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Andre J Ouellette, PhD

Title(s)Professor of Pathology
Phone+1 323 442 7959
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    Collapse Research 
    Collapse Research Activities and Funding
    Host defense-stimulating macrocyclic peptides for treatment of MDR bacterial infections
    NIH/NIAID R01AI125141May 1, 2016 - Apr 30, 2021
    Role: Co-Principal Investigator
    Innate enteric immunity during induced Paneth cell deficiency
    NIH/NIAID R21AI105057Aug 15, 2013 - Jul 31, 2015
    Role: Principal Investigator
    STUDIES OF ALPHA-DEFENSINS IN PRIMATE INNATE IMMUNITY
    NIH/NIAID R01AI059346Jul 1, 2006 - Jun 30, 2012
    Role: Principal Investigator
    2005 Antimicrobial Peptides Gordon Conference
    NIH/NIAID R13AI065005Feb 1, 2005 - Jan 31, 2006
    Role: Principal Investigator
    PEPTIDE EFFECTORS OF ENTERIC HOST DEFENSE
    NIH/NIDDK R01DK044632May 1, 1993 - Apr 30, 2012
    Role: Principal Investigator
    PEPTIDE EFFECTORS OF ENTERIC HOST DEFENSE
    NIH/NIDDK R55DK044632Sep 30, 1992 - Apr 30, 1993
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Cobo ER, Holani R, Moreau F, Nakamura K, Ayabe T, Mastroianni JR, Eriguchi Y, Ouellette A, Chadee K. Correction for Cobo et al., "Entamoeba histolytica Alters Ileal Paneth Cell Functions in Intact and Muc2 Mucin Deficiency". Infect Immun. 2018 10; 86(10). PMID: 30242014.
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    2. Cobo ER, Holani R, Moreau F, Nakamura K, Ayabe T, Mastroianni JR, Eriguchi Y, Ouellette A, Chadee K. Entamoeba histolytica Alters Ileal Paneth Cell Functions in Intact and Muc2 Mucin Deficiency. Infect Immun. 2018 07; 86(7). PMID: 29685982.
      View in: PubMed
    3. Patil AA, Ouellette AJ, Lu W, Zhang G. Rattusin, an intestinal a-defensin-related peptide in rats with a unique cysteine spacing pattern and salt-insensitive antibacterial activities. Antimicrob Agents Chemother. 2013 Apr; 57(4):1823-31. PMID: 23380721.
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    4. Anand P, Cermelli S, Li Z, Kassan A, Bosch M, Sigua R, Huang L, Ouellette AJ, Pol A, Welte MA, Gross SP. A novel role for lipid droplets in the organismal antibacterial response. Elife. 2012 Nov 13; 1:e00003. PMID: 23150794.
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    5. Ouellette AJ, Selsted ME. Immunology. HD6 defensin nanonets. Science. 2012 Jul 27; 337(6093):420-1. PMID: 22837514.
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    6. Garcia AE, Tai KP, Puttamadappa SS, Shekhtman A, Ouellette AJ, Camarero JA. Biosynthesis and antimicrobial evaluation of backbone-cyclized a-defensins. Biochemistry. 2011 Dec 06; 50(48):10508-19. PMID: 22040603.
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    7. Ouellette AJ. Paneth cell a-defensins in enteric innate immunity. Cell Mol Life Sci. 2011 Jul; 68(13):2215-29. PMID: 21560070.
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    8. Ouellette AJ. Paneth cells and innate mucosal immunity. Curr Opin Gastroenterol. 2010 Nov; 26(6):547-53. PMID: 20693892.
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    9. Hadjicharalambous C, Sheynis T, Jelinek R, Shanahan MT, Ouellette AJ, Gizeli E. Mechanisms of alpha-defensin bactericidal action: comparative membrane disruption by Cryptdin-4 and its disulfide-null analogue. Biochemistry. 2008 Nov 25; 47(47):12626-34. PMID: 18973303.
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    10. Miszta A, Machán R, Benda A, Ouellette AJ, Hermens WT, Hof M. Combination of ellipsometry, laser scanning microscopy and Z-scan fluorescence correlation spectroscopy elucidating interaction of cryptdin-4 with supported phospholipid bilayers. J Pept Sci. 2008 Apr; 14(4):503-9. PMID: 17994618.
