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    Sarah Hamm-Alvarez, PhD

    TitleProfessor of Ophthalmology and Pharmacology and Pharmaceutical Sciences
    SchoolKeck School of Medicine of USC
    DepartmentOphthalmology
    AddressMCA 346A 1333 San Pablo Street
    Health Sciences Campus
    Los Angeles California 90033-9224
    Phone+1 323 442 1445
      Other Positions
      TitleAssociate Dean For Basic and Translational Research


       Overview 
       Overview
      Sarah Hamm-Alvarez, PhD, is Professor of Ophthalmology and Vice Chair for Basic Research at the USC Roski Institute, and Associate Dean, Basic and Translational Sciences, USC Keck School of Medicine. Dr. Hamm-Alvarez holds a secondary faculty appointment as Professor of Pharmacology and Pharmaceutical Sciences at USC's School of Pharmacy. She also directs Research Development at the Southern California Clinical and Translational Science Institute (SC-CTSI).

      An expert in cellular membrane trafficking and high-resolution imaging, Professor Hamm-Alvarez is recognized internationally for her work on regulated exocytosis in acinar cells. Her membrane-trafficking research has sparked new growth of translational programs in her laboratory ultimately aimed at improving clinical diagnosis and treatment of SjÖgren’s syndrome, an autoimmune disease affecting the secretory function of the lacrimal gland and the integrity of the ocular surface. Other of her research programs focus on protein-targeted drug delivery. characterizing nanoparticle interactions with cells, and development of protein polymer-based drug delivery systems for ocular diseases.

      Professor Hamm-Alvarez was awarded a PhD in Biochemistry from Duke University in 1990, where she also completed a postdoctoral fellowship in Cell Biology in 1993. She has authored numerous papers, served on editorial boards and grant review committees, is an AAPS fellow, and received an Honorary Doctorate from Linneaus University in Sweden.


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       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Aluri HS, Samizadeh M, Edman MC, Hawley DR, Armaos HL, Janga SR, Meng Z, Sendra VG, Hamrah P, Kublin CL, Hamm-Alvarez SF, Zoukhri D. Delivery of Bone Marrow-Derived Mesenchymal Stem Cells Improves Tear Production in a Mouse Model of Sjögren's Syndrome. Stem Cells Int. 2017; 2017:3134543..
        View in: PubMed
      2. Shah M, Edman MC, Reddy Janga S, Yarber F, Meng Z, Klinngam W, Bushman J, Ma T, Liu S, Louie S, Mehta A, Ding C, MacKay JA, Hamm-Alvarez SF. Rapamycin Eye Drops Suppress Lacrimal Gland Inflammation In a Murine Model of Sjögren's Syndrome. Invest Ophthalmol Vis Sci. 2017 Jan 01; 58(1):372-385..
        View in: PubMed
      3. Meng Z, Edman MC, Hsueh PY, Chen CY, Klinngam W, Tolmachova T, Okamoto CT, Hamm-Alvarez SF. Imbalanced Rab3D versus Rab27 increases cathepsin S secretion from lacrimal acini in a mouse model of Sjögren's Syndrome. Am J Physiol Cell Physiol. 2016 Jun 1; 310(11):C942-54..
        View in: PubMed
      4. Zhou Y, Meng Z, Edman-Woolcott M, Hamm-Alvarez SF, Zandi E. Multidimensional Separation Using HILIC and SCX Pre-fractionation for RP LC-MS/MS Platform with Automated Exclusion List-based MS Data Acquisition with Increased Protein Quantification. J Proteomics Bioinform. 2015 Nov; 8(11):260-265..
        View in: PubMed
      5. Despanie J, Dhandhukia JP, Hamm-Alvarez SF, MacKay JA. Elastin-like polypeptides: Therapeutic applications for an emerging class of nanomedicines. J Control Release. 2016 Oct 28; 240:93-108..
        View in: PubMed
      6. Hsueh PY, Edman MC, Sun G, Shi P, Xu S, Lin YA, Cui H, Hamm-Alvarez SF, MacKay JA. Tear-mediated delivery of nanoparticles through transcytosis of the lacrimal gland. J Control Release. 2015 Jun 28; 208:2-13..
