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    Sarah Hamm-Alvarez, PhD

    TitleProfessor of Ophthalmology and Pharmacology and Pharmaceutical Sciences
    SchoolKeck School of Medicine of USC
    DepartmentOphthalmology
    AddressMCA 346A 1333 San Pablo Street
    Health Sciences Campus
    Los Angeles California 90033-9224
    Phone+1 323 442 1445
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      Other Positions
      TitleAssociate Dean For Basic and Translational Research


      Collapse Overview 
      Collapse Overview
      Sarah Hamm-Alvarez, PhD, is Professor of Ophthalmology and Vice Chair for Basic Research at the USC Roski Institute, and Associate Dean, Basic and Translational Sciences, USC Keck School of Medicine. Dr. Hamm-Alvarez holds a secondary faculty appointment as Professor of Pharmacology and Pharmaceutical Sciences at USC's School of Pharmacy. She also directs the Office of Research Development at the Southern California Clinical and Translational Science Institute (SC-CTSI).

      An expert in cellular membrane trafficking and high-resolution imaging, Professor Hamm-Alvarez is recognized internationally for her work on regulated exocytosis in acinar cells. Her membrane-trafficking research has sparked new growth of translational programs in her laboratory ultimately aimed at improving clinical diagnosis and treatment of SjÖgren’s syndrome, an autoimmune disease affecting the secretory function of the lacrimal gland and the integrity of the ocular surface. Other of her research programs focus on protein-targeted drug delivery. characterizing nanoparticle interactions with cells, and development of protein polymer-based drug delivery systems for ocular diseases.

      Professor Hamm-Alvarez was awarded a PhD in Biochemistry from Duke University in 1990, where she also completed a postdoctoral fellowship in Cell Biology in 1993. She has authored numerous papers, served on editorial boards and grant review committees, is an AAPS fellow, and received an Honorary Doctorate from Linneaus University in Sweden.


      Collapse Biography 
      Collapse Education and Training
      Carleton College, Northfield, MNBA1986Chemistry
      Duke University, Durham, NCPh. D.1990Biochemistry
      Duke University, Durham, NCpostdoctoral1993Cell Biology

      Collapse Research 
      Collapse Research Activities and Funding
      Protein-polymer nanomedicines for Sjogren's syndrome
      National Institutes of Health/National Eye Institute RO1EY026635-0A1Mar 1, 2017 - Feb 28, 2021
      Role: One of two multi-PI investigators with JA MacKay
      Identification of tear biomarkers for Parkinson's disease patients
      Michael J Fox Foundation Jan 1, 2017 - Dec 31, 2018
      Role: Principal Investigator
      Microtubule-Based Transport in Lacrimal Gland Function
      NIH R01EY011386Jul 1, 1996 - Jun 30, 2021
      Role: Principal Investigator

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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Meng Z, Klinngam W, Edman MC, Hamm-Alvarez S. Interferon-? treatment in vitro elicits some of the changes in cathepsin S and antigen presentation characteristic of lacrimal glands and corneas from the NOD mouse model of Sjögren's Syndrome. PLoS One. 2017; 12(9):e0184781. PMID: 28902875.
        View in: PubMed
      2. Aluri HS, Samizadeh M, Edman MC, Hawley DR, Armaos HL, Janga SR, Meng Z, Sendra VG, Hamrah P, Kublin CL, Hamm-Alvarez S, Zoukhri D. Delivery of Bone Marrow-Derived Mesenchymal Stem Cells Improves Tear Production in a Mouse Model of Sjögren's Syndrome. Stem Cells Int. 2017; 2017:3134543. PMID: 28348600.
        View in: PubMed
      3. Shah M, Edman MC, Reddy Janga S, Yarber F, Meng Z, Klinngam W, Bushman J, Ma T, Liu S, Louie S, Mehta A, Ding C, MacKay JA, Hamm-Alvarez S. Rapamycin Eye Drops Suppress Lacrimal Gland Inflammation In a Murine Model of Sjögren's Syndrome. Invest Ophthalmol Vis Sci. 2017 Jan 01; 58(1):372-385. PMID: 28122086.
        View in: PubMed
      4. Meng Z, Edman MC, Hsueh PY, Chen CY, Klinngam W, Tolmachova T, Okamoto CT, Hamm-Alvarez S. Imbalanced Rab3D versus Rab27 increases cathepsin S secretion from lacrimal acini in a mouse model of Sjögren's Syndrome. Am J Physiol Cell Physiol. 2016 Jun 01; 310(11):C942-54. PMID: 27076615; PMCID: PMC4935202 [Available on 06/01/17].
      5. Zhou Y, Meng Z, Edman-Woolcott M, Hamm-Alvarez S, Zandi E. Multidimensional Separation Using HILIC and SCX Pre-fractionation for RP LC-MS/MS Platform with Automated Exclusion List-based MS Data Acquisition with Increased Protein Quantification. J Proteomics Bioinform. 2015 Nov; 8(11):260-265. PMID: 26807013.