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    11. Tran D, Tran P, Roberts K, Osapay G, Schaal J, Ouellette A, Selsted ME. Microbicidal properties and cytocidal selectivity of rhesus macaque theta defensins. Antimicrob Agents Chemother. 2008 Mar; 52(3):944-53. PMID: 18160518.
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    12. Shi J, Aono S, Lu W, Ouellette AJ, Hu X, Ji Y, Wang L, Lenz S, van Ginkel FW, Liles M, Dykstra C, Morrison EE, Elson CO. A novel role for defensins in intestinal homeostasis: regulation of IL-1beta secretion. J Immunol. 2007 Jul 15; 179(2):1245-53. PMID: 17617617.
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    13. Bryant CE, Ouellette A, Lohmann K, Vandenplas M, Moore JN, Maskell DJ, Farnfield BA. The cellular Toll-like receptor 4 antagonist E5531 can act as an agonist in horse whole blood. Vet Immunol Immunopathol. 2007 Apr 15; 116(3-4):182-9. PMID: 17320193.
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    14. Rosengren KJ, Daly NL, Fornander LM, Jönsson LM, Shirafuji Y, Qu X, Vogel HJ, Ouellette AJ, Craik DJ. Structural and functional characterization of the conserved salt bridge in mammalian paneth cell alpha-defensins: solution structures of mouse CRYPTDIN-4 and (E15D)-CRYPTDIN-4. J Biol Chem. 2006 Sep 22; 281(38):28068-78. PMID: 16857681.
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    15. Weeks CS, Tanabe H, Cummings JE, Crampton SP, Sheynis T, Jelinek R, Vanderlick TK, Cocco MJ, Ouellette AJ. Matrix metalloproteinase-7 activation of mouse paneth cell pro-alpha-defensins: SER43 down arrow ILE44 proteolysis enables membrane-disruptive activity. J Biol Chem. 2006 Sep 29; 281(39):28932-42. PMID: 16822871.
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    16. Ouellette AJ. Paneth cell alpha-defensin synthesis and function. Curr Top Microbiol Immunol. 2006; 306:1-25. PMID: 16909916.
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    17. Ouellette AJ. Paneth cell alpha-defensins: peptide mediators of innate immunity in the small intestine. Springer Semin Immunopathol. 2005 Sep; 27(2):133-46. PMID: 15931529.
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    18. Selsted ME, Ouellette AJ. Mammalian defensins in the antimicrobial immune response. Nat Immunol. 2005 Jun; 6(6):551-7. PMID: 15908936.
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    19. Crouch ML, Becker LA, Bang IS, Tanabe H, Ouellette AJ, Fang FC. The alternative sigma factor sigma is required for resistance of Salmonella enterica serovar Typhimurium to anti-microbial peptides. Mol Microbiol. 2005 May; 56(3):789-99. PMID: 15819632.
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    20. Tanabe H, Ayabe T, Bainbridge B, Guina T, Ernst RK, Darveau RP, Miller SI, Ouellette AJ. Mouse paneth cell secretory responses to cell surface glycolipids of virulent and attenuated pathogenic bacteria. Infect Immun. 2005 Apr; 73(4):2312-20. PMID: 15784576; PMCID: PMC1087394.
      View in: PubMed, PubMed Central
    21. Jing W, Hunter HN, Tanabe H, Ouellette AJ, Vogel HJ. Solution structure of cryptdin-4, a mouse paneth cell alpha-defensin. Biochemistry. 2004 Dec 21; 43(50):15759-66. PMID: 15595831.
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    22. Tanabe H, Ouellette AJ, Cocco MJ, Robinson WE. Differential effects on human immunodeficiency virus type 1 replication by alpha-defensins with comparable bactericidal activities. J Virol. 2004 Nov; 78(21):11622-31. PMID: 15479803; PMCID: PMC523300.
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    23. Maemoto A, Qu X, Rosengren KJ, Tanabe H, Henschen-Edman A, Craik DJ, Ouellette AJ. Functional analysis of the alpha-defensin disulfide array in mouse cryptdin-4. J Biol Chem. 2004 Oct 15; 279(42):44188-96. PMID: 15297466.
