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    Scott E Fraser, PhD

    TitleDirector of Science Initiatives, Provost Professor of Biological Sciences & Biomedical Engineering
    SchoolOffice of Provost
    DepartmentOffice of the Provost
    AddressRRI 401
    University Park Campus
    Los Angeles California 90089-2910
    Phone+1 213 740 2414
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      Fraser Lab Website

      Professor Scott E. Fraser has a long-standing commitment to quantitative biology, applying the tools of chemistry, engineering and physics to problems in biology and medicine. His personal research centers on imaging and molecular analyses of intact biological systems, with an emphasis on early development, organogenesis, and medical diagnostics. After training in physics (BS, Harvey Mudd College, 1976) and biophysics (PhD, Johns Hopkins University, 1979), he joined the faculty at UC Irvine, and rose through the ranks to become Chair of the Department of Physiology and Biophysics. In 1990 he moved to Caltech to serve as the Anna L. Rosen Professor of Biology, and the Director of the Biological Imaging Center. He is deeply committed to interdisciplinary training and translational research, having helped found the Caltech Brain Imaging Center and the Kavli Institute of Nanoscience, as well as serving as the Director of the Rosen Center for Biological Engineering. In Fall 2012, he moved to USC to take a Provost Professorship in the Dornsife College of Letters, Arts and Sciences, the Children’s Hospital Los Angeles, Keck School of Medicine and the Viterbi School of Engineering. He remains active in interdisciplinary research and serves as the Director of Science Initiatives for the USC campuses.


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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Bower DV, Lansdale N, Navarro S, Truong TV, Bower DJ, Featherstone NC, Connell MG, Al-Alam D, Frey MR, Trinh LA, Fernandez GE, Warburton D, Fraser S, Bennett D, Jesudason EC. SERCA directs cell migration and branching across species and germ layers. Biol Open. 2017 Aug 17. PMID: 28821490.
        View in: PubMed
      2. Browne AW, Arnesano C, Harutyunyan N, Khuu T, Martinez JC, Pollack HA, Koos DS, Lee TC, Fraser S, Moats RA, Aparicio JG, Cobrinik D. Structural and Functional Characterization of Human Stem-Cell-Derived Retinal Organoids by Live Imaging. Invest Ophthalmol Vis Sci. 2017 Jul 01; 58(9):3311-3318. PMID: 28672397.
        View in: PubMed
      3. Cutrale F, Trivedi V, Trinh LA, Chiu CL, Choi JM, Artiga MS, Fraser S. Hyperspectral phasor analysis enables multiplexed 5D in vivo imaging. Nat Methods. 2017 Feb; 14(2):149-152. PMID: 28068315.
        View in: PubMed
      4. Chen Y, Trinh LA, Fingler J, Fraser S. Phase variance optical coherence microscopy for label-free imaging of the developing vasculature in zebrafish embryos. J Biomed Opt. 2016 12 01; 21(12):126022. PMID: 28036094.
        View in: PubMed
      5. Cronan MR, Beerman RW, Rosenberg AF, Saelens JW, Johnson MG, Oehlers SH, Sisk DM, Jurcic Smith KL, Medvitz NA, Miller SE, Trinh LA, Fraser S, Madden JF, Turner J, Stout JE, Lee S, Tobin DM. Macrophage Epithelial Reprogramming Underlies Mycobacterial Granuloma Formation and Promotes Infection. Immunity. 2016 Oct 18; 45(4):861-876. PMID: 27760340.
        View in: PubMed
      6. Choi HM, Calvert CR, Husain N, Huss D, Barsi JC, Deverman BE, Hunter RC, Kato M, Lee SM, Abelin AC, Rosenthal AZ, Akbari OS, Li Y, Hay BA, Sternberg PW, Patterson PH, Davidson EH, Mazmanian SK, Prober DA, van de Rijn M, Leadbetter JR, Newman DK, Readhead C, Bronner ME, Wold B, Lansford R, Sauka-Spengler T, Fraser S, Pierce NA. Mapping a multiplexed zoo of mRNA expression. Development. 2016 Oct 01; 143(19):3632-3637. PMID: 27702788.
        View in: PubMed
      7. Gross GG, Straub C, Perez-Sanchez J, Dempsey WP, Junge JA, Roberts RW, Trinh le A, Fraser S, De Koninck Y, De Koninck P, Sabatini BL, Arnold DB. An E3-ligase-based method for ablating inhibitory synapses. Nat Methods. 2016 Aug; 13(8):673-8. PMID: 27271196.
        View in: PubMed
      8. Chiu CL, Patsch K, Cutrale F, Soundararajan A, Agus DB, Fraser S, Ruderman D. Intracellular kinetics of the androgen receptor shown by multimodal Image Correlation Spectroscopy (mICS). Sci Rep. 2016 Mar 03; 6:22435. PMID: 26936218; PMCID: PMC4776155.
      9. Kitano M, Yamazaki C, Takumi A, Ikeno T, Hemmi H, Takahashi N, Shimizu K, Fraser S, Hoshino K, Kaisho T, Okada T. Imaging of the cross-presenting dendritic cell subsets in the skin-draining lymph node. Proc Natl Acad Sci U S A. 2016 Jan 26; 113(4):1044-9. PMID: 26755602; PMCID: PMC4743831.
      10. Ndjamen B, Joshi DS, Fraser S, Bjorkman PJ. Characterization of Antibody Bipolar Bridging Mediated by the Human Cytomegalovirus Fc Receptor gp68. J Virol. 2016 Jan 06; 90(6):3262-7. PMID: 26739053; PMCID: PMC4810659.