        View in: PubMed
      6. Despanie J, Dhandhukia JP, Hamm-Alvarez S, MacKay JA. Elastin-like polypeptides: Therapeutic applications for an emerging class of nanomedicines. J Control Release. 2016 Oct 28; 240:93-108. PMID: 26578439.
        View in: PubMed
      7. Hsueh PY, Edman MC, Sun G, Shi P, Xu S, Lin YA, Cui H, Hamm-Alvarez S, MacKay JA. Tear-mediated delivery of nanoparticles through transcytosis of the lacrimal gland. J Control Release. 2015 Jun 28; 208:2-13. PMID: 25523518; PMCID: PMC4456098.
      8. Wang W, Despanie J, Shi P, Edman-Woolcott MC, Lin YA, Cui H, Heur JM, Fini ME, Hamm-Alvarez S, MacKay JA. Lacritin-mediated regeneration of the corneal epithelia by protein polymer nanoparticles. J Mater Chem B Mater Biol Med. 2014 Dec 14; 2(46):8131-8141. PMID: 25530855.
        View in: PubMed
      9. Wang W, Jashnani A, Aluri SR, Gustafson JA, Hsueh PY, Yarber F, McKown RL, Laurie GW, Hamm-Alvarez S, MacKay JA. A thermo-responsive protein treatment for dry eyes. J Control Release. 2015 Feb 10; 199:156-67. PMID: 25481446; PMCID: PMC4456095.
      10. Pastuszka MK, Okamoto CT, Hamm-Alvarez S, MacKay JA. Flipping the Switch on Clathrin-Mediated Endocytosis using Thermally Responsive Protein Microdomains. Adv Funct Mater. 2014 Sep 10; 24(34):5340-5347. PMID: 25419208.
        View in: PubMed
      11. Hamm-Alvarez S, Janga SR, Edman MC, Madrigal S, Shah M, Frousiakis SE, Renduchintala K, Zhu J, Bricel S, Silka K, Bach D, Heur M, Christianakis S, Arkfeld DG, Irvine J, Mack WJ, Stohl W. Tear cathepsin S as a candidate biomarker for Sjögren's syndrome. Arthritis Rheumatol. 2014 Jul; 66(7):1872-81. PMID: 24644101; PMCID: PMC4077975.
      12. Shah M, Edman MC, Janga SR, Shi P, Dhandhukia J, Liu S, Louie SG, Rodgers K, Mackay JA, Hamm-Alvarez S. A rapamycin-binding protein polymer nanoparticle shows potent therapeutic activity in suppressing autoimmune dacryoadenitis in a mouse model of Sjögren's syndrome. J Control Release. 2013 Nov 10; 171(3):269-79. PMID: 23892265; PMCID: PMC3796004.
      13. Xu S, Ma L, Evans E, Okamoto CT, Hamm-Alvarez S. Polymeric immunoglobulin receptor traffics through two distinct apically targeted pathways in primary lacrimal gland acinar cells. J Cell Sci. 2013 Jun 15; 126(Pt 12):2704-17. PMID: 23606742; PMCID: PMC3687702.
      14. Fazlollahi F, Kim YH, Sipos A, Hamm-Alvarez S, Borok Z, Kim KJ, Crandall ED. Nanoparticle translocation across mouse alveolar epithelial cell monolayers: species-specific mechanisms. Nanomedicine. 2013 Aug; 9(6):786-94. PMID: 23454523; PMCID: PMC3702651.
      15. Gonzalez JM, Hamm-Alvarez S, Tan JC. Analyzing live cellularity in the human trabecular meshwork. Invest Ophthalmol Vis Sci. 2013 Feb 05; 54(2):1039-47. PMID: 23249706; PMCID: PMC3565993.
      16. Pastuszka MK, Janib SM, Weitzhandler I, Okamoto CT, Hamm-Alvarez S, Mackay JA. A tunable and reversible platform for the intracellular formation of genetically engineered protein microdomains. Biomacromolecules. 2012 Nov 12; 13(11):3439-44. PMID: 23088632; PMCID: PMC3500625.
      17. Xu S, Olenyuk BZ, Okamoto CT, Hamm-Alvarez S. Targeting receptor-mediated endocytotic pathways with nanoparticles: rationale and advances. Adv Drug Deliv Rev. 2013 Jan; 65(1):121-38. PMID: 23026636; PMCID: PMC3565049.
      18. Tan JC, Gonzalez JM, Hamm-Alvarez S, Song J. In situ autofluorescence visualization of human trabecular meshwork structure. Invest Ophthalmol Vis Sci. 2012 Apr 24; 53(4):2080-8. PMID: 22410566; PMCID: PMC3995572.
