Andrew P. McMahon, PhD

Title(s)W.M. Keck Provost and University Professor of Stem Cell Biology and Regenerative Medicine, Biological Sciences and Quantitative and Computational Biology
SchoolKeck School of Medicine of Usc
AddressBCC 312 1425 San Pablo Street
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 3056
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    Other Positions
    Title(s)Chair of Stem Cell Biology and Regenerative Medicine

    Title(s)Director, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC


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    Professor Andrew (Andy) McMahon is the Chair of the Department of Stem Cell Biology and Regenerative Medicine and Director of the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at the Keck School of Medicine of the University of Southern California (USC). McMahon joined USC from Harvard University in 2012 as the W.M. Keck Provost Professor of Stem Cell Biology and Regenerative Medicine, and Biological Sciences, and founding chair of the Department of Stem Cell Biology and Regenerative Medicine.

    McMahon is a leader in the field of developmental biology. McMahon’s research has provided fundamental insights into the cell interactions driving assembly of multiple organ systems, including the central nervous system, skeleton and kidney. McMahon’s research has identified diverse mechanisms regulating organ development, tissue repair and cancer. Current research focuses on development, injury and repair of the mammalian kidney, to model and treat kidney disease.

    McMahon received his bachelor's degree from Oxford University and his PhD from University College London. McMahon completed his postdoctoral research at the California Institute of Technology, then moved to London to start his independent research laboratory in 1984. In 1988, McMahon took up a position as assistant member at the Roche Institute for Molecular Biology, becoming full member and chair of the department in 1992. In 1993, McMahon became a professor of Molecular and Cellular Biology in the Faculty of Arts and Sciences at Harvard University. In a 19-year career at Harvard, McMahon was the Frank B. Baird Jr., Professor of Science, chair of the Department of Cell and Developmental Biology, a founding faculty of the Department of Stem Cells and Regenerative Biology, and principal investigator of the Harvard Stem Cell Institute.

    McMahon is an elected fellow of the National Academy of Sciences, the American Association for the Advancement of Science, the American Academy of Arts and Sciences, the European Molecular Biology Organization and the Royal Society.

    Collapse Research 
    Collapse Research Activities and Funding
    Sexual dimorphism in the mammalian kidney
    NIH R01DK126925Sep 17, 2020 - May 31, 2025
    Role: Principal Investigator
    Single-cell analysis to promote kidney repair
    NIH UC2DK126024Sep 1, 2020 - May 31, 2025
    Role: Co-Principal Investigator
    Mapping protein communication between organs in homeostasis and disease
    NIH R01DK121409Sep 25, 2018 - Jun 30, 2023
    Role: Co-Principal Investigator
    Epigenetic mechanisms underlying the failure of hair cell regeneration in mammals
    NIH R01DC015829Jul 1, 2018 - Jun 30, 2023
    Role: Co-Principal Investigator
    Establishing Mechanisms of Human Proximal Tubule Regeneration in an Engineered Organ on Chip Platform
    NIH R21EB025534Sep 23, 2017 - Jul 31, 2021
    Role: Co-Principal Investigator
    Four-dimensional Modeling of Mouse and Human Nephrogenesis.
    NIH U01DK110792Sep 15, 2016 - May 31, 2021
    Role: Principal Investigator
    Lineage reprogramming for hearing loss: development of drug screening and gene therapy approaches
    NIH R01DC015530Jul 1, 2016 - Jun 30, 2021
    Role: Co-Principal Investigator
    The USC (Re)Building the Kidney Coordinating Center
    NIH U01DK107350Sep 23, 2015 - Aug 31, 2021
    Role: Co-Principal Investigator
    GUDMAP2 - Production of Mouse Strains for Gene Anatomy of the Lower Urinary Tract
    NIH U01DK094526Sep 30, 2011 - Mar 31, 2017
    Role: Principal Investigator
    Kidney molecular atlas project
    NIH U01DK070181Sep 30, 2004 - Jul 31, 2012
    Role: Principal Investigator
    Developmental Regulation of Bone Morphogenesis
    NIH P01DK056246Aug 20, 1999 - May 31, 2016
    Role: Co-Principal Investigator
    Cell Interactions in Development of the Mammalian Kidney
    NIH R01DK054364Sep 1, 1998 - Dec 31, 2022
    Role: Principal Investigator
    Cell Interactions in Development of the Mammalian Kidney
    NIH R37DK054364Sep 1, 1998 - Jan 14, 2019
    Role: Principal Investigator
    CONFERENCE ON VERTEBRATE DEVELOPMENT
    NIH R13HD036196Mar 1, 1998 - Feb 28, 1999
    Role: Principal Investigator
    Regulation of polarity by Sonic hedgehog morphogen signaling
    NIH R01NS033642Dec 1, 1994 - Jul 31, 2018
    Role: Principal Investigator
    Regulation of CNS and Limb Polarity by Sonic Hedgehog
    NIH R37NS033642Dec 1, 1994 - Sep 14, 2012
    Role: Principal Investigator
    ACTIVATION OF A PATTERNING SIGNAL IN THE CNS
    NIH R01NS032691Apr 1, 1994 - Mar 31, 1998
    Role: Principal Investigator
    PATTERN REGULATION IN THE VERTEBRATE CNS
    NIH R01HD030249Dec 1, 1993 - Nov 30, 2003
    Role: Principal Investigator

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    Collapse Required Scholarly Project Mentor

    Collapse Featured Content 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Comparative single-cell analyses identify shared and divergent features of human and mouse kidney development. Dev Cell. 2024 Aug 07. Kim S, Koppitch K, Parvez RK, Guo J, Achieng M, Schnell J, Lindström NO, McMahon AP. PMID: 39121855.
      View in: PubMed   Mentions:
    2. Molecular motor tug-of-war regulates elongasome cell wall synthesis dynamics in Bacillus subtilis. Nat Commun. 2024 Jun 26; 15(1):5411. Middlemiss S, Blandenet M, Roberts DM, McMahon A, Grimshaw J, Edwards JM, Sun Z, Whitley KD, Blu T, Strahl H, Holden S. PMID: 38926336; PMCID: PMC11208587.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    3. Long-term expandable mouse and human-induced nephron progenitor cells enable kidney organoid maturation and modeling of plasticity and disease. Cell Stem Cell. 2024 Jun 06; 31(6):921-939.e17. Huang B, Zeng Z, Kim S, Fausto CC, Koppitch K, Li H, Li Z, Chen X, Guo J, Zhang CC, Ma T, Medina P, Schreiber ME, Xia MW, Vonk AC, Xiang T, Patel T, Li Y, Parvez RK, Der B, Chen JH, Liu Z, Thornton ME, Grubbs BH, Diao Y, Dou Y, Gnedeva K, Ying Q, Pastor-Soler NM, Fei T, Hallows KR, Lindström NO, McMahon AP, Li Z. PMID: 38692273; PMCID: PMC11162329.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Spatial transcriptomics defines injury-specific microenvironments in the adult mouse kidney and novel cellular interactions in regeneration and disease. bioRxiv. 2023 Nov 22. Polonsky M, Gerhardt LMS, Yun J, Koppitch K, Colón KL, Amrhein H, Zheng S, Yuan GC, Thomson M, Cai L, McMahon AP. PMID: 38045285; PMCID: PMC10690238.
      View in: PubMed   Mentions:
    5. Direct androgen receptor control of sexually dimorphic gene expression in the mammalian kidney. Dev Cell. 2023 11 06; 58(21):2338-2358.e5. Xiong L, Liu J, Han SY, Koppitch K, Guo JJ, Rommelfanger M, Miao Z, Gao F, Hallgrimsdottir IB, Pachter L, Kim J, MacLean AL, McMahon AP. PMID: 37673062; PMCID: PMC10873092.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    6. Cadherin Adhesion Complexes Direct Cell Aggregation in the Epithelial Transition of Wnt-Induced Nephron Progenitor Cells. bioRxiv. 2023 Aug 27. Der B, Bugacov H, Briantseva BM, McMahon AP. PMID: 38654822; PMCID: PMC11037868.
      View in: PubMed   Mentions:
    7. Canonical Wnt transcriptional complexes are essential for induction of nephrogenesis but not maintenance or proliferation of nephron progenitors. bioRxiv. 2023 Aug 21. Bugacov H, Der B, Kim S, Lindström NO, McMahon AP. PMID: 37662369; PMCID: PMC10473675.
      View in: PubMed   Mentions:
    8. User-friendly microfluidic system reveals native-like morphological and transcriptomic phenotypes induced by shear stress in proximal tubule epithelium. APL Bioeng. 2023 Sep; 7(3):036106. Khalil NN, Petersen AP, Song CJ, Chen Y, Takamoto K, Kellogg AC, Chen EZ, McMahon AP, McCain ML. PMID: 37584027; PMCID: PMC10424157.
      View in: PubMed   Mentions: 1  
    9. Modeling kidney development, disease, and plasticity with clonal expandable nephron progenitor cells and nephron organoids. bioRxiv. 2023 May 25. Huang B, Zeng Z, Li H, Li Z, Chen X, Guo J, Zhang CC, Schreiber ME, Vonk AC, Xiang T, Patel T, Li Y, Parvez RK, Der B, Chen JH, Liu Z, Thornton ME, Grubbs BH, Diao Y, Dou Y, Gnedeva K, Lindström NO, Ying Q, Pastor-Soler NM, Fei T, Hallows KR, McMahon AP, Li Z. PMID: 37293038; PMCID: PMC10245960.