      11. Biteen JS, Blainey PC, Cardon ZG, Chun M, Church GM, Dorrestein PC, Fraser S, Gilbert JA, Jansson JK, Knight R, Miller JF, Ozcan A, Prather KA, Quake SR, Ruby EG, Silver PA, Taha S, van den Engh G, Weiss PS, Wong GC, Wright AT, Young TD. Tools for the Microbiome: Nano and Beyond. ACS Nano. 2016 Jan 26; 10(1):6-37. PMID: 26695070.
        View in: PubMed
      12. Trinh le A, Fraser S. Imaging the Cell and Molecular Dynamics of Craniofacial Development: Challenges and New Opportunities in Imaging Developmental Tissue Patterning. Curr Top Dev Biol. 2015; 115:599-629. PMID: 26589939.
        View in: PubMed
      13. Shin YJ, Park SK, Jung YJ, Kim YN, Kim KS, Park OK, Kwon SH, Jeon SH, Trinh le A, Fraser S, Kee Y, Hwang BJ. Nanobody-targeted E3-ubiquitin ligase complex degrades nuclear proteins. Sci Rep. 2015 Sep 16; 5:14269. PMID: 26373678; PMCID: PMC4571616.
      14. Huss D, Benazeraf B, Wallingford A, Filla M, Yang J, Fraser S, Lansford R. A transgenic quail model that enables dynamic imaging of amniote embryogenesis. Development. 2015 Aug 15; 142(16):2850-9. PMID: 26209648; PMCID: PMC4550965.
      15. McClintic SM, Kim DY, Fingler J, Garcia S, Zawadzki RJ, Morse LS, Park SS, Fraser S, Werner JS, Ruggiero JP, Schwartz DM. Detection of pigment epithelial detachment vascularization in age-related macular degeneration using phase-variance OCT angiography. Clin Ophthalmol. 2015; 9:1299-305. PMID: 26203220; PMCID: PMC4508080.
      16. Ruf-Zamojski F, Trivedi V, Fraser S, Trinh le A. Spatio-Temporal Differences in Dystrophin Dynamics at mRNA and Protein Levels Revealed by a Novel FlipTrap Line. PLoS One. 2015; 10(6):e0128944. PMID: 26083378; PMCID: PMC4471274.
      17. Trivedi V, Truong TV, Trinh le A, Holland DB, Liebling M, Fraser S. Dynamic structure and protein expression of the live embryonic heart captured by 2-photon light sheet microscopy and retrospective registration. Biomed Opt Express. 2015 Jun 01; 6(6):2056-66. PMID: 26114028; PMCID: PMC4473743.
      18. Li Y, Trivedi V, Truong TV, Koos DS, Lansford R, Chuong CM, Warburton D, Moats RA, Fraser S. Dynamic imaging of the growth plate cartilage reveals multiple contributors to skeletal morphogenesis. Nat Commun. 2015 Apr 13; 6:6798. PMID: 25865282; PMCID: PMC4403347.
      19. Huss D, Choi HM, Readhead C, Fraser S, Pierce NA, Lansford R. Combinatorial analysis of mRNA expression patterns in mouse embryos using hybridization chain reaction. Cold Spring Harb Protoc. 2015 Mar 02; 2015(3):259-68. PMID: 25734068.
        View in: PubMed
      20. Bower DV, Lee HK, Lansford R, Zinn K, Warburton D, Fraser S, Jesudason EC. Airway branching has conserved needs for local parasympathetic innervation but not neurotransmission. BMC Biol. 2014 Nov 11; 12:92. PMID: 25385196; PMCID: PMC4255442.
      21. Serrano-Velez JL, Rodriguez-Alvarado M, Torres-Vazquez II, Fraser S, Yasumura T, Vanderpool KG, Rash JE, Rosa-Molinar E. Abundance of gap junctions at glutamatergic mixed synapses in adult Mosquitofish spinal cord neurons. Front Neural Circuits. 2014; 8:66. PMID: 25018700; PMCID: PMC4072101.
      22. Ndjamen B, Farley AH, Lee T, Fraser S, Bjorkman PJ. The herpes virus Fc receptor gE-gI mediates antibody bipolar bridging to clear viral antigens from the cell surface. PLoS Pathog. 2014 Mar; 10(3):e1003961. PMID: 24604090; PMCID: PMC3946383.
      23. Chandrashekran A, Sarkar R, Thrasher A, Fraser S, Dibb N, Casimir C, Winston R, Readhead C. Efficient generation of transgenic mice by lentivirus-mediated modification of spermatozoa. FASEB J. 2014 Feb; 28(2):569-76. PMID: 24297703.
        View in: PubMed
      24. Schwartz DM, Fingler J, Kim DY, Zawadzki RJ, Morse LS, Park SS, Fraser S, Werner JS. Phase-variance optical coherence tomography: a technique for noninvasive angiography. Ophthalmology. 2014 Jan; 121(1):180-7. PMID: 24156929; PMCID: PMC4190463.
      25. Kim DY, Fingler J, Zawadzki RJ, Park SS, Morse LS, Schwartz DM, Fraser S, Werner JS. Optical imaging of the chorioretinal vasculature in the living human eye. Proc Natl Acad Sci U S A. 2013 Aug 27; 110(35):14354-9. PMID: 23918361; PMCID: PMC3761584.