      19. Chiang L, Karvar S, Hamm-Alvarez S. Direct imaging of RAB27B-enriched secretory vesicle biogenesis in lacrimal acinar cells reveals origins on a nascent vesicle budding site. PLoS One. 2012; 7(2):e31789. PMID: 22363735; PMCID: PMC3282733.
      20. Lagor WR, Fields DW, Khetarpal SA, Kumaravel A, Lin W, Weintraub N, Wu K, Hamm-Alvarez S, Drazul-Schrader D, de la Llera-Moya M, Rothblat GH, Rader DJ. The effects of apolipoprotein F deficiency on high density lipoprotein cholesterol metabolism in mice. PLoS One. 2012; 7(2):e31616. PMID: 22363685; PMCID: PMC3282742.
      21. Contreras J, Hsueh PY, Pei H, Hamm-Alvarez S. Use of nucleofection to efficiently transfect primary rabbit lacrimal gland acinar cells. Cytotechnology. 2012 Mar; 64(2):149-56. PMID: 22138892; PMCID: PMC3279577.
      22. Fazlollahi F, Sipos A, Kim YH, Hamm-Alvarez S, Borok Z, Kim KJ, Crandall ED. Translocation of PEGylated quantum dots across rat alveolar epithelial cell monolayers. Int J Nanomedicine. 2011; 6:2849-57. PMID: 22131830; PMCID: PMC3224711.
      23. Xu S, Edman M, Kothawala MS, Sun G, Chiang L, Mircheff A, Zhu L, Okamoto C, Hamm-Alvarez S. A Rab11a-enriched subapical membrane compartment regulates a cytoskeleton-dependent transcytotic pathway in secretory epithelial cells of the lacrimal gland. J Cell Sci. 2011 Oct 15; 124(Pt 20):3503-14. PMID: 21984810; PMCID: PMC3196860.
      24. Contreras J, Elnagar AY, Hamm-Alvarez S, Camarero JA. Cellular uptake of cyclotide MCoTI-I follows multiple endocytic pathways. J Control Release. 2011 Oct 30; 155(2):134-43. PMID: 21906641; PMCID: PMC3195939.
      25. Sun G, Hsueh PY, Janib SM, Hamm-Alvarez S, MacKay JA. Design and cellular internalization of genetically engineered polypeptide nanoparticles displaying adenovirus knob domain. J Control Release. 2011 Oct 30; 155(2):218-26. PMID: 21699930; PMCID: PMC3196066.
      26. Chiang L, Ngo J, Schechter JE, Karvar S, Tolmachova T, Seabra MC, Hume AN, Hamm-Alvarez S. Rab27b regulates exocytosis of secretory vesicles in acinar epithelial cells from the lacrimal gland. Am J Physiol Cell Physiol. 2011 Aug; 301(2):C507-21. PMID: 21525430; PMCID: PMC3154548.
      27. Fazlollahi F, Angelow S, Yacobi NR, Marchelletta R, Yu AS, Hamm-Alvarez S, Borok Z, Kim KJ, Crandall ED. Polystyrene nanoparticle trafficking across MDCK-II. Nanomedicine. 2011 Oct; 7(5):588-94. PMID: 21310266; PMCID: PMC3130091.
      28. Kim YH, Fazlollahi F, Kennedy IM, Yacobi NR, Hamm-Alvarez S, Borok Z, Kim KJ, Crandall ED. Alveolar epithelial cell injury due to zinc oxide nanoparticle exposure. Am J Respir Crit Care Med. 2010 Dec 01; 182(11):1398-409. PMID: 20639441; PMCID: PMC3029930.
      29. Contreras J, Xie J, Chen YJ, Pei H, Zhang G, Fraser CL, Hamm-Alvarez S. Intracellular uptake and trafficking of difluoroboron dibenzoylmethane-polylactide nanoparticles in HeLa cells. ACS Nano. 2010 May 25; 4(5):2735-47. PMID: 20420413; PMCID: PMC2948672.
      30. Li X, Wu K, Edman M, Schenke-Layland K, MacVeigh-Aloni M, Janga SR, Schulz B, Hamm-Alvarez S. Increased expression of cathepsins and obesity-induced proinflammatory cytokines in lacrimal glands of male NOD mouse. Invest Ophthalmol Vis Sci. 2010 Oct; 51(10):5019-29. PMID: 20463324; PMCID: PMC3066616.
      31. Schenke-Layland K, Xie J, Magnusson M, Angelis E, Li X, Wu K, Reinhardt DP, Maclellan WR, Hamm-Alvarez S. Lymphocytic infiltration leads to degradation of lacrimal gland extracellular matrix structures in NOD mice exhibiting a Sjögren's syndrome-like exocrinopathy. Exp Eye Res. 2010 Feb; 90(2):223-37. PMID: 19852957; PMCID: PMC2821966.
      32. Hamm-Alvarez S, Cadenas E. Mitochondrial medicine and therapeutics, Part II. Preface. Adv Drug Deliv Rev. 2009 Nov 30; 61(14):1233. PMID: 19835920.
