Amir H. Kashani, MD, PhD

TitleAssistant Professor of Clinical Ophthalmology
InstitutionUniversity of Southern California
AddressHC4 4900 1450 San Pablo Street
Off Campus
Los Angeles CA 90033-6103
Phone+1 323 442 6578
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    Collapse Biography 
    Collapse Education and Training
    Johns Hopkins School of MedicineMD2006
    Johns Hopkins School of MedicinePhD2006
    USC Roski Eye InstituteOphthalmology Residency2010
    Associated Retinal ConsultantsVitreoretinal Surgery Fellowship2013
    Collapse Awards and Honors
    Johns Hopkins School of Medicine2000Medical Student Research Fellowship
    ARVO2006Retinal Research Foundation Grant
    1999  - 2006Medical Scientist Training Program Fellowship (MSTP)
    2007ARVO Research Travel Grant
    USC Department of Ophthalmology2008Resident Research Award
    Association for Research in Vision and Ophthalmology2009Member
    2009Henry and Lilian Nesburn Award
    2009Heed Resident Research Symposium (Rank #4)
    2012Ron G. Michel's Fellowhship
    Society of Heed Scholars2012Heed Ophthalmic Foundation Fellow
    Ocular Surgery News2016Nominated to 150 leading innovators in medical and surgical retina
    The Ophthalmologist2017Rising Stars Power List

    Collapse Overview 
    Collapse Overview
    Amir H. Kashani, MD, PhD, attended Johns Hopkins School of Medicine where he obtained both his MD and PhD in Neuroscience in 2006. He completed an internship at the Johns Hopkins Hospital in 2007 and ophthalmology residency at the USC Roski Eye Institute from 2007-2010. He then completed a fellowship in vitreoretinal surgery at the top-rated Associated Retinal Consultants in Royal Oak, Michigan. During his training, we was awarded both the Heed and Michel’s Fellowships (National Honors given on a competitive basis among all vitreoretinal trainees in the country) during his training. In his clinical practice, he treats patients with medical and surgical retinal diseases including diabetic retinopathy, retinal vein occlusions, age-related macular degeneration and retinal detachments among other common retinal diseases. He also specializes in complex retinal detachment surgeries.

    In the laboratory, Dr. Kashani is developing novel diagnostic and therapeutic methods to diagnose and treat retinal diseases. His investigates the use of advanced imaging spectroscopy and optical coherence tomography methods to improve the early detection of chronic diseases like diabetic retinopathy, retinal venous occlusion and neurodegenerative diseases such as Alzheimer’s disease. Dr. Kashani is the principal investigator for a clinical trial to test a novel stem cell therapy for severe vision loss from advanced dry age-related macular degeneration. The preliminary results of this study were published in Science Translation Medicine in April 2018. In recognition of his cutting edge research Dr. Kashani has been recognized internationally by his peers. In 2016 he was named as one of the top 150 innovators in the field of medical and surgical retina by Ocular Surgery News. In 2017 he was named as one of the top 50 "rising stars" world-wide in the field of ophthalmology by The Ophthalmologist. Dr. Kashani has co-authored more than 40 peer reviewed articles in the scientific literature, several subject reviews, and recently co-authored an ophthalmology book entitled "Optical Coherence Tomography and OCT Angiography: Clinical Reference and Case Studies." Dr. Kashani clinical work has been recognized by multiple organizations and publications including Pasadena’s Top Doctors, America’s Top Ophthalmologist, Best Doctors in America, Marquis Who’s Who in the World.