        View in: PubMed
      7. Wang W, Despanie J, Shi P, Edman-Woolcott MC, Lin YA, Cui H, Heur JM, Fini ME, Hamm-Alvarez SF, MacKay JA. Lacritin-mediated regeneration of the corneal epithelia by protein polymer nanoparticles. J Mater Chem B Mater Biol Med. 2014 Dec 14; 2(46):8131-8141..
        View in: PubMed
      8. Wang W, Jashnani A, Aluri SR, Gustafson JA, Hsueh PY, Yarber F, McKown RL, Laurie GW, Hamm-Alvarez SF, MacKay JA. A thermo-responsive protein treatment for dry eyes. J Control Release. 2015 Feb 10; 199:156-67..
        View in: PubMed
      9. Pastuszka MK, Okamoto CT, Hamm-Alvarez SF, MacKay JA. Flipping the Switch on Clathrin-Mediated Endocytosis using Thermally Responsive Protein Microdomains. Adv Funct Mater. 2014 Sep 10; 24(34):5340-5347..
        View in: PubMed
      10. Hamm-Alvarez SF, Janga SR, Edman MC, Madrigal S, Shah M, Frousiakis SE, Renduchintala K, Zhu J, Bricel S, Silka K, Bach D, Heur M, Christianakis S, Arkfeld DG, Irvine J, Mack WJ, Stohl W. Tear Cathepsin S as a Candidate Biomarker for Sjögren's Syndrome. Arthritis Rheumatol. 2014 Jul; 66(7):1872-81..
        View in: PubMed
      11. Shah M, Edman MC, Janga SR, Shi P, Dhandhukia J, Liu S, Louie SG, Rodgers K, Mackay JA, Hamm-Alvarez SF. A rapamycin-binding protein polymer nanoparticle shows potent therapeutic activity in suppressing autoimmune dacryoadenitis in a mouse model of Sjögren's syndrome. J Control Release. 2013 Nov 10; 171(3):269-79..
        View in: PubMed
      12. Xu S, Ma L, Evans E, Okamoto CT, Hamm-Alvarez SF. Polymeric immunoglobulin receptor traffics through two distinct apically targeted pathways in primary lacrimal gland acinar cells. J Cell Sci. 2013 Jun 15; 126(Pt 12):2704-17..
        View in: PubMed
      13. Fazlollahi F, Kim YH, Sipos A, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED. Nanoparticle translocation across mouse alveolar epithelial cell monolayers: species-specific mechanisms. Nanomedicine. 2013 Aug; 9(6):786-94..
        View in: PubMed
      14. Gonzalez JM, Hamm-Alvarez S, Tan JC. Analyzing live cellularity in the human trabecular meshwork. Invest Ophthalmol Vis Sci. 2013 Feb; 54(2):1039-47..
        View in: PubMed
      15. Pastuszka MK, Janib SM, Weitzhandler I, Okamoto CT, Hamm-Alvarez S, Mackay JA. A tunable and reversible platform for the intracellular formation of genetically engineered protein microdomains. Biomacromolecules. 2012 Nov 12; 13(11):3439-44..
        View in: PubMed
      16. Xu S, Olenyuk BZ, Okamoto CT, Hamm-Alvarez SF. Targeting receptor-mediated endocytotic pathways with nanoparticles: Rationale and advances. Adv Drug Deliv Rev. 2012 Sep 29..
        View in: PubMed
      17. Tan JC, Gonzalez JM, Hamm-Alvarez S, Song J. In situ autofluorescence visualization of human trabecular meshwork structure. Invest Ophthalmol Vis Sci. 2012; 53(4):2080-8..
        View in: PubMed
      18. Chiang L, Karvar S, Hamm-Alvarez SF. Direct Imaging of RAB27B-Enriched Secretory Vesicle Biogenesis in Lacrimal Acinar Cells Reveals Origins on a Nascent Vesicle Budding Site. PLoS One. 2012; 7(2):e31789..
