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Amy L. Ryan, PhD

Title(s)Assistant Professor of Medicine
AddressHMR 712 2011 Zonal Avenue
Off Campus
Los Angeles CA 90089
Phone+1 323 442 1833
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    Collapse Biography 
    Collapse Awards and Honors
    House of Commons2005Finalist, Britain's Top Young Researcher in Biosciences and Medicine
    American Heart Association 2009Finalist, Cournand and Comroe Young Investigator Award
    American Physiology Society2014Caroline tum Suden/Francis A. Hellebrandt Professional Opportunity Award
    British Council2017British Councils Alumni Award for Professional Achievement in the USA Finalist
    American Thoracic Society2017ATS Assembly on Respiratory Cell and Molecular Biology Carol Basbaum Award

    Collapse Overview 
    Collapse Overview
    Many of us take our lungs for granted yet they perform a function that is critical for life, respiration. Unfortunately millions of Americans suffer from one of a number of debilitating lung diseases making the subconscious action of breathing a very conscious and difficult activity. Studying human lung disease and, in particular, the way in which a lung disease develops in humans is exceptionally difficult in a dish. For me this was the challenge that became the focus of my postdoctoral research at The Salk Institute for Biological Studies – to create a reproducible and effective way to study human lung development and disease in a dish.

    My laboratory will focus on utilizing patient derived induced pluripotent stem cells (iPSC) and state-of-the-art gene editing technologies, such as CRISPR, to a) model and study mechanisms of lung disease development and b) investigate approaches for tissue regeneration and stem cell mediated repair of the airway epithelium.

    Collapse Research 
    Collapse Research Activities and Funding
    Characterization of mechanisms regulating multiciliated cell specification using patient-specific induced pluripotent stem cells.
    NIH/NHLBI R01HL139828Mar 15, 2018 - Feb 28, 2023
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Disease 2019. ERJ Open Res. 2020 Oct; 6(4). Wagner DE, Ikonomou L, Gilpin SE, Magin CM, Cruz F, Greaney A, Magnusson M, Chen YW, Davis B, Vanuytsel K, Rolandsson Enes S, Krasnodembskaya A, Lehmann M, Westergren-Thorsson G, Stegmayr J, Alsafadi HN, Hoffman ET, Weiss DJ, Ryan AL. PMID: 33123557.
      View in: PubMed   Mentions:
    2. Stem cells and lung regeneration. Am J Physiol Cell Physiol. 2020 Oct 01; 319(4):C675-C693. Parekh KR, Nawroth J, Pai A, Busch SM, Senger CN, Ryan AL. PMID: 32783658.
      View in: PubMed   Mentions:    Fields:    
    3. Protocol for Differentiation of Human iPSCs into Pulmonary Neuroendocrine Cells. STAR Protoc. 2020 Sep 18; 1(2):100068. Hor P, Ichida JK, Borok Z, Ryan AL. PMID: 33111106.
      View in: PubMed   Mentions:
    4. The D614G mutation in the SARS-CoV2 Spike protein increases infectivity in an ACE2 receptor dependent manner. bioRxiv. 2020 Jul 22. Ogawa J, Zhu W, Tonnu N, Singer O, Hunter T, Ryan AL, Pao GM. PMID: 32743569.
      View in: PubMed   Mentions:
    5. Technological advances in study of lung regenerative medicine:perspective from the 2019 Vermont lung stem cell conference. Cytotherapy. 2020 Oct; 22(10):519-520. Ikonomou L, Wagner DE, Gilpin SE, Weiss DJ, Ryan AL. PMID: 32507605.
      View in: PubMed   Mentions:    Fields:    
    6. Correcting CFTR: New Gene Editing Strategies for Rescuing CFTR Function Ex Vivo. Cell Stem Cell. 2020 04 02; 26(4):476-478. Ryan AL. PMID: 32243806.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. Derivation of induced pluripotent stem cells from ferret somatic cells. . 2020 04 01; 318(4):L671-L683. Gao J, Petraki S, Sun X, Brooks LA, Lynch TJ, Hsieh CL, Elteriefi R, Lorenzana Z, Punj V, Engelhardt JF, Parekh KR, Ryan AL. PMID: 32073882.
