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    Yang Chai, DMD, PhD, DDS

    TitleProfessor and Associate Dean, Research and Director, Center For Craniofacial Molecular Biology
    SchoolHerman Ostrow School of Dentistry of USC
    DepartmentBiomedical Engineering
    AddressCSA 148
    Health Sciences Campus
    Los Angeles California 90089-9062
    Phone+1 323 442 3480
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      Yang Chai, DMD, PhD, DDS is the chair of the National Institute of Dental and Craniofacial Research Board of Scientific Counselors.

      Professor Chai, who holds the George and Mary Lou Boone Chair in Craniofacial Biology and is the associate dean of research and director of the Center for Craniofacial Molecular Biology at the Ostrow School, has been a member of the board since 2008 and will serve a one-year term as chair. A total of nine board members, including the chair, are selected from among the most accomplished and celebrated experts in biomedical, dental and craniofacial science.

      Chai is internationally renowned for his research into the genetics, cellular signaling, and development of cranial and facial structures, including the causes of and potential preventive measures for facial deformities such as cleft palate. Among his many honors, he has received a National Institutes of Health MERIT Award, has been elected as an American Association for the Advancement of Sciences Fellow, has received an International Association for Dental Research Distinguished Scientist Award, and has served on the editorial boards of several scientific journals. He is also an alumnus of the Ostrow School of Dentistry and is an award-winning educator and a practicing dentist at the school.

      Collapse Biography 
      Collapse Awards and Honors
      NIDCR, NIH2013Chair of the Board of Scientific Counselors
      Craniofacial Biology Research Award2011IADR Distinguished Scientist Award
      Journal of Bone and Mineral Research2010  - 2014Editorial Board
      NIH2010 NIH MERIT Award
      2010American Association for the Advancement of Sciences (AAAS) Elected Fellow
      NIDCR, NIH2008  - 2012Member of the Board of Scientific Counselors
      JBMR2007  - 2014Editorial Board DEVELOPMENTAL BIOLOGY
      The Chinese Journal of Dental Research2006  - 2014Editorial Board
      2004  - 2008Regular member of SBDD study section CSR NIH
      2004Chair, Gordon Research Conference on Craniofacial Morphogenesis and Tissue Regeneration
      2006Chair, Gordon Research Conference on Craniofacial Morphogenesis and Tissue Regeneration
      2002  - 2014NIH Ad hoc grant reviewer (OBM-2, ODCS) and Reviewer for the Welcome Trust, UK
      University of Southern California2001  - 2003Award of Excellence in Teaching
      University of Southern California1997James H. Zumberge Faculty Research and Innovation Award
      University of Southern California2007James H. Zumberge Faculty Research and Innovation Award
      University of Southern California1997Annual Excellence in Teaching Award
      1996OKU Scholarship award for outstanding academic performance
      1996Special Recognition by the Dean for outstanding service and contribution to the University of Southe
      University of Southern California, School of Dentistry1995Annual Teaching Award
      University of Southern California, (GPA 4.0)1991PHI KAPPA PHI, All-University Honor Society
      University of Southern California1990Certificate for Outstanding Academic Achievement

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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. He D, Qiao J, Zhang L, Wang J, Lan T, Qian J, Li Y, Shi Y, Chai Y, Lan W, Ono LK, Qi Y, Xu JB, Ji W, Wang X. Ultrahigh mobility and efficient charge injection in monolayer organic thin-film transistors on boron nitride. Sci Adv. 2017 Sep; 3(9):e1701186. PMID: 28913429.
        View in: PubMed
      2. Zhao J, Liang WB, Lei YM, Ou YX, Chai Y, Yuan R, Zhuo Y. An efficient electrochemiluminescence amplification strategy via bis-co-reaction accelerator for sensitive detection of laminin to monitor overnutrition associated liver damage. Biosens Bioelectron. 2017 Dec 15; 98:317-324. PMID: 28697444.
