Akil Merchant, MD

TitleAssistant Professor of Medicine
InstitutionUniversity of Southern California
Address1450 Biggy St.
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 7796
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    Collapse Biography 
    Collapse Awards and Honors
    Baylor College of Medicine 2002Caroline Law Award in Rheumatology
    American Society of Hematology 2007Travel Award
    AACR2009Scholar-in-Training Award

    Collapse Overview 
    Collapse Overview
    Dr. Merchant is Assistant Professor of Medicine at the USC Keck School of Medicine and practices at USC Norris Comprehensive Cancer Center. He attended medical school and residency at Baylor College of Medicine in Houston and then trained in Medical Oncology at Johns Hopkins University in Baltimore, where he joined the faculty as a junior investigator. Dr. Merchant was recruited to USC Norris Cancer Center in 2012, where his laboratory focuses on overcoming the resistance of leukemia stem cells to chemotherapy. He is the winner of numerous awards including the American Society of hematology Scholar Award, the American Society of Clinical Oncology Young Investigator Award, and the American Association for Cancer Research Fellowship. His research is currently funded by the NIH and the Whittier foundation.

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Cortes JE, Smith BD, Wang ES, Merchant A, Oehler VG, Arellano M, DeAngelo DJ, Pollyea DA, Sekeres MA, Robak T, Ma WW, Zeremski M, Shaik MN, Laird AD, O'Connell A, Chan G, Schroeder MA. Glasdegib in combination with cytarabine and daunorubicin in patients with AML or high-risk MDS: Phase 2 study results. Am J Hematol. 2018 Aug 03. PMID: 30074259.
      View in: PubMed
    2. Igwe IJ, Yang D, Merchant A, Merin N, Yaghmour G, Kelly K, Ramsingh G. The presence of Philadelphia chromosome does not confer poor prognosis in adult pre-B acute lymphoblastic leukaemia in the tyrosine kinase inhibitor era - a surveillance, epidemiology, and end results database analysis. Br J Haematol. 2017 11; 179(4):618-626. PMID: 29047122.
      View in: PubMed
    3. Merchant AA, Jorapur A, McManus A, Liu R, Krasnoperov V, Chaudhry P, Singh M, Harton L, Agajanian M, Kim M, Triche TJ, Druker BJ, Tyner JW, Gill PS. EPHB4 is a therapeutic target in AML and promotes leukemia cell survival via AKT. Blood Adv. 2017 Sep 12; 1(20):1635-1644. PMID: 29296810.
      View in: PubMed
    4. Kantarjian HM, DeAngelo DJ, Advani AS, Stelljes M, Kebriaei P, Cassaday RD, Merchant AA, Fujishima N, Uchida T, Calbacho M, Ejduk AA, O'Brien SM, Jabbour EJ, Zhang H, Sleight BJ, Vandendries ER, Marks DI. Hepatic adverse event profile of inotuzumab ozogamicin in adult patients with relapsed or refractory acute lymphoblastic leukaemia: results from the open-label, randomised, phase 3 INO-VATE study. Lancet Haematol. 2017 Aug; 4(8):e387-e398. PMID: 28687420.
      View in: PubMed
    5. Chaudhry P, Singh M, Triche TJ, Guzman M, Merchant AA. GLI3 repressor determines Hedgehog pathway activation and is required for response to SMO antagonist glasdegib in AML. Blood. 2017 06 29; 129(26):3465-3475. PMID: 28487292.
      View in: PubMed
    6. Singh M, Chaudhry P, Merchant AA. Primary cilia are present on human blood and bone marrow cells and mediate Hedgehog signaling. Exp Hematol. 2016 Dec; 44(12):1181-1187.e2. PMID: 27612547.
      View in: PubMed
    7. Lim Y, Gondek L, Li L, Wang Q, Ma H, Ma H, Chang E, Huso DL, Foerster S, Marchionni L, McGovern K, Watkins DN, Peacock CD, Levis M, Smith BD, Merchant AA, Small D, Matsui W. Integration of Hedgehog and mutant FLT3 signaling in myeloid leukemia. Sci Transl Med. 2015 Jun 10; 7(291):291ra96. PMID: 26062848; PMCID: PMC4644635.
