 Allison Knoll
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| Title(s) | Assistant Professor Of Research Pediatrics |
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| Address | 4640 West Sunset Boulevard
Off Campus
Los Angeles CA 90027
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| Phone | +1 323 442 2776 |
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| vCard | Download vCard |
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 Biography | Harvard University, Cambridge, MA | PhD | 05/2010 | Neurobiology |
Overview My research focuses on understanding the genetic and environmental basis of individual differences in typical social behavior and in risk for neurodevelopmental disorders (NDDs). We model genetic diversity using large families of recombinant inbred mouse strains in which genetic variation is extensive, fixed, and well-characterized. Current studies focus on 1) identifying genes that underlie strain differences in sociability and cognition using quantitative trait locus mapping and advanced gene validation strategies, 2) examining the interaction between genetic background and common genetic risk variants for autism spectrum disorder (ASD) to identify the biological mechanisms underlying disorder risk/resilience, and 3) identifying the role of strain genetics in moderating risk/resilience to adverse outcomes associated with early-life stress. The goal of these studies is to understand the biology of heritable variation in sociability and cognition and to advance precision medicine approaches for the treatment of NDDs and early-adversity.
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Gaps in Current Autism Research: The Thoughts of the Autism Research Editorial Board and Associate Editors. Autism Res. 2019 05; 12(5):700-714.
Amaral DG, Anderson GM, Bailey A, Bernier R, Bishop S, Blatt G, Canal-Bedia R, Charman T, Dawson G, de Vries PJ, Dicicco-Bloom E, Dissanayake C, Kamio Y, Kana R, Khan NZ, Knoll A, Kooy F, Lainhart J, Levitt P, Loveland K, Minshew N, Mueller RA, Murphy D, Mundy P, Palencia S, Pinto-Martin J, Rattazzi A, Rogers S, Stone WL, Webb SJ, Whitehouse A. PMID: 31025542.
View in: PubMed Mentions: Fields:
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MUPET-Mouse Ultrasonic Profile ExTraction: A Signal Processing Tool for Rapid and Unsupervised Analysis of Ultrasonic Vocalizations. Neuron. 2017 May 03; 94(3):465-485.e5.
Van Segbroeck M, Knoll AT, Levitt P, Narayanan S. PMID: 28472651.
View in: PubMed Mentions: 9 Fields: Translation: Animals
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Quantitative Trait Loci and a Novel Genetic Candidate for Fear Learning. J Neurosci. 2016 06 08; 36(23):6258-68.
Knoll AT, Halladay LR, Holmes AJ, Levitt P. PMID: 27277803.
View in: PubMed Mentions: 2 Fields: Translation: HumansAnimalsCells
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Social housing conditions and oxytocin and vasopressin receptors contribute to ethanol conditioned social preference in female mice. Physiol Behav. 2015 Nov 01; 151:469-77.
Wood RI, Knoll AT, Levitt P. PMID: 26282397.
View in: PubMed Mentions: Fields: Translation: Animals
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Kappa opioid receptor signaling in the basolateral amygdala regulates conditioned fear and anxiety in rats. Biol Psychiatry. 2011 Sep 01; 70(5):425-33.
Knoll AT, Muschamp JW, Sillivan SE, Ferguson D, Dietz DM, Meloni EG, Carroll FI, Nestler EJ, Konradi C, Carlezon WA. PMID: 21531393.
View in: PubMed Mentions: 57 Fields: Translation: AnimalsCells
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| Year | Publications |
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| 2011 | 1 | | 2015 | 1 | | 2016 | 1 | | 2017 | 1 | | 2019 | 1 |
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