        View in: PubMed
      3. Johnson MB, Pang B, Gardner DJ, Niknam-Benia S, Soundarajan V, Bramos A, Perrault DP, Banks K, Lee GK, Baker RY, Kim GH, Lee S, Chai Y, Chen M, Li W, Kwong L, Hong YK, Wong AK. Topical Fibronectin Improves Wound Healing of Irradiated Skin. Sci Rep. 2017 Jun 20; 7(1):3876. PMID: 28634413.
        View in: PubMed
      4. Ma S, Zeng L, Tao L, Tang CY, Yuan H, Long H, Cheng PK, Chai Y, Chen C, Fung KH, Zhang X, Lau SP, Tsang YH. Enhanced Photocatalytic Activity of WS2 Film by Laser Drilling to Produce Porous WS2/WO3 Heterostructure. Sci Rep. 2017 Jun 09; 7(1):3125. PMID: 28600560.
        View in: PubMed
      5. Feng J, Jing J, Li J, Zhao H, Punj V, Zhang T, Xu J, Chai Y. BMP signaling orchestrates a transcriptional network to control the fate of mesenchymal stem cells in mice. Development. 2017 Jul 15; 144(14):2560-2569. PMID: 28576771.
        View in: PubMed
      6. Tian H, Feng J, Li J, Ho TV, Yuan Y, Liu Y, Brindopke F, Figueiredo JC, Magee W, Sanchez-Lara PA, Chai Y. Intraflagellar transport 88 (IFT88) is crucial for craniofacial development in mice and is a candidate gene for human cleft lip and palate. Hum Mol Genet. 2017 Mar 01; 26(5):860-872. PMID: 28069795.
        View in: PubMed
      7. Li J, Parada C, Chai Y. Cellular and molecular mechanisms of tooth root development. Development. 2017 Feb 01; 144(3):374-384. PMID: 28143844.
        View in: PubMed
      8. Gao YL, Lu B, Zhai JH, Liu YC, Qi HX, Yao Y, Chai Y, Shou ST. The Parenteral Vitamin C Improves Sepsis and Sepsis-Induced Multiple Organ Dysfunction Syndrome via Preventing Cellular Immunosuppression. Mediators Inflamm. 2017; 2017:4024672. PMID: 28210072.
        View in: PubMed
      9. Long M, Zhang T, Chai Y, Ng CF, Mak TC, Xu J, Yan K. Nonstoichiometric acid-base reaction as reliable synthetic route to highly stable CH3NH3PbI3 perovskite film. Nat Commun. 2016 Nov 15; 7:13503. PMID: 27843140.
        View in: PubMed
      10. Park S, Zhao H, Urata M, Chai Y. Sutures Possess Strong Regenerative Capacity for Calvarial Bone Injury. Stem Cells Dev. 2016 Dec 01; 25(23):1801-1807. PMID: 27762665.
        View in: PubMed
      11. Sun Z, Yu W, Sanz Navarro M, Sweat M, Eliason S, Sharp T, Liu H, Seidel K, Zhang L, Moreno M, Lynch T, Holton NE, Rogers L, Neff T, Goodheart MJ, Michon F, Klein OD, Chai Y, Dupuy A, Engelhardt JF, Chen Z, Amendt BA. Sox2 and Lef-1 interact with Pitx2 to regulate incisor development and stem cell renewal. Development. 2016 Nov 15; 143(22):4115-4126. PMID: 27660324.
        View in: PubMed
      12. Feng J, Jing J, Sanchez-Lara PA, Bootwalla MS, Buckley J, Wu N, Yan Y, Chai Y. Generation and characterization of tamoxifen-inducible Pax9-CreER knock-in mice using CrispR/Cas9. Genesis. 2016 Sep; 54(9):490-6. PMID: 27381449; PMCID: PMC5021577 [Available on 09/01/17].
