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    Zhongwei Li, PhD

    TitleAssistant Professor of Medicine and Stem Cell Biology and Regenerative Medicine
    SchoolKeck School of Medicine of USC
    AddressMMR #618
    Off Campus
    Los Angeles California 90033
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      Collapse Overview 
      Collapse Overview
      Organ transplantation saves lives. However, the gap between organ supply and organ demand is ever increasing. Kidneys account for more than 80% of the donor organs needed by patients awaiting transplantation. Thus, it is an urgent task to find ways to build transplantable kidneys. My research aims to bridge basic studies of kidney organogenesis and translational applications of stem/progenitor cell-based kidney regeneration and disease modeling, with the long-term goal of rebuilding the kidney. State-of-the-art stem cell technologies and engineering methodologies are combined in my research to achieve these goals.

      Collapse Biography 
      Collapse Education and Training
      Salk Institute for Biological Studies, La Jolla, CaliforniaPostdoc08/2017Stem Cell and Regenerative Medicine
      Tsinghua University, Beijing, ChinaPhD07/2012Molecular Cell Biology
      Sichuan University, Chengdu, ChinaBS07/2007Biotechnology
      Collapse Awards and Honors
      Institute of Scientific and Technical Information of China (ISTIC)2013Top 100 Influential Research Articles in China (2012)
      Ray Wu Memorial Fund2012Ray Wu Prize
      Johnson & Johnson2012"Johnson & Johnson Asia Outstanding Thesis Award in Bio-tech", 1st Prize
      City of Beijing2012Outstanding Ph.D. Graduate Award
      Tsinghua University2012Outstanding Ph.D. Graduate Award
      Tsinghua University2012Outstanding Ph.D. Thesis Award
      Sichuan University2007Outstanding Undergraduate Award
      Sichuan University2007Outstanding Undergraduate Thesis Award

      Collapse ORNG Applications 
      Collapse Websites

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Yang Y, Liu B, Xu J, Wang J, Wu J, Shi C, Xu Y, Dong J, Wang C, Lai W, Zhu J, Xiong L, Zhu D, Li X, Yang W, Yamauchi T, Sugawara A, Li Z, Sun F, Li X, Li C, He A, Du Y, Wang T, Zhao C, Li H, Chi X, Zhang H, Liu Y, Li C, Duo S, Yin M, Shen H, Belmonte JC, Deng H. Derivation of Pluripotent Stem Cells with In Vivo Embryonic and Extraembryonic Potency. Cell. 2017 Apr 06; 169(2):243-257.e25. PMID: 28388409.
        View in: PubMed
      2. Wang L, Xu X, Cao Y, Li Z, Cheng H, Zhu G, Duan F, Na J, Han JJ, Chen YG. Activin/Smad2-induced Histone H3 Lys-27 Trimethylation (H3K27me3) Reduction Is Crucial to Initiate Mesendoderm Differentiation of Human Embryonic Stem Cells. J Biol Chem. 2017 Jan 27; 292(4):1339-1350. PMID: 27965357.
        View in: PubMed
      3. Li Z, Araoka T, Wu J, Liao HK, Li M, Lazo M, Zhou B, Sui Y, Wu MZ, Tamura I, Xia Y, Beyret E, Matsusaka T, Pastan I, Rodriguez Esteban C, Guillen I, Guillen P, Campistol JM, Izpisua Belmonte JC. 3D Culture Supports Long-Term Expansion of Mouse and Human Nephrogenic Progenitors. Cell Stem Cell. 2016 Oct 06; 19(4):516-529. PMID: 27570066.
        View in: PubMed
      4. Zhu G, Fei T, Li Z, Yan X, Chen YG. Activin Regulates Self-renewal and Differentiation of Trophoblast Stem Cells by Down-regulating the X Chromosome Gene Bcor. J Biol Chem. 2015 Sep 04; 290(36):22019-29. PMID: 26221038; PMCID: PMC4571955.
      5. Wu J, Okamura D, Li M, Suzuki K, Luo C, Ma L, He Y, Li Z, Benner C, Tamura I, Krause MN, Nery JR, Du T, Zhang Z, Hishida T, Takahashi Y, Aizawa E, Kim NY, Lajara J, Guillen P, Campistol JM, Esteban CR, Ross PJ, Saghatelian A, Ren B, Ecker JR, Izpisua Belmonte JC. An alternative pluripotent state confers interspecies chimaeric competency. Nature. 2015 May 21; 521(7552):316-21. PMID: 25945737.
        View in: PubMed
      6. Zhang J, Fei T, Li Z, Zhu G, Wang L, Chen YG. BMP induces cochlin expression to facilitate self-renewal and suppress neural differentiation of mouse embryonic stem cells. J Biol Chem. 2013 Mar 22; 288(12):8053-60. PMID: 23344953; PMCID: PMC3605624.
      7. Li Z, Huylebroeck D, Chen YG. TGF-ß in Human Disease (Chapter 2). 2013.
      8. Li Z, Chen YG. Functions of BMP signaling in embryonic stem cell fate determination. Exp Cell Res. 2013 Jan 15; 319(2):113-9. PMID: 23051821.
        View in: PubMed
      9. Li Z, Chen YG. Fine-tune of intrinsic ERK activity by extrinsic BMP signaling in mouse embryonic stem cells. Protein Cell. 2012 Jun; 3(6):401-4. PMID: 22528752; PMCID: PMC4875488.
      10. Chen YG, Li Z, Wang XF. Where PI3K/Akt meets Smads: the crosstalk determines human embryonic stem cell fate. Cell Stem Cell. 2012 Mar 02; 10(3):231-2. PMID: 22385648; PMCID: PMC3586792.
      11. Li Z, Fei T, Zhang J, Zhu G, Wang L, Lu D, Chi X, Teng Y, Hou N, Yang X, Zhang H, Han JD, Chen YG. BMP4 Signaling Acts via dual-specificity phosphatase 9 to control ERK activity in mouse embryonic stem cells. Cell Stem Cell. 2012 Feb 03; 10(2):171-82. PMID: 22305567.
        View in: PubMed
      12. Fei T, Zhu S, Xia K, Zhang J, Li Z, Han JD, Chen YG. Smad2 mediates Activin/Nodal signaling in mesendoderm differentiation of mouse embryonic stem cells. Cell Res. 2010 Dec; 20(12):1306-18. PMID: 21079647.
        View in: PubMed
      13. Fei T, Xia K, Li Z, Zhou B, Zhu S, Chen H, Zhang J, Chen Z, Xiao H, Han JD, Chen YG. Genome-wide mapping of SMAD target genes reveals the role of BMP signaling in embryonic stem cell fate determination. Genome Res. 2010 Jan; 20(1):36-44. PMID: 19926752; PMCID: PMC2798829.