      26. Trinh le A, Fraser S. Enhancer and gene traps for molecular imaging and genetic analysis in zebrafish. Dev Growth Differ. 2013 May; 55(4):434-45. PMID: 23565993.
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      27. Alivisatos AP, Andrews AM, Boyden ES, Chun M, Church GM, Deisseroth K, Donoghue JP, Fraser S, Lippincott-Schwartz J, Looger LL, Masmanidis S, McEuen PL, Nurmikko AV, Park H, Peterka DS, Reid C, Roukes ML, Scherer A, Schnitzer M, Sejnowski TJ, Shepard KL, Tsao D, Turrigiano G, Weiss PS, Xu C, Yuste R, Zhuang X. Nanotools for neuroscience and brain activity mapping. ACS Nano. 2013 Mar 26; 7(3):1850-66. PMID: 23514423; PMCID: PMC3665747.
      28. Seidl AH, Sanchez JT, Schecterson L, Tabor KM, Wang Y, Kashima DT, Poynter G, Huss D, Fraser S, Lansford R, Rubel EW. Transgenic quail as a model for research in the avian nervous system: a comparative study of the auditory brainstem. J Comp Neurol. 2013 Jan 01; 521(1):5-23. PMID: 22806400; PMCID: PMC3488602.
      29. Palanca AM, Lee SL, Yee LE, Joe-Wong C, Trinh le A, Hiroyasu E, Husain M, Fraser S, Pellegrini M, Sagasti A. New transgenic reporters identify somatosensory neuron subtypes in larval zebrafish. Dev Neurobiol. 2013 Feb; 73(2):152-67. PMID: 22865660; PMCID: PMC3541445.
      30. Culic-Viskota J, Dempsey WP, Fraser S, Pantazis P. Surface functionalization of barium titanate SHG nanoprobes for in vivo imaging in zebrafish. Nat Protoc. 2012 Sep; 7(9):1618-33. PMID: 22899331.
        View in: PubMed
      31. Liu CY, Xiao C, Fraser S, Lester HA, Koos DS. Electrophysiological characterization of Grueneberg ganglion olfactory neurons: spontaneous firing, sodium conductance, and hyperpolarization-activated currents. J Neurophysiol. 2012 Sep; 108(5):1318-34. PMID: 22649209; PMCID: PMC3544954.
      32. Motaghiannezam R, Schwartz DM, Fraser S. In vivo human choroidal vascular pattern visualization using high-speed swept-source optical coherence tomography at 1060 nm. Invest Ophthalmol Vis Sci. 2012 Apr 30; 53(4):2337-48. PMID: 22410568.
        View in: PubMed
      33. Dempsey WP, Fraser S, Pantazis P. PhOTO zebrafish: a transgenic resource for in vivo lineage tracing during development and regeneration. PLoS One. 2012; 7(3):e32888. PMID: 22431986; PMCID: PMC3303793.
      34. Dempsey WP, Fraser S, Pantazis P. SHG nanoprobes: advancing harmonic imaging in biology. Bioessays. 2012 May; 34(5):351-60. PMID: 22392481.
        View in: PubMed
      35. Motaghiannezam R, Fraser S. Logarithmic intensity and speckle-based motion contrast methods for human retinal vasculature visualization using swept source optical coherence tomography. Biomed Opt Express. 2012 Mar 01; 3(3):503-21. PMID: 22435098; PMCID: PMC3296538.
      36. Motaghiannezam SM, Koos D, Fraser S. Differential phase-contrast, swept-source optical coherence tomography at 1060 nm for in vivo human retinal and choroidal vasculature visualization. J Biomed Opt. 2012 Feb; 17(2):026011. PMID: 22463043.
        View in: PubMed
      37. Kim DY, Fingler J, Zawadzki RJ, Park SS, Morse LS, Schwartz DM, Fraser S, Werner JS. Noninvasive imaging of the foveal avascular zone with high-speed, phase-variance optical coherence tomography. Invest Ophthalmol Vis Sci. 2012 Jan 05; 53(1):85-92. PMID: 22125275; PMCID: PMC3292386.
      38. Trinh le A, Hochgreb T, Graham M, Wu D, Ruf-Zamojski F, Jayasena CS, Saxena A, Hawk R, Gonzalez-Serricchio A, Dixson A, Chow E, Gonzales C, Leung HY, Solomon I, Bronner-Fraser M, Megason SG, Fraser S. A versatile gene trap to visualize and interrogate the function of the vertebrate proteome. Genes Dev. 2011 Nov 01; 25(21):2306-20. PMID: 22056673; PMCID: PMC3219234.
      39. Cooley J, Whitaker S, Sweeney S, Fraser S, Davidson B. Cytoskeletal polarity mediates localized induction of the heart progenitor lineage. Nat Cell Biol. 2011 Jul 24; 13(8):952-7. PMID: 21785423; PMCID: PMC3149722.
      40. Truong TV, Supatto W, Koos DS, Choi JM, Fraser S. Deep and fast live imaging with two-photon scanned light-sheet microscopy. Nat Methods. 2011 Jul 17; 8(9):757-60. PMID: 21765409.
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      41. Wu Z, Todorov I, Li L, Bading JR, Li Z, Nair I, Ishiyama K, Colcher D, Conti PE, Fraser S, Shively JE, Kandeel F. In vivo imaging of transplanted islets with 64Cu-DO3A-VS-Cys40-Exendin-4 by targeting GLP-1 receptor. Bioconjug Chem. 2011 Aug 17; 22(8):1587-94. PMID: 21692471.