      View in: PubMed   Mentions:
    8. Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Diseases 2017. An Official American Thoracic Society Workshop Report. Am J Respir Cell Mol Biol. 2019 10; 61(4):429-439. Ryan AL, Ikonomou L, Atarod S, Bölükbas DA, Collins J, Freishtat R, Hawkins F, Gilpin SE, Uhl FE, Uriarte JJ, Weiss DJ, Wagner DE. PMID: 31573338.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    9. Intermittent Reprogramming: A Breath of Fresh Air for Lung Regeneration. Cell Stem Cell. 2017 12 07; 21(6):712-714. Firth AL. PMID: 29220663.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    10. The selective serotonin reuptake inhibitor dapoxetine inhibits voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells. Clin Exp Pharmacol Physiol. 2017 Apr; 44(4):480-487. Kim HS, Li H, Kim HW, Shin SE, Jung WK, Ha KS, Han ET, Hong SH, Firth AL, Choi IW, Park WS. PMID: 28058743.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    11. Selective serotonin reuptake inhibitor sertraline inhibits voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells. J Biosci. 2016 Dec; 41(4):659-666. Kim HS, Li H, Kim HW, Shin SE, Choi IW, Firth AL, Bang H, Bae YM, Park WS. PMID: 27966486.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    12. Alterations of voltage-dependent K(+) channels in the mesenteric artery during the early and chronic phases of diabetes. Clin Exp Pharmacol Physiol. 2016 09; 43(9):808-17. Hong da H, Li H, Kim HW, Kim HS, Son YK, Yang SR, Park JR, Ha KS, Han ET, Hong SH, Firth AL, Na SH, Park WS. PMID: 27218229.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    13. Y-27632, a Rho-Associated Protein Kinase Inhibitor, Inhibits Voltage-Dependent K+ Channels in Rabbit Coronary Arterial Smooth Muscle Cells. Pharmacology. 2016; 98(5-6):220-227. Li H, Shin SE, Kim HW, Kim HS, Jung WK, Ha KS, Han ET, Hong SH, Choi IW, Bae YM, Firth AL, Bang H, Park WS. PMID: 27438463.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    14. The anti-diabetic drug repaglinide induces vasorelaxation via activation of PKA and PKG in aortic smooth muscle. Vascul Pharmacol. 2016 09; 84:38-46. Kim HW, Li H, Kim HS, Shin SE, Jung WK, Ha KS, Han ET, Hong SH, Choi IW, Firth AL, Bang H, Park WS. PMID: 27435474.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    15. The class III anti-arrhythmic agent, amiodarone, inhibits voltage-dependent K(+) channels in rabbit coronary arterial smooth muscle cells. Naunyn Schmiedebergs Arch Pharmacol. 2016 Jul; 389(7):713-21. Li H, Kim HS, Kim HW, Shin SE, Jung WK, Ha KS, Han ET, Hong SH, Firth AL, Bae YM, Choi IW, Park WS. PMID: 27030392.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    16. Functional Gene Correction for Cystic Fibrosis in Lung Epithelial Cells Generated from Patient iPSCs. Cell Rep. 2015 Sep 01; 12(9):1385-90. Firth AL, Menon T, Parker GS, Qualls SJ, Lewis BM, Ke E, Dargitz CT, Wright R, Khanna A, Gage FH, Verma IM. PMID: 26299960.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansCells
