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    Sebastien G. Bouret, PhD

    TitleAssociate Professor of Pediatrics
    SchoolKeck School of Medicine of USC
    DepartmentPediatrics
    AddressCHL Mail Stop 135
    Off Campus
    Los Angeles California 90089
    Phone+1 323 361 8743

       Overview 
       Overview
      The long-range goal of the Bouret's lab is to study the hormonal and molecular signals that direct development of brain feeding circuits. Research in the Bouret’s lab has directly led to several breakthroughs in the understanding of the complex hormonal signals and neurodevelopmental substrates responsible for appetite regulation. Most notably, we found that metabolic hormones (such as leptin and ghrelin) influence the development and architecture of hypothalamic circuits involved in energy balance regulation. More recently, our lab has discovered a role for autophagy (a cellular process that degrades cytoplasmic materials, including organelles and misfolded proteins) in hypothalamic development and metabolic regulation.

      Our current research projects aim at examining the cellular (e.g., ER stress and autophagy) and molecular (e.g., miRNAs, axon guidance cues) events involved in hypothalamic development and lifelong metabolic regulation. Our current research goal is also to study the molecular signals that link nmaternal obesity and the abnormal development of hypothalamic feeding circuits.


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       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Johnson MD, Bouret SG, Dunn-Meynell AA, Boyle CN, Lutz TA, Levin BE. Early postnatal amylin treatment enhances hypothalamic leptin signaling and neural development in the selectively bred diet-induced obese rat. Am J Physiol Regul Integr Comp Physiol. 2016 Dec 01; 311(6):R1032-R1044..
        View in: PubMed
      2. Maillard J, Park S, Croizier S, Vanacker C, Cook JH, Prevot V, Tauber M, Bouret SG. Loss of Magel2 impairs the development of hypothalamic Anorexigenic circuits. Hum Mol Genet. 2016 Aug 01; 25(15):3208-3215..
        View in: PubMed
      3. Croizier S, Prevot V, Bouret SG. Leptin Controls Parasympathetic Wiring of the Pancreas during Embryonic Life. Cell Rep. 2016 Apr 5; 15(1):36-44..
        View in: PubMed
      4. Zigman JM, Bouret SG, Andrews ZB. Correction to 'Obesity Impairs the Action of the Neuroendocrine Ghrelin System': [Trends in Endocrinology and Metabolism, 27 (2016) 54-63]. Trends Endocrinol Metab. 2016 May; 27(5):348..
        View in: PubMed
      5. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016 Jan 2; 12(1):1-222..
        View in: PubMed
      6. Zigman JM, Bouret SG, Andrews ZB. Obesity Impairs the Action of the Neuroendocrine Ghrelin System. Trends Endocrinol Metab. 2016 Jan; 27(1):54-63..
        View in: PubMed
      7. Kayser BD, Goran MI, Bouret SG. Perinatal Overnutrition Exacerbates Adipose Tissue Inflammation Caused by High-Fat Feeding in C57BL/6J Mice. PLoS One. 2015; 10(3):e0121954..
        View in: PubMed
      8. Steculorum SM, Collden G, Coupe B, Croizier S, Lockie S, Andrews ZB, Jarosch F, Klussmann S, Bouret SG. Neonatal ghrelin programs development of hypothalamic feeding circuits. J Clin Invest. 2015 Feb 2; 125(2):846-58..
        View in: PubMed
      9. Bouret S, Levin BE, Ozanne SE. Gene-environment interactions controlling energy and glucose homeostasis and the developmental origins of obesity. Physiol Rev. 2015 Jan; 95(1):47-82..
        View in: PubMed
      10. Collden G, Balland E, Parkash J, Caron E, Langlet F, Prevot V, Bouret SG. Neonatal overnutrition causes early alterations in the central response to peripheral ghrelin. Mol Metab. 2015 Jan; 4(1):15-24..
        View in: PubMed
      11. Bellefontaine N, Chachlaki K, Parkash J, Vanacker C, Colledge W, d'Anglemont de Tassigny X, Garthwaite J, Bouret SG, Prevot V. Leptin-dependent neuronal NO signaling in the preoptic hypothalamus facilitates reproduction. J Clin Invest. 2014 Jun 2; 124(6):2550-9..
        View in: PubMed
      12. Balland E, Dam J, Langlet F, Caron E, Steculorum S, Messina A, Rasika S, Falluel-Morel A, Anouar Y, Dehouck B, Trinquet E, Jockers R, Bouret SG, Prévot V. Hypothalamic Tanycytes Are an ERK-Gated Conduit for Leptin into the Brain. Cell Metab. 2014 Feb 4; 19(2):293-301..
