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Ambrose Yaw-Shong Jong, PhD

TitleAssociate Professor of Pediatrics
InstitutionUniversity of Southern California
DepartmentPediatrics
AddressCHLA 4650 W. Sunset Blvd.
Off Campus
Los Angeles CA 90026
Phone+1 323 361 5647
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    Collapse Research 
    Collapse Research Activities and Funding
    Invasion of C. neoformans into brain endothelial cells
    NIH/NINDS R01NS047599Jan 1, 2004 - Jun 30, 2014
    Role: Principal Investigator
    Invasion of C. neoformans into brain endothelial cells
    NIH/NINDS R56NS047599Jan 1, 2004 - Jul 16, 2009
    Role: Principal Investigator
    YEAST CDC6 GENE CELL CYCLE PROGRESSION
    NIH/NIGMS R01GM048492Aug 1, 1993 - Jul 31, 1998
    Role: Principal Investigator
    YEAST NUCLEOSIDE DIPHOSPHATE KINASES
    NIH/NIGMS R01GM039436Apr 1, 1989 - Jun 30, 2000
    Role: Principal Investigator
    MECHANISM OF ACTION OF YEAST CDC8 PROTEIN IN DNA REPLICA
    NIH/NIGMS R29GM039436Apr 1, 1989 - Mar 31, 1994
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Required Scholarly Project Mentor

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Wen C, Seeger RC, Fabbri M, Wang L, Wayne AS, Jong A. Biological roles and potential applications of immune cell-derived extracellular vesicles. J Extracell Vesicles. 2017; 6(1):1400370. PMID: 29209467.
      View in: PubMed
    2. Jong A, Wu CH, Li J, Sun J, Fabbri M, Wayne AS, Seeger RC. Large-scale isolation and cytotoxicity of extracellular vesicles derived from activated human natural killer cells. J Extracell Vesicles. 2017; 6(1):1294368. PMID: 28326171.
      View in: PubMed
    3. Liu L, Yu J, Li L, Zhang B, Liu L, Wu CH, Jong A, Mao DA, Huang SH. Alpha7 nicotinic acetylcholine receptor is required for amyloid pathology in brain endothelial cells induced by Glycoprotein 120, methamphetamine and nicotine. Sci Rep. 2017 Jan 11; 7:40467. PMID: 28074940.
      View in: PubMed
    4. Yang ZW, Jiang YH, Ma C, Silvestri G, Bosinger SE, Li BL, Jong A, Zhou YH, Huang SH. Coexpression Network Analysis of Benign and Malignant Phenotypes of SIV-Infected Sooty Mangabey and Rhesus Macaque. PLoS One. 2016; 11(6):e0156170. PMID: 27280726; PMCID: PMC4900581.
    5. Li J, Chang YC, Wu CH, Liu J, Kwon-Chung KJ, Huang SH, Shimada H, Fante R, Fu X, Jong A. The 14-3-3 Gene Function of Cryptococcus neoformans Is Required for its Growth and Virulence. J Microbiol Biotechnol. 2016 May 28; 26(5):918-27. PMID: 26437944.
      View in: PubMed
    6. Wang S, Peng L, Gai Z, Zhang L, Jong A, Cao H, Huang SH. Pathogenic Triad in Bacterial Meningitis: Pathogen Invasion, NF-?B Activation, and Leukocyte Transmigration that Occur at the Blood-Brain Barrier. Front Microbiol. 2016; 7:148. PMID: 26925035; PMCID: PMC4760054.
    7. Tseng HK, Huang TY, Wu AY, Chen HH, Liu CP, Jong A. How Cryptococcus interacts with the blood-brain barrier. Future Microbiol. 2015; 10(10):1669-82. PMID: 26437710.
      View in: PubMed
    8. Zhang B, Yu JY, Liu LQ, Peng L, Chi F, Wu CH, Jong A, Wang SF, Cao H, Huang SH. Alpha7 nicotinic acetylcholine receptor is required for blood-brain barrier injury-related CNS disorders caused by Cryptococcus neoformans and HIV-1 associated comorbidity factors. BMC Infect Dis. 2015 Aug 19; 15:352. PMID: 26285576; PMCID: PMC4543465.
    9. Challagundla KB, Wise PM, Neviani P, Chava H, Murtadha M, Xu T, Kennedy R, Ivan C, Zhang X, Vannini I, Fanini F, Amadori D, Calin GA, Hadjidaniel M, Shimada H, Jong A, Seeger RC, Asgharzadeh S, Goldkorn A, Fabbri M. Exosome-mediated transfer of microRNAs within the tumor microenvironment and neuroblastoma resistance to chemotherapy. J Natl Cancer Inst. 2015 Jul; 107(7). PMID: 25972604; PMCID: PMC4651042.