    17. Lymphoid regeneration from gene-corrected SCID-X1 subject-derived iPSCs. Cell Stem Cell. 2015 Apr 02; 16(4):367-72. Menon T, Firth AL, Scripture-Adams DD, Galic Z, Qualls SJ, Gilmore WB, Ke E, Singer O, Anderson LS, Bornzin AR, Alexander IE, Zack JA, Verma IM. PMID: 25772073.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    18. W-7 inhibits voltage-dependent K(+) channels independent of calmodulin activity in rabbit coronary arterial smooth muscle cells. Eur J Pharmacol. 2015 Mar 05; 750:14-9. Li H, Choi IW, Hong DH, Son YK, Na SH, Jung WK, Firth AL, Jung ID, Park YM, Park WS. PMID: 25617796.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    19. The Effects of the Selective Serotonin Reuptake Inhibitor Fluvoxamine on Voltage-Dependent K(+) Channels in Rabbit Coronary Arterial Smooth Muscle Cells. Biol Pharm Bull. 2015; 38(8):1208-13. Hong DH, Li H, Kim HS, Kim HW, Shin SE, Jung WK, Na SH, Choi IW, Firth AL, Park WS, Kim DJ. PMID: 26235584.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    20. Generation of multiciliated cells in functional airway epithelia from human induced pluripotent stem cells. Proc Natl Acad Sci U S A. 2014 Apr 29; 111(17):E1723-30. Firth AL, Dargitz CT, Qualls SJ, Menon T, Wright R, Singer O, Gage FH, Khanna A, Verma IM. PMID: 24706852.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    21. Thrombin-mediated activation of Akt signaling contributes to pulmonary vascular remodeling in pulmonary hypertension. Physiol Rep. 2013 Dec 01; 1(7):e00190. Ogawa A, Firth AL, Ariyasu S, Yamadori I, Matsubara H, Song S, Fraidenburg DR, Yuan JX. PMID: 24744867.
      View in: PubMed   Mentions: 7     Fields:    
    22. Side-effects of protein kinase inhibitors on ion channels. J Biosci. 2013 Dec; 38(5):937-49. Son YK, Park H, Firth AL, Park WS. PMID: 24296897.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    23. Regulation of ca(2+) signaling in pulmonary hypertension. Korean J Physiol Pharmacol. 2013 Feb; 17(1):1-8. Firth AL, Won JY, Park WS. PMID: 23439762.
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    24. Human models for smooth muscle cell differentiation. Focus on "A novel in vitro model system for smooth muscle differentiation from human embryonic stem cell-derived mesenchymal cells". . 2013 Feb 15; 304(4):C287-8. Firth AL, Yuan JX. PMID: 23325406.
      View in: PubMed   Mentions:
    25. Animal models of pulmonary hypertension: Rho kinase inhibition. Prog Biophys Mol Biol. 2012 Aug; 109(3):67-75. Firth AL, Choi IW, Park WS. PMID: 22713173.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    26. "Ether-à-go-go" proliferation of iPSC-derived mesenchymal stem cells. Focus on "Regulation of cell proliferation of human induced pluripotent stem cell-derived mesenchymal stem cells via ether-à-go-go 1 (hEAG1) potassium channel". . 2012 Jul 15; 303(2):C113-4. Firth AL, Yuan JX. PMID: 22572851.
      View in: PubMed   Mentions:
    27. Identification of functional progenitor cells in the pulmonary vasculature. Pulm Circ. 2012 Jan-Mar; 2(1):84-100. Firth AL, Yuan JX. PMID: 22558524.
      View in: PubMed   Mentions:
    28. PDGF enhances store-operated Ca2+ entry by upregulating STIM1/Orai1 via activation of Akt/mTOR in human pulmonary arterial smooth muscle cells. . 2012 Jan 15; 302(2):C405-11. Ogawa A, Firth AL, Smith KA, Maliakal MV, Yuan JX. PMID: 22031597.
