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Axel Montagne, PhD

Title(s)Associate Professor of Research Physiology & Neuroscience
AddressZNI 301, 1501 San Pablo Street
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 2565
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    Other Positions
    Title(s)Assistant Director, Functional Biological Imaging Core


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    Collapse Awards and Honors
    Alzheimer's Los Angeles 2019Young Investigator Award
    BrightFocus Foundation2019  - 2022BrighFocus Foundation Award (CoPI Bonnin)
    USC ADRC2019  - 2021ADRC Pilot Project
    Fondation Leducq Transatlantic Network of Excellence “Perivascular Spaces in Small Vessel Disease”2019Leducq Pilot Fund

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline. Nature. 2020 05; 581(7806):71-76. Montagne A, Nation DA, Sagare AP, Barisano G, Sweeney MD, Chakhoyan A, Pachicano M, Joe E, Nelson AR, D'Orazio LM, Buennagel DP, Harrington MG, Benzinger TLS, Fagan AM, Ringman JM, Schneider LS, Morris JC, Reiman EM, Caselli RJ, Chui HC, Tcw J, Chen Y, Pa J, Conti PS, Law M, Toga AW, Zlokovic BV. PMID: 32376954.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    2. A novel sensitive assay for detection of a biomarker of pericyte injury in cerebrospinal fluid. Alzheimers Dement. 2020 06; 16(6):821-830. Sweeney MD, Sagare AP, Pachicano M, Harrington MG, Joe E, Chui HC, Schneider LS, Montagne A, Ringman JM, Fagan AM, Morris JC, Pa J, Nation DA, Toga AW, Zlokovic BV. PMID: 32301266.
      View in: PubMed   Mentions:    Fields:    
    3. Perivascular spaces in the brain: anatomy, physiology and pathology. Nat Rev Neurol. 2020 03; 16(3):137-153. Wardlaw JM, Benveniste H, Nedergaard M, Zlokovic BV, Mestre H, Lee H, Doubal FN, Brown R, Ramirez J, MacIntosh BJ, Tannenbaum A, Ballerini L, Rungta RL, Boido D, Sweeney M, Montagne A, Charpak S, Joutel A, Smith KJ, Black SE. PMID: 32094487.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    4. APOE4 Accelerates Development of Dementia After Stroke: Is There a Role for Cerebrovascular Dysfunction? Stroke. 2020 03; 51(3):699-700. Montagne A, Nation DA, Zlokovic BV. PMID: 32070225.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    5. Proceedings from the Albert Charitable Trust Inaugural Workshop on white matter and cognition in aging. Geroscience. 2020 02; 42(1):81-96. Sorond FA, Whitehead S, Arai K, Arnold D, Carmichael ST, De Carli C, Duering M, Fornage M, Flores-Obando RE, Graff-Radford J, Hamel E, Hess DC, Ihara M, Jensen MK, Markus HS, Montagne A, Rosenberg G, Shih AY, Smith EE, Thiel A, Tse KH, Wilcock D, Barone F. PMID: 31811528.