        View in: PubMed
      33. Yacobi NR, Malmstadt N, Fazlollahi F, DeMaio L, Marchelletta R, Hamm-Alvarez S, Borok Z, Kim KJ, Crandall ED. Mechanisms of alveolar epithelial translocation of a defined population of nanoparticles. Am J Respir Cell Mol Biol. 2010 May; 42(5):604-14. PMID: 19574531; PMCID: PMC2874446.
      34. Wu K, Joffre C, Li X, MacVeigh-Aloni M, Hom M, Hwang J, Ding C, Gregoire S, Bretillon L, Zhong JF, Hamm-Alvarez S. Altered expression of genes functioning in lipid homeostasis is associated with lipid deposition in NOD mouse lacrimal gland. Exp Eye Res. 2009 Sep; 89(3):319-32. PMID: 19345210; PMCID: PMC2720431.
      35. Xie J, Marchelletta RR, Thomas PB, Jacobs DT, Yarber FA, Cheney RE, Hamm-Alvarez S, Trousdale MD. Transduced viral IL-10 is exocytosed from lacrimal acinar secretory vesicles in a myosin-dependent manner in response to carbachol. Exp Eye Res. 2009 Mar; 88(3):467-78. PMID: 19056381; PMCID: PMC2656410.
      36. Joo KI, Lei Y, Lee CL, Lo J, Xie J, Hamm-Alvarez S, Wang P. Site-specific labeling of enveloped viruses with quantum dots for single virus tracking. ACS Nano. 2008 Aug; 2(8):1553-62. PMID: 19079775.
        View in: PubMed
      37. Hamm-Alvarez S, Cadenas E. Mitochondrial medicine and mitochondrion-based therapeutics. Adv Drug Deliv Rev. 2008 Oct-Nov; 60(13-14):1437-8. PMID: 18692102.
        View in: PubMed
      38. Brockbank KG, MacLellan WR, Xie J, Hamm-Alvarez S, Chen ZZ, Schenke-Layland K. Quantitative second harmonic generation imaging of cartilage damage. Cell Tissue Bank. 2008 Dec; 9(4):299-307. PMID: 18431689.
        View in: PubMed
      39. Marchelletta RR, Jacobs DT, Schechter JE, Cheney RE, Hamm-Alvarez S. The class V myosin motor, myosin 5c, localizes to mature secretory vesicles and facilitates exocytosis in lacrimal acini. Am J Physiol Cell Physiol. 2008 Jul; 295(1):C13-28. PMID: 18434623; PMCID: PMC2493552.
      40. Yacobi NR, Demaio L, Xie J, Hamm-Alvarez S, Borok Z, Kim KJ, Crandall ED. Polystyrene nanoparticle trafficking across alveolar epithelium. Nanomedicine. 2008 Jun; 4(2):139-45. PMID: 18375191.
        View in: PubMed
      41. Evans E, Zhang W, Jerdeva G, Chen CY, Chen X, Hamm-Alvarez S, Okamoto CT. Direct interaction between Rab3D and the polymeric immunoglobulin receptor and trafficking through regulated secretory vesicles in lacrimal gland acinar cells. Am J Physiol Cell Physiol. 2008 Mar; 294(3):C662-74. PMID: 18171724; PMCID: PMC4046641.
      42. Norouziyan F, Shen WC, Hamm-Alvarez S. Tyrphostin A8 stimulates a novel trafficking pathway of apically endocytosed transferrin through Rab11-enriched compartments in Caco-2 cells. Am J Physiol Cell Physiol. 2008 Jan; 294(1):C7-21. PMID: 17959726.
        View in: PubMed
      43. Wang Y, Chiu CT, Nakamura T, Walker AM, Petridou B, Trousdale MD, Hamm-Alvarez S, Mircheff AK, Schechter JE. Traffic of endogenous, transduced, and endocytosed prolactin in rabbit lacrimal acinar cells. Exp Eye Res. 2007 Dec; 85(6):749-61. PMID: 17904551; PMCID: PMC2190296.
      44. Schenke-Layland K, Xie J, Angelis E, Starcher B, Wu K, Riemann I, MacLellan WR, Hamm-Alvarez S. Increased degradation of extracellular matrix structures of lacrimal glands implicated in the pathogenesis of Sjögren's syndrome. Matrix Biol. 2008 Jan; 27(1):53-66. PMID: 17689946; PMCID: PMC2394184.
      45. Schenke-Layland K, Xie J, Heydarkhan-Hagvall S, Hamm-Alvarez S, Stock UA, Brockbank KG, MacLellan WR. Optimized preservation of extracellular matrix in cardiac tissues: implications for long-term graft durability. Ann Thorac Surg. 2007 May; 83(5):1641-50. PMID: 17462373.