    Collapse Research 
    Collapse Research Activities and Funding
    3D OCT Angiography for quantitative characterization of diabetic retinopathy
    NIH/NEI R21EY027879Apr 1, 2017 - Mar 31, 2019
    Role: Co-Principal Investigator
    Imaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel Disease
    NIH/NINDS UH2NS100614Sep 30, 2016 - Aug 31, 2019
    Role: Co-Principal Investigator
    Functional Imaging in Hypoxic-Ischemic Retinal Disease
    NIH/NEI K08EY027006Aug 1, 2016 - Jul 31, 2021
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Required Scholarly Project Mentor

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Kashani A, Abboud G, Lo SK, Jamil LH. Double balloon enteroscopy-assisted endoscopic retrograde cholangiopancreatography in Roux-en-Y gastric bypass anatomy: expert vs. novice experience. Endosc Int Open. 2018 Jul; 6(7):E885-E891. PMID: 29978010.
      View in: PubMed
    2. Kashani A, Lebkowski JS, Rahhal FM, Avery RL, Salehi-Had H, Dang W, Lin CM, Mitra D, Zhu D, Thomas BB, Hikita ST, Pennington BO, Johnson LV, Clegg DO, Hinton DR, Humayun MS. A bioengineered retinal pigment epithelial monolayer for advanced, dry age-related macular degeneration. Sci Transl Med. 2018 Apr 04; 10(435). PMID: 29618560.
      View in: PubMed
    3. Richter GM, Madi I, Chu Z, Burkemper B, Chang R, Zaman A, Sylvester B, Reznik A, Kashani A, Wang RK, Varma R. Structural and Functional Associations of Macular Microcirculation in the Ganglion Cell-Inner Plexiform Layer in Glaucoma Using Optical Coherence Tomography Angiography. J Glaucoma. 2018 Mar; 27(3):281-290. PMID: 29394201.
      View in: PubMed
    4. Patel SR, Moysidis SN, Koulisis N, Storey PP, Kashani A, Rao NA, Rodger DC. Is it melanoma-associated retinopathy or drug toxicity? Bilateral cystoid macular edema posing a diagnostic and therapeutic dilemma. Am J Ophthalmol Case Rep. 2018 Jun; 10:77-80. PMID: 29780921.
      View in: PubMed
    5. Carpenter CL, Kim AY, Kashani A. Normative Retinal Thicknesses in Common Animal Models of Eye Disease Using Spectral Domain Optical Coherence Tomography. Adv Exp Med Biol. 2018; 1074:157-166. PMID: 29721940.
      View in: PubMed
    6. Kogachi K, Wolfe JD, Kashani A. Surgically Induced Focal Retinal Detachment Does Not Cause Detectable SD-OCT Retinal Changes in Normal Human Retina. Invest Ophthalmol Vis Sci. 2017 10 01; 58(12):5270-5279. PMID: 29049728.
      View in: PubMed
    7. Zhang Y, Kashani A, Hubbard GB. Diagnostic and Therapeutic Challenges. Retina. 2017 09; 37(9):1805-1808. PMID: 28134739.
      View in: PubMed
    8. Kashani A, Chen CL, Gahm JK, Zheng F, Richter GM, Rosenfeld PJ, Shi Y, Wang RK. Optical coherence tomography angiography: A comprehensive review of current methods and clinical applications. Prog Retin Eye Res. 2017 Sep; 60:66-100. PMID: 28760677.
      View in: PubMed
    9. Koulisis N, Kim AY, Chu Z, Shahidzadeh A, Burkemper B, Olmos de Koo LC, Moshfeghi AA, Ameri H, Puliafito CA, Isozaki VL, Wang RK, Kashani A. Quantitative microvascular analysis of retinal venous occlusions by spectral domain optical coherence tomography angiography. PLoS One. 2017; 12(4):e0176404. PMID: 28437483.
      View in: PubMed
    10. Moysidis SN, Koulisis N, Patel VR, Kashani A, Rao NA, Humayun MS, Rodger DC. THE SECOND BLIND SPOT: SMALL RETINAL VESSEL VASCULOPATHY AFTER VACCINATION AGAINST NEISSERIA MENINGITIDIS AND YELLOW FEVER. Retin Cases Brief Rep. 2017 Winter; 11 Suppl 1:S18-S23. PMID: 27599107.
