Andre J Ouellette, PhD
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Title(s) | Professor of Pathology |
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Address | NRT 7505 Health Sciences Campus Los Angeles CA 90089-9601
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Phone | +1 323 442 7959 |
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vCard | Download vCard |
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Research Bibliographic
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media.
(Note that publications are often cited in additional ways that are not shown here.)
Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
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Rapamycin rejuvenates oral health in aging mice. Elife. 2020 Apr 28; 9.
An JY, Kerns KA, Ouellette A, Robinson L, Morris HD, Kaczorowski C, Park SI, Mekvanich T, Kang A, McLean JS, Cox TC, Kaeberlein M. PMID: 32342860.
View in: PubMed Mentions: 4 Fields:
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Rattusin, an intestinal a-defensin-related peptide in rats with a unique cysteine spacing pattern and salt-insensitive antibacterial activities. Antimicrob Agents Chemother. 2013 Apr; 57(4):1823-31.
Patil AA, Ouellette AJ, Lu W, Zhang G. PMID: 23380721.
View in: PubMed Mentions: 4 Fields: Translation: HumansAnimalsCells
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A novel role for lipid droplets in the organismal antibacterial response. Elife. 2012 Nov 13; 1:e00003.
Anand P, Cermelli S, Li Z, Kassan A, Bosch M, Sigua R, Huang L, Ouellette AJ, Pol A, Welte MA, Gross SP. PMID: 23150794.
View in: PubMed Mentions: 37 Fields: Translation: AnimalsCells
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Immunology. HD6 defensin nanonets. Science. 2012 Jul 27; 337(6093):420-1.
Ouellette AJ, Selsted ME. PMID: 22837514.
View in: PubMed Mentions: 2 Fields: Translation: HumansAnimals
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Biosynthesis and antimicrobial evaluation of backbone-cyclized a-defensins. Biochemistry. 2011 Dec 06; 50(48):10508-19.
Garcia AE, Tai KP, Puttamadappa SS, Shekhtman A, Ouellette AJ, Camarero JA. PMID: 22040603.
View in: PubMed Mentions: 8 Fields: Translation: HumansAnimalsCells
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Paneth cell a-defensins in enteric innate immunity. Cell Mol Life Sci. 2011 Jul; 68(13):2215-29.
Ouellette AJ. PMID: 21560070.
View in: PubMed Mentions: 46 Fields: Translation: AnimalsCells
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Paneth cells and innate mucosal immunity. Curr Opin Gastroenterol. 2010 Nov; 26(6):547-53.
Ouellette AJ. PMID: 20693892.
View in: PubMed Mentions: 60 Fields: Translation: HumansAnimalsCells
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Mechanisms of alpha-defensin bactericidal action: comparative membrane disruption by Cryptdin-4 and its disulfide-null analogue. Biochemistry. 2008 Nov 25; 47(47):12626-34.
Hadjicharalambous C, Sheynis T, Jelinek R, Shanahan MT, Ouellette AJ, Gizeli E. PMID: 18973303.
View in: PubMed Mentions: 21 Fields: Translation: AnimalsCells
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Combination of ellipsometry, laser scanning microscopy and Z-scan fluorescence correlation spectroscopy elucidating interaction of cryptdin-4 with supported phospholipid bilayers. J Pept Sci. 2008 Apr; 14(4):503-9.
Miszta A, Machán R, Benda A, Ouellette AJ, Hermens WT, Hof M. PMID: 17994618.
View in: PubMed Mentions: 8 Fields:
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A novel role for defensins in intestinal homeostasis: regulation of IL-1beta secretion. J Immunol. 2007 Jul 15; 179(2):1245-53.
Shi J, Aono S, Lu W, Ouellette AJ, Hu X, Ji Y, Wang L, Lenz S, van Ginkel FW, Liles M, Dykstra C, Morrison EE, Elson CO. PMID: 17617617.