        View in: PubMed
      19. Lagor WR, Fields DW, Khetarpal SA, Kumaravel A, Lin W, Weintraub N, Wu K, Hamm-Alvarez SF, Drazul-Schrader D, de la Llera-Moya M, Rothblat GH, Rader DJ. The effects of apolipoprotein f deficiency on high density lipoprotein cholesterol metabolism in mice. PLoS One. 2012; 7(2):e31616..
        View in: PubMed
      20. Contreras J, Hsueh PY, Pei H, Hamm-Alvarez SF. Use of nucleofection to efficiently transfect primary rabbit lacrimal gland acinar cells. Cytotechnology. 2012 Mar; 64(2):149-56..
        View in: PubMed
      21. Fazlollahi F, Sipos A, Kim YH, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED. Translocation of PEGylated quantum dots across rat alveolar epithelial cell monolayers. Int J Nanomedicine. 2011; 6:2849-57..
        View in: PubMed
      22. Xu S, Edman M, Kothawala MS, Sun G, Chiang L, Mircheff A, Zhu L, Okamoto C, Hamm-Alvarez S. A Rab11a-enriched subapical membrane compartment regulates a cytoskeleton-dependent transcytotic pathway in secretory epithelial cells of the lacrimal gland. J Cell Sci. 2011 Oct 15; 124(Pt 20):3503-14..
        View in: PubMed
      23. Contreras J, Elnagar AY, Hamm-Alvarez SF, Camarero JA. Cellular uptake of cyclotide MCoTI-I follows multiple endocytic pathways. J Control Release. 2011 Oct 30; 155(2):134-43..
        View in: PubMed
      24. Sun G, Hsueh PY, Janib SM, Hamm-Alvarez S, Andrew MacKay J. Design and cellular internalization of genetically engineered polypeptide nanoparticles displaying adenovirus knob domain. J Control Release. 2011 Oct 30; 155(2):218-26..
        View in: PubMed
      25. Chiang L, Ngo J, Schechter JE, Karvar S, Tolmachova T, Seabra MC, Hume AN, Hamm-Alvarez SF. Rab27b regulates exocytosis of secretory vesicles in acinar epithelial cells from the lacrimal gland. Am J Physiol Cell Physiol. 2011 Aug; 301(2):C507-21..
        View in: PubMed
      26. Fazlollahi F, Angelow S, Yacobi NR, Marchelletta R, Yu AS, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED. Polystyrene nanoparticle trafficking across MDCK-II. Nanomedicine. 2011 Oct; 7(5):588-94..
        View in: PubMed
      27. Kim YH, Fazlollahi F, Kennedy IM, Yacobi NR, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED. Alveolar epithelial cell injury due to zinc oxide nanoparticle exposure. Am J Respir Crit Care Med. 2010 Dec 1; 182(11):1398-409..
        View in: PubMed
      28. Contreras J, Xie J, Chen YJ, Pei H, Zhang G, Fraser CL, Hamm-Alvarez SF. Intracellular uptake and trafficking of difluoroboron dibenzoylmethane-polylactide nanoparticles in HeLa cells. ACS Nano. 2010 May 25; 4(5):2735-47..
        View in: PubMed
      29. Li X, Wu K, Edman M, Schenke-Layland K, MacVeigh-Aloni M, Janga SR, Schulz B, Hamm-Alvarez SF. Increased expression of cathepsins and obesity-induced proinflammatory cytokines in lacrimal glands of male NOD mouse. Invest Ophthalmol Vis Sci. 2010 Oct; 51(10):5019-29..
        View in: PubMed
      30. Schenke-Layland K, Xie J, Magnusson M, Angelis E, Li X, Wu K, Reinhardt DP, Maclellan WR, Hamm-Alvarez SF. Lymphocytic infiltration leads to degradation of lacrimal gland extracellular matrix structures in NOD mice exhibiting a Sjögren's syndrome-like exocrinopathy. Exp Eye Res. 2010 Feb; 90(2):223-37..
        View in: PubMed
      31. Hamm-Alvarez S, Cadenas E. Mitochondrial medicine and therapeutics, Part II. Preface. Adv Drug Deliv Rev. 2009 Nov 30; 61(14):1233..
