Andre J Ouellette, PhD

Title(s)Professor of Pathology
AddressNRT 7505
Health Sciences Campus
Los Angeles CA 90089-9601
Phone+1 323 442 7959
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    Collapse Research 
    Collapse Research Activities and Funding
    Host defense-stimulating macrocyclic peptides for treatment of MDR bacterial infections
    NIH R01AI125141May 1, 2016 - Apr 30, 2021
    Role: Co-Principal Investigator
    Innate enteric immunity during induced Paneth cell deficiency
    NIH R21AI105057Aug 15, 2013 - Jul 31, 2016
    Role: Principal Investigator
    STUDIES OF ALPHA-DEFENSINS IN PRIMATE INNATE IMMUNITY
    NIH R01AI059346Jul 1, 2006 - Jun 30, 2012
    Role: Principal Investigator
    2005 Antimicrobial Peptides Gordon Conference
    NIH R13AI065005Feb 1, 2005 - Jan 31, 2006
    Role: Principal Investigator
    PEPTIDE EFFECTORS OF ENTERIC HOST DEFENSE
    NIH R01DK044632May 1, 1993 - Apr 30, 2012
    Role: Principal Investigator
    PEPTIDE EFFECTORS OF ENTERIC HOST DEFENSE
    NIH R55DK044632Sep 30, 1992 - Apr 30, 1993
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Rattusin, an intestinal α-defensin-related peptide in rats with a unique cysteine spacing pattern and salt-insensitive antibacterial activities. Antimicrob Agents Chemother. 2013 Apr; 57(4):1823-31. Patil AA, Ouellette AJ, Ouellette AJ, Lu W, Zhang G. PMID: 23380721.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    2. Immunology. HD6 defensin nanonets. Science. 2012 Jul 27; 337(6093):420-1. Ouellette AJ, Selsted ME. PMID: 22837514.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    3. Biosynthesis and antimicrobial evaluation of backbone-cyclized α-defensins. Biochemistry. 2011 Dec 06; 50(48):10508-19. Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR, Garcia AE, Tai KP, Puttamadappa SS, Shekhtman A, Ouellette AJ, Ouellette AJ, Camarero JA. PMID: 22040603; PMCID: PMC3236816.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    4. Paneth cell α-defensins in enteric innate immunity. Cell Mol Life Sci. 2011 Jul; 68(13):2215-29. Ouellette AJ. PMID: 21560070.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    5. Paneth cells and innate mucosal immunity. Curr Opin Gastroenterol. 2010 Nov; 26(6):547-53. Ouellette AJ. PMID: 20693892.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    6. A novel role for defensins in intestinal homeostasis: regulation of IL-1beta secretion. J Immunol. 2007 Jul 15; 179(2):1245-53. Shi J, Aono S, Lu W, Ouellette AJ, Ouellette AJ, Hu X, Ji Y, Wang L, Lenz S, van Ginkel FW, Liles M, Dykstra C, Morrison EE, Elson CO. PMID: 17617617.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    7. Structural and functional characterization of the conserved salt bridge in mammalian paneth cell alpha-defensins: solution structures of mouse CRYPTDIN-4 and (E15D)-CRYPTDIN-4. J Biol Chem. 2006 Sep 22; 281(38):28068-78. Rosengren KJ, Daly NL, Fornander LM, Jönsson LM, Shirafuji Y, Qu X, Vogel HJ, Ouellette AJ, Ouellette AJ, Craik DJ. PMID: 16857681.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    8. Matrix metalloproteinase-7 activation of mouse paneth cell pro-alpha-defensins: SER43 down arrow ILE44 proteolysis enables membrane-disruptive activity. J Biol Chem. 2006 Sep 29; 281(39):28932-42. Weeks CS, Tanabe H, Cummings JE, Crampton SP, Sheynis T, Jelinek R, Vanderlick TK, Cocco MJ, Ouellette AJ, Ouellette AJ. PMID: 16822871.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    9. Paneth cell alpha-defensins: peptide mediators of innate immunity in the small intestine. Springer Semin Immunopathol. 2005 Sep; 27(2):133-46. Ouellette AJ, Ouellette AJ. PMID: 15931529.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    10. Mammalian defensins in the antimicrobial immune response. Nat Immunol. 2005 Jun; 6(6):551-7. Selsted ME, Ouellette AJ, Ouellette AJ. PMID: 15908936.