      View in: PubMed
    11. Kim AY, Rodger DC, Shahidzadeh A, Chu Z, Koulisis N, Burkemper B, Jiang X, Pepple KL, Wang RK, Puliafito CA, Rao NA, Kashani A. Quantifying Retinal Microvascular Changes in Uveitis Using Spectral-Domain Optical Coherence Tomography Angiography. Am J Ophthalmol. 2016 Nov; 171:101-112. PMID: 27594138.
      View in: PubMed
    12. Kim AY, Chu Z, Shahidzadeh A, Wang RK, Puliafito CA, Kashani A. Quantifying Microvascular Density and Morphology in Diabetic Retinopathy Using Spectral-Domain Optical Coherence Tomography Angiography. Invest Ophthalmol Vis Sci. 2016 07 01; 57(9):OCT362-70. PMID: 27409494; PMCID: PMC4968771 [Available on 01/01/17].
    13. Koss MJ, Falabella P, Stefanini FR, Pfister M, Thomas BB, Kashani A, Brant R, Zhu D, Clegg DO, Hinton DR, Humayun MS. Subretinal implantation of a monolayer of human embryonic stem cell-derived retinal pigment epithelium: a feasibility and safety study in Yucatán minipigs. Graefes Arch Clin Exp Ophthalmol. 2016 Aug; 254(8):1553-65. PMID: 27335025.
      View in: PubMed
    14. Koulisis N, Moysidis SN, Olmos de Koo LC, Russell CA, Kashani A. The tipping point: Tamoxifen toxicity, central serous chorioretinopathy, and the role of estrogen and its receptors. Am J Ophthalmol Case Rep. 2016 Oct; 3:8-13. PMID: 29503899.
      View in: PubMed
    15. Kashani A. Stem Cell Therapy in Nonneovascular Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2016 Apr 01; 57(5):ORSFm1-9. PMID: 27116669.
      View in: PubMed
    16. Murali K, Kang D, Nazari H, Scianmarello N, Cadenas E, Tai YC, Kashani A, Humayun M. Spatial Variations in Vitreous Oxygen Consumption. PLoS One. 2016; 11(3):e0149961. PMID: 26930281; PMCID: PMC4773158.
    17. Kashani A, Zhang Y, Capone A, Drenser KA, Puliafito C, Moshfeghi AA, Williams GA, Trese MT. Impaired Retinal Perfusion Resulting From Vitreoretinal Traction: A Mechanism of Retinal Vascular Insufficiency. Ophthalmic Surg Lasers Imaging Retina. 2016 Mar; 47(3):1-11. PMID: 26985791.
      View in: PubMed
    18. Kashani A, Lee SY, Moshfeghi A, Durbin MK, Puliafito CA. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF RETINAL VENOUS OCCLUSION. Retina. 2015 Nov; 35(11):2323-31. PMID: 26457395.
      View in: PubMed
    19. Matsunaga DR, Yi JJ, De Koo LO, Ameri H, Puliafito CA, Kashani A. Optical Coherence Tomography Angiography of Diabetic Retinopathy in Human Subjects. Ophthalmic Surg Lasers Imaging Retina. 2015 Sep; 46(8):796-805. PMID: 26431294.
      View in: PubMed
    20. Nazari H, Zhang L, Zhu D, Chader GJ, Falabella P, Stefanini F, Rowland T, Clegg DO, Kashani A, Hinton DR, Humayun MS. Stem cell based therapies for age-related macular degeneration: The promises and the challenges. Prog Retin Eye Res. 2015 Sep; 48:1-39. PMID: 26113213.
      View in: PubMed
    21. Murali K, Kashani A, Humayun MS. Whole vitreous humor dissection for vitreodynamic analysis. J Vis Exp. 2015 May 24; (99):e52759. PMID: 26065393; PMCID: PMC4532330.