        View in: PubMed
      32. Yacobi NR, Malmstadt N, Fazlollahi F, DeMaio L, Marchelletta R, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED. Mechanisms of alveolar epithelial translocation of a defined population of nanoparticles. Am J Respir Cell Mol Biol. 2010 May; 42(5):604-14..
        View in: PubMed
      33. Wu K, Joffre C, Li X, MacVeigh-Aloni M, Hom M, Hwang J, Ding C, Gregoire S, Bretillon L, Zhong JF, Hamm-Alvarez SF. Altered expression of genes functioning in lipid homeostasis is associated with lipid deposition in NOD mouse lacrimal gland. Exp Eye Res. 2009 Sep; 89(3):319-32..
        View in: PubMed
      34. Xie J, Marchelletta RR, Thomas PB, Jacobs DT, Yarber FA, Cheney RE, Hamm-Alvarez SF, Trousdale MD. Transduced viral IL-10 is exocytosed from lacrimal acinar secretory vesicles in a myosin-dependent manner in response to carbachol. Exp Eye Res. 2009 Mar; 88(3):467-78..
        View in: PubMed
      35. Joo KI, Lei Y, Lee CL, Lo J, Xie J, Hamm-Alvarez SF, Wang P. Site-specific labeling of enveloped viruses with quantum dots for single virus tracking. ACS Nano. 2008 Aug; 2(8):1553-62..
        View in: PubMed
      36. Hamm-Alvarez S, Cadenas E. Mitochondrial medicine and mitochondrion-based therapeutics. Adv Drug Deliv Rev. 2008 Oct-Nov; 60(13-14):1437-8..
        View in: PubMed
      37. Brockbank KG, MacLellan WR, Xie J, Hamm-Alvarez SF, Chen ZZ, Schenke-Layland K. Quantitative second harmonic generation imaging of cartilage damage. Cell Tissue Bank. 2008 Dec; 9(4):299-307..
        View in: PubMed
      38. Marchelletta RR, Jacobs DT, Schechter JE, Cheney RE, Hamm-Alvarez SF. The class V myosin motor, myosin 5c, localizes to mature secretory vesicles and facilitates exocytosis in lacrimal acini. Am J Physiol Cell Physiol. 2008 Jul; 295(1):C13-28..
        View in: PubMed
      39. Yacobi NR, Demaio L, Xie J, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED. Polystyrene nanoparticle trafficking across alveolar epithelium. Nanomedicine. 2008 Jun; 4(2):139-45..
        View in: PubMed
      40. Evans E, Zhang W, Jerdeva G, Chen CY, Chen X, Hamm-Alvarez SF, Okamoto CT. Direct interaction between Rab3D and the polymeric immunoglobulin receptor and trafficking through regulated secretory vesicles in lacrimal gland acinar cells. Am J Physiol Cell Physiol. 2008 Mar; 294(3):C662-74..
        View in: PubMed
      41. Norouziyan F, Shen WC, Hamm-Alvarez SF. Tyrphostin A8 stimulates a novel trafficking pathway of apically endocytosed transferrin through Rab11-enriched compartments in Caco-2 cells. Am J Physiol Cell Physiol. 2008 Jan; 294(1):C7-21..
        View in: PubMed
      42. Wang Y, Chiu CT, Nakamura T, Walker AM, Petridou B, Trousdale MD, Hamm-Alvarez SF, Mircheff AK, Schechter JE. Traffic of endogenous, transduced, and endocytosed prolactin in rabbit lacrimal acinar cells. Exp Eye Res. 2007 Dec; 85(6):749-61..
        View in: PubMed
      43. Schenke-Layland K, Xie J, Angelis E, Starcher B, Wu K, Riemann I, MacLellan WR, Hamm-Alvarez SF. Increased degradation of extracellular matrix structures of lacrimal glands implicated in the pathogenesis of Sjögren's syndrome. Matrix Biol. 2008 Jan; 27(1):53-66..