      View in: PubMed   Mentions:
    10. Direct androgen receptor regulation of sexually dimorphic gene expression in the mammalian kidney. bioRxiv. 2023 May 25. Xiong L, Liu J, Han SY, Koppitch K, Guo JJ, Rommelfanger M, Gao F, Hallgrimsdottir IB, Pachter L, Kim J, MacLean AL, McMahon AP. PMID: 37205355; PMCID: PMC10187285.
      View in: PubMed   Mentions:
    11. Comparative single-cell analyses identify shared and divergent features of human and mouse kidney development. bioRxiv. 2023 May 17. Kim S, Koppitch K, Parvez RK, Guo J, Achieng M, Schnell J, Lindström NO, McMahon AP. PMID: 37293066; PMCID: PMC10245679.
      View in: PubMed   Mentions:
    12. Proximal tubule responses to injury: interrogation by single-cell transcriptomics. Curr Opin Nephrol Hypertens. 2023 07 01; 32(4):352-358. Cippà PE, McMahon AP. PMID: 37074682; PMCID: PMC10330172.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    13. Lineage Tracing and Single-Nucleus Multiomics Reveal Novel Features of Adaptive and Maladaptive Repair after Acute Kidney Injury. J Am Soc Nephrol. 2023 04 01; 34(4):554-571. Gerhardt LMS, Koppitch K, van Gestel J, Guo J, Cho S, Wu H, Kirita Y, Humphreys BD, McMahon AP. PMID: 36735940; PMCID: PMC10103206.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    14. Identifying Common Molecular Mechanisms in Experimental and Human Acute Kidney Injury. Semin Nephrol. 2022 05; 42(3):151286. Gerhardt LMS, McMahon AP. PMID: 36402654; PMCID: PMC11017289.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    15. Runx2 regulates chromatin accessibility to direct the osteoblast program at neonatal stages. Cell Rep. 2022 09 06; 40(10):111315. Hojo H, Saito T, He X, Guo Q, Onodera S, Azuma T, Koebis M, Nakao K, Aiba A, Seki M, Suzuki Y, Okada H, Tanaka S, Chung UI, McMahon AP, Ohba S. PMID: 36070691; PMCID: PMC9510047.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    16. A genetic model for in vivo proximity labelling of the mammalian secretome. Open Biol. 2022 08; 12(8):220149. Yang R, Meyer AS, Droujinine IA, Udeshi ND, Hu Y, Guo J, McMahon JA, Carey DK, Xu C, Fang Q, Sha J, Qin S, Rocco D, Wohlschlegel J, Ting AY, Carr SA, Perrimon N, McMahon AP. PMID: 35946312; PMCID: PMC9364151.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    17. A scalable organoid model of human autosomal dominant polycystic kidney disease for disease mechanism and drug discovery. Cell Stem Cell. 2022 07 07; 29(7):1083-1101.e7. Tran T, Song CJ, Nguyen T, Cheng SY, McMahon JA, Yang R, Guo Q, Der B, Lindström NO, Lin DC, McMahon AP. PMID: 35803227; PMCID: PMC11088748.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    18. Transcriptional and functional motifs defining renal function revealed by single-nucleus RNA sequencing. Proc Natl Acad Sci U S A. 2022 06 21; 119(25):e2203179119. Xu J, Liu Y, Li H, Tarashansky AJ, Kalicki CH, Hung RJ, Hu Y, Comjean A, Kolluru SS, Wang B, Quake SR, Luo L, McMahon AP, Dow JAT, Perrimon N. PMID: 35696569; PMCID: PMC9231607.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    19. Kidney repair and regeneration: perspectives of the NIDDK (Re)Building a Kidney consortium. Kidney Int. 2022 05; 101(5):845-853. Naved BA, Bonventre JV, Hubbell JA, Hukriede NA, Humphreys BD, Kesselman C, Valerius MT, McMahon AP, Shankland SJ, Wertheim JA, White MJV, de Caestecker MP, Drummond IA. PMID: 35276204; PMCID: PMC9045003.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    20. Repairing the blood-brain barrier. Science. 2022 02 18; 375(6582):715-716. McMahon AP, Ichida JK. PMID: 35175806.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    21. Multi-omic approaches to acute kidney injury and repair. Curr Opin Biomed Eng. 2021 Dec; 20. Gerhardt LMS, McMahon AP. PMID: 35005326; PMCID: PMC8740908.
      View in: PubMed   Mentions: 6  
    22. Spatial transcriptional mapping of the human nephrogenic program. Dev Cell. 2021 08 23; 56(16):2381-2398.e6. Lindström NO, Sealfon R, Chen X, Parvez RK, Ransick A, De Sena Brandine G, Guo J, Hill B, Tran T, Kim AD, Zhou J, Tadych A, Watters A, Wong A, Lovero E, Grubbs BH, Thornton ME, McMahon JA, Smith AD, Ruffins SW, Armit C, Troyanskaya OG, McMahon AP. PMID: 34428401; PMCID: PMC8396064.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    23. Multi-omics integration in the age of million single-cell data. Nat Rev Nephrol. 2021 11; 17(11):710-724. Miao Z, Humphreys BD, McMahon AP, Kim J. PMID: 34417589; PMCID: PMC9191639.
      View in: PubMed   Mentions: 56     Fields:    Translation:Humans
    24. Single-nuclear transcriptomics reveals diversity of proximal tubule cell states in a dynamic response to acute kidney injury. Proc Natl Acad Sci U S A. 2021 07 06; 118(27). Gerhardt LMS, Liu J, Koppitch K, Cippà PE, McMahon AP. PMID: 34183416; PMCID: PMC8271768.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    25. Generation of patterned kidney organoids that recapitulate the adult kidney collecting duct system from expandable ureteric bud progenitors. Nat Commun. 2021 06 15; 12(1):3641. Zeng Z, Huang B, Parvez RK, Li Y, Chen J, Vonk AC, Thornton ME, Patel T, Rutledge EA, Kim AD, Yu J, Grubbs BH, McMahon JA, Pastor-Soler NM, Hallows KR, McMahon AP, Li Z. PMID: 34131121; PMCID: PMC8206157.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    26. Correction: A β-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells. Elife. 2021 Apr 29; 10. Guo Q, Kim AD, Li B, Ransick A, Bugacov H, Chen X, Lindström NO, Brown A, Oxburgh L, Ren B, McMahon AP. PMID: 33913807; PMCID: PMC8084526.
      View in: PubMed   Mentions:    Fields:    
    27. Proteomics of protein trafficking by in vivo tissue-specific labeling. Nat Commun. 2021 04 22; 12(1):2382. Droujinine IA, Meyer AS, Wang D, Udeshi ND, Hu Y, Rocco D, McMahon JA, Yang R, Guo J, Mu L, Carey DK, Svinkina T, Zeng R, Branon T, Tabatabai A, Bosch JA, Asara JM, Ting AY, Carr SA, McMahon AP, Perrimon N. PMID: 33888706; PMCID: PMC8062696.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    28. A β-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells. Elife. 2021 02 15; 10. Guo Q, Kim A, Li B, Ransick A, Bugacov H, Chen X, Lindström N, Brown A, Oxburgh L, Ren B, McMahon AP. PMID: 33587034; PMCID: PMC7924951.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    29. Author Correction: Altered proximal tubular cell glucose metabolism during acute kidney injury is associated with mortality. Nat Metab. 2020 09; 2(9):989. Legouis D, Ricksten SE, Faivre A, Verissimo T, Gariani K, Verney C, Galichon P, Berchtold L, Feraille E, Fernandez M, Placier S, Koppitch K, Hertig A, Martin PY, Naesens M, Pugin J, McMahon AP, Cippà PE, de Seigneux S. PMID: 32873966.
      View in: PubMed   Mentions: 1     Fields:    
    30. Altered proximal tubular cell glucose metabolism during acute kidney injury is associated with mortality. Nat Metab. 2020 08; 2(8):732-743. Legouis D, Ricksten SE, Faivre A, Verissimo T, Gariani K, Verney C, Galichon P, Berchtold L, Feraille E, Fernandez M, Placier S, Koppitch K, Hertig A, Martin PY, Naesens M, Pugin J, McMahon AP, Cippà PE, de Seigneux S. PMID: 32694833.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    31. A novel distal convoluted tubule-specific Cre-recombinase driven by the NaCl cotransporter gene. Am J Physiol Renal Physiol. 2020 09 01; 319(3):F423-F435. Cornelius RJ, Sharma A, Su XT, Guo JJ, McMahon JA, Ellison DH, McMahon AP, McCormick JA. PMID: 32657158; PMCID: PMC7509282.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    32. Mutational analysis of genes with ureteric progenitor cell-specific expression in branching morphogenesis of the mouse kidney. Dev Dyn. 2020 06; 249(6):765-774. Rutledge EA, McMahon AP. PMID: 32017326; PMCID: PMC7679181.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    33. Renoprotective and Immunomodulatory Effects of GDF15 following AKI Invoked by Ischemia-Reperfusion Injury. J Am Soc Nephrol. 2020 04; 31(4):701-715. Liu J, Kumar S, Heinzel A, Gao M, Guo J, Alvarado GF, Reindl-Schwaighofer R, Krautzberger AM, Cippà PE, McMahon J, Oberbauer R, McMahon AP. PMID: 32034106; PMCID: PMC7191932.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    34. Genetic manipulation of ureteric bud tip progenitors in the mammalian kidney through an Adamts18 enhancer driven tet-on inducible system. Dev Biol. 2020 02 15; 458(2):164-176. Rutledge EA, Lindström NO, Michos O, McMahon AP. PMID: 31734175; PMCID: PMC6995766.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    35. Single-Cell Profiling Reveals Sex, Lineage, and Regional Diversity in the Mouse Kidney. Dev Cell. 2019 11 04; 51(3):399-413.e7. Ransick A, Lindström NO, Liu J, Zhu Q, Guo JJ, Alvarado GF, Kim AD, Black HG, Kim J, McMahon AP. PMID: 31689386; PMCID: PMC6948019.