View in: PubMed Mentions: 39 Fields: Translation: HumansAnimalsCells
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Structural and functional characterization of the conserved salt bridge in mammalian paneth cell alpha-defensins: solution structures of mouse CRYPTDIN-4 and (E15D)-CRYPTDIN-4. J Biol Chem. 2006 Sep 22; 281(38):28068-78.
Rosengren KJ, Daly NL, Fornander LM, Jönsson LM, Shirafuji Y, Qu X, Vogel HJ, Ouellette AJ, Craik DJ. PMID: 16857681.
View in: PubMed Mentions: 24 Fields: Translation: HumansAnimalsCells
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Matrix metalloproteinase-7 activation of mouse paneth cell pro-alpha-defensins: SER43 down arrow ILE44 proteolysis enables membrane-disruptive activity. J Biol Chem. 2006 Sep 29; 281(39):28932-42.
Weeks CS, Tanabe H, Cummings JE, Crampton SP, Sheynis T, Jelinek R, Vanderlick TK, Cocco MJ, Ouellette AJ. PMID: 16822871.
View in: PubMed Mentions: 22 Fields: Translation: AnimalsCells
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Paneth cell alpha-defensin synthesis and function. Curr Top Microbiol Immunol. 2006; 306:1-25.
Ouellette AJ. PMID: 16909916.
View in: PubMed Mentions: 29 Fields: Translation: HumansAnimalsCells
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Paneth cell alpha-defensins: peptide mediators of innate immunity in the small intestine. Springer Semin Immunopathol. 2005 Sep; 27(2):133-46.
Ouellette AJ. PMID: 15931529.
View in: PubMed Mentions: 17 Fields: Translation: HumansAnimalsCells
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Mammalian defensins in the antimicrobial immune response. Nat Immunol. 2005 Jun; 6(6):551-7.
Selsted ME, Ouellette AJ. PMID: 15908936.
View in: PubMed Mentions: 349 Fields: Translation: HumansAnimalsCells
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The alternative sigma factor sigma is required for resistance of Salmonella enterica serovar Typhimurium to anti-microbial peptides. Mol Microbiol. 2005 May; 56(3):789-99.
Crouch ML, Becker LA, Bang IS, Tanabe H, Ouellette AJ, Fang FC. PMID: 15819632.
View in: PubMed Mentions: 28 Fields: Translation: AnimalsCells
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Mouse paneth cell secretory responses to cell surface glycolipids of virulent and attenuated pathogenic bacteria. Infect Immun. 2005 Apr; 73(4):2312-20.
Tanabe H, Ayabe T, Bainbridge B, Guina T, Ernst RK, Darveau RP, Miller SI, Ouellette AJ. PMID: 15784576.
View in: PubMed Mentions: 16 Fields: Translation: AnimalsCells
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Solution structure of cryptdin-4, a mouse paneth cell alpha-defensin. Biochemistry. 2004 Dec 21; 43(50):15759-66.
Jing W, Hunter HN, Tanabe H, Ouellette AJ, Vogel HJ. PMID: 15595831.
View in: PubMed Mentions: 15 Fields: Translation: AnimalsCells
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Differential effects on human immunodeficiency virus type 1 replication by alpha-defensins with comparable bactericidal activities. J Virol. 2004 Nov; 78(21):11622-31.
Tanabe H, Ouellette AJ, Cocco MJ, Robinson WE. PMID: 15479803.
View in: PubMed Mentions: 19 Fields: Translation: HumansCells
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Functional analysis of the alpha-defensin disulfide array in mouse cryptdin-4. J Biol Chem. 2004 Oct 15; 279(42):44188-96.
Maemoto A, Qu X, Rosengren KJ, Tanabe H, Henschen-Edman A, Craik DJ, Ouellette AJ. PMID: 15297466.
View in: PubMed Mentions: 48 Fields: Translation: AnimalsCells
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Defensin-mediated innate immunity in the small intestine. Best Pract Res Clin Gastroenterol. 2004 Apr; 18(2):405-19.
