Loading...

Mariangela Nikolakopoulou, PhD

Title(s)Assistant Professor of Research Physiology and Neuroscience
AddressZNI 301,1501 San Pablo Street
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 0216
vCardDownload vCard

    Collapse Overview 
    Collapse Overview
    I’m particularly interested in research associated with neurodegenerative diseases Early in my scientific career, I focused my research on Multiple Sclerosis and I used in vitro models to investigate factors that may enhance neurogenesis in white matter lesions. I discovered through my studies that trypsinogen, a serine protease, is an activated-microglia secreted factor that increases neurogenesis. Later in my career I applied my previous findings to discover neuroprotective agents against toxicity in Alzheimer Disease.
    Currently, my studies focus on blood brain barrier (BBB) damage and vascular-related neurodegeneration. In particular, I am studying pericyte deficiency in relation to demyelination, while my recent studies focus on selective ablation of pericytes in adulthood causing BBB leakage and distortion of capillary density. In addition, I am studying the effects of endothelial LRP1 depletion and am showing that short and long-term treatment with Cyclosporine A can reverse BBB leakage and neurodegeneration respectively.
    Over the years I have been successful in obtaining extramural funding from the Multiple Sclerosis society (NMMS) to study the effects of astrocytic ephrinB1 in demyelination and remyelination.
    Some of the techniques I apply for my studies include cell culture, western blotting, immunoprecipitation, flow cytometry, immunohistochemistry/immunofluorescence, immunocytochemistry, electron microscopy pre-embedding immunohistochemistry, cell transfection, viral infections, intracranial injections, microvessel isolation, CSF extraction, and reverse transcriptase chain polymerase reaction.

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Acute Ablation of Cortical Pericytes Leads to Rapid Neurovascular Uncoupling. Front Cell Neurosci. 2020; 14:27. Kisler K, Nikolakopoulou AM, Sweeney MD, Lazic D, Zhao Z, Zlokovic BV. PMID: 32116568.
      View in: PubMed   Mentions:
    2. Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss. Nat Neurosci. 2019 07; 22(7):1089-1098. Nikolakopoulou AM, Montagne A, Kisler K, Dai Z, Wang Y, Huuskonen MT, Sagare AP, Lazic D, Sweeney MD, Kong P, Wang M, Owens NC, Lawson EJ, Xie X, Zhao Z, Zlokovic BV. PMID: 31235908.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    3. 3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice. J Exp Med. 2019 02 04; 216(2):279-293. Lazic D, Sagare AP, Nikolakopoulou AM, Griffin JH, Vassar R, Zlokovic BV. PMID: 30647119.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    4. Functional Consequences of Synapse Remodeling Following Astrocyte-Specific Regulation of Ephrin-B1 in the Adult Hippocampus. J Neurosci. 2018 06 20; 38(25):5710-5726. Koeppen J, Nguyen AQ, Nikolakopoulou AM, Garcia M, Hanna S, Woodruff S, Figueroa Z, Obenaus A, Ethell IM. PMID: 29793972.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    5. Pericyte degeneration causes white matter dysfunction in the mouse central nervous system. Nat Med. 2018 03; 24(3):326-337. Montagne A, Nikolakopoulou AM, Zhao Z, Sagare AP, Si G, Lazic D, Barnes SR, Daianu M, Ramanathan A, Go A, Lawson EJ, Wang Y, Mack WJ, Thompson PM, Schneider JA, Varkey J, Langen R, Mullins E, Jacobs RE, Zlokovic BV. PMID: 29400711.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    6. Role of Neuropilin-1/Semaphorin-3A signaling in the functional and morphological integrity of the cochlea. PLoS Genet. 2017 Oct; 13(10):e1007048. Salehi P, Ge MX, Gundimeda U, Michelle Baum L, Lael Cantu H, Lavinsky J, Tao L, Myint A, Cruz C, Wang J, Nikolakopoulou AM, Abdala C, Kelley MW, Ohyama T, Coate TM, Friedman RA. PMID: 29059194.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    7. Regional early and progressive loss of brain pericytes but not vascular smooth muscle cells in adult mice with disrupted platelet-derived growth factor receptor-ß signaling. PLoS One. 2017; 12(4):e0176225. Nikolakopoulou AM, Zhao Z, Montagne A, Zlokovic BV. PMID: 28441414.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    8. Presenilin 1 promotes trypsin-induced neuroprotection via the PAR2/ERK signaling pathway. Effects of presenilin 1 FAD mutations. Neurobiol Aging. 2016 06; 42:41-9. Nikolakopoulou AM, Georgakopoulos A, Robakis NK. PMID: 27143420.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    9. Astrocytic Ephrin-B1 Regulates Synapse Remodeling Following Traumatic Brain Injury. ASN Neuro. 2016 Jan-Feb; 8(1):1-18. Nikolakopoulou AM, Koeppen J, Garcia M, Leish J, Obenaus A, Ethell IM. PMID: 26928051.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    10. Activated microglia enhance neurogenesis via trypsinogen secretion. Proc Natl Acad Sci U S A. 2013 May 21; 110(21):8714-9. Nikolakopoulou AM, Dutta R, Chen Z, Miller RH, Trapp BD. PMID: 23650361.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    11. Synaptic maturation of the Xenopus retinotectal system: effects of brain-derived neurotrophic factor on synapse ultrastructure. J Comp Neurol. 2010 Apr 01; 518(7):972-89. Nikolakopoulou AM, Meynard MM, Marshak S, Cohen-Cory S. PMID: 20127801.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    12. Netrin participates in the development of retinotectal synaptic connectivity by modulating axon arborization and synapse formation in the developing brain. J Neurosci. 2009 Sep 09; 29(36):11065-77. Manitt C, Nikolakopoulou AM, Almario DR, Nguyen SA, Cohen-Cory S. PMID: 19741113.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    13. Cell-autonomous TrkB signaling in presynaptic retinal ganglion cells mediates axon arbor growth and synapse maturation during the establishment of retinotectal synaptic connectivity. J Neurosci. 2007 Mar 07; 27(10):2444-56. Marshak S, Nikolakopoulou AM, Dirks R, Martens GJ, Cohen-Cory S. PMID: 17344382.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    14. Passive avoidance training is correlated with decreased cell proliferation in the chick hippocampus. Eur J Neurosci. 2006 Nov; 24(9):2631-42. Nikolakopoulou AM, Dermon CR, Panagis L, Pavlidis M, Stewart MG. PMID: 17100851.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    15. Early post-hatching sex differences in cell proliferation and survival in the quail telencephalic ventricular zone and intermediate medial mesopallium. Brain Res Bull. 2006 Jun 30; 70(2):107-16. Nikolakopoulou AM, Parpas A, Panagis L, Zikopoulos B, Dermon CR. PMID: 16782501.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    16. Passive avoidance training decreases synapse density in the hippocampus of the domestic chick. Eur J Neurosci. 2006 Feb; 23(4):1054-62. Nikolakopoulou AM, Davies HA, Stewart MG. PMID: 16519670.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    17. BDNF stabilizes synapses and maintains the structural complexity of optic axons in vivo. Development. 2005 Oct; 132(19):4285-98. Hu B, Nikolakopoulou AM, Cohen-Cory S. PMID: 16141221.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    Angeliki's Networks
    Concepts (119)
    Derived automatically from this person's publications.
    _
    Co-Authors (17)
    People in Profiles who have published with this person.
    _
    Similar People (60)
    People who share similar concepts with this person.
    _
    Same Department
    Search Department
    _