      View in: PubMed   Mentions: 154     Fields:    Translation:AnimalsCells
    36. Cellular Recruitment by Podocyte-Derived Pro-migratory Factors in Assembly of the Human Renal Filter. iScience. 2019 Oct 25; 20:402-414. Kim AD, Lake BB, Chen S, Wu Y, Guo J, Parvez RK, Tran T, Thornton ME, Grubbs B, McMahon JA, Zhang K, McMahon AP. PMID: 31622881; PMCID: PMC6817668.
      View in: PubMed   Mentions: 6  
    37. In Vivo Developmental Trajectories of Human Podocyte Inform In Vitro Differentiation of Pluripotent Stem Cell-Derived Podocytes. Dev Cell. 2019 07 01; 50(1):102-116.e6. Tran T, Lindström NO, Ransick A, De Sena Brandine G, Guo Q, Kim AD, Der B, Peti-Peterdi J, Smith AD, Thornton M, Grubbs B, McMahon JA, McMahon AP. PMID: 31265809; PMCID: PMC6684316.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    38. Morphogenesis of the kidney and lung requires branch-tip directed activity of the Adamts18 metalloprotease. Dev Biol. 2019 10 15; 454(2):156-169. Rutledge EA, Parvez RK, Short KM, Smyth IM, McMahon AP. PMID: 31242448; PMCID: PMC6726516.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    39. A late B lymphocyte action in dysfunctional tissue repair following kidney injury and transplantation. Nat Commun. 2019 03 11; 10(1):1157. Cippà PE, Liu J, Sun B, Kumar S, Naesens M, McMahon AP. PMID: 30858375; PMCID: PMC6411919.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    40. Image-based modeling of kidney branching morphogenesis reveals GDNF-RET based Turing-type mechanism and pattern-modulating WNT11 feedback. Nat Commun. 2019 01 16; 10(1):239. Menshykau D, Michos O, Lang C, Conrad L, McMahon AP, Iber D. PMID: 30651543; PMCID: PMC6484223.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    41. Wnt11 directs nephron progenitor polarity and motile behavior ultimately determining nephron endowment. Elife. 2018 12 05; 7. O'Brien LL, Combes AN, Short KM, Lindström NO, Whitney PH, Cullen-McEwen LA, Ju A, Abdelhalim A, Michos O, Bertram JF, Smyth IM, Little MH, McMahon AP. PMID: 30516471; PMCID: PMC6281319.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    42. Transcriptional trajectories of human kidney injury progression. JCI Insight. 2018 11 15; 3(22). Cippà PE, Sun B, Liu J, Chen L, Naesens M, McMahon AP. PMID: 30429361; PMCID: PMC6302941.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    43. Single-Cell RNA Sequencing of the Adult Mouse Kidney: From Molecular Cataloging of Cell Types to Disease-Associated Predictions. Am J Kidney Dis. 2019 01; 73(1):140-142. Lindström NO, De Sena Brandine G, Ransick A, McMahon AP. PMID: 30241960; PMCID: PMC6480390.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    44. Gli3 controls the onset of cortical neurogenesis by regulating the radial glial cell cycle through Cdk6 expression. Development. 2018 08 20; 145(17). Hasenpusch-Theil K, West S, Kelman A, Kozic Z, Horrocks S, McMahon AP, Price DJ, Mason JO, Theil T. PMID: 30093555; PMCID: PMC6141774.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    45. A Simple Bioreactor-Based Method to Generate Kidney Organoids from Pluripotent Stem Cells. Stem Cell Reports. 2018 08 14; 11(2):470-484. Przepiorski A, Sander V, Tran T, Hollywood JA, Sorrenson B, Shih JH, Wolvetang EJ, McMahon AP, Holm TM, Davidson AJ. PMID: 30033089; PMCID: PMC6092837.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansCells
    46. Progressive Recruitment of Mesenchymal Progenitors Reveals a Time-Dependent Process of Cell Fate Acquisition in Mouse and Human Nephrogenesis. Dev Cell. 2018 06 04; 45(5):651-660.e4. Lindström NO, De Sena Brandine G, Tran T, Ransick A, Suh G, Guo J, Kim AD, Parvez RK, Ruffins SW, Rutledge EA, Thornton ME, Grubbs B, McMahon JA, Smith AD, McMahon AP. PMID: 29870722; PMCID: PMC6510587.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    47. Disparate levels of beta-catenin activity determine nephron progenitor cell fate. Dev Biol. 2018 08 01; 440(1):13-21. Ramalingam H, Fessler AR, Das A, Valerius MT, Basta J, Robbins L, Brown AC, Oxburgh L, McMahon AP, Rauchman M, Carroll TJ. PMID: 29705331; PMCID: PMC5988999.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    48. Synergistic co-regulation and competition by a SOX9-GLI-FOXA phasic transcriptional network coordinate chondrocyte differentiation transitions. PLoS Genet. 2018 04; 14(4):e1007346. Tan Z, Niu B, Tsang KY, Melhado IG, Ohba S, He X, Huang Y, Wang C, McMahon AP, Jauch R, Chan D, Zhang MQ, Cheah KSE. PMID: 29659575; PMCID: PMC5919691.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    49. Conserved and Divergent Features of Mesenchymal Progenitor Cell Types within the Cortical Nephrogenic Niche of the Human and Mouse Kidney. J Am Soc Nephrol. 2018 03; 29(3):806-824. Lindström NO, Guo J, Kim AD, Tran T, Guo Q, De Sena Brandine G, Ransick A, Parvez RK, Thornton ME, Baskin L, Grubbs B, McMahon JA, Smith AD, McMahon AP. PMID: 29449449; PMCID: PMC5827607.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansAnimalsCells
    50. Conserved and Divergent Molecular and Anatomic Features of Human and Mouse Nephron Patterning. J Am Soc Nephrol. 2018 03; 29(3):825-840. Lindström NO, Tran T, Guo J, Rutledge E, Parvez RK, Thornton ME, Grubbs B, McMahon JA, McMahon AP. PMID: 29449451; PMCID: PMC5827611.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
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    59. Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development. Dev Cell. 2017 05 22; 41(4):349-365.e3. Naiman N, Fujioka K, Fujino M, Valerius MT, Potter SS, McMahon AP, Kobayashi A. PMID: 28535371; PMCID: PMC5532731.
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    116. Signaling by SHH rescues facial defects following blockade in the brain. Dev Dyn. 2012 Feb; 241(2):247-56. Chong HJ, Young NM, Hu D, Jeong J, McMahon AP, Hallgrimsson B, Marcucio RS. PMID: 22275045; PMCID: PMC3547623.
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    121. Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation. Dev Cell. 2011 Jun 14; 20(6):788-801. Izzi L, Lévesque M, Morin S, Laniel D, Wilkes BC, Mille F, Krauss RS, McMahon AP, Allen BL, Charron F. PMID: 21664577; PMCID: PMC3432913.
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    122. A low resistance microfluidic system for the creation of stable concentration gradients in a defined 3D microenvironment. Biomed Microdevices. 2010 Dec; 12(6):1027-41. Amadi OC, Steinhauser ML, Nishi Y, Chung S, Kamm RD, McMahon AP, Lee RT. PMID: 20661647; PMCID: PMC3119200.
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    123. Dicer regulates the development of nephrogenic and ureteric compartments in the mammalian kidney. Kidney Int. 2011 Feb; 79(3):317-30. Nagalakshmi VK, Ren Q, Pugh MM, Valerius MT, McMahon AP, Yu J. PMID: 20944551; PMCID: PMC3214622.
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    124. Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis. Proc Natl Acad Sci U S A. 2010 May 25; 107(21):9736-41. Lee EY, Ji H, Ouyang Z, Zhou B, Ma W, Vokes SA, McMahon AP, Wong WH, Scott MP. PMID: 20460306; PMCID: PMC2906878.
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    125. Hedgehog signaling controls mesenchymal growth in the developing mammalian digestive tract. Development. 2010 May; 137(10):1721-9. Mao J, Kim BM, Rajurkar M, Shivdasani RA, McMahon AP. PMID: 20430747; PMCID: PMC2860252.
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    126. Macrophage Wnt7b is critical for kidney repair and regeneration. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4194-9. Lin SL, Li B, Rao S, Yeo EJ, Hudson TE, Nowlin BT, Pei H, Chen L, Zheng JJ, Carroll TJ, Pollard JW, McMahon AP, Lang RA, Duffield JS. PMID: 20160075; PMCID: PMC2840080.
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    128. Using mechanistic Bayesian networks to identify downstream targets of the sonic hedgehog pathway. BMC Bioinformatics. 2009 Dec 18; 10:433. Shah A, Tenzen T, McMahon AP, Woolf PJ. PMID: 20021670; PMCID: PMC3087349.
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    129. Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol. 2010 Jan; 176(1):85-97. Humphreys BD, Lin SL, Kobayashi A, Hudson TE, Nowlin BT, Bonventre JV, Valerius MT, McMahon AP, Duffield JS. PMID: 20008127; PMCID: PMC2797872.
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    130. An Hh-dependent pathway in lateral plate mesoderm enables the generation of left/right asymmetry. Curr Biol. 2009 Dec 01; 19(22):1912-7. Tsiairis CD, McMahon AP. PMID: 19879143; PMCID: PMC2787870.