      View in: PubMed   Mentions:
    29. Direct effect of protein kinase C inhibitors on cardiovascular ion channels. BMB Rep. 2011 Sep; 44(9):559-65. Son YK, Hong DH, Kim DJ, Firth AL, Park WS. PMID: 21944247.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    30. Brief report: efficient generation of hematopoietic precursors and progenitors from human pluripotent stem cell lines. Stem Cells. 2011 Jul; 29(7):1158-64. Woods NB, Parker AS, Moraghebi R, Lutz MK, Firth AL, Brennand KJ, Berggren WT, Raya A, Izpisúa Belmonte JC, Gage FH, Verma IM. PMID: 21544903.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    31. Endothelial and smooth muscle cell ion channels in pulmonary vasoconstriction and vascular remodeling. Compr Physiol. 2011 Jul; 1(3):1555-602. Makino A, Firth AL, Yuan JX. PMID: 23733654.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    32. Functional ion channels in human pulmonary artery smooth muscle cells: Voltage-dependent cation channels. Pulm Circ. 2011 Jan 01; 1(1):48-71. Firth AL, Remillard CV, Platoshyn O, Fantozzi I, Ko EA, Yuan JX. PMID: 21927714.
      View in: PubMed   Mentions:
    33. Beneficial effects of adenylyl cyclase type 6 (AC6) expression persist using a catalytically inactive AC6 mutant. Mol Pharmacol. 2011 Mar; 79(3):381-8. Gao MH, Tang T, Lai NC, Miyanohara A, Guo T, Tang R, Firth AL, Yuan JX, Hammond HK. PMID: 21127130.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    34. Idiopathic pulmonary arterial hypertension. Dis Model Mech. 2010 May-Jun; 3(5-6):268-73. Firth AL, Mandel J, Yuan JX. PMID: 20427556.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimals
    35. Increased sensitivity of serotonin on the voltage-dependent K+ channels in mesenteric arterial smooth muscle cells of OLETF rats. Prog Biophys Mol Biol. 2010 Sep; 103(1):88-94. Ko EA, Park WS, Firth AL, Hong DH, Choi SW, Heo HJ, Kim MH, Noh JH, Ko JH, Kim N, Earm YE, Song DK, Han J. PMID: 20219524.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    36. Multipotent mesenchymal progenitor cells are present in endarterectomized tissues from patients with chronic thromboembolic pulmonary hypertension. . 2010 May; 298(5):C1217-25. Firth AL, Yao W, Ogawa A, Madani MM, Lin GY, Yuan JX. PMID: 20181931.
      View in: PubMed   Mentions:
    37. Upregulation of Oct-4 isoforms in pulmonary artery smooth muscle cells from patients with pulmonary arterial hypertension. . 2010 Apr; 298(4):L548-57. Firth AL, Yao W, Remillard CV, Ogawa A, Yuan JX. PMID: 20139178.
      View in: PubMed   Mentions:
    38. Patho-, physiological roles of voltage-dependent K+ channels in pulmonary arterial smooth muscle cells. J Smooth Muscle Res. 2010; 46(2):89-105. Park WS, Firth AL, Han J, Ko EA. PMID: 20551590.
      View in: PubMed   Mentions: 16     Fields:    Translation:Cells
    39. Pathophysiology of voltage-gated K+ channels in vascular smooth muscle cells: modulation by protein kinases. Prog Biophys Mol Biol. 2010 Sep; 103(1):95-101. Ko EA, Park WS, Firth AL, Kim N, Yuan JX, Han J. PMID: 19835907.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    40. Hypoxia selectively inhibits KCNA5 channels in pulmonary artery smooth muscle cells. Ann N Y Acad Sci. 2009 Oct; 1177:101-11. Firth AL, Platoshyn O, Brevnova EE, Burg ED, Powell F, Haddad GH, Yuan JX. PMID: 19845612.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    41. Inhibition of mTOR attenuates store-operated Ca2+ entry in cells from endarterectomized tissues of patients with chronic thromboembolic pulmonary hypertension. . 2009 Oct; 297(4):L666-76. Ogawa A, Firth AL, Yao W, Madani MM, Kerr KM, Auger WR, Jamieson SW, Thistlethwaite PA, Yuan JX. PMID: 19633069.
