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Andre J Ouellette, PhD

TitleProfessor of Pathology
InstitutionUniversity of Southern California
DepartmentPathology
AddressNRT 7505
Health Sciences Campus
Los Angeles CA 90089-9601
Phone+1 323 442 7959
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    Collapse Research 
    Collapse Research Activities and Funding
    Host defense-stimulating macrocyclic peptides for treatment of MDR bacterial infections
    NIH/NIAID R01AI125141May 1, 2016 - Apr 30, 2021
    Role: Co-Principal Investigator
    Innate enteric immunity during induced Paneth cell deficiency
    NIH/NIAID R21AI105057Aug 15, 2013 - Jul 31, 2015
    Role: Principal Investigator
    STUDIES OF ALPHA-DEFENSINS IN PRIMATE INNATE IMMUNITY
    NIH/NIAID R01AI059346Jul 1, 2006 - Jun 30, 2012
    Role: Principal Investigator
    2005 Antimicrobial Peptides Gordon Conference
    NIH/NIAID R13AI065005Feb 1, 2005 - Jan 31, 2006
    Role: Principal Investigator
    PEPTIDE EFFECTORS OF ENTERIC HOST DEFENSE
    NIH/NIDDK R01DK044632May 1, 1993 - Apr 30, 2012
    Role: Principal Investigator
    PEPTIDE EFFECTORS OF ENTERIC HOST DEFENSE
    NIH/NIDDK R55DK044632Sep 30, 1992 - Apr 30, 1993
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Cobo ER, Holani R, Moreau F, Nakamura K, Ayabe T, Mastroianni JR, Eriguchi Y, Ouellette A, Chadee K. Correction for Cobo et al., "Entamoeba histolytica Alters Ileal Paneth Cell Functions in Intact and Muc2 Mucin Deficiency". Infect Immun. 2018 Oct; 86(10). PMID: 30242014.
      View in: PubMed
    2. Cobo ER, Holani R, Moreau F, Nakamura K, Ayabe T, Mastroianni JR, Ouellette A, Chadee K. Entamoeba histolytica Alters ileal Paneth Cell Functions in Intact and Muc2 Mucin Deficiency. Infect Immun. 2018 Apr 23. PMID: 29685982.
      View in: PubMed
    3. Patil AA, Ouellette AJ, Lu W, Zhang G. Rattusin, an intestinal a-defensin-related peptide in rats with a unique cysteine spacing pattern and salt-insensitive antibacterial activities. Antimicrob Agents Chemother. 2013 Apr; 57(4):1823-31. PMID: 23380721; PMCID: PMC3623328.
    4. Anand P, Cermelli S, Li Z, Kassan A, Bosch M, Sigua R, Huang L, Ouellette AJ, Pol A, Welte MA, Gross SP. A novel role for lipid droplets in the organismal antibacterial response. Elife. 2012 Nov 13; 1:e00003. PMID: 23150794; PMCID: PMC3491588.
    5. Ouellette AJ, Selsted ME. Immunology. HD6 defensin nanonets. Science. 2012 Jul 27; 337(6093):420-1. PMID: 22837514.
      View in: PubMed
    6. Garcia AE, Tai KP, Puttamadappa SS, Shekhtman A, Ouellette AJ, Camarero JA. Biosynthesis and antimicrobial evaluation of backbone-cyclized a-defensins. Biochemistry. 2011 Dec 06; 50(48):10508-19. PMID: 22040603; PMCID: PMC3236816.
    7. Ouellette AJ. Paneth cell a-defensins in enteric innate immunity. Cell Mol Life Sci. 2011 Jul; 68(13):2215-29. PMID: 21560070; PMCID: PMC4073591.
    8. Ouellette AJ. Paneth cells and innate mucosal immunity. Curr Opin Gastroenterol. 2010 Nov; 26(6):547-53. PMID: 20693892.