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    131. Hedgehog signalling: Kif7 is not that fishy after all. Curr Biol. 2009 Sep 15; 19(17):R729-31. Ingham PW, McMahon AP. PMID: 19906571.
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    132. High-resolution gene expression analysis of the developing mouse kidney defines novel cellular compartments within the nephron progenitor population. Dev Biol. 2009 Sep 15; 333(2):312-23. Mugford JW, Yu J, Kobayashi A, McMahon AP. PMID: 19591821; PMCID: PMC2748313.
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    134. Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis. Cell Stem Cell. 2009 Jun 05; 4(6):559-67. Hofmann I, Stover EH, Cullen DE, Mao J, Morgan KJ, Lee BH, Kharas MG, Miller PG, Cornejo MG, Okabe R, Armstrong SA, Ghilardi N, Gould S, de Sauvage FJ, McMahon AP, Gilliland DG. PMID: 19497284; PMCID: PMC3065323.
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    136. Modeling the spatio-temporal network that drives patterning in the vertebrate central nervous system. Biochim Biophys Acta. 2009 Apr; 1789(4):299-305. Nishi Y, Ji H, Wong WH, McMahon AP, Vokes SA. PMID: 19445894.
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    137. Motor neurons with axial muscle projections specified by Wnt4/5 signaling. Neuron. 2009 Mar 12; 61(5):708-20. Agalliu D, Takada S, Agalliu I, McMahon AP, Jessell TM. PMID: 19285468; PMCID: PMC2741579.
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    138. Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2623-8. Wang Y, Zhou Z, Walsh CT, McMahon AP. PMID: 19196978; PMCID: PMC2650314.
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    139. A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney. Development. 2009 Jan; 136(1):161-71. Yu J, Carroll TJ, Rajagopal J, Kobayashi A, Ren Q, McMahon AP. PMID: 19060336; PMCID: PMC2685965.
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    140. Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature. Science. 2008 Nov 21; 322(5905):1247-50. Stenman JM, Rajagopal J, Carroll TJ, Ishibashi M, McMahon J, McMahon AP. PMID: 19023080.
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    142. Osteoblastic regulation of B lymphopoiesis is mediated by Gs{alpha}-dependent signaling pathways. Proc Natl Acad Sci U S A. 2008 Nov 04; 105(44):16976-81. Wu JY, Purton LE, Rodda SJ, Chen M, Weinstein LS, McMahon AP, Scadden DT, Kronenberg HM. PMID: 18957542; PMCID: PMC2579363.
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    143. A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb. Genes Dev. 2008 Oct 01; 22(19):2651-63. Vokes SA, Ji H, Wong WH, McMahon AP. PMID: 18832070; PMCID: PMC2559910.
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    144. Osr1 expression demarcates a multi-potent population of intermediate mesoderm that undergoes progressive restriction to an Osr1-dependent nephron progenitor compartment within the mammalian kidney. Dev Biol. 2008 Dec 01; 324(1):88-98. Mugford JW, Sipilä P, McMahon JA, McMahon AP. PMID: 18835385; PMCID: PMC2642884.
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    145. Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. Cancer Cell. 2008 Aug 12; 14(2):123-34. Schüller U, Heine VM, Mao J, Kho AT, Dillon AK, Han YG, Huillard E, Sun T, Ligon AH, Qian Y, Ma Q, Alvarez-Buylla A, McMahon AP, Rowitch DH, Ligon KL. PMID: 18691547; PMCID: PMC2597270.
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    147. Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network. Development. 2008 Aug; 135(15):2489-503. Dessaud E, McMahon AP, Briscoe J. PMID: 18621990.
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    148. Developmental biology. Grasping limb patterning. Science. 2008 Jul 18; 321(5887):350-2. Tabin CJ, McMahon AP. PMID: 18635784.
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    149. An eight residue fragment of an acyl carrier protein suffices for post-translational introduction of fluorescent pantetheinyl arms in protein modification in vitro and in vivo. J Am Chem Soc. 2008 Jul 30; 130(30):9925-30. Zhou Z, Koglin A, Wang Y, McMahon AP, Walsh CT. PMID: 18593165; PMCID: PMC2561316.
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    150. Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease. Genes Dev. 2008 Jun 15; 22(12):1662-76. Walkley CR, Qudsi R, Sankaran VG, Perry JA, Gostissa M, Roth SI, Rodda SJ, Snay E, Dunning P, Fahey FH, Alt FW, McMahon AP, Orkin SH. PMID: 18559481; PMCID: PMC2428063.
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    151. In vivo targeted deletion of calpain small subunit, Capn4, in cells of the osteoblast lineage impairs cell proliferation, differentiation, and bone formation. J Biol Chem. 2008 Jul 25; 283(30):21002-10. Shimada M, Greer PA, McMahon AP, Bouxsein ML, Schipani E. PMID: 18515801; PMCID: PMC2475719.
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    152. Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye. Dev Biol. 2008 Aug 01; 320(1):242-55. Dakubo GD, Mazerolle C, Furimsky M, Yu C, St-Jacques B, McMahon AP, Wallace VA. PMID: 18582859.
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    153. Hoxd11 specifies a program of metanephric kidney development within the intermediate mesoderm of the mouse embryo. Dev Biol. 2008 Jul 15; 319(2):396-405. Mugford JW, Sipilä P, Kobayashi A, Behringer RR, McMahon AP. PMID: 18485340; PMCID: PMC2580739.
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    155. Intrinsic epithelial cells repair the kidney after injury. Cell Stem Cell. 2008 Mar 06; 2(3):284-91. Humphreys BD, Valerius MT, Kobayashi A, Mugford JW, Soeung S, Duffield JS, McMahon AP, Bonventre JV. PMID: 18371453.
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    156. Disp1 regulates growth of mammalian long bones through the control of Ihh distribution. Dev Biol. 2008 May 15; 317(2):480-5. Tsiairis CD, McMahon AP. PMID: 18395198; PMCID: PMC2430380.
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    157. GUDMAP: the genitourinary developmental molecular anatomy project. J Am Soc Nephrol. 2008 Apr; 19(4):667-71. McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P, GUDMAP project. PMID: 18287559.
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    158. Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning. Development. 2008 Mar; 135(6):1097-106. Chamberlain CE, Jeong J, Guo C, Allen BL, McMahon AP. PMID: 18272593.
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    159. Transcriptional profiling of Wnt4 mutant mouse kidneys identifies genes expressed during nephron formation. Gene Expr Patterns. 2008 May; 8(5):297-306. Valerius MT, McMahon AP. PMID: 18346943; PMCID: PMC2435058.
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    160. Dicer-dependent pathways regulate chondrocyte proliferation and differentiation. Proc Natl Acad Sci U S A. 2008 Feb 12; 105(6):1949-54. Kobayashi T, Lu J, Cobb BS, Rodda SJ, McMahon AP, Schipani E, Merkenschlager M, Kronenberg HM. PMID: 18238902; PMCID: PMC2538863.
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    161. Beta-catenin is necessary to keep cells of ureteric bud/Wolffian duct epithelium in a precursor state. Dev Biol. 2008 Feb 01; 314(1):112-26. Marose TD, Merkel CE, McMahon AP, Carroll TJ. PMID: 18177851; PMCID: PMC2699621.
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    162. The cdx genes and retinoic acid control the positioning and segmentation of the zebrafish pronephros. PLoS Genet. 2007 Oct; 3(10):1922-38. Wingert RA, Selleck R, Yu J, Song HD, Chen Z, Song A, Zhou Y, Thisse B, Thisse C, McMahon AP, Davidson AJ. PMID: 17953490; PMCID: PMC2042002.
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    163. Wnt3 signaling in the epiblast is required for proper orientation of the anteroposterior axis. Dev Biol. 2007 Dec 01; 312(1):312-20. Barrow JR, Howell WD, Rule M, Hayashi S, Thomas KR, Capecchi MR, McMahon AP. PMID: 18028899.
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    164. Independent functions and mechanisms for homeobox gene Barx1 in patterning mouse stomach and spleen. Development. 2007 Oct; 134(20):3603-13. Kim BM, Miletich I, Mao J, McMahon AP, Sharpe PA, Shivdasani RA. PMID: 17855428.
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    165. Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFbeta2. Nat Genet. 2007 Oct; 39(10):1225-34. Zhou W, Lin L, Majumdar A, Li X, Zhang X, Liu W, Etheridge L, Shi Y, Martin J, Van de Ven W, Kaartinen V, Wynshaw-Boris A, McMahon AP, Rosenfeld MG, Evans SM. PMID: 17767158; PMCID: PMC5578467.
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    168. The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development. Genes Dev. 2007 May 15; 21(10):1244-57. Allen BL, Tenzen T, McMahon AP. PMID: 17504941; PMCID: PMC1865495.
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    186. Binding hot spot for invasion inhibitory molecules on Plasmodium falciparum apical membrane antigen 1. Infect Immun. 2005 Oct; 73(10):6981-9. Harris KS, Casey JL, Coley AM, Masciantonio R, Sabo JK, Keizer DW, Lee EF, McMahon A, Norton RS, Anders RF, Foley M. PMID: 16177378; PMCID: PMC1230972.
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    188. Apoptosis induced by vitamin A signaling is crucial for connecting the ureters to the bladder. Nat Genet. 2005 Oct; 37(10):1082-9. Batourina E, Tsai S, Lambert S, Sprenkle P, Viana R, Dutta S, Hensle T, Wang F, Niederreither K, McMahon AP, Carroll TJ, Mendelsohn CL. PMID: 16186816.
