Tobias S Ulmer, PhD

Title(s)Associate Professor of Physiology and Neuroscience
SchoolKeck School of Medicine of Usc
AddressZNI 111, 1501 San Pablo Street
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 4326
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    Dr. Ulmer received his PhD from the University of Oxford after completing his undergraduate work at the University of Zurich. After completing postdoctoral work at NIH, Dr. Ulmer establishes his research group at the University of Southern California (USC).

    His research program centers on elucidating the molecular mechanism underlying physiological function and pathological dysfunction, respectively, of biological processes at atomic resolution. Specifically, the three-dimensional structure of proteins, their dynamics as well as protein-protein and protein-lipid interactions are determined. As a principal research tool, high-resolution, multidimensional solution-state nuclear magnetic resonance (NMR) spectroscopy is employed. His overarching interest is devoted to the structural biology of proteins that are either membrane embedded or membrane surface-bound.

    Specifically, his laboratory focuses on understanding
    (1) the structural basis of transmembrane signaling in cell surface receptors, and
    (2) the mechanism of carnitine palmitoyltransferase 1 regulation.

    Collapse Research 
    Collapse Research Activities and Funding
    Mechanism of CD33 receptor signaling in Alzheimer disease
    NIH RF1AG072442May 15, 2021 - Apr 30, 2024
    Role: Principal Investigator
    Structural basis of CD33 receptor signaling in Alzheimer's disease
    NIH R03AG063284Apr 1, 2019 - Jan 31, 2021
    Role: Principal Investigator
    Mechanisms of Integrin Receptor Transmembrane Signaling
    NIH R01HL089726Apr 15, 2008 - Mar 31, 2014
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Faculty Mentoring

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Correction: Evolutionarily conserved dual lysine motif determines the non-chaperone function of secreted Hsp90alpha in tumour progression. Oncogene. 2024 Apr 04. Zou M, Bhatia A, Dong H, Jayaprakash P, Guo J, Sahu D, Hou Y, Tsen F, Tong C, O'Brien K, Situ AJ, Schmidt T, Chen M, Ying Q, Ulmer TS, Woodley DT, Li W. PMID: 38575761.
      View in: PubMed   Mentions:    Fields:    
    2. VprBP/DCAF1 Triggers Melanomagenic Gene Silencing through Histone H2A Phosphorylation. Biomedicines. 2023 Sep 17; 11(9). Shin Y, Kim S, Liang G, Ulmer TS, An W. PMID: 37760992; PMCID: PMC10526264.
      View in: PubMed   Mentions:
    3. VprBP/DCAF1 triggers melanomagenic gene silencing through histone H2A phosphorylation. Res Sq. 2023 Jul 12. Shin Y, Kim S, Liang G, Ulmer TS, An W. PMID: 37293029; PMCID: PMC10246234.
      View in: PubMed   Mentions:
    4. Comparison of Integrin αIIbβ3 Transmembrane Association in Vesicles and Bicelles. Biochemistry. 2023 06 20; 62(12):1858-1863. Situ AJ, Ulmer TS. PMID: 37279176.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    5. Phosphorylation and stabilization of EZH2 by DCAF1/VprBP trigger aberrant gene silencing in colon cancer. Nat Commun. 2023 04 17; 14(1):2140. Ghate NB, Kim S, Shin Y, Kim J, Doche M, Valena S, Situ A, Kim S, Rhie SK, Lenz HJ, Ulmer TS, Mumenthaler SM, An W. PMID: 37069142; PMCID: PMC10110550.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    6. Molecular basis of Q-length selectivity for the MW1 antibody-huntingtin interaction. J Biol Chem. 2023 04; 299(4):104616. Bravo-Arredondo JM, Venkataraman R, Varkey J, Isas JM, Situ AJ, Xu H, Chen J, Ulmer TS, Langen R. PMID: 36931390; PMCID: PMC10124945.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    7. Insight Into Pathological Integrin αIIbβ3 Activation From Safeguarding The Inactive State. J Mol Biol. 2021 04 02; 433(7):166832. Situ AJ, Kim J, An W, Kim C, Ulmer TS. PMID: 33539882.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    8. Isothermal Titration Calorimetry of Membrane Proteins. Methods Mol Biol. 2021; 2302:69-79. Vu HN, Situ AJ, Ulmer TS. PMID: 33877623.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    9. Topological Adaptation of Transmembrane Domains to the Force-Modulated Lipid Bilayer Is a Basis of Sensing Mechanical Force. Curr Biol. 2020 Jul 06; 30(13):2649. Kim J, Lee J, Jang J, Ye F, Hong SJ, Petrich BG, Ulmer TS, Kim C. PMID: 32634408; PMCID: PMC7402398.