Ouellette AJ. PMID: 15123078.
View in: PubMed Mentions: 28 Fields: Translation: HumansAnimalsCells
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Paneth cell alpha-defensins from rhesus macaque small intestine. Infect Immun. 2004 Mar; 72(3):1470-8.
Tanabe H, Yuan J, Zaragoza MM, Dandekar S, Henschen-Edman A, Selsted ME, Ouellette AJ. PMID: 14977952.
View in: PubMed Mentions: 17 Fields: Translation: AnimalsCells
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Paneth cell cryptdins act in vitro as apical paracrine regulators of the innate inflammatory response. J Biol Chem. 2004 May 07; 279(19):19902-7.
Lin PW, Simon PO, Gewirtz AT, Neish AS, Ouellette AJ, Madara JL, Lencer WI. PMID: 14990585.
View in: PubMed Mentions: 14 Fields: Translation: HumansCells
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Abnormal Paneth cell granule dissolution and compromised resistance to bacterial colonization in the intestine of CF mice. Am J Physiol Gastrointest Liver Physiol. 2004 Jun; 286(6):G1050-8.
Clarke LL, Gawenis LR, Bradford EM, Judd LM, Boyle KT, Simpson JE, Shull GE, Tanabe H, Ouellette AJ, Franklin CL, Walker NM. PMID: 14715526.
View in: PubMed Mentions: 30 Fields: Translation: AnimalsCells
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Structure-activity determinants in paneth cell alpha-defensins: loss-of-function in mouse cryptdin-4 by charge-reversal at arginine residue positions. J Biol Chem. 2004 Mar 19; 279(12):11976-83.
Tanabe H, Qu X, Weeks CS, Cummings JE, Kolusheva S, Walsh KB, Jelinek R, Vanderlick TK, Selsted ME, Ouellette AJ. PMID: 14702345.
View in: PubMed Mentions: 28 Fields: Translation: AnimalsCells
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Quantitative interactions between cryptdin-4 amino terminal variants and membranes. Peptides. 2003 Nov; 24(11):1795-805.
Satchell DP, Sheynis T, Kolusheva S, Cummings J, Vanderlick TK, Jelinek R, Selsted ME, Ouellette AJ. PMID: 15019212.
View in: PubMed Mentions: 18 Fields: Translation: AnimalsCells
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Interactions of mouse Paneth cell alpha-defensins and alpha-defensin precursors with membranes. Prosegment inhibition of peptide association with biomimetic membranes. J Biol Chem. 2003 Apr 18; 278(16):13838-46.
Satchell DP, Sheynis T, Shirafuji Y, Kolusheva S, Ouellette AJ, Jelinek R. PMID: 12574157.
View in: PubMed Mentions: 37 Fields: Translation: AnimalsCells
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Structural determinants of procryptdin recognition and cleavage by matrix metalloproteinase-7. J Biol Chem. 2003 Mar 07; 278(10):7910-9.
Shirafuji Y, Tanabe H, Satchell DP, Henschen-Edman A, Wilson CL, Ouellette AJ. PMID: 12482850.
View in: PubMed Mentions: 34 Fields: Translation: AnimalsCells
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Activation of Paneth cell alpha-defensins in mouse small intestine. J Biol Chem. 2002 Feb 15; 277(7):5219-28.
Ayabe T, Satchell DP, Pesendorfer P, Tanabe H, Wilson CL, Hagen SJ, Ouellette AJ. PMID: 11733520.
View in: PubMed Mentions: 66 Fields: Translation: AnimalsCells
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Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, a Ca2+-activated, intermediate conductance potassium channel. J Biol Chem. 2002 Feb 01; 277(5):3793-800.
Ayabe T, Wulff H, Darmoul D, Cahalan MD, Chandy KG, Ouellette AJ. PMID: 11724775.