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      42. Amit R, Garcia HG, Phillips R, Fraser S. Building enhancers from the ground up: a synthetic biology approach. Cell. 2011 Jul 08; 146(1):105-18. PMID: 21729783; PMCID: PMC3155781.
      43. Ohn J, Yang J, Fraser S, Lansford R, Liebling M. High-speed multicolor microscopy of repeating dynamic processes. Genesis. 2011 Jul; 49(7):514-21. PMID: 21638751; PMCID: PMC3344748.
      44. Caneparo L, Pantazis P, Dempsey W, Fraser S. Intercellular bridges in vertebrate gastrulation. PLoS One. 2011; 6(5):e20230. PMID: 21647454; PMCID: PMC3102083.
      45. Kim DY, Fingler J, Werner JS, Schwartz DM, Fraser S, Zawadzki RJ. In vivo volumetric imaging of human retinal circulation with phase-variance optical coherence tomography. Biomed Opt Express. 2011 Jun 01; 2(6):1504-13. PMID: 21698014; PMCID: PMC3114219.
      46. Hochheiser H, Aronow BJ, Artinger K, Beaty TH, Brinkley JF, Chai Y, Clouthier D, Cunningham ML, Dixon M, Donahue LR, Fraser S, Hallgrimsson B, Iwata J, Klein O, Marazita ML, Murray JC, Murray S, de Villena FP, Postlethwait J, Potter S, Shapiro L, Spritz R, Visel A, Weinberg SM, Trainor PA. The FaceBase Consortium: a comprehensive program to facilitate craniofacial research. Dev Biol. 2011 Jul 15; 355(2):175-82. PMID: 21458441; PMCID: PMC3440302.
      47. Lu T, Lee H, Chen T, Herchak S, Kim JH, Fraser S, Flagan RC, Vahala K. High sensitivity nanoparticle detection using optical microcavities. Proc Natl Acad Sci U S A. 2011 Apr 12; 108(15):5976-9. PMID: 21444782; PMCID: PMC3076881.
      48. Wu D, Freund JB, Fraser S, Vermot J. Mechanistic basis of otolith formation during teleost inner ear development. Dev Cell. 2011 Feb 15; 20(2):271-8. PMID: 21316594; PMCID: PMC4556435.
      49. Plachta N, Bollenbach T, Pease S, Fraser S, Pantazis P. Oct4 kinetics predict cell lineage patterning in the early mammalian embryo. Nat Cell Biol. 2011 Feb; 13(2):117-23. PMID: 21258368.
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      50. Alesutan I, Föller M, Sopjani M, Dërmaku-Sopjani M, Zelenak C, Fröhlich H, Velic A, Fraser S, Kemp BE, Seebohm G, Völkl H, Lang F. Inhibition of the heterotetrameric K+ channel KCNQ1/KCNE1 by the AMP-activated protein kinase. Mol Membr Biol. 2011 Feb; 28(2):79-89. PMID: 21231794.
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      51. Žigman M, Trinh le A, Fraser S, Moens CB. Zebrafish neural tube morphogenesis requires Scribble-dependent oriented cell divisions. Curr Biol. 2011 Jan 11; 21(1):79-86. PMID: 21185191; PMCID: PMC4308621.
      52. Varma D, Adams W, Bunce C, Phelan P, Fraser S. Viscogonioplasty in narrow angle glaucoma: a randomized controlled trial. Clin Ophthalmol. 2010 Dec 08; 4:1475-9. PMID: 21191443; PMCID: PMC3009994.
      53. Ezin AM, Sechrist JW, Zah A, Bronner M, Fraser S. Early regulative ability of the neuroepithelium to form cardiac neural crest. Dev Biol. 2011 Jan 15; 349(2):238-49. PMID: 21047505; PMCID: PMC3018664.
      54. Choi HM, Chang JY, Trinh le A, Padilla JE, Fraser S, Pierce NA. Programmable in situ amplification for multiplexed imaging of mRNA expression. Nat Biotechnol. 2010 Nov; 28(11):1208-12. PMID: 21037591; PMCID: PMC3058322.
      55. Quesada-Hernández E, Caneparo L, Schneider S, Winkler S, Liebling M, Fraser S, Heisenberg CP. Stereotypical cell division orientation controls neural rod midline formation in zebrafish. Curr Biol. 2010 Nov 09; 20(21):1966-72. PMID: 20970340.
        View in: PubMed
      56. Sato Y, Poynter G, Huss D, Filla MB, Czirok A, Rongish BJ, Little CD, Fraser S, Lansford R. Dynamic analysis of vascular morphogenesis using transgenic quail embryos. PLoS One. 2010 Sep 14; 5(9):e12674. PMID: 20856866; PMCID: PMC2939056.
      57. Pantazis P, Maloney J, Wu D, Fraser S. Second harmonic generating (SHG) nanoprobes for in vivo imaging. Proc Natl Acad Sci U S A. 2010 Aug 17; 107(33):14535-40. PMID: 20668245; PMCID: PMC2930484.
      58. Pikov V, Arakaki X, Harrington M, Fraser S, Siegel PH. Modulation of neuronal activity and plasma membrane properties with low-power millimeter waves in organotypic cortical slices. J Neural Eng. 2010 Aug; 7(4):045003. PMID: 20644247.
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      59. Kulesa PM, Bailey CM, Cooper C, Fraser S. In ovo live imaging of avian embryos. Cold Spring Harb Protoc. 2010 Jun; 2010(6):pdb.prot5446. PMID: 20516184; PMCID: PMC3491899.