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    189. WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature. Nature. 2005 Sep 15; 437(7057):417-21. Lobov IB, Rao S, Carroll TJ, Vallance JE, Ito M, Ondr JK, Kurup S, Glass DA, Patel MS, Shu W, Morrisey EE, McMahon AP, Karsenty G, Lang RA. PMID: 16163358; PMCID: PMC4259146.
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    190. Fate-mapping of the epithelial seam during palatal fusion rules out epithelial-mesenchymal transformation. Dev Biol. 2005 Sep 15; 285(2):490-5. Vaziri Sani F, Hallberg K, Harfe BD, McMahon AP, Linde A, Gritli-Linde A. PMID: 16109396.
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    191. Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Dev Cell. 2005 Aug; 9(2):283-92. Carroll TJ, Park JS, Hayashi S, Majumdar A, McMahon AP. PMID: 16054034.
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    192. Neural crest origins of the neck and shoulder. Nature. 2005 Jul 21; 436(7049):347-55. Matsuoka T, Ahlberg PE, Kessaris N, Iannarelli P, Dennehy U, Richardson WD, McMahon AP, Koentges G. PMID: 16034409; PMCID: PMC1352163.
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    193. Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP. J Clin Invest. 2005 Jul; 115(7):1734-42. Kobayashi T, Soegiarto DW, Yang Y, Lanske B, Schipani E, McMahon AP, Kronenberg HM. PMID: 15951842; PMCID: PMC1143590.
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    194. Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development. Development. 2005 Jun; 132(12):2809-23. Kobayashi A, Kwan KM, Carroll TJ, McMahon AP, Mendelsohn CL, Behringer RR. PMID: 15930111.
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    195. Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell. 2005 May; 8(5):751-64. Glass DA, Bialek P, Ahn JD, Starbuck M, Patel MS, Clevers H, Taketo MM, Long F, McMahon AP, Lang RA, Karsenty G. PMID: 15866165.
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    196. Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction. Dev Cell. 2005 Feb; 8(2):229-39. Basson MA, Akbulut S, Watson-Johnson J, Simon R, Carroll TJ, Shakya R, Gross I, Martin GR, Lufkin T, McMahon AP, Wilson PD, Costantini FD, Mason IJ, Licht JD. PMID: 15691764.
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    197. Mouse brain organization revealed through direct genome-scale TF expression analysis. Science. 2004 Dec 24; 306(5705):2255-7. Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q. PMID: 15618518.
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    198. Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1. Development. 2005 Jan; 132(1):143-54. Jeong J, McMahon AP. PMID: 15576403.
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    199. Mouse Disp1 is required in sonic hedgehog-expressing cells for paracrine activity of the cholesterol-modified ligand. Development. 2005 Jan; 132(1):133-42. Tian H, Jeong J, Harfe BD, Tabin CJ, McMahon AP. PMID: 15576405.
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    200. Recent genetic studies of mouse kidney development. Curr Opin Genet Dev. 2004 Oct; 14(5):550-7. Yu J, McMahon AP, Valerius MT. PMID: 15380247.
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    201. Temporal requirement for hedgehog signaling in ventral telencephalic patterning. Development. 2004 Oct; 131(20):5031-40. Fuccillo M, Rallu M, McMahon AP, Fishell G. PMID: 15371303.
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    202. Hedgehog signaling: iguana debuts as a nuclear gatekeeper. Curr Biol. 2004 Aug 24; 14(16):R668-70. Vokes SA, McMahon AP. PMID: 15324687.
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    203. Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell. 2004 Aug 20; 118(4):517-28. Harfe BD, Scherz PJ, Nissim S, Tian H, McMahon AP, Tabin CJ. PMID: 15315763.
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    204. Hedgehog signaling is essential for endothelial tube formation during vasculogenesis. Development. 2004 Sep; 131(17):4371-80. Vokes SA, Yatskievych TA, Heimark RL, McMahon J, McMahon AP, Antin PB, Krieg PA. PMID: 15294868.
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    205. Dose dependency of Disp1 and genetic interaction between Disp1 and other hedgehog signaling components in the mouse. Development. 2004 Aug; 131(16):4021-33. Tian H, Tenzen T, McMahon AP. PMID: 15269168.
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    206. The limb bud Shh-Fgf feedback loop is terminated by expansion of former ZPA cells. Science. 2004 Jul 16; 305(5682):396-9. Scherz PJ, Harfe BD, McMahon AP, Tabin CJ. PMID: 15256670.
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    207. Sonic hedgehog signaling is required for expansion of granule neuron precursors and patterning of the mouse cerebellum. Dev Biol. 2004 Jun 15; 270(2):393-410. Lewis PM, Gritli-Linde A, Smeyne R, Kottmann A, McMahon AP. PMID: 15183722.
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    208. Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate. J Clin Invest. 2004 Jun; 113(12):1692-700. Rice R, Spencer-Dene B, Connor EC, Gritli-Linde A, McMahon AP, Dickson C, Thesleff I, Rice DP. PMID: 15199404; PMCID: PMC420504.
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    209. Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia. Genes Dev. 2004 Apr 15; 18(8):937-51. Jeong J, Mao J, Tenzen T, Kottmann AH, McMahon AP. PMID: 15107405; PMCID: PMC395852.
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    210. Derivation of embryonic stem-cell lines from human blastocysts. N Engl J Med. 2004 Mar 25; 350(13):1353-6. Cowan CA, Klimanskaya I, McMahon J, Atienza J, Witmyer J, Zucker JP, Wang S, Morton CC, McMahon AP, Powers D, Melton DA. PMID: 14999088.
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    211. SOX2, a persistent marker for multipotential neural stem cells derived from embryonic stem cells, the embryo or the adult. Dev Neurosci. 2004 Mar-Aug; 26(2-4):148-65. Ellis P, Fagan BM, Magness ST, Hutton S, Taranova O, Hayashi S, McMahon A, Rao M, Pevny L. PMID: 15711057.
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    212. Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton. Development. 2004 Mar; 131(6):1309-18. Long F, Chung UI, Ohba S, McMahon J, Kronenberg HM, McMahon AP. PMID: 14973297.
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    213. Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice. Science. 2003 Oct 03; 302(5642):113-7. Clement AM, Nguyen MD, Roberts EA, Garcia ML, Boillée S, Rule M, McMahon AP, Doucette W, Siwek D, Ferrante RJ, Brown RH, Julien JP, Goldstein LS, Cleveland DW. PMID: 14526083.
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    214. Maternal inheritance of Cre activity in a Sox2Cre deleter strain. Genesis. 2003 Oct; 37(2):51-3. Hayashi S, Tenzen T, McMahon AP. PMID: 14595839.
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    215. Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches. Neuron. 2003 Sep 11; 39(6):937-50. Machold R, Hayashi S, Rutlin M, Muzumdar MD, Nery S, Corbin JG, Gritli-Linde A, Dellovade T, Porter JA, Rubin LL, Dudek H, McMahon AP, Fishell G. PMID: 12971894.
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    216. Combined activities of hedgehog signaling inhibitors regulate pancreas development. Development. 2003 Oct; 130(20):4871-9. Kawahira H, Ma NH, Tzanakakis ES, McMahon AP, Chuang PT, Hebrok M. PMID: 12917290.
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    217. Collecting duct-specific gene inactivation of alphaENaC in the mouse kidney does not impair sodium and potassium balance. J Clin Invest. 2003 Aug; 112(4):554-65. Rubera I, Loffing J, Palmer LG, Frindt G, Fowler-Jaeger N, Sauter D, Carroll T, McMahon A, Hummler E, Rossier BC. PMID: 12925696; PMCID: PMC171384.
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    218. Retinal ganglion cell-derived sonic hedgehog signaling is required for optic disc and stalk neuroepithelial cell development. Development. 2003 Jul; 130(13):2967-80. Dakubo GD, Wang YP, Mazerolle C, Campsall K, McMahon AP, Wallace VA. PMID: 12756179.
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    219. Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development. Development. 2003 Jul; 130(14):3175-85. Majumdar A, Vainio S, Kispert A, McMahon J, McMahon AP. PMID: 12783789.
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    220. Loss of Emx2 function leads to ectopic expression of Wnt1 in the developing telencephalon and cortical dysplasia. Development. 2003 May; 130(10):2275-87. Ligon KL, Echelard Y, Assimacopoulos S, Danielian PS, Kaing S, Grove EA, McMahon AP, Rowitch DH. PMID: 12668639.
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    221. FGFR1 is independently required in both developing mid- and hindbrain for sustained response to isthmic signals. EMBO J. 2003 Apr 15; 22(8):1811-23. Trokovic R, Trokovic N, Hernesniemi S, Pirvola U, Vogt Weisenhorn DM, Rossant J, McMahon AP, Wurst W, Partanen J. PMID: 12682014; PMCID: PMC154461.
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    222. The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance. Cell. 2003 Apr 04; 113(1):11-23. Charron F, Stein E, Jeong J, McMahon AP, Tessier-Lavigne M. PMID: 12679031.
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    223. Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge. Genes Dev. 2003 Feb 01; 17(3):394-409. Barrow JR, Thomas KR, Boussadia-Zahui O, Moore R, Kemler R, Capecchi MR, McMahon AP. PMID: 12569130; PMCID: PMC195987.
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    224. Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung. Genes Dev. 2003 Feb 01; 17(3):342-7. Chuang PT, Kawcak T, McMahon AP. PMID: 12569124; PMCID: PMC195990.
