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    Akil Merchant, MD

    TitleAssistant Professor of Medicine
    SchoolKeck School of Medicine of USC
    DepartmentMedicine
    Address1450 Biggy St.
    Health Sciences Campus
    Los Angeles California 90033
    Phone+1 323 442 7796
    vCardDownload vCard

      Collapse Overview 
      Collapse Overview
      Dr. Merchant is Assistant Professor of Medicine at the USC Keck School of Medicine and practices at USC Norris Comprehensive Cancer Center. He attended medical school and residency at Baylor College of Medicine in Houston and then trained in Medical Oncology at Johns Hopkins University in Baltimore, where he joined the faculty as a junior investigator. Dr. Merchant was recruited to USC Norris Cancer Center in 2012, where his laboratory focuses on overcoming the resistance of leukemia stem cells to chemotherapy. He is the winner of numerous awards including the American Society of hematology Scholar Award, the American Society of Clinical Oncology Young Investigator Award, and the American Association for Cancer Research Fellowship. His research is currently funded by the NIH and the Whittier foundation.


      Collapse Biography 
      Collapse Awards and Honors
      Baylor College of Medicine 2002Caroline Law Award in Rheumatology
      American Society of Hematology 2007Travel Award
      AACR2009Scholar-in-Training Award

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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Chaudhry P, Singh M, Triche TJ, Guzman M, Merchant A. GLI3 repressor determines Hedgehog pathway activation and is required for response to SMO antagonist glasdegib in AML. Blood. 2017 Jun 29; 129(26):3465-3475. PMID: 28487292.
        View in: PubMed
      2. Singh M, Chaudhry P, Merchant A. Primary cilia are present on human blood and bone marrow cells and mediate Hedgehog signaling. Exp Hematol. 2016 Dec; 44(12):1181-1187.e2. PMID: 27612547.
        View in: PubMed
      3. Lim Y, Gondek L, Li L, Wang Q, Ma H, Ma H, Chang E, Huso DL, Foerster S, Marchionni L, McGovern K, Watkins DN, Peacock CD, Levis M, Smith BD, Merchant A, Small D, Matsui W. Integration of Hedgehog and mutant FLT3 signaling in myeloid leukemia. Sci Transl Med. 2015 Jun 10; 7(291):291ra96. PMID: 26062848; PMCID: PMC4644635.
      4. Agarwal JR, Wang Q, Tanno T, Rasheed Z, Merchant A, Ghosh N, Borrello I, Huff CA, Parhami F, Matsui W. Activation of liver X receptors inhibits hedgehog signaling, clonogenic growth, and self-renewal in multiple myeloma. Mol Cancer Ther. 2014 Jul; 13(7):1873-81. PMID: 24807964; PMCID: PMC4182725.
      5. Lim Y, Hedayati M, Merchant A, Zhang Y, Yu HH, Kastan MB, Matsui W, Deweese TL. Chloroquine improves survival and hematopoietic recovery after lethal low-dose-rate radiation. Int J Radiat Oncol Biol Phys. 2012 Nov 01; 84(3):800-6. PMID: 22445004; PMCID: PMC3388169.
      6. Merchant A, Roy CN. Not so benign haematology: anaemia of the elderly. Br J Haematol. 2012 Jan; 156(2):173-85. PMID: 22050828; PMCID: PMC3245355.
      7. Merchant A, Singh A, Matsui W, Biswal S. The redox-sensitive transcription factor Nrf2 regulates murine hematopoietic stem cell survival independently of ROS levels. Blood. 2011 Dec 15; 118(25):6572-9. PMID: 22039262; PMCID: PMC3242719.
      8. Lin TL, Wang QH, Brown P, Peacock C, Merchant A, Brennan S, Jones E, McGovern K, Watkins DN, Sakamoto KM, Matsui W. Self-renewal of acute lymphocytic leukemia cells is limited by the Hedgehog pathway inhibitors cyclopamine and IPI-926. PLoS One. 2010 Dec 28; 5(12):e15262. PMID: 21203400; PMCID: PMC3011010.
      9. Brennan SK, Meade B, Wang Q, Merchant A, Kowalski J, Matsui W. Mantle cell lymphoma activation enhances bortezomib sensitivity. Blood. 2010 Nov 18; 116(20):4185-91. PMID: 20570863; PMCID: PMC2993624.
      10. Merchant A, Matsui W. Targeting Hedgehog--a cancer stem cell pathway. Clin Cancer Res. 2010 Jun 15; 16(12):3130-40. PMID: 20530699; PMCID: PMC2888641.
      11. Merchant A, Joseph G, Wang Q, Brennan S, Matsui W. Gli1 regulates the proliferation and differentiation of HSCs and myeloid progenitors. Blood. 2010 Mar 25; 115(12):2391-6. PMID: 20107231; PMCID: PMC2845897.
      12. Merchant A, Matsui W. Smoothening the controversial role of hedgehog in hematopoiesis. Cell Stem Cell. 2009 Jun 05; 4(6):470-1. PMID: 19497273; PMCID: PMC4234099.
      13. Beauchamp E, Bulut G, Abaan O, Chen K, Merchant A, Matsui W, Endo Y, Rubin JS, Toretsky J, Uren A. GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein. J Biol Chem. 2009 Apr 03; 284(14):9074-82. PMID: 19189974; PMCID: PMC2666556.
      14. Chambers SM, Boles NC, Lin KY, Tierney MP, Bowman TV, Bradfute SB, Chen AJ, Merchant A, Sirin O, Weksberg DC, Merchant MG, Fisk CJ, Shaw CA, Goodell MA. Hematopoietic fingerprints: an expression database of stem cells and their progeny. Cell Stem Cell. 2007 Nov; 1(5):578-91. PMID: 18371395; PMCID: PMC2475548.
      15. Bowman TV, Merchant A, Goodell MA. Molecular profiling of hematopoietic stem cells. Methods Mol Med. 2007; 134:1-16. PMID: 17666739.
        View in: PubMed
      16. Ramos CA, Bowman TA, Boles NC, Merchant A, Zheng Y, Parra I, Fuqua SA, Shaw CA, Goodell MA. Evidence for diversity in transcriptional profiles of single hematopoietic stem cells. PLoS Genet. 2006 Sep 29; 2(9):e159. PMID: 17009876; PMCID: PMC1584276.
      17. Bowman TV, McCooey AJ, Merchant A, Ramos CA, Fonseca P, Poindexter A, Bradfute SB, Oliveira DM, Green R, Zheng Y, Jackson KA, Chambers SM, McKinney-Freeman SL, Norwood KG, Darlington G, Gunaratne PH, Steffen D, Goodell MA. Differential mRNA processing in hematopoietic stem cells. Stem Cells. 2006 Mar; 24(3):662-70. PMID: 16373690.
        View in: PubMed
      18. Venezia TA, Merchant A, Ramos CA, Whitehouse NL, Young AS, Shaw CA, Goodell MA. Molecular signatures of proliferation and quiescence in hematopoietic stem cells. PLoS Biol. 2004 Oct; 2(10):e301. PMID: 15459755; PMCID: PMC520599.
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