2, regulates bone mass. Proc Natl Acad Sci U S A. 2006 Jan 17; 103(3):696-701. PMID: 16407142; PMCID: PMC1334629.
    56. Miguel SM, Namdar-Attar M, Noh T, Frenkel B, Bab I. ERK1/2-activated de novo Mapkapk2 synthesis is essential for osteogenic growth peptide mitogenic signaling in osteoblastic cells. J Biol Chem. 2005 Nov 11; 280(45):37495-502. PMID: 16150701.
      View in: PubMed
    57. Yang S, Zhong C, Frenkel B, Reddi AH, Roy-Burman P. Diverse biological effect and Smad signaling of bone morphogenetic protein 7 in prostate tumor cells. Cancer Res. 2005 Jul 01; 65(13):5769-77. PMID: 15994952.
      View in: PubMed
    58. Leclerc N, Noh T, Khokhar A, Smith E, Frenkel B. Glucocorticoids inhibit osteocalcin transcription in osteoblasts by suppressing Egr2/Krox20-binding enhancer. Arthritis Rheum. 2005 Mar; 52(3):929-39. PMID: 15751078.
      View in: PubMed
    59. Smith E, Meyerrose TE, Kohler T, Namdar-Attar M, Bab N, Lahat O, Noh T, Li J, Karaman MW, Hacia JG, Chen TT, Nolta JA, Müller R, Bab I, Frenkel B. Leaky ribosomal scanning in mammalian genomes: significance of histone H4 alternative translation in vivo. Nucleic Acids Res. 2005; 33(4):1298-308. PMID: 15741183; PMCID: PMC552952.
    60. Smith E, Frenkel B. Glucocorticoids inhibit the transcriptional activity of LEF/TCF in differentiating osteoblasts in a glycogen synthase kinase-3beta-dependent and -independent manner. J Biol Chem. 2005 Jan 21; 280(3):2388-94. PMID: 15537647.
      View in: PubMed
    61. Leclerc N, Luppen CA, Ho VV, Nagpal S, Hacia JG, Smith E, Frenkel B. Gene expression profiling of glucocorticoid-inhibited osteoblasts. J Mol Endocrinol. 2004 Aug; 33(1):175-93. PMID: 15291752.
      View in: PubMed
    62. Barski A, Frenkel B. ChIP Display: novel method for identification of genomic targets of transcription factors. Nucleic Acids Res. 2004 Jul 13; 32(12):e104. PMID: 15252151; PMCID: PMC484196.
    63. Luppen CA, Leclerc N, Noh T, Barski A, Khokhar A, Boskey AL, Smith E, Frenkel B. Brief bone morphogenetic protein 2 treatment of glucocorticoid-inhibited MC3T3-E1 osteoblasts rescues commitment-associated cell cycle and mineralization without alteration of Runx2. J Biol Chem. 2003 Nov 07; 278(45):44995-5003. PMID: 12933820.
      View in: PubMed
    64. Luppen CA, Smith E, Spevak L, Boskey AL, Frenkel B. Bone morphogenetic protein-2 restores mineralization in glucocorticoid-inhibited MC3T3-E1 osteoblast cultures. J Bone Miner Res. 2003 Jul; 18(7):1186-97. PMID: 12854828.
      View in: PubMed
    65. Zalavras C, Shah S, Birnbaum MJ, Frenkel B. Role of apoptosis in glucocorticoid-induced osteoporosis and osteonecrosis. Crit Rev Eukaryot Gene Expr. 2003; 13(2-4):221-35. PMID: 14696969.
      View in: PubMed
    66. Smith E, Coetzee GA, Frenkel B. Glucocorticoids inhibit cell cycle progression in differentiating osteoblasts via glycogen synthase kinase-3beta. J Biol Chem. 2002 May 17; 277(20):18191-7. PMID: 11877389.
      View in: PubMed
    67. Hou Z, Nguyen Q, Frenkel B, Nilsson SK, Milne M, van Wijnen AJ, Stein JL, Quesenberry P, Lian JB, Stein GS. Osteoblast-specific gene expression after transplantation of marrow cells: implications for skeletal gene therapy. Proc Natl Acad Sci U S A. 1999 Jun 22; 96(13):7294-9. PMID: 10377408; PMCID: PMC22079.
    68. Bab I, Smith E, Gavish H, Attar-Namdar M, Chorev M, Chen YC, Muhlrad A, Birnbaum MJ, Stein G, Frenkel B. Biosynthesis of osteogenic growth peptide via alternative translational initiation at AUG85 of histone H4 mRNA. J Biol Chem. 1999 May 14; 274(20):14474-81. PMID: 10318873.
      View in: PubMed
    69. Nilsson SK, Dooner MS, Weier HU, Frenkel B, Lian JB, Stein GS, Quesenberry PJ. Cells capable of bone production engraft from whole bone marrow transplants in nonablated mice. J Exp Med. 1999 Feb 15; 189(4):729-34. PMID: 9989988; PMCID: PMC2192923.
    70. Montecino M, Frenkel B, van Wijnen AJ, Lian JB, Stein GS, Stein JL. Chromatin hyperacetylation abrogates vitamin D-mediated transcriptional upregulation of the tissue-specific osteocalcin gene in vivo. Biochemistry. 1999 Jan 26; 38(4):1338-45. PMID: 9930996.
      View in: PubMed
    71. Aslam F, McCabe L, Frenkel B, van Wijnen AJ, Stein GS, Lian JB, Stein JL. AP-1 and vitamin D receptor (VDR) signaling pathways converge at the rat osteocalcin VDR element: requirement for the internal activating protein-1 site for vitamin D-mediated trans-activation. Endocrinology. 1999 Jan; 140(1):63-70. PMID: 9886808.