    10. Singh A, Panting RJ, Varma A, Saijo T, Waldron KJ, Jong A, Ngamskulrungroj P, Chang YC, Rutherford JC, Kwon-Chung KJ. Factors required for activation of urease as a virulence determinant in Cryptococcus neoformans. MBio. 2013 May 07; 4(3):e00220-13. PMID: 23653445; PMCID: PMC3663189.
    11. Huang SH, Wang L, Chi F, Wu CH, Cao H, Zhang A, Jong A. Circulating brain microvascular endothelial cells (cBMECs) as potential biomarkers of the blood-brain barrier disorders caused by microbial and non-microbial factors. PLoS One. 2013; 8(4):e62164. PMID: 23637989; PMCID: PMC3637435.
    12. Huang SH, Wu CH, Chang YC, Kwon-Chung KJ, Brown RJ, Jong A. Cryptococcus neoformans-derived microvesicles enhance the pathogenesis of fungal brain infection. PLoS One. 2012; 7(11):e48570. PMID: 23144903; PMCID: PMC3492498.
    13. Tseng HK, Liu CP, Price MS, Jong A, Chang JC, Toffaletti DL, Betancourt-Quiroz M, Frazzitta AE, Cho WL, Perfect JR. Identification of genes from the fungal pathogen Cryptococcus neoformans related to transmigration into the central nervous system. PLoS One. 2012; 7(9):e45083. PMID: 23028773; PMCID: PMC3447876.
    14. Chi F, Bo T, Wu CH, Jong A, Huang SH. Vimentin and PSF act in concert to regulate IbeA+ E. coli K1 induced activation and nuclear translocation of NF-?B in human brain endothelial cells. PLoS One. 2012; 7(4):e35862. PMID: 22536447; PMCID: PMC3334993.
    15. Yang CS, Rodgers M, Min CK, Lee JS, Kingeter L, Lee JY, Jong A, Kramnik I, Lin X, Jung JU. The autophagy regulator Rubicon is a feedback inhibitor of CARD9-mediated host innate immunity. Cell Host Microbe. 2012 Mar 15; 11(3):277-89. PMID: 22423967; PMCID: PMC3615900.
    16. Jong A, Wu CH, Gonzales-Gomez I, Kwon-Chung KJ, Chang YC, Tseng HK, Cho WL, Huang SH. Hyaluronic acid receptor CD44 deficiency is associated with decreased Cryptococcus neoformans brain infection. J Biol Chem. 2012 May 04; 287(19):15298-306. PMID: 22418440; PMCID: PMC3346080.
    17. Long M, Huang SH, Wu CH, Shackleford GM, Jong A. Lipid raft/caveolae signaling is required for Cryptococcus neoformans invasion into human brain microvascular endothelial cells. J Biomed Sci. 2012 Feb 08; 19:19. PMID: 22316086; PMCID: PMC3308189.
    18. Chaudhry P, Yang X, Wagner M, Jong A, Wu L. Retinoid-regulated FGF8f secretion by osteoblasts bypasses retinoid stimuli to mediate granulocytic differentiation of myeloid leukemia cells. Mol Cancer Ther. 2012 Feb; 11(2):267-76. PMID: 22135230; PMCID: PMC3277667.
    19. Chi F, Wang L, Zheng X, Wu CH, Jong A, Sheard MA, Shi W, Huang SH. Meningitic Escherichia coli K1 penetration and neutrophil transmigration across the blood-brain barrier are modulated by alpha7 nicotinic receptor. PLoS One. 2011; 6(9):e25016. PMID: 21966399; PMCID: PMC3178609.
    20. Huang SH, Wu CH, Jiang S, Bahner I, Lossinsky AS, Jong A. HIV-1 gp41 ectodomain enhances Cryptococcus neoformans binding to human brain microvascular endothelial cells via gp41 core-induced membrane activities. Biochem J. 2011 Sep 15; 438(3):457-66. PMID: 21668410.
      View in: PubMed
    21. Chi F, Wang L, Zheng X, Jong A, Huang SH. Recruitment of a7 nicotinic acetylcholine receptor to caveolin-1-enriched lipid rafts is required for nicotine-enhanced Escherichia coli K1 entry into brain endothelial cells. Future Microbiol. 2011 Aug; 6(8):953-66. PMID: 21861625.
      View in: PubMed
    22. Huang SH, Long M, Wu CH, Kwon-Chung KJ, Chang YC, Chi F, Lee S, Jong A. Invasion of Cryptococcus neoformans into human brain microvascular endothelial cells is mediated through the lipid rafts-endocytic pathway via the dual specificity tyrosine phosphorylation-regulated kinase 3 (DYRK3). J Biol Chem. 2011 Oct 07; 286(40):34761-9. PMID: 21693704; PMCID: PMC3186382.