    22. Moysidis SN, Koulisis N, Ameri H, Matsunaga D, Yi J, Isozaki VL, Kashani A, Olmos de Koo LC. MULTIMODAL IMAGING OF GEOGRAPHIC AREAS OF RETINAL DARKENING. Retin Cases Brief Rep. 2015; 9(4):347-51. PMID: 26421892.
      View in: PubMed
    23. Kashani A, Cheung AY, Robinson J, Williams GA. Longitudinal optical density analysis of subretinal fluid after surgical repair of rhegmatogenous retinal detachment. Retina. 2015 Jan; 35(1):149-56. PMID: 25077533.
      View in: PubMed
    24. Matsunaga D, Yi J, Puliafito CA, Kashani A. OCT angiography in healthy human subjects. Ophthalmic Surg Lasers Imaging Retina. 2014 Nov-Dec; 45(6):510-5. PMID: 25423629.
      View in: PubMed
    25. Kashani A, Lopez Jaime GR, Saati S, Martin G, Varma R, Humayun MS. Noninvasive assessment of retinal vascular oxygen content among normal and diabetic human subjects: a study using hyperspectral computed tomographic imaging spectroscopy. Retina. 2014 Sep; 34(9):1854-60. PMID: 24732694; PMCID: PMC4145024.
    26. Kashani A, Brown KT, Chang E, Drenser KA, Capone A, Trese MT. Diversity of retinal vascular anomalies in patients with familial exudative vitreoretinopathy. Ophthalmology. 2014 Nov; 121(11):2220-7. PMID: 25005911.
      View in: PubMed
    27. Jamil LH, Kashani A, Scimeca D, Ghabril M, Gross SA, Gill KR, Hasan MK, Woodward TA, Wallace MB, Raimondo M. Can endoscopic ultrasound distinguish between mediastinal benign lymph nodes and those involved by sarcoidosis, lymphoma, or metastasis? Dig Dis Sci. 2014 Sep; 59(9):2191-8. PMID: 24801684.
      View in: PubMed
    28. Stefanini FR, Maia M, Falabella P, Pfister M, Niemeyer M, Kashani A, Humayun MS, Koss MJ. Profile of ocriplasmin and its potential in the treatment of vitreomacular adhesion. Clin Ophthalmol. 2014; 8:847-56. PMID: 24851038; PMCID: PMC4018320.
    29. Murad-Kejbou S, Kashani A, Capone A, Ruby A. Staphylococcus lugdunensis endophthalmitis after intravitreal injection: a case series. Retin Cases Brief Rep. 2014; 8(1):41-4. PMID: 25372206.
      View in: PubMed
    30. Cheung AY, Kashani A, Drenser KA. Subretinal peripapillary neovascularization associated with persistent fetal vasculature. Retin Cases Brief Rep. 2014; 8(1):83-6. PMID: 25372216.
      View in: PubMed
    31. Kashani A, Learned D, Nudleman E, Drenser KA, Capone A, Trese MT. High prevalence of peripheral retinal vascular anomalies in family members of patients with familial exudative vitreoretinopathy. Ophthalmology. 2014 Jan; 121(1):262-8. PMID: 24084499.
      View in: PubMed
    32. Kashani A, Eliott D. The emergence of Klebsiella pneumoniae endogenous endophthalmitis in the USA: basic and clinical advances. J Ophthalmic Inflamm Infect. 2013 Feb 04; 3(1):28. PMID: 23514342; PMCID: PMC3605079.
    33. Alkin Z, Kashani A, López-Jaime GR, Ruiz García H, Humayun MS, Sadda SR. Quantitative analysis of retinal structures using spectral domain optical coherence tomography in normal rabbits. Curr Eye Res. 2013 Feb; 38(2):299-304. PMID: 23373715.