    8. Agarwal JR, Wang Q, Tanno T, Rasheed Z, Merchant A, Ghosh N, Borrello I, Huff CA, Parhami F, Matsui W. Activation of liver X receptors inhibits hedgehog signaling, clonogenic growth, and self-renewal in multiple myeloma. Mol Cancer Ther. 2014 Jul; 13(7):1873-81. PMID: 24807964; PMCID: PMC4182725.
    9. Lim Y, Hedayati M, Merchant AA, Zhang Y, Yu HH, Kastan MB, Matsui W, Deweese TL. Chloroquine improves survival and hematopoietic recovery after lethal low-dose-rate radiation. Int J Radiat Oncol Biol Phys. 2012 Nov 01; 84(3):800-6. PMID: 22445004; PMCID: PMC3388169.
    10. Merchant AA, Roy CN. Not so benign haematology: anaemia of the elderly. Br J Haematol. 2012 Jan; 156(2):173-85. PMID: 22050828; PMCID: PMC3245355.
    11. Merchant AA, Singh A, Matsui W, Biswal S. The redox-sensitive transcription factor Nrf2 regulates murine hematopoietic stem cell survival independently of ROS levels. Blood. 2011 Dec 15; 118(25):6572-9. PMID: 22039262; PMCID: PMC3242719.
    12. Lin TL, Wang QH, Brown P, Peacock C, Merchant AA, Brennan S, Jones E, McGovern K, Watkins DN, Sakamoto KM, Matsui W. Self-renewal of acute lymphocytic leukemia cells is limited by the Hedgehog pathway inhibitors cyclopamine and IPI-926. PLoS One. 2010 Dec 28; 5(12):e15262. PMID: 21203400; PMCID: PMC3011010.
    13. Brennan SK, Meade B, Wang Q, Merchant AA, Kowalski J, Matsui W. Mantle cell lymphoma activation enhances bortezomib sensitivity. Blood. 2010 Nov 18; 116(20):4185-91. PMID: 20570863; PMCID: PMC2993624.
    14. Merchant AA, Matsui W. Targeting Hedgehog--a cancer stem cell pathway. Clin Cancer Res. 2010 Jun 15; 16(12):3130-40. PMID: 20530699; PMCID: PMC2888641.
    15. Merchant A, Joseph G, Wang Q, Brennan S, Matsui W. Gli1 regulates the proliferation and differentiation of HSCs and myeloid progenitors. Blood. 2010 Mar 25; 115(12):2391-6. PMID: 20107231; PMCID: PMC2845897.
    16. Merchant AA, Matsui W. Smoothening the controversial role of hedgehog in hematopoiesis. Cell Stem Cell. 2009 Jun 05; 4(6):470-1. PMID: 19497273; PMCID: PMC4234099.
    17. Beauchamp E, Bulut G, Abaan O, Chen K, Merchant A, Matsui W, Endo Y, Rubin JS, Toretsky J, Uren A. GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein. J Biol Chem. 2009 Apr 03; 284(14):9074-82. PMID: 19189974; PMCID: PMC2666556.
    18. Chambers SM, Boles NC, Lin KY, Tierney MP, Bowman TV, Bradfute SB, Chen AJ, Merchant AA, Sirin O, Weksberg DC, Merchant MG, Fisk CJ, Shaw CA, Goodell MA. Hematopoietic fingerprints: an expression database of stem cells and their progeny. Cell Stem Cell. 2007 Nov; 1(5):578-91. PMID: 18371395; PMCID: PMC2475548.
    19. Bowman TV, Merchant AA, Goodell MA. Molecular profiling of hematopoietic stem cells. Methods Mol Med. 2007; 134:1-16. PMID: 17666739.
      View in: PubMed
    20. Ramos CA, Bowman TA, Boles NC, Merchant AA, Zheng Y, Parra I, Fuqua SA, Shaw CA, Goodell MA. Evidence for diversity in transcriptional profiles of single hematopoietic stem cells. PLoS Genet. 2006 Sep 29; 2(9):e159. PMID: 17009876; PMCID: PMC1584276.
    21. Bowman TV, McCooey AJ, Merchant AA, Ramos CA, Fonseca P, Poindexter A, Bradfute SB, Oliveira DM, Green R, Zheng Y, Jackson KA, Chambers SM, McKinney-Freeman SL, Norwood KG, Darlington G, Gunaratne PH, Steffen D, Goodell MA. Differential mRNA processing in hematopoietic stem cells. Stem Cells. 2006 Mar; 24(3):662-70. PMID: 16373690.
      View in: PubMed
    22. Venezia TA, Merchant AA, Ramos CA, Whitehouse NL, Young AS, Shaw CA, Goodell MA. Molecular signatures of proliferation and quiescence in hematopoietic stem cells. PLoS Biol. 2004 Oct; 2(10):e301. PMID: 15459755; PMCID: PMC520599.