        View in: PubMed
      13. Langlet F, Mullier A, Bouret SG, Prevot V, Dehouck B. Tanycyte-like cells form a blood-cerebrospinal fluid barrier in the circumventricular organs of the mouse brain. J Comp Neurol. 2013 Oct 15; 521(15):3389-405..
        View in: PubMed
      14. Goran MI, Dumke K, Bouret SG, Kayser B, Walker RW, Blumberg B. The obesogenic effect of high fructose exposure during early development. Nat Rev Endocrinol. 2013 Aug; 9(8):494-500..
        View in: PubMed
      15. Langlet F, Levin BE, Luquet S, Mazzone M, Messina A, Dunn-Meynell AA, Balland E, Lacombe A, Mazur D, Carmeliet P, Bouret SG, Prevot V, Dehouck B. Tanycytic VEGF-A boosts blood-hypothalamus barrier plasticity and access of metabolic signals to the arcuate nucleus in response to fasting. Cell Metab. 2013 Apr 2; 17(4):607-17..
        View in: PubMed
      16. Coupe B, Bouret SG. Development of the hypothalamic melanocortin system. Front Endocrinol (Lausanne). 2013; 4:38..
        View in: PubMed
      17. Bouret SG. Organizational actions of metabolic hormones. Front Neuroendocrinol. 2013 Jan; 34(1):18-26..
        View in: PubMed
      18. Bouret SG. RIPping off GABA release in hypothalamic circuits causes obesity. Cell Metab. 2012 Nov 7; 16(5):557-8..
        View in: PubMed
      19. Caron E, Ciofi P, Prevot V, Bouret SG. Alteration in neonatal nutrition causes perturbations in hypothalamic neural circuits controlling reproductive function. J Neurosci. 2012 Aug 15; 32(33):11486-94..
        View in: PubMed
      20. Ishii Y, Bouret SG. Embryonic birthdate of hypothalamic leptin-activated neurons in mice. Endocrinology. 2012 Aug; 153(8):3657-67..
        View in: PubMed
      21. Coupé B, Bouret SG. Weighing on autophagy: A novel mechanism for the CNS regulation of energy balance. Cell Cycle. 2012 Apr 15; 11(8):1477-8..
        View in: PubMed
      22. Laloux C, Mairesse J, Van Camp G, Giovine A, Branchi I, Bouret S, Morley-Fletcher S, Bergonzelli G, Malagodi M, Gradini R, Nicoletti F, Darnaudéry M, Maccari S. Anxiety-like behaviour and associated neurochemical and endocrinological alterations in male pups exposed to prenatal stress. Psychoneuroendocrinology. 2012 Oct; 37(10):1646-58..
        View in: PubMed
      23. Coupé B, Ishii Y, Dietrich MO, Komatsu M, Horvath TL, Bouret SG. Loss of Autophagy in Pro-opiomelanocortin Neurons Perturbs Axon Growth and Causes Metabolic Dysregulation. Cell Metab. 2012 Feb 8; 15(2):247-55..
        View in: PubMed
      24. Bouret SG, Bates SH, Chen S, Myers MG, Simerly RB. Distinct roles for specific leptin receptor signals in the development of hypothalamic feeding circuits. J Neurosci. 2012 Jan 25; 32(4):1244-52..
        View in: PubMed
      25. Steculorum SM, Bouret SG. Maternal diabetes compromises the organization of hypothalamic feeding circuits and impairs leptin sensitivity in offspring. Endocrinology. 2011 Nov; 152(11):4171-9..
        View in: PubMed
      26. Steculorum SM, Bouret SG. Developmental effects of ghrelin. Peptides. 2011 Nov; 32(11):2362-6..
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      27. Pan W, Hsuchou H, Xu C, Wu X, Bouret SG, Kastin AJ. Astrocytes modulate distribution and neuronal signaling of leptin in the hypothalamus of obese A vy mice. J Mol Neurosci. 2011 Mar; 43(3):478-84..
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      28. Patterson CM, Bouret SG, Park S, Irani BG, Dunn-Meynell AA, Levin BE. Large litter rearing enhances leptin sensitivity and protects selectively bred diet-induced obese rats from becoming obese. Endocrinology. 2010 Sep; 151(9):4270-9..