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    225. Branching morphogenesis of the lung: new molecular insights into an old problem. Trends Cell Biol. 2003 Feb; 13(2):86-91. Chuang PT, McMahon AP. PMID: 12559759.
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    226. Developmental roles and clinical significance of hedgehog signaling. Curr Top Dev Biol. 2003; 53:1-114. McMahon AP, Ingham PW, Tabin CJ. PMID: 12509125.
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    227. Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain. Mech Dev. 2002 Dec; 119 Suppl 1:S97-S101. Hayashi S, Lewis P, Pevny L, McMahon AP. PMID: 14516668.
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    228. Shh signaling within the dental epithelium is necessary for cell proliferation, growth and polarization. Development. 2002 Dec; 129(23):5323-37. Gritli-Linde A, Bei M, Maas R, Zhang XM, Linde A, McMahon AP. PMID: 12403705.
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    229. A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord. Genes Dev. 2002 Nov 15; 16(22):2849-64. Wijgerde M, McMahon JA, Rule M, McMahon AP. PMID: 12435628; PMCID: PMC187482.
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    230. Dorsoventral patterning is established in the telencephalon of mutants lacking both Gli3 and Hedgehog signaling. Development. 2002 Nov; 129(21):4963-74. Rallu M, Machold R, Gaiano N, Corbin JG, McMahon AP, Fishell G. PMID: 12397105.
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    231. Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain. Gene Expr Patterns. 2002 Nov; 2(1-2):93-7. Hayashi S, Lewis P, Pevny L, McMahon AP. PMID: 12617844.
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    232. Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney. Development. 2002 Nov; 129(22):5301-12. Yu J, Carroll TJ, McMahon AP. PMID: 12399320.
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    233. A sonic hedgehog-dependent signaling relay regulates growth of diencephalic and mesencephalic primordia in the early mouse embryo. Development. 2002 Oct; 129(20):4807-19. Ishibashi M, McMahon AP. PMID: 12361972.
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    234. Cholesterol modification of Hedgehog family proteins. J Clin Invest. 2002 Sep; 110(5):591-6. Jeong J, McMahon AP. PMID: 12208857; PMCID: PMC151115.
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    235. Development of normal retinal organization depends on Sonic hedgehog signaling from ganglion cells. Nat Neurosci. 2002 Sep; 5(9):831-2. Wang YP, Dakubo G, Howley P, Campsall KD, Mazarolle CJ, Shiga SA, Lewis PM, McMahon AP, Wallace VA. PMID: 12195432.
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    236. Transient expression of the bHLH factor neurogenin-2 marks a subpopulation of neural crest cells biased for a sensory but not a neuronal fate. Proc Natl Acad Sci U S A. 2002 Jun 11; 99(12):8084-9. Zirlinger M, Lo L, McMahon J, McMahon AP, Anderson DJ. PMID: 12060754; PMCID: PMC123024.
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    237. A mitogen gradient of dorsal midline Wnts organizes growth in the CNS. Development. 2002 May; 129(9):2087-98. Megason SG, McMahon AP. PMID: 11959819.
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    238. Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse. Dev Biol. 2002 Apr 15; 244(2):305-18. Hayashi S, McMahon AP. PMID: 11944939.
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    239. Wnt-1 and Wnt-4 regulate thymic cellularity. Eur J Immunol. 2002 04; 32(4):967-71. Mulroy T, McMahon JA, Burakoff SJ, McMahon AP, Sen J. PMID: 11920562.
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    240. Dach1, a vertebrate homologue of Drosophila dachshund, is expressed in the developing eye and ear of both chick and mouse and is regulated independently of Pax and Eya genes. Mech Dev. 2002 Feb; 111(1-2):75-87. Heanue TA, Davis RJ, Rowitch DH, Kispert A, McMahon AP, Mardon G, Tabin CJ. PMID: 11804780.
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    241. Hedgehog is required for murine yolk sac angiogenesis. Development. 2002 Jan; 129(2):361-72. Byrd N, Becker S, Maye P, Narasimhaiah R, St-Jacques B, Zhang X, McMahon J, McMahon A, Grabel L. PMID: 11807029.
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    242. Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development. 2001 Dec; 128(24):5099-108. Long F, Zhang XM, Karp S, Yang Y, McMahon AP. PMID: 11748145.
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    243. Hedgehog signaling in animal development: paradigms and principles. Genes Dev. 2001 Dec 01; 15(23):3059-87. Ingham PW, McMahon AP. PMID: 11731473.
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    244. BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation. Development. 2001 Nov; 128(22):4523-34. Minina E, Wenzel HM, Kreschel C, Karp S, Gaffield W, McMahon AP, Vortkamp A. PMID: 11714677.
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    245. Wnt7b regulates placental development in mice. Dev Biol. 2001 Sep 15; 237(2):324-32. Parr BA, Cornish VA, Cybulsky MI, McMahon AP. PMID: 11543617.
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    246. Alcohol hypersensitivity, increased locomotion, and spontaneous myoclonus in mice lacking the potassium channels Kv3.1 and Kv3.3. J Neurosci. 2001 Sep 01; 21(17):6657-65. Espinosa F, McMahon A, Chan E, Wang S, Ho CS, Heintz N, Joho RH. PMID: 11517255; PMCID: PMC6763102.
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    247. The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides. Dev Biol. 2001 Aug 15; 236(2):364-86. Gritli-Linde A, Lewis P, McMahon AP, Linde A. PMID: 11476578.
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    248. Dynamic interaction of S5 and S6 during voltage-controlled gating in a potassium channel. J Gen Physiol. 2001 Aug; 118(2):157-70. Espinosa F, Fleischhauer R, McMahon A, Joho RH. PMID: 11479343; PMCID: PMC2233824.
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    249. Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node. Cell. 2001 Jul 27; 106(2):781-92. Zhang XM, Ramalho-Santos M, McMahon AP. PMID: 11517919.
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    250. Developmental biology. Vesicles and the spinal cord. Nature. 2001 Jul 12; 412(6843):136-7. Jeong J, McMahon AP. PMID: 11449254.
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    251. Six3 promotes the formation of ectopic optic vesicle-like structures in mouse embryos. Dev Dyn. 2001 Jul; 221(3):342-9. Lagutin O, Zhu CC, Furuta Y, Rowitch DH, McMahon AP, Oliver G. PMID: 11458394.
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    252. Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R asymmetry by the mouse node. Cell. 2001 Jun 15; 105(6):781-92. Zhang XM, Ramalho-Santos M, McMahon AP. PMID: 11440720.
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    253. Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1. Cell. 2001 Jun 01; 105(5):599-612. Lewis PM, Dunn MP, McMahon JA, Logan M, Martin JF, St-Jacques B, McMahon AP. PMID: 11389830.
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    254. Activation of expression of hedgehog target genes in basal cell carcinomas. J Invest Dermatol. 2001 May; 116(5):739-42. Bonifas JM, Pennypacker S, Chuang PT, McMahon AP, Williams M, Rosenthal A, De Sauvage FJ, Epstein EH. PMID: 11348463.
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    255. Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. Development. 2001 Apr; 128(8):1253-64. Brault V, Moore R, Kutsch S, Ishibashi M, Rowitch DH, McMahon AP, Sommer L, Boussadia O, Kemler R. PMID: 11262227.
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    256. Hedgehog signaling is required for pituitary gland development. Development. 2001 Feb; 128(3):377-86. Treier M, O'Connell S, Gleiberman A, Price J, Szeto DP, Burgess R, Chuang PT, McMahon AP, Rosenfeld MG. PMID: 11152636.
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    257. Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development. J Clin Invest. 2001 Feb; 107(3):295-304. Chung UI, Schipani E, McMahon AP, Kronenberg HM. PMID: 11160153; PMCID: PMC199199.
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    258. Characterization of Pax-2 regulatory sequences that direct transgene expression in the Wolffian duct and its derivatives. Dev Biol. 2001 Jan 01; 229(1):128-40. Kuschert S, Rowitch DH, Haenig B, McMahon AP, Kispert A. PMID: 11133159.
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    259. Regulation of pancreas development by hedgehog signaling. Development. 2000 Nov; 127(22):4905-13. Hebrok M, Kim SK, St Jacques B, McMahon AP, Melton DA. PMID: 11044404.
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    260. Sonic hedgehog regulates growth and morphogenesis of the tooth. Development. 2000 Nov; 127(22):4775-85. Dassule HR, Lewis P, Bei M, Maas R, McMahon AP. PMID: 11044393.
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    261. Secreted molecules in metanephric induction. J Am Soc Nephrol. 2000 Nov; 11 Suppl 16:S116-9. Carroll TJ, McMahon AP. PMID: 11065341.
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    262. Neural patterning: the role of Nkx genes in the ventral spinal cord. Genes Dev. 2000 Sep 15; 14(18):2261-4. McMahon AP. PMID: 10995382.
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    263. Localization of 17beta-hydroxysteroid dehydrogenase/17-ketosteroid reductase isoform expression in the developing mouse testis--androstenedione is the major androgen secreted by fetal/neonatal leydig cells. Endocrinology. 2000 Jul; 141(7):2631-7. O'Shaughnessy PJ, Baker PJ, Heikkilä M, Vainio S, McMahon AP. PMID: 10875268.
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    264. Hedgehog signals regulate multiple aspects of gastrointestinal development. Development. 2000 Jun; 127(12):2763-72. Ramalho-Santos M, Melton DA, McMahon AP. PMID: 10821773.
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    265. Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis. Development. 2000 Apr; 127(8):1671-9. Chai Y, Jiang X, Ito Y, Bringas P, Han J, Rowitch DH, Soriano P, McMahon AP, Sucov HM. PMID: 10725243.
