 Allison Knoll
|
| Title(s) | Assistant Professor of Research Pediatrics |
|---|
| School | Keck School of Medicine of USC |
|---|
| Phone | +1 323 442 2776 |
|---|
| vCard | Download vCard |
|---|
|
|
 Biography | Harvard University, Cambridge, MA | PhD | 05/2010 | Neurobiology |
Overview My research focuses on understanding the genetic and environmental basis of individual differences in typical social behavior and in risk for neurodevelopmental disorders (NDDs). We model genetic diversity using large families of recombinant inbred mouse strains in which genetic variation is extensive, fixed, and well-characterized. Current studies focus on 1) identifying genes that underlie strain differences in sociability and cognition using quantitative trait locus mapping and advanced gene validation strategies, 2) examining the interaction between genetic background and common genetic risk variants for autism spectrum disorder (ASD) to identify the biological mechanisms underlying disorder risk/resilience, and 3) identifying the role of strain genetics in moderating risk/resilience to adverse outcomes associated with early-life stress. The goal of these studies is to understand the biology of heritable variation in sociability and cognition and to advance precision medicine approaches for the treatment of NDDs and early-adversity.
Bibliographic
-
Van Segbroeck M, Knoll AT, Levitt P, Narayanan S. MUPET-Mouse Ultrasonic Profile ExTraction: A Signal Processing Tool for Rapid and Unsupervised Analysis of Ultrasonic Vocalizations. Neuron. 2017 May 03; 94(3):465-485.e5. PMID: 28472651.
-
Knoll AT, Halladay LR, Holmes AJ, Levitt P. Quantitative Trait Loci and a Novel Genetic Candidate for Fear Learning. J Neurosci. 2016 06 08; 36(23):6258-68. PMID: 27277803; PMCID: PMC4899527 [Available on 12/08/16].
-
Wood RI, Knoll AT, Levitt P. Social housing conditions and oxytocin and vasopressin receptors contribute to ethanol conditioned social preference in female mice. Physiol Behav. 2015 Nov 01; 151:469-77. PMID: 26282397; PMCID: PMC4587335 [Available on 11/01/16].
-
Knoll AT, Muschamp JW, Sillivan SE, Ferguson D, Dietz DM, Meloni EG, Carroll FI, Nestler EJ, Konradi C, Carlezon WA. Kappa opioid receptor signaling in the basolateral amygdala regulates conditioned fear and anxiety in rats. Biol Psychiatry. 2011 Sep 01; 70(5):425-33. PMID: 21531393; PMCID: PMC3150294.
|
Concepts Derived automatically from this person's publications. _
Co-Authors People in Profiles who have published with this person. _
Similar People People who share similar concepts with this person. _
|