      View in: PubMed   Mentions:    Fields:    
    6. Undetectable gadolinium brain retention in individuals with an age-dependent blood-brain barrier breakdown in the hippocampus and mild cognitive impairment. Alzheimers Dement. 2019 12; 15(12):1568-1575. Montagne A, Huuskonen MT, Rajagopal G, Sweeney MD, Nation DA, Sepehrband F, D'Orazio LM, Harrington MG, Chui HC, Law M, Toga AW, Zlokovic BV. PMID: 31862169.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss. Nat Neurosci. 2019 07; 22(7):1089-1098. Nikolakopoulou AM, Montagne A, Kisler K, Dai Z, Wang Y, Huuskonen MT, Sagare AP, Lazic D, Sweeney MD, Kong P, Wang M, Owens NC, Lawson EJ, Xie X, Zhao Z, Zlokovic BV. PMID: 31235908.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    8. Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction. Nat Med. 2019 02; 25(2):270-276. Nation DA, Sweeney MD, Montagne A, Sagare AP, D'Orazio LM, Pachicano M, Sepehrband F, Nelson AR, Buennagel DP, Harrington MG, Benzinger TLS, Fagan AM, Ringman JM, Schneider LS, Morris JC, Chui HC, Law M, Toga AW, Zlokovic BV. PMID: 30643288.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
    9. Blood-Brain Barrier: From Physiology to Disease and Back. Physiol Rev. 2019 01 01; 99(1):21-78. Sweeney MD, Zhao Z, Montagne A, Nelson AR, Zlokovic BV. PMID: 30280653.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    10. Vascular dysfunction-The disregarded partner of Alzheimer's disease. Alzheimers Dement. 2019 01; 15(1):158-167. Sweeney MD, Montagne A, Sagare AP, Nation DA, Schneider LS, Chui HC, Harrington MG, Pa J, Law M, Wang DJJ, Jacobs RE, Doubal FN, Ramirez J, Black SE, Nedergaard M, Benveniste H, Dichgans M, Iadecola C, Love S, Bath PM, Markus HS, Salman RA, Allan SM, Quinn TJ, Kalaria RN, Werring DJ, Carare RO, Touyz RM, Williams SCR, Moskowitz MA, Katusic ZS, Lutz SE, Lazarov O, Minshall RD, Rehman J, Davis TP, Wellington CL, González HM, Yuan C, Lockhart SN, Hughes TM, Chen CLH, Sachdev P, O'Brien JT, Skoog I, Pantoni L, Gustafson DR, Biessels GJ, Wallin A, Smith EE, Mok V, Wong A, Passmore P, Barkof F, Muller M, Breteler MMB, Román GC, Hamel E, Seshadri S, Gottesman RF, van Buchem MA, Arvanitakis Z, Schneider JA, Drewes LR, Hachinski V, Finch CE, Toga AW, Wardlaw JM, Zlokovic BV. PMID: 30642436.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    11. The role of brain vasculature in neurodegenerative disorders. Nat Neurosci. 2018 10; 21(10):1318-1331. Sweeney MD, Kisler K, Montagne A, Toga AW, Zlokovic BV. PMID: 30250261.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimals
    12. Permeability imaging as a predictor of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2018 06; 38(6):973-979. Russin JJ, Montagne A, D'Amore F, He S, Shiroishi MS, Rennert RC, Depetris J, Zlokovic BV, Mack WJ. PMID: 29611451.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    13. Pericyte degeneration causes white matter dysfunction in the mouse central nervous system. Nat Med. 2018 03; 24(3):326-337. Montagne A, Nikolakopoulou AM, Zhao Z, Sagare AP, Si G, Lazic D, Barnes SR, Daianu M, Ramanathan A, Go A, Lawson EJ, Wang Y, Mack WJ, Thompson PM, Schneider JA, Varkey J, Langen R, Mullins E, Jacobs RE, Zlokovic BV. PMID: 29400711.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    14. Alzheimer's disease: A matter of blood-brain barrier dysfunction? J Exp Med. 2017 Nov 06; 214(11):3151-3169. Montagne A, Zhao Z, Zlokovic BV. PMID: 29061693.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimals
    15. Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease. Nat Rev Neurosci. 2017 07; 18(7):419-434. Kisler K, Nelson AR, Montagne A, Zlokovic BV. PMID: 28515434.