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    24. Ouellette AJ. Defensin-mediated innate immunity in the small intestine. Best Pract Res Clin Gastroenterol. 2004 Apr; 18(2):405-19. PMID: 15123078.
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    25. Tanabe H, Yuan J, Zaragoza MM, Dandekar S, Henschen-Edman A, Selsted ME, Ouellette AJ. Paneth cell alpha-defensins from rhesus macaque small intestine. Infect Immun. 2004 Mar; 72(3):1470-8. PMID: 14977952; PMCID: PMC356057.
      View in: PubMed, PubMed Central
    26. Lin PW, Simon PO, Gewirtz AT, Neish AS, Ouellette AJ, Madara JL, Lencer WI. Paneth cell cryptdins act in vitro as apical paracrine regulators of the innate inflammatory response. J Biol Chem. 2004 May 07; 279(19):19902-7. PMID: 14990585.
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    27. Clarke LL, Gawenis LR, Bradford EM, Judd LM, Boyle KT, Simpson JE, Shull GE, Tanabe H, Ouellette AJ, Franklin CL, Walker NM. Abnormal Paneth cell granule dissolution and compromised resistance to bacterial colonization in the intestine of CF mice. Am J Physiol Gastrointest Liver Physiol. 2004 Jun; 286(6):G1050-8. PMID: 14715526.
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    28. Tanabe H, Qu X, Weeks CS, Cummings JE, Kolusheva S, Walsh KB, Jelinek R, Vanderlick TK, Selsted ME, Ouellette AJ. Structure-activity determinants in paneth cell alpha-defensins: loss-of-function in mouse cryptdin-4 by charge-reversal at arginine residue positions. J Biol Chem. 2004 Mar 19; 279(12):11976-83. PMID: 14702345.
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    29. Satchell DP, Sheynis T, Kolusheva S, Cummings J, Vanderlick TK, Jelinek R, Selsted ME, Ouellette AJ. Quantitative interactions between cryptdin-4 amino terminal variants and membranes. Peptides. 2003 Nov; 24(11):1795-805. PMID: 15019212.
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    30. Satchell DP, Sheynis T, Shirafuji Y, Kolusheva S, Ouellette AJ, Jelinek R. Interactions of mouse Paneth cell alpha-defensins and alpha-defensin precursors with membranes. Prosegment inhibition of peptide association with biomimetic membranes. J Biol Chem. 2003 Apr 18; 278(16):13838-46. PMID: 12574157.
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    31. Shirafuji Y, Tanabe H, Satchell DP, Henschen-Edman A, Wilson CL, Ouellette AJ. Structural determinants of procryptdin recognition and cleavage by matrix metalloproteinase-7. J Biol Chem. 2003 Mar 07; 278(10):7910-9. PMID: 12482850.
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    32. Ayabe T, Satchell DP, Pesendorfer P, Tanabe H, Wilson CL, Hagen SJ, Ouellette AJ. Activation of Paneth cell alpha-defensins in mouse small intestine. J Biol Chem. 2002 Feb 15; 277(7):5219-28. PMID: 11733520.
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    33. Ayabe T, Wulff H, Darmoul D, Cahalan MD, Chandy KG, Ouellette AJ. Modulation of mouse Paneth cell alpha-defensin secretion by mIKCa1, a Ca2+-activated, intermediate conductance potassium channel. J Biol Chem. 2002 Feb 01; 277(5):3793-800. PMID: 11724775.
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    34. Kamal M, Wakelin D, Ouellette AJ, Smith A, Podolsky DK, Mahida YR. Mucosal T cells regulate Paneth and intermediate cell numbers in the small intestine of T. spiralis-infected mice. Clin Exp Immunol. 2001 Oct; 126(1):117-25. PMID: 11678907.
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    35. Ouellette AJ, Bevins CL. Paneth cell defensins and innate immunity of the small bowel. Inflamm Bowel Dis. 2001 Feb; 7(1):43-50. PMID: 11233660.
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    36. Ouellette AJ, Satchell DP, Hsieh MM, Hagen SJ, Selsted ME. Characterization of luminal paneth cell alpha-defensins in mouse small intestine. Attenuated antimicrobial activities of peptides with truncated amino termini. J Biol Chem. 2000 Oct 27; 275(43):33969-73. PMID: 10942762.