      60. Jerdeva GV, Tesar DB, Huey-Tubman KE, Ladinsky MS, Fraser S, Bjorkman PJ. Comparison of FcRn- and pIgR-mediated transport in MDCK cells by fluorescence confocal microscopy. Traffic. 2010 Sep; 11(9):1205-20. PMID: 20525015; PMCID: PMC2975666.
      61. Fraser S. Corneal abrasion. Clin Ophthalmol. 2010 May 06; 4:387-90. PMID: 20463909; PMCID: PMC2866569.
      62. Sopjani M, Alesutan I, Dërmaku-Sopjani M, Fraser S, Kemp BE, Föller M, Lang F. Down-regulation of Na+-coupled glutamate transporter EAAT3 and EAAT4 by AMP-activated protein kinase. J Neurochem. 2010 Jun; 113(6):1426-35. PMID: 20218975.
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      63. Fingler J, Zawadzki RJ, Werner JS, Schwartz D, Fraser S. Volumetric microvascular imaging of human retina using optical coherence tomography with a novel motion contrast technique. Opt Express. 2009 Nov 23; 17(24):22190-200. PMID: 19997465; PMCID: PMC2791341.
      64. Vermot J, Forouhar AS, Liebling M, Wu D, Plummer D, Gharib M, Fraser S. Reversing blood flows act through klf2a to ensure normal valvulogenesis in the developing heart. PLoS Biol. 2009 Nov; 7(11):e1000246. PMID: 19924233; PMCID: PMC2773122.
      65. Supatto W, McMahon A, Fraser S, Stathopoulos A. Quantitative imaging of collective cell migration during Drosophila gastrulation: multiphoton microscopy and computational analysis. Nat Protoc. 2009; 4(10):1397-412. PMID: 19745822; PMCID: PMC2854020.
      66. Liu CY, Fraser S, Koos DS. Grueneberg ganglion olfactory subsystem employs a cGMP signaling pathway. J Comp Neurol. 2009 Sep 01; 516(1):36-48. PMID: 19565523; PMCID: PMC4314211.
      67. Wu D, Ghosh K, Inamdar M, Lee HJ, Fraser S, Dill K, Phillips R. Trajectory approach to two-state kinetics of single particles on sculpted energy landscapes. Phys Rev Lett. 2009 Jul 31; 103(5):050603. PMID: 19792475; PMCID: PMC3273425.
      68. Wride N, Habib M, Morris K, Campbell S, Fraser S. Clinical evaluation of a rapid, pupil-based assessment of retinal damage associated with glaucoma. Clin Ophthalmol. 2009; 3:123-8. PMID: 19668555; PMCID: PMC2709032.
      69. Demyanenko AV, Zhao L, Kee Y, Nie S, Fraser S, Tyszka JM. A uniplanar three-axis gradient set for in vivo magnetic resonance microscopy. J Magn Reson. 2009 Sep; 200(1):38-48. PMID: 19539503.
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      70. Ezin AM, Fraser S, Bronner-Fraser M. Fate map and morphogenesis of presumptive neural crest and dorsal neural tube. Dev Biol. 2009 Jun 15; 330(2):221-36. PMID: 19332051; PMCID: PMC2717095.
      71. Reeves GT, Fraser S. Biological systems from an engineer's point of view. PLoS Biol. 2009 Jan 20; 7(1):e21. PMID: 19166272; PMCID: PMC2628404.
      72. Kulkarni RP, Fraser S, Armani AM. Characterization of high-Q optical microcavities using confocal microscopy. Opt Lett. 2008 Dec 15; 33(24):2931-3. PMID: 19079496.
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      73. McMahon A, Supatto W, Fraser S, Stathopoulos A. Dynamic analyses of Drosophila gastrulation provide insights into collective cell migration. Science. 2008 Dec 05; 322(5907):1546-50. PMID: 19056986; PMCID: PMC2801059.
      74. Colantonio JR, Vermot J, Wu D, Langenbacher AD, Fraser S, Chen JN, Hill KL. The dynein regulatory complex is required for ciliary motility and otolith biogenesis in the inner ear. Nature. 2009 Jan 08; 457(7226):205-9. PMID: 19043402; PMCID: PMC3821763.
      75. Park S, Jamshidi Y, Vaideanu D, Bitner-Glindzicz M, Fraser S, Sowden JC. Genetic risk for primary open-angle glaucoma determined by LMX1B haplotypes. Invest Ophthalmol Vis Sci. 2009 Apr; 50(4):1522-30. PMID: 18952915.
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      76. Lin AP, Bennett E, Wisk LE, Gharib M, Fraser S, Wen H. Circumferential strain in the wall of the common carotid artery: comparing displacement-encoded and cine MRI in volunteers. Magn Reson Med. 2008 Jul; 60(1):8-13. PMID: 18581403; PMCID: PMC2886512.
      77. Fingler J, Readhead C, Schwartz DM, Fraser S. Phase-contrast OCT imaging of transverse flows in the mouse retina and choroid. Invest Ophthalmol Vis Sci. 2008 Nov; 49(11):5055-9. PMID: 18566457.
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      78. Supatto W, Fraser S, Vermot J. An all-optical approach for probing microscopic flows in living embryos. Biophys J. 2008 Aug; 95(4):L29-31. PMID: 18556762; PMCID: PMC2483781.
      79. Vermot J, Fraser S, Liebling M. Fast fluorescence microscopy for imaging the dynamics of embryonic development. HFSP J. 2008 Jun; 2(3):143-55. PMID: 19404468; PMCID: PMC2645566.