        View in: PubMed
      46. Wang Y, Chiu CT, Nakamura T, Walker AM, Petridou B, Trousdale MD, Hamm-Alvarez S, Schechter JE, Mircheff AK. Elevated prolactin redirects secretory vesicle traffic in rabbit lacrimal acinar cells. Am J Physiol Endocrinol Metab. 2007 Apr; 292(4):E1122-34. PMID: 17164431.
        View in: PubMed
      47. Xie J, Chiang L, Contreras J, Wu K, Garner JA, Medina-Kauwe L, Hamm-Alvarez S. Novel fiber-dependent entry mechanism for adenovirus serotype 5 in lacrimal acini. J Virol. 2006 Dec; 80(23):11833-51. PMID: 16987972; PMCID: PMC1642591.
      48. Selvam S, Thomas PB, Hamm-Alvarez S, Schechter JE, Stevenson D, Mircheff AK, Trousdale MD. Current status of gene delivery and gene therapy in lacrimal gland using viral vectors. Adv Drug Deliv Rev. 2006 Nov 15; 58(11):1243-57. PMID: 17056149; PMCID: PMC1773022.
      49. Rentsendorj A, Xie J, MacVeigh M, Agadjanian H, Bass S, Kim DH, Rossi J, Hamm-Alvarez S, Medina-Kauwe LK. Typical and atypical trafficking pathways of Ad5 penton base recombinant protein: implications for gene transfer. Gene Ther. 2006 May; 13(10):821-36. PMID: 16482205.
        View in: PubMed
      50. Andersson SV, Hamm-Alvarez S, Gierow JP. Integrin adhesion in regulation of lacrimal gland acinar cell secretion. Exp Eye Res. 2006 Sep; 83(3):543-53. PMID: 16631165.
        View in: PubMed
      51. Wu K, Jerdeva GV, da Costa SR, Sou E, Schechter JE, Hamm-Alvarez S. Molecular mechanisms of lacrimal acinar secretory vesicle exocytosis. Exp Eye Res. 2006 Jul; 83(1):84-96. PMID: 16530759.
        View in: PubMed
      52. Ding C, MacVeigh M, Pidgeon M, da Costa SR, Wu K, Hamm-Alvarez S, Schechter JE. Unique ultrastructure of exorbital lacrimal glands in male NOD and BALB/c mice. Curr Eye Res. 2006 Jan; 31(1):13-22. PMID: 16421015.
        View in: PubMed
      53. Medina-Kauwe LK, Xie J, Hamm-Alvarez S. Intracellular trafficking of nonviral vectors. Gene Ther. 2005 Dec; 12(24):1734-51. PMID: 16079885.
        View in: PubMed
      54. Jerdeva GV, Wu K, Yarber FA, Rhodes CJ, Kalman D, Schechter JE, Hamm-Alvarez S. Actin and non-muscle myosin II facilitate apical exocytosis of tear proteins in rabbit lacrimal acinar epithelial cells. J Cell Sci. 2005 Oct 15; 118(Pt 20):4797-812. PMID: 16219687; PMCID: PMC1482462.
      55. Mircheff AK, Wang Y, Jean Mde S, Ding C, Trousdale MD, Hamm-Alvarez S, Schechter JE. Mucosal immunity and self-tolerance in the ocular surface system. Ocul Surf. 2005 Oct; 3(4):182-92. PMID: 17131026.
        View in: PubMed
      56. da Costa SR, Wu K, Veigh MM, Pidgeon M, Ding C, Schechter JE, Hamm-Alvarez S. Male NOD mouse external lacrimal glands exhibit profound changes in the exocytotic pathway early in postnatal development. Exp Eye Res. 2006 Jan; 82(1):33-45. PMID: 16005870; PMCID: PMC1351294.
      57. Jerdeva GV, Yarber FA, Trousdale MD, Rhodes CJ, Okamoto CT, Dartt DA, Hamm-Alvarez S. Dominant-negative PKC-epsilon impairs apical actin remodeling in parallel with inhibition of carbachol-stimulated secretion in rabbit lacrimal acini. Am J Physiol Cell Physiol. 2005 Oct; 289(4):C1052-68. PMID: 15930141; PMCID: PMC1414898.
      58. Rentsendorj A, Agadjanian H, Chen X, Cirivello M, Macveigh M, Kedes L, Hamm-Alvarez S, Medina-Kauwe LK. The Ad5 fiber mediates nonviral gene transfer in the absence of the whole virus, utilizing a novel cell entry pathway. Gene Ther. 2005 Feb; 12(3):225-37. PMID: 15483666.
        View in: PubMed
      59. Rose CM, Qian L, Hakim L, Wang Y, Jerdeva GY, Marchelletta R, Nakamura T, Hamm-Alvarez S, Mircheff AK. Accumulation of catalytically active proteases in lacrimal gland acinar cell endosomes during chronic ex vivo muscarinic receptor stimulation. Scand J Immunol. 2005 Jan; 61(1):36-50. PMID: 15644121.