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    266. A model for anteroposterior patterning of the vertebrate limb based on sequential long- and short-range Shh signalling and Bmp signalling. Development. 2000 Apr; 127(7):1337-48. Drossopoulou G, Lewis KE, Sanz-Ezquerro JJ, Nikbakht N, McMahon AP, Hofmann C, Tickle C. PMID: 10704381.
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    267. Fate of the mammalian cardiac neural crest. Development. 2000 Apr; 127(8):1607-16. Jiang X, Rowitch DH, Soriano P, McMahon AP, Sucov HM. PMID: 10725237.
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    277. Signal relay by BMP antagonism controls the SHH/FGF4 feedback loop in vertebrate limb buds. Nature. 1999 Oct 07; 401(6753):598-602. Zúñiga A, Haramis AP, McMahon AP, Zeller R. PMID: 10524628.
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    278. Schwann Cell-Derived Desert Hedgehog Signals Nerve Sheath Formation. Ann N Y Acad Sci. 1999 Oct; 883(1):196-202. Mirsky R, Parmantier E, McMahon AP, Jessen KR. PMID: 29086927.
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    283. Cystic malformation of the posterior cerebellar vermis in transgenic mice that ectopically express Engrailed-1, a homeodomain transcription factor. Teratology. 1999 Jul; 60(1):22-8. Rowitch DH, Danielian PS, McMahon AP, Zec N. PMID: 10413335.
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    284. Modulation of early but not later stages of programmed cell death in embryonic avian spinal cord by sonic hedgehog. Mol Cell Neurosci. 1999 May; 13(5):348-61. Oppenheim RW, Homma S, Marti E, Prevette D, Wang S, Yaginuma H, McMahon AP. PMID: 10356297.
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    287. Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. Nature. 1999 Feb 18; 397(6720):617-21. Chuang PT, McMahon AP. PMID: 10050855.
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    297. Inhibitory action of BMPs on Pax1 expression and on shoulder girdle formation during limb development. Dev Dyn. 1998 Oct; 213(2):199-206. Hofmann C, Drossopoulou G, McMahon A, Balling R, Tickle C. PMID: 9786420.
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    299. Sonic hedgehog regulates branching morphogenesis in the mammalian lung. Curr Biol. 1998 Sep 24; 8(19):1083-6. Pepicelli CV, Lewis PM, McMahon AP. PMID: 9768363.
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    354. Proteolytic processing yields two secreted forms of sonic hedgehog. Mol Cell Biol. 1995 Apr; 15(4):2294-303. Bumcrot DA, Takada R, McMahon AP. PMID: 7891723; PMCID: PMC230457.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    355. Dorsalizing signal Wnt-7a required for normal polarity of D-V and A-P axes of mouse limb. Nature. 1995 Mar 23; 374(6520):350-3. Parr BA, McMahon AP. PMID: 7885472.
      View in: PubMed   Mentions: 124     Fields:    Translation:AnimalsCells
    356. Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4. Nature. 1994 Dec 15; 372(6507):679-83. Stark K, Vainio S, Vassileva G, McMahon AP. PMID: 7990960.
      View in: PubMed   Mentions: 327     Fields:    Translation:AnimalsCells
    357. Mouse development. Winged-helix in axial patterning. Curr Biol. 1994 Oct 01; 4(10):903-6. McMahon AP. PMID: 7850424.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    358. Differential transformation of mammary epithelial cells by Wnt genes. Mol Cell Biol. 1994 Sep; 14(9):6278-86. Wong GT, Gavin BJ, McMahon AP. PMID: 8065359; PMCID: PMC359154.
      View in: PubMed   Mentions: 95     Fields:    Translation:AnimalsCells
    359. Cis-acting regulatory sequences governing Wnt-1 expression in the developing mouse CNS. Development. 1994 Aug; 120(8):2213-24. Echelard Y, Vassileva G, McMahon AP. PMID: 7925022.
      View in: PubMed   Mentions: 110     Fields:    Translation:AnimalsCells
    360. Wnt-1-dependent regulation of local E-cadherin and alpha N-catenin expression in the embryonic mouse brain. Development. 1994 Aug; 120(8):2225-34. Shimamura K, Hirano S, McMahon AP, Takeichi M. PMID: 7925023.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    361. Experimental control of axial pattern in the chick blastoderm by local expression of Wnt and activin: the role of HNK-1 positive cells. Dev Biol. 1994 Aug; 164(2):513-27. Cooke J, Takada S, McMahon A. PMID: 7519156.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    362. Wnt genes and vertebrate development. Curr Opin Genet Dev. 1994 Aug; 4(4):523-8. Parr BA, McMahon AP. PMID: 7950319.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    363. Induction of tyrosine hydroxylase gene expression by a nonneuronal nonpituitary-mediated mechanism in immobilization stress. Proc Natl Acad Sci U S A. 1994 Jun 21; 91(13):5937-41. Nankova B, Kvetnanský R, McMahon A, Viskupic E, Hiremagalur B, Frankle G, Fukuhara K, Kopin IJ, Sabban EL. PMID: 7912437; PMCID: PMC44112.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    364. Evidence for a mitogenic effect of Wnt-1 in the developing mammalian central nervous system. Development. 1994 Jun; 120(6):1453-71. Dickinson ME, Krumlauf R, McMahon AP. PMID: 8050356.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    365. Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue. Cancer Res. 1994 May 15; 54(10):2615-21. Huguet EL, McMahon JA, McMahon AP, Bicknell R, Harris AL. PMID: 8168088.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCells
    366. DNA affinity cleaving analysis of homeodomain-DNA interaction: identification of homeodomain consensus sites in genomic DNA. Proc Natl Acad Sci U S A. 1994 Jan 04; 91(1):118-22. Shang Z, Ebright YW, Iler N, Pendergrast PS, Echelard Y, McMahon AP, Ebright RH, Abate C. PMID: 7904065; PMCID: PMC42897.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    367. Independent regulatory elements in the nestin gene direct transgene expression to neural stem cells or muscle precursors. Neuron. 1994 Jan; 12(1):11-24. Zimmerman L, Parr B, Lendahl U, Cunningham M, McKay R, Gavin B, Mann J, Vassileva G, McMahon A. PMID: 8292356.
      View in: PubMed   Mentions: 222     Fields:    Translation:AnimalsCells
    368. Wnt-3a regulates somite and tailbud formation in the mouse embryo. Genes Dev. 1994 Jan; 8(2):174-89. Takada S, Stark KL, Shea MJ, Vassileva G, McMahon JA, McMahon AP. PMID: 8299937.
      View in: PubMed   Mentions: 224     Fields:    Translation:AnimalsCells
    369. The hedgehog gene family in Drosophila and vertebrate development. Dev Suppl. 1994; 43-51. Fietz MJ, Concordet JP, Barbosa R, Johnson R, Krauss S, McMahon AP, Tabin C, Ingham PW. PMID: 7579523.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    370. Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell. 1993 Dec 31; 75(7):1417-30. Echelard Y, Epstein DJ, St-Jacques B, Shen L, Mohler J, McMahon JA, McMahon AP. PMID: 7916661.
      View in: PubMed   Mentions: 591     Fields:    Translation:AnimalsCells
    371. Wnt family proteins are secreted and associated with the cell surface. Mol Biol Cell. 1993 Dec; 4(12):1267-75. Smolich BD, McMahon JA, McMahon AP, Papkoff J. PMID: 8167409; PMCID: PMC275763.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    372. Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds. Development. 1993 Sep; 119(1):247-61. Parr BA, Shea MJ, Vassileva G, McMahon AP. PMID: 8275860.
      View in: PubMed   Mentions: 184     Fields:    Translation:Animals
    373. Cell signalling in induction and anterior-posterior patterning of the vertebrate central nervous system. Curr Opin Neurobiol. 1993 Feb; 3(1):4-7. McMahon AP. PMID: 8453288.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    374. Cloning developmentally regulated gene families. Methods Enzymol. 1993; 225:653-63. Gavin BJ, McMahon AP. PMID: 8231877.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    375. Factors influencing frequency production of transgenic mice. Methods Enzymol. 1993; 225:771-81. Mann JR, McMahon AP. PMID: 8231885.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    376. Regulation of expression of dopamine beta-hydroxylase in PC12 cells by glucocorticoids and cyclic AMP analogues. J Neurochem. 1992 Dec; 59(6):2040-7. McMahon A, Sabban EL. PMID: 1359011.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    377. The role of Wnt genes in vertebrate development. Curr Opin Genet Dev. 1992 Aug; 2(4):562-6. Dickinson ME, McMahon AP. PMID: 1388080.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    378. Expression pattern of Motch, a mouse homolog of Drosophila Notch, suggests an important role in early postimplantation mouse development. Development. 1992 Jul; 115(3):737-44. Del Amo FF, Smith DE, Swiatek PJ, Gendron-Maguire M, Greenspan RJ, McMahon AP, Gridley T. PMID: 1425352.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    379. Regulation of tyrosine hydroxylase and dopamine beta-hydroxylase mRNA levels in rat adrenals by a single and repeated immobilization stress. J Neurochem. 1992 Jun; 58(6):2124-30. McMahon A, Kvetnanský R, Fukuhara K, Weise VK, Kopin IJ, Sabban EL. PMID: 1349344.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    380. The midbrain-hindbrain phenotype of Wnt-1-/Wnt-1- mice results from stepwise deletion of engrailed-expressing cells by 9.5 days postcoitum. Cell. 1992 May 15; 69(4):581-95. McMahon AP, Joyner AL, Bradley A, McMahon JA. PMID: 1534034.