      13. Zhao J, Lei YM, Chai Y, Yuan R, Zhuo Y. Novel electrochemiluminescence of perylene derivative and its application to mercury ion detection based on a dual amplification strategy. Biosens Bioelectron. 2016 Dec 15; 86:720-7. PMID: 27474970.
        View in: PubMed
      14. Brinkley JF, Fisher S, Harris MP, Holmes G, Hooper JE, Jabs EW, Jones KL, Kesselman C, Klein OD, Maas RL, Marazita ML, Selleri L, Spritz RA, van Bakel H, Visel A, Williams TJ, Wysocka J, Chai Y. The FaceBase Consortium: a comprehensive resource for craniofacial researchers. Development. 2016 Jul 15; 143(14):2677-88. PMID: 27287806; PMCID: PMC4958338.
      15. Gao YL, Chai Y, Qi AL, Yao Y, Liu YC, Dong N, Wang LJ, Yao YM. Neuropilin-1highCD4?CD25? Regulatory T Cells Exhibit Primary Negative Immunoregulation in Sepsis. Mediators Inflamm. 2016; 2016:7132158. PMID: 27239104; PMCID: PMC4863118.
      16. Burg ML, Chai Y, Yao CA, Magee W, Figueiredo JC. Epidemiology, Etiology, and Treatment of Isolated Cleft Palate. Front Physiol. 2016; 7:67. PMID: 26973535; PMCID: PMC4771933.
      17. Grimaldi A, Parada C, Chai Y. A Comprehensive Study of Soft Palate Development in Mice. PLoS One. 2015; 10(12):e0145018. PMID: 26671681; PMCID: PMC4687642.
      18. Gao YL, Chai Y, Dong N, Han S, Zhu XM, Zhang QH, Yao YM. Tuftsin-derived T-peptide prevents cellular immunosuppression and improves survival rate in septic mice. Sci Rep. 2015 Nov 18; 5:16725. PMID: 26577833; PMCID: PMC4649719.
      19. Parada C, Chai Y. Mandible and Tongue Development. Curr Top Dev Biol. 2015; 115:31-58. PMID: 26589920; PMCID: PMC4869709.
      20. Parada C, Han D, Grimaldi A, Sarrión P, Park SS, Pelikan R, Sanchez-Lara PA, Chai Y. Disruption of the ERK/MAPK pathway in neural crest cells as a potential cause of Pierre Robin sequence. Development. 2015 Nov 01; 142(21):3734-45. PMID: 26395480; PMCID: PMC4647211 [Available on 11/01/16].
      21. Zhao H, Chai Y. Stem Cells in Teeth and Craniofacial Bones. J Dent Res. 2015 Nov; 94(11):1495-501. PMID: 26350960; PMCID: PMC4622324 [Available on 11/01/16].
      22. Liu Y, Feng J, Li J, Zhao H, Ho TV, Chai Y. An Nfic-hedgehog signaling cascade regulates tooth root development. Development. 2015 Oct 01; 142(19):3374-82. PMID: 26293299; PMCID: PMC4631759 [Available on 10/01/16].
      23. Li J, Feng J, Liu Y, Ho TV, Grimes W, Ho HA, Park S, Wang S, Chai Y. BMP-SHH signaling network controls epithelial stem cell fate via regulation of its niche in the developing tooth. Dev Cell. 2015 Apr 20; 33(2):125-35. PMID: 25865348; PMCID: PMC4406846.
      24. Zhao H, Feng J, Ho TV, Grimes W, Urata M, Chai Y. The suture provides a niche for mesenchymal stem cells of craniofacial bones. Nat Cell Biol. 2015 Apr; 17(4):386-96. PMID: 25799059; PMCID: PMC4380556.
      25. Kim TH, Bae CH, Lee JY, Lee JC, Ko SO, Chai Y, Cho ES. Temporo-spatial requirement of Smad4 in dentin formation. Biochem Biophys Res Commun. 2015 Apr 17; 459(4):706-12. PMID: 25770424.