    23. Wang LI, Lin YS, Liu KH, Jong A, Shen WC. Cryptococcus neoformans mediator protein Ssn8 negatively regulates diverse physiological processes and is required for virulence. PLoS One. 2011 Apr 29; 6(4):e19162. PMID: 21559476; PMCID: PMC3084776.
    24. LONG M, CAO H, Jong A. [Effect of HIV-1gp41 ectodomain on Cryptococcus neoformans-induced cytoskeletal changes in human brain microvascular endothelial cells]. Nan Fang Yi Ke Da Xue Xue Bao. 2011 Mar; 31(3):478-81. PMID: 21421487.
      View in: PubMed
    25. Wang A, Alimova IN, Luo P, Jong A, Triche TJ, Wu L. Loss of CAK phosphorylation of RAR{alpha} mediates transcriptional control of retinoid-induced cancer cell differentiation. FASEB J. 2010 Mar; 24(3):833-43. PMID: 19917671; PMCID: PMC2830139.
    26. Huang SH, Jong A. Evolving role of laminin receptors in microbial pathogenesis and therapeutics of CNS infection. Future Microbiol. 2009 Oct; 4(8):959-62. PMID: 19824788.
      View in: PubMed
    27. Chi F, Wang Y, Gallaher TK, Wu CH, Jong A, Huang SH. Identification of IbeR as a stationary-phase regulator in meningitic Escherichia coli K1 that carries a loss-of-function mutation in rpoS. J Biomed Biotechnol. 2009; 2009:520283. PMID: 19300523; PMCID: PMC2655632.
    28. Huang SH, He L, Zhou Y, Wu CH, Jong A. Lactobacillus rhamnosus GG Suppresses Meningitic E. coli K1 Penetration across Human Intestinal Epithelial Cells In Vitro and Protects Neonatal Rats against Experimental Hematogenous Meningitis. Int J Microbiol. 2009; 2009:647862. PMID: 20016677; PMCID: PMC2775688.
    29. Jong A, Wu CH, Prasadarao NV, Kwon-Chung KJ, Chang YC, Ouyang Y, Shackleford GM, Huang SH. Invasion of Cryptococcus neoformans into human brain microvascular endothelial cells requires protein kinase C-alpha activation. Cell Microbiol. 2008 Sep; 10(9):1854-65. PMID: 18489726.
      View in: PubMed
    30. Feng L, Barnhart JR, Seeger RC, Wu L, Keshelava N, Huang SH, Jong A. Cdc6 knockdown inhibits human neuroblastoma cell proliferation. Mol Cell Biochem. 2008 Apr; 311(1-2):189-97. PMID: 18259842.
      View in: PubMed
    31. Jong A, Wu CH, Shackleford GM, Kwon-Chung KJ, Chang YC, Chen HM, Ouyang Y, Huang SH. Involvement of human CD44 during Cryptococcus neoformans infection of brain microvascular endothelial cells. Cell Microbiol. 2008 Jun; 10(6):1313-26. PMID: 18248627.
      View in: PubMed
    32. Jong A, Wu CH, Zhou W, Chen HM, Huang SH. Infectomic analysis of gene expression profiles of human brain microvascular endothelial cells infected with Cryptococcus neoformans. J Biomed Biotechnol. 2008; 2008:375620. PMID: 18309373; PMCID: PMC2248231.
    33. Zou Y, He L, Chi F, Jong A, Huang SH. Involvement of Escherichia coli K1 ibeT in bacterial adhesion that is associated with the entry into human brain microvascular endothelial cells. Med Microbiol Immunol. 2008 Dec; 197(4):337-44. PMID: 18040715.
      View in: PubMed
    34. Huang SH, Wang X, Jong A. The evolving role of infectomics in drug discovery. Expert Opin Drug Discov. 2007 Jul; 2(7):961-75. PMID: 23484816.
      View in: PubMed
    35. Jong A, Wu CH, Chen HM, Luo F, Kwon-Chung KJ, Chang YC, Lamunyon CW, Plaas A, Huang SH. Identification and characterization of CPS1 as a hyaluronic acid synthase contributing to the pathogenesis of Cryptococcus neoformans infection. Eukaryot Cell. 2007 Aug; 6(8):1486-96. PMID: 17545316; PMCID: PMC1951127.
    36. Jong A, Wu CH, Jiang S, Feng L, Chen HM, Huang SH. HIV-1 gp41 ectodomain enhances Cryptococcus neoformans binding to HBMEC. Biochem Biophys Res Commun. 2007 May 18; 356(4):899-905. PMID: 17400192.
