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Amy Renee Nelson

Title(s)Postdoctoral Scholar - Research Associate
AddressZNI 301, 1501 San Pablo Street
Health Sciences Campus
Los Angeles CA 90033
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    Brain pericyte contractility, cerebral blood flow and blood-brain barrier integrity are impaired by normal aging and Alzheimer's disease amyloid-beta and are dependent on p75NTR
    NIH/NIA K99AG058780Jul 15, 2018 - Jun 30, 2020
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline. Nature. 2020 05; 581(7806):71-76. Montagne A, Nation DA, Sagare AP, Barisano G, Sweeney MD, Chakhoyan A, Pachicano M, Joe E, Nelson AR, D'Orazio LM, Buennagel DP, Harrington MG, Benzinger TLS, Fagan AM, Ringman JM, Schneider LS, Morris JC, Reiman EM, Caselli RJ, Chui HC, Tcw J, Chen Y, Pa J, Conti PS, Law M, Toga AW, Zlokovic BV. PMID: 32376954.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Channelrhodopsin Excitation Contracts Brain Pericytes and Reduces Blood Flow in the Aging Mouse Brain in vivo. Front Aging Neurosci. 2020; 12:108. Nelson AR, Sagare MA, Wang Y, Kisler K, Zhao Z, Zlokovic BV. PMID: 32410982.
      View in: PubMed   Mentions:
    3. Alpha1-Adrenergic Receptor Mediated Long-Term Depression at CA3-CA1 Synapses Can Be Induced via Accumulation of Endogenous Norepinephrine and Is Preserved Following Noradrenergic Denervation. Front Synaptic Neurosci. 2019; 11:27. Dyer-Reaves K, Goodman AM, Nelson AR, McMahon LL. PMID: 31649525.
      View in: PubMed   Mentions:
    4. Prion Protein Antagonists Rescue Alzheimer's Amyloid-ß-Related Cognitive Deficits. Trends Mol Med. 2019 02; 25(2):74-76. Sagare AP, Sweeney MD, Nelson AR, Zhao Z, Zlokovic BV. PMID: 30661727.
      View in: PubMed   Mentions: 1     Fields:    
    5. Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction. Nat Med. 2019 02; 25(2):270-276. Nation DA, Sweeney MD, Montagne A, Sagare AP, D'Orazio LM, Pachicano M, Sepehrband F, Nelson AR, Buennagel DP, Harrington MG, Benzinger TLS, Fagan AM, Ringman JM, Schneider LS, Morris JC, Chui HC, Law M, Toga AW, Zlokovic BV. PMID: 30643288.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    6. Blood-Brain Barrier: From Physiology to Disease and Back. Physiol Rev. 2019 01 01; 99(1):21-78. Sweeney MD, Zhao Z, Montagne A, Nelson AR, Zlokovic BV. PMID: 30280653.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    7. Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons. Nat Med. 2018 03; 24(3):313-325. Shi Y, Lin S, Staats KA, Li Y, Chang WH, Hung ST, Hendricks E, Linares GR, Wang Y, Son EY, Wen X, Kisler K, Wilkinson B, Menendez L, Sugawara T, Woolwine P, Huang M, Cowan MJ, Ge B, Koutsodendris N, Sandor KP, Komberg J, Vangoor VR, Senthilkumar K, Hennes V, Seah C, Nelson AR, Cheng TY, Lee SJ, August PR, Chen JA, Wisniewski N, Hanson-Smith V, Belgard TG, Zhang A, Coba M, Grunseich C, Ward ME, van den Berg LH, Pasterkamp RJ, Trotti D, Zlokovic BV, Ichida JK. PMID: 29400714.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    8. Can adjunctive therapies augment the efficacy of endovascular thrombolysis? A potential role for activated protein C. Neuropharmacology. 2018 05 15; 134(Pt B):293-301. Amar AP, Sagare AP, Zhao Z, Wang Y, Nelson AR, Griffin JH, Zlokovic BV. PMID: 28923278.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    9. Role of clusterin in the brain vascular clearance of amyloid-ß. Proc Natl Acad Sci U S A. 2017 08 15; 114(33):8681-8682. Nelson AR, Sagare AP, Zlokovic BV. PMID: 28765369.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    10. Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease. Nat Rev Neurosci. 2017 07; 18(7):419-434. Kisler K, Nelson AR, Montagne A, Zlokovic BV. PMID: 28515434.
      View in: PubMed   Mentions: 62     Fields:    Translation:Humans
    11. Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain. Nat Neurosci. 2017 Mar; 20(3):406-416. Kisler K, Nelson AR, Rege SV, Ramanathan A, Wang Y, Ahuja A, Lazic D, Tsai PS, Zhao Z, Zhou Y, Boas DA, Sakadžic S, Zlokovic BV. PMID: 28135240.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    12. Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease. Biochim Biophys Acta. 2016 05; 1862(5):887-900. Nelson AR, Sweeney MD, Sagare AP, Zlokovic BV. PMID: 26705676.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimals
    13. Establishment and Dysfunction of the Blood-Brain Barrier. Cell. 2015 Nov 19; 163(5):1064-1078. Zhao Z, Nelson AR, Betsholtz C, Zlokovic BV. PMID: 26590417.
      View in: PubMed   Mentions: 171     Fields:    Translation:HumansAnimalsCells
    14. Impaired vascular-mediated clearance of brain amyloid beta in Alzheimer's disease: the role, regulation and restoration of LRP1. Front Aging Neurosci. 2015; 7:136. Ramanathan A, Nelson AR, Sagare AP, Zlokovic BV. PMID: 26236233.
      View in: PubMed   Mentions:
    15. GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration. Nat Neurosci. 2015 Apr; 18(4):521-530. Winkler EA, Nishida Y, Sagare AP, Rege SV, Bell RD, Perlmutter D, Sengillo JD, Hillman S, Kong P, Nelson AR, Sullivan JS, Zhao Z, Meiselman HJ, Wendy RB, Soto J, Abel ED, Makshanoff J, Zuniga E, De Vivo DC, Zlokovic BV. PMID: 25730668.
      View in: PubMed   Mentions: 79     Fields:    Translation:Animals
    16. Noradrenergic sympathetic sprouting and cholinergic reinnervation maintains non-amyloidogenic processing of AßPP. J Alzheimers Dis. 2014; 38(4):867-79. Nelson AR, Kolasa K, McMahon LL. PMID: 24081376.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    17. O-GlcNAcylation of AMPA receptor GluA2 is associated with a novel form of long-term depression at hippocampal synapses. J Neurosci. 2014 Jan 01; 34(1):10-21. Taylor EW, Wang K, Nelson AR, Bredemann TM, Fraser KB, Clinton SM, Puckett R, Marchase RB, Chatham JC, McMahon LL. PMID: 24381264.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    18. Duration of estrogen deprivation, not chronological age, prevents estrogen's ability to enhance hippocampal synaptic physiology. Proc Natl Acad Sci U S A. 2010 Nov 09; 107(45):19543-8. Smith CC, Vedder LC, Nelson AR, Bredemann TM, McMahon LL. PMID: 20974957.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    19. Combination of conditionally replicative adenovirus and standard chemotherapies shows synergistic antitumor effect in pancreatic cancer. Cancer Sci. 2009 Nov; 100(11):2181-7. Nelson AR, Davydova J, Curiel DT, Yamamoto M. PMID: 19689475.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    20. Core labeling of adenovirus with EGFP. Virology. 2006 Aug 01; 351(2):291-302. Le LP, Le HN, Nelson AR, Matthews DA, Yamamoto M, Curiel DT. PMID: 16678874.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
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