        View in: PubMed
      26. Ho TV, Iwata J, Ho HA, Grimes WC, Park S, Sanchez-Lara PA, Chai Y. Integration of comprehensive 3D microCT and signaling analysis reveals differential regulatory mechanisms of craniofacial bone development. Dev Biol. 2015 Apr 15; 400(2):180-90. PMID: 25722190; PMCID: PMC4385433.
      27. Shen WJ, Zhuo Y, Chai Y, Yang ZH, Han J, Yuan R. Enzyme-free electrochemical immunosensor based on host-guest nanonets catalyzing amplification for procalcitonin detection. ACS Appl Mater Interfaces. 2015 Feb 25; 7(7):4127-34. PMID: 25629216.
        View in: PubMed
      28. Zhong Z, Zhao H, Mayo J, Chai Y. Different requirements for Wnt signaling in tongue myogenic subpopulations. J Dent Res. 2015 Mar; 94(3):421-9. PMID: 25576472; PMCID: PMC4336158.
      29. Han J, Zhuo Y, Chai Y, Xiang Y, Yuan R. New type of redox nanoprobe: C60-based nanomaterial and its application in electrochemical immunoassay for doping detection. Anal Chem. 2015 Feb 03; 87(3):1669-75. PMID: 25547661.
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      30. Chai Y. Preface. Curr Top Dev Biol. 2015; 115:xix-xxi. PMID: 26589940.
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      31. Slavkin HC, Sanchez-Lara PA, Chai Y, Urata M. A model for interprofessional health care: lessons learned from craniofacial teams. J Calif Dent Assoc. 2014 Sep; 42(9):637-44. PMID: 25265730.
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      32. Han A, Zhao H, Li J, Pelikan R, Chai Y. ALK5-mediated transforming growth factor ß signaling in neural crest cells controls craniofacial muscle development via tissue-tissue interactions. Mol Cell Biol. 2014 Aug; 34(16):3120-31. PMID: 24912677; PMCID: PMC4135603.
      33. Zhao H, Feng J, Seidel K, Shi S, Klein O, Sharpe P, Chai Y. Secretion of shh by a neurovascular bundle niche supports mesenchymal stem cell homeostasis in the adult mouse incisor. Cell Stem Cell. 2014 Feb 06; 14(2):160-73. PMID: 24506883; PMCID: PMC3951379.
      34. Iwata J, Suzuki A, Yokota T, Ho TV, Pelikan R, Urata M, Sanchez-Lara PA, Chai Y. TGFß regulates epithelial-mesenchymal interactions through WNT signaling activity to control muscle development in the soft palate. Development. 2014 Feb; 141(4):909-17. PMID: 24496627; PMCID: PMC3912833.
      35. Zhang S, Tang C, Zhao Q, Li J, Yang L, Qie L, Fan X, Li L, Zhang N, Zhao M, Liu X, Chai Y, Zhang X, Wang H, Li Y, Li W, Zhi H, Jia G, Diao X. Development of highly polymorphic simple sequence repeat markers using genome-wide microsatellite variant analysis in Foxtail millet [Setaria italica (L.) P. Beauv]. BMC Genomics. 2014 Jan 28; 15:78. PMID: 24472631; PMCID: PMC3930901.
      36. Zhuo Y, Liao N, Chai Y, Gui GF, Zhao M, Han J, Xiang Y, Yuan R. Ultrasensitive apurinic/apyrimidinic endonuclease 1 immunosensing based on self-enhanced electrochemiluminescence of a Ru(II) complex. Anal Chem. 2014 Jan 21; 86(2):1053-60. PMID: 24328308.