        View in: PubMed
      60. Chu C, Okamoto CT, Hamm-Alvarez S, Lee VH. Stable transfection of MDCK cells with epitope-tagged human PepT1. Pharm Res. 2004 Nov; 21(11):1970-3. PMID: 15587917.
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      61. Qian L, Xie J, Rose CM, Sou E, Zeng H, Hamm-Alvarez S, Mircheff AK. Altered traffic to the lysosome in an ex vivo lacrimal acinar cell model for chronic muscarinic receptor stimulation. Exp Eye Res. 2004 Nov; 79(5):665-75. PMID: 15500825.
        View in: PubMed
      62. Wang Y, Xie J, Yarber FA, Mazurek C, Trousdale MD, Medina-Kauwe LK, Kasahara N, Hamm-Alvarez S. Adenoviral capsid modulates secretory compartment organization and function in acinar epithelial cells from rabbit lacrimal gland. Gene Ther. 2004 Jun; 11(12):970-81. PMID: 15029229.
        View in: PubMed
      63. Xie J, Qian L, Wang Y, Hamm-Alvarez S, Mircheff AK. Role of the microtubule cytoskeleton in traffic of EGF through the lacrimal acinar cell endomembrane network. Exp Eye Res. 2004 Jun; 78(6):1093-106. PMID: 15109916.
        View in: PubMed
      64. Xie J, Qian L, Wang Y, Rose CM, Yang T, Nakamura T, Hamm-Alvarez S, Mircheff AK. Novel biphasic traffic of endocytosed EGF to recycling and degradative compartments in lacrimal gland acinar cells. J Cell Physiol. 2004 Apr; 199(1):108-25. PMID: 14978740.
        View in: PubMed
      65. Hamm-Alvarez S, Xie J, Wang Y, Medina-Kauwe LK. Modulation of secretory functions in epithelia by adenovirus capsid proteins. J Control Release. 2003 Dec 05; 93(2):129-40. PMID: 14636719.
        View in: PubMed
      66. da Costa SR, Okamoto CT, Hamm-Alvarez S. Actin microfilaments et al.--the many components, effectors and regulators of epithelial cell endocytosis. Adv Drug Deliv Rev. 2003 Nov 14; 55(11):1359-83. PMID: 14597136.
        View in: PubMed
      67. Qian L, Wang Y, Xie J, Rose CM, Yang T, Nakamura T, Sandberg M, Zeng H, Schechter JE, Chow RH, Hamm-Alvarez S, Mircheff AK. Biochemical changes contributing to functional quiescence in lacrimal gland acinar cells after chronic ex vivo exposure to a muscarinic agonist. Scand J Immunol. 2003 Nov; 58(5):550-65. PMID: 14629627.
        View in: PubMed
      68. Da Costa SR, Sou E, Xie J, Yarber FA, Okamoto CT, Pidgeon M, Kessels MM, Mircheff AK, Schechter JE, Qualmann B, Hamm-Alvarez S. Impairing actin filament or syndapin functions promotes accumulation of clathrin-coated vesicles at the apical plasma membrane of acinar epithelial cells. Mol Biol Cell. 2003 Nov; 14(11):4397-413. PMID: 12937279; PMCID: PMC266760.
      69. Wang Y, Jerdeva G, Yarber FA, da Costa SR, Xie J, Qian L, Rose CM, Mazurek C, Kasahara N, Mircheff AK, Hamm-Alvarez S. Cytoplasmic dynein participates in apically targeted stimulated secretory traffic in primary rabbit lacrimal acinar epithelial cells. J Cell Sci. 2003 May 15; 116(Pt 10):2051-65. PMID: 12679381.
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      70. Mircheff AK, Xie J, Qian L, Hamm-Alvarez S. Diverse perturbations may alter the lacrimal acinar cell autoantigenic spectra. DNA Cell Biol. 2002 May-Jun; 21(5-6):435-42. PMID: 12167246.
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      71. Yang L, Leong PK, Chen JO, Patel N, Hamm-Alvarez S, McDonough AA. Acute hypertension provokes internalization of proximal tubule NHE3 without inhibition of transport activity. Am J Physiol Renal Physiol. 2002 Apr; 282(4):F730-40. PMID: 11880335.
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      72. Hamm-Alvarez S. Focus on "EGF receptor downregulation depends on a trafficking motif in the distal tyrosine kinase domain". Am J Physiol Cell Physiol. 2002 Mar; 282(3):C417-9. PMID: 11832326.
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      73. da Costa SR, Andersson S, Arber F, Okamoto C, Hamm-Alvarez S. Cytoskeletal participation in stimulated secretion and compensatory apical plasma membrane retrieval in lacrimal gland acinar cells. Adv Exp Med Biol. 2002; 506(Pt A):199-205. PMID: 12613908.