      View in: PubMed   Mentions:
    42. Chronic exposure to fibrin and fibrinogen differentially regulates intracellular Ca2+ in human pulmonary arterial smooth muscle and endothelial cells. . 2009 Jun; 296(6):L979-86. Firth AL, Yau J, White A, Chiles PG, Marsh JJ, Morris TA, Yuan JX. PMID: 19363122.
      View in: PubMed   Mentions:
    43. Identification of putative endothelial progenitor cells (CD34+CD133+Flk-1+) in endarterectomized tissue of patients with chronic thromboembolic pulmonary hypertension. . 2009 Jun; 296(6):L870-8. Yao W, Firth AL, Sacks RS, Ogawa A, Auger WR, Fedullo PF, Madani MM, Lin GY, Sakakibara N, Thistlethwaite PA, Jamieson SW, Rubin LJ, Yuan JX. PMID: 19286928.
      View in: PubMed   Mentions:
    44. Cellular localization of mitochondria contributes to Kv channel-mediated regulation of cellular excitability in pulmonary but not mesenteric circulation. . 2009 Mar; 296(3):L347-60. Firth AL, Gordienko DV, Yuill KH, Smirnov SV. PMID: 19098127.
      View in: PubMed   Mentions:
    45. Fine tuning I(CRAC): the interactions of STIM-1 and Orai. J Physiol. 2009 Jan 15; 587(1):15-6. Firth AL. PMID: 19015187.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    46. Bringing down the ROS: a new therapeutic approach for PPHN. . 2008 Dec; 295(6):L976-8. Firth AL, Yuan JX. PMID: 18931050.
      View in: PubMed   Mentions:
    47. Thrombin-mediated increases in cytosolic [Ca2+] involve different mechanisms in human pulmonary artery smooth muscle and endothelial cells. . 2008 Dec; 295(6):L1048-55. Sacks RS, Firth AL, Remillard CV, Agange N, Yau J, Ko EA, Yuan JX. PMID: 18836030.
      View in: PubMed   Mentions:
    48. Prednisolone inhibits PDGF-induced nuclear translocation of NF-kappaB in human pulmonary artery smooth muscle cells. . 2008 Oct; 295(4):L648-57. Ogawa A, Firth AL, Yao W, Rubin LJ, Yuan JX. PMID: 18708631.
      View in: PubMed   Mentions:
    49. Mitochondria-dependent regulation of Kv currents in rat pulmonary artery smooth muscle cells. . 2008 Jul; 295(1):L61-70. Firth AL, Yuill KH, Smirnov SV. PMID: 18469114.
      View in: PubMed   Mentions:
    50. Regulation of pulmonary vasoconstriction by agonists and caveolae. Exp Lung Res. 2008 May; 34(4):195-208. Schach C, Firth AL, Xu M, Remillard CV, Patel HH, Insel PA, Yuan JX. PMID: 18432456.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    51. Adenylyl cyclase type 6 deletion decreases left ventricular function via impaired calcium handling. Circulation. 2008 Jan 01; 117(1):61-9. Tang T, Gao MH, Lai NC, Firth AL, Takahashi T, Guo T, Yuan JX, Roth DM, Hammond HK. PMID: 18071070.
      View in: PubMed   Mentions: 64     Fields:    Translation:AnimalsCells
    52. Hypoxia divergently regulates production of reactive oxygen species in human pulmonary and coronary artery smooth muscle cells. . 2007 Oct; 293(4):L952-9. Wu W, Platoshyn O, Firth AL, Yuan JX. PMID: 17693484.
      View in: PubMed   Mentions:
    53. Functional characterization of voltage-gated K+ channels in mouse pulmonary artery smooth muscle cells. . 2007 Sep; 293(3):C928-37. Ko EA, Burg ED, Platoshyn O, Msefya J, Firth AL, Yuan JX. PMID: 17581857.
      View in: PubMed   Mentions:
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