      View in: PubMed   Mentions: 128     Fields:    Translation:AnimalsCells
    381. Differential regulation of the Wnt gene family during pregnancy and lactation suggests a role in postnatal development of the mammary gland. Mol Cell Biol. 1992 May; 12(5):2418-23. Gavin BJ, McMahon AP. PMID: 1373817; PMCID: PMC364414.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    382. Regulated expression of the tyrosine hydroxylase gene by membrane depolarization. Identification of the responsive element and possible second messengers. J Biol Chem. 1992 Apr 15; 267(11):7563-9. Kilbourne EJ, Nankova BB, Lewis EJ, McMahon A, Osaka H, Sabban DB, Sabban EL. PMID: 1348505.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    383. The Wnt family of cell signalling molecules in postimplantation development of the mouse. Ciba Found Symp. 1992; 165:199-212; discussion 212-8. McMahon AP, Gavin BJ, Parr B, Bradley A, McMahon JA. PMID: 1516469.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    384. Membrane depolarization by isotonic or hypertonic KCl: differential effects on mRNA levels of tyrosine hydroxylase and dopamine beta-hydroxylase mRNA in PC12 cells. J Neurosci Methods. 1991 Dec; 40(2-3):193-202. Kilbourne EJ, McMahon A, Sabban EL. PMID: 1686923.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    385. FGFR-4, a new member of the fibroblast growth factor receptor family, expressed in the definitive endoderm and skeletal muscle lineages of the mouse. Development. 1991 Oct; 113(2):641-51. Stark KL, McMahon JA, McMahon AP. PMID: 1723680.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    386. Xwnt-8, a Xenopus Wnt-1/int-1-related gene responsive to mesoderm-inducing growth factors, may play a role in ventral mesodermal patterning during embryogenesis. Development. 1991 Apr; 111(4):1045-55. Christian JL, McMahon JA, McMahon AP, Moon RT. PMID: 1879349.
      View in: PubMed   Mentions: 74     Fields:    Translation:Animals
    387. Isolation of cDNAs partially encoding four Xenopus Wnt-1/int-1-related proteins and characterization of their transient expression during embryonic development. Dev Biol. 1991 Feb; 143(2):230-4. Christian JL, Gavin BJ, McMahon AP, Moon RT. PMID: 1991549.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    388. A new nomenclature for int-1 and related genes: the Wnt gene family. Cell. 1991 Jan 25; 64(2):231. Nusse R, Brown A, Papkoff J, Scambler P, Shackleford G, McMahon A, Moon R, Varmus H. PMID: 1846319.
      View in: PubMed   Mentions: 124     Fields:    Translation:HumansAnimalsCells
    389. Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. Genes Dev. 1990 Dec; 4(12B):2319-32. Gavin BJ, McMahon JA, McMahon AP. PMID: 2279700.
      View in: PubMed   Mentions: 83     Fields:    Translation:AnimalsCells
    390. The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain. Cell. 1990 Sep 21; 62(6):1073-85. McMahon AP, Bradley A. PMID: 2205396.
      View in: PubMed   Mentions: 419     Fields:    Translation:AnimalsCells
    391. Generation of diversity in nonerythroid spectrins. Multiple polypeptides are predicted by sequence analysis of cDNAs encompassing the coding region of human nonerythroid alpha-spectrin. J Biol Chem. 1990 Mar 15; 265(8):4427-33. Moon RT, McMahon AP. PMID: 2307671.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    392. Rat dopamine beta-hydroxylase: molecular cloning and characterization of the cDNA and regulation of the mRNA by reserpine. J Neurosci Res. 1990 Mar; 25(3):395-404. McMahon A, Geertman R, Sabban EL. PMID: 2325165.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    393. Developmental expression of the putative transcription factor Egr-1 suggests that Egr-1 and c-fos are coregulated in some tissues. Development. 1990 Feb; 108(2):281-7. McMahon AP, Champion JE, McMahon JA, Sukhatme VP. PMID: 2351070.
      View in: PubMed   Mentions: 32     Fields:    Translation:Animals
    394. Effect of compounds which disrupt proton gradients on secretion of neurosecretory proteins from PC12 pheochromocytoma cells. Neuroscience. 1990; 38(2):561-70. Sabban EL, Schwartz J, McMahon A. PMID: 2175857.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    395. Nucleotide sequence, chromosomal localization and developmental expression of the mouse int-1-related gene. Development. 1989 Nov; 107(3):643-50. McMahon JA, McMahon AP. PMID: 2693041.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    396. Endoglycosidase H susceptibility of secreted and intracellular forms of dopamine beta-hydroxylase. Biochem Int. 1989 Oct; 19(4):769-75. Sabban EL, McMahon A, Kuhn LJ. PMID: 2515859.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    397. Ectopic expression of the proto-oncogene int-1 in Xenopus embryos leads to duplication of the embryonic axis. Cell. 1989 Sep 22; 58(6):1075-84. McMahon AP, Moon RT. PMID: 2673541.
      View in: PubMed   Mentions: 142     Fields:    Translation:AnimalsCells
    398. Expression pattern of the FGF-related proto-oncogene int-2 suggests multiple roles in fetal development. Development. 1989 Jan; 105(1):131-6. Wilkinson DG, Bhatt S, McMahon AP. PMID: 2680421.
      View in: PubMed   Mentions: 50     Fields:    Translation:Animals
    399. int-1--a proto-oncogene involved in cell signalling. Development. 1989; 107 Suppl:161-7. McMahon AP, Moon RT. PMID: 2534596.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    400. Expression of the FGF-related proto-oncogene int-2 during gastrulation and neurulation in the mouse. EMBO J. 1988 Mar; 7(3):691-5. Wilkinson DG, Peters G, Dickson C, McMahon AP. PMID: 3293998; PMCID: PMC454374.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    401. Effects of ionizing radiation and pretreatment with [D-Leu6,des-Gly10] luteinizing hormone-releasing hormone ethylamide on developing rat ovarian follicles. Cancer Res. 1987 Oct 01; 47(19):5005-8. Jarrell J, YoungLai EV, McMahon A, Barr R, O'Connell G, Belbeck L. PMID: 3113726.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    402. Structure and evolution of a non-erythroid spectrin, human alpha-fodrin. Biochem Soc Trans. 1987 Oct; 15(5):804-7. McMahon AP, Moon RT. PMID: 3691949.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    403. Expression of the proto-oncogene int-1 is restricted to specific neural cells in the developing mouse embryo. Cell. 1987 Jul 03; 50(1):79-88. Wilkinson DG, Bailes JA, McMahon AP. PMID: 3594565.
      View in: PubMed   Mentions: 117     Fields:    Translation:AnimalsCells
    404. Ovarian toxicity of cyclophosphamide alone and in combination with ovarian irradiation in the rat. Cancer Res. 1987 May 01; 47(9):2340-3. Jarrell J, Lai EV, Barr R, McMahon A, Belbeck L, O'Connell G. PMID: 3105875.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    405. A molecular analysis of mouse development from 8 to 10 days post coitum detects changes only in embryonic globin expression. Development. 1987 Apr; 99(4):493-500. Wilkinson DG, Bailes JA, Champion JE, McMahon AP. PMID: 2444404.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    406. cDNA cloning, sequencing and chromosome mapping of a non-erythroid spectrin, human alpha-fodrin. Differentiation. 1987; 34(1):68-78. McMahon AP, Giebelhaus DH, Champion JE, Bailes JA, Lacey S, Carritt B, Henchman SK, Moon RT. PMID: 3038643.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    407. An analysis of the effects of increasing doses of ionizing radiation to the exteriorized rat ovary on follicular development, atresia, and serum gonadotropin levels. Am J Obstet Gynecol. 1986 Feb; 154(2):306-9. Jarrell J, YoungLai EV, Barr R, O'Connell G, Belbeck L, McMahon A. PMID: 3080889.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    408. Introduction of cloned DNA into sea urchin egg cytoplasm: replication and persistence during embryogenesis. Dev Biol. 1985 Apr; 108(2):420-30. McMahon AP, Flytzanis CN, Hough-Evans BR, Katula KS, Britten RJ, Davidson EH. PMID: 3000854.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    409. Persistence and integration of cloned DNA in postembryonic sea urchins. Dev Biol. 1985 Apr; 108(2):431-42. Flytzanis CN, McMahon AP, Hough-Evans BR, Katula KS, Britten RJ, Davidson EH. PMID: 3000855.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    410. Inducible expression of a cloned heat shock fusion gene in sea urchin embryos. Proc Natl Acad Sci U S A. 1984 Dec; 81(23):7490-4. McMahon AP, Novak TJ, Britten RJ, Davidson EH. PMID: 6594699; PMCID: PMC392172.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    411. Oocyte specific regulation of PGK-1 isozyme activity in female germ cells of the mouse. Genet Res. 1983 Aug; 42(1):77-89. McMahon A. PMID: 6628991.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    412. X-chromosome inactivation mosaicism in the three germ layers and the germ line of the mouse embryo. J Embryol Exp Morphol. 1983 Apr; 74:207-20. McMahon A, Fosten M, Monk M. PMID: 6886595.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    413. X-chromosome activity in female mouse embryos heterozygous for Pgk-1 and Searle's translocation, T(X; 16) 16H. Genet Res. 1983 Feb; 41(1):69-83. McMahon A, Monk M. PMID: 6840549.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    414. Random X-chromosome inactivation in female primordial germ cells in the mouse. J Embryol Exp Morphol. 1981 Aug; 64:251-8. McMahon A, Fosten M, Monk M. PMID: 7310304.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
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