      View in: PubMed
    9. Hadjicharalambous C, Sheynis T, Jelinek R, Shanahan MT, Ouellette AJ, Gizeli E. Mechanisms of alpha-defensin bactericidal action: comparative membrane disruption by Cryptdin-4 and its disulfide-null analogue. Biochemistry. 2008 Nov 25; 47(47):12626-34. PMID: 18973303; PMCID: PMC2645939.
    10. Miszta A, Machán R, Benda A, Ouellette AJ, Hermens WT, Hof M. Combination of ellipsometry, laser scanning microscopy and Z-scan fluorescence correlation spectroscopy elucidating interaction of cryptdin-4 with supported phospholipid bilayers. J Pept Sci. 2008 Apr; 14(4):503-9. PMID: 17994618.
      View in: PubMed
    11. Tran D, Tran P, Roberts K, Osapay G, Schaal J, Ouellette A, Selsted ME. Microbicidal properties and cytocidal selectivity of rhesus macaque theta defensins. Antimicrob Agents Chemother. 2008 Mar; 52(3):944-53. PMID: 18160518; PMCID: PMC2258523.
    12. Shi J, Aono S, Lu W, Ouellette AJ, Hu X, Ji Y, Wang L, Lenz S, van Ginkel FW, Liles M, Dykstra C, Morrison EE, Elson CO. A novel role for defensins in intestinal homeostasis: regulation of IL-1beta secretion. J Immunol. 2007 Jul 15; 179(2):1245-53. PMID: 17617617.
      View in: PubMed
    13. Rosengren KJ, Daly NL, Fornander LM, Jönsson LM, Shirafuji Y, Qu X, Vogel HJ, Ouellette AJ, Craik DJ. Structural and functional characterization of the conserved salt bridge in mammalian paneth cell alpha-defensins: solution structures of mouse CRYPTDIN-4 and (E15D)-CRYPTDIN-4. J Biol Chem. 2006 Sep 22; 281(38):28068-78. PMID: 16857681.
      View in: PubMed
    14. Weeks CS, Tanabe H, Cummings JE, Crampton SP, Sheynis T, Jelinek R, Vanderlick TK, Cocco MJ, Ouellette AJ. Matrix metalloproteinase-7 activation of mouse paneth cell pro-alpha-defensins: SER43 down arrow ILE44 proteolysis enables membrane-disruptive activity. J Biol Chem. 2006 Sep 29; 281(39):28932-42. PMID: 16822871.
      View in: PubMed
    15. Ouellette AJ. Paneth cell alpha-defensins: peptide mediators of innate immunity in the small intestine. Springer Semin Immunopathol. 2005 Sep; 27(2):133-46. PMID: 15931529.
      View in: PubMed
    16. Selsted ME, Ouellette AJ. Mammalian defensins in the antimicrobial immune response. Nat Immunol. 2005 Jun; 6(6):551-7. PMID: 15908936.
      View in: PubMed
    17. Crouch ML, Becker LA, Bang IS, Tanabe H, Ouellette AJ, Fang FC. The alternative sigma factor sigma is required for resistance of Salmonella enterica serovar Typhimurium to anti-microbial peptides. Mol Microbiol. 2005 May; 56(3):789-99. PMID: 15819632.
      View in: PubMed
    18. Tanabe H, Ayabe T, Bainbridge B, Guina T, Ernst RK, Darveau RP, Miller SI, Ouellette AJ. Mouse paneth cell secretory responses to cell surface glycolipids of virulent and attenuated pathogenic bacteria. Infect Immun. 2005 Apr; 73(4):2312-20. PMID: 15784576; PMCID: PMC1087394.
    19. Jing W, Hunter HN, Tanabe H, Ouellette AJ, Vogel HJ. Solution structure of cryptdin-4, a mouse paneth cell alpha-defensin. Biochemistry. 2004 Dec 21; 43(50):15759-66. PMID: 15595831.
      View in: PubMed
    20. Tanabe H, Ouellette AJ, Cocco MJ, Robinson WE. Differential effects on human immunodeficiency virus type 1 replication by alpha-defensins with comparable bactericidal activities. J Virol. 2004 Nov; 78(21):11622-31. PMID: 15479803; PMCID: PMC523300.