      80. Lu J, Pereira F, Fraser S, Gharib M. Three-dimensional real-time imaging of cardiac cell motions in living embryos. J Biomed Opt. 2008 Jan-Feb; 13(1):014006. PMID: 18315364.
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      81. Bhattacharyya S, Kulesa PM, Fraser S. Vital labeling of embryonic cells using fluorescent dyes and proteins. Methods Cell Biol. 2008; 87:187-210. PMID: 18485298.
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      82. Ezin M, Fraser S. Time-lapse imaging of the early avian embryo. Methods Cell Biol. 2008; 87:211-36. PMID: 18485299.
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      83. Fingler J, Schwartz D, Yang C, Fraser S. Mobility and transverse flow visualization using phase variance contrast with spectral domain optical coherence tomography. Opt Express. 2007 Oct 01; 15(20):12636-53. PMID: 19550532.
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      84. Megason SG, Fraser S. Imaging in systems biology. Cell. 2007 Sep 07; 130(5):784-95. PMID: 17803903.
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      85. Lucitti JL, Jones EA, Huang C, Chen J, Fraser S, Dickinson ME. Vascular remodeling of the mouse yolk sac requires hemodynamic force. Development. 2007 Sep; 134(18):3317-26. PMID: 17720695; PMCID: PMC4260474.
      86. Armani AM, Kulkarni RP, Fraser S, Flagan RC, Vahala KJ. Label-free, single-molecule detection with optical microcavities. Science. 2007 Aug 10; 317(5839):783-7. PMID: 17615303.
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      87. Fraser S. Scott Fraser: live action embryology. Interview by R Williams. J Cell Biol. 2007 Jun 04; 177(5):748-50. PMID: 17548508; PMCID: PMC2064275.
      88. Trinh le A, McCutchen MD, Bonner-Fraser M, Fraser S, Bumm LA, McCauley DW. Fluorescent in situ hybridization employing the conventional NBT/BCIP chromogenic stain. Biotechniques. 2007 Jun; 42(6):756-9. PMID: 17612300.
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      89. Ruffins SW, Martin M, Keough L, Truong S, Fraser S, Jacobs RE, Lansford R. Digital three-dimensional atlas of quail development using high-resolution MRI. ScientificWorldJournal. 2007 May 11; 7:592-604. PMID: 17525824.
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      90. Papan C, Boulat B, Velan SS, Fraser S, Jacobs RE. Formation of the dorsal marginal zone in Xenopus laevis analyzed by time-lapse microscopic magnetic resonance imaging. Dev Biol. 2007 May 01; 305(1):161-71. PMID: 17368611.
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      91. Papan C, Boulat B, Velan SS, Fraser S, Jacobs RE. Two-dimensional and three-dimensional time-lapse microscopic magnetic resonance imaging of Xenopus gastrulation movements using intrinsic tissue-specific contrast. Dev Dyn. 2007 Feb; 236(2):494-501. PMID: 17191224.
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      92. Kulkarni RP, Bak-Maier M, Fraser S. Differences in protein mobility between pioneer versus follower growth cones. Proc Natl Acad Sci U S A. 2007 Jan 23; 104(4):1207-12. PMID: 17229842; PMCID: PMC1783102.
      93. Martin M, Hiltner TD, Wood JC, Fraser S, Jacobs RE, Readhead C. Myelin deficiencies visualized in vivo: visually evoked potentials and T2-weighted magnetic resonance images of shiverer mutant and wild-type mice. J Neurosci Res. 2006 Dec; 84(8):1716-26. PMID: 17044038.
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      94. Papan C, Boulat B, Velan SS, Fraser S, Jacobs RE. Time-lapse tracing of mitotic cell divisions in the early Xenopus embryo using microscopic MRI. Dev Dyn. 2006 Nov; 235(11):3059-62. PMID: 16958098.
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      95. Liebling M, Forouhar AS, Wolleschensky R, Zimmermann B, Ankerhold R, Fraser S, Gharib M, Dickinson ME. Rapid three-dimensional imaging and analysis of the beating embryonic heart reveals functional changes during development. Dev Dyn. 2006 Nov; 235(11):2940-8. PMID: 16921497.
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      96. Martin M, Reyes SD, Hiltner TD, Givogri MI, Tyszka JM, Fisher R, Campagnoni AT, Fraser S, Jacobs RE, Readhead C. T(2)-weighted microMRI and evoked potential of the visual system measurements during the development of hypomyelinated transgenic mice. Neurochem Res. 2007 Feb; 32(2):159-65. PMID: 16927171.
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      97. Köster RW, Fraser S. FGF signaling mediates regeneration of the differentiating cerebellum through repatterning of the anterior hindbrain and reinitiation of neuronal migration. J Neurosci. 2006 Jul 05; 26(27):7293-304. PMID: 16822987.
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      98. Damle S, Hanser B, Davidson EH, Fraser S. Confocal quantification of cis-regulatory reporter gene expression in living sea urchin. Dev Biol. 2006 Nov 15; 299(2):543-50. PMID: 16919620.
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      99. Dickinson M, Jones E, Crotty D, Fraser S, Nagy A, Gertsenstein M, Vintersten K, Behringer R. Static culture of postimplantation embryos for imaging. CSH Protoc. 2006 Jun 01; 2006(1). PMID: 22485790.
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      100. Forouhar AS, Liebling M, Hickerson A, Nasiraei-Moghaddam A, Tsai HJ, Hove JR, Fraser S, Dickinson ME, Gharib M. The embryonic vertebrate heart tube is a dynamic suction pump. Science. 2006 May 05; 312(5774):751-3. PMID: 16675702.