      View in: PubMed
    34. Kashani A, Aaberg TM, Capone A. Vitreomacular traction as a consequence of posterior hyaloidal contraction after transpupillary thermotherapy. Am J Ophthalmol. 2013 May; 155(5):937-45. PMID: 23352339.
      View in: PubMed
    35. Jaime GR, Kashani A, Saati S, Martin G, Chader G, Humayun MS. Acute variations in retinal vascular oxygen content in a rabbit model of retinal venous occlusion. PLoS One. 2012; 7(11):e50179. PMID: 23185567; PMCID: PMC3502464.
    36. Kashani A, Kirkman E, Martin G, Humayun MS. Hyperspectral computed tomographic imaging spectroscopy of vascular oxygen gradients in the rabbit retina in vivo. PLoS One. 2011; 6(9):e24482. PMID: 21931729; PMCID: PMC3172231.
    37. Kashani A, Eliott D. Bilateral Klebsiella pneumoniae (K1 serotype) endogenous endophthalmitis as the presenting sign of disseminated infection. Ophthalmic Surg Lasers Imaging. 2011 Feb 10; 42 Online:e12-4. PMID: 21323188.
      View in: PubMed
    38. Kashani A, Zimmer-Galler IE, Shah SM, Dustin L, Do DV, Eliott D, Haller JA, Nguyen QD. Retinal thickness analysis by race, gender, and age using Stratus OCT. Am J Ophthalmol. 2010 Mar; 149(3):496-502.e1. PMID: 20042179; PMCID: PMC2826608.
    39. Kashani A, Keane PA, Dustin L, Walsh AC, Sadda SR. Quantitative subanalysis of cystoid spaces and outer nuclear layer using optical coherence tomography in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2009 Jul; 50(7):3366-73. PMID: 19168893; PMCID: PMC2908154.
    40. Kabir A, Keshvari M, Kashani A, Alavian SM. Predicting response to HBV vaccination in people with positive anti-HBc but negative HBsAg and anti-HBs. Hum Vaccin. 2008 Sep-Oct; 4(5):379-83. PMID: 18398305.
      View in: PubMed
    41. Kashani A, Qiu Z, Jurata L, Lee SK, Pfaff S, Goebbels S, Nave KA, Ghosh A. Calcium activation of the LMO4 transcription complex and its role in the patterning of thalamocortical connections. J Neurosci. 2006 Aug 09; 26(32):8398-408. PMID: 16899735.
      View in: PubMed
    42. Kim PM, Aizawa H, Kim PS, Huang AS, Wickramasinghe SR, Kashani A, Barrow RK, Huganir RL, Ghosh A, Snyder SH. Serine racemase: activation by glutamate neurotransmission via glutamate receptor interacting protein and mediation of neuronal migration. Proc Natl Acad Sci U S A. 2005 Feb 08; 102(6):2105-10. PMID: 15684087; PMCID: PMC548584.
    43. Grinnell AD, Chen BM, Kashani A, Lin J, Suzuki K, Kidokoro Y. The role of integrins in the modulation of neurotransmitter release from motor nerve terminals by stretch and hypertonicity. J Neurocytol. 2003 Jun-Sep; 32(5-8):489-503. PMID: 15034249.
      View in: PubMed
    44. Redmond L, Kashani A, Ghosh A. Calcium regulation of dendritic growth via CaM kinase IV and CREB-mediated transcription. Neuron. 2002 Jun 13; 34(6):999-1010. PMID: 12086646.
      View in: PubMed
    45. Yaghmai R, Kashani A, Geraghty MT, Okoh J, Pomper M, Tangerman A, Wagner C, Stabler SP, Allen RH, Mudd SH, Braverman N. Progressive cerebral edema associated with high methionine levels and betaine therapy in a patient with cystathionine beta-synthase (CBS) deficiency. Am J Med Genet. 2002 Feb 15; 108(1):57-63. PMID: 11857551.
      View in: PubMed