        View in: PubMed
      44. Schenke-Layland K, Xie J, Heydarkhan-Hagvall S, Hamm-Alvarez SF, Stock UA, Brockbank KG, MacLellan WR. Optimized preservation of extracellular matrix in cardiac tissues: implications for long-term graft durability. Ann Thorac Surg. 2007 May; 83(5):1641-50..
        View in: PubMed
      45. Wang Y, Chiu CT, Nakamura T, Walker AM, Petridou B, Trousdale MD, Hamm-Alvarez SF, Schechter JE, Mircheff AK. Elevated prolactin redirects secretory vesicle traffic in rabbit lacrimal acinar cells. Am J Physiol Endocrinol Metab. 2007 Apr; 292(4):E1122-34..
        View in: PubMed
      46. Xie J, Chiang L, Contreras J, Wu K, Garner JA, Medina-Kauwe L, Hamm-Alvarez SF. Novel fiber-dependent entry mechanism for adenovirus serotype 5 in lacrimal acini. J Virol. 2006 Dec; 80(23):11833-51..
        View in: PubMed
      47. Selvam S, Thomas PB, Hamm-Alvarez SF, Schechter JE, Stevenson D, Mircheff AK, Trousdale MD. Current status of gene delivery and gene therapy in lacrimal gland using viral vectors. Adv Drug Deliv Rev. 2006 Nov 15; 58(11):1243-57..
        View in: PubMed
      48. Andersson SV, Hamm-Alvarez SF, Gierow JP. Integrin adhesion in regulation of lacrimal gland acinar cell secretion. Exp Eye Res. 2006 Sep; 83(3):543-53..
        View in: PubMed
      49. Wu K, Jerdeva GV, da Costa SR, Sou E, Schechter JE, Hamm-Alvarez SF. Molecular mechanisms of lacrimal acinar secretory vesicle exocytosis. Exp Eye Res. 2006 Jul; 83(1):84-96..
        View in: PubMed
      50. Ding C, MacVeigh M, Pidgeon M, da Costa SR, Wu K, Hamm-Alvarez SF, Schechter JE. Unique ultrastructure of exorbital lacrimal glands in male NOD and BALB/c mice. Curr Eye Res. 2006 Jan; 31(1):13-22..
        View in: PubMed
      51. Jerdeva GV, Wu K, Yarber FA, Rhodes CJ, Kalman D, Schechter JE, Hamm-Alvarez SF. Actin and non-muscle myosin II facilitate apical exocytosis of tear proteins in rabbit lacrimal acinar epithelial cells. J Cell Sci. 2005 Oct 15; 118(Pt 20):4797-812..
        View in: PubMed
      52. Mircheff AK, Wang Y, Jean Mde S, Ding C, Trousdale MD, Hamm-Alvarez SF, Schechter JE. Mucosal immunity and self-tolerance in the ocular surface system. Ocul Surf. 2005 Oct; 3(4):182-92..
        View in: PubMed
      53. da Costa SR, Wu K, Veigh MM, Pidgeon M, Ding C, Schechter JE, Hamm-Alvarez SF. Male NOD mouse external lacrimal glands exhibit profound changes in the exocytotic pathway early in postnatal development. Exp Eye Res. 2006 Jan; 82(1):33-45..
        View in: PubMed
      54. Jerdeva GV, Yarber FA, Trousdale MD, Rhodes CJ, Okamoto CT, Dartt DA, Hamm-Alvarez SF. Dominant-negative PKC-epsilon impairs apical actin remodeling in parallel with inhibition of carbachol-stimulated secretion in rabbit lacrimal acini. Am J Physiol Cell Physiol. 2005 Oct; 289(4):C1052-68..
        View in: PubMed
      55. Qian L, Xie J, Rose CM, Sou E, Zeng H, Hamm-Alvarez SF, Mircheff AK. Altered traffic to the lysosome in an ex vivo lacrimal acinar cell model for chronic muscarinic receptor stimulation. Exp Eye Res. 2004 Nov; 79(5):665-75..
        View in: PubMed
      56. Chu C, Okamoto CT, Hamm-Alvarez SF, Lee VH. Stable transfection of MDCK cells with epitope-tagged human PepT1. Pharm Res. 2004 Nov; 21(11):1970-3..