View in: PubMed Mentions: 24 Fields: Translation: HumansAnimalsCells
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Mucosal T cells regulate Paneth and intermediate cell numbers in the small intestine of T. spiralis-infected mice. Clin Exp Immunol. 2001 Oct; 126(1):117-25.
Kamal M, Wakelin D, Ouellette AJ, Smith A, Podolsky DK, Mahida YR. PMID: 11678907.
View in: PubMed Mentions: 20 Fields: Translation: AnimalsCells
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Paneth cell defensins and innate immunity of the small bowel. Inflamm Bowel Dis. 2001 Feb; 7(1):43-50.
Ouellette AJ, Bevins CL. PMID: 11233660.
View in: PubMed Mentions: 33 Fields: Translation: HumansCells
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Characterization of luminal paneth cell alpha-defensins in mouse small intestine. Attenuated antimicrobial activities of peptides with truncated amino termini. J Biol Chem. 2000 Oct 27; 275(43):33969-73.
Ouellette AJ, Satchell DP, Hsieh MM, Hagen SJ, Selsted ME. PMID: 10942762.
View in: PubMed Mentions: 20 Fields: Translation: AnimalsCells
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Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria. Nat Immunol. 2000 Aug; 1(2):113-8.
Ayabe T, Satchell DP, Wilson CL, Parks WC, Selsted ME, Ouellette AJ. PMID: 11248802.
View in: PubMed Mentions: 292 Fields: Translation: AnimalsCells
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Peptide localization and gene structure of cryptdin 4, a differentially expressed mouse paneth cell alpha-defensin. Infect Immun. 1999 Dec; 67(12):6643-51.
Ouellette AJ, Darmoul D, Tran D, Huttner KM, Yuan J, Selsted ME. PMID: 10569786.
View in: PubMed Mentions: 17 Fields: Translation: AnimalsCells
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A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins. Science. 1999 Oct 15; 286(5439):498-502.
Tang YQ, Yuan J, Osapay G, Osapay K, Tran D, Miller CJ, Ouellette AJ, Selsted ME. PMID: 10521339.
View in: PubMed Mentions: 175 Fields: Translation: HumansAnimalsCells
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Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense. Science. 1999 Oct 01; 286(5437):113-7.
Wilson CL, Ouellette AJ, Satchell DP, Ayabe T, López-Boado YS, Stratman JL, Hultgren SJ, Matrisian LM, Parks WC. PMID: 10506557.
View in: PubMed Mentions: 328 Fields: Translation: HumansAnimalsCells
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IV. Paneth cell antimicrobial peptides and the biology of the mucosal barrier. Am J Physiol. 1999 08; 277(2):G257-61.
Ouellette AJ. PMID: 10444437.
View in: PubMed Mentions: 21 Fields: Translation: HumansAnimals
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Peptide mediators of innate immunity in the small intestine. J Med Microbiol. 1998 Nov; 47(11):941-2.
Ouellette AJ. PMID: 9822294.
View in: PubMed Mentions: Fields: Translation: HumansAnimalsCells
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Paneth cells and innate immunity in the crypt microenvironment. Gastroenterology. 1997 Nov; 113(5):1779-84.
Ouellette AJ. PMID: 9352884.
View in: PubMed Mentions: 30 Fields: Translation: HumansAnimals
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Induction of epithelial chloride secretion by channel-forming cryptdins 2 and 3. Proc Natl Acad Sci U S A. 1997 Aug 05; 94(16):8585-9.
Lencer WI, Cheung G, Strohmeier GR, Currie MG, Ouellette AJ, Selsted ME, Madara JL. PMID: 9238020.
View in: PubMed Mentions: 22 Fields: Translation: HumansCells
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Cryptdin gene expression in developing mouse small intestine. Am J Physiol. 1997 Jan; 272(1 Pt 1):G197-206.
Darmoul D, Brown D, Selsted ME, Ouellette AJ. PMID: 9038894.
View in: PubMed Mentions: 21 Fields: Translation: Animals
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Paneth cell defensins: endogenous peptide components of intestinal host defense. FASEB J. 1996 Sep; 10(11):1280-9.
