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    Zhang-Xu Liu, MD, PhD

    TitleAssistant Professor of Research Medicine
    SchoolKeck School of Medicine of USC
    AddressHMR 803
    Health Sciences Campus
    Los Angeles California 90089-9091
    Phone+1 323 442 3233
    vCardDownload vCard

      Collapse Overview 
      Collapse Overview
      Dr. Liu's research interests include fucnation of liver NK and NKT cells, liver immunology and diseases, innate immunity in drug-induced hepatotoxicity, and immunity in alcoholic hepatitis. He is currently an Associate Editor of World Journal of Gastroenterology.

      Dr. Liu earned his medical degree from Chongqing Medical University. He then went on to complete his master's degree at Sichuan University West China Medical School, followed by a PhD from Tohoku University School of Medicine.

      Collapse Biography 
      Collapse Awards and Honors
      Japanese Government (Mobusho)1992  - 1997Fellowship
      Japanese Society of Gastroenterology1997Award
      American Digestive Health Foundation1999Travel Award

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Dara L, Liu Z, Kaplowitz N. Mechanisms of adaptation and progression in idiosyncratic drug induced liver injury, clinical implications. Liver Int. 2016 Feb; 36(2):158-65. PMID: 26484420; PMCID: PMC4718752 [Available on 02/01/17].
      2. Kaplowitz N, Win S, Than TA, Liu Z, Dara L. Targeting signal transduction pathways which regulate necrosis in acetaminophen hepatotoxicity. J Hepatol. 2015 Jul; 63(1):5-7. PMID: 25770661.
        View in: PubMed
      3. Wen SL, Gao JH, Yang WJ, Lu YY, Tong H, Huang ZY, Liu Z, Tang CW. Celecoxib attenuates hepatic cirrhosis through inhibition of epithelial-to-mesenchymal transition of hepatocytes. J Gastroenterol Hepatol. 2014 Nov; 29(11):1932-42. PMID: 24909904.
        View in: PubMed
      4. Gao JH, Wen SL, Yang WJ, Lu YY, Tong H, Huang ZY, Liu Z, Tang CW. Celecoxib ameliorates portal hypertension of the cirrhotic rats through the dual inhibitory effects on the intrahepatic fibrosis and angiogenesis. PLoS One. 2013; 8(7):e69309. PMID: 23922700; PMCID: PMC3724827.
      5. Han D, Dara L, Win S, Than TA, Yuan L, Abbasi SQ, Liu Z, Kaplowitz N. Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria. Trends Pharmacol Sci. 2013 Apr; 34(4):243-53. PMID: 23453390; PMCID: PMC3622802.
      6. Inokuchi S, Tsukamoto H, Park E, Liu Z, Brenner DA, Seki E. Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice. Alcohol Clin Exp Res. 2011 Aug; 35(8):1509-18. PMID: 21463341; PMCID: PMC3131439.
      7. Kaplowitz N, Shinohara M, Liu Z, Han D. How to protect against acetaminophen: don't ask for JUNK. Gastroenterology. 2008 Oct; 135(4):1047-51. PMID: 18782575.
        View in: PubMed
      8. Liu Z, Kaplowitz N. Role of innate immunity in acetaminophen-induced hepatotoxicity. Expert Opin Drug Metab Toxicol. 2006 Aug; 2(4):493-503. PMID: 16859400.
        View in: PubMed
      9. Gunawan BK, Liu Z, Han D, Hanawa N, Gaarde WA, Kaplowitz N. c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity. Gastroenterology. 2006 Jul; 131(1):165-78. PMID: 16831600.
        View in: PubMed
      10. Liu Z, Han D, Gunawan B, Kaplowitz N. Neutrophil depletion protects against murine acetaminophen hepatotoxicity. Hepatology. 2006 Jun; 43(6):1220-30. PMID: 16729305.
        View in: PubMed
      11. Liu Z, Govindarajan S, Kaplowitz N. Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity. Gastroenterology. 2004 Dec; 127(6):1760-74. PMID: 15578514.
        View in: PubMed
      12. Minagawa M, Deng Q, Liu Z, Tsukamoto H, Dennert G. Activated natural killer T cells induce liver injury by Fas and tumor necrosis factor-alpha during alcohol consumption. Gastroenterology. 2004 May; 126(5):1387-99. PMID: 15131799.
        View in: PubMed
      13. Arai K, Liu Z, Lane T, Dennert G. IP-10 and Mig facilitate accumulation of T cells in the virus-infected liver. Cell Immunol. 2002 Sep; 219(1):48-56. PMID: 12473267.
        View in: PubMed
      14. Liu Z, Kaplowitz N. Immune-mediated drug-induced liver disease. Clin Liver Dis. 2002 Aug; 6(3):755-74. PMID: 12362579.
        View in: PubMed
      15. Liu Z, Nishida H, He JW, Lai MM, Feng N, Dennert G. Hepatitis C virus genotype 1b core protein does not exert immunomodulatory effects on virus-induced cellular immunity. J Virol. 2002 Feb; 76(3):990-7. PMID: 11773374; PMCID: PMC135789.