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    37. Ayabe T, Satchell DP, Wilson CL, Parks WC, Selsted ME, Ouellette AJ. Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria. Nat Immunol. 2000 Aug; 1(2):113-8. PMID: 11248802.
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    38. Ouellette AJ, Darmoul D, Tran D, Huttner KM, Yuan J, Selsted ME. Peptide localization and gene structure of cryptdin 4, a differentially expressed mouse paneth cell alpha-defensin. Infect Immun. 1999 Dec; 67(12):6643-51. PMID: 10569786; PMCID: PMC97078.
      View in: PubMed, PubMed Central
    39. Tang YQ, Yuan J, Osapay G, Osapay K, Tran D, Miller CJ, Ouellette AJ, Selsted ME. A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins. Science. 1999 Oct 15; 286(5439):498-502. PMID: 10521339.
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    40. Wilson CL, Ouellette AJ, Satchell DP, Ayabe T, López-Boado YS, Stratman JL, Hultgren SJ, Matrisian LM, Parks WC. Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense. Science. 1999 Oct 01; 286(5437):113-7. PMID: 10506557.
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    41. Ouellette AJ. IV. Paneth cell antimicrobial peptides and the biology of the mucosal barrier. Am J Physiol. 1999 08; 277(2):G257-61. PMID: 10444437.
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    42. Ouellette AJ. Peptide mediators of innate immunity in the small intestine. J Med Microbiol. 1998 Nov; 47(11):941-2. PMID: 9822294.
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    43. Ouellette AJ. Paneth cells and innate immunity in the crypt microenvironment. Gastroenterology. 1997 Nov; 113(5):1779-84. PMID: 9352884.
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    44. Lencer WI, Cheung G, Strohmeier GR, Currie MG, Ouellette AJ, Selsted ME, Madara JL. Induction of epithelial chloride secretion by channel-forming cryptdins 2 and 3. Proc Natl Acad Sci U S A. 1997 Aug 05; 94(16):8585-9. PMID: 9238020; PMCID: PMC23028.
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    45. Darmoul D, Brown D, Selsted ME, Ouellette AJ. Cryptdin gene expression in developing mouse small intestine. Am J Physiol. 1997 Jan; 272(1 Pt 1):G197-206. PMID: 9038894.
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    46. Ouellette AJ, Selsted ME. Paneth cell defensins: endogenous peptide components of intestinal host defense. FASEB J. 1996 Sep; 10(11):1280-9. PMID: 8836041.
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    47. Darmoul D, Ouellette AJ. Positional specificity of defensin gene expression reveals Paneth cell heterogeneity in mouse small intestine. Am J Physiol. 1996 Jul; 271(1 Pt 1):G68-74. PMID: 8760109.
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    48. Yount NY, Wang MS, Yuan J, Banaiee N, Ouellette AJ, Selsted ME. Rat neutrophil defensins. Precursor structures and expression during neutrophilic myelopoiesis. J Immunol. 1995 Nov 01; 155(9):4476-84. PMID: 7594610.
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    49. Selsted ME, Ouellette AJ. Defensins in granules of phagocytic and non-phagocytic cells. Trends Cell Biol. 1995 Mar; 5(3):114-9. PMID: 14732166.
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    50. Ouellette AJ, Hsieh MM, Nosek MT, Cano-Gauci DF, Huttner KM, Buick RN, Selsted ME. Mouse Paneth cell defensins: primary structures and antibacterial activities of numerous cryptdin isoforms. Infect Immun. 1994 Nov; 62(11):5040-7. PMID: 7927786; PMCID: PMC303224.
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    51. Huttner KM, Ouellette AJ. A family of defensin-like genes codes for diverse cysteine-rich peptides in mouse Paneth cells. Genomics. 1994 Nov 01; 24(1):99-109. PMID: 7896294.
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    52. Bry L, Falk P, Huttner K, Ouellette A, Midtvedt T, Gordon JI. Paneth cell differentiation in the developing intestine of normal and transgenic mice. Proc Natl Acad Sci U S A. 1994 Oct 25; 91(22):10335-9. PMID: 7937951.