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      74. Mircheff AK, Qian L, Xie J, Wang Y, Hamm-Alvarez S. M3 receptor autoimmunity: losing tolerance to a familiar protein. Adv Exp Med Biol. 2002; 506(Pt A):51-8. PMID: 12613888.
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      75. Qian L, Yang T, Chen H, Xie J, Zeng H, Warren DW, MacVeigh M, Meneray MA, Hamm-Alvarez S, Mircheff AK. Heterotrimeric GTP-binding proteins in the lacrimal acinar cell endomembrane system. Exp Eye Res. 2002 Jan; 74(1):7-22. PMID: 11878814.
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      76. Xie J, Qian L, Hamm-Alvarez S, Mircheff AK. Epidermal growth factor traffic in lacrimal acinar cells. Adv Exp Med Biol. 2002; 506(Pt A):213-7. PMID: 12613910.
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      77. Hamm-Alvarez S, Chang A, Wang Y, Jerdeva G, Lin HH, Kim KJ, Ann DK. Etk/Bmx activation modulates barrier function in epithelial cells. Am J Physiol Cell Physiol. 2001 Jun; 280(6):C1657-68. PMID: 11350762.
        View in: PubMed
      78. Lindberg J, Fernandez MA, Ropp JD, Hamm-Alvarez S. Nocodazole treatment of CV-1 cells enhances nuclear/perinuclear accumulation of lipid-DNA complexes and increases gene expression. Pharm Res. 2001 Feb; 18(2):246-9. PMID: 11405299.
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      79. da Costa SR, Wang Y, Vilalta PM, Schönthal AH, Hamm-Alvarez S. Changes in cytoskeletal organization in polyoma middle T antigen-transformed fibroblasts: involvement of protein phosphatase 2A and src tyrosine kinases. Cell Motil Cytoskeleton. 2000 Dec; 47(4):253-68. PMID: 11093247.
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      80. Wang Y, Duncan R, Ann DK, Hamm-Alvarez S. Identification of a novel taxol-sensitive kinase activity associated with the cytoskeleton. Biochem Biophys Res Commun. 2000 Nov 02; 277(3):525-30. PMID: 11061987.
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      81. Zhang L, da Costa SR, Yarber FA, Runnegar M, Hamm-Alvarez S. Protein phosphatase inhibitors alter cellular microtubules and reduce carbachol-dependent protein secretion in lacrimal acini. Curr Eye Res. 2000 May; 20(5):373-83. PMID: 10855032.
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      82. Lee VH, Chu C, Mahlin ED, Basu SK, Ann DK, Bolger MB, Haworth IS, Yeung AK, Wu SK, Hamm-Alvarez S, Okamoto CT. Biopharmaceutics of transmucosal peptide and protein drug administration: role of transport mechanisms with a focus on the involvement of PepT1. J Control Release. 1999 Nov 01; 62(1-2):129-40. PMID: 10518644.
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      83. Runnegar MT, Wei X, Hamm-Alvarez S. Increased protein phosphorylation of cytoplasmic dynein results in impaired motor function. Biochem J. 1999 Aug 15; 342 ( Pt 1):1-6. PMID: 10432292; PMCID: PMC1220428.
      84. Sonee M, Barrón E, Yarber FA, Hamm-Alvarez S. Taxol inhibits endosomal-lysosomal membrane trafficking at two distinct steps in CV-1 cells. Am J Physiol. 1998 Dec; 275(6 Pt 1):C1630-9. PMID: 9843725.
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      85. Bolger MB, Haworth IS, Yeung AK, Ann D, von Grafenstein H, Hamm-Alvarez S, Okamoto CT, Kim KJ, Basu SK, Wu S, Lee VH. Structure, function, and molecular modeling approaches to the study of the intestinal dipeptide transporter PepT1. J Pharm Sci. 1998 Nov; 87(11):1286-91. PMID: 9811478.
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      86. Hamm-Alvarez S, Sheetz MP. Microtubule-dependent vesicle transport: modulation of channel and transporter activity in liver and kidney. Physiol Rev. 1998 Oct; 78(4):1109-29. PMID: 9790571.
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      87. Yeung AK, Basu SK, Wu SK, Chu C, Okamoto CT, Hamm-Alvarez S, von Grafenstein H, Shen WC, Kim KJ, Bolger MB, Haworth IS, Ann DK, Lee VH. Molecular identification of a role for tyrosine 167 in the function of the human intestinal proton- coupled dipeptide transporter (hPepT1). Biochem Biophys Res Commun. 1998 Sep 08; 250(1):103-7. PMID: 9735340.
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      88. Vilalta PM, Zhang L, Hamm-Alvarez S. A novel taxol-induced vimentin phosphorylation and stabilization revealed by studies on stable microtubules and vimentin intermediate filaments. J Cell Sci. 1998 Jul; 111 ( Pt 13):1841-52. PMID: 9625747.