Ouellette AJ, Selsted ME. PMID: 8836041.
View in: PubMed Mentions: 65 Fields: Translation: HumansAnimalsCells
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Positional specificity of defensin gene expression reveals Paneth cell heterogeneity in mouse small intestine. Am J Physiol. 1996 Jul; 271(1 Pt 1):G68-74.
Darmoul D, Ouellette AJ. PMID: 8760109.
View in: PubMed Mentions: 12 Fields: Translation: AnimalsCells
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Rat neutrophil defensins. Precursor structures and expression during neutrophilic myelopoiesis. J Immunol. 1995 Nov 01; 155(9):4476-84.
Yount NY, Wang MS, Yuan J, Banaiee N, Ouellette AJ, Selsted ME. PMID: 7594610.
View in: PubMed Mentions: 20 Fields: Translation: AnimalsCells
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Defensins in granules of phagocytic and non-phagocytic cells. Trends Cell Biol. 1995 Mar; 5(3):114-9.
Selsted ME, Ouellette AJ. PMID: 14732166.
View in: PubMed Mentions: 23 Fields:
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Mouse Paneth cell defensins: primary structures and antibacterial activities of numerous cryptdin isoforms. Infect Immun. 1994 Nov; 62(11):5040-7.
Ouellette AJ, Hsieh MM, Nosek MT, Cano-Gauci DF, Huttner KM, Buick RN, Selsted ME. PMID: 7927786.
View in: PubMed Mentions: 63 Fields: Translation: AnimalsCells
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A family of defensin-like genes codes for diverse cysteine-rich peptides in mouse Paneth cells. Genomics. 1994 Nov 01; 24(1):99-109.
Huttner KM, Ouellette AJ. PMID: 7896294.
View in: PubMed Mentions: 8 Fields: Translation: AnimalsCells
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A novel gene family coding for cationic, cysteine-rich peptides. Regulation in mouse small intestine and cells of myeloid origin. J Biol Chem. 1994 Jul 15; 269(28):18702.
Ouellette AJ, Lauldi JC. PMID: 8034619.
View in: PubMed Mentions: 2 Fields: Translation: AnimalsCells
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Structure and diversity of the murine cryptdin gene family. Genomics. 1994 Feb; 19(3):448-53.
Huttner KM, Selsted ME, Ouellette AJ. PMID: 8188287.
View in: PubMed Mentions: 25 Fields: Translation: AnimalsCells
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In vitro cDNA amplification from individual intestinal crypts: a novel approach to the study of differential gene expression along the crypt-villus axis. Exp Cell Res. 1993 Oct; 208(2):344-9.
Cano-Gauci DF, Lualdi JC, Ouellette AJ, Brady G, Iscove NN, Buick RN. PMID: 7690709.
View in: PubMed Mentions: 9 Fields: Translation: AnimalsCells
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Ontogeny of Ia messenger RNA in the mouse small intestinal epithelium is modulated by age of weaning and diet. Gastroenterology. 1993 Oct; 105(4):974-80.
Sanderson IR, Ouellette AJ, Carter EA, Harmatz PR. PMID: 8405883.
View in: PubMed Mentions: 4 Fields: Translation: AnimalsCells
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Differential regulation of B7 mRNA in enterocytes and lymphoid cells. Immunology. 1993 Jul; 79(3):434-8.
Sanderson IR, Ouellette AJ, Carter EA, Walker WA, Harmatz PR. PMID: 7691725.
View in: PubMed Mentions: 10 Fields: Translation: AnimalsCells
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Kid-1, a putative renal transcription factor: regulation during ontogeny and in response to ischemia and toxic injury. Mol Cell Biol. 1993 Mar; 13(3):1933-42.
Witzgall R, O'Leary E, Gessner R, Ouellette AJ, Bonventre JV. PMID: 8382778.