      View in: PubMed
    72. Ryoo HM, Hoffmann HM, Beumer T, Frenkel B, Towler DA, Stein GS, Stein JL, van Wijnen AJ, Lian JB. Stage-specific expression of Dlx-5 during osteoblast differentiation: involvement in regulation of osteocalcin gene expression. Mol Endocrinol. 1997 Oct; 11(11):1681-94. PMID: 9328350.
      View in: PubMed
    73. Smith E, Frenkel B, MacLachlan TK, Giordano A, Stein JL, Lian JB, Stein GS. Post-proliferative cyclin E-associated kinase activity in differentiated osteoblasts: inhibition by proliferating osteoblasts and osteosarcoma cells. J Cell Biochem. 1997 Aug 01; 66(2):141-52. PMID: 9213216.
      View in: PubMed
    74. Frenkel B, Capparelli C, Van Auken M, Baran D, Bryan J, Stein JL, Stein GS, Lian JB. Activity of the osteocalcin promoter in skeletal sites of transgenic mice and during osteoblast differentiation in bone marrow-derived stromal cell cultures: effects of age and sex. Endocrinology. 1997 May; 138(5):2109-16. PMID: 9112411.
      View in: PubMed
    75. Lian JB, Shalhoub V, Aslam F, Frenkel B, Green J, Hamrah M, Stein GS, Stein JL. Species-specific glucocorticoid and 1,25-dihydroxyvitamin D responsiveness in mouse MC3T3-E1 osteoblasts: dexamethasone inhibits osteoblast differentiation and vitamin D down-regulates osteocalcin gene expression. Endocrinology. 1997 May; 138(5):2117-27. PMID: 9112412.
      View in: PubMed
    76. Guo B, Aslam F, van Wijnen AJ, Roberts SG, Frenkel B, Green MR, DeLuca H, Lian JB, Stein GS, Stein JL. YY1 regulates vitamin D receptor/retinoid X receptor mediated transactivation of the vitamin D responsive osteocalcin gene. Proc Natl Acad Sci U S A. 1997 Jan 07; 94(1):121-6. PMID: 8990171; PMCID: PMC19252.
    77. Montecino M, Frenkel B, Lian J, Stein J, Stein G. Requirement of distal and proximal promoter sequences for chromatin organization of the osteocalcin gene in bone-derived cells. J Cell Biochem. 1996 Nov 01; 63(2):221-8. PMID: 8913873.
      View in: PubMed
    78. Banerjee C, Stein JL, Van Wijnen AJ, Frenkel B, Lian JB, Stein GS. Transforming growth factor-beta 1 responsiveness of the rat osteocalcin gene is mediated by an activator protein-1 binding site. Endocrinology. 1996 May; 137(5):1991-2000. PMID: 8612540.
      View in: PubMed
    79. Frenkel B, Montecino M, Green J, Aslam F, Desai R, Banerjee C, Stein JL, Lian JB, Stein GS. Basal and vitamin D-responsive activity of the rat osteocalcin promoter in stably transfected osteosarcoma cells: requirement of upstream sequences for control by the proximal regulatory domain. Endocrinology. 1996 Mar; 137(3):1080-88. PMID: 8603577.
      View in: PubMed
    80. Smith E, Frenkel B, Schlegel R, Giordano A, Lian JB, Stein JL, Stein GS. Expression of cell cycle regulatory factors in differentiating osteoblasts: postproliferative up-regulation of cyclins B and E. Cancer Res. 1995 Nov 01; 55(21):5019-24. PMID: 7585545.
      View in: PubMed
    81. Birnbaum MJ, Wright KL, van Wijnen AJ, Ramsey-Ewing AL, Bourke MT, Last TJ, Aziz F, Frenkel B, Rao BR, Aronin N. Functional role for Sp1 in the transcriptional amplification of a cell cycle regulated histone H4 gene. Biochemistry. 1995 Jun 13; 34(23):7648-58. PMID: 7779811.
      View in: PubMed
    82. Frenkel B, Montecino M, Stein JL, Lian JB, Stein GS. A composite intragenic silencer domain exhibits negative and positive transcriptional control of the bone-specific osteocalcin gene: promoter and cell type requirements. Proc Natl Acad Sci U S A. 1994 Nov 08; 91(23):10923-7. PMID: 7971985; PMCID: PMC45138.
    83. Frenkel B, Bishara-Shieban J, Bar-Tana J. The effect of beta,beta'-tetramethylhexadecanedioic acid (MEDICA 16) on plasma very-low-density lipoprotein metabolism in rats: role of apolipoprotein C-III. Biochem J. 1994 Mar 01; 298 ( Pt 2):409-14. PMID: 8135749; PMCID: PMC1137955.
    84. Frenkel B, Mijnes J, Aronow MA, Zambetti G, Banerjee C, Stein JL, Lian JB, Stein GS. Position and orientation-selective silencer in protein-coding sequences of the rat osteocalcin gene. Biochemistry. 1993 Dec 14; 32(49):13636-43. PMID: 7504955.
      View in: PubMed
    85. Frenkel B, Mayorek N, Hertz R, Bar-Tana J. The hypochylomicronemic effect of beta,beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) is mediated by a decrease in apolipoprotein C-III. J Biol Chem. 1988 Jun 15; 263(17):8491-7. PMID: 3372539.
      View in: PubMed
    86. Bar-Tana J, Rose-Kahn G, Frenkel B, Shafer Z, Fainaru M. Hypolipidemic effect of beta, beta'-methyl-substituted hexadecanedioic acid (MEDICA 16) in normal and nephrotic rats. J Lipid Res. 1988 Apr; 29(4):431-41. PMID: 3392461.
      View in: PubMed