        View in: PubMed
      37. Jia G, Shi S, Wang C, Niu Z, Chai Y, Zhi H, Diao X. Molecular diversity and population structure of Chinese green foxtail [Setaria viridis (L.) Beauv.] revealed by microsatellite analysis. J Exp Bot. 2013 Sep; 64(12):3645-56. PMID: 23956411.
        View in: PubMed
      38. Iwata J, Suzuki A, Pelikan RC, Ho TV, Sanchez-Lara PA, Chai Y. Modulation of lipid metabolic defects rescues cleft palate in Tgfbr2 mutant mice. Hum Mol Genet. 2014 Jan 01; 23(1):182-93. PMID: 23975680; PMCID: PMC3857953.
      39. Iwata J, Suzuki A, Pelikan RC, Ho TV, Chai Y. Noncanonical transforming growth factor ß (TGFß) signaling in cranial neural crest cells causes tongue muscle developmental defects. J Biol Chem. 2013 Oct 11; 288(41):29760-70. PMID: 23950180; PMCID: PMC3795273.
      40. Parada C, Li J, Iwata J, Suzuki A, Chai Y. CTGF mediates Smad-dependent transforming growth factor ß signaling to regulate mesenchymal cell proliferation during palate development. Mol Cell Biol. 2013 Sep; 33(17):3482-93. PMID: 23816882; PMCID: PMC3753855.
      41. Xie WB, Li Z, Shi N, Guo X, Tang J, Ju W, Han J, Liu T, Bottinger EP, Chai Y, Jose PA, Chen SY. Smad2 and myocardin-related transcription factor B cooperatively regulate vascular smooth muscle differentiation from neural crest cells. Circ Res. 2013 Sep 27; 113(8):e76-86. PMID: 23817199.
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      42. Jia G, Huang X, Zhi H, Zhao Y, Zhao Q, Li W, Chai Y, Yang L, Liu K, Lu H, Zhu C, Lu Y, Zhou C, Fan D, Weng Q, Guo Y, Huang T, Zhang L, Lu T, Feng Q, Hao H, Liu H, Lu P, Zhang N, Li Y, Guo E, Wang S, Wang S, Liu J, Zhang W, Chen G, Zhang B, Li W, Wang Y, Li H, Zhao B, Li J, Diao X, Han B. A haplotype map of genomic variations and genome-wide association studies of agronomic traits in foxtail millet (Setaria italica). Nat Genet. 2013 Aug; 45(8):957-61. PMID: 23793027.
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      43. Mima J, Koshino A, Oka K, Uchida H, Hieda Y, Nohara K, Kogo M, Chai Y, Sakai T. Regulation of the epithelial adhesion molecule CEACAM1 is important for palate formation. PLoS One. 2013; 8(4):e61653. PMID: 23613893; PMCID: PMC3629100.
      44. Gui G, Zhuo Y, Chai Y, Liao N, Zhao M, Han J, Zhu Q, Yuan R, Xiang Y. Supersandwich-type electrochemiluminescenct aptasensor based on Ru(phen)3(2+) functionalized hollow gold nanoparticles as signal-amplifying tags. Biosens Bioelectron. 2013 Sep 15; 47:524-9. PMID: 23643946.
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      45. Pelikan RC, Iwata J, Suzuki A, Chai Y, Hacia JG. Identification of candidate downstream targets of TGFß signaling during palate development by genome-wide transcript profiling. J Cell Biochem. 2013 Apr; 114(4):796-807. PMID: 23060211.
        View in: PubMed
      46. Song Z, Liu C, Iwata J, Gu S, Suzuki A, Sun C, He W, Shu R, Li L, Chai Y, Chen Y. Mice with Tak1 deficiency in neural crest lineage exhibit cleft palate associated with abnormal tongue development. J Biol Chem. 2013 Apr 12; 288(15):10440-50. PMID: 23460641; PMCID: PMC3624426.