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      89. da Costa SR, Yarber FA, Zhang L, Sonee M, Hamm-Alvarez S. Microtubules facilitate the stimulated secretion of beta-hexosaminidase in lacrimal acinar cells. J Cell Sci. 1998 May; 111 ( Pt 9):1267-76. PMID: 9547304.
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      90. Hamm-Alvarez S, da Costa SR, Sonee M, Warren DW, Mircheff AK. Kinesin activation drives the retrieval of secretory membranes following secretion in rabbit lacrimal acinar cells. Adv Exp Med Biol. 1998; 438:177-80. PMID: 9634883.
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      91. Mircheff AK, Gierow JP, Yang T, Zhang J, Wood RL, Azzarolo AM, Warren DW, Zeng H, Guo Z, Kaslow HR, Hamm-Alvarez S, Okamoto CT, Bachmann M. Sjögren's autoimmunity: how perturbation of recognition in endomembrane traffic may provoke pathological recognition at the cell surface. J Mol Recognit. 1998; 11(1-6):40-8. PMID: 10076804.
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      92. Runnegar M, Wei X, Berndt N, Hamm-Alvarez S. Transferrin receptor recycling in rat hepatocytes is regulated by protein phosphatase 2A, possibly through effects on microtubule-dependent transport. Hepatology. 1997 Jul; 26(1):176-85. PMID: 9214467.
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      93. Hamm-Alvarez S, Da Costa S, Yang T, Wei X, Gierow JP, Mircheff AK. Cholinergic stimulation of lacrimal acinar cells promotes redistribution of membrane-associated kinesin and the secretory protein, beta-hexosaminidase, and increases kinesin motor activity. Exp Eye Res. 1997 Feb; 64(2):141-56. PMID: 9176047.
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      94. Sussman MA, Hamm-Alvarez S, Vilalta PM, Welch S, Kedes L. Involvement of phosphorylation in doxorubicin-mediated myofibril degeneration. An immunofluorescence microscopy analysis. Circ Res. 1997 Jan; 80(1):52-61. PMID: 8978322.
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      95. Hamm-Alvarez S, Sonee M, Loran-Goss K, Shen WC. Paclitaxel and nocodazole differentially alter endocytosis in cultured cells. Pharm Res. 1996 Nov; 13(11):1647-56. PMID: 8956329.
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      96. Hamm-Alvarez S, Wei X, Berndt N, Runnegar M. Protein phosphatases independently regulate vesicle movement and microtubule subpopulations in hepatocytes. Am J Physiol. 1996 Sep; 271(3 Pt 1):C929-43. PMID: 8843724.
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      97. Hamm-Alvarez S. Microtubule-based motor proteins: new targets for enhancing drug delivery? Pharm Res. 1996 Apr; 13(4):489-96. PMID: 8710737.
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      98. Hamm-Alvarez S, Alayof BE, Himmel HM, Kim PY, Crews AL, Strauss HC, Sheetz MP. Coordinate depression of bradykinin receptor recycling and microtubule-dependent transport by taxol. Proc Natl Acad Sci U S A. 1994 Aug 02; 91(16):7812-6. PMID: 7914372; PMCID: PMC44492.
      99. McIlvain JM, Burkhardt JK, Hamm-Alvarez S, Argon Y, Sheetz MP. Regulation of kinesin activity by phosphorylation of kinesin-associated proteins. J Biol Chem. 1994 Jul 22; 269(29):19176-82. PMID: 8034676.
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      100. Hamm-Alvarez S, Kim PY, Sheetz MP. Regulation of vesicle transport in CV-1 cells and extracts. J Cell Sci. 1993 Nov; 106 ( Pt 3):955-66. PMID: 7905879.
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      101. Hamm-Alvarez S, Sancar A, Rajagopalan KV. The folate cofactor of Escherichia coli DNA photolyase acts catalytically. J Biol Chem. 1990 Oct 25; 265(30):18656-62. PMID: 2211728.
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      102. Hamm-Alvarez S, Sancar A, Rajagopalan KV. The presence and distribution of reduced folates in Escherichia coli dihydrofolate reductase mutants. J Biol Chem. 1990 Jun 15; 265(17):9850-6. PMID: 2190985.
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      103. Hamm-Alvarez S, Sancar A, Rajagopalan KV. Role of enzyme-bound 5,10-methenyltetrahydropteroylpolyglutamate in catalysis by Escherichia coli DNA photolyase. J Biol Chem. 1989 Jun 05; 264(16):9649-56. PMID: 2656701.
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      104. Johnson JL, Hamm-Alvarez S, Payne G, Sancar GB, Rajagopalan KV, Sancar A. Identification of the second chromophore of Escherichia coli and yeast DNA photolyases as 5,10-methenyltetrahydrofolate. Proc Natl Acad Sci U S A. 1988 Apr; 85(7):2046-50. PMID: 2895469; PMCID: PMC279925.