      View in: PubMed
    37. Zou Y, He L, Wu CH, Cao H, Xie ZH, Ouyang Y, Wang Y, Jong A, Huang SH. PSF is an IbeA-binding protein contributing to meningitic Escherichia coli K1 invasion of human brain microvascular endothelial cells. Med Microbiol Immunol. 2007 Sep; 196(3):135-43. PMID: 17318576.
      View in: PubMed
    38. Bao GC, Wang JG, Jong A. Increased p21 expression and complex formation with cyclin E/CDK2 in retinoid-induced pre-B lymphoma cell apoptosis. FEBS Lett. 2006 Jun 26; 580(15):3687-93. PMID: 16765349.
      View in: PubMed
    39. Oh YS, Jong A, Kim DT, Li H, Wang C, Zemljic-Harpf A, Ross RS, Fishbein MC, Chen PS, Chen LS. Spatial distribution of nerve sprouting after myocardial infarction in mice. Heart Rhythm. 2006 Jun; 3(6):728-36. PMID: 16731479.
      View in: PubMed
    40. Luo F, Yee JK, Huang SH, Wu LT, Jong A. Downregulation of human Cdc6 protein using a lentivirus RNA interference expression vector. Methods Mol Biol. 2006; 342:287-93. PMID: 16957383.
      View in: PubMed
    41. Jong A, Huang SH. Blood-brain barrier drug discovery for central nervous system infections. Curr Drug Targets Infect Disord. 2005 Mar; 5(1):65-72. PMID: 15777199.
      View in: PubMed
    42. Chen SH, Stins MF, Huang SH, Chen YH, Kwon-Chung KJ, Chang Y, Kim KS, Suzuki K, Jong A. Cryptococcus neoformans induces alterations in the cytoskeleton of human brain microvascular endothelial cells. J Med Microbiol. 2003 Nov; 52(Pt 11):961-70. PMID: 14532340.
      View in: PubMed
    43. Jong A, Chen SH, Stins MF, Kim KS, Tuan TL, Huang SH. Binding of Candida albicans enolase to plasmin(ogen) results in enhanced invasion of human brain microvascular endothelial cells. J Med Microbiol. 2003 Aug; 52(Pt 8):615-22. PMID: 12867553.
      View in: PubMed
    44. Qiu W, David D, Zhou B, Chu PG, Zhang B, Wu M, Xiao J, Han T, Zhu Z, Wang T, Liu X, Lopez R, Frankel P, Jong A, Yen Y. Down-regulation of growth arrest DNA damage-inducible gene 45beta expression is associated with human hepatocellular carcinoma. Am J Pathol. 2003 Jun; 162(6):1961-74. PMID: 12759252; PMCID: PMC1868146.
    45. Huang SH, Chen SH, Jong A. Use of inverse PCR to clone cDNA ends. Methods Mol Biol. 2003; 221:51-8. PMID: 12703733.
      View in: PubMed
    46. Wang J, Barsky LW, Shum CH, Jong A, Weinberg KI, Collins SJ, Triche TJ, Wu L. Retinoid-induced G1 arrest and differentiation activation are associated with a switch to cyclin-dependent kinase-activating kinase hypophosphorylation of retinoic acid receptor alpha. J Biol Chem. 2002 Nov 08; 277(45):43369-76. PMID: 12213824.
      View in: PubMed
    47. Chen YH, Chen SH, Jong A, Zhou ZY, Li W, Suzuki K, Huang SH. Enhanced Escherichia coli invasion of human brain microvascular endothelial cells is associated with alternations in cytoskeleton induced by nicotine. Cell Microbiol. 2002 Aug; 4(8):503-14. PMID: 12174085.
      View in: PubMed
    48. Huang SH, Triche T, Jong A. Infectomics: genomics and proteomics of microbial infections. Funct Integr Genomics. 2002 Apr; 1(6):331-44. PMID: 11957108.
      View in: PubMed
    49. Huang SH, Wu HY, Jong A. Gene cloning and expression profiling by rapid amplification of gene inserts with universal vector primers. Methods Mol Biol. 2002; 192:309-14. PMID: 12494662.
      View in: PubMed
    50. Jong A, T'ang A, Liu DP, Huang SH. Inverse PCR. Genomic DNA cloning. Methods Mol Biol. 2002; 192:301-7. PMID: 12494661.
      View in: PubMed
    51. Jong A, Stins MF, Huang SH, Chen SH, Kim KS. Traversal of Candida albicans across human blood-brain barrier in vitro. Infect Immun. 2001 Jul; 69(7):4536-44. PMID: 11401997; PMCID: PMC98530.