      47. Liao N, Zhuo Y, Chai Y, Xiang Y, Han J, Yuan R. Reagentless electrochemiluminescent detection of protein biomarker using graphene-based magnetic nanoprobes and poly-L-lysine as co-reactant. Biosens Bioelectron. 2013 Jul 15; 45:189-94. PMID: 23500362.
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      48. Iwata J, Suzuki A, Pelikan RC, Ho TV, Sanchez-Lara PA, Urata M, Dixon MJ, Chai Y. Smad4-Irf6 genetic interaction and TGFß-mediated IRF6 signaling cascade are crucial for palatal fusion in mice. Development. 2013 Mar; 140(6):1220-30. PMID: 23406900; PMCID: PMC3585659.
      49. Huang XF, Chai Y. Molecular regulatory mechanism of tooth root development. Int J Oral Sci. 2012 Dec; 4(4):177-81. PMID: 23222990; PMCID: PMC3633063.
      50. Wang C, Jia G, Zhi H, Niu Z, Chai Y, Li W, Wang Y, Li H, Lu P, Zhao B, Diao X. Genetic diversity and population structure of Chinese foxtail millet [Setaria italica (L.) Beauv.] landraces. G3 (Bethesda). 2012 Jul; 2(7):769-77. PMID: 22870400.
        View in: PubMed
      51. Parada C, Chai Y. Roles of BMP signaling pathway in lip and palate development. Front Oral Biol. 2012; 16:60-70. PMID: 22759670; PMCID: PMC3661199.
      52. Stephens H, Jensen B, Carpiaux W, Sedghizadeh P, Chai Y. A collaborative approach to advance student research at the University of Southern California. J Calif Dent Assoc. 2012 May; 40(5):433-6, 438-9. PMID: 22685951.
        View in: PubMed
      53. Han D, Zhao H, Parada C, Hacia JG, Bringas P, Chai Y. A TGFß-Smad4-Fgf6 signaling cascade controls myogenic differentiation and myoblast fusion during tongue development. Development. 2012 May; 139(9):1640-50. PMID: 22438570; PMCID: PMC3317969.
      54. Iwata J, Hacia JG, Suzuki A, Sanchez-Lara PA, Urata M, Chai Y. Modulation of noncanonical TGF-ß signaling prevents cleft palate in Tgfbr2 mutant mice. J Clin Invest. 2012 Mar; 122(3):873-85. PMID: 22326956; PMCID: PMC3287237.
      55. Parada C, Han D, Chai Y. Molecular and cellular regulatory mechanisms of tongue myogenesis. J Dent Res. 2012 Jun; 91(6):528-35. PMID: 22219210; PMCID: PMC3348065.
      56. Iwata J, Tung L, Urata M, Hacia JG, Pelikan R, Suzuki A, Ramenzoni L, Chaudhry O, Parada C, Sanchez-Lara PA, Chai Y. Fibroblast growth factor 9 (FGF9)-pituitary homeobox 2 (PITX2) pathway mediates transforming growth factor ß (TGFß) signaling to regulate cell proliferation in palatal mesenchyme during mouse palatogenesis. J Biol Chem. 2012 Jan 20; 287(4):2353-63. PMID: 22123828; PMCID: PMC3268397.
      57. Han J, Zhuo Y, Chai Y, Yuan YL, Yuan R. Novel electrochemical catalysis as signal amplified strategy for label-free detection of neuron-specific enolase. Biosens Bioelectron. 2012 Jan 15; 31(1):399-405. PMID: 22169815.
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      58. Hung Y, Huang X, Chai Y. Molecular regulatory mechanism of root development. J Calif Dent Assoc. 2011 May; 39(5):321-4. PMID: 21721476.
        View in: PubMed
      59. Li J, Huang X, Xu X, Mayo J, Bringas P, Jiang R, Wang S, Chai Y. SMAD4-mediated WNT signaling controls the fate of cranial neural crest cells during tooth morphogenesis. Development. 2011 May; 138(10):1977-89. PMID: 21490069; PMCID: PMC3082303.