      View in: PubMed   Mentions: 1     Fields:    
    10. Topological Adaptation of Transmembrane Domains to the Force-Modulated Lipid Bilayer Is a Basis of Sensing Mechanical Force. Curr Biol. 2020 05 04; 30(9):1614-1625.e5. Kim J, Lee J, Jang J, Ye F, Hong SJ, Petrich BG, Ulmer TS, Kim C. PMID: 32169208; PMCID: PMC7202955.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    11. Universal principles of membrane protein assembly, composition and evolution. PLoS One. 2019; 14(8):e0221372. Situ AJ, Ulmer TS. PMID: 31415673; PMCID: PMC6695178.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    12. p32 is a negative regulator of p53 tetramerization and transactivation. Mol Oncol. 2019 09; 13(9):1976-1992. Ghate NB, Kim J, Shin Y, Situ A, Ulmer TS, An W. PMID: 31293051; PMCID: PMC6717765.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    13. The folding equilibrium of huntingtin exon 1 monomer depends on its polyglutamine tract. J Biol Chem. 2018 12 21; 293(51):19613-19623. Bravo-Arredondo JM, Kegulian NC, Schmidt T, Pandey NK, Situ AJ, Ulmer TS, Langen R. PMID: 30315108; PMCID: PMC6314148.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    14. Regulation of Breast Cancer-Induced Osteoclastogenesis by MacroH2A1.2 Involving EZH2-Mediated H3K27me3. Cell Rep. 2018 07 03; 24(1):224-237. Kim J, Shin Y, Lee S, Kim M, Punj V, Lu JF, Shin H, Kim K, Ulmer TS, Koh J, Jeong D, An W. PMID: 29972783; PMCID: PMC6061927.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    15. H3K27me1 is essential for MMP-9-dependent H3N-terminal tail proteolysis during osteoclastogenesis. Epigenetics Chromatin. 2018 05 28; 11(1):23. Kim K, Shin Y, Kim J, Ulmer TS, An W. PMID: 29807539; PMCID: PMC5971420.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    16. Membrane Anchoring of α-Helical Proteins: Role of Tryptophan. J Phys Chem B. 2018 01 25; 122(3):1185-1194. Situ AJ, Kang SM, Frey BB, An W, Kim C, Ulmer TS. PMID: 29323921.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    17. Direct Evaluation of Protein-Lipid Contacts Reveals Protein Membrane Immersion and Isotropic Bicelle Structure. J Phys Chem Lett. 2016 Nov 03; 7(21):4420-4426. Schmidt T, Situ AJ, Ulmer TS. PMID: 27776216.
      View in: PubMed   Mentions: 2     Fields:    
    18. Evolutionarily conserved dual lysine motif determines the non-chaperone function of secreted Hsp90alpha in tumour progression. Oncogene. 2017 04; 36(15):2160-2171. Zou M, Bhatia A, Dong H, Jayaprakash P, Guo J, Sahu D, Hou Y, Tsen F, Tong C, O'Brien K, Situ AJ, Schmidt T, Chen M, Ying Q, Ulmer TS, Woodley DT, Li W. PMID: 27721406; PMCID: PMC5386837.