      View in: PubMed   Mentions: 88     Fields:    Translation:Humans
    16. Regional early and progressive loss of brain pericytes but not vascular smooth muscle cells in adult mice with disrupted platelet-derived growth factor receptor-ß signaling. PLoS One. 2017; 12(4):e0176225. Nikolakopoulou AM, Zhao Z, Montagne A, Zlokovic BV. PMID: 28441414.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    17. Brain imaging of neurovascular dysfunction in Alzheimer's disease. Acta Neuropathol. 2016 May; 131(5):687-707. Montagne A, Nation DA, Pa J, Sweeney MD, Toga AW, Zlokovic BV. PMID: 27038189.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    18. Blood-Brain Barrier Permeability and Gadolinium: Benefits and Potential Pitfalls in Research. JAMA Neurol. 2016 Jan; 73(1):13-4. Montagne A, Toga AW, Zlokovic BV. PMID: 26524294.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    19. Tissue Plasminogen Activator Expression Is Restricted to Subsets of Excitatory Pyramidal Glutamatergic Neurons. Mol Neurobiol. 2016 09; 53(7):5000-12. Louessard M, Lacroix A, Martineau M, Mondielli G, Montagne A, Lesept F, Lambolez B, Cauli B, Mothet JP, Vivien D, Maubert E. PMID: 26377106.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    20. ROCKETSHIP: a flexible and modular software tool for the planning, processing and analysis of dynamic MRI studies. BMC Med Imaging. 2015 Jun 16; 15:19. Barnes SR, Ng TS, Santa-Maria N, Montagne A, Zlokovic BV, Jacobs RE. PMID: 26076957.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    21. Optimal acquisition and modeling parameters for accurate assessment of low Ktrans blood-brain barrier permeability using dynamic contrast-enhanced MRI. Magn Reson Med. 2016 May; 75(5):1967-77. Barnes SR, Ng TS, Montagne A, Law M, Zlokovic BV, Jacobs RE. PMID: 26077645.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    22. Vascular plasticity and cognition during normal aging and dementia. JAMA Neurol. 2015 May; 72(5):495-6. Montagne A, Pa J, Zlokovic BV. PMID: 25751405.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    23. Impact of alcohol consumption on the outcome of ischemic stroke and thrombolysis: role of the hepatic clearance of tissue-type plasminogen activator. Stroke. 2015 Jun; 46(6):1641-50. Lemarchand E, Gauberti M, Martinez de Lizarrondo S, Villain H, Repessé Y, Montagne A, Vivien D, Ali C, Rubio M. PMID: 25922513.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    24. 7T Multi-shell Hybrid Diffusion Imaging (HYDI) for Mapping Brain Connectivity in Mice. Proc SPIE Int Soc Opt Eng. 2015 Mar 20; 9413. Daianu M, Jahanshad N, Villalon-Reina JE, Prasad G, Jacobs RE, Barnes S, Zlokovic BV, Montagne A, Thompson PM. PMID: 25859293.
      View in: PubMed   Mentions:
    25. Blood-brain barrier breakdown in the aging human hippocampus. Neuron. 2015 Jan 21; 85(2):296-302. Montagne A, Barnes SR, Sweeney MD, Halliday MR, Sagare AP, Zhao Z, Toga AW, Jacobs RE, Liu CY, Amezcua L, Harrington MG, Chui HC, Law M, Zlokovic BV. PMID: 25611508.
      View in: PubMed   Mentions: 311     Fields:    Translation:HumansCells
    26. Molecular magnetic resonance imaging of brain-immune interactions. Front Cell Neurosci. 2014; 8:389. Gauberti M, Montagne A, Quenault A, Vivien D. PMID: 25505871.