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    53. Ouellette AJ, Lauldi JC. A novel gene family coding for cationic, cysteine-rich peptides. Regulation in mouse small intestine and cells of myeloid origin. J Biol Chem. 1994 Jul 15; 269(28):18702. PMID: 8034619.
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    54. Huttner KM, Selsted ME, Ouellette AJ. Structure and diversity of the murine cryptdin gene family. Genomics. 1994 Feb; 19(3):448-53. PMID: 8188287.
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    55. Sanderson IR, Ouellette AJ, Carter EA, Harmatz PR. Ontogeny of Ia messenger RNA in the mouse small intestinal epithelium is modulated by age of weaning and diet. Gastroenterology. 1993 Oct; 105(4):974-80. PMID: 8405883.
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    56. Cano-Gauci DF, Lualdi JC, Ouellette AJ, Brady G, Iscove NN, Buick RN. In vitro cDNA amplification from individual intestinal crypts: a novel approach to the study of differential gene expression along the crypt-villus axis. Exp Cell Res. 1993 Oct; 208(2):344-9. PMID: 7690709.
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    57. Sanderson IR, Ouellette AJ, Carter EA, Walker WA, Harmatz PR. Differential regulation of B7 mRNA in enterocytes and lymphoid cells. Immunology. 1993 Jul; 79(3):434-8. PMID: 7691725.
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    58. Witzgall R, O'Leary E, Gessner R, Ouellette AJ, Bonventre JV. Kid-1, a putative renal transcription factor: regulation during ontogeny and in response to ischemia and toxic injury. Mol Cell Biol. 1993 Mar; 13(3):1933-42. PMID: 8382778.
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    59. Sanderson IR, Ouellette AJ, Carter EA, Harmatz PR. Ontogeny of class II MHC mRNA in the mouse small intestinal epithelium. Mol Immunol. 1992 Oct; 29(10):1257-63. PMID: 1326714.
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    60. Lin MY, Munshi IA, Ouellette AJ. The defensin-related murine CRS1C gene: expression in Paneth cells and linkage to Defcr, the cryptdin locus. Genomics. 1992 Oct; 14(2):363-8. PMID: 1427853.
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    61. Selsted ME, Miller SI, Henschen AH, Ouellette AJ. Enteric defensins: antibiotic peptide components of intestinal host defense. J Cell Biol. 1992 Aug; 118(4):929-36. PMID: 1500431; PMCID: PMC2289569.
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    62. Ouellette AJ, Miller SI, Henschen AH, Selsted ME. Purification and primary structure of murine cryptdin-1, a Paneth cell defensin. FEBS Lett. 1992 Jun 15; 304(2-3):146-8. PMID: 1618314.
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    63. Ouellette AJ, Frederick D, Hagen SJ, Katz JD. Class II antigen-associated invariant chain mRNA in mouse small intestine. Biochem Biophys Res Commun. 1991 Sep 30; 179(3):1642-8. PMID: 1718272.
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    64. Ouellette AJ, Lualdi JC. A novel mouse gene family coding for cationic, cysteine-rich peptides. Regulation in small intestine and cells of myeloid origin. J Biol Chem. 1990 Jun 15; 265(17):9831-7. PMID: 2351676.
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    65. Ouellette AJ, Pravtcheva D, Ruddle FH, James M. Localization of the cryptdin locus on mouse chromosome 8. Genomics. 1989 Aug; 5(2):233-9. PMID: 2571573.
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    66. Ouellette AJ, Greco RM, James M, Frederick D, Naftilan J, Fallon JT. Developmental regulation of cryptdin, a corticostatin/defensin precursor mRNA in mouse small intestinal crypt epithelium. J Cell Biol. 1989 May; 108(5):1687-95. PMID: 2715173.
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    67. Ouellette AJ, Cordell B. Accumulation of abundant messenger ribonucleic acids during postnatal development of mouse small intestine. Gastroenterology. 1988 Jan; 94(1):114-21. PMID: 3335283.
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    68. Ouellette AJ, Silverberg MB, Malt RA. Association of poly(adenylate)-deficient messenger ribonucleic acid with membranes in mouse kidney. Biochemistry. 1981 Jun 09; 20(12):3561-7. PMID: 6114742.
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