        View in: PubMed
      57. Xie J, Qian L, Wang Y, Hamm-Alvarez SF, Mircheff AK. Role of the microtubule cytoskeleton in traffic of EGF through the lacrimal acinar cell endomembrane network. Exp Eye Res. 2004 Jun; 78(6):1093-106..
        View in: PubMed
      58. Xie J, Qian L, Wang Y, Rose CM, Yang T, Nakamura T, Hamm-Alvarez SF, Mircheff AK. Novel biphasic traffic of endocytosed EGF to recycling and degradative compartments in lacrimal gland acinar cells. J Cell Physiol. 2004 Apr; 199(1):108-25..
        View in: PubMed
      59. Hamm-Alvarez SF, Xie J, Wang Y, Medina-Kauwe LK. Modulation of secretory functions in epithelia by adenovirus capsid proteins. J Control Release. 2003 Dec 5; 93(2):129-40..
        View in: PubMed
      60. da Costa SR, Okamoto CT, Hamm-Alvarez SF. Actin microfilaments et al.--the many components, effectors and regulators of epithelial cell endocytosis. Adv Drug Deliv Rev. 2003 Nov 14; 55(11):1359-83..
        View in: PubMed
      61. Da Costa SR, Sou E, Xie J, Yarber FA, Okamoto CT, Pidgeon M, Kessels MM, Mircheff AK, Schechter JE, Qualmann B, Hamm-Alvarez SF. Impairing actin filament or syndapin functions promotes accumulation of clathrin-coated vesicles at the apical plasma membrane of acinar epithelial cells. Mol Biol Cell. 2003 Nov; 14(11):4397-413..
        View in: PubMed
      62. Wang Y, Jerdeva G, Yarber FA, da Costa SR, Xie J, Qian L, Rose CM, Mazurek C, Kasahara N, Mircheff AK, Hamm-Alvarez SF. Cytoplasmic dynein participates in apically targeted stimulated secretory traffic in primary rabbit lacrimal acinar epithelial cells. J Cell Sci. 2003 May 15; 116(Pt 10):2051-65..
        View in: PubMed
      63. Mircheff AK, Xie J, Qian L, Hamm-Alvarez SF. Diverse perturbations may alter the lacrimal acinar cell autoantigenic spectra. DNA Cell Biol. 2002 May-Jun; 21(5-6):435-42..
        View in: PubMed
      64. Yang L, Leong PK, Chen JO, Patel N, Hamm-Alvarez SF, McDonough AA. Acute hypertension provokes internalization of proximal tubule NHE3 without inhibition of transport activity. Am J Physiol Renal Physiol. 2002 Apr; 282(4):F730-40..
        View in: PubMed
      65. Hamm-Alvarez SF. Focus on "EGF receptor downregulation depends on a trafficking motif in the distal tyrosine kinase domain". Am J Physiol Cell Physiol. 2002 Mar; 282(3):C417-9..
        View in: PubMed
      66. Qian L, Yang T, Chen H, Xie J, Zeng H, Warren DW, MacVeigh M, Meneray MA, Hamm-Alvarez SF, Mircheff AK. Heterotrimeric GTP-binding proteins in the lacrimal acinar cell endomembrane system. Exp Eye Res. 2002 Jan; 74(1):7-22..
        View in: PubMed
      67. Mircheff AK, Qian L, Xie J, Wang Y, Hamm-Alvarez SF. M3 receptor autoimmunity: losing tolerance to a familiar protein. Adv Exp Med Biol. 2002; 506(Pt A):51-8..
        View in: PubMed
      68. Xie J, Qian L, Hamm-Alvarez SF, Mircheff AK. Epidermal growth factor traffic in lacrimal acinar cells. Adv Exp Med Biol. 2002; 506(Pt A):213-7..
        View in: PubMed
      69. da Costa SR, Andersson S, Arber F, Okamoto C, Hamm-Alvarez S. Cytoskeletal participation in stimulated secretion and compensatory apical plasma membrane retrieval in lacrimal gland acinar cells. Adv Exp Med Biol. 2002; 506(Pt A):199-205..
        View in: PubMed
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