      View in: PubMed   Mentions: 33     Fields:    
    19. Structural and thermodynamic basis of proline-induced transmembrane complex stabilization. Sci Rep. 2016 07 20; 6:29809. Schmidt T, Situ AJ, Ulmer TS. PMID: 27436065; PMCID: PMC4951694.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    20. A Conserved Ectodomain-Transmembrane Domain Linker Motif Tunes the Allosteric Regulation of Cell Surface Receptors. J Biol Chem. 2016 08 19; 291(34):17536-46. Schmidt T, Ye F, Situ AJ, An W, Ginsberg MH, Ulmer TS. PMID: 27365391; PMCID: PMC5016151.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    21. MMP-9 facilitates selective proteolysis of the histone H3 tail at genes necessary for proficient osteoclastogenesis. Genes Dev. 2016 Jan 15; 30(2):208-19. Kim K, Punj V, Kim JM, Lee S, Ulmer TS, Lu W, Rice JC, An W. PMID: 26744418; PMCID: PMC4719310.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    22. Linker histone H1.2 establishes chromatin compaction and gene silencing through recognition of H3K27me3. Sci Rep. 2015 Nov 19; 5:16714. Kim JM, Kim K, Punj V, Liang G, Ulmer TS, Lu W, An W. PMID: 26581166; PMCID: PMC4652225.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    23. Cooperation between SMYD3 and PC4 drives a distinct transcriptional program in cancer cells. Nucleic Acids Res. 2015 Oct 15; 43(18):8868-83. Kim JM, Kim K, Schmidt T, Punj V, Tucker H, Rice JC, Ulmer TS, An W. PMID: 26350217; PMCID: PMC4605318.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansCells
    24. Mutation in CPT1C Associated With Pure Autosomal Dominant Spastic Paraplegia. JAMA Neurol. 2015 May; 72(5):561-70. Rinaldi C, Schmidt T, Situ AJ, Johnson JO, Lee PR, Chen KL, Bott LC, Fadó R, Harmison GH, Parodi S, Grunseich C, Renvoisé B, Biesecker LG, De Michele G, Santorelli FM, Filla A, Stevanin G, Dürr A, Brice A, Casals N, Traynor BJ, Blackstone C, Ulmer TS, Fischbeck KH. PMID: 25751282; PMCID: PMC5612424.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimals
    25. Annular anionic lipids stabilize the integrin αIIbβ3 transmembrane complex. J Biol Chem. 2015 Mar 27; 290(13):8283-93. Schmidt T, Suk JE, Ye F, Situ AJ, Mazumder P, Ginsberg MH, Ulmer TS. PMID: 25632962; PMCID: PMC4375483.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    26. Characterization of membrane protein interactions by isothermal titration calorimetry. J Mol Biol. 2014 Oct 23; 426(21):3670-80. Situ AJ, Schmidt T, Mazumder P, Ulmer TS. PMID: 25178257.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    27. Structural characterization of the regulatory domain of brain carnitine palmitoyltransferase 1. Biopolymers. 2014 Apr; 101(4):398-405. Samanta S, Situ AJ, Ulmer TS. PMID: 24037959; PMCID: PMC3907070.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    28. Sequence and membrane determinants of the random coil-helix transition of α-synuclein. J Mol Biol. 2014 May 15; 426(10):2130-44. Lokappa SB, Suk JE, Balasubramanian A, Samanta S, Situ AJ, Ulmer TS. PMID: 24607710.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    29. Insight into α-synuclein plasticity and misfolding from differential micelle binding. J Phys Chem B. 2013 Oct 03; 117(39):11448-59. Mazumder P, Suk JE, Ulmer TS. PMID: 23978162; PMCID: PMC3946565.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    30. Construction of covalent membrane protein complexes and high-throughput selection of membrane mimics. J Am Chem Soc. 2012 Jun 06; 134(22):9030-3. Suk JE, Situ AJ, Ulmer TS. PMID: 22626249; PMCID: PMC3415561.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    31. A potentially common peptide target in secreted heat shock protein-90α for hypoxia-inducible factor-1α-positive tumors. Mol Biol Cell. 2012 Feb; 23(4):602-13. Sahu D, Zhao Z, Tsen F, Cheng CF, Park R, Situ AJ, Dai J, Eginli A, Shams S, Chen M, Ulmer TS, Conti P, Woodley DT, Li W. PMID: 22190738; PMCID: PMC3279389.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    32. Basic amino-acid side chains regulate transmembrane integrin signalling. Nature. 2011 Dec 18; 481(7380):209-13. Kim C, Schmidt T, Cho EG, Ye F, Ulmer TS, Ginsberg MH. PMID: 22178926; PMCID: PMC3257387.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    33. Recognition of enhancer element-specific histone methylation by TIP60 in transcriptional activation. Nat Struct Mol Biol. 2011 Nov 13; 18(12):1358-65. Jeong KW, Kim K, Situ AJ, Ulmer TS, An W, Stallcup MR. PMID: 22081016; PMCID: PMC3230772.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansCells
    34. An environment-dependent structural switch underlies the regulation of carnitine palmitoyltransferase 1A. J Biol Chem. 2011 Dec 09; 286(49):42545-42554. Rao JN, Warren GZL, Estolt-Povedano S, Zammit VA, Ulmer TS. PMID: 21990363; PMCID: PMC3234983.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    35. Alpha-synuclein populates both elongated and broken helix states on small unilamellar vesicles. J Biol Chem. 2011 Jun 17; 286(24):21450-7. Lokappa SB, Ulmer TS. PMID: 21524999; PMCID: PMC3122204.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansCells
    36. A combinatorial NMR and EPR approach for evaluating the structural ensemble of partially folded proteins. J Am Chem Soc. 2010 Jun 30; 132(25):8657-68. Rao JN, Jao CC, Hegde BG, Langen R, Ulmer TS. PMID: 20524659; PMCID: PMC2903201.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansCells
    37. Structural basis of transmembrane domain interactions in integrin signaling. Cell Adh Migr. 2010 Apr-Jun; 4(2):243-8. Ulmer TS. PMID: 20168080; PMCID: PMC2900621.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    38. The clustering and spatial arrangement of beta-sheet sequence, but not order, govern alpha-synuclein fibrillogenesis. Biochemistry. 2010 Feb 23; 49(7):1533-40. Suk JE, Lokappa SB, Ulmer TS. PMID: 20121219; PMCID: PMC2841006.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    39. Effect of pseudorepeat rearrangement on alpha-synuclein misfolding, vesicle binding, and micelle binding. J Mol Biol. 2009 Jul 17; 390(3):516-29. Rao JN, Kim YE, Park LS, Ulmer TS. PMID: 19481090; PMCID: PMC2731582.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    40. The structure of the integrin alphaIIbbeta3 transmembrane complex explains integrin transmembrane signalling. EMBO J. 2009 May 06; 28(9):1351-61. Lau TL, Kim C, Ginsberg MH, Ulmer TS. PMID: 19279667; PMCID: PMC2683045.
      View in: PubMed   Mentions: 176     Fields:    Translation:HumansCells
    41. Interactions of platelet integrin alphaIIb and beta3 transmembrane domains in mammalian cell membranes and their role in integrin activation. Blood. 2009 May 07; 113(19):4747-53. Kim C, Lau TL, Ulmer TS, Ginsberg MH. PMID: 19218549; PMCID: PMC2680374.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    42. Structure of the integrin alphaIIb transmembrane segment. J Biol Chem. 2008 Jun 06; 283(23):16162-8. Lau TL, Dua V, Ulmer TS. PMID: 18417472; PMCID: PMC3259656.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    43. Characterization of alpha-synuclein interactions with selected aggregation-inhibiting small molecules. Biochemistry. 2008 Apr 22; 47(16):4651-6. Rao JN, Dua V, Ulmer TS. PMID: 18366183.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    44. Structure of the integrin beta3 transmembrane segment in phospholipid bicelles and detergent micelles. Biochemistry. 2008 Apr 01; 47(13):4008-16. Lau TL, Partridge AW, Ginsberg MH, Ulmer TS. PMID: 18321071.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansCells
    45. Insight into disulfide bond catalysis in Chlamydia from the structure and function of DsbH, a novel oxidoreductase. J Biol Chem. 2008 Jan 11; 283(2):824-32. Mac TT, von Hacht A, Hung KC, Dutton RJ, Boyd D, Bardwell JC, Ulmer TS. PMID: 18003611.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    46. NMR assignment of the periplasmic oxidoreductase DsbH from Chlamydia. Biomol NMR Assign. 2007 Dec; 1(2):195-6. Hung KC, Mac TT, Ulmer TS. PMID: 19636863.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    47. Comparison of structure and dynamics of micelle-bound human alpha-synuclein and Parkinson disease variants. J Biol Chem. 2005 Dec 30; 280(52):43179-87. Ulmer TS, Bax A. PMID: 16166095.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansCells
    48. Structure and dynamics of micelle-bound human alpha-synuclein. J Biol Chem. 2005 Mar 11; 280(10):9595-603. Ulmer TS, Bax A, Cole NB, Nussbaum RL. PMID: 15615727.