      View in: PubMed   Mentions: 374     Fields:    Translation:HumansAnimalsCells
    11. The alternative sigma factor sigma is required for resistance of Salmonella enterica serovar Typhimurium to anti-microbial peptides. Mol Microbiol. 2005 May; 56(3):789-99. Crouch ML, Becker LA, Bang IS, Tanabe H, Ouellette AJ, Ouellette AJ, Fang FC. PMID: 15819632.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    12. Mouse paneth cell secretory responses to cell surface glycolipids of virulent and attenuated pathogenic bacteria. Infect Immun. 2005 Apr; 73(4):2312-20. Tanabe H, Ayabe T, Bainbridge B, Guina T, Ernst RK, Darveau RP, Miller SI, Ouellette AJ, Ouellette AJ. PMID: 15784576.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    13. Solution structure of cryptdin-4, a mouse paneth cell alpha-defensin. Biochemistry. 2004 Dec 21; 43(50):15759-66. Jing W, Hunter HN, Tanabe H, Ouellette AJ, Ouellette AJ, Vogel HJ. PMID: 15595831.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    14. Differential effects on human immunodeficiency virus type 1 replication by alpha-defensins with comparable bactericidal activities. J Virol. 2004 Nov; 78(21):11622-31. Tanabe H, Ouellette AJ, Ouellette AJ, Cocco MJ, Robinson WE. PMID: 15479803.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    15. Functional analysis of the alpha-defensin disulfide array in mouse cryptdin-4. J Biol Chem. 2004 Oct 15; 279(42):44188-96. Maemoto A, Qu X, Rosengren KJ, Tanabe H, Henschen-Edman A, Craik DJ, Ouellette AJ, Ouellette AJ. PMID: 15297466.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    16. Defensin-mediated innate immunity in the small intestine. Best Pract Res Clin Gastroenterol. 2004 Apr; 18(2):405-19. Ouellette AJ, Ouellette AJ. PMID: 15123078.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    17. Paneth cell alpha-defensins from rhesus macaque small intestine. Infect Immun. 2004 Mar; 72(3):1470-8. Tanabe H, Yuan J, Zaragoza MM, Dandekar S, Henschen-Edman A, Selsted ME, Ouellette AJ, Ouellette AJ. PMID: 14977952.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    18. Paneth cell cryptdins act in vitro as apical paracrine regulators of the innate inflammatory response. J Biol Chem. 2004 May 07; 279(19):19902-7. Lin PW, Simon PO, Gewirtz AT, Neish AS, Ouellette AJ, Ouellette AJ, Madara JL, Lencer WI. PMID: 14990585.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    19. Abnormal Paneth cell granule dissolution and compromised resistance to bacterial colonization in the intestine of CF mice. Am J Physiol Gastrointest Liver Physiol. 2004 Jun; 286(6):G1050-8. Clarke LL, Gawenis LR, Bradford EM, Judd LM, Boyle KT, Simpson JE, Shull GE, Tanabe H, Ouellette AJ, Ouellette AJ, Franklin CL, Walker NM. PMID: 14715526.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    20. Structure-activity determinants in paneth cell alpha-defensins: loss-of-function in mouse cryptdin-4 by charge-reversal at arginine residue positions. J Biol Chem. 2004 Mar 19; 279(12):11976-83. Tanabe H, Qu X, Weeks CS, Cummings JE, Kolusheva S, Walsh KB, Jelinek R, Vanderlick TK, Selsted ME, Ouellette AJ, Ouellette AJ. PMID: 14702345.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    21. Quantitative interactions between cryptdin-4 amino terminal variants and membranes. Peptides. 2003 Nov; 24(11):1795-805. Satchell DP, Sheynis T, Kolusheva S, Cummings J, Vanderlick TK, Jelinek R, Selsted ME, Ouellette AJ, Ouellette AJ. PMID: 15019212.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    22. Interactions of mouse Paneth cell alpha-defensins and alpha-defensin precursors with membranes. Prosegment inhibition of peptide association with biomimetic membranes. J Biol Chem. 2003 Apr 18; 278(16):13838-46. Satchell DP, Sheynis T, Shirafuji Y, Kolusheva S, Ouellette AJ, Ouellette AJ, Jelinek R. PMID: 12574157.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    23. Structural determinants of procryptdin recognition and cleavage by matrix metalloproteinase-7. J Biol Chem. 2003 Mar 07; 278(10):7910-9. Shirafuji Y, Tanabe H, Satchell DP, Henschen-Edman A, Wilson CL, Ouellette AJ, Ouellette AJ. PMID: 12482850.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    24. Activation of Paneth cell alpha-defensins in mouse small intestine. J Biol Chem. 2002 Feb 15; 277(7):5219-28. Ayabe T, Satchell DP, Pesendorfer P, Tanabe H, Wilson CL, Hagen SJ, Ouellette AJ, Ouellette AJ. PMID: 11733520.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    25. Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, a Ca2+-activated, intermediate conductance potassium channel. J Biol Chem. 2002 Feb 01; 277(5):3793-800. Ayabe T, Wulff H, Darmoul D, Cahalan MD, Chandy KG, Ouellette AJ, Ouellette AJ. PMID: 11724775.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
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    NIH Funding Acknowledgment: Important - All publications resulting from the utilization of SC CTSI resources are required to credit the SC CTSI grant by including the NIH funding acknowledgment and must comply with the NIH Public Access Policy.

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