      60. Hochheiser H, Aronow BJ, Artinger K, Beaty TH, Brinkley JF, Chai Y, Clouthier D, Cunningham ML, Dixon M, Donahue LR, Fraser SE, Hallgrimsson B, Iwata J, Klein O, Marazita ML, Murray JC, Murray S, de Villena FP, Postlethwait J, Potter S, Shapiro L, Spritz R, Visel A, Weinberg SM, Trainor PA. The FaceBase Consortium: a comprehensive program to facilitate craniofacial research. Dev Biol. 2011 Jul 15; 355(2):175-82. PMID: 21458441; PMCID: PMC3440302.
      61. Han J, Zhuo Y, Chai Y, Mao L, Yuan YL, Yuan R. Highly conducting gold nanoparticles-graphene nanohybrid films for ultrasensitive detection of carcinoembryonic antigen. Talanta. 2011 Jul 15; 85(1):130-5. PMID: 21645681.
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      62. Zhao H, Li S, Han D, Kaartinen V, Chai Y. Alk5-mediated transforming growth factor ß signaling acts upstream of fibroblast growth factor 10 to regulate the proliferation and maintenance of dental epithelial stem cells. Mol Cell Biol. 2011 May; 31(10):2079-89. PMID: 21402782; PMCID: PMC3133354.
      63. Iwata J, Parada C, Chai Y. The mechanism of TGF-ß signaling during palate development. Oral Dis. 2011 Nov; 17(8):733-44. PMID: 21395922; PMCID: PMC3329177.
      64. Zhuo Y, Chai Y, Yuan R, Mao L, Yuan YL, Han J. Glucose oxidase and ferrocene labels immobilized at Au/TiO2 nanocomposites with high load amount and activity for sensitive immunoelectrochemical measurement of ProGRP biomarker. Biosens Bioelectron. 2011 May 15; 26(9):3838-44. PMID: 21429733.
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      65. Chung IH, Han J, Iwata J, Chai Y. Msx1 and Dlx5 function synergistically to regulate frontal bone development. Genesis. 2010 Nov; 48(11):645-55. PMID: 20824629; PMCID: PMC2995851.
      66. Jinno H, Morozova O, Jones KL, Biernaskie JA, Paris M, Hosokawa R, Rudnicki MA, Chai Y, Rossi F, Marra MA, Miller FD. Convergent genesis of an adult neural crest-like dermal stem cell from distinct developmental origins. Stem Cells. 2010 Nov; 28(11):2027-40. PMID: 20848654; PMCID: PMC3087810.
      67. He F, Xiong W, Wang Y, Matsui M, Yu X, Chai Y, Klingensmith J, Chen Y. Modulation of BMP signaling by Noggin is required for the maintenance of palatal epithelial integrity during palatogenesis. Dev Biol. 2010 Nov 01; 347(1):109-21. PMID: 20727875; PMCID: PMC3010875.
      68. Huang X, Xu X, Bringas P, Hung YP, Chai Y. Smad4-Shh-Nfic signaling cascade-mediated epithelial-mesenchymal interaction is crucial in regulating tooth root development. J Bone Miner Res. 2010 May; 25(5):1167-78. PMID: 19888897; PMCID: PMC3153373.
      69. Lu L, Wang J, Zhang F, Chai Y, Brand D, Wang X, Horwitz DA, Shi W, Zheng SG. Role of SMAD and non-SMAD signals in the development of Th17 and regulatory T cells. J Immunol. 2010 Apr 15; 184(8):4295-306. PMID: 20304828; PMCID: PMC3087811.
      70. Hosokawa R, Oka K, Yamaza T, Iwata J, Urata M, Xu X, Bringas P, Nonaka K, Chai Y. TGF-beta mediated FGF10 signaling in cranial neural crest cells controls development of myogenic progenitor cells through tissue-tissue interactions during tongue morphogenesis. Dev Biol. 2010 May 01; 341(1):186-95. PMID: 20193675; PMCID: PMC3336866.
