Allison Knoll

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Title	Assistant Professor of Research Pediatrics
School	Keck School of Medicine of USC
Department	Pediatrics
Address	4640 West Sunset Boulevard Off Campus Los Angeles California 90027
Phone	+1 323 442 2776
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Overview

My research focuses on understanding the genetic and environmental basis of individual differences in typical social behavior and in risk for neurodevelopmental disorders (NDDs). We model genetic diversity using large families of recombinant inbred mouse strains in which genetic variation is extensive, fixed, and well-characterized. Current studies focus on 1) identifying genes that underlie strain differences in sociability and cognition using quantitative trait locus mapping and advanced gene validation strategies, 2) examining the interaction between genetic background and common genetic risk variants for autism spectrum disorder (ASD) to identify the biological mechanisms underlying disorder risk/resilience, and 3) identifying the role of strain genetics in moderating risk/resilience to adverse outcomes associated with early-life stress. The goal of these studies is to understand the biology of heritable variation in sociability and cognition and to advance precision medicine approaches for the treatment of NDDs and early-adversity.

Biography

Education and Training

Harvard University, Cambridge, MA

PhD

05/2010

Neurobiology

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.

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Van Segbroeck M, Knoll A, Levitt P, Narayanan S. MUPET-Mouse Ultrasonic Profile ExTraction: A Signal Processing Tool for Rapid and Unsupervised Analysis of Ultrasonic Vocalizations. Neuron. 2017 May 03; 94(3):465-485.e5. PMID: 28472651.

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Knoll A, Halladay LR, Holmes AJ, Levitt P. Quantitative Trait Loci and a Novel Genetic Candidate for Fear Learning. J Neurosci. 2016 Jun 08; 36(23):6258-68. PMID: 27277803; PMCID: PMC4899527 [Available on 12/08/16].

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Wood RI, Knoll A, Levitt P. Social housing conditions and oxytocin and vasopressin receptors contribute to ethanol conditioned social preference in female mice. Physiol Behav. 2015 Nov 01; 151:469-77. PMID: 26282397; PMCID: PMC4587335 [Available on 11/01/16].

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Dow AL, Lin TV, Chartoff EH, Potter D, McPhie DL, Van't Veer AV, Knoll A, Lee KN, Neve RL, Patel TB, Ongur D, Cohen BM, Carlezon WA. Sprouty2 in the dorsal hippocampus regulates neurogenesis and stress responsiveness in rats. PLoS One. 2015; 10(3):e0120693. PMID: 25822989; PMCID: PMC4378921.

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Knoll A, Muschamp JW, Sillivan SE, Ferguson D, Dietz DM, Meloni EG, Carroll FI, Nestler EJ, Konradi C, Carlezon WA. Kappa opioid receptor signaling in the basolateral amygdala regulates conditioned fear and anxiety in rats. Biol Psychiatry. 2011 Sep 01; 70(5):425-33. PMID: 21531393; PMCID: PMC3150294.

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Knoll A, Carlezon WA. Dynorphin, stress, and depression. Brain Res. 2010 Feb 16; 1314:56-73. PMID: 19782055; PMCID: PMC2819644.

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Carlezon WA, Béguin C, Knoll A, Cohen BM. Kappa-opioid ligands in the study and treatment of mood disorders. Pharmacol Ther. 2009 Sep; 123(3):334-43. PMID: 19497337; PMCID: PMC2740476.

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Knoll A, Meloni EG, Thomas JB, Carroll FI, Carlezon WA. Anxiolytic-like effects of kappa-opioid receptor antagonists in models of unlearned and learned fear in rats. J Pharmacol Exp Ther. 2007 Dec; 323(3):838-45. PMID: 17823306.

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Meloni EG, Gerety LP, Knoll A, Cohen BM, Carlezon WA. Behavioral and anatomical interactions between dopamine and corticotropin-releasing factor in the rat. J Neurosci. 2006 Apr 05; 26(14):3855-63. PMID: 16597740.

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