      View in: PubMed   Mentions:
    27. Urokinase versus Alteplase for intraventricular hemorrhage fibrinolysis. Neuropharmacology. 2014 Oct; 85:158-65. Gaberel T, Montagne A, Lesept F, Gauberti M, Lemarchand E, Orset C, Goulay R, Bertrand T, Emery E, Vivien D. PMID: 24846802.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    28. GpIba-VWF blockade restores vessel patency by dissolving platelet aggregates formed under very high shear rate in mice. Blood. 2014 May 22; 123(21):3354-63. Le Behot A, Gauberti M, Martinez De Lizarrondo S, Montagne A, Lemarchand E, Repesse Y, Guillou S, Denis CV, Maubert E, Orset C, Vivien D. PMID: 24553181.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    29. Intracerebral hematomas disappear on T2*-weighted images during normobaric oxygen therapy. Stroke. 2013 Dec; 44(12):3482-9. Gaberel T, Gakuba C, Hebert M, Montagne A, Agin V, Rubio M, Emery E, Vivien D, Gauberti M. PMID: 24105700.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    30. Ultra-sensitive molecular MRI of vascular cell adhesion molecule-1 reveals a dynamic inflammatory penumbra after strokes. Stroke. 2013 Jul; 44(7):1988-96. Gauberti M, Montagne A, Marcos-Contreras OA, Le Béhot A, Maubert E, Vivien D. PMID: 23743972.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    31. Immunotherapy blocking the tissue plasminogen activator-dependent activation of N-methyl-D-aspartate glutamate receptors improves hemorrhagic stroke outcome. Neuropharmacology. 2013 Apr; 67:267-71. Gaberel T, Macrez R, Gauberti M, Montagne A, Hebert M, Petersen KU, Touze E, Agin V, Emery E, Ali C, Vivien D. PMID: 23219658.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    32. Memantine improves safety of thrombolysis for stroke. Stroke. 2012 Oct; 43(10):2774-81. Montagne A, Hébert M, Jullienne A, Lesept F, Le Béhot A, Louessard M, Gauberti M, Orset C, Ali C, Agin V, Maubert E, Vivien D. PMID: 22879098.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    33. Ultra-sensitive molecular MRI of cerebrovascular cell activation enables early detection of chronic central nervous system disorders. Neuroimage. 2012 Nov 01; 63(2):760-70. Montagne A, Gauberti M, Macrez R, Jullienne A, Briens A, Raynaud JS, Louin G, Buisson A, Haelewyn B, Docagne F, Defer G, Vivien D, Maubert E. PMID: 22813950.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    34. Unveiling an exceptional zymogen: the single-chain form of tPA is a selective activator of NMDA receptor-dependent signaling and neurotoxicity. Cell Death Differ. 2012 Dec; 19(12):1983-91. Parcq J, Bertrand T, Montagne A, Baron AF, Macrez R, Billard JM, Briens A, Hommet Y, Wu J, Yepes M, Lijnen HR, Dutar P, Anglés-Cano E, Vivien D. PMID: 22743997.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    35. Glutamate controls tPA recycling by astrocytes, which in turn influences glutamatergic signals. J Neurosci. 2012 Apr 11; 32(15):5186-99. Cassé F, Bardou I, Danglot L, Briens A, Montagne A, Parcq J, Alahari A, Galli T, Vivien D, Docagne F. PMID: 22496564.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    36. Selective inhibition of GluN2D-containing N-methyl-D-aspartate receptors prevents tissue plasminogen activator-promoted neurotoxicity both in vitro and in vivo. Mol Neurodegener. 2011 Oct 05; 6:68. Jullienne A, Montagne A, Orset C, Lesept F, Jane DE, Monaghan DT, Maubert E, Vivien D, Ali C. PMID: 21975018.
      View in: PubMed   Mentions: 7     Fields:    
    37. Impact of tissue plasminogen activator on the neurovascular unit: from clinical data to experimental evidence. J Cereb Blood Flow Metab. 2011 Nov; 31(11):2119-34. Vivien D, Gauberti M, Montagne A, Defer G, Touzé E. PMID: 21878948.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    38. Tissue plasminogen activator prevents white matter damage following stroke. J Exp Med. 2011 Jun 06; 208(6):1229-42. Correa F, Gauberti M, Parcq J, Macrez R, Hommet Y, Obiang P, Hernangómez M, Montagne A, Liot G, Guaza C, Maubert E, Ali C, Vivien D, Docagne F. PMID: 21576385.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    39. NR2D-containing NMDA receptors mediate tissue plasminogen activator-promoted neuronal excitotoxicity. Cell Death Differ. 2010 May; 17(5):860-71. Baron A, Montagne A, Cassé F, Launay S, Maubert E, Ali C, Vivien D. PMID: 19911010.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
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