Alex K. Wong, MD

Title(s)Associate Professor Of Clinical Surgery
Address1510 San Pablo St.
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 7920
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    Collapse Biography 
    Collapse Education and Training
    Harvard Medical School, Boston, MAM.D.06/2002Medicine
    Cornell University, Ithaca, NYB.A.06/1997Biological Sciences
    Collapse Awards and Honors
    Harvard Medical School1999  - 2000Howard Hughes Medical Institute Fellowship
    USC2010  - 2012Robert E. and May R. Wright Foundation Award
    USC2010  - 2016Pasadena Magazine Top Doctor
    USC2013  - 2016SuperDoctors Rising Star
    USC2013  - 2016SC-CTSI KL2 Mentored Research Award

    Collapse Overview 
    Collapse Overview
    Dr. Alex K. Wong is an Associate Professor of Surgery in the Division of Plastic and Reconstructive Surgery. He is the Director of our Microvascular Surgery Fellowship Program, Director of Basic, Translation, and Clinical Research, and Director for Medical Student Education.

    Dr. Wong performs aesthetic surgery of the face, breast, and body. He has a special interest in breast augmentation with implants and autologous fat grafting. His reconstructive practice is focused on microsurgical free tissue transfer for the management of complex wounds, post-oncologic reconstruction, abdominal wall reconstruction, and lymphedema surgery. Dr. Wong has attending staff appointments at Keck University Hospital of USC, LAC+USC Medical Center, Huntington Memorial Hospital, and Garfield Medical Center.

    Some of Dr. Wong's many qualifications include: Member of the Society of University Surgeons, American Society of Plastic Surgeons, American Society for Reconstructive Microsurgery, World Society for Reconstructive Microsurgery, and Plastic Surgery Research Council. He is a Diplomat of the American Board of Plastic Surgery and Fellow of the American College of Surgeons. Dr. Wong has been named one of Pasadena Magazine's Top Doctors for every year since 2010, and is on the list of SuperDoctors/Los Angeles Magazine.

    As a member of the full time Keck School of Medicine USC faculty, Dr. Wong teaches and mentors the next generation of doctors and plastic surgeons. He serves as the Director of Plastic Surgery Visiting Clerkship at the Keck School of Medicine.

    In addition to his clinical practice, Dr. Wong directs a research laboratory with focus areas in lymphedema, adult-derived stem cells and novel biologics for wound healing, molecular pathogenesis of silicone breast implant capsular contracture, and microvascular flap physiology. Dr. Wong has received multiple grants and awards from organizations such as the National Institutes of Health, Howard Hughes Medical Institute, Plastic Surgery Educational Foundation, American Society for Maxillofacial Surgery, Wright Foundation, Whittier Foundation, American Cancer Society, and Southern California-Clinical Translational Science Institute (SC-CTSI). His work has been published in a variety of high impact peer reviewed journals.

    Prior to joining the faculty at USC, Dr. Wong completed his Fellowship training at the NYU Institute of Reconstructive Plastic Surgery and completed his formal Plastic Surgery residency at the University of Pittsburgh. Dr. Wong received his medical degree from Harvard Medical School and the Harvard-MIT Division of Health Sciences and Technology and is an honors graduate of the College of Arts and Sciences of Cornell University.

    Collapse Research 
    Collapse Research Activities and Funding
    Mitigation of lymphatic injury by retinoic acid therapy in a large animal model
    NIH R03HL154300Aug 1, 2020 - Jun 30, 2022
    Role: Principal Investigator
    Investigation of 9-cis Retinoic Acid as a Novel Treatment for Post-Surgical Lymphedema
    NIH K08HL132110Feb 1, 2017 - Jan 31, 2021
    Role: Principal Investigator

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    Collapse In The News
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    Collapse Required Scholarly Project Mentor