View in: PubMed Mentions: 21 Fields: Translation: AnimalsCells
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Ontogeny of class II MHC mRNA in the mouse small intestinal epithelium. Mol Immunol. 1992 Oct; 29(10):1257-63.
Sanderson IR, Ouellette AJ, Carter EA, Harmatz PR. PMID: 1326714.
View in: PubMed Mentions: 3 Fields: Translation: AnimalsCells
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The defensin-related murine CRS1C gene: expression in Paneth cells and linkage to Defcr, the cryptdin locus. Genomics. 1992 Oct; 14(2):363-8.
Lin MY, Munshi IA, Ouellette AJ. PMID: 1427853.
View in: PubMed Mentions: 5 Fields: Translation: Animals
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Enteric defensins: antibiotic peptide components of intestinal host defense. J Cell Biol. 1992 Aug; 118(4):929-36.
Selsted ME, Miller SI, Henschen AH, Ouellette AJ. PMID: 1500431.
View in: PubMed Mentions: 85 Fields: Translation: AnimalsCells
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Purification and primary structure of murine cryptdin-1, a Paneth cell defensin. FEBS Lett. 1992 Jun 15; 304(2-3):146-8.
Ouellette AJ, Miller SI, Henschen AH, Selsted ME. PMID: 1618314.
View in: PubMed Mentions: 27 Fields: Translation: AnimalsCells
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Class II antigen-associated invariant chain mRNA in mouse small intestine. Biochem Biophys Res Commun. 1991 Sep 30; 179(3):1642-8.
Ouellette AJ, Frederick D, Hagen SJ, Katz JD. PMID: 1718272.
View in: PubMed Mentions: Fields: Translation: AnimalsCells
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A novel mouse gene family coding for cationic, cysteine-rich peptides. Regulation in small intestine and cells of myeloid origin. J Biol Chem. 1990 Jun 15; 265(17):9831-7.
Ouellette AJ, Lualdi JC. PMID: 2351676.
View in: PubMed Mentions: 30 Fields: Translation: AnimalsCells
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Localization of the cryptdin locus on mouse chromosome 8. Genomics. 1989 Aug; 5(2):233-9.
Ouellette AJ, Pravtcheva D, Ruddle FH, James M. PMID: 2571573.
View in: PubMed Mentions: 16 Fields: Translation: AnimalsCells
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Developmental regulation of cryptdin, a corticostatin/defensin precursor mRNA in mouse small intestinal crypt epithelium. J Cell Biol. 1989 May; 108(5):1687-95.
Ouellette AJ, Greco RM, James M, Frederick D, Naftilan J, Fallon JT. PMID: 2715173.
View in: PubMed Mentions: 67 Fields: Translation: AnimalsCells
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Accumulation of abundant messenger ribonucleic acids during postnatal development of mouse small intestine. Gastroenterology. 1988 Jan; 94(1):114-21.
Ouellette AJ, Cordell B. PMID: 3335283.
View in: PubMed Mentions: 10 Fields: Translation: AnimalsCells
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Association of poly(adenylate)-deficient messenger ribonucleic acid with membranes in mouse kidney. Biochemistry. 1981 Jun 09; 20(12):3561-7.
Ouellette AJ, Silverberg MB, Malt RA. PMID: 6114742.
View in: PubMed Mentions: 3 Fields: Translation: AnimalsCells
This graph shows the total number of publications by year. To see the data as text, click here.
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Year | Publications |
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1991 | 1 | 1992 | 4 | 1993 | 4 | 1994 | 4 | 1995 | 2 | 1996 | 2 | 1997 | 3 | 1998 | 1 | 1999 | 4 | 2000 | 2 | 2001 | 4 | 2002 | 1 | 2003 | 3 | 2004 | 7 | 2005 | 4 | 2006 | 3 | 2007 | 1 | 2008 | 2 | 2010 | 1 | 2011 | 2 | 2012 | 2 | 2013 | 1 | 2020 | 1 |
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
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