      View in: PubMed   Mentions: 417     Fields:    Translation:HumansCells
    49. Quantitative J correlation methods for the accurate measurement of 13C'-13Calpha dipolar couplings in proteins. J Biomol NMR. 2004 Oct; 30(2):181-94. Jaroniec CP, Ulmer TS, Bax A. PMID: 15666562.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    50. Amide proton relaxation measurements employing a highly deuterated protein. J Magn Reson. 2004 Feb; 166(2):190-201. Ulmer TS, Campbell ID, Boyd J. PMID: 14729031.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    51. Evaluation of backbone proton positions and dynamics in a small protein by liquid crystal NMR spectroscopy. J Am Chem Soc. 2003 Jul 30; 125(30):9179-91. Ulmer TS, Ramirez BE, Delaglio F, Bax A. PMID: 15369375.
      View in: PubMed   Mentions: 126     Fields:    Translation:Cells
    52. Domain-specific interactions of talin with the membrane-proximal region of the integrin beta3 subunit. Biochemistry. 2003 Jul 15; 42(27):8307-12. Ulmer TS, Calderwood DA, Ginsberg MH, Campbell ID. PMID: 12846579.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    53. Calcium dependence of the interaction between calmodulin and anthrax edema factor. J Biol Chem. 2003 Aug 01; 278(31):29261-6. Ulmer TS, Soelaiman S, Li S, Klee CB, Tang WJ, Bax A. PMID: 12724328.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    54. Structural determinants of integrin recognition by talin. Mol Cell. 2003 Jan; 11(1):49-58. García-Alvarez B, de Pereda JM, Calderwood DA, Ulmer TS, Critchley D, Campbell ID, Ginsberg MH, Liddington RC. PMID: 12535520.
      View in: PubMed   Mentions: 218     Fields:    Translation:AnimalsCells
    55. SH3-SH2 domain orientation in Src kinases: NMR studies of Fyn. Structure. 2002 Jul; 10(7):901-11. Ulmer TS, Werner JM, Campbell ID. PMID: 12121645.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    56. NMR analysis of structure and dynamics of the cytosolic tails of integrin alpha IIb beta 3 in aqueous solution. Biochemistry. 2001 Jun 26; 40(25):7498-508. Ulmer TS, Yaspan B, Ginsberg MH, Campbell ID. PMID: 11412103.
      View in: PubMed   Mentions: 42     Fields:    Translation:Cells
    57. A membrane-distal segment of the integrin alpha IIb cytoplasmic domain regulates integrin activation. J Biol Chem. 2001 Jun 22; 276(25):22514-21. Ginsberg MH, Yaspan B, Forsyth J, Ulmer TS, Campbell ID, Slepak M. PMID: 11304543.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    58. The role of the Src homology 3-Src homology 2 interface in the regulation of Src kinases. J Biol Chem. 2001 May 18; 276(20):17199-205. Arold ST, Ulmer TS, Mulhern TD, Werner JM, Ladbury JE, Campbell ID, Noble ME. PMID: 11278857.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
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