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. From Bench to Bedside: The Role of a Multidisciplinary Approach to Treating Patients with Lymphedema. Lymphat Res Biol. 2021 Feb 05. Lentz R, Shin C, Bloom Z, Yamada K, Hong YK, Wong AK, Patel K. PMID: 33544026.
      View in: PubMed   Mentions:    Fields:    
    2. Risk Factors for Wound Complications After Soft Tissue Sarcoma Resection. Ann Plast Surg. 2020 Nov 20. PMID: 33234885.
      View in: PubMed   Mentions:    Fields:    
    3. Role of stem cell therapies in treating chronic wounds: A systematic review. World J Stem Cells. 2020 Jul 26; 12(7):659-675. Raghuram AC, Yu RP, Lo AY, Sung CJ, Bircan M, Thompson HJ, Wong AK. PMID: 32843920.
      View in: PubMed   Mentions:
    4. Patient Characteristics Associated with Free Nipple Graft Reduction Mammoplasty. Cureus. 2020 Jul 08; 12(7):e9063. PMID: 32782881.
      View in: PubMed   Mentions:
    5. Supercharged Free Transverse Rectus Abdominis Myocutaneous Flap: An Autologous Reconstructive Option for the Thin Breast Reconstruction Patient. Cureus. 2020 Jun 22; 12(6):e8776. PMID: 32742826.
      View in: PubMed   Mentions:
    6. The Lymphatic Cell Environment Promotes Kaposi Sarcoma Development by Prox1-Enhanced Productive Lytic Replication of Kaposi Sarcoma Herpes Virus. Cancer Res. 2020 08 01; 80(15):3130-3144. Choi D, Park E, Kim KE, Jung E, Seong YJ, Zhao L, Madhavan S, Daghlian G, Lee HH, Daghlian PT, Daghlian S, Bui K, Koh CJ, Wong AK, Cho IT, Hong YK. PMID: 32518204.
      View in: PubMed   Mentions: 1     Fields:    
    7. Analysis of Trends in the Selection and Production of U.S. Academic Plastic Surgery Faculty. Plast Reconstr Surg Glob Open. 2020 Jan; 8(1):e2607. Daneshgaran G, Cooper MN, Ni P, Zhou S, Weichman KE, Wong AK. PMID: 32095411.
      View in: PubMed   Mentions:
    8. Ischemia and reperfusion injury in superficial inferior epigastric artery-based vascularized lymph node flaps. PLoS One. 2020; 15(1):e0227599. Perrault DP, Lee GK, Bouz A, Sung C, Yu R, Pourmoussa AJ, Park SY, Kim GH, Jiao W, Patel KM, Hong YK, Wong AK. PMID: 31923917.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    9. A Pre-clinical Animal Model of Secondary Head and Neck Lymphedema. Sci Rep. 2019 12 04; 9(1):18264. Daneshgaran G, Lo AY, Paik CB, Cooper MN, Sung C, Jiao W, Park SY, Ni P, Yu RP, Vorobyova I, Jashashvili T, Hong YK, Kim GH, Conti PS, Chai Y, Wong AK. PMID: 31797883.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    10. Analysis of the Microsurgery Match from 2014 to 2018 Reveals Increased Competition for Microsurgery Fellowship Positions. J Reconstr Microsurg. 2019 Nov; 35(9):662-668. Cooper MN, Daneshgaran G, Yu R, Chang J, Vartanian E, Shamsunder M, Mehrara BJ, Matros EM, Wong AK. PMID: 31302902.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Prevention of postsurgical lymphedema via immediate delivery of sustained-release 9-cis retinoic acid to the lymphedenectomy site. J Surg Oncol. 2020 Jan; 121(1):100-108. Daneshgaran G, Paik CB, Cooper MN, Sung C, Lo A, Jiao W, Park SY, Kim GH, Hong YK, Wong AK. PMID: 31240729.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    12. Mesenchymal Stromal Cells Isolated from Irradiated Human Skin Have Diminished Capacity for Proliferation, Differentiation, Colony Formation, and Paracrine Stimulation. Stem Cells Transl Med. 2019 09; 8(9):925-934. Johnson MB, Niknam-Bienia S, Soundararajan V, Pang B, Jung E, Gardner DJ, Xu X, Park SY, Wang C, Chen X, Baker RY, Chen M, Hong YK, Li W, Wong AK. PMID: 31020798.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    13. Piezo1 incorporates mechanical force signals into the genetic program that governs lymphatic valve development and maintenance. JCI Insight. 2019 03 07; 4(5). Choi D, Park E, Jung E, Cha B, Lee S, Yu J, Kim PM, Lee S, Hong YJ, Koh CJ, Cho CW, Wu Y, Li Jeon N, Wong AK, Shin L, Kumar SR, Bermejo-Moreno I, Srinivasan RS, Cho IT, Hong YK. PMID: 30676326.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    14. Complex Reconstruction of the Knee with a Free Vertical Rectus Abdominis Flap after Periprosthetic Soft Tissue Necrosis. Cureus. 2019 Jan 28; 11(1):e3969. Perrault D, Manrique OJ, Lee G, Carre AL, Oakes DA, Wong AK. PMID: 30956921.