    21. Maemoto A, Qu X, Rosengren KJ, Tanabe H, Henschen-Edman A, Craik DJ, Ouellette AJ. Functional analysis of the alpha-defensin disulfide array in mouse cryptdin-4. J Biol Chem. 2004 Oct 15; 279(42):44188-96. PMID: 15297466.
      View in: PubMed
    22. Ouellette AJ. Defensin-mediated innate immunity in the small intestine. Best Pract Res Clin Gastroenterol. 2004 Apr; 18(2):405-19. PMID: 15123078.
      View in: PubMed
    23. Tanabe H, Yuan J, Zaragoza MM, Dandekar S, Henschen-Edman A, Selsted ME, Ouellette AJ. Paneth cell alpha-defensins from rhesus macaque small intestine. Infect Immun. 2004 Mar; 72(3):1470-8. PMID: 14977952; PMCID: PMC356057.
    24. Lin PW, Simon PO, Gewirtz AT, Neish AS, Ouellette AJ, Madara JL, Lencer WI. Paneth cell cryptdins act in vitro as apical paracrine regulators of the innate inflammatory response. J Biol Chem. 2004 May 07; 279(19):19902-7. PMID: 14990585.
      View in: PubMed
    25. Clarke LL, Gawenis LR, Bradford EM, Judd LM, Boyle KT, Simpson JE, Shull GE, Tanabe H, Ouellette AJ, Franklin CL, Walker NM. Abnormal Paneth cell granule dissolution and compromised resistance to bacterial colonization in the intestine of CF mice. Am J Physiol Gastrointest Liver Physiol. 2004 Jun; 286(6):G1050-8. PMID: 14715526.
      View in: PubMed
    26. Tanabe H, Qu X, Weeks CS, Cummings JE, Kolusheva S, Walsh KB, Jelinek R, Vanderlick TK, Selsted ME, Ouellette AJ. Structure-activity determinants in paneth cell alpha-defensins: loss-of-function in mouse cryptdin-4 by charge-reversal at arginine residue positions. J Biol Chem. 2004 Mar 19; 279(12):11976-83. PMID: 14702345.
      View in: PubMed
    27. Satchell DP, Sheynis T, Kolusheva S, Cummings J, Vanderlick TK, Jelinek R, Selsted ME, Ouellette AJ. Quantitative interactions between cryptdin-4 amino terminal variants and membranes. Peptides. 2003 Nov; 24(11):1795-805. PMID: 15019212.
      View in: PubMed
    28. Satchell DP, Sheynis T, Shirafuji Y, Kolusheva S, Ouellette AJ, Jelinek R. Interactions of mouse Paneth cell alpha-defensins and alpha-defensin precursors with membranes. Prosegment inhibition of peptide association with biomimetic membranes. J Biol Chem. 2003 Apr 18; 278(16):13838-46. PMID: 12574157.
      View in: PubMed
    29. Shirafuji Y, Tanabe H, Satchell DP, Henschen-Edman A, Wilson CL, Ouellette AJ. Structural determinants of procryptdin recognition and cleavage by matrix metalloproteinase-7. J Biol Chem. 2003 Mar 07; 278(10):7910-9. PMID: 12482850.
      View in: PubMed
    30. Ayabe T, Satchell DP, Pesendorfer P, Tanabe H, Wilson CL, Hagen SJ, Ouellette AJ. Activation of Paneth cell alpha-defensins in mouse small intestine. J Biol Chem. 2002 Feb 15; 277(7):5219-28. PMID: 11733520.
      View in: PubMed
    31. Ayabe T, Wulff H, Darmoul D, Cahalan MD, Chandy KG, Ouellette AJ. Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, a Ca2+-activated, intermediate conductance potassium channel. J Biol Chem. 2002 Feb 01; 277(5):3793-800. PMID: 11724775.
      View in: PubMed