        View in: PubMed
      29. Bouret SG. Neurodevelopmental actions of leptin. Brain Res. 2010 Sep 2; 1350:2-9..
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      30. Mullier A, Bouret SG, Prevot V, Dehouck B. Differential distribution of tight junction proteins suggests a role for tanycytes in blood-hypothalamus barrier regulation in the adult mouse brain. J Comp Neurol. 2010 Apr 1; 518(7):943-62..
        View in: PubMed
      31. Caron E, Sachot C, Prevot V, Bouret SG. Distribution of leptin-sensitive cells in the postnatal and adult mouse brain. J Comp Neurol. 2010 Feb 15; 518(4):459-76..
        View in: PubMed
      32. Bouret SG. Leptin, nutrition, and the programming of hypothalamic feeding circuits. Nestle Nutr Workshop Ser Pediatr Program. 2010; 65:25-35; discussion 35-9..
        View in: PubMed
      33. Bouret SG. Role of early hormonal and nutritional experiences in shaping feeding behavior and hypothalamic development. J Nutr. 2010 Mar; 140(3):653-7..
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      34. Bouret SG. Development of hypothalamic neural networks controlling appetite. Forum Nutr. 2010; 63:84-93..
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      35. Bouret SG. Early life origins of obesity: role of hypothalamic programming. J Pediatr Gastroenterol Nutr. 2009 Mar; 48 Suppl 1:S31-8..
        View in: PubMed
      36. Patterson CM, Bouret SG, Dunn-Meynell AA, Levin BE. Three weeks of postweaning exercise in DIO rats produces prolonged increases in central leptin sensitivity and signaling. Am J Physiol Regul Integr Comp Physiol. 2009 Mar; 296(3):R537-48..
        View in: PubMed
      37. Bouret SG. Crossing the border: developmental regulation of leptin transport to the brain. Endocrinology. 2008 Mar; 149(3):875-6..
        View in: PubMed
      38. Bouret SG, Gorski JN, Patterson CM, Chen S, Levin BE, Simerly RB. Hypothalamic neural projections are permanently disrupted in diet-induced obese rats. Cell Metab. 2008 Feb; 7(2):179-85..
        View in: PubMed
      39. Bouret SG, Simerly RB. Development of leptin-sensitive circuits. J Neuroendocrinol. 2007 Aug; 19(8):575-82..
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      40. Prevot V, Dehouck B, Poulain P, Beauvillain JC, Buée-Scherrer V, Bouret S. Neuronal-glial-endothelial interactions and cell plasticity in the postnatal hypothalamus: implications for the neuroendocrine control of reproduction. Psychoneuroendocrinology. 2007 Aug; 32 Suppl 1:S46-51..
        View in: PubMed
      41. Bouret SG, Simerly RB. Developmental programming of hypothalamic feeding circuits. Clin Genet. 2006 Oct; 70(4):295-301..
        View in: PubMed
      42. Gohlke BC, Huber A, Bartmann P, Fimmers R, Hecher K, Bouret SG, Roth CL. Cord blood leptin and IGF-I in relation to birth weight differences and head circumference in monozygotic twins. J Pediatr Endocrinol Metab. 2006 Jan; 19(1):3-9..
        View in: PubMed
      43. Bouret SG, Draper SJ, Simerly RB. Trophic action of leptin on hypothalamic neurons that regulate feeding. Science. 2004 Apr 2; 304(5667):108-10..
        View in: PubMed
      44. Bouret SG, Simerly RB. Minireview: Leptin and development of hypothalamic feeding circuits. Endocrinology. 2004 Jun; 145(6):2621-6..
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      45. Bouret SG, Draper SJ, Simerly RB. Formation of projection pathways from the arcuate nucleus of the hypothalamus to hypothalamic regions implicated in the neural control of feeding behavior in mice. J Neurosci. 2004 Mar 17; 24(11):2797-805..
        View in: PubMed
      46. Bouret S, De Seranno S, Beauvillain JC, Prevot V. Transforming growth factor beta1 may directly influence gonadotropin-releasing hormone gene expression in the rat hypothalamus. Endocrinology. 2004 Apr; 145(4):1794-801..
        View in: PubMed
      47. Bouret S, Tran Van Chuoi-Mariot M, Prevot V, Croix D, Takumi T, Jegou S, Vaudry H, Beauvillain JC, Mitchell V. Evidence that TGFß May Directly Modulate POMC mRNA Expression in the Female Rat Arcuate Nucleus. Endocrinology. 2001 Sep 01; 142(9):4055-4065..
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