      View in: PubMed   Mentions:
    15. Small Peptide Modulation of Fibroblast Growth Factor Receptor 3-Dependent Postnatal Lymphangiogenesis. Lymphat Res Biol. 2019 Feb; 17(1):19-29. Perrault DP, Lee GK, Park SY, Lee S, Choi D, Jung E, Seong YJ, Park EK, Sung C, Yu R, Bouz A, Pourmoussa A, Kim SJ, Hong YK, Wong AK. PMID: 30648916.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    16. Trochanteric pressure ulcers: preoperative management and reconstructive considerations. Ann Transl Med. 2019 Jan; 7(1):22. Daneshgaran G, Cooper MN, Park J, Pimentel CG, Wong AK. PMID: 30788369.
      View in: PubMed   Mentions:
    17. Risk Factors Associated with Reconstructive Complications Following Sacrectomy. Plast Reconstr Surg Glob Open. 2018 Nov; 6(11):e2002. Vartanian ED, Lynn JV, Perrault DP, Wolfswinkel EM, Kaiser AM, Patel KM, Carey JN, Hsieh PC, Wong AK. PMID: 30881800.
      View in: PubMed   Mentions:
    18. Human Acellular Dermis as Spacer for Small-Joint Arthroplasty: Analysis of Revascularization in a Rabbit Trapeziectomy Model. Plast Reconstr Surg. 2018 09; 142(3):679-686. Banks K, Squitieri L, Bramos A, Johnson MB, Gardner DJ, Pourmoussa AJ, Jung E, Lee GK, Perrault DP, Fedenko A, Kim GH, Han B, Hong YK, Kulber DA, Wong AK. PMID: 29878993.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    19. Local Administration of Interleukin-1 Receptor Antagonist Improves Diabetic Wound Healing. Ann Plast Surg. 2018 05; 80(5S Suppl 5):S317-S321. PMID: 29553981.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    20. Porcine Mesothelium-Wrapped Diced Cartilage Grafts for Nasal Reconstruction. Tissue Eng Part A. 2018 04; 24(7-8):672-681. Bramos A, Perrault DP, Fedenko AN, Kim GH, Bougioukli S, Lieberman JR, Calvert JW, Wong AK. PMID: 28922982.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    21. Updates on the Management of Non-Melanoma Skin Cancer (NMSC). Healthcare (Basel). 2017 Nov 01; 5(4). Fahradyan A, Howell AC, Wolfswinkel EM, Tsuha M, Sheth P, Wong AK. PMID: 29104226.
      View in: PubMed   Mentions:
    22. Development and Characterization of A Novel Prox1-EGFP Lymphatic and Schlemm's Canal Reporter Rat. Sci Rep. 2017 07 17; 7(1):5577. PMID: 28717161.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    23. Topical Fibronectin Improves Wound Healing of Irradiated Skin. Sci Rep. 2017 06 20; 7(1):3876. Johnson MB, Pang B, Gardner DJ, Niknam-Benia S, Soundarajan V, Bramos A, Perrault DP, Banks K, Lee GK, Baker RY, Kim GH, Lee S, Chai Y, Chen M, Li W, Kwong L, Hong YK, Wong AK. PMID: 28634413.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsPHPublic Health
    24. Radiomics-based Prognosis Analysis for Non-Small Cell Lung Cancer. Sci Rep. 2017 04 18; 7:46349. PMID: 28418006.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    25. Laminar flow downregulates Notch activity to promote lymphatic sprouting. J Clin Invest. 2017 Apr 03; 127(4):1225-1240. PMID: 28263185.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    26. ORAI1 Activates Proliferation of Lymphatic Endothelial Cells in Response to Laminar Flow Through Krüppel-Like Factors 2 and 4. Circ Res. 2017 Apr 28; 120(9):1426-1439. PMID: 28167653.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    27. Spinning Out of Control: A 19-Year-Old Female with Spinning-Related Exertional Thigh Compartment Syndrome. Cureus. 2016 Dec 24; 8(12):e939. PMID: 28123920.
