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    Troy A. McEachron

    TitleAssistant Professor of Research Translational Genomics
    SchoolKeck School of Medicine of USC
    DepartmentDepartment of Translational Genomics
    AddressNRT 1450 Biggy St.
    Health Sciences Campus
    Los Angeles California 90089-9601
    Phone+1 323 442 6049
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      Collapse Overview 
      Collapse Overview
      My research focuses on two separate yet complimentary areas: (1) the utilization of next generation genomic, transcriptomic, and proteomic technologies to profile recurrent and/or refractory pediatric, adolescent, and young adult (AYA) cancer patients for clinical decision making; (2) the use of functional genomics to identify and interrogate the developmental and therapeutic aspects of sarcomas that predominantly arise in the pediatric and AYA populations. My overall research interests are a reflection of my diverse training history. My training background in basic science includes the molecular dissection of autocrine and paracrine signaling mechanisms between tumor and host using in vitro and in vivo models and the characterization of genetically engineered mouse models of pediatric brain tumors. Additionally, my translational science training includes the interpretation and functional validation next generation sequencing data from recurrent/refractory pediatric cancer patients.

      Over time I have gained an immense interest in rhabdomyosarcomas (RMS), desmoplastic small round cell tumors (DSRCT), Ewing sarcomas (EWS), and clear cell sarcomas (CCS). The relatively low mutation burden in numerous different types of sarcomas suggests that there are transcriptional and/or epigenetic mechanisms that drive these diseases. This is inline with recent studies suggesting that epigenetic dysregulation and altered developmental programing drive many pediatric malignancies. Moreover, the mechanisms by which sarcoma-specific oncogenic fusion genes initiate and/or sustain disease remains elusive. My laboratory is dedicated to developing new biological tools and approaches to enable a functional genomics inquiry into these mechanisms as to reveal insight into the underlying biology of these sarcomas. Additionally, we will interrogate patient derived material to better define the molecular characteristics of different sarcoma subtypes to enable more precise treatment strategies for these difficult diseases.


      Collapse Biography 
      Collapse Awards and Honors
      Translational Genomics Research Institute (TGen)2014Honorary Delegate, Society for Adolescent and Young Adult Oncology Annual Meeting
      Translational Genomics Research Institute (TGen)2012  - 2014UNCF/Merck Postdoctoral Science Research Fellowship
      University of North Carolina at Chapel Hill2009  - 2011Ruth L. Kirschstein National Research Service Award for Individual Pre-Doctoral Fellowships (F31)
      University of North Carolina at Chapel Hill2008Carl Storm Minority Fellowship Award
      University of North Carolina at Chapel Hill2009AACR Minority Scholar in Cancer Research

      Collapse ORNG Applications 
      Collapse In The News

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. McEachron T, Sender LS, Zabokrtsky KB, Kaltenecker B, Holmes WN, Cherni I, Manojlovic Z, Liao SY, Craig DW, Carpten JD, Torno LR. Molecular Genetic Profiling of Adolescent Glassy Cell Carcinoma of the Cervix Reveals Targetable EGFR Amplification with Potential Therapeutic Implications. J Adolesc Young Adult Oncol. 2016 Sep; 5(3):297-302. PMID: 26974246.
        View in: PubMed
      2. McEachron T, Kirov I, Wungwattana M, Cortes D, Zabokrtsky KB, Sassoon A, Craig D, Carpten JD, Sender LS. Successful Treatment of Genetically Profiled Pediatric Extranodal NK/T-Cell Lymphoma Targeting Oncogenic STAT3 Mutation. Pediatr Blood Cancer. 2016 Apr; 63(4):727-30. PMID: 26727971.
        View in: PubMed
      3. Liu X, McEachron T, Schwartzentruber J, Wu G. Histone H3 mutations in pediatric brain tumors. Cold Spring Harb Perspect Biol. 2014 Apr 01; 6(4):a018689. PMID: 24691963; PMCID: PMC3970419.
      4. Ramos P, Karnezis AN, Craig DW, Sekulic A, Russell ML, Hendricks WP, Corneveaux JJ, Barrett MT, Shumansky K, Yang Y, Shah SP, Prentice LM, Marra MA, Kiefer J, Zismann VL, McEachron T, Salhia B, Prat J, D'Angelo E, Clarke BA, Pressey JG, Farley JH, Anthony SP, Roden RB, Cunliffe HE, Huntsman DG, Trent JM. Small cell carcinoma of the ovary, hypercalcemic type, displays frequent inactivating germline and somatic mutations in SMARCA4. Nat Genet. 2014 May; 46(5):427-9. PMID: 24658001; PMCID: PMC4332808.
      5. McEachron T, Tomboc P, Tran NL. An integrated approach to identifying clinically relevant targets in pediatric gliomas. CNS Oncol. 2013 Jul; 2(4):303-6. PMID: 25054574.
        View in: PubMed
      6. Kasthuri RS, Glover SL, Jonas W, McEachron T, Pawlinski R, Arepally GM, Key NS, Mackman N. PF4/heparin-antibody complex induces monocyte tissue factor expression and release of tissue factor positive microparticles by activation of Fc?RI. Blood. 2012 May 31; 119(22):5285-93. PMID: 22394597; PMCID: PMC3369617.
      7. Wu G, Broniscer A, McEachron T, Lu C, Paugh BS, Becksfort J, Qu C, Ding L, Huether R, Parker M, Zhang J, Gajjar A, Dyer MA, Mullighan CG, Gilbertson RJ, Mardis ER, Wilson RK, Downing JR, Ellison DW, Zhang J, Baker SJ. Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas. Nat Genet. 2012 Jan 29; 44(3):251-3. PMID: 22286216; PMCID: PMC3288377.
      8. McEachron T, Church FC, Mackman N. Regulation of thrombin-induced plasminogen activator inhibitor-1 in 4T1 murine breast cancer cells. Blood Coagul Fibrinolysis. 2011 Oct; 22(7):576-82. PMID: 21799402.
        View in: PubMed
      9. McEachron T, Pawlinski R, Richards KL, Church FC, Mackman N. Protease-activated receptors mediate crosstalk between coagulation and fibrinolysis. Blood. 2010 Dec 02; 116(23):5037-44. PMID: 20736455; PMCID: PMC3012597.
      10. McEachron T, Mackman N. Tumors, ticks and tissue factor. J Thromb Haemost. 2009 Nov; 7(11):1852-4. PMID: 19694942; PMCID: PMC2834282.