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      101. Wang J, Hamblet NS, Mark S, Dickinson ME, Brinkman BC, Segil N, Fraser S, Chen P, Wallingford JB, Wynshaw-Boris A. Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation. Development. 2006 May; 133(9):1767-78. PMID: 16571627; PMCID: PMC4158842.
      102. Idrees F, Bloch-Zupan A, Free SL, Vaideanu D, Thompson PJ, Ashley P, Brice G, Rutland P, Bitner-Glindzicz M, Khaw PT, Fraser S, Sisodiya SM, Sowden JC. A novel homeobox mutation in the PITX2 gene in a family with Axenfeld-Rieger syndrome associated with brain, ocular, and dental phenotypes. Am J Med Genet B Neuropsychiatr Genet. 2006 Mar 05; 141B(2):184-91. PMID: 16389592.
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      103. Kulkarni RP, Castelino K, Majumdar A, Fraser S. Intracellular transport dynamics of endosomes containing DNA polyplexes along the microtubule network. Biophys J. 2006 Mar 01; 90(5):L42-4. PMID: 16399838; PMCID: PMC1367335.
      104. Canaria CA, So J, Maloney JR, Yu CJ, Smith JO, Roukes ML, Fraser S, Lansford R. Formation and removal of alkylthiolate self-assembled monolayers on gold in aqueous solutions. Lab Chip. 2006 Feb; 6(2):289-95. PMID: 16450040.
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      105. Tyszka JM, Ewald AJ, Wallingford JB, Fraser S. New tools for visualization and analysis of morphogenesis in spherical embryos. Dev Dyn. 2005 Dec; 234(4):974-83. PMID: 16193511.
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      106. Koos DS, Fraser S. The Grueneberg ganglion projects to the olfactory bulb. Neuroreport. 2005 Nov 28; 16(17):1929-32. PMID: 16272881.
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      107. Rieger S, Kulkarni RP, Darcy D, Fraser S, Köster RW. Quantum dots are powerful multipurpose vital labeling agents in zebrafish embryos. Dev Dyn. 2005 Nov; 234(3):670-81. PMID: 16110511.
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      108. Kulesa PM, Lu CC, Fraser S. Time-lapse analysis reveals a series of events by which cranial neural crest cells reroute around physical barriers. Brain Behav Evol. 2005; 66(4):255-65. PMID: 16254414.
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      109. Liebling M, Forouhar AS, Gharib M, Fraser S, Dickinson ME. Four-dimensional cardiac imaging in living embryos via postacquisition synchronization of nongated slice sequences. J Biomed Opt. 2005 Sep-Oct; 10(5):054001. PMID: 16292961.
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      110. Kulkarni RP, Mishra S, Fraser S, Davis ME. Single cell kinetics of intracellular, nonviral, nucleic acid delivery vehicle acidification and trafficking. Bioconjug Chem. 2005 Jul-Aug; 16(4):986-94. PMID: 16029041.
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      111. Kulkarni RP, Wu DD, Davis ME, Fraser S. Quantitating intracellular transport of polyplexes by spatio-temporal image correlation spectroscopy. Proc Natl Acad Sci U S A. 2005 May 24; 102(21):7523-8. PMID: 15897455; PMCID: PMC1140437.
      112. Tyszka JM, Fraser S, Jacobs RE. Magnetic resonance microscopy: recent advances and applications. Curr Opin Biotechnol. 2005 Feb; 16(1):93-9. PMID: 15722021.
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      113. Jones EA, Baron MH, Fraser S, Dickinson ME. Dynamic in vivo imaging of mammalian hematovascular development using whole embryo culture. Methods Mol Med. 2005; 105:381-94. PMID: 15492409.
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      114. Ewald AJ, Peyrot SM, Tyszka JM, Fraser S, Wallingford JB. Regional requirements for Dishevelled signaling during Xenopus gastrulation: separable effects on blastopore closure, mesendoderm internalization and archenteron formation. Development. 2004 Dec; 131(24):6195-209. PMID: 15548584.
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      115. Fraser S, Mount P, Hill R, Levidiotis V, Katsis F, Stapleton D, Kemp BE, Power DA. Regulation of the energy sensor AMP-activated protein kinase in the kidney by dietary salt intake and osmolality. Am J Physiol Renal Physiol. 2005 Mar; 288(3):F578-86. PMID: 15536169.
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      116. Gong Y, Mo C, Fraser S. Planar cell polarity signalling controls cell division orientation during zebrafish gastrulation. Nature. 2004 Aug 05; 430(7000):689-93. PMID: 15254551.
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      117. Dorman JB, James KE, Fraser S, Kiehart DP, Berg CA. bullwinkle is required for epithelial morphogenesis during Drosophila oogenesis. Dev Biol. 2004 Mar 15; 267(2):320-41. PMID: 15013797.
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      118. Köster RW, Fraser S. Time-lapse microscopy of brain development. Methods Cell Biol. 2004; 76:207-35. PMID: 15602878.
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      119. Modo M, Mellodew K, Cash D, Fraser S, Meade TJ, Price J, Williams SC. Mapping transplanted stem cell migration after a stroke: a serial, in vivo magnetic resonance imaging study. Neuroimage. 2004 Jan; 21(1):311-7. PMID: 14741669.