      View in: PubMed   Mentions:
    28. An update and review of cell-based wound dressings and their integration into clinical practice. Ann Transl Med. 2016 Dec; 4(23):457. PMID: 28090513.
      View in: PubMed   Mentions:
    29. Integra-based Reconstruction of Large Scalp Wounds: A Case Report and Systematic Review of the Literature. Plast Reconstr Surg Glob Open. 2016 Oct; 4(10):e1074. PMID: 27826471.
      View in: PubMed   Mentions:
    30. Prevention of Postsurgical Lymphedema by 9-cis Retinoic Acid. Ann Surg. 2016 08; 264(2):353-61. PMID: 26655920.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    31. Efficient Assessment of Developmental, Surgical and Pathological Lymphangiogenesis Using a Lymphatic Reporter Mouse and Its Embryonic Stem Cells. PLoS One. 2016; 11(6):e0157126. PMID: 27280889.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    32. Identification of the critical therapeutic entity in secreted Hsp90a that promotes wound healing in newly re-standardized healthy and diabetic pig models. PLoS One. 2014; 9(12):e113956. PMID: 25464502.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    33. Determination of a perfusion threshold in experimental perforator flap surgery using indocyanine green angiography. Ann Plast Surg. 2014 Nov; 73(5):602-6. PMID: 24625512.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    34. Update and Review on the Surgical Management of Primary Cutaneous Melanoma. Healthcare (Basel). 2014 Jun 10; 2(2):234-49. PMID: 27429273.
      View in: PubMed   Mentions:
    35. Assessment of three-dimensional high-definition visualization technology to perform microvascular anastomosis. J Plast Reconstr Aesthet Surg. 2014 Jul; 67(7):967-72. PMID: 24838275.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    36. Abstract 31: DNA methylation analysis of radiated skin reveals chonic inflammation with a predominance of polymorphonuclear granulocytes. Plast Reconstr Surg. 2014 Mar; 133(3 Suppl):42. PMID: 25942142.
      View in: PubMed   Mentions:    Fields:    
    37. Analysis of risk factors associated with microvascular free flap failure using a multi-institutional database. Microsurgery. 2015 Jan; 35(1):6-12. PMID: 24431159.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    38. Metastasis of hepatocellular and renal cell carcinoma to the hand. Plast Reconstr Surg Glob Open. 2013 Dec; 1(9):e83. PMID: 25289277.
      View in: PubMed   Mentions:
    39. Simulation of plastic surgery and microvascular procedures using perfused fresh human cadavers. J Plast Reconstr Aesthet Surg. 2014 Feb; 67(2):e42-8. PMID: 24094541.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    40. Novel biomarkers of arterial and venous ischemia in microvascular flaps. PLoS One. 2013; 8(8):e71628. PMID: 23977093.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    41. Incidence of surgical-site infection is not affected by method of immediate breast reconstruction. Plast Reconstr Surg. 2013 Jul; 132(1):20e-29e. PMID: 23806951.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    42. Risk factors associated with venous thromboembolism in 49,028 mastectomy patients. Breast. 2013 Aug; 22(4):444-8. PMID: 23692931.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    43. The variation in the absence of the palmaris longus in a multiethnic population of the United States: an epidemiological study. Plast Surg Int. 2012; 2012:282959. PMID: 23213502.
      View in: PubMed   Mentions:
    44. Identifying risk factors for surgical site infections in mastectomy patients using the National Surgical Quality Improvement Program database. Am J Surg. 2013 Feb; 205(2):194-9. PMID: 22944390.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    45. Effect of immediate reconstruction on postmastectomy surgical site infection. Ann Surg. 2012 Aug; 256(2):326-33. PMID: 22791106.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    46. Breast implants and minimally invasive cardiac surgery: a case series. Ann Plast Surg. 2012 Jul; 69(1):10-3. Baker RY, Nguyen TJ, Hernandez AM, Wong AK, Baker CJ, Starnes VA. PMID: 21659843.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    47. A systematic review and meta-analysis of complications associated with acellular dermal matrix-assisted breast reconstruction. Ann Plast Surg. 2012 Apr; 68(4):346-56. PMID: 22421476.
      View in: PubMed   Mentions: 66     Fields:    Translation:Humans
    48. 9-cis retinoic acid promotes lymphangiogenesis and enhances lymphatic vessel regeneration: therapeutic implications of 9-cis retinoic acid for secondary lymphedema. Circulation. 2012 Feb 21; 125(7):872-82. PMID: 22275501.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    49. Use of human acellular dermal matrix in implant- based breast reconstruction: evaluating the evidence. J Plast Reconstr Aesthet Surg. 2011 Dec; 64(12):1553-61. JoAnna Nguyen T, Carey JN, Wong AK. PMID: 21388901.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    50. Radioprotection of osteoblasts by a fractionated dose regimen and amifostine. Plast Reconstr Surg. 2009 Feb; 123(2 Suppl):104S-113S. Wong AK, Mei L, Soares MA, Schönmeyr BH, Mehrara BJ. PMID: 19182669.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    51. Ionizing radiation of mesenchymal stem cells results in diminution of the precursor pool and limits potential for multilineage differentiation. Plast Reconstr Surg. 2008 Jul; 122(1):64-76. Schönmeyr BH, Wong AK, Soares M, Fernandez J, Clavin N, Mehrara BJ. PMID: 18594388.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    52. Hyperbaric oxygen inhibits growth but not differentiation of normal and irradiated osteoblasts. J Craniofac Surg. 2008 May; 19(3):757-65. Wong AK, Schönmeyr BH, Soares MA, Li S, Mehrara BJ. PMID: 18520395.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    53. Histologic analysis of angiogenesis and lymphangiogenesis in acellular human dermis. Plast Reconstr Surg. 2008 Apr; 121(4):1144-1152. Wong AK, Schonmeyer BH, Singh P, Carlson DL, Li S, Mehrara BJ. PMID: 18349631.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    54. Treatment of hydroxyapatite scaffolds with fibronectin and fetal calf serum increases osteoblast adhesion and proliferation in vitro. Plast Reconstr Surg. 2008 Mar; 121(3):751-762. Schönmeyr BH, Wong AK, Li S, Gewalli F, Cordiero PG, Mehrara BJ. PMID: 18317125.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    55. Soft-tissue coverage of the hand following sarcoma resection. Plast Reconstr Surg. 2008 Feb; 121(2):534-543. Talbot SG, Mehrara BJ, Disa JJ, Wong AK, Pusic A, Cordeiro PG, Athanasian EA. PMID: 18300973.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    56. The effect of hyperbaric oxygen treatment on squamous cell cancer growth and tumor hypoxia. Ann Plast Surg. 2008 Jan; 60(1):81-8. Schönmeyr BH, Wong AK, Reid VJ, Gewalli F, Mehrara BJ. PMID: 18281803.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    57. Excessive tumor-elaborated VEGF and its neutralization define a lethal paraneoplastic syndrome. Proc Natl Acad Sci U S A. 2001 Jun 19; 98(13):7481-6. Wong AK, Alfert M, Castrillon DH, Shen Q, Holash J, Yancopoulos GD, Chin L. PMID: 11404464.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    58. An inducible melanoma model implicates a role for RAS in tumor maintenance and angiogenesis. Cancer Metastasis Rev. 2000; 19(1-2):121-9. Wong AK, Chin L. PMID: 11191050.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
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