      71. Chai Y. Towards a molecular understanding of cleft palate. Beijing Da Xue Xue Bao. 2010 Feb 18; 42(1):9-13. PMID: 20429146.
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      72. Huang XF, Chai Y. TGF-ß signalling and tooth development. Chin J Dent Res. 2010; 13(1):7-15. PMID: 20936186.
        View in: PubMed
      73. Iwata J, Hosokawa R, Sanchez-Lara PA, Urata M, Slavkin H, Chai Y. Transforming growth factor-beta regulates basal transcriptional regulatory machinery to control cell proliferation and differentiation in cranial neural crest-derived osteoprogenitor cells. J Biol Chem. 2010 Feb 12; 285(7):4975-82. PMID: 19959467; PMCID: PMC2836101.
      74. Han J, Mayo J, Xu X, Li J, Bringas P, Maas RL, Rubenstein JL, Chai Y. Indirect modulation of Shh signaling by Dlx5 affects the oral-nasal patterning of palate and rescues cleft palate in Msx1-null mice. Development. 2009 Dec; 136(24):4225-33. PMID: 19934017; PMCID: PMC2781056.
      75. Huang X, Bringas P, Slavkin HC, Chai Y. Fate of HERS during tooth root development. Dev Biol. 2009 Oct 01; 334(1):22-30. PMID: 19576204; PMCID: PMC2744848.
      76. Hosokawa R, Deng X, Takamori K, Xu X, Urata M, Bringas P, Chai Y. Epithelial-specific requirement of FGFR2 signaling during tooth and palate development. J Exp Zool B Mol Dev Evol. 2009 Jun 15; 312B(4):343-50. PMID: 19235875; PMCID: PMC2896559.
      77. Wang H, Chai Y, Chu X, Zhao Y, Wu Y, Zhao J, Ngezahayo F, Xu C, Liu B. Molecular characterization of a rice mutator-phenotype derived from an incompatible cross-pollination reveals transgenerational mobilization of multiple transposable elements and extensive epigenetic instability. BMC Plant Biol. 2009 May 29; 9:63. PMID: 19476655; PMCID: PMC2696445.
      78. Noh T, Gabet Y, Cogan J, Shi Y, Tank A, Sasaki T, Criswell B, Dixon A, Lee C, Tam J, Kohler T, Segev E, Kockeritz L, Woodgett J, Müller R, Chai Y, Smith E, Bab I, Frenkel B. Lef1 haploinsufficient mice display a low turnover and low bone mass phenotype in a gender- and age-specific manner. PLoS One. 2009; 4(5):e5438. PMID: 19412553; PMCID: PMC2673053.
      79. Chung IH, Yamaza T, Zhao H, Choung PH, Shi S, Chai Y. Stem cell property of postmigratory cranial neural crest cells and their utility in alveolar bone regeneration and tooth development. Stem Cells. 2009 Apr; 27(4):866-77. PMID: 19350689; PMCID: PMC2896558.
      80. Shi S, Chai Y, Slavkin H. Emerging opportunities for the next generation of dental implants? Dent Today. 2009 Mar; 28(3):98-9. PMID: 19323323.
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      81. Zhang Z, Lan Y, Chai Y, Jiang R. Antagonistic actions of Msx1 and Osr2 pattern mammalian teeth into a single row. Science. 2009 Feb 27; 323(5918):1232-4. PMID: 19251632; PMCID: PMC2650836.
      82. Xu X, Han J, Ito Y, Bringas P, Deng C, Chai Y. Ectodermal Smad4 and p38 MAPK are functionally redundant in mediating TGF-beta/BMP signaling during tooth and palate development. Dev Cell. 2008 Aug; 15(2):322-9. PMID: 18694570; PMCID: PMC2610417.
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