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      120. Nashmi R, Dickinson ME, McKinney S, Jareb M, Labarca C, Fraser S, Lester HA. Assembly of alpha4beta2 nicotinic acetylcholine receptors assessed with functional fluorescently labeled subunits: effects of localization, trafficking, and nicotine-induced upregulation in clonal mammalian cells and in cultured midbrain neurons. J Neurosci. 2003 Dec 17; 23(37):11554-67. PMID: 14684858.
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      121. Fraser S. Crystal gazing in optical microscopy. Nat Biotechnol. 2003 Nov; 21(11):1272-3. PMID: 14595350.
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      122. Megason SG, Fraser S. Digitizing life at the level of the cell: high-performance laser-scanning microscopy and image analysis for in toto imaging of development. Mech Dev. 2003 Nov; 120(11):1407-20. PMID: 14623446.
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      123. Bak M, Fraser S. Axon fasciculation and differences in midline kinetics between pioneer and follower axons within commissural fascicles. Development. 2003 Oct; 130(20):4999-5008. PMID: 12952902.
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      124. Jacobs RE, Papan C, Ruffins S, Tyszka JM, Fraser S. MRI: volumetric imaging for vital imaging and atlas construction. Nat Rev Mol Cell Biol. 2003 Sep; Suppl:SS10-6. PMID: 14587521.
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      125. Patten I, Kulesa P, Shen MM, Fraser S, Placzek M. Distinct modes of floor plate induction in the chick embryo. Development. 2003 Oct; 130(20):4809-21. PMID: 12917296.
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      126. Hadjantonakis AK, Dickinson ME, Fraser S, Papaioannou VE. Technicolour transgenics: imaging tools for functional genomics in the mouse. Nat Rev Genet. 2003 Aug; 4(8):613-25. PMID: 12897773.
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      127. Pautler RG, Fraser S. The year(s) of the contrast agent - micro-MRI in the new millennium. Curr Opin Immunol. 2003 Aug; 15(4):385-92. PMID: 12900268.
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      128. Dickinson ME, Simbuerger E, Zimmermann B, Waters CW, Fraser S. Multiphoton excitation spectra in biological samples. J Biomed Opt. 2003 Jul; 8(3):329-38. PMID: 12880336.
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      129. Moats RA, Velan-Mullan S, Jacobs R, Gonzalez-Gomez I, Dubowitz DJ, Taga T, Khankaldyyan V, Schultz L, Fraser S, Nelson MD, Laug WE. Micro-MRI at 11.7 T of a murine brain tumor model using delayed contrast enhancement. Mol Imaging. 2003 Jul; 2(3):150-8. PMID: 14649058.
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      130. McBride HJ, Fatke B, Fraser S. Wnt signaling components in the chicken intestinal tract. Dev Biol. 2003 Apr 01; 256(1):18-33. PMID: 12654289.
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      131. Chen H, Detmer SA, Ewald AJ, Griffin EE, Fraser S, Chan DC. Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. J Cell Biol. 2003 Jan 20; 160(2):189-200. PMID: 12527753; PMCID: PMC2172648.
      132. Hove JR, Köster RW, Forouhar AS, Acevedo-Bolton G, Fraser S, Gharib M. Intracardiac fluid forces are an essential epigenetic factor for embryonic cardiogenesis. Nature. 2003 Jan 09; 421(6919):172-7. PMID: 12520305.
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      133. Kulesa PM, Fraser S. Cell dynamics during somite boundary formation revealed by time-lapse analysis. Science. 2002 Nov 01; 298(5595):991-5. PMID: 12411697.
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      134. Ewald AJ, McBride H, Reddington M, Fraser S, Kerschmann R. Surface imaging microscopy, an automated method for visualizing whole embryo samples in three dimensions at high resolution. Dev Dyn. 2002 Nov; 225(3):369-75. PMID: 12412023.
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      135. Ruffins SW, Jacobs RE, Fraser S. Towards a Tralfamadorian view of the embryo: multidimensional imaging of development. Curr Opin Neurobiol. 2002 Oct; 12(5):580-6. PMID: 12367639.
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      136. Modo M, Cash D, Mellodew K, Williams SC, Fraser S, Meade TJ, Price J, Hodges H. Tracking transplanted stem cell migration using bifunctional, contrast agent-enhanced, magnetic resonance imaging. Neuroimage. 2002 Oct; 17(2):803-11. PMID: 12377155.
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      137. Dmochowski IJ, Dmochowski JE, Oliveri P, Davidson EH, Fraser S. Quantitative imaging of cis-regulatory reporters in living embryos. Proc Natl Acad Sci U S A. 2002 Oct 01; 99(20):12895-900. PMID: 12237411; PMCID: PMC130556.
      138. Kastner J, Solomon J, Fraser S. Modeling a hox gene network in silico using a stochastic simulation algorithm. Dev Biol. 2002 Jun 01; 246(1):122-31. PMID: 12027438.
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      139. Lehmann OJ, Ebenezer ND, Ekong R, Ocaka L, Mungall AJ, Fraser S, McGill JI, Hitchings RA, Khaw PT, Sowden JC, Povey S, Walter MA, Bhattacharya SS, Jordan T. Ocular developmental abnormalities and glaucoma associated with interstitial 6p25 duplications and deletions. Invest Ophthalmol Vis Sci. 2002 Jun; 43(6):1843-9. PMID: 12036988.
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      140. Wallingford JB, Fraser S, Harland RM. Convergent extension: the molecular control of polarized cell movement during embryonic development. Dev Cell. 2002 